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Renal denervation

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https://www.readbyqxmd.com/read/29104628/renal-sympathetic-denervation-improves-myocardial-apoptosis-in-rats-with-isoproterenol-induced-heart-failure-by-downregulation-of-tumor-necrosis-factor-%C3%AE-and-nuclear-factor-%C3%AE%C2%BAb
#1
Wei Yao, Neng Wang, Jin Qian, Lu Bai, Xiaoxin Zheng, Guo Hou, Xuan Qiu, Bo Yang
Chronic congestive heart failure (CHF) is the end outcome of organic heart diseases and one of the major diseases harmful to human health. Renal sympathetic denervation (RSD) is the anatomical basis of transcatheter renal sympathetic nerve ablation within the renal artery. To date, the roles of norepinephrine and angiotensin II (Ang II) in myocardial apoptosis and their underlying mechanisms have not been well explored. The aim of the present study was to verify the hypothesis that RSD is likely to inhibit myocardial apoptosis by inhibiting the release of norepinephrine and Ang II...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29094471/antifibrillatory-effects-of-renal-denervation-on-ventricular-fibrillation-in-a-canine-model-of-pacing-induced-heart-failure
#2
Qingzhi Luo, Qi Jin, Ning Zhang, Shangwei Huang, Yanxin Han, Changjian Lin, Tianyou Ling, Kang Chen, Wenqi Pan, Liqun Wu
This study investigated the effects of renal denervation (RDN) on vulnerability to ventricular fibrillation (VF) and ventricular electrical properties in a canine model of pacing-induced heart failure (HF). Eighteen beagles were divided into the following three groups: control (n = 6), HF (n = 6) and HF+RDN (n = 6). HF was induced by rapid right ventricular pacing. RDN was performed simultaneously with the pacemaker implantation in the HF+RDN group. A 64-unipolar basket catheter was used to perform global endocardial mapping of the left ventricle...
November 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29082259/effects-of-renal-denervation-on-insulin-sensitivity-and-inflammatory-markers-in-nondiabetic-patients-with-treatment-resistant-hypertension
#3
Ulla Kampmann, Ole N Mathiassen, Kent L Christensen, Niels H Buus, Mette Bjerre, Henrik Vase, Niels Møller, Anne Kaltoft, Per L Poulsen
Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance. Afferent signaling from the kidneys elevates the central sympathetic drive. We investigated the effect of catheter-based renal sympathetic denervation (RDN) on glucose metabolism, inflammatory markers, and blood pressure in nondiabetic patients with treatment-resistant hypertension. Eight subjects were included in an open-labelled study. Each patient was studied before and 6 months after RDN. Endogenous glucose production was assessed by a 3-(3)H glucose tracer, insulin sensitivity was examined by hyperinsulinemic euglycemic clamp, hormones and inflammatory markers were analyzed, and blood pressure was measured by office blood pressure readings and 24-hour ambulatory blood pressure monitoring...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29070043/the-effect-of-renal-denervation-in-an-experimental-model-of-chronic-renal-insufficiency-the-remnant-kidney-denervation-in-pigs-study-redip-study
#4
Jean-Claude Lubanda, Miroslav Chochola, Mikuláš Mlček, Petr Neužil, Josef Marek, Štěpán Havránek, Sylvie Kuchynková, Zdeňka Fingrová, Kao-Hsuan Aimee Huang, Aleš Linhart
BACKGROUND: Renal denervation (RDN) is a promising therapeutic method in cardiology. Its currently most investigated indication is resistant hypertension. Other potential indications are atrial fibrillation, type 2 diabetes mellitus and chronic renal insufficiency among others. Previous trials showed conflicting but promising results, but the real benefits of RDN are still under investigation. Patients with renal insufficiency and resistant hypertension are proposed to be a good target for this therapy due to excessive activation of renal sympathetic drive...
October 25, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29069927/how-to-perform-a-cost-effectiveness-analysis-with-surrogate-endpoint-renal-denervation-in-patients-with-resistant-hypertension-denerhtn-trial-as-an-example
#5
Julie Bulsei, Meryl Darlington, Isabelle Durand-Zaleski, Michel Azizi
Whilst much uncertainty exists as to the efficacy of renal denervation (RDN), the positive results of the DENERHTN study in France confirmed the interest of an economic evaluation in order to assess efficiency of RDN and inform local decision makers about the costs and benefits of this intervention. The uncertainty surrounding both the outcomes and the costs can be described using health economic methods such as the non-parametric bootstrap. Internationally, numerous health economic studies using a cost-effectiveness model to assess the impact of RDN in terms of cost and effectiveness compared to antihypertensive medical treatment have been conducted...
October 26, 2017: Blood Pressure
https://www.readbyqxmd.com/read/29061728/central-iliac-arteriovenous-anastomosis-for-uncontrolled-hypertension-one-year-results-from-the-rox-control-htn-trial
#6
Melvin D Lobo, Christian Ott, Paul A Sobotka, Manish Saxena, Alice Stanton, John R Cockcroft, Neil Sulke, Eamon Dolan, Markus van der Giet, Joachim Hoyer, Stephen S Furniss, John P Foran, Adam Witkowski, Andrzej Januszewicz, Danny Schoors, Konstantinos Tsioufis, Benno J Rensing, Benjamin Scott, G André Ng, Roland E Schmieder
Creation of a central iliac arteriovenous anastomosis using a novel nitinol coupler device results in an immediate, significant reduction of blood pressure (BP). We present efficacy and safety findings at 12 months post-coupler insertion. This open-label, multicenter, prospective, randomized trial enrolled patients with a baseline office systolic BP ≥140 mm Hg and average daytime ambulatory BP ≥135/85 mm Hg. Subjects were randomly allocated to coupler implantation and continuing previous pharmacotherapy or to maintain previous treatment alone...
October 23, 2017: Hypertension
https://www.readbyqxmd.com/read/29059859/increased-arterial-stiffness-does-not-respond-to-renal-denervation-in-an-animal-model-of-secondary-hypertension
#7
Yimin Yao, Cara M Hildreth, Sheran Li, Rochelle Boyd, Zahra Kouchaki, Mark Butlin, Alberto P Avolio, Paul M Pilowsky, Jacqueline K Phillips
Renal denervation is a novel device based therapy promoted to reduce high blood pressure. We examined the impact of renal denervation on systolic blood pressure, renal function, and arterial stiffness in the Lewis Polycystic Kidney disease (LPK) rodent model of kidney disease. Animals were subjected to bilateral renal denervation or sham surgeries at age 6 and 12 weeks. Systolic blood pressure was monitored by tail-cuff plethysmography and renal function by urinalysis and creatinine clearance. At age 16 weeks, beat-to-beat aortic pulse wave velocity as a functional indicator of arterial stiffness was determined...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059404/catheter-based-renal-denervation-and-renal-function-no-evidence-of-harm-but-is-there-a-hope-of-nephroprotection
#8
Andrzej Wiecek
No abstract text is available yet for this article.
September 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29059396/renal-safety-of-catheter-based-renal-denervation-systematic-review-and-meta-analysis
#9
Margreet F Sanders, Johannes B Reitsma, Moira Morpey, Hendrik Gremmels, Michiel L Bots, Anna Pisano, Davide Bolignano, Carmine Zoccali, Peter J Blankestijn
Background: Catheter-based renal denervation (RDN) is a possible treatment to lower blood pressure. The invasive nature of RDN and the use of contrast agents raise concerns about potential consequent kidney damage. Our objective was to determine the change in renal function after RDN by performing a systematic review on hypertensive patients treated with RDN. Methods: A systematic search was performed in the Embase and MEDLINE databases to identify studies reporting on the effects of catheter-based RDN on renal outcome...
September 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29056958/renal-artery-denervation-suppresses-intractable-ventricular-arrhythmia-in-patients-with-left-heart-thrombosis
#10
Marianna A Vander, Petr A Fedotov, Tamara A Lyubimtseva, Maria A Bortsova, Maria Yu Sitnikova, Dmitry S Lebedev, Evgeny N Mikhaylov
No abstract text is available yet for this article.
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29056558/spyral-htn-off-med-study-renal-denervation-in-the-spiral-orbits-of-current-results-and-future-studies
#11
EDITORIAL
Costas Tsioufis, Kyriakos Dimitriadis, Vasilios Papademetriou, Dimitrios Tousoulis
No abstract text is available yet for this article.
October 19, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29051307/effect-of-renal-denervation-on-urine-angiotensinogen-excretion-in-prenatally-programmed-rats
#12
Asifhusen Mansuri, Susan K Legan, Jyoti Jain, Issa Alhamoud, Jyothsna Gattineni, Michel Baum
Prenatal programming results in an increase in blood pressure in adult offspring. We have shown that compared to control adult offspring whose mothers were fed a 20% protein diet, programmed adults whose mothers were fed a 6% protein diet during the last half of pregnancy have an increase in renal sympathetic nerve activity and urinary angiotensinogen/creatinine levels. We hypothesized that the increase in urinary angiotensinogen was mediated by renal sympathetic nerve activity in programmed rats. In this study performed in 3 month old rats, renal denervation resulted in normalization of blood pressure in the 6% programmed group (150 ± 3 Hg in 6% sham vs...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29050562/renal-sympathetic-denervation-protects%C3%A2-the-failing-heart-via-inhibition-of%C3%A2-neprilysin%C3%A2-activity-in-the-kidney
#13
David J Polhemus, Rishi K Trivedi, Juan Gao, Zhen Li, Amy L Scarborough, Traci T Goodchild, Kurt J Varner, Huijing Xia, Frank W Smart, Daniel R Kapusta, David J Lefer
BACKGROUND: Sustained sympathetic activation contributes to the progression of myocardial cell injury, cardiac fibrosis, and left ventricular (LV) dysfunction in heart failure (HF). OBJECTIVES: This study investigated the effects of radiofrequency renal nerve denervation (RF-RDN) on the pathobiology of HF and the interaction between the renal sympathetic nerves and natriuretic peptide (NP) metabolism. METHODS: Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were subjected to 45 min of coronary artery ligation and reperfusion for 12 weeks...
October 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29045339/blood-pressure-response-to-renal-denervation-is-correlated-with-baseline-blood-pressure-variability-a-patient-level-meta-analysis
#14
Alexandre Persu, Daniel Gordin, Lotte Jacobs, Lutgarde Thijs, Michiel L Bots, Wilko Spiering, Atena Miroslawska, Jonas Spaak, Ján Rosa, Mark R de Jong, Elena Berra, Fadl Elmula M Fadl Elmula, Grégoire Wuerzner, Alison H M Taylor, Agnieszka Olszanecka, Danuta Czarnecka, Patrick B Mark, Michel Burnier, Jean Renkin, Sverre E Kjeldsen, Jiří Widimský, Arif Elvan, Thomas Kahan, Terje K Steigen, Peter J Blankestijn, Ilkka Tikkanen, Jan A Staessen
BACKGROUND: Sympathetic tone is one of the main determinants of blood pressure (BP) variability and treatment-resistant hypertension. The aim of our study was to assess changes in BP variability after renal denervation (RDN). In addition, on an exploratory basis, we investigated whether baseline BP variability predicted the BP changes after RDN. METHODS: We analyzed 24-h BP recordings obtained at baseline and 6 months after RDN in 167 treatment-resistant hypertension patients (40% women; age, 56...
October 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29042091/effects-of-renal-denervation-on-coronary-flow-reserve-and-forearm-dilation-capacity-in-patients-with-treatment-resistant-hypertension-a-randomized-double-blinded-sham-controlled-clinical-trial
#15
Morten Engholm, Jannik B Bertelsen, Ole N Mathiassen, Hans E Bøtker, Henrik Vase, Christian D Peters, Jesper N Bech, Niels H Buus, Anne P Schroeder, Hans Rickers, Klavs W Hansen, Per L Poulsen, Anne Kaltoft, Kent L Christensen
BACKGROUND: Microvascular impairment is well documented in hypertension. We investigated the effect of renal sympathetic denervation (RDN) on cardiac and peripheral microvasculature in patients with treatment-resistant essential hypertension (TRH). METHODS: A randomized, single centre, double-blinded, sham-controlled clinical trial. Fifty-eight patients with TRH (ambulatory systolic BP (ASBP) ≥ 145mmHg) despite stable treatment were randomized to RDN or SHAM. RDN was performed with the unipolar Medtronic Flex catheter...
October 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29041878/-influence-of-sympathetic-denervation-of-the-renal-artery-on-the-level-of-arterial-blood-pressure-cerebral-blood-flow-and-cognitive-function-in-patients-with-resistant-arterial-hypertension
#16
Y N Efimova, A V Lichikaki, B Y Lishmanov
PURPOSE: To study the effect of radiofrequency ablation of renal arteries on regional cerebral blood flow and cognitive function in patients with resistant arterial hypertension (AH). MATERIAL AND METHODS: Transcatheter renal denervation (TRD) was performed in 17 patients with resistant AH. Examination before and after TRD included SPECT with mTc-HMPAO, 24-hours blood pressure (BP) monitoring, and comprehensive neuropsychological testing. Fifteen patients without angiographic signs of carotid atherosclerosis, coronary artery disease and AH, neurological and psychiatric disorders were investigated as control group...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29038200/renal-denervation-after-the-spyral-htn-off-med-trial-putting-a-complex-study-into-context
#17
EDITORIAL
Markus P Schlaich, Murray D Esler
No abstract text is available yet for this article.
October 16, 2017: Hypertension
https://www.readbyqxmd.com/read/29035942/phase-ii-randomized-sham-controlled-study-of-renal-denervation-for-individuals-with-uncontrolled-hypertension-wave-iv
#18
Roland E Schmieder, Christian Ott, Stefan W Toennes, Peter Bramlage, Michael Gertner, Omar Dawood, Peter Baumgart, Benjamin O'Brien, Indranil Dasgupta, Georg Nickenig, John Ormiston, Manish Saxena, Andrew S P Sharp, Horst Sievert, Jindrich Spinar, Zdenek Starek, Joachim Weil, Ulrich Wenzel, Adam Witkowski, Melvin D Lobo
OBJECTIVES: The aim of this double-blind, randomized, sham-controlled study was to verify the blood pressure (BP)-lowering efficacy of externally delivered focused ultrasound for renal denervation (RDN). BACKGROUND: Nonrandomized, first proof-of-concept study and experimental evidence suggested that noninvasive techniques of RDN emerged as an alternative approach of RDN to invasive technologies. METHODS: WAVE IV, an international, randomized (1 : 1) sham-controlled, double-blind prospective clinical study, was prematurely stopped...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29034650/a-complicated-case-of-resistant-hypertension
#19
Mauro Chiarito, Andrea Scotti, Carlo A Pivato, Giuseppe Cottone, Carlo Ballarotto, Cosmo Godino, Alberto Margonato
A 47-year-old woman presented with a history of resistant arterial hypertension, associated with disabling headache. She was subjected to an enormous number of tests in order to identify an underlying cause of secondary hypertension, such as pheochromocytoma or Cushing syndrome, but all the most common causes of secondary hypertension were investigated and gradually excluded. Factitious use of amphetamine or cocaine was excluded, and therapy compliance was verified by witnessed ingestion of drug therapy, in order to rule out Munchausen syndrome...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29034356/renal-denervation-reduces-pulmonary%C3%A2-vascular-remodeling-and-right-ventricular-diastolic-stiffness-in-experimental-pulmonary-hypertension
#20
Denielli da Silva Gonçalves Bos, Chris Happé, Ingrid Schalij, Wioletta Pijacka, Julian F R Paton, Christophe Guignabert, Ly Tu, Raphaël Thuillet, Harm-Jan Bogaard, Albert C van Rossum, Anton Vonk-Noordegraaf, Frances S de Man, M Louis Handoko
Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system...
February 2017: JACC. Basic to Translational Science
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