keyword
https://read.qxmd.com/read/38536779/risk-factors-for-catheter-associated-bloodstream-infection-in-hemodialysis-patients-a-meta-analysis
#1
JOURNAL ARTICLE
Huajie Guo, Ling Zhang, Hua He, Lili Wang
OBJECTIVE: This meta-analysis aimed to elucidate the risk factors contributing to catheter-associated bloodstream infection in hemodialysis patients. METHODS: Comprehensive literature searches were conducted in both English and Chinese databases, which encompassed PubMed, Cochrane Library, Embase, CNKI, Wanfang Data, VIP Database and China Biomedical Literature Database. The search timeframe extended from each database's inception to March 8, 2023. Two independent researchers executed literature screening, data extraction, and quality assessment using the Newcastle-Ottawa Scale...
2024: PloS One
https://read.qxmd.com/read/38536775/inflammatory-biomarker-based-clinical-practice-in-patients-with-pneumonia-a-systematic-review-of-randomized-controlled-trials
#2
JOURNAL ARTICLE
Dimitrios Dimitropoulos, Michalis Karmpadakis, Themistoklis Paraskevas, Christos Michailides, Maria Lagadinou, Christina Platanaki, Charalampos Pierrakos, Dimitrios Velissaris
UNLABELLED: Objectives: Biomarker-based clinical practice is currently gaining ground and increasingly affects decision making. A variety of biomarkers have been studied through the years and some of them have already an established role in modern medicine, such as procalcitonin (PCT) which has been proposed to reduce antibiotic exposure. We purposed to systematically review all biomarkers examined for guiding the clinical practice in patients with pneumonia. METHODS: A systematic review on PubMed was performed on April 2023 by two independent researchers using the PRISMA guidelines...
March 27, 2024: Romanian Journal of Internal Medicine
https://read.qxmd.com/read/38535062/the-role-of-sars-cov-2-nucleocapsidic-antigen-and-krebs-von-den-lungen-6-serum-levels-in-predicting-covid-19-pneumonia-outcome
#3
JOURNAL ARTICLE
Stefano Sanduzzi Zamparelli, Vincenzo Fucci, Gaetano Rea, Francesco Perna, Marialuisa Bocchino, Alessandro Sanduzzi Zamparelli
BACKGROUND: The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a significant threat worldwide, with severe cases leading to hospitalization and death. This study aims to evaluate the potential use of serum nucleocapsid antigen (NAg) and Krebs von den Lungen-6 glycoprotein (KL-6) as biomarkers of severe COVID-19 and to investigate their correlation with clinical, radiological, and biochemical parameters. METHODS: This retrospective study included 128 patients with confirmed SARS-CoV-2 infection admitted to a Neapolitan hospital in Italy between October 2020 and July 2021...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38528351/diagnostic-and-prognostic-value-of-pentraxin-3-interleukin-6-crp-and-procalcitonin-levels-in-patients-with-sepsis-and-septic-shock
#4
JOURNAL ARTICLE
B Palalıoğlu, S Erdoğan, G Atay, H C Tugrul, Ö F Özer
INTRODUCTION AND PURPOSE: In this prospective study, we aim to evaluate the effects of antibiotherapy on pentraxin-3 (PTX3), C-reactive protein (CRP), and interleukin-6 (IL-6) levels in patients with sepsis and septic shock. MATERIALS AND METHODS: In our study, CRP, procalcitonin, IL-6, and PTX3 levels at initial and 48 hours of the antibiotherapy of patients who were admitted to the pediatric intensive care unit (PICU) with the diagnosis of sepsis and septic shock between June 2020 and March 2021 were compared...
March 1, 2024: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38522433/the-impact-of-inflammatory-biomarkers-on-amputation-rates-in-patients-with-diabetic-foot-ulcers
#5
JOURNAL ARTICLE
Yun Xu, Ruina Geng, Xiangyu Meng, Zhipeng Feng, Xu Wang, Guanying Zhang, Liwei Bai
Diabetic Foot Ulcers (DFUs) are a major complication of diabetes, often leading to amputation. Understanding the relationship between haematological inflammatory markers and the incidence of amputation in DFU patients with infectious complications is crucial for improving management and outcomes. This retrospective study, conducted from May 2020 to October 2022, involved 109 patients with DFUs, categorised into amputation (AM) and non-amputation (NAM) groups. Patients were evaluated for various factors, including demographic data, DFU duration, and blood parameters such as haemoglobin A1c (HbA1c), haemoglobin (Hb), albumin (ALB), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), procalcitonin (PCT), C-reactive protein (CRP), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR)...
April 2024: International Wound Journal
https://read.qxmd.com/read/38514734/dysphagia-in-patients-with-severe-covid-19-a-retrospective-study
#6
JOURNAL ARTICLE
Rie Asayama, Kaori Tanaka-Nishikubo, Masahiro Okada, Naoki Mukai, Suguru Annen, Hironori Matsumoto, Jun Takeba, Norio Sato, Naohito Hato
To investigate dysphagia after extubation in patients with severe coronavirus disease 2019 (COVID-19). We retrospectively examined patients with severe COVID-19 treated in our hospital between August 2021 and March 2022. Feeding outcomes were categorized into two groups-(1) total oral intake, and (2) difficulty in oral intake. To assess the feeding outcome, we used modified water-swallowing test (MWST) for all patients. However, in cases where aspiration or recurrent laryngeal nerve palsy was suspected, we conducted the fiberoptic endoscopic evaluation of swallowing after MWST...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38509994/fibroblast-growth-factor-23-during-septic-shock-and-myocardial-injury-in-icu-patients
#7
JOURNAL ARTICLE
Zheng Yang, Jie Wang, Jilin Ma, Danhong Ren, Zhihui Li, Kun Fang, Zhanli Shi
OBJECTIVE: Fibroblast growth factor 23 (FGF23) has been recognized as an important biomarker of cardiovascular disease and is closely related to inflammation over the past decade. This study aimed to assess the relationship between FGF23 and myocardial injury in patients with sepsis. METHODS: We sequentially measured serum FGF23, Klotho, biomarkers of inflammation (CRP, IL-6 and WBC), myocardial injury (cTnI and N-terminal B-type natriuretic peptide) and sepsis (procalcitonin) at peak of intercurrent septic shock and after complete resolution or before death in a series of 29 patients with septic shock...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38505923/diagnostic-and-prognostic-value-of-peripheral-neutrophil-cd64-index-in-elderly-patients-with-community-acquired-pneumonia
#8
JOURNAL ARTICLE
Yan Li, Jing Zhang, Suhang Wang, Jie Cao
Community-acquired pneumonia (CAP) is a leading cause of hospitalization and mortality in the elderly. The peripheral blood neutrophil CD64 (nCD64) index is increasingly recognized for its association with poor pneumonia prognosis. A comprehensive investigation involving 128 elderly patients diagnosed with CAP, including 96 with non-severe CAP and 32 with severe CAP, from January 2020 to January 2021 was performed. The nCD64 index, CD4+, CD8+, C-reactive protein (CRP), white blood cell (WBC) count, procalcitonin (PCT), neutrophil (NEUT), and B lymphocyte count were determined using flow cytometry...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/38505247/reliability-of-droplet-digital-pcr-alone-and-in-combination-with-interleukin-6-and-procalcitonin-for-prognosis-of-bloodstream-infection
#9
JOURNAL ARTICLE
Sheng Yin, YingRui Lin, Bingqi Wang, Yizhi Peng, Zeyou Wang, Xiaolin Zhu, Hao Liang, Xianping Li, Min Wang
PURPOSE: Bloodstream infection(BSI) is linked with high mortality, underscoring the significance of prompt etiological diagnosis for timely and precise treatment. This study aims to investigate the diagnostic value of droplet digital polymerase chain reaction(ddPCR) in combination with conventional inflammatory markers [interleukin-6(IL-6) and procalcitonin(PCT)] concerning disease progression and treatment prognosis in BSI patients. Furthermore, the study aims to explore a more efficient clinical application strategy...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38505145/biomarkers-in-the-severity-of-necrotizing-enterocolitis-in-preterm-infants-a-pilot-study
#10
JOURNAL ARTICLE
Wei Meng, Qing Wang, Qingyu Xu, Hongli Gao, Yunjun Zhou, Wei Shao
BACKGROUND: The occurrence of necrotizing enterocolitis (NEC) is a common and severe disease of the digestive system in neonates. This study aims to assess the value of the intestinal tissue oxygen saturation (rint SO2 ) combined with the levels of procalcitonin (PCT) and mean platelet volume (MPV) in predicting the severity of NEC in preterm infants. METHODS: This experiment was a retrospective cohort study conducted in the Department of Pediatrics, Hongqi Hospital Affiliated to Mudanjiang Medical University between January 2017 and July 2022...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38504695/predictive-and-prognostic-potentials-of-lymphocyte-c-reactive-protein-ratio-upon-hospitalization-in-adult-patients-with-acute-pancreatitis
#11
JOURNAL ARTICLE
Xiao-Yu Xu, Yang Gao, Chuang-Shi Yue, Yu-Jia Tang, Zhao-Jin Zhang, Feng-Jie Xie, Hong Zhang, Yu-Cheng Zhu, Yan Zhang, Qi-Qi Lai, Xin-Tong Wang, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Jian-Nan Zhang, Kai Kang
PURPOSE: In this study, our objective was to investigate the potential utility of lymphocyte-C-reactive protein ratio (LCR) as a predictor of disease progression and a screening tool for intensive care unit (ICU) admission in adult patients with acute pancreatitis (AP). METHODS: We included a total of 217 adult patients with AP who were admitted to the First Affiliated Hospital of Harbin Medical University between July 2019 and June 2022. These patients were categorized into three groups: mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP), based on the presence and duration of organ dysfunction...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38504265/postoperative-hyper-inflammation-as-a-predictor-of-poor-outcomes-in-patients-with-acute-type-a-aortic-dissection-ataad-undergoing-surgical-repair
#12
JOURNAL ARTICLE
Yuan-Xi Luo, Yusanjan Matniyaz, Yu-Xian Tang, Yun-Xing Xue, Yi Jiang, Ke Pan, Zhi-Kang Lv, Zhi-Wei Fan, Kuo Wang, Hai-Tao Zhang, He Zhang, Wen-Zhe Wang, Tuo Pan, Dong-Jin Wang, Fu-Dong Fan
BACKGROUND: Postoperative hyper-inflammation is a frequent event in patients with acute Stanford type A aortic dissection (ATAAD) after surgical repair. This study's objective was to determine which inflammatory biomarkers could be used to make a better formula for identifying postoperative hyper-inflammation, and which risk factors were associated with hyper-inflammation. METHODS: A total of 405 patients were enrolled in this study from October 1, 2020 to April 1, 2023...
March 19, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38504206/interleukin-6-on-postoperative-day-three-as-an-early-predictor-of-infections-following-laparoscopic-gastric-cancer-resection
#13
JOURNAL ARTICLE
Yongzhou Huang, Lei Yang, Wenchang Yang, Pei Zhou, Qi Jiang, Weizhen Liu, Yuping Yin, Xiangyu Zeng, Peng Zhang, Kaixiong Tao
BACKGROUND: To investigate the role of C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) as early predictors of infectious complications after laparoscopic gastric cancer surgery. METHODS: Patients who underwent laparoscopic gastric cancer surgery between January 2020 and June 2022 were retrospectively enrolled. IL-6, PCT, and CRP levels were assessed before surgery and on postoperative days (PODs) 3 and 5. Differences in serum IL-6, PCT, and CRP levels between the infected and non-infected groups were compared...
March 19, 2024: BMC Surgery
https://read.qxmd.com/read/38499348/protocol-for-the-diagnostic-performance-of-c-reactive-protein-procalcitonin-and-interleukin-6-for-serious-bacterial-infections-among-children-%C3%A2-36-months-old-presenting-with-fever-without-source-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Natalia Sutiman, Sarah Hui Wen Yao, Sharon Si Min Goh, Rehena Sultana, Shu-Ling Chong
INTRODUCTION: The management of fever without source in children ≤36 months old remains a diagnostic challenge as the underlying aetiologies can vary from self-limiting viral infections to serious bacterial infections (SBIs). Biomarkers such as C reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6) have varying thresholds in the prediction of SBIs due to differences in SBI definitions, SBI prevalence, patient characteristics and timing of presentation. This protocol describes a systematic review and meta-analysis that aims to determine the thresholds at which CRP, PCT and IL-6 can perform optimally in distinguishing the presence of SBIs in children ≤36 months old, as well as to determine their performances in early detection of bacterial infections within 48 hours of fever onset...
March 18, 2024: BMJ Paediatrics Open
https://read.qxmd.com/read/38499000/detection-and-analysis-of-commonly-used-infection-indicators-in-patients-with-acute-urticaria
#15
JOURNAL ARTICLE
Jia Deng, Jifeng Liu, Wenzhong Xiang
INTRODUCTION: In this study, we investigated the correlation and clinical significance of peripheral blood leukocytes, neutrophils, C-reactive protein (CRP), and procalcitonin (PCT) in patients with acute urticaria. METHODS: Complete blood count with differential, CRP, and PCT tests were conducted on patients with acute urticaria. A total of 614 patients with acute urticaria were divided into three groups: the first group consisted of patients with elevated leukocyte and neutrophil count, the second group consisted of patients with normal leukocyte and neutrophil count, and the third group consisted of patients with abnormal leukocyte and neutrophil count...
March 18, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38490312/clinical-usefulness-of-a-host-signature-based-on-trail-ip10-and-crp-memed-bv-as-infection-biomarkers-in-intensive-care-units-patients-a-retrospective-observational-study
#16
JOURNAL ARTICLE
Karol P Steckiewicz, Magdalena A Wujtewicz, Michał Okrągły, Aleksander Aszkiełowicz, Malgorzata Dąbrowska, Radosław Owczuk
INTRODUCTION: Infection complications are common in intensive care unit patients, and early detection remains a diagnostic challenge. Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers. A novel diagnostic approach focuses on the host immune response. One of the novel approaches, the MMBV index, is based on measuring in a blood sample three parameters: (i) tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), (ii) interferon-γ-induced protein-10 (IP10), and (iii) CRP...
March 13, 2024: Clinical Biochemistry
https://read.qxmd.com/read/38488713/preliminary-report-of-extracorporeal-blood-purification-therapy-in-patients-receiving-lvad-cytosorb-or-jafron-ha330
#17
RANDOMIZED CONTROLLED TRIAL
Zhuldyz Nurmykhametova, Timur Lesbekov, Rymbay Kaliyev, Bolat Bekishev, Nilufar Jabayeva, Svetlana Novikova, Linar Faizov, Ivan Vakhrushev, Yuriy Pya
BACKGROUND: Left ventricular assist device (LVAD) candidates are at increased risk of immune dysregulation and infectious complications. To attenuate the elevated proinflammatory cytokine levels and associated adverse clinical outcomes, it has been postulated that extracorporeal blood purification could improve the overall survival rate and morbidity of patients undergoing LVAD implantation. METHODS: We retrospectively reviewed prospectively collected data of 15 patients who underwent LVAD implantation at our center between January 2021 and March 2022...
March 2024: Journal of Extra-corporeal Technology
https://read.qxmd.com/read/38487258/construction-and-validation-of-a-nomogram-model-to-predict-the-poor-prognosis-in-patients-with-pulmonary-cryptococcosis
#18
JOURNAL ARTICLE
Xiaoli Tan, Yingqing Zhang, Jianying Zhou, Wenyu Chen, Hua Zhou
BACKGROUND: Patients with poor prognosis of pulmonary cryptococcosis (PC) are prone to other complications such as meningeal infection, recurrence or even death. Therefore, this study aims to analyze the influencing factors in the poor prognosis of patients with PC, so as to build a predictive nomograph model of poor prognosis of PC, and verify the predictive performance of the model. METHODS: This retrospective study included 410 patients (78.1%) with improved prognosis of PC and 115 patients (21...
2024: PeerJ
https://read.qxmd.com/read/38485478/early-predictors-of-bacterial-pneumonia-infection-in-children-with-congenital-heart-disease-after-cardiopulmonary-bypass-a-single-centre-retrospective-study
#19
JOURNAL ARTICLE
Qingfeng Wang, Hui Liu, Liang Zou, Yueshuang Cun, Yaqin Shu, Nishant Patel, Di Yu, Xuming Mo
OBJECTIVES: The objective of this study was to evaluate the early predictors of bacterial pneumonia infection in children with congenital heart disease (CHD) after cardiopulmonary bypass (CPB). DESIGN: Retrospective study. SETTING: A freestanding tertiary paediatric hospital in China. PARTICIPANTS: Patients admitted to the hospital due to CHD who underwent open-heart surgery. OUTCOME MEASURES: We retrospectively reviewed and analysed data from 1622 patients with CHD after CPB from June 2018 to December 2020 at the Children's Hospital of Nanjing Medical University...
March 14, 2024: BMJ Open
https://read.qxmd.com/read/38474966/immunoassay-system-based-on-the-technology-of-time-resolved-fluorescence-resonance-energy-transfer
#20
JOURNAL ARTICLE
Zhengping Xu, Hong Zhou, Li Li, Zhang Chen, Xin Zhang, Yongtong Feng, Jianping Wang, Yuan Li, Yanfan Wu
To enhance the specificity and sensitivity, cut the cost, and realize joint detection of multiple indicators, an immunoassay system based on the technology of time-resolved fluorescence resonance energy transfer (TR-FRET) was studied. Due to the FRET of the reagent, the donor probe and acceptor probe emitted specific fluorescence to enhance specificity. Long-lifetime specific fluorescence from the acceptor probe was combined with time-resolved technology to enhance sensitivity. A xenon flash lamp and a photomultiplier tube (PMT) were selected as the light source and detector, respectively...
February 22, 2024: Sensors
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