keyword
https://read.qxmd.com/read/38536779/risk-factors-for-catheter-associated-bloodstream-infection-in-hemodialysis-patients-a-meta-analysis
#1
JOURNAL ARTICLE
Huajie Guo, Ling Zhang, Hua He, Lili Wang
OBJECTIVE: This meta-analysis aimed to elucidate the risk factors contributing to catheter-associated bloodstream infection in hemodialysis patients. METHODS: Comprehensive literature searches were conducted in both English and Chinese databases, which encompassed PubMed, Cochrane Library, Embase, CNKI, Wanfang Data, VIP Database and China Biomedical Literature Database. The search timeframe extended from each database's inception to March 8, 2023. Two independent researchers executed literature screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale...
2024: PloS One
https://read.qxmd.com/read/38536775/inflammatory-biomarker-based-clinical-practice-in-patients-with-pneumonia-a-systematic-review-of-randomized-controlled-trials
#2
JOURNAL ARTICLE
Dimitrios Dimitropoulos, Michalis Karmpadakis, Themistoklis Paraskevas, Christos Michailides, Maria Lagadinou, Christina Platanaki, Charalampos Pierrakos, Dimitrios Velissaris
UNLABELLED: Objectives: Biomarker-based clinical practice is currently gaining ground and increasingly affects decision making. A variety of biomarkers have been studied through the years and some of them have already an established role in modern medicine, such as procalcitonin (PCT) which has been proposed to reduce antibiotic exposure. We purposed to systematically review all biomarkers examined for guiding the clinical practice in patients with pneumonia. METHODS: A systematic review on PubMed was performed on April 2023 by two independent researchers using the PRISMA guidelines...
March 27, 2024: Romanian Journal of Internal Medicine
https://read.qxmd.com/read/38536706/prognostic-value-of-pretreatment-procalcitonin-and-neutrophil-lymphocyte-ratio-in-extensive-stage-small-cell-lung-cancer
#3
JOURNAL ARTICLE
Dongfang Chen, Jianlin Xu, Yizhuo Zhao, Baohui Han, Runbo Zhong
BACKGROUND: To investigate the influence of pretreatment neutrophil-to-lymphocyte ratio (NLR) and procalcitonin (PCT) on progression-free survival (PFS) in extensive-stage small-cell lung cancer (SCLC) patients. METHOD: A total of 100 extensive-stage SCLC patients were enrolled in our study. Patients were stratified according to the median values of pretreatment NLR and PCT levels: low NLR group (NLR ≤3.17), high NLR group (NLR>3.17), low PCT group (PCT ≤0...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38535886/stop-in-time-how-to-reduce-unnecessary-antibiotics-in-newborns-with-late-onset-sepsis-in-neonatal-intensive-care
#4
REVIEW
Domenico Umberto De Rose, Maria Paola Ronchetti, Alessandra Santisi, Paola Bernaschi, Ludovica Martini, Ottavia Porzio, Andrea Dotta, Cinzia Auriti
The fear of missing sepsis episodes in neonates frequently leads to indiscriminate use of antibiotics, and prescription program optimization is suggested for reducing this inappropriate usage. While different authors have studied how to reduce antibiotic overprescription in the case of early onset sepsis episodes, with different approaches being available, less is known about late-onset sepsis episodes. Biomarkers (such as C-reactive protein, procalcitonin, interleukin-6 and 8, and presepsin) can play a crucial role in the prompt diagnosis of late-onset sepsis, but their role in antimicrobial stewardship should be further studied, given that different factors can influence their levels and newborns can be subjected to prolonged therapy if their levels are expected to return to zero...
March 19, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535062/the-role-of-sars-cov-2-nucleocapsidic-antigen-and-krebs-von-den-lungen-6-serum-levels-in-predicting-covid-19-pneumonia-outcome
#5
JOURNAL ARTICLE
Stefano Sanduzzi Zamparelli, Vincenzo Fucci, Gaetano Rea, Francesco Perna, Marialuisa Bocchino, Alessandro Sanduzzi Zamparelli
BACKGROUND: The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a significant threat worldwide, with severe cases leading to hospitalization and death. This study aims to evaluate the potential use of serum nucleocapsid antigen (NAg) and Krebs von den Lungen-6 glycoprotein (KL-6) as biomarkers of severe COVID-19 and to investigate their correlation with clinical, radiological, and biochemical parameters. METHODS: This retrospective study included 128 patients with confirmed SARS-CoV-2 infection admitted to a Neapolitan hospital in Italy between October 2020 and July 2021...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38533387/talaromycosis-from-wuhan-two-case-report-and-literature-review
#6
Zhiyuan Yao, Zhou Pan, Guang Li, Zhaomin Liao, Zhen Yu, Liying Zhan, Wenfang Xia
BACKGROUND: Talaromycosis is a serious opportunistic infectious disease caused by Talaromyces marneffei , which mostly occurs in immunocompromised patients. The disease is mainly prevalent in tropical countries and regions of Southeast Asia and South Asia, but non-endemic areas also have patients with Talaromycosis. The disease has no characteristic clinical manifestations and is difficult to diagnose. Delayed diagnosis often leads to death. CASE PRESENTATION: Both patients had cellular immunodeficiency...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38532376/efficacy-of-respiratory-rehabilitation-in-patients-with-covid-19-a-retrospective-study
#7
JOURNAL ARTICLE
Zhiyou Zhang, Congcong Wang, Zhendong Li, Yueyang Liu, Yutong Nie, Jianwei Zhang, Dawei Li
OBJECTIVE: The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of confirmed cases and deaths globally. The purpose of this study was to investigate the therapeutic effect of airway clearance technology combined with prone ventilation on patients infected with COVID-19. METHODS: 38 patients with COVID-19 (severe) who were treated in the intensive rehabilitation group of Shengli Oilfield Central Hospital. They were randomly divided into a control group and an observation group...
March 26, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38532280/procalcitonin-and-c-reactive-protein-as-early-markers-of-anastomotic-leakage-in-intestinal-resections-for-advanced-ovarian-cancer-edmocs
#8
JOURNAL ARTICLE
José Luis Sánchez-Iglesias, Clara Morales-Coma, Lucas Minig, Víctor Lago, Santiago Domingo, Gemma Mancebo, Jaime Siegrist, María Soledad Fidalgo García, Antoni Llueca, Anna Serra, Paloma Cobas Lozano, Arantza Lekuona Artola, Natalia R Gómez-Hidalgo, Úrsula Acosta, Roser Ferrer-Costa, Melissa Bradbury, Assumpció Pérez-Benavente, Antonio Gil-Moreno
INTRODUCTION: Serum levels of procalcitonin and C-reactive protein (CRP) have been used to predict anastomotic leakage after colorectal surgery, but information is scarce in advanced ovarian cancer (AOC) surgery with bowel resection. This study aimed to assess the predictive value of procalcitonin and CRP in detecting anastomotic leakage after AOC surgery with bowel resection. The study also aimed to determine the optimal postoperative reference values and the best day for evaluating these markers...
March 26, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38529068/the-role-of-aggf1-in-the-classification-and-evaluating-prognosis-of-adult-septic-patients-an-observational-study
#9
JOURNAL ARTICLE
Wenqing Ji, Tiantian Wan, Fang Zhang, Shubin Guo, Xue Mei
PURPOSE: Angiogenic factor with G patch and FHA domains 1 (AGGF1) is a crucial angiogenic factor that is involved in a variety of diseases and in the regulation of inflammatory responses. However, its role in sepsis is poorly understood. We have investigated the role of AGGF1 in the classification and prognostic evaluation of adult septic patients in a clinical context. PATIENTS AND METHODS: A total of 126 septic patients who visited the Emergency Department of Beijing Chao-Yang Hospital and 76 non-sepsis patients visiting the Physical Examination Center of Beijing Chao-Yang Hospital were enrolled...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38528351/diagnostic-and-prognostic-value-of-pentraxin-3-interleukin-6-crp-and-procalcitonin-levels-in-patients-with-sepsis-and-septic-shock
#10
JOURNAL ARTICLE
B Palalıoğlu, S Erdoğan, G Atay, H C Tugrul, Ö F Özer
INTRODUCTION AND PURPOSE: In this prospective study, we aim to evaluate the effects of antibiotherapy on pentraxin-3 (PTX3), C-reactive protein (CRP), and interleukin-6 (IL-6) levels in patients with sepsis and septic shock. MATERIALS AND METHODS: In our study, CRP, procalcitonin, IL-6, and PTX3 levels at initial and 48 hours of the antibiotherapy of patients who were admitted to the pediatric intensive care unit (PICU) with the diagnosis of sepsis and septic shock between June 2020 and March 2021 were compared...
March 1, 2024: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38527992/the-influence-of-sepsis-on-erythrocytes-morphology-case-report-and-literature-review
#11
JOURNAL ARTICLE
Cristian Mircea Nicolescu, Silviu Daniel Moldovan
This paper highlights a clinical case of sepsis caused by soft tissue infection. Peripheral blood smear, plasma value of inflammatory biomarkers and the white blood cells count were performed. Significant morphological changes were revealed through peripheral blood smear test two days after patient admission. Patient developed septic shock after the third day in intensive care unit (ICU). Laboratory results showed major morphological changes (erythrocytes deformity, abnormal neutrophils); these were correlated with elevated plasma value of interleukin-6 and procalcitonin...
2024: Romanian Journal of Morphology and Embryology
https://read.qxmd.com/read/38527501/-a-multicenter-prospective-study-on-early-identification-of-refractory-mycoplasma-pneumoniae-pneumonia-in-children
#12
JOURNAL ARTICLE
D Xu, A L Zhang, J S Zheng, M W Ye, F Li, G C Qian, H B Shi, X H Jin, L P Huang, J G Mei, G H Mei, Z Xu, H Fu, J J Lin, H Z Ye, Y Zheng, L L Hua, M Yang, J M Tong, L L Chen, Y Y Zhang, D H Yang, Y L Zhou, H W Li, Y L Lan, Y L Xu, J Y Feng, X Chen, M Gong, Z M Chen, Y S Wang
Objective: To explore potential predictors of refractory Mycoplasma pneumoniae pneumonia (RMPP) in early stage. Methods: The prospective multicenter study was conducted in Zhejiang, China from May 1st , 2019 to January 31st , 2020. A total of 1 428 patients with fever >48 hours to <120 hours were studied. Their clinical data and oral pharyngeal swab samples were collected; Mycoplasma pneumoniae DNA in pharyngeal swab specimens was detected. Patients with positive Mycoplasma pneumoniae DNA results underwent a series of tests, including chest X-ray, complete blood count, C-reactive protein, lactate dehydrogenase (LDH), and procalcitonin...
March 25, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38526179/tuberculosis-disease-is-associated-with-elevated-plasma-ribonuclease-activity-in-antiretroviral-treatment-na%C3%A3-ve-people-with-hiv
#13
JOURNAL ARTICLE
Oskar Olsson, Rolf Søkilde, Fregenet Tesfaye, Sara Karlson, Sten Skogmar, Marianne Jansson, Per Björkman
BACKGROUND: The role of ribonucleases in tuberculosis (TB) among people with HIV (PWH) is unknown. We explored ribonuclease activity in plasma from PWH with and without TB. METHODS: Participants were identified from a cohort of treatment-naïve PWH in Ethiopia who had been classified for TB disease (HIV+/TB + or HIV+/TB-). Ribonuclease activity in plasma was investigated by quantification of synthetic spike-in RNAs using sequencing and qPCR, and by a specific ribonuclease activity assay...
March 25, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38524554/association-of-padi2-and-padi4-polymorphisms-in-covid-19-host-severity-and-non-survival
#14
JOURNAL ARTICLE
Ilse Adriana Gutiérrez-Pérez, Ivette Buendía-Roldán, Oscar Zaragoza-García, Gloria Pérez-Rubio, José Rafael Villafan-Bernal, Leslie Chávez-Galán, Isela Parra-Rojas, Rafael de Jesús Hernández-Zenteno, Ingrid Fricke-Galindo, Natividad Castro-Alarcón, Brandon Bautista-Becerril, Ramcés Falfán-Valencia, Iris Paola Guzmán-Guzmán
BACKGROUND: Enzymes of the peptidylarginine deiminase family (PADs) play a relevant role in the pathogenesis of COVID-19. However, the association of single nucleotide polymorphisms (SNPs) in their genes with COVID-19 severity and death is unknown. METHODOLOGY: We included 1045 patients who were diagnosed with COVID-19 between October 2020 and December 2021. All subjects were genotyped for PADI2 (rs1005753 and rs2235926) and PADI4 (rs11203366, rs11203367, and rs874881) SNPs by TaqMan assays and their associations with disease severity, death, and inflammatory biomarkers were evaluated...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38523173/risk-factors-for-hypoactive-delirium-in-patients-with-nontraumatic-ards-a-prospective-observational-study
#15
JOURNAL ARTICLE
Fuyan Lian, Fei Li, Xuemei Tang, Yuan Yuan
To investigate the incidence, characteristics and risk factors for hypoactive delirium in patients with nontraumatic acute respiratory distress syndrome (ARDS) and to explore the independent risk factors associated with hypoactive delirium and provide new ideas for early prediction and treatment. Hypoactive delirium is a known serious complication in ARDS patients, and currently, there are no effective early detection models or clinical prediction tools, and there is a lack of clinical treatment. This study included nontraumatic ARDS patients who stayed in the intensive care unit (ICU) for more than 24 h and were older than 18 years...
March 24, 2024: Scientific Reports
https://read.qxmd.com/read/38522793/procalcitonin-level-after-positive-fpies-ofc-predicts-short-term-tolerance
#16
JOURNAL ARTICLE
Chihiro Kunigami, Takanori Imai, Kosei Yamashita, Toshiyuki Takagi, Megumi Okawa, Aiko Honda, Yuki Okada, Mayu Maeda, Taro Kamiya
No abstract text is available yet for this article.
March 22, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38522433/the-impact-of-inflammatory-biomarkers-on-amputation-rates-in-patients-with-diabetic-foot-ulcers
#17
JOURNAL ARTICLE
Yun Xu, Ruina Geng, Xiangyu Meng, Zhipeng Feng, Xu Wang, Guanying Zhang, Liwei Bai
Diabetic Foot Ulcers (DFUs) are a major complication of diabetes, often leading to amputation. Understanding the relationship between haematological inflammatory markers and the incidence of amputation in DFU patients with infectious complications is crucial for improving management and outcomes. This retrospective study, conducted from May 2020 to October 2022, involved 109 patients with DFUs, categorised into amputation (AM) and non-amputation (NAM) groups. Patients were evaluated for various factors, including demographic data, DFU duration, and blood parameters such as haemoglobin A1c (HbA1c), haemoglobin (Hb), albumin (ALB), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), C-reactive protein (CRP), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR)...
April 2024: International Wound Journal
https://read.qxmd.com/read/38520173/-usefulness-of-the-mpb-infurg-semes-model-to-predict-bacteremia-in-the-patient-with-solid-tumor-in-the-emergency-department
#18
JOURNAL ARTICLE
M Muelas González, E Torner Marchesi, G Peláez Díaz, M Ramos Aranguez, J Cabañas Morafraile, W López Forero, R Rubio Díaz, J González Del Castillo, F J Candel, I Sanz-Muñoz
OBJECTIVE: To analyse a new risk score to predict bacteremia (MPB-INFURG-SEMES) in the patients with solid tumor attender for infection in the emergency departments (ED). METHODS: Prospective, multicenter observational cohort study of blood cultures (BC) obtained from adult patients with solid neoplasia treated in 63 EDs for infection from November 1, 2019, to March 31, 2020. The predictive ability of the model was analyzed with the area under the Receiver Operating Characteristic curve (AUC-ROC)...
March 23, 2024: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://read.qxmd.com/read/38518139/clinical-analysis-of-atorvastatin-calcium-fenofibrate-and-acipimox-in-the-treatment-of-hypertriglyceridemia-induced-acute-pancreatitis
#19
JOURNAL ARTICLE
Limin Tong, Suqiong Xu, Zhiyong Chen, Jian Gao, Qinghua Huang, Xinhua Lin, Sihua Lin, Zhiteng Lin, Yongxuan Zheng
BACKGROUND: Hypertriglyceridemia-induced acute pancreatitis (HTG-AP) is an increasingly recognized and potentially severe form of acute pancreatitis. The effective management of HTG-AP is critical due to its association with significant morbidity and mortality. HTG-AP poses a considerable burden on affected individuals and healthcare systems. It can result in persistent upper abdominal pain, nausea, vomiting, abdominal distension, fever, and in severe cases, hypotension or shock and multiple organ dysfunction...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38514734/dysphagia-in-patients-with-severe-covid-19-a-retrospective-study
#20
JOURNAL ARTICLE
Rie Asayama, Kaori Tanaka-Nishikubo, Masahiro Okada, Naoki Mukai, Suguru Annen, Hironori Matsumoto, Jun Takeba, Norio Sato, Naohito Hato
To investigate dysphagia after extubation in patients with severe coronavirus disease 2019 (COVID-19). We retrospectively examined patients with severe COVID-19 treated in our hospital between August 2021 and March 2022. Feeding outcomes were categorized into two groups-(1) total oral intake, and (2) difficulty in oral intake. To assess the feeding outcome, we used modified water-swallowing test (MWST) for all patients. However, in cases where aspiration or recurrent laryngeal nerve palsy was suspected, we conducted the fiberoptic endoscopic evaluation of swallowing after MWST...
March 21, 2024: Scientific Reports
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