keyword
https://read.qxmd.com/read/38482714/clonal-analysis-of-metachronous-double-biliary-tract-cancers
#1
JOURNAL ARTICLE
Yuko Omori, Shuichi Aoki, Yusuke Ono, Takashi Kokumai, Shingo Yoshimachi, Hideaki Sato, Akiko Kusaka, Masahiro Iseki, Daisuke Douchi, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Yusuke Mizukami, Toru Furukawa, Michiaki Unno
The molecular mechanisms underpinning the development of metachronous tumors in the remnant bile duct following surgical resection of primary biliary tract carcinomas (BTCs) are unknown. This study aimed to elucidate these mechanisms by evaluating the clinicopathologic features of BTCs, the alterations to 31 BTC-related genes on targeted sequencing, and the aberrant expression of p53, p16, SMAD4, ARID1A and β-catenin on immunohistochemistry. Twelve consecutive patients who underwent resection of metachronous BTCs following primary BTC resection with negative bile duct margins were enrolled...
March 14, 2024: Journal of Pathology
https://read.qxmd.com/read/38482204/the-promising-role-of-mirnas-in-radioresistance-and-chemoresistance-of-nasopharyngeal-carcinoma
#2
REVIEW
Haoyuan Xu, Wanpeng Li, Dehui Wang
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor that develops in the nasopharynx. It has a distinct ethnic and geographical distribution, and emerging evidence suggests that it is an ecological disease. Most patients respond well to radiation combined with chemotherapy as the primary treatment for NPC. However, some patients will eventually develop radio resistance and chemoresistance, resulting in recurrence and metastasis, which is a primary cause of poor prognosis. The processes underlying radio resistance and chemoresistance in NPC are complex and unknown...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38480799/a-platform-independent-ai-tumor-lineage-and-site-atlas-classifier
#3
JOURNAL ARTICLE
Nicholas R Rydzewski, Yue Shi, Chenxuan Li, Matthew R Chrostek, Hamza Bakhtiar, Kyle T Helzer, Matthew L Bootsma, Tracy J Berg, Paul M Harari, John M Floberg, Grace C Blitzer, David Kosoff, Amy K Taylor, Marina N Sharifi, Menggang Yu, Joshua M Lang, Krishnan R Patel, Deborah E Citrin, Kaitlin E Sundling, Shuang G Zhao
Histopathologic diagnosis and classification of cancer plays a critical role in guiding treatment. Advances in next-generation sequencing have ushered in new complementary molecular frameworks. However, existing approaches do not independently assess both site-of-origin (e.g. prostate) and lineage (e.g. adenocarcinoma) and have minimal validation in metastatic disease, where classification is more difficult. Utilizing gradient-boosted machine learning, we developed ATLAS, a pair of separate AI Tumor Lineage and Site-of-origin models from RNA expression data on 8249 tumor samples...
March 13, 2024: Communications Biology
https://read.qxmd.com/read/38473827/first-in-class-humanized-antibody-against-alternatively-spliced-tissue-factor-augments-anti-metastatic-efficacy-of-chemotherapy-in-a-preclinical-model-of-pancreatic-ductal-adenocarcinoma
#4
JOURNAL ARTICLE
Clayton S Lewis, Charles Backman, Sabahat Ahsan, Ashley Cliff, Arthi Hariharan, Jen Jen Yeh, Xiang Zhang, Changchun Xie, Davendra P S Sohal, Vladimir Y Bogdanov
Alternatively spliced tissue factor (asTF) promotes the progression of pancreatic ductal adenocarcinoma (PDAC) by activating β1-integrins on PDAC cell surfaces. hRabMab1, a first-in-class humanized inhibitory anti-asTF antibody we recently developed, can suppress PDAC primary tumor growth as a single agent. Whether hRabMab1 has the potential to suppress metastases in PDAC is unknown. Following in vivo screening of three asTF-proficient human PDAC cell lines, we chose to make use of KRAS G12V-mutant human PDAC cell line PaCa-44, which yields aggressive primary orthotopic tumors with spontaneous spread to PDAC-relevant anatomical sites, along with concomitant severe leukocytosis...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38469292/an-unappreciated-cell-survival-independent-role-for-baff-initiating-chronic-lymphocytic-leukemia
#5
JOURNAL ARTICLE
Md Ashik Ullah, Beatriz Garcillán, Eden Whitlock, William A Figgett, Simona Infantino, Mahya Eslami, SiLing Yang, M Arifur Rahman, Yong H Sheng, Nicholas Weber, Pascal Schneider, Constantine S Tam, Fabienne Mackay
BACKGROUND: Chronic Lymphocytic Leukemia (CLL) is characterized by the expansion of CD19+ CD5+ B cells but its origin remains debated. Mutated CLL may originate from post-germinal center B cells and unmutated CLL from CD5+ mature B cell precursors. Irrespective of precursor types, events initiating CLL remain unknown. The cytokines BAFF and APRIL each play a significant role in CLL cell survival and accumulation, but their involvement in disease initiation remains unclear. METHODS: We generated novel CLL models lacking BAFF or APRIL...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38469019/erythromelalgia-secondary-to-anti-tumor-necrosis-factor-tnf-alpha-therapy-a-report-of-two-cases
#6
Fatima Zahra El Rhaoussi, Zineb Boukhal, Fouad Haddad, Mohamed Tahiri, Wafaa Hliwa, Ahmed Bellabah, Badre Wafaa
Erythromelalgia is a rare syndrome with a generally unknown etiology. Whether primary or secondary, this condition is characterized by paroxysmal episodes of erythema, pain, and heat in the extremities. We report two cases of erythromelalgia occurring after the initiation of treatment with infliximab. The first case involves a 38-year-old patient who had been followed since August 2022 for ileocolonic Crohn's disease classified as A2L3B3 according to the Montreal classification, which was resistant to treatment and required infliximab therapy...
February 2024: Curēus
https://read.qxmd.com/read/38466026/incidence-of-skeletal-related-events-in-patients-with-ewing-sarcoma-an-observational-retrospective-study-in-japan
#7
JOURNAL ARTICLE
Hisaki Aiba, Yuki Kojima, Tatsunori Shimoi, Kazuki Sudo, Shu Yazaki, Toru Imai, Akihiko Yoshida, Shintaro Iwata, Eisuke Kobayashi, Akira Kawai, Ayumu Arakawa, Chitose Ogawa, Hiroaki Kimura, Kan Yonemori
BACKGROUND: Skeletal-related events (SREs), including the pathological fracture, surgical treatment or radiation of bone lesions, malignant spinal cord compression, hypercalcemia, are important considerations when managing metastatic bone tumors; however, owing to their rarity, the incidence of SREs in patients with Ewing sarcoma remains unknown. METHODS: We retrospectively reviewed the clinical data from 146 patients with Ewing sarcoma treated at a single institution from 2005 to 2019...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38466015/neurological-autoimmunity-in-patients-with-non-pulmonary-neuroendocrine-neoplasms-clinical-manifestations-and-neural-autoantibody-profiles
#8
JOURNAL ARTICLE
Georgios Mangioris, Thorvardur R Halfdanarson, Vanda A Lennon, Bryce K Chang, Divyanshu Dubey, P James B Dyck, Eoin P Flanagan, Andrew McKeon, John R Mills, Sean J Pittock, Anastasia Zekeridou
BACKGROUND AND PURPOSE: Paraneoplastic neurological autoimmunity is well described with small-cell lung cancer, but information is limited for other neuroendocrine neoplasms (NENs). METHODS: Adult patients with histopathologically confirmed non-pulmonary NENs, neurological autoimmunity within 5 years of NEN diagnosis, and neural antibody testing performed at the Mayo Clinic Neuroimmunology Laboratory (January 2008 to March 2023) were retrospectively identified...
March 11, 2024: European Journal of Neurology
https://read.qxmd.com/read/38465160/the-clinicopathological-correlation-of-kras-mutation-and-pten-expression-status-in-primary-and-metastatic-colorectal-carcinoma
#9
JOURNAL ARTICLE
Redir T Hassan, Bashar Al Hassawi, Maysoon Alkazzaz
BACKGROUND: Colorectal cancer (CRC) research has identified a consistent loss of PTEN expression in both primary tumors and metastasis, highlighting its potential role in this disease. However, the impact of PTEN on downstream proteins of KRAS mutation, namely p-AKT, p-ERK, and p65 (NFkB), remains unknown. This study aims to explore the inhibitory effect of PTEN on KRAS downstream proteins and its correlation with pathological features in CRC patients. METHODS: From January 1, 2015, to December 31, 2021, 86 CRC cases were collected from governmental and private laboratories in the Duhok province...
February 2024: Curēus
https://read.qxmd.com/read/38463981/retrograde-tracing-of-breast-cancer-associated-sensory-neurons
#10
Svetllana Kallogjerovic, Inés Velázquez-Quesada, Rutva Hadap, Bojana Gligorijevic
Breast cancer is one of the leading causes of mortality among women. The tumor microenvironment, consisting of host cells and extracellular matrix, has been increasingly studied for its interplay with cancer cells, and the resulting effect on tumor progression. While the breast is one of the most innervated organs in the body, the role of neurons, and specifically sensory neurons, has been understudied, mostly for technical reasons. One of the reasons is the anatomy of sensory neurons: sensory neuron somas are located in the spine, and their axons can extend longer than a meter across the body to provide innervation in the breast...
March 1, 2024: bioRxiv
https://read.qxmd.com/read/38463586/expression-of-circular-rna-has-circ-0009158-and-identification-of-associated-mirna-mrna-network-in-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
Lili Sun, Buerlan Yeerkenbieke, Anwaier Yuemaierabola, Fuzhong Liu, Dilinaer Yeerxiati, Xiaogang Dong, Wenjia Guo
Primary hepatocellular carcinoma (HCC) affects people all over the world. Circular RNAs are involved in the growth and development of several malignancies and regulate a number of biological processes. However, the roles of has-circ-0009158 in HCC remain unknown. This study explored the expression and associated miRNA-mRNA network of has-circ-0009158 in HCC. Quantitative real-time polymerase chain reaction was used to measure the expression of hsa-circ-0009158 in the HCC tissues of 143 patients and four human HCC cell lines...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38461584/a-retroperitoneal-pseudomyxoma-of-the-appendix-a-case-report
#12
Souhaib Atri, Aifia Rany, Mahdi Hammami, Amine Sebai, Sarra Laabidi, Montassar Kacem
INTRODUCTION: Retroperitoneal pseudomyxoma (RP) is a rare condition characterized by mucinous tumor growth within the retroperitoneal space, commonly originating from the appendix or other abdominal organs. RP presents with non-specific symptoms such as abdominal pain, bloating, and weight loss, making accurate diagnosis challenging. Due to its rarity and symptom overlap with other conditions, RP requires careful management by a multidisciplinary healthcare team. CASE PRESENTATION: An 82-year-old female with a three-month history of abdominal pain and an abdominal mass underwent diagnostic imaging, revealing a retroperitoneal cystic mass...
March 8, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38460179/hepatocellular-carcinoma-linc01116-outcompetes-t-cells-for-linoleic-acid-and-accelerates-tumor-progression
#13
JOURNAL ARTICLE
Kun Ma, Junhui Chu, Yufeng Liu, Linmao Sun, Shuo Zhou, Xianying Li, Changyong Ji, Ning Zhang, Xinyu Guo, Shuhang Liang, Tianming Cui, Qingsong Hu, Jiabei Wang, Yao Liu, Lianxin Liu
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with a highly immunosuppressive tumor microenvironment and a typical pattern of disturbances in hepatic lipid metabolism. Long non-coding RNAs are shown to play an important role in the regulation of gene expression, but much remains unknown between tumor microenvironment and lipid metabolism as a bridging molecule. Here, long intergenic nonprotein coding RNA 01116 (LINC01116) acts as this molecular which is frequently upregulated in HCC patients and associated with HCC progression in vitro and in vivo is identified...
March 9, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38458429/tumor-intrinsic-galectin-3-suppresses-melanoma-metastasis
#14
JOURNAL ARTICLE
Norhan B B Mohammed, Lee Seng Lau, Joseph Souchak, Shi Qiu, Manmeet S Ahluwalia, Iman Osman, Charles J Dimitroff
Melanoma poses a poor prognosis with high mortality rates upon metastasis. Exploring molecular mechanisms governing melanoma progression paves the way for developing novel approaches to control melanoma metastasis and ultimately enhance patient survival rates. Extracellular galectin-3 (Gal-3) has emerged as a pleiotropic promoter of melanoma metastasis, exerting varying activities depending on its interacting partner. However, whether intracellular Gal-3 promotes melanoma aggressive behavior remains unknown...
March 6, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38456970/correlation-between-trophoblast-cell-surface-antigen-2-trop-2-expression-and-pathological-complete-response-in-patients-with-her2-positive-early-breast-cancer-treated-with-neoadjuvant-docetaxel-carboplatin-trastuzumab-and-pertuzumab
#15
JOURNAL ARTICLE
María Gion, Juan José García-Mosquera, José Manuel Pérez-García, Vicente Peg, Manuel Ruiz-Borrego, Agostina Stradella, Begoña Bermejo, José Antonio Guerrero, Laura López-Montero, Mario Mancino, José Rodríguez-Morató, Gabriele Antonarelli, Miguel Sampayo-Cordero, Antonio Llombart-Cussac, Javier Cortés
PURPOSE: The prognostic and predictive role of trophoblast cell-surface antigen-2 (Trop-2) overexpression in human epidermal growth factor receptor 2-positive (HER2-positive) breast cancer is currently unknown. We retrospectively analyzed Trop-2 expression and its correlation with clinicopathologic features and pathological complete response (pCR) in HER2-positive early breast cancer (EBC) patients treated with neoadjuvant docetaxel, carboplatin, trastuzumab, and pertuzumab in the PHERGain study...
March 8, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38451411/simultaneous-gastric-pancreatic-and-renal-metastasis-from-poorly-differentiated-hepatocellular-carcinoma
#16
JOURNAL ARTICLE
Manabu Uchikoshi, Takayoshi Ito, Yoko Nakajima, Ikuya Sugiura, Shoujirou Uozumi, Yuu Shimozuma, Masashi Sakaki, Yasuyuki Ohira, Toshiko Yamochi, Hitoshi Yoshida
Common extrahepatic metastasis sites of hepatocellular carcinoma (HCC) are the lungs, adrenal glands, and bones. Herein, we report a rare case of metastatic gastric, pancreatic, and renal tumors from HCC simultaneously, and review the relevant literature. A 75-year-old woman presented with right hypochondralgia, appetite loss, and weight loss. Computed tomography revealed suspected metastatic liver, lung, and renal tumors. A blood test revealed a leukocyte count of 26,210/μL and a high inflammatory reaction...
March 7, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38450293/smoking-as-a-risk-factor-for-very-late-recurrence-in-surgically-resected-early-stage-primary-hepatocellular-carcinoma
#17
JOURNAL ARTICLE
Wei-Ru Cho, Chih-Chi Wang, Mu-Jung Tsai, Chih-Che Lin, Yi-Hao Yen, Chien Hung Chen, Yuan-Hung Kuo, Chih-Chien Yao, Chao-Hung Hung, Pao-Yuan Huang, An-Che Liu, Ming-Chao Tsai
BACKGROUND: The risk of first recurrence of hepatocellular carcinoma (HCC) within years 5 to 10 after curative hepatectomy remains unknown. We aimed to assess the incidence and prognostic factors for very late recurrence among patients who achieved 5 years' recurrence-free survival (RFS) after primary resection. METHODS: We retrospectively analyzed 337 patients with early-stage HCC underwent primary tumor resection and achieved more than 5 years' RFS...
2024: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/38449408/-a-patient-with-cancer-of-unknown-primary-who-responded-to-chemotherapy
#18
JOURNAL ARTICLE
Akira Takama, Manabu Iwadate, Shigeyuki Tsukita, Hiromichi Ohira
Cancer of unknown primary is a class of malignant tumors, histologically identified as metastatic lesions whose primary origin is unknown despite adequate investigations for the primary tumor. Although the prognosis of cancer of unknown primary is generally poor, here, we report our experience with a patient who responded to chemotherapy. The patient was a 78-year-old woman. She had a history of gastric cancer at the age of 76 years. In June of year X-1, she was diagnosed with gastric cancer(tub1>tub2, pT1bN0M0, pStage Ⅰa)and underwent distal gastrectomy...
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38449403/-case-of-a-patient-with-cancer-of-unknown-primary-in-the-poor-prognosis-group-who-had-a-experienced-a-beneficial-treatment-course
#19
JOURNAL ARTICLE
Takashi Jin, Toshizo Takayama, Yusuke Tomita, Koya Sawai, Rio Honma, Hiroko Takeda, Yasushi Tsuji
A 47-year-old woman with general malaise and abdominal pain presented with multiple liver tumors and lymph node metastasis. She was diagnosed with small cell carcinoma on the basis of a lymph node biopsy; however, the primary lesion was not identified. Finally, we diagnosed her with cancer of unknown primary lesion and placed her in the poor prognosis group. Although her general condition was poor, she experienced a relatively good response to treatment for small cell carcinoma.
February 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/38439727/merkel-cell-carcinoma-of-unknown-primary-origin
#20
JOURNAL ARTICLE
Helena Francetić, Luka Simetić, Čedna Tomasović Lončarić, Daška Štulhofer Buzina, Romana Čeović
Merkel cell carcinoma (MCC) is a rare and highly aggressive primary cutaneous neuroendocrine carcinoma most often occurring in the elderly. Risk factors include chronic sun exposure and immunosuppression (1). MCC is associated with frequent recurrences and a high metastatic potential and mortality rate (1). It is the second most common cause of skin-cancer-related death after melanoma. At primary diagnosis with an apparent cutaneous tumor, loco-regional metastases are present in up to 30% of patients, and 6-12% have distant metastatic disease (2-3)...
December 2023: Acta Dermatovenerologica Croatica: ADC
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