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Procalcitonine

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https://www.readbyqxmd.com/read/29456727/risk-factors-and-coping-strategies-of-severe-community-acquired-pneumonia-in-chemotherapy-induction-period-of-acute-leukemia
#1
Ning Li, Qingcheng Duan, Weidan Zhang
The risk factors and coping strategies of severe community-acquired pneumonia (SCAP) in chemotherapy induction period of acute leukemia were investigated. Eighty-six patients with CAP in chemotherapy induction period of acute leukemia in Dezhou Hospital from March 2014 to February 2017 were selected and divided into observation group (SCAP group, n=45) and control group (non-SCAP group, n=41) according to the acute physiology and chronic health evolution II (APACHE II) score. The blood, sputum, nasopharyngeal secretion and pleural effusion samples were collected from patients in both groups, and the samples were detected for pathogens, followed by the analysis of relevant factors...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456701/correlation-between-cortisol-levels-and-concurrent-infection-for-hepatitis-b-cirrhosis-patients-and-countermeasure-analysis
#2
Jian Zhang, Junwei Ma, Hongxin Wang, Junhong Li
The study assessed the correlation between cortisol (COR) levels and concurrent infection for the patients with hepatitis B cirrhosis for corresponding countermeasure analysis. In total, 86 patients with hepatitis B cirrhosis (non-infection group) and 32 patients with hepatitis B cirrhosis complicated with infection (infection group) who were diagnosed and treated in the Beijing YouAn Hospital from March 2014 to March 2017 were selected. The fasting venous blood of all the patients was drawn to detect COR, cortisol binding globulin (CBG), blood routine indexes, C-reactive protein (CRP), procalcitonin (PCT), endotoxin and other indicators...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29435167/pentraxin-3-procalcitonin-and-lactate-as-prognostic-markers-in-patients-with-sepsis-and-septic-shock
#3
Chenggong Hu, Yongfang Zhou, Chang Liu, Yan Kang
The purpose of this study was to confirm the prognostic value of pentraxin-3 (PTX3), procalcitonin (PCT) and lactate in patients with severe infections requiring ICU management and to develop and validate a model to enhance mortality prediction by combining severity scores with biomarkers. We included 141 patients with the diagnosis of sepsis/septic shock. The levels of PTX3, PCT and lactate were measured on day 0, 3, 7 of hospitalization and Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were also evaluated...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29433841/relationship-between-acute-kidney-injury-and-serum-procalcitonin-pct-concentration-in-critically-ill-patients-with-influenza-infection
#4
A Rodríguez, L F Reyes, J Monclou, B Suberviola, M Bodí, G Sirgo, J Solé-Violán, J Guardiola, D Barahona, E Díaz, I Martín-Loeches, M I Restrepo
INTRODUCTION: Serum procalcitonin (PCT) concentration could be increased in patients with renal dysfunction in the absence of bacterial infection. OBJECTIVE: To determine the interactions among serum renal biomarkers of acute kidney injury (AKI) and serum PCT concentration, in patients admitted to the intensive care unit (ICU) due to lung influenza infection. DESIGN: Secondary analysis of a prospective multicentre observational study. SETTING: 148 Spanish ICUs...
February 9, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29427369/pre-eclampsia-affects-procalcitonin-production-in-placental-tissue
#5
Chiara Agostinis, Damiano Rami, Paola Zacchi, Fleur Bossi, Tamara Stampalija, Alessandro Mangogna, Leonardo Amadio, Romana Vidergar, Liza Vecchi Brumatti, Giuseppe Ricci, Claudio Celeghini, Oriano Radillo, Ian Sargent, Roberta Bulla
PROBLEM: Procalcitonin (PCT) is the prohormone of calcitonin which is usually released from neuroendocrine cells of the thyroid gland (parafollicular) and the lungs (K cells). PCT is synthesized by almost all cell types and tissues, including monocytes and parenchymal tissue, upon LPS stimulation. To date, there is no evidence for PCT expression in the placenta both in physiological and pathological conditions. METHOD: Circulating and placental PCT levels were analysed in pre-eclamptic (PE) and control patients...
February 10, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29419698/next-generation-sequencing-diagnostics-of-bacteremia-in-sepsis-next-genesis-trial-study-protocol-of-a-prospective-observational-noninterventional-multicenter-clinical-trial
#6
MULTICENTER STUDY
Thorsten Brenner, Sebastian O Decker, Silke Grumaz, Philip Stevens, Thomas Bruckner, Thomas Schmoch, Mathias W Pletz, Hendrik Bracht, Stefan Hofer, Gernot Marx, Markus A Weigand, Kai Sohn
BACKGROUND: Sepsis remains a major challenge, even in modern intensive care medicine. The identification of the causative pathogen is crucial for an early optimization of the antimicrobial treatment regime. In this context, culture-based diagnostic procedures (e.g., blood cultures) represent the standard of care, although they are associated with relevant limitations. Accordingly, culture-independent molecular diagnostic procedures might be of help for the identification of the causative pathogen in infected patients...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29413717/sustained-increase-in-angiopoietin-2-heparin-binding-protein-and-procalcitonin-is-associated-with-severe-sepsis
#7
Xiao-Wei Liu, Tao Ma, Wei Liu, Quan Cai, Li Wang, Hong-Wei Song, Liao Yuan, Zhi Liu
PURPOSE: The identification of infection at its early stage in vulnerable patients is challenging. This study aimed to investigate potential biomarkers to distinguish patients progressing to severe sepsis from those with uncomplicated sepsis. MATERIALS AND METHODS: Serum samples were collected from sepsis patients admitted to the emergency department. The mRNA and protein levels of angiopoietin-2 (Ang-2), interleukin-10 (IL-10), heparin-binding protein (HBP), procalcitonin (PCT), adrenomedullin (ADM), and interleukin-6 (IL-6) were evaluated...
January 11, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29404940/impact-of-procalcitonin-guidance-on-management-of-adults-hospitalized-with-chronic-obstructive-pulmonary-disease-exacerbations
#8
Derek N Bremmer, Briana E DiSilvio, Crystal Hammer, Moeezullah Beg, Swati Vishwanathan, Daniel Speredelozzi, Matthew A Moffa, Kurt Hu, Rasha Abdulmassih, Jina T Makadia, Rikinder Sandhu, Mouhib Naddour, Noreen H Chan-Tompkins, Tamara L Trienski, Courtney Watson, Terrence J Obringer, Jim Kuzyck, Thomas L Walsh
BACKGROUND: Antibiotics are often prescribed for hospitalized patients with chronic obstructive pulmonary disease (COPD) exacerbations. The use of procalcitonin (PCT) in the management of pneumonia has safely reduced antibiotic durations, but limited data on the impact of PCT guidance on the management of COPD exacerbations remain. OBJECTIVE: To determine the impact of PCT guidance on antibiotic utilization for hospitalized adults with exacerbations of COPD. DESIGN: A retrospective, pre-/post-intervention cohort study was conducted to compare the management of patients admitted with COPD exacerbations before and after implementation of PCT guidance...
February 5, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29402370/-impact-of-permissive-underfeeding-versus-standard-enteral-feeding-on-outcomes-in-critical-patients-requiring-mechanical-ventilation-a-prospective-randomized-controlled-study
#9
Nianbin Ma, Mingfu Shen, Zhen Wan, Sijun Pan, Xian Liu, Zhongxiang Yao
OBJECTIVE: To compare the impact of permissive underfeeding versus standard enteral feeding on outcomes in critical patients requiring mechanical ventilation (MV). METHODS: A prospective randomized controlled study was conducted. Eighty-two patients requiring MV admitted to intensive care unit (ICU) of Anji People's Hospital from January 2015 to March 2017 were enrolled, and they were randomly divided into the permissive underfeeding group (n = 40, non-protein heat was 52...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29400303/acute-generalized-exanthematous-pustulosis-associated-with-helicobacter-pylori-eradication-therapy-with-elevated-serum-procalcitonin
#10
Yuki Yamazaki, Risa Watanabe, Takahiro Ishikawa, Takichi Munetsugu, Aya Nishizawa, Takahiro Satoh
No abstract text is available yet for this article.
February 1, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29399761/kinetics-of-common-inflammatory-biomarkers-in-postoperative-course-after-congenital-heart-defects-procedures-with-extracorporeal-circulation-in-children
#11
Ireneusz Haponiuk, Radosław Jaworski, Konrad Paczkowski, Maciej Chojnicki, Mariusz Steffens, Aneta Szofer-Sendrowska, Katarzyna Gierat-Haponiuk, Ewelina Kwaśniak, Marta Paśko-Majewska, Katarzyna Leszczyńska, Jacek Zieliński, Wiktor Szymanowicz
BACKGROUND: The extracorporeal circulation is associated with systemic inflammatory response syndrome. Therefore, the diagnosis of infection should be differenced from typical postoperative course. AIM: Evaluation of kinetics of inflammatory biomarkers in children in the first days after cardiac surgery with extracorporeal circulation. METHODS: Prospective data collection from 51 consecutive children referred for surgical treatment [the Institution], between February 2015 and August 2015...
February 5, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29399566/predictive-value-of-procalcitonin-for-infection-and-survival-in-adult-cardiogenic-shock-patients-treated-with-extracorporeal-membrane-oxygenation
#12
Do Wan Kim, Hwa Jin Cho, Gwan Sic Kim, Sang Yun Song, Kook Joo Na, Sang Gi Oh, Bong Suk Oh, In Seok Jeong
Procalcitonin (PCT) is a predictive marker for the occurrence of bacterial infection and the decision to terminate antibiotic treatment in critically ill patients. An unusual increase in PCT, regardless of infection, has been observed during extracorporeal membrane oxygenation (ECMO) support. We evaluated trends and the predictive value of PCT levels in adult cardiogenic shock during treatment with ECMO. We reviewed the clinical records of 38 adult cardiogenic shock patients undergoing veno-arterial ECMO support between January 2014 and December 2016...
January 2018: Chonnam Medical Journal
https://www.readbyqxmd.com/read/29399119/expression-of-mmp-2-and-timp-1-in-cerebrospinal-fluid-and-the-correlation-with-dynamic-changes-of-serum-pct-in-neonatal-purulent-meningitis
#13
Huilan Chen, Fei Wu, Rong Fu, Xiangchun Feng
Matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in cerebrospinal fluid of pediatric patients with neonatal purulent meningitis were observed to analyze changes in serum procalcitonin (PCT) and the correlation among the three factors (MMP-2, TIMP-1 and PCT). Sixty pediatric patients with neonatal purulent meningitis from April 2015 to December 2016 were enrolled as the purulent meningitis group and 60 pediatric patients with viral encephalitis treated during the same period were enrolled as the viral encephalitis group...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29397831/-comparison-of-diagnosis-values-of-cd64-infection-index-crp-pct-and-neu-in-the-leukemia-complicated-with-bacterial-infection
#14
Xiao-Yan Guo, Yun-Kai Kang, Shu-Xia Guo
OBJECTIVE: To compare the diagnostic values of CD64 infection index, C-reactive protein (CRP), procalcitonin (PCT) and the percentage of neutrophils (NEU%) in leukemia patients complicated with bacterial infection. METHODS: Sixty cases of leukemia complicated with bacterial infection (combination with infection group), 60 cases of leukemia without bacterial infection (non-combination with infection group) and 60 cases of healthy persons (control group) were selected in our hospital...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29396775/new-biomarkers-to-diagnose-ventilator-associated-pneumonia-pentraxin-3-and-surfactant-protein-d
#15
Nazan Ulgen Tekerek, Basak Nur Akyildiz, Baris Derya Ercal, Sabahattin Muhtaroglu
OBJECTIVE: To detect the most effective biomarker to confirm ventilator associated pneumonia (VAP). METHODS: Fifty patients with VAP suspicious diagnosis and 30 healthy patients were recruited. Suspicion of VAP was established if patients met the modified CPIS score ≥ 6 points. The confirmation of VAP was defined by the quantitative culture of nonbronchoscopic bronchoalveolar lavage (BAL) >105 CFU/ml of pathogenic microorganism. Serum samples for determination of C-reactive protein (CRP), procalcitonin (PCT), pentraxin 3 (PTX3), surfactant protein D (SPD) were collected on suspected VAP...
February 2, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29385638/procalcitonin-and-c-reactive-protein-may-help-to-detect-invasive-bacterial-infections-in-children-who-have-fever-without-source
#16
Gaëlle Hubert-Dibon, Lou Danjou, Cécile Feildel-Fournial, Bénédicte Vrignaud, Damien Masson, Elise Launay, Christèle Gras-Le Guen
AIM: This study evaluated the epidemiology and performance of biomarkers for identifying bacterial infections in children who presented with fever without source. METHODS: We conducted a prospective cohort study in the paediatric department at the University Hospital of Nantes, France, in 2016. Children older than six days and younger than five years of age were included. RESULTS: A total of 1,060 children (52.2% male) with fever without source were admitted and the median age was 17 months (interquartile range 6...
January 31, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29384919/clinical-significance-of-measuring-reticulated-platelets-in-infectious-diseases
#17
Qin-Hua Liu, Ming-Yue Song, Bai-Xia Yang, Rui-Xiang Xia
This study aimed to explore the association between the percentage of reticulated platelets (RP%) and infection, and analyze the value of combined measurement of RP% with other inflammatory indicators in diagnosing infection. A total of 190 patients with signs and symptoms suspicious of infection were included in the infection group, and 70 healthy subjects with comparable percentages of gender and age were included in the control group. Peripheral white blood cell (WBC) count, percentage of neutrophils (N%), platelet count, C-reactive protein (CRP), procalcitonin (PCT), RP%, and axillary temperature were recorded...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29384315/the-efficacy-of-parenteral-fish-oil-in-critical-illness-patients-with-sepsis-a-prospective-non-randomized-observational-study
#18
Wen-Si Li, Zhang-Zhang Chen, Yi-Jun Zheng, Ming Zhong, Jie-Fei Ma, Li-Zhen Xuan, Jie-Qiong Song, Qian-Zhou Lv, Du-Ming Zhu
BACKGROUND AND OBJECTIVES: To investigate the clinical outcomes in septic patients receiving parenteral fish oil. METHODS AND STUDY DESIGN: A prospective, non-randomized, observational clinical study was carried out in 112 patients with sepsis from March, 2013 to May, 2015 in the surgical intensive care unit (SICU) of a tertiaryreferral hospital. The patients were put into one of two groups; either the control or the study group. Patients received the standard treatment of sepsis based on guidelines in the control group...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29383956/the-macrophage-activation-marker-smr-as-a-diagnostic-and-prognostic-marker-in-patients-with-acute-infectious-disease-with-or-without-sepsis
#19
Mette Marie Relster, Shahin Gaini, Holger Jon Møller, Isik Somuncu Johansen, Court Pedersen
Sepsis is a leading cause of mortality. This study aims to assess the utility of the soluble mannose receptor (sMR) as a biomarker of sepsis and mortality in patients hospitalized with suspected infection. Using an in-house ELISA assay the concentration of sMR was analyzed in the serum of patients from three prospective studies. Using Sepsis-3 guidelines, patients were stratified as no infection (NI, n = 68), verified infection without sepsis (NSEP, n = 133) and verified infection with sepsis (SEP, n = 190)...
January 31, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29382396/higher-cut-off-serum-procalcitonin-level-for-sepsis-diagnosis-in-metastatic-solid-tumor-patients
#20
Segal Abdul Aziz, Erni Juwita Nelwan, Lugyanti Sukrisman, Suhendro Suhendro
OBJECTIVE: The current study aimed to know procalcitonin levels in patients with metastatic tumor, and to discover the cut-off point for sepsis in this population. A cross-sectional study was conducted with patients with solid tumor. Sepsis and systemic inflammation response syndrome (SIRS) were identified using clinical, laboratory, and microbiological criteria. The cut-off point was determined using receiver operating characteristic (ROC) curve. RESULTS: A total of 112 subjects enrolled in this study, 51% male, mean age 47...
January 30, 2018: BMC Research Notes
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