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https://www.readbyqxmd.com/read/29049197/value-of-evaluating-procalcitonin-kinetics-in-diagnosis-of-infections-in-patients-undergoing-laparoscopic-radical-cystectomy
#1
Xiangli Ding, Delin Yang, Changxing Ke, Long Gong, Hui Zhan, Ruping Yan, Yan Chen, Haiyuan Li, Jiansong Wang
Postsurgery infection is a common complication after laparoscopic radical cystectomy (LRC) followed by urinary diversion. White blood cell (WBC) values and C-reactive protein (CRP) are routinely used as markers for infection, but lack of specificity and their elevation is often delayed in clinically significant events. In this study, we aimed to investigate the value of procalcitonin (PCT) kinetics in assisting early diagnosis of infection in patients undergoing LRC.The patients' medical records between May 2013 and May 2016 were reviewed retrospectively...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29046011/-biomarkers-in-diagnosis-treatment-and-prognosis-of-infectious-lung-diseases
#2
M Unnewehr, M Kolditz, W Windisch, B Schaaf
Biomarkers play an important role in the management of infectious pulmonary diseases, even though there is only limited evidence that biomarker-guided therapies are superior to clinical strategies.Well-established indications for the use of biomarkers are the guidance of the duration of antibiotic therapy in community-acquired pneumonia (CAP) by PCT, the decision against the use of antibiotics by CRP or PCT in ambulatory settings, and the evaluation of CAP treatment by CRP or PCT kinetics.In the prognostic assessment of CAP, the standard biomarkers of acute organ dysfunction should be given priority, e...
October 18, 2017: Pneumologie
https://www.readbyqxmd.com/read/28988637/-value-of-procalcitonin-for-infants-with-bronchiolitis-in-an-emergency-department
#3
M Desmarest, C Aupiais, J Le Gal, L Tourteau, J Le Coz, E de Paepe, L Titomanlio, A Faye
CONTEXT: Very few studies have evaluated the role of procalcitonin (PCT) in infants with bronchiolitis. AIMS: To describe infants who had both a diagnosis of bronchiolitis at the emergency department and a blood test including PCT, and to compare the characteristics of children according to the PCT value. METHODS: Infants admitted to the Pediatric Emergency Department between 1 January 2014 and 31 December 2014 who had a diagnosis of bronchiolitis and a blood test including PCT were included...
October 4, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28980274/neutrophil-gelatinase-associated-lipocalin-a-biomarker-for-early-diagnosis-of-urinary-tract-infections-in-infants
#4
Grażyna Krzemień, Małgorzata Pańczyk-Tomaszewska, Dominika Adamczuk, Iwona Kotuła, Urszula Demkow, Agnieszka Szmigielska
Early diagnosis of urinary tract infection (UTI) is challenging in infants due to unspecific symptoms, difficulty in urine collection and possible contamination. The aim of this study was to assesses the usefulness of serum and urine neutrophil gelatinase-associated lipocalin (sNGAL and uNGAL, respectively) in the diagnosis of febrile and non-febrile UTI in infants. This prospective observational study enrolled 66 infants with the first episode of UTI and 18 healthy controls. At the time of enrollment, sNGAL, uNGAL, urinalysis, urine culture, white blood cell count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), and serum creatinine (sCr) were assessed...
October 5, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28975967/application-value-of-procalcitonin-in-patients-with-central-nervous-system-infection
#5
X-F Zhang, X-Q Zhang, C-C Wu, H-W Wu, D Wei
OBJECTIVE: To study the application value of procalcitonin (PCT) in patients with central nervous system (CNS) infection. PATIENTS AND METHODS: A total of 66 patients, including 24 patients with suppurative meningitis, 20 patients with viral meningitis and 22 patients with tuberculous meningitis, were enrolled. 20 patients admitted to the hospital due to epilepsy or headache without infection in the same period were enrolled as the control group. PCT, high-sensitivity C-reactive protein (Hs-CRP), high-sensitivity C-reactive protein (Hs-CRP), protein quantification, chloride and glucose in serum and cerebrospinal fluid, were collected...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28962140/relationship-between-blood-lactic-acid-blood-procalcitonin-c-reactive-protein-and-neonatal-sepsis-and-corresponding-prognostic-significance-in-sick-children
#6
Yongfeng Jia, Ying Wang, Xinhua Yu
The study was conducted to evaluate the relationship between the blood lactic acid (BLA) level, serum procalcitonin (PCT), C-reactive protein (CRP) and the severity and prognosis of neonatal sepsis. A retrospective analysis was conducted on 90 children with sepsis admitted into the Intensive Care Unit (ICU) of the Hubei Institute for Nationalities Af liated Hospital hospital. Patients were divided into the non-survival group and the survival group. Severity of the 90 patients was evaluated according to Neonatal Critical Illness Score (NCIS)...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28961693/sepsis-markers-soluble-il-2-receptor-and-soluble-cd14-subtype-as-potential-biomarkers-for-complete-mucosal-healing-in-patients-with-inflammatory-bowel-disease
#7
Shuhei Hosomi, Hirokazu Yamagami, Shigehiro Itani, Tomomi Yukawa, Koji Otani, Yasuaki Nagami, Fumio Tanaka, Koichi Taira, Noriko Kamata, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara
Background and Aims: Novel noninvasive biomarkers with high diagnostic accuracy are required to assess mucosal healing, which is associated with sustained clinical remission, in inflammatory bowel disease. This study aimed to explore sepsis markers as potential biomarkers for mucosal healing. Methods: Patients with ulcerative colitis (UC) or Crohn's disease (CD) who underwent blood tests for C-reactive protein (CRP), serum procalcitonin (PCT) and soluble interleukin-2 receptor (sIL-2R), and plasma soluble CD14 subtype (sCD14-ST), within two weeks of endoscopy were retrospectively recruited and we assessed the relationship between marker levels and clinical features...
September 7, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28956241/predictive-value-of-procalcitonin-for-diagnosis-of-infections-in-patients-with-chronic-kidney-disease-a-comparison-with-traditional-inflammatory-markers-c-reactive-protein-white-blood-cell-count-and-neutrophil-percentage
#8
Yanbei Sun, Lijuan Jiang, Xiaonan Shao
PURPOSE: To investigate the predictive value of procalcitonin (PCT) in patients with stage 1-4 and stage 5 chronic kidney disease (CKD). METHODS: Five hundred and forty-one CKD inpatients were retrospectively analyzed and divided into CKD stage 1-4 (CKD1-4) and CKD stage 5 (CKD5) groups. Each group was further divided into non-infection, local infection, and sepsis subgroups. The clinical characteristics and inflammatory indexes of each subgroup including PCT, C-reactive protein (CRP), white blood cell count (WBC), and neutrophil percentage (N%) were compared, and the receiver operating characteristic curves to predict local infection and sepsis were plotted...
September 27, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28920169/diagnostic-value-of-strem-1-il-8-pct-and-crp-in-febrile-neutropenia-after-autologous-stem-cell-transplantation
#9
C S Michel, D Teschner, E M Wagner, M Theobald, Markus P Radsak
Infections and infectious complications are the major cause of morbidity and mortality in febrile neutropenic patients after autologous stem cell transplantation. Laboratory biomarkers are helpful for early identification of critically ill patients and optimal therapy management. Several studies in adult non-neutropenic patients proposed sTREM-1 as a superior biomarker for identification of septic patients as well as a predictor for survival in these patients compared with procalcitonin (PCT), C-reactive protein (CRP), or interleukin-8 (IL-8)...
September 17, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28919353/presepsin-a-new-marker-of-catheter-related-blood-stream-infections-in-pediatric-patients
#10
Sevgen Tanır Basaranoglu, Eda Karadag-Oncel, Kubra Aykac, Yasemin Ozsurekci, Ahmet Emre Aycan, Ali Bulent Cengiz, Ates Kara, Mehmet Ceyhan
BACKGROUND: Catheter related blood stream infections (CRBSI) are mostly preventable hospital-acquired conditions. We aimed to investigate the value of presepsin in detection of CRBSI in hospitalized children. METHODS: Hospitalized pediatric patients who had clinical suspicion of CRBSI were followed. Results of peripheral blood cultures and blood cultures from central venous catheters, procalcitonin (PCT), C-reactive protein (CRP), total white blood cell (WBC) counts were recorded...
September 14, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28918433/procalcitonin-and-c-reactive-protein-as-early-markers-of-postoperative-intra-abdominal-infection-in-patients-operated-on-colorectal-cancer
#11
E Domínguez-Comesaña, S M Estevez-Fernández, V López-Gómez, J Ballinas-Miranda, R Domínguez-Fernández
PURPOSE: The aim of this study was to evaluate the accuracy of serum procalcitonin (PCT) and C-reactive protein (CRP) for early diagnosis of postoperative intra-abdominal infections (PIAI) after elective surgery for colorectal cancer. METHODS: Prospective observational study including patients operated on for colorectal cancer between January and December of 2015 was performed. Serum PCT and CRP levels were measured before surgery and daily until postoperative day 3...
September 16, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28898742/neutrophil-cd64-c-reactive-protein-and-procalcitonin-in-the-identification-of-sepsis-in-the-icu-post-test-probabilities
#12
Joel Jämsä, Tero Ala-Kokko, Virva Huotari, Pasi Ohtonen, Eeva-Riitta Savolainen, Hannu Syrjälä
PURPOSE: We were interested in whether C-reactive protein (CRP) and procalcitonin (PCT) distinguish sepsis from non-septic controls and whether a combination of CRP, PCT, and neutrophil CD64 improves identification of sepsis in the intensive care unit (ICU). MATERIALS AND METHODS: We analyzed the CRP and PCT concentrations from 27 patients with sepsis and 15 ICU controls. In addition, CD64 on neutrophils was measured using quantitative flow cytometry. We present a multiple marker analysis for sepsis diagnostics combining neutrophil CD64, CRP, and PCT using post-test analysis...
August 31, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28894729/procalcitonin-for-diagnostics-and-treatment-decisions-in-pediatric-lower-respiratory-tract-infections
#13
Philipp Baumann, Gurli Baer, Jessica Bonhoeffer, Aline Fuchs, Verena Gotta, Ulrich Heininger, Nicole Ritz, Gabor Szinnai, Jan Bonhoeffer
Mortality and morbidity remain high in pediatric lower respiratory tract infections (LRTIs) despite progress in research and implementation of global diagnostic and treatment strategies in the last decade. Still, 120 million annual episodes of pneumonia affect children younger than 5 years each year leading to 1.3 million fatalities with the major burden of disease carried by low- and middle-income countries (95%). The definition of pneumonia is still challenging. Traditional diagnostic measures (i.e., chest radiographs, C-reactive protein) are unable to distinguish viral and from bacterial etiology...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28885233/diagnostic-value-of-pct-and-crp-for-detecting-serious-bacterial-infections-in-patients-with-fever-of-unknown-origin-a-systematic-review-and-meta-analysis
#14
Lan Hu, Qiuping Shi, Miao Shi, Ruixia Liu, Chao Wang
BACKGROUND: It is vital to recognize the cause of an infection to enable earlier treatment. Studies have shown that procalcitonin (PCT) and C-reactive protein (CRP) have very high sensitivity and specificity for diagnosing serious bacterial infections (SBIs), with PCT performing better than CRP. METHODS: Multiple databases were searched for relevant studies, and full-text articles involving diagnosis with PCT and CRP were reviewed. All meta-analyses were conducted with Review Manager 5...
September 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28876695/the-role-of-procalcitonin-as-a-diagnostic-marker-of-bacterial-sepsis-in-burns
#15
D L Wineberg, D Kruger
BACKGROUND: Patients with burn wounds are at high risk of infection. Since sepsis contributes significantly to morbidity and mortality, early diagnosis is essential. Procalcitonin (PCT) is a biomarker released in response to inflammation and specifically bacterial infection. It may therefore be a useful biomarker for sepsis in burns. METHOD: All adult patients admitted to two Burns Intensive Care Units in Johannesburg were included in a retrospective data review...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28876643/the-role-of-il17-a-in-the-second-hit-of-acute-pancreatitis
#16
J T Thomson, M B Brand, P FruFonteh
BACKGROUND: Acute pancreatitis is characterised by distinct clinical phases. An initial systemic inflammation response syndrome (SIRS) and occasional subsequent 'second hit' usually initiated by systemic sepsis. The pro-inflammatory T-helper 17 pathway has been shown to be an initiator of early SIRS in AP; however, to date, interleukin-17A has not been evaluated as a marker of the septic second hit in severe acute pancreatitis (SAP). METHOD: Twenty-five (aged 22-78) with mild (n = 12), moderate (n = 5) and severe (n = 8) acute pancreatitis were enrolled...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28875483/comparison-of-diagnostic-accuracy-in-sepsis-between-presepsin-procalcitonin-and-c-reactive-protein-a-systematic-review-and-meta-analysis
#17
Chin-Chieh Wu, Hao-Min Lan, Shih-Tsung Han, Chung-Hsien Chaou, Chun-Fu Yeh, Su-Hsun Liu, Chih-Huang Li, Gerald N Blaney, Zhen-Ying Liu, Kuan-Fu Chen
BACKGROUND: The soluble cluster of differentiation 14 (or presepsin) is a free fragment of glycoprotein expressed on monocytes and macrophages. Although many studies have been conducted recently, the diagnostic performance of presepsin for sepsis remains debated. We performed a systematic review and meta-analysis of the available literature to assess the accuracy of presepsin for the diagnosis of sepsis in adult patients and compared the performance between presepsin, C-reactive protein (CRP), and procalcitonin (PCT)...
September 6, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28866970/calprotectin-as-an-early-biomarker-of-bacterial-infections-in-critically-ill-patients-an-exploratory-cohort-assessment
#18
Niklas Jonsson, Tom Nilsen, Patrik Gille-Johnson, Max Bell, Claes-Roland Martling, Anders Larsson, Johan Mårtensson
BACKGROUND: Calprotectin is the most abundant protein in the cytosolic fraction of neutrophils, and neutrophil degranulation is a major response to bacterial infections. OBJECTIVES: To assess the value of plasma calprotectin as an early marker of bacterial infections in critically ill patients and compare it with the corresponding values for procalcitonin (PCT), C-reactive protein (CRP) and white blood cell count (WBC). METHODS: We measured daily plasma calprotectin levels in 110 intensive care unit patients using a newly developed turbidimetric assay run on clinical chemistry analysers...
September 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/28858084/diagnostic-value-of-lactate-procalcitonin-ferritin-serum-c-reactive-protein-and-other-biomarkers-in-bacterial-and-viral-meningitis-a-cross-sectional-study
#19
Anahita Sanaei Dashti, Shekoofan Alizadeh, Abdullah Karimi, Masoomeh Khalifeh, Seyed Abdolmajid Shoja
There are many difficulties distinguishing bacterial from viral meningitis that could be reasonably solved using biomarkers. The aim of this study was to evaluate lactate, procalcitonin (PCT), ferritin, serum-CRP (C-reactive protein), and other known biomarkers in differentiating bacterial meningitis from viral meningitis in children.All children aged 28 days to 14 years with suspected meningitis who were admitted to Mofid Children's Hospital, Tehran, between October 2012 and November 2013, were enrolled in this prospective cross-sectional study...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28851286/influence-of-the-postoperative-inflammatory-response-on-cognitive-decline-in-elderly-patients-undergoing-on-pump-cardiac-surgery-a-controlled-prospective-observational-study
#20
Endre Nemeth, Katalin Vig, Kristof Racz, Kinga B Koritsanszky, Klara I Ronkay, Fumiko P Hamvas, Csaba Borbély, Ajandek Eory, Bela Merkely, Janos Gal
BACKGROUND: The role of non-infective inflammatory response (IR) in the aetiology of postoperative cognitive dysfunction (POCD) is still controversial. The aim of this controlled, prospective observational study was to assess the possible relationship between the grade of IR, defined by procalcitonin (PCT) changes, and development of POCD related to cardiac surgery. METHODS: Forty-two patients, who were ≥ 60 years of age and scheduled for elective cardiac surgery, were separated into the low inflammatory (LIR) and high inflammatory (HIR) response groups based on their PCT levels measured on the first postoperative day...
August 29, 2017: BMC Anesthesiology
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