keyword
https://read.qxmd.com/read/38437817/is-primary-poorly-differentiated-sarcomatoid-malignancy-of-the-parotid-gland-sarcomatoid-undifferentiated-dedifferentiated-melanoma-report-of-three-unusual-cases-diagnosed-by-fine-needle-aspiration-combined-with-histological-immunohistochemical-and-molecular
#21
JOURNAL ARTICLE
Jerzy Klijanienko, Julien Masliah-Planchon, Olivier Choussy, Guillaume Rougier, Antoine Dubray Vautrin, Maria Lesnik, Nathalie Badois, Wahib Ghanem, Jan Klos, Christophe Le Tourneau, Gregoire Marret, Raymond Barnhill, Adel K El-Naggar
INTRODUCTION: Poorly differentiated primary sarcomatoid parotid malignancies are extremely rare. These tumors have not been consistently studied by morphology, immunohistochemistry or molecular techniques. CASE PRESENTATION: We report three unusual cases of parotid gland poorly-differentiated sarcomatoid malignancy investigated by fine needle aspiration and studied histologically, by immunohistochemistry and molecular investigations. Aspirates showed poorly specific polymorphous sarcomatoid malignancy in all cases...
March 4, 2024: Acta Cytologica
https://read.qxmd.com/read/38435447/pancreatic-adenocarcinoma-with-co-occurrence-of-kras-and-egfr-mutations-case-report-and-literature-review
#22
Juhi Mody, Mandana Kamgar
INTRODUCTION: Mutation in Kristin ras sarcoma virus (KRAS) oncogene is the main driver in pancreatic ductal adenocarcinoma (PDAC) and is present in nearly 90% of patients with PDAC. Epidermal growth factor receptor ( EGFR ) mutation is rare in PDAC and is mostly present in the absence of KRAS mutation. Co-occurrence of KRAS and EGFR mutations is extremely rare, and the value of EGFR inhibition in these cases is unknown. CASE PRESENTATION: Here, we present a case of metastatic PDAC with co-occurrence of KRAS G12V and EGFR L730R...
2024: Case Reports in Oncology
https://read.qxmd.com/read/38433619/liver-transplant-for-primary-biliary-tract-neuroendocrine-tumor-in-a-nine-year-old-girl
#23
Anjali Rai, Lauren Sproule, Tatianna Larman, Kiyoko Oshima, Daniel Rhee, Kenneth Ng, Elizabeth King, Douglas Mogul, Kathryn Lemberg
BACKGROUND: Neuroendocrine tumors (NETs) are rare epithelial neoplasms that arise most commonly from the gastrointestinal tract. In pediatrics, the most common site of origin is in the appendix, with the liver being the most common site of metastasis. Neuroendocrine tumors arising from the biliary tract are extremely rare. METHODS: We describe a case of a nine-year-old girl who presented with obstructive cholestasis and was found to have multiple liver masses identified on biopsy as well-differentiated neuroendocrine tumor with an unknown primary tumor site...
March 2024: Pediatric Transplantation
https://read.qxmd.com/read/38429268/otud4-promotes-the-progression-of-glioblastoma-by-deubiquitinating-cdk1-and-activating-mapk-signaling-pathway
#24
JOURNAL ARTICLE
Mingxin Ci, Gaichao Zhao, Chongyang Li, Ruochen Liu, Xiaosong Hu, Jun Pan, Yang Shen, Guanghui Zhang, Yongsen Li, Li Zhang, Ping Liang, Hongjuan Cui
Glioblastoma, IDH-Wild type (GBM, CNS WHO Grade 4) is a highly heterogeneous and aggressive primary malignant brain tumor with high morbidity, high mortality, and poor patient prognosis. The global burden of GBM is increasing notably due to limited treatment options, drug delivery problems, and the lack of characteristic molecular targets. OTU deubiquitinase 4 (OTUD4) is a potential predictive factor for several cancers such as breast cancer, liver cancer, and lung cancer. However, its function in GBM remains unknown...
March 1, 2024: Cell Death & Disease
https://read.qxmd.com/read/38425780/a-case-of-pelvic-squamous-cell-carcinoma-of-unknown-primary-origin-that-responded-well-to-radiotherapy-and-nivolumab
#25
Hiroaki Koge, Ayako Hino, Akira Kakiuchi, Yayoi Yamamoto, Akira Kanbe, Daichi Kojima, Ayumi Horikawa, Tsunehiro Doiuchi, Hiroaki Kurihara
Squamous cell carcinoma of unknown primary origin in the pelvis is rare. We report a case of a 64-year-old woman with a large osteolytic squamous cell carcinoma of unknown primary origin in the pelvis that presented with p16 expression. The patient presented with leg pain and swelling and was admitted to our hospital. Computed tomography scans of the pelvis revealed a large osteolytic tumor. A computed tomography-guided needle biopsy was performed, and pathological examination revealed neoplastic cells with metastatic squamous cell carcinoma presenting with p16 expression...
May 2024: Radiology Case Reports
https://read.qxmd.com/read/38424363/immune-microenvironment-heterogeneity-of-concurrent-adenocarcinoma-and-squamous-cell-carcinoma-in-multiple-primary-lung-cancers
#26
JOURNAL ARTICLE
Jiahao Zhang, Yiheng Huang, Yichao Han, Dong Dong, Yuqin Cao, Xiang Chen, Di Liu, Xueyan Cheng, Debin Sun, Hecheng Li, Yajie Zhang
The molecular profiles and tumor immune microenvironment (TIME) of multiple primary lung cancers (MPLCs) presenting as concurrent lung adenocarcinoma (ADC) and squamous cell carcinoma (SQCC) remain unknown. We aimed to clarify these factors. We performed whole-exome sequencing (WES), RNA sequencing (RNA-Seq), and multiplex immunohistochemistry (mIHC) for five patients with concurrent ADC and SQCC. We found the genetic mutations were similar between ADC and SQCC groups. RNA-Seq revealed that the gene expression and pathways enriched in ADC and SQCC groups were quite different...
February 29, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38417600/investigating-the-molecular-mechanism-of-qizhu-anticancer-prescription-in-inhibiting-hepatocellular-carcinoma-based-on-high-resolution-mass-spectrometry-and-network-pharmacology
#27
JOURNAL ARTICLE
Jialing Sun, Mengqing Ma, Xin Zhong, Jing Li, Jinyu Yi, Renjie Zhang, Xingning Liu, Lanfen Peng, Xinfeng Sun, Wenxing Feng, Rui Hu, Qi Huang, Minling Lv, Kongli Fan, Xiaozhou Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Of all primary liver cancer cases, hepatocellular carcinoma (HCC) accounts for about 85%. Most patients with HCC receive a diagnosis in the medium-to-late stages or with chronic liver disease, have lost the opportunity for radical treatment, such as surgical resection, and their 5-year survival rate is low. Qizhu Anticancer Prescription (QZACP) is an empirical formula composed of traditional Chinese herbs that can clinically relieve HCC symptoms, inhibit the progression of HCC, reduce recurrence rate, and prolong survival; however, its exact mode of action remains unknown...
February 26, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38416134/deep-learning-model-for-tumor-type-prediction-using-targeted-clinical-genomic-sequencing-data
#28
JOURNAL ARTICLE
Madison Darmofal, Shalabh Suman, Gurnit Atwal, Michael Toomey, Jie-Fu Chen, Jason C Chang, Efsevia Vakiani, Anna M Varghese, Anoop Balakrishnan Rema, Aijazuddin Syed, Nikolaus Schultz, Michael F Berger, Quaid Morris
Tumor type guides clinical treatment decisions in cancer, but histology-based diagnosis remains challenging. Genomic alterations are highly diagnostic of tumor type, and tumor type classifiers trained on genomic features have been explored, but the most accurate methods are not clinically feasible, relying on features derived from whole genome sequencing (WGS), or predicting across limited cancer types. We use genomic features from a dataset of 39,787 solid tumors sequenced using a clinical targeted cancer gene panel to develop Genome-Derived-Diagnosis Ensemble (GDD-ENS): a hyperparameter ensemble for classifying tumor type using deep neural networks...
February 27, 2024: Cancer Discovery
https://read.qxmd.com/read/38415558/head-and-neck-cancer-of-unknown-primary-a-multicenter-retrospective-cohort-study-in-northern-thailand-an-endemic-nasopharyngeal-cancer-area
#29
JOURNAL ARTICLE
Pichit Sittitrai, Donyarat Ruenmarkkaew, Imjai Chitapanarux, Pooriwat Muangwong, Kanchana Kangsadarnwiroon, Ratcharin Benjawongsatien, Chonticha Srivanitchapoom, Supawit Donchalermpak, Tussawan Asakij
OBJECTIVE: This study aimed to evaluate the characteristics and oncological outcomes of head and neck carcinoma of unknown primary (HNCUP) patients in an endemic nasopharyngeal cancer (NPC) area. METHODS: One hundred and forty-four HNCUP patients curatively treated between January 1995 and December 2022 from 5 centers were retrospectively recruited onto the study to analyze the clinicopathological characteristics and oncological outcomes and compare them with historical data...
February 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38413296/risk-factors-for-mortality-in-children-with-hemorrhagic-cystitis-after-hematopoietic-transplant
#30
JOURNAL ARTICLE
Daniel Salevitz, Lucia Mirea, Gwen M Grimsby
INTRODUCTION: Hemorrhagic cystitis (HC) is a devastating complication of bone marrow (BMT) and stem cell transplant (SCT). Much of the literature has focused on exclusively adult patient populations, with limited evidence regarding risk factors for mortality and morbidity among pediatric HC patients. OBJECTIVE: To examine factors associated with all-cause mortality in children with HC after BMT/SCT. METHODS: The Pediatric Health Information System database was queried for patients with ICD-9/10 codes for hematopoietic transplant and gross hematuria, hematuria unspecified, or cystitis with hematuria...
February 15, 2024: Journal of Pediatric Urology
https://read.qxmd.com/read/38412093/the-genomic-and-evolutionary-landscapes-of-anaplastic-thyroid-carcinoma
#31
JOURNAL ARTICLE
Peter Y F Zeng, Stephenie D Prokopec, Stephen Y Lai, Nicole Pinto, Michelle A Chan-Seng-Yue, Roderick Clifton-Bligh, Michelle D Williams, Christopher J Howlett, Paul Plantinga, Matthew J Cecchini, Alfred K Lam, Iram Siddiqui, Jianxin Wang, Ren X Sun, John D Watson, Reju Korah, Tobias Carling, Nishant Agrawal, Nicole Cipriani, Douglas Ball, Barry Nelkin, Lisa M Rooper, Justin A Bishop, Cathie Garnis, Ken Berean, Norman G Nicolson, Paul Weinberger, Ying C Henderson, Christopher M Lalansingh, Mao Tian, Takafumi N Yamaguchi, Julie Livingstone, Adriana Salcedo, Krupal Patel, Frederick Vizeacoumar, Alessandro Datti, Liu Xi, Yuri E Nikiforov, Robert Smallridge, John A Copland, Laura A Marlow, Martin D Hyrcza, Leigh Delbridge, Stan Sidhu, Mark Sywak, Bruce Robinson, Kevin Fung, Farhad Ghasemi, Keith Kwan, S Danielle MacNeil, Adrian Mendez, David A Palma, Mohammed I Khan, Mushfiq Shaikh, Kara M Ruicci, Bret Wehrli, Eric Winquist, John Yoo, Joe S Mymryk, James W Rocco, David Wheeler, Steve Scherer, Thomas J Giordano, John W Barrett, William C Faquin, Anthony J Gill, Gary Clayman, Paul C Boutros, Anthony C Nichols
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes...
February 26, 2024: Cell Reports
https://read.qxmd.com/read/38410284/ring-finger-protein-34-rnf34-as-a-prognostic-biomarker-for-clear-cell-renal-cell-carcinoma
#32
JOURNAL ARTICLE
Johannes Stein, Niklas Klümper, Pirmin Zöhrer, Thomas Büttner, Philipp Krausewitz, Manuel Ritter, Glen Kristiansen, Marieta Toma, Jörg Ellinger, Alexander Cox
INTRODUCTION: Ring finger proteins play pivotal roles in diverse cellular processes and are implicated in contribution to cancer. Ring finger protein 34 (RNF34) has antiapoptotic and oncogenic properties. RNF34 is upregulated during carcinogenesis and tumor progression in the colorectal adenoma-carcinoma sequence and was already described to mediate chemoresistance. In clear cell renal cell carcinoma (ccRCC), however, the role and expression patterns of RNF34 are unknown. METHODS: First, we investigated the association of RNF34 mRNA expression with clinicopathological parameters and survival using data obtained from The Cancer Genome Atlas (TCGA) ccRCC cohort (N = 533)...
January 2024: Curēus
https://read.qxmd.com/read/38410124/progressive-improvement-in-5-year-survival-rates-for-extremity-soft-tissue-sarcomas-from-1999-to-2019
#33
JOURNAL ARTICLE
Ryley K Zastrow, Mohyeddine El Sayed, Christa L LiBrizzi, Andrew J Jacobs, Adam S Levin
BACKGROUND: Extremity soft-tissue sarcoma (ESTS) is a group of rare, heterogeneous malignancies. Previous studies have demonstrated a progressive improvement in 5-year survival rate over time, but recent trends are unknown. Therefore, this study aimed to provide an update on the clinical characteristics and 5-year survival rate of ESTS from 1999 to 2019. METHODS: This retrospective cohort study used the Surveillance, Epidemiology, and End Results (SEER) database...
2024: Sarcoma
https://read.qxmd.com/read/38403723/altered-biodistribution-of-68-ga-ga-dota-toc-during-somatostatin-analogue-treatment
#34
JOURNAL ARTICLE
T van de Weijer, F Bemer, J de Vos-Geelen, B Hermans, C Mitea, J A J van der Pol, T Lodewick, J E Wildberger, F M Mottaghy
PURPOSE: The need for an interval between the administration of long-acting Somatostatin Receptor Analogues (SSA) and the [68 Ga]Ga-DOTA-TATE PET has been questioned based on recent literature in the new EANM guidelines. Here an earlier studies showed that SSA injection immediately before SSTR PET had minimal effect on normal organ and tumor uptake (1). However, data are scarce and there are (small) differences between [68 Ga]Ga-DOTA-TATE and [68 Ga]Ga-DOTA-TOC binding affinity, and it remains unknown whether these findings can be directly translated to scans with [68 Ga]Ga-DOTA-TOC as well...
February 26, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38393464/utility-of-uv-signature-mutations-in-the-diagnostic-assessment-of-metastatic-head-and-neck-carcinomas-of-unknown-primary
#35
JOURNAL ARTICLE
Karina Colossi Furlan, Daryoush Saeed-Vafa, Tiffani M Mathew, James J Saller, Sana O Tabbara, Theresa A Boyle, Bruce M Wenig, Juan C Hernandez-Prera
BACKGROUND: Metastatic carcinoma of unknown primary origin to the head and neck lymph nodes (HNCUP) engenders unique diagnostic considerations. In many cases, the detection of a high-risk human papillomavirus (HR-HPV) unearths an occult oropharyngeal squamous cell carcinoma (SCC). In metastatic HR-HPV-independent carcinomas, other primary sites should be considered, including cutaneous malignancies that can mimic HR-HPV-associated SCC. In this context, ultraviolet (UV) signature mutations, defined as ≥ 60% C→T substitutions with ≥ 5% CC→TT substitutions at dipyrimidine sites, identified in tumors arising on sun exposed areas, are an attractive and underused tool in the setting of metastatic HNCUP...
February 23, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38390840/mir-10b-5p-promotes-tumor-growth-by-regulating-cell-metabolism-in-liver-cancer-via-targeting-slc38a2
#36
JOURNAL ARTICLE
Mingzhi Xia, Jie Chen, Yingyun Hu, Bin Qu, Qianqian Bu, Haoming Shen
Metabolic reprogramming plays a critical role in hepatocarcinogenesis. However, the mechanisms regulating metabolic reprogramming in primary liver cancer (PLC) are unknown. Differentially expressed miRNAs between PLC and normal tissues were identified using bioinformatic analysis. RT-qPCR was used to determine miR-10b-5p and SCL38A2 expression levels. IHC, WB, and TUNEL assays were used to assess the proliferation and apoptosis of the tissues. The proliferation, migration, invasion, and apoptosis of PLC cells were determined using the CCK-8 assay, Transwell assay, and flow cytometry...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38390329/mismatch-repair-gene-msh6-correlates-with-the-prognosis-immune-status-and-immune-checkpoint-inhibitors-response-of-endometrial-cancer
#37
JOURNAL ARTICLE
Lin-Zhi Zhou, Hong-Qi Xiao, Jie Chen
OBJECTIVE: Many patients treated with immune checkpoint inhibitors (ICIs) developed primary or secondary drug resistance for unknown reasons. This study investigates whether mismatch repair (MMR) genes are responsible for this therapeutic restriction. METHODS: We obtained the transcriptional, clinical and single nucleotide polymorphism data for endometrial cancer (EC) from The Cancer Genome Atlas and the immunophenoscore data of EC from The Cancer Immunome Atlas, then analyzed in R to evaluate the relationship between MMR genes and clinicopathological features, prognosis, immune infiltration, immune checkpoint expression and responsiveness to ICIs in EC...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38388496/alternative-wnt-signaling-axis-leads-to-a-break-of-oncogene-induced-senescence
#38
JOURNAL ARTICLE
Viola Kluge, Melanie Kappelmann-Fenzl, Stefan Fischer, Tom Zimmermann, Michaela Pommer, Silke Kuphal, Anja-Katrin Bosserhoff
Oncogene-induced senescence (OIS) is an important process that suppresses tumor development, but the molecular mechanisms of OIS are still under investigation. It is known that BRAFV600E -mutated melanocytes can overcome OIS and develop melanoma, but the underlying mechanism is largely unknown. Using an established OIS model of primary melanocytes transduced with BRAFV600E , YAP activity was shown to be induced in OIS as well as in melanoma cells compared to that in normal epidermal melanocytes. This led to the assumption that YAP activation itself is not a factor involved in the disruption of OIS...
February 22, 2024: Cell Death & Disease
https://read.qxmd.com/read/38384469/immune-cell-infiltrates-in-peritoneal-metastases-from-colorectal-cancer
#39
JOURNAL ARTICLE
Patrik Sundström, Stephen Hogg, Marianne Quiding Järbrink, Elinor Bexe Lindskog
BACKGROUND: The presence of peritoneal metastases (PMs) in patients with colorectal cancer (CRC) confers a poor prognosis and only a minority of patients will benefit from the available treatment options. In primary CRC tumors, it is well established that a high infiltration of CD8+ effector T cells correlates to a favorable patient outcome. In contrast, the immune response induced in PMs from CRC and how it relates to patient survival is still unknown. In this study, we characterized the immune infiltrates and the distribution of immune checkpoint receptors on T cells from PMs from CRC, in order to evaluate the potential benefit of checkpoint blockade immunotherapy for this patient group...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38381429/total-neoadjuvant-therapy-with-pd-1-blockade-for-high-risk-proficient-mismatch-repair-rectal-cancer
#40
JOURNAL ARTICLE
Yingjie Li, Chaohu Pan, Yuye Gao, Li Zhang, Dengbo Ji, Xiaoli Cui, Xiaoyan Zhang, Yong Cai, Yangzi Zhang, Yunfeng Yao, Lin Wang, Jiahua Leng, Tiancheng Zhan, Dongfang Wu, Zhibo Gao, Ying-Shi Sun, Zhongwu Li, Haitao Luo, Aiwen Wu
IMPORTANCE: Total neoadjuvant therapy (TNT) is the standard treatment for locally advanced rectal cancer, especially for patients with high-risk factors. However, the efficacy of TNT combined with immunotherapy for patients with proficient mismatch repair (pMMR) rectal cancer is unknown. OBJECTIVES: To evaluate the safety and efficacy of TNT with induction chemoimmunotherapy followed by long-course chemoradiation in patients with high-risk, pMMR rectal cancer and to identify potential molecular biomarkers associated with treatment efficacy...
February 21, 2024: JAMA Surgery
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