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https://www.readbyqxmd.com/read/29656292/c-reactive-protein-and-procalcitonin-in-case-reports-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome
#1
Simona T Hübner, Raffaela Bertoli, Alexandra E Rätz Bravo, Martina Schaueblin, Manuel Haschke, Kathrin Scherer, Alessandro Ceschi, Anne B Leuppi-Taegtmeyer
BACKGROUND: The spectrum of inflammatory marker response in DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome has not been systematically characterized. METHODS: An epidemiological biomarker study of C-reactive protein (CRP) and procalcitonin (PCT) values in patients with DRESS syndrome reported at 2 regional pharmacovigilance centers in Switzerland or published in the medical literature 2008-2016 was performed. RESULTS: Ninety-four DRESS cases were studied...
April 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29648996/serum-procalcitonin-concentration-within-2-days-postoperatively-accurately-predicts-outcome-after-liver-resection
#2
Yuto Aoki, Nobuhiko Taniai, Masato Yoshioka, Youichi Kawano, Tetsuya Shimizu, Tomohiro Kanda, Ryota Kondo, Yohei Kaneya, Hiroyasu Furuki, Eiji Uchida
BACKGROUND: Relatively high mortality and morbidity rates are reported after liver resection (LR). However, the early predictors of complications after LR are not clear. This study was performed to clarify the usefulness of procalcitonin (PCT) for the early prediction of complications after elective LR. METHODS: This observational study included 72 consecutive patients who underwent elective LR from December 2015 to March 2017. Patients were categorized into two groups: those with and without postoperative complications (Clavien-Dindo grade ≥II)...
April 12, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29624484/early-inflammatory-biomarkers-as-predictive-factors-for-freedom-from-infection-after-colorectal-cancer-surgery-a-prospective-cohort-study
#3
André Goulart, Carla Ferreira, Alexandra Estrada, Fernanda Nogueira, Sandra Martins, António Mesquita-Rodrigues, Nuno Sousa, Pedro Leão
PURPOSE: Different biomarkers are useful in diagnosing infections. The aim of this work was to clarify the relation between different inflammatory biomarkers (white blood cell [WBC] count, C-reactive protein [CRP], procalcitonin [PCT], and C-reactive protein-to-albumin ratio [CAR]) and early infectious complications after colorectal surgery. METHODS: This prospective single-center cohort study included 130 patients undergoing elective colorectal surgery. The WBC count, CRP, and PCT were measured at post-operative day one (POD1) and POD3 and albumin on POD3...
April 6, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29619901/inflammatory-biomarkers-to-guide-diagnostic-and-therapeutic-decisions-in-children-presenting-with-fever-without-apparent-source
#4
Giulia Trippella, Luisa Galli, Maurizio de Martino, Elena Chiappini
A systematic review of literature from 2011 to 2016 was performed, in order to evaluate the diagnostic performance of inflammatory biomarkers in children with fever without apparent source and their usefulness in clinical decision-making. Data source was the Pubmed database. Thirteen studies were included, analysing the following biomarkers: erythrocyte sedimentation rate, white blood count, absolute neutrophil count, C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6) and the Lab-score (a combination of CRP, PCT and urine dipstick)...
April 5, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29616457/presepsin-as-a-diagnostic-marker-of-bacterial-infections-in-febrile-neutropenic-pediatric-patients-with-hematological-malignancies
#5
Ahmad Baraka, Marwa Zakaria
Febrile neutropenia (FN) is often observed in hematological malignancies (HEM). Presepsin is also known as soluble CD14 subtype; it is a glycoprotein fragment derived from monocytes and macrophages. We aimed to evaluate the significance of presepsin and other biomarkers for diagnosis of bacteremia in children with HEM. Sixty pediatric patients with different HEM (acute lymphoblastic leukemia 36, acute myeloid leukemia 12, non-Hodgkin lymphoma 10, and Hodgkin disease 2). Thirty age and sex-matched healthy children serving as control were enrolled in this study...
April 3, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29610604/correlation-of-procalcitonin-and-c-reactive-protein-with-intra-abdominal-hypertension-in-intra-abdominal-infections-their-predictive-role-in-the-progress-of-the-disease
#6
Bedri Braha, Dafina Mahmutaj, Mehmet Maxhuni, Burim Neziri, Shaip Krasniqi
AIM: To analyse the correlation of procalcitonin (PCT) and C-reactive protein (CRP) values with increased intra-abdominal pressure and to evaluate their predictive role in the progression of Intra-abdominal infections. MATERIALS AND METHODS: A non-randomized prospective study conducted in the group of 80 patients. We have measured the PCT, CRP and intra-abdominal pressure (IAP). RESULTS: According to IAH grades (G), there was a significant difference of PCT values: G I 3...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29593801/inflammatory-mediators-in-the-diagnosis-and-treatment-of-acute-pancreatitis-pentraxin-3-procalcitonin-and-myeloperoxidase
#7
Osman Simsek, Ahmet Kocael, Pınar Kocael, Anıl Orhan, Mahir Cengiz, Huriye Balcı, Kenan Ulualp, Hafize Uzun
Introduction: Acute pancreatitis (AP) is the third most common gastrointestinal disease at hospital admission. The etiology and pathogenesis of this disease are not completely clear. Our study was intended to determine the systemic levels of pentraxin-3 (PTX-3), myeloperoxidase (MPO), procalcitonin (PCT), and C-reactive protein (CRP) as prognostic parameters in early stages of AP. We also determined the effects of treatment on PTX-3, MPO, PCT and CRP levels in AP. Material and methods: The study group comprised 44 AP patients (22 male, 22 female; age: 49...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29577181/a-comparative-evaluation-of-presepsin-with-procalcitonin-and-crp-in-diagnosing-neonatal-sepsis
#8
Neeraj Kumar, Rajeshwar Dayal, Pratibha Singh, Sunit Pathak, Vishal Pooniya, Ankur Goyal, Raj Kamal, K K Mohanty
The objectives of this study were to study the clinical and biochemical profile of neonates with sepsis and to evaluate the diagnostic role of presepsin and its comparison with C-reactive protein (CRP) and Procalcitonin (PCT). This study was conducted from March 2015 through October 2016 in Neonatal intensive care unit (NICU) at S N Medical College, Agra. Neonates with ≥1 clinical features of sepsis and/or two risk factors were included. A total of 41 cases and 41 controls were taken. Blood sample was taken for all investigations...
March 26, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29571718/c-reactive-protein-response-patterns-after-antibiotic-treatment-among-children-with-scalds
#9
Ingrid Steinvall, Matilda Karlsson, Moustafa Elmasry
BACKGROUND: Scalds are the most common cause of burns in children, yet there is little information available about the inflammatory response. The aim of the study was to investigate the response to treatment with antibiotics among scalded children by following the C-reactive protein (CRP) concentration, procalcitonin (PCT) concentration, and white blood cell count (WCC) during the first two weeks after injury. METHODS: All children with scalds who presented to the Burn Centre during 2010-2016 were included in this retrospective study...
March 20, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29567889/evaluation-of-procalcitonin-as-a-diagnostic-marker-in-neonatal-sepsis
#10
Marie Victor Pravin Charles, Ramakrishnan Kalaivani, Soma Venkatesh, Arunava Kali, Kunigal Srinivasiah Seetha
Context: Neonatal sepsis is an early infection occurring within 28 days of the postnatal life. It has nonspecific signs and symptoms which make the diagnosis cumbersome. It inflicts an increase in morbidity and mortality among neonates. Procalcitonin (PCT) is yet another acute phase reactant, which is synthesized by the C-cells of thyroid gland. Aims: The aim of our study is to evaluate PCT as a diagnostic marker of neonatal sepsis in comparison with C-reactive protein (CRP)...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29563816/the-diagnostic-utility-of-procalcitonin-interleukin-6-and-interleukin-8-and-hyaluronic-acid-in-the-norwegian-consensus-definition-for-early-onset-neonatal-sepsis-eons
#11
Britt Nakstad
Introduction: A key challenge in identifying serious bacterial infection in new born infants is the nonspecific clinical presentation of early-onset neonatal sepsis (EONS). Routinely used C-reactive protein, white blood cell count, and platelets are nonspecific. We assessed the diagnostic utility of single biomarkers or combinations of procalcitonin (PCT), interleukin (IL)-6, IL-8, and hyaluronic acid (HA) in newborn infant with EONS, and in human umbilical cord blood (HUCB) from deliveries with chorioamnionitis...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29562917/the-use-of-mid-regional-proadrenomedullin-to-identify-disease-severity-and-treatment-response-to-sepsis-a-secondary-analysis-of-a-large-randomised-controlled-trial
#12
Gunnar Elke, Frank Bloos, Darius Cameron Wilson, Frank Martin Brunkhorst, Josef Briegel, Konrad Reinhart, Markus Loeffler, Stefan Kluge, Axel Nierhaus, Ulrich Jaschinski, Onnen Moerer, Andreas Weyland, Patrick Meybohm
BACKGROUND: This study assessed the ability of mid-regional proadrenomedullin (MR-proADM) in comparison to conventional biomarkers (procalcitonin (PCT), lactate, C-reactive protein) and clinical scores to identify disease severity in patients with sepsis. METHODS: This is a secondary analysis of a randomised controlled trial in patients with severe sepsis or septic shock across 33 German intensive care units. The association between biomarkers and clinical scores with mortality was assessed by Cox regression analysis, area under the receiver operating characteristic and Kaplan-Meier curves...
March 21, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29555393/cytokine-kinetic-profiles-in-children-with-acute-lower-respiratory-tract-infection-a-post-hoc-descriptive-analysis-from-a-randomized-control-trial
#13
Aline Fuchs, Verena Gotta, Marie-Luise, Gabor Szinnai, Philipp Baumann, Jan Bonhoeffer, Nicole Ritz
OBJECTIVE: Standard inflammatory markers and chest radiography lack the ability to discriminate bacterial from non-bacterial lower respiratory tract infection (LRTI). Cytokine profiles may serve as biomarkers for LRTI, but their applicability to identify aetiology, severity of disease and need for antibiotic prescription in children remains poorly defined. Objectives were to determine the cytokine kinetic profiles over five days in paediatric patients with LRTI, to investigate the relationship between cytokine patterns, and clinical and laboratory variables...
March 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29541387/dcr3-a-new-biomarker-for-sepsis-correlates-with-infection-severity-and-procalcitonin
#14
Liqin Gao, Bin Yang, Hairong Zhang, Qishui Ou, Yulan Lin, Mei Zhang, Zhenhuan Zhang, Sunghee Kim, Bing Wu, Zeng Wang, Lengxi Fu, Jingan Lin, Ruiqing Chen, Ruilong Lan, Junying Chen, Wei Chen, Long Chen, Hengshan Zhang, Deping Han, Jingrong Chen, Paul Okunieff, Jianhua Lin, Lurong Zhang
Early diagnosis of sepsis is critical for successful treatment. The clinical value of DcR3 in early diagnosis of sepsis was determined in a dynamic follow-up study. Alterations in plasma levels of DcR3, PCT, CRP, and IL-6 were measured by ELISA and compared among patients with sepsis ( n = 134), SIRS ( n = 60) and normal adults ( n = 50). Correlations and dynamic patterns among the biomarkers, APACHE II scores, clinical outcomes, and pathogens were also examined. Plasma DcR3 was significantly increased in sepsis compared to SIRS and normal adults (median 3...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29531448/relationship-of-serum-procalcitonin-c-reactive-protein-and-lactic-acid-to-organ-failure-and-outcome-in-critically-ill-pediatric-population
#15
Imran Siddiqui, Lena Jafri, Qalab Abbas, Ahmed Raheem, Anwar Ul Haque
Objective: To evaluate the clinical and prognostic utility of procalcitonin (PCT), C-reactive protein (CRP), and lactic acid in children admitted to the Pediatric Intensive Care Unit (PICU) of a university teaching hospital. Materials and Methods: Medical records of children (1 month-16 years) tested for serum PCT at the time of admission in the PICU of our hospital from July 1, 2013, to January 15, 2015, were reviewed. Within 24 h of admission, the Pediatric Risk of Mortality Score, blood cultures, white blood cell count, neutrophil counts, serum CRP, plasma lactic acid, and PCT were noted...
February 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29528854/the-role-of-procalcitonin-in-the-management-of-pleural-infection
#16
Duneesha de Fonseka, Nick A Maskell
PURPOSE OF REVIEW: Pleural infection is a common problem associated with significant morbidity and mortality. Systemic or pleural fluid markers for reliably identifying pleural infection are limited. Procalcitonin (PCT) is known to be elevated in bacterial infection and is currently used for diagnosis and decision-making regarding antibiotic duration in respiratory infections. This review investigates if there is a role for serum and pleural fluid PCT (pf-PCT) in diagnosis and management of pleural infection...
March 9, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29520440/procalcitonin-and-c-reactive-protein-as-early-markers-of-anastomotic-leak-after-laparoscopic-colorectal-surgery-within-an-enhanced-recovery-after-surgery-eras-program
#17
José Luis Muñoz, María Oliva Alvarez, Vicent Cuquerella, Elena Miranda, Carlos Picó, Raquel Flores, Marta Resalt-Pereira, Pedro Moya, Ana Pérez, Antonio Arroyo
BACKGROUND: C-reactive protein (CRP) and procalcitonin (PCT) have been described as good predictors of anastomotic leak after colorectal surgery, obtaining the highest diagnostic accuracy on the 5th postoperative day. However, if an enhanced recovery after surgery (ERAS) program is performed, early predictors are needed in order to ensure a safe and early discharge. The aim of this study was to investigate the efficacy of CRP, PCT, and white blood cell (WBC) count determined on first postoperative days, in predicting septic complications, especially anastomotic leak, after laparoscopic colorectal surgery performed within an ERAS program...
March 8, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29519283/-effect-of-lateral-position-ventilation-combined-with-vibration-sputum-drainage-on-patients-with-acute-respiratory-distress-syndrome-a-prospective-randomized-controlled-trial
#18
Lingchen Kong, Jianzhong Li, Peng Wu, Jianhua Xu, Honglei Li, Haifei Long, Pan Liu, Fangfang Wei, Wenhong Peng
OBJECTIVE: To investigate the curative effect of lateral position ventilation combined with vibration sputum drainage on the patients with acute respiratory distress syndrome (ARDS). METHODS: A prospective randomized controlled trial was conducted. The patients with ARDS undergoing mechanical ventilation (MV) admitted to intensive care unit (ICU) of Linyi Central Hospital from January 2013 to June 2017 were enrolled, and they were divided into simple ventilation group and combined treatment group according to random number table...
March 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29516256/utility-of-c-reactive-protein-as-predictive-biomarker-of-anastomotic-leak-after-minimally-invasive-esophagectomy
#19
Emanuele Asti, Gianluca Bonitta, Matteo Melloni, Stefania Tornese, Pamela Milito, Andrea Sironi, Elena Costa, Luigi Bonavina
BACKGROUND: Early detection of anastomotic leakage after esophagectomy has the potential to reduce morbidity and mortality. Prompt suspicion of leak may help to exclude patients from fast-track protocols, thereby avoiding early oral feeding and early hospital discharge which could aggravate the prognosis of a clinically occult leak. PATIENTS AND METHODS: Observational retrospective cohort study. Patients with diagnosis of esophageal cancer who underwent elective minimally invasive esophagectomy were included...
March 7, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29514604/efficacy-of-serum-procalcitonin-to-predict-spontaneous-preterm-birth-in-women-with-threatened-preterm-labour-a-prospective-observational-study
#20
Guillaume Ducarme, François Desroys du Roure, Aurélie Le Thuaut, Joséphine Grange, Mathilde Vital, Jérôme Dimet
BACKGROUND: A hypothesis of preterm parturition is that the pathogenesis of spontaneous preterm birth (sPTB) may be associated with an inflammatory process. Based on this theory, we have hypothesized that an inflammatory biomarker, procalcitonin (PCT), may be a good predictive marker of sPTB at the admission for threatened preterm labour (TPL). The present study was aimed to investigate the association between serum PCT and sPTB in women with TPL and to evaluate whether PCT levels may predict sPTB in women with TPL within 7 or 14 days...
March 7, 2018: BMC Pregnancy and Childbirth
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