Gulam A Manji, Shing Lee, Armando Del Portillo, Michael May, Sarah Sta Ana, Emily Alouani, Naomi Sender, Tiffany Negri, Katarzyna Gautier, Liner Ge, Weijia Fan, Mengyu Xie, Amrita Sethi, Beth Schrope, Aik Choon Tan, Haeseong Park, Paul E Oberstein, Manish A Shah, Alexander G Raufi
IMPORTANCE: Combining immune checkpoint blockade (ICB) with chemotherapy improves outcomes in patients with metastatic gastric and gastroesophageal junction (G/GEJ) adenocarcinoma; however, whether this combination has activity in the perioperative setting remains unknown. OBJECTIVE: To evaluate the safety and preliminary activity of perioperative chemotherapy and ICB followed by maintenance ICB in resectable G/GEJ adenocarcinoma. DESIGN, SETTING, AND PARTICIPANTS: This investigator-initiated, multicenter, open-label, single-stage, phase 2 nonrandomized controlled trial screened 49 patients and enrolled 36 patients with resectable G/GEJ adenocarcinoma from February 10, 2017, to June 17, 2021, with a median (range) follow-up of 35...
December 1, 2023: JAMA Oncology