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Procalcitonine

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https://www.readbyqxmd.com/read/29684670/evaluation-of-the-bisap-scoring-system-in-prognostication-of-acute-pancreatitis-a-prospective-observational-study
#1
Sumitra Hagjer, Nitesh Kumar
INTRODUCTION: Severe acute pancreatitis has a high mortality and its early identification is important for management and risk stratification. The bedside index for severity in acute pancreatitis (BISAP) is a simple scoring system done at admission which predicts the severity of pancreatitis. Procalcitonin is an inflammatory marker which is raised very early and helps in early prediction of the severity of disease. This study aims to evaluate the BISAP score and Procalcitonin in prognostication of acute pancreatitis...
April 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29683405/longitudinal-evaluation-of-plasma-concentrations-of-presepsin-in-patients-after-severe-trauma-a-prospective-observational-study
#2
Christian Koch, Sophie Ruhrmann, Michael Pöhlmann, Emmanuel Schneck, Borros Arneth, Thomas Zajonz, Michael Sander, Markus A Weigand, Florian Uhle
BACKGROUND: The high mortality rate of patients suffering from severe trauma is based not only on the mechanism of injury, but also on the higher risk for development of subsequent infections. Therefore, the early recognition of infection after severe trauma is of particular importance for patient outcome. However, early diagnosis is often masked by the consequences of the sterile, damage-triggered immune response. Our study sought to analyze the course of soluble CD14-subtype (sCD14-ST, presepsin) compared with clinically established inflammatory and infectious biomarkers in a cohort of patients with severe trauma...
April 23, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29682292/plasma-procalcitonin-concentrations-are-increased-in-dogs-with-sepsis
#3
Robert Goggs, Matthew Milloway, Roberta Troia, Massimo Giunti
Sepsis, the life-threatening organ dysfunction caused by a dysregulated host response to infection, is difficult to identify and to prognosticate for. In people with sepsis, procalcitonin (PCT) measurement aids diagnosis, enables therapeutic monitoring and improves prognostic accuracy. This study used a commercial canine PCT assay to measure plasma PCT concentrations in dogs with gastric dilatation volvulus (GDV) syndrome and in dogs with sepsis. It was hypothesised that dogs with GDV syndrome and with sepsis have greater plasma PCT concentrations than healthy dogs and that dogs with sepsis have greater PCT concentrations than dogs with GDV syndrome...
2018: Veterinary Record Open
https://www.readbyqxmd.com/read/29680395/plasma-procalcitonin-concentration-in-healthy-calves-and-those-with-septic-systemic-inflammatory-response-syndrome
#4
F Bonelli, V Meucci, T J Divers, A Boccardo, D Pravettoni, M Meylan, A G Belloli, M Sgorbini
The diagnosis of sepsis in calves is challenging. Blood culture and clinical signs combined with a complete blood count have been used for the diagnosis of sepsis. Recent literature in humans and animal species has been focused on sepsis-specific biomarkers, such as procalcitonin (PCT), that may more accurately and efficiently diagnose sepsis. The aim of this study was to evaluate plasma PCT concentrations in healthy and septic calves. Twenty healthy control calves and 58 sick calves with septic systemic inflammatory response syndrome (SIRS) based on SIRS score and clinical findings were included...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29679091/excluding-severe-bacterial-infection-in-neutrophilic-dermatoses-with-systemic-manifestations-negative-predictive-value-of-procalcitonin
#5
Pei Ming Yeo, Yik Weng Yew, Hong Liang Tey
No abstract text is available yet for this article.
March 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29675987/the-usage-of-procalcitonin-in-finland
#6
B Tujula, M Kokki, K Pulkki, J Romppanen, S Sjövall, H Tuominen, H Kokki
BACKGROUND: We have surveyed the use of procalcitonin (PCT) in Finland with a specific emphasis on intensive care unit (ICU) patients. METHODS: The PCT use was surveyed from all 11 laboratories providing services for all 15 secondary and all five tertiary care hospitals in Finland. The laboratories reported the PCT use of each hospital in 2014 and 2015. Four hospitals were analysed for the first 100 adult ICU patients with PCT measurements in 2015. The indication for PCT measurement and whether PCT values affected antibiotic treatment were collected from patient records...
April 19, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29675434/the-role-of-serum-procalcitonin-interleukin-6-and-fibrinogen-levels-in-differential-diagnosis-of-diabetic-foot-ulcer-infection
#7
Pınar Korkmaz, Havva Koçak, Kevser Onbaşı, Polat Biçici, Ahmet Özmen, Cemile Uyar, Duru Mıstanoğlu Özatağ
Aims: We aimed to evaluate the roles of interleukin-6 (IL-6), PCT, and fibrinogen levels in the differential diagnosis of the patients with infected diabetic foot ulcer (IDFU) and noninfected diabetic foot ulcer (NIDFU) and to compare those with C-reactive protein (CRP), white blood cell (WBC), and erythrocyte sedimentation rate (ESR). Methods: Patients over 18 years with a diagnosis of type 2 diabetes mellitus and DFU who were followed up in our hospital between 1 January 2016 and 1 January 2017 were included in the study...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29674672/author-correction-procalcitonin-guiding-antimicrobial-therapy-duration-in-febrile-cancer-patients-with-documented-infection-or-neutropenia
#8
Hanine El Haddad, Anne-Marie Chaftari, Ray Hachem, Majd Michael, Ying Jiang, Ammar Yousif, Sammy Raad, Mary Jordan, Patrick Chaftari, Issam Raad
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29671149/biological-scoring-system-for-early-prediction-of-acute-bowel-ischemia-after-cardiac-surgery-the-palm-score
#9
Elie Zogheib, Cyril Cosse, Charles Sabbagh, Simon Marx, Thierry Caus, Marc Henry, Joseph Nader, Mathurin Fumery, Michael Bernasinski, Patricia Besserve, Faouzi Trojette, Cedric Renard, Pierre Duhaut, Said Kamel, Jean-Marc Regimbeau, Hervé Dupont
BACKGROUND: Bowel ischemia is a life-threatening emergency defined as an inadequate vascular perfusion leading to bowel inflammation resulting from impaired colonic/small bowel blood supply. Main issue for physicians regarding bowel ischemia diagnosis lies in the absence of informative and specific clinical or biological signs leading to delayed management, resulting in a poorer prognosis, especially after cardiac surgery. The aim of the present series was to propose a simple scoring system based on biological data for the diagnosis of bowel ischemia...
April 18, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29668936/biomarkers-of-sepsis-and-bloodstream-infections-the-role-of-procalcitonin-and-proadrenomedullin-with-emphasis-in-patients-with-cancer
#10
Hanine El Haddad, Anne-Marie Chaftari, Ray Hachem, Patrick Chaftari, Issam I Raad
Sepsis and bloodstream infections remain a leading cause of death in immunocompromised cancer patients. The management of these serious infections consist of empiric use of antimicrobial agents which are often overused. Procalcitonin and proadrenomedullin are biomarkers that have been extensively evaluated in the general populations with little emphasis in the immunocompromised cancer patient population where they may have promising roles in the management of febrile patients. In this review, we summarize the available evidence of the potential role of these available biomarkers in guiding antimicrobial therapy to optimize resource utilization in the general patient population...
April 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29667377/the-usefulness-of-determination-of-the-procalcitonin-pct-concentration-in-gbs-piositive-pregnant-womens-blood-serum-for-anticipations-of-infections-in-newborns
#11
Wojciech Cnota, Dominika Mucha, Jan Mucha
Group-B streptococci (GBS) are commensal bacteria of the human body. They may, however, pose a serious life hazard to pregnant women. During labour, newborns of GBS-positive mothers run the risk of infections that may eventually lead to severe complications, sepsis or even death. For this reason, it is very important to find new diagnostic markers that will enable fast and effective diagnostics and control of the disease process. The level of procalcitonin emerges as a promising diagnostic parameter. AIM. Analysis of the impact of the procalcitonin (PCT) level in GBS-positive pregnant women on the possibility of complications and infections in mothers and newborns MATERIAL AND METHODS...
2018: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29667256/procalcitonin-and-c-reactive-protein-as-biomarkers-for-neonatal-bacterial-infection
#12
Ashfaque F Quadir, Philip N Britton
AIM: Neonates are predisposed to bacterial infection which are an important cause of early childhood morbidity and mortality globally. It has been proposed that procalcitonin has significant utility as a diagnostic marker for bacterial infection in febrile neonates when compared to C-reactive protein (CRP). The aim of this study is to conduct a literature search to find the best available evidence to answer the clinical question of the utility of procalcitonin when compared to CRP as a predictor of bacterial infection in febrile neonates...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29663997/-predictive-value-of-inflammatory-markers-for-acute-kidney-injury-in-sepsis-patients-analysis-of-753-cases-in-7-years
#13
Xiao Zhou, Jingfeng Liu, Xiaojun Ji, Xiaowei Yang, Meili Duan
OBJECTIVE: To evaluate different inflammation markers for predicting the risk of acute kidney injury (AKI) in sepsis patients. METHODS: A retrospective observational study was conducted. The adult patients with sepsis for more than 24 hours admitted to intensive care unit (ICU) of Beijing Friendship Hospital, Capital Medical University from March 1st, 2010 to November 1st, 2017 were enrolled. Inflammatory markers such as white blood cell count (WBC), erythrocyte sedimentation rata (ESR), neutrophil and lymphocyte ratio (NLR), C-reactive protein (CRP), procalcitonin (PCT), etc...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663995/-risk-factors-of-atrial-fibrillation-in-critical-ill-patients
#14
Jianyu Fu, Hongying Bi, Yunsong Xia, Hui Fang, Xu Liu, Yan Tang, Difen Wang
OBJECTIVE: To observe the clinical features of atrial fibrillation (AF) patients, and to explore the correlation between the routine detection index and the new-onset AF and to find out risk factors for new AF in critically ill patients. METHODS: A prospective observational study was conducted. The patients with AF admitted to intensive care unit (ICU) of the Affiliated Hospital of Guizhou Medical University from March 2016 to June 2017 were enrolled. The patients were divided into new-onset AF group and past-existed AF group according to their past history of AF (including persistent AF, paroxysmal AF or permanent AF)...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663841/novel-heart-failure-biomarkers-why-do-we-fail-to-exploit-their-potential
#15
Arnold Piek, Weijie Du, Rudolf A de Boer, Herman H W Silljé
Plasma biomarkers are useful tools in the diagnosis and prognosis of heart failure (HF). In the last decade, numerous studies have aimed to identify novel HF biomarkers that would provide superior and/or additional diagnostic, prognostic, or stratification utility. Although numerous biomarkers have been identified, their implementation in clinical practice has so far remained largely unsuccessful. Whereas cardiac-specific biomarkers, including natriuretic peptides (ANP and BNP) and high sensitivity troponins (hsTn), are widely used in clinical practice, other biomarkers have not yet proven their utility...
April 17, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29663044/procalcitonin-algorithm-to-guide-initial-antibiotic-therapy-in-acute-exacerbations-of-copd-admitted-to-the-icu-a-randomized-multicenter-study
#16
Cédric Daubin, Xavier Valette, Fabrice Thiollière, Jean-Paul Mira, Pascal Hazera, Djillali Annane, Vincent Labbe, Bernard Floccard, François Fournel, Nicolas Terzi, Damien Du Cheyron, Jean-Jacques Parienti
PURPOSE: To compare the efficacy of an antibiotic protocol guided by serum procalcitonin (PCT) with that of standard antibiotic therapy in severe acute exacerbations of COPD (AECOPDs) admitted to the intensive care unit (ICU). METHODS: We conducted a multicenter, randomized trial in France. Patients experiencing severe AECOPDs were assigned to groups whose antibiotic therapy was guided by (1) a 5-day PCT algorithm with predefined cutoff values for the initiation or stoppage of antibiotics (PCT group) or (2) standard guidelines (control group)...
April 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29658977/a-systematic-review-and-meta-analysis-of-procalcitonin-as-a-marker-of-postoperative-orthopedic-infections
#17
Ross B Ingber, Abduljabbar Alhammoud, Daniel P Murray, Roby Abraham, Anant Dixit, Qais Naziri, Ghalib Ahmed, Carl B Paulino, William P Urban, Chad Craig, Aditya V Maheshwari, Bassel G Diebo
Procalcitonin is a serologic marker that increases in response to inflammatory stimuli, especially those of bacterial origin. Postoperative orthopedic periprosthetic infections are often difficult to diagnose. This study systematically reviewed the literature to evaluate the statistical measures of performance of procalcitonin as a marker of postoperative orthopedic infection. This study showed that procalcitonin has a weighted pooled sensitivity of 67.3%, specificity of 69.4%, positive likelihood ratio of 1...
April 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29658355/procalcitonin-and-albumin-as-prognostic-biomarkers-in-elderly-patients-with-a-risk-of-bacterial-infection
#18
Toshihiro Higashikawa, Masashi Okuro, Keiichirou Ishigami, Kunihiro Mae, Ryusho Sangen, Takurou Mizuno, Daisuke Usuda, Atushi Saito, Yuji Kasamaki, Akihiro Fukuda, Hitoshi Saito, Shigeto Morimoto, Tsugiyasu Kanda
Aim This study was performed to investigate serum procalcitonin (PCT) and albumin (Alb) as prognostic biomarkers in elderly patients at risk of bacterial infection. Methods Serum PCT was measured in 270 hospitalized patients (mean age, 77.4 years) with suspected bacterial infection. The PCT-negative (<0.5 ng/mL) and PCT-positive (≥0.5 ng/mL) groups comprised 155 and 115 patients, respectively. Logistic regression analysis was performed with various clinical laboratory test values as independent variables and PCT positivity/negativity as the dependent variable...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29656512/procalcitonin-a-feasible-biomarker-for-severe-bacterial-infections-in-obstetrics-and-gynecology
#19
EDITORIAL
Benita Tujula, Hannu Kokki, Juha Räsänen, Merja Kokki
No abstract text is available yet for this article.
May 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29656292/c-reactive-protein-and-procalcitonin-in-case-reports-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome
#20
Simona T Hübner, Raffaela Bertoli, Alexandra E Rätz Bravo, Martina Schaueblin, Manuel Haschke, Kathrin Scherer, Alessandro Ceschi, Anne B Leuppi-Taegtmeyer
BACKGROUND: The spectrum of inflammatory marker response in DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome has not been systematically characterized. METHODS: An epidemiological biomarker study of C-reactive protein (CRP) and procalcitonin (PCT) values in patients with DRESS syndrome reported at 2 regional pharmacovigilance centers in Switzerland or published in the medical literature 2008-2016 was performed. RESULTS: Ninety-four DRESS cases were studied...
April 13, 2018: International Archives of Allergy and Immunology
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