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Renal denervation

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https://www.readbyqxmd.com/read/28089459/effect-of-renal-denervation-on-kidney-function-in-patients-with-chronic-kidney-disease
#1
Dagmara Hering, Petra Marusic, Jacqueline Duval, Yusuke Sata, Geoffrey A Head, Kate M Denton, Sally Burrows, Antony S Walton, Murray D Esler, Markus P Schlaich
AIMS: Renal denervation (RDN) can reduce blood pressure (BP) and slow the decline of renal function in chronic kidney disease (CKD) up to one year. Whether this effect is maintained beyond 12months and whether the magnitude of BP reduction affects estimated glomerular filtration rate (eGFR) is unknown. METHODS AND RESULTS: We examined eGFR in 46 CKD patients (baseline eGFR ≤60mL/min/1.73m(2)) on a yearly basis from 60months before to 3, 6, 12 and 24months after RDN...
January 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28079050/bipolar-radiofrequency-renal-denervation-with-the-vessix-catheter-in-patients-with-resistant-hypertension-2-year-results-from-the-reduce-htn-trial
#2
H Sievert, J Schofer, J Ormiston, U C Hoppe, I T Meredith, D L Walters, M Azizi, J Diaz-Cartelle
No abstract text is available yet for this article.
January 12, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28052866/renal-denervation-in-male-rats-with-heart-failure-improves-ventricular-sympathetic-nerve-innervation-and-function
#3
Maximilian Ichabod Pinkham, Michael T Loftus, Satya Amirapu, Sarah-Jane Guild, Gina Quill, William R Woodward, Beth A Habecker, Carolyn J Barrett
Heart failure is characterized by the loss of sympathetic innervation to the ventricles, contributing to impaired cardiac function and arrhythmogenesis. We hypothesized that renal denervation (RDx) would reverse this loss. Male Wistar rats underwent myocardial infarction (MI) or sham surgery and progressed into heart failure for four weeks before receiving bilateral RDx or sham RDx. After a further three weeks, left ventricular (LV) function was assessed and ventricular sympathetic nerve fibre density determined via histology...
January 4, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28044984/serial-quantitative-magnetic-resonance-angiography-follow-up-of-renal-artery-dimensions-following-treatment-by-four-different-renal-denervation-systems
#4
Laurens van Zandvoort, Matthijs van Kranenburg, Antonios Karanasos, Nicolas Van Mieghem, Mohammed Ouhlous, Robert-Jan van Geuns, Ron van Domburg, Joost Daemen
AIMS: Renal sympathetic denervation (RDN) is being studied as a therapeutic option for patients with therapy resistant hypertension. It remains unclear if the procedure affects the renal arteries in such a way that luminal narrowing might occur at the mid- to longer-term. METHODS AND RESULTS: In a prospective cohort of 27 patients referred for RDN, quantitative magnetic resonance angiography (MRA) was used to assess 52 vessels at baseline, 6-, and 12 months post treatment with one out of four different devices...
January 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28035730/chronic-kidney-disease-in-neurogenic-bladder
#5
Bong Mo Sung, Dong-Jin Oh, Moon Hee Choi, Hye Min Choi
AIM: It was believed that neurogenic bladder (NB) might be a risk factor of chronic kidney disease (CKD). However, data are limited regarding the real incidence or risk of CKD in NB. In addition, serum creatinine (sCr), a classical marker of renal function, is not reliable in NB patients because they present muscle wasting due to disuse or denervation. The aim of the study was to estimate the prevalence of CKD in NB patients using serum Cystatin-C. Secondly, we aimed to identify the risk factors for CKD development in NB...
December 30, 2016: Nephrology
https://www.readbyqxmd.com/read/28030955/reno-cerebral-reflex-activates-renin-angiotensin-system-promoting-oxidative-stress-and-renal-damage-after-ischemia-reperfusion-injury
#6
Wei Cao, Aiqing Li, Jiawen Li, Chunyi Wu, Shuang Cui, Zhanmei Zhou, Youhua Liu, Christopher Stuart Wilcox, Fan Fan Hou
AIMS: A kidney-brain interaction has been described in acute kidney injury but the mechanisms are uncertain. Since we recently described a reno-cerebral reflex, we tested the hypothesis that renal ischemia-reperfusion injury activates a sympathetic reflex that interlinks the renal and cerebral renin-angiotensin axis to promote oxidative stress and progression of the injury. RESULTS: Bilateral ischemia-reperfusion activated the intrarenal and cerebral, but not the circulating, renin-angiotensin system, increased sympathetic activity in the kidney and the cerebral sympathetic regulatory regions, and induced brain inflammation and kidney injury...
December 28, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28005705/denervation-of-the-distal-renal-arterial-branches-vs-conventional-main-renal-artery-treatment-a-randomized-controlled-trial-for-treatment-of-resistant-hypertension
#7
Stanislav E Pekarskiy, Andrei E Baev, Victor F Mordovin, Galina V Semke, Tatyana M Ripp, Alla U Falkovskaya, Valeria A Lichikaki, Ekaterina S Sitkova, Irina V Zubanova, Sergei V Popov
BACKGROUND: Effective treatment of uncontrolled hypertension using catheter-based percutaneous renal denervation may depend strongly on the anatomic strategy applied when delivering therapy. We hypothesized that concentering renal denervation treatment in the distal region of the artery would improve clinical response. METHODS AND RESULTS: We conducted a single-center, double-blind, randomized, controlled, and parallel group study (ClinicalTrials.gov NCT02667912)...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28003251/effect-of-arteriovenous-anastomosis-on-blood-pressure-reduction-in-patients-with-isolated-systolic-hypertension-compared-with-combined-hypertension
#8
Christian Ott, Melvin D Lobo, Paul A Sobotka, Felix Mahfoud, Alice Stanton, John Cockcroft, Neil Sulke, Eamon Dolan, Markus van der Giet, Joachim Hoyer, Stephen S Furniss, John P Foran, Adam Witkowski, Andrzej Januszewicz, Danny Schoors, Konstantinos Tsioufis, Benno J Rensing, Manish Saxena, Benjamin Scott, G André Ng, Stephan Achenbach, Roland E Schmieder
BACKGROUND: Options for interventional therapy to lower blood pressure (BP) in patients with treatment-resistant hypertension include renal denervation and the creation of an arteriovenous anastomosis using the ROX coupler. It has been shown that BP response after renal denervation is greater in patients with combined hypertension (CH) than in patients with isolated systolic hypertension (ISH). We analyzed the effect of ROX coupler implantation in patients with CH as compared with ISH...
December 21, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27988231/effects-of-percutaneous-renal-sympathetic-denervation-on-cardiac-function-and-exercise-tolerance-in-patients-with-chronic-heart-failure
#9
Jun-Qing Gao, Yun Xie, Wei Yang, Jian-Pu Zheng, Zong-Jun Liu
INTRODUCTION: Sympathetic hyperactivity, a vital factor in the genesis and development of heart failure (HF), has been reported to be effectively reduced by percutaneous renal denervation (RDN), which may play an important role in HF treatment. OBJECTIVE: To determine the effects of percutaneous RDN on cardiac function in patients with chronic HF (CHF). METHODS: Fourteen patients (mean age 69.6 years; ejection fraction [EF] <45%) with CHF received bilateral RDN...
January 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27979323/renal-denervation-in-heart-failure-modulating-the-sympathetic-nervous-system
#10
Joana Delgado Silva
No abstract text is available yet for this article.
January 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27970156/tct-768-histopathological-features-of-transcatheter-renal-denervation-by-radiofrequency-ablation-compared-to-the-effects-following-chemical-ablation-by-perivascular-delivery-of-a-novel-neurotropic-agent-a-preclinical-perspective
#11
Armando Tellez, Krista N Dillon, Emily A Stein, K T Rao, Dane A Brady, Serge Rousselle
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970155/tct-766-catheter-guided-renal-denervation-used-for-the-treatment-of-heart-failure-with-reduced-ejection-fraction-a-meta-analysis
#12
Mohammad Ansari, Daniel Garcia
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970154/tct-767-effect-of-renal-artery-denervation-on-heart-rate-insights-from-a-systematic-review-and-meta-analysis
#13
Bora Toklu, Franz H Messerli, Stefano F Rimoldi, Sripal Bangalore
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970150/tct-764-effects-of-multielectrode-renal-denervation-on-sympathetic-nerve-activity-and-insulin-resistance-in-metabolic-syndrome
#14
Konstantinos Tsioufis, Kyriakos Dimitriadis, Alexandros Kasiakogias, Theodoros Kalos, Ioannis Liatakis, Evaggelia Koutra, Lefki Nikolopoulou, Rita Ella, Elizabeth Lau, Vasilios Papademetriou, Dimitrios Tousoulis
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970149/tct-765-renal-sympathetic-denervation-impact-on-hypertensive-disease
#15
Ana Rita Francisco, Miguel Nobre Menezes, Alexandra Lopes, Helena Correia, Eduardo Infante de Oliveira, Pedro Canas da Silva, Fausto J Pinto
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970148/tct-761-long-term-3-year-safety-and-effectiveness-from-the-global-symplicity-registry-of-renal-denervation-in-a-real-world-patient-population-with-uncontrolled-hypertension
#16
Felix Mahfoud, Nicole Brilakis, Michael Böhm, Krzysztof Narkiewicz, Luis Ruilope, Markus Schlaich, Giuseppe Mancia
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970147/tct-762-renal-denervation-treatment-with-the-symplicity-spyral-multielectrode-catheter-6-month-safety-and-blood-pressure-outcomes-from-the-global-symplicity-registry
#17
Michael Böhm, Nicole Brilakis, Giuseppe Mancia, Krzysztof Narkiewicz, Luis Ruilope, Markus Schlaich, Felix Mahfoud
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970146/tct-763-alcohol-mediated-renal-denervation-current-status-and-future-directions
#18
Wojtek Wojakowski, Nicole Haratani, Felix Vega
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27957627/blood-pressure-response-to-catheter-based-renal-sympathetic-denervation-in-severe-resistant-hypertension-data-from-the-greek-renal-denervation-registry
#19
C Tsioufis, A Ziakas, K Dimitriadis, P Davlouros, M Marketou, A Kasiakogias, C Thomopoulos, D Petroglou, D Tsiachris, M Doumas, E Skalidas, C Karvounis, D Alexopoulos, P Vardas, I Kallikazaros, C Stefanadis, V Papademetriou, D Tousoulis
BACKGROUND/INTRODUCTION: The efficacy of catheter-based renal sympathetic denervation (RDN) in terms of blood pressure (BP) reduction has been questioned, while "real-world" data from registries are needed. In this study, we report the complete set of 12-month data on office and ambulatory BP changes as well as the predictors for BP response to RDN from a national registry. METHODS: In 4 Greek hospital centers, 79 patients with severe drug-resistant hypertension (age 59 ± 10 years, 53 males, body mass index 33 ± 5 kg/m(2); office BP and 24-h ambulatory BP were 176 ± 15/95 ± 13 and 155 ± 14/90 ± 12 mmHg, respectively, 4...
December 12, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27957419/pulmonary-vein-isolation-alone-and-combined-with-renal-sympathetic-denervation-in-chronic-kidney-disease-patients-with-refractory-atrial-fibrillation
#20
Márcio G Kiuchi, Shaojie Chen, Gustavo R E Silva, Luis M R Paz, Tetsuaki Kiuchi, Ary G de Paula Filho, Gladyston L L Souto
BACKGROUND: Atrial fibrillation (AF) commonly occurs in association with chronic kidney disease (CKD), resulting in adverse outcomes. Combining pulmonary vein isolation (PVI) and renal sympathetic denervation (RSD) may reduce the recurrence of AF in patients with CKD and hypertension. We considered that RSD could reduce the recurrence of AF in patients with CKD by modulating sympathetic hyperactivity. Our goal was to compare the impact of PVI + RSD with that of PVI alone in patients with concurrent AF and CKD...
December 2016: Kidney Research and Clinical Practice
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