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Renal denervation

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https://www.readbyqxmd.com/read/28453557/perivascular-radiofrequency-renal-denervation-lowers-blood-pressure-and-ameliorates-cardiorenal-fibrosis-in-spontaneously-hypertensive-rats
#1
Shujie Wei, Dan Li, Yan Zhang, Linan Su, Yunrong Zhang, Qiang Wang, Dachun Yang, De Li, Yongjian Yang, Shuangtao Ma
BACKGROUND: Catheter-based renal denervation (RDN) is a promising approach to treat hypertension, but innervation patterns limit the response to endovascular RDN and the post-procedural renal artery narrowing or stenosis questions the endovascular ablation strategy. This study was performed to investigate the anti-hypertensive and target organ protective effects of perivascular RDN in spontaneously hypertensive rats (SHR). METHODS: SHR and normotensive Wistar-Kyoto (WKY) rats were divided into sham group (n = 10), radiofrequency ablation group (n = 20) in which rats received bilateral perivascular ablation with radiofrequency energy (2 watts), and chemical (10% phenol in 95% ethanol) ablation group (n = 12)...
2017: PloS One
https://www.readbyqxmd.com/read/28448180/renal-denervation-decreases-blood-pressure-and-renal-tyrosine-hydroxylase-but-does-not-augment-the-effect-of-hypotensive-drugs
#2
Janusz Skrzypecki, Maciej Gawlak, Tomasz Huc, Paweł Szulczyk, Marcin Ufnal
The effect of renal denervation on the efficacy of antihypertensive drugs has not yet been elucidated. Twenty-week-old spontaneously hypertensive rats were treated with metoprolol, losartan, indapamide, or saline (controls) and assigned to renal denervation or a sham procedure. Acute hemodynamic measurements were performed ten days later. Series showing a significant interaction between renal denervation and the drugs were repeated with chronic telemetry measurements. In the saline series, denervated rats showed a significantly lower mean arterial blood pressure (blood pressure) than the sham-operated rats...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28445258/renal-vascular-calcification-and-response-to-renal-nerve-denervation-in-resistant-hypertension
#3
Annemiek F Hoogerwaard, Mark R de Jong, Ahmet Adiyaman, Jaap Jan J Smit, Peter P H M Delnoy, Jan-Evert Heeg, Boudewijn A A M van Hasselt, Anand R Ramdat Misier, Arif Elvan
Renal sympathetic nerve denervation (RDN) is accepted as a treatment option for patients with resistant hypertension. However, results on decline in ambulatory blood pressure (BP) measurement (ABPM) are conflicting. The high rate of nonresponders may be related to increased systemic vascular stiffness rather than sympathetic overdrive. A single center, prospective registry including 26 patients with treatment resistant hypertension who underwent RDN at the Isala Hospital in the Netherlands. Renal perivascular calcium scores were obtained from noncontrast computed tomography scans...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445207/effect-of-renal-sympathetic-denervation-on-short-term-blood-pressure-variability-in-resistant-hypertension-a-meta-analysis
#4
Nikos Vogiatzakis, Costas Tsioufis, Georgios Georgiopoulos, Costas Thomopoulos, Kyriakos Dimitriadis, Alexandros Kasiakogias, Dimitrios Konstantinidis, Thodoris Kalos, Felix Mahfoud, Michael Doumas, Vasilios Papademetriou, Dimitrios Tousoulis
BACKGROUND/OBJECTIVES: Short-term blood pressure variability (BPV) is affected by multiple factors including the sympathetic nervous system drive. Regarding the latter, the novel interventional technology of renal denervation (RDN), by modulating the sympathetic system activation, could have a beneficial impact on BPV. The aim of the current study is to review and meta-analyze the available evidence on the effect of RDN on short-term BPV. METHODS: We searched Medline/PubMed database until October 2016 for studies with eligible content...
April 25, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28443356/sham-or-no-sham-control-that-is-the-question-in-trials-of-renal-denervation-for-resistant-hypertension-a-systematic-meta-analysis
#5
Fadl Elmula M Fadl Elmula, Ying-Mei Feng, Lotte Jacobs, Anne C Larstorp, Sverre E Kjeldsen, Alexandre Persu, Jan A Staessen
BACKGROUND: Studies of renal denervation (RDN) in patients with apparent treatment resistant hypertension have been hampered by a number of patient and physician related confounders on blood pressure (BP) including poor drug adherence. It remains uncertain whether RDN lowers BP. We aimed to investigate whether the use of sham control is essential in RDN studies or whether systematic use of 24-hour ambulatory BP provides enough information thereby making an invasive sham control redundant...
April 26, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28441700/ultrasound-based-renal-sympathetic-denervation-for-the-treatment-of-therapy-resistant-hypertension-a-single-center-experience
#6
Karl Fengler, Robert Höllriegel, Thomas Okon, Thomas Stiermaier, Karl-Philipp Rommel, Stephan Blazek, Christian Besler, Max von Roeder, Martin Petzold, Gerhard Schuler, Philipp Lurz
INTRODUCTION: The effectiveness of renal sympathetic denervation (RDN) as a treatment for therapy-resistant hypertension has been doubted as the Simplicity-HTN-3 trial was unable to show any treatment benefit over sham procedure. This might partly be explained by a high procedural variability in treatment with radiofrequency-based catheters. Recently, newer systems for RDN, like ultrasound-based devices, have been introduced into practice. To date however, data on their effectiveness for the treatment of resistant hypertension are scarce...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28436415/blood-pressure-reduction-in-patients-with-accessory-renal-arteries-and-bilateral-single-renal-arteries-after-catheter-based-renal-denervation-prospective-study-with-3-year-follow-up
#7
Krzysztof Bartus, Jakub Podolec, Jerzy Sadowski, Radosław Litwinowicz, Wojciech Zajdel, Magdalena Bartus, Janusz Konstanty-Kalandyk, Artur Dziewierz, Rafał Trąbka, Stanisław Bartus, Anna Chrapusta, Bogusław Kapelak
INTRODUCTION    Catheter-based renal denervation is an effective treatment leading to significant reduction of systolic and diastolic blood pressure in patients with resistant hypertension. OBJECTIVES    The aim of this prospective study was to assess the BP-lowering effect and pulse pressure lowering effects in patients with accessory and bilateral single renal arteries after catheter-based renal denervation procedure in a 3-year follow-up period. PATIENTS AND METHODS    31 patients with diagnosed resistant hypertension were enrolled in this study...
April 24, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28423234/pulmonary-vein-isolation-with%C3%A2-concomitant%C3%A2-renal-artery-denervation%C3%A2-is-associated-with-reduction-of-both-arterial-blood-pressure-and-atrial-fibrillation-burden-data-from-implantable-cardiac-monitor
#8
Alexander Romanov, Evgeny Pokushalov, Dmitry Ponomarev, Artem Strelnikov, Vitaliy Shabanov, Denis Losik, Alexander Karaskov, Jonathan S Steinberg
BACKGROUND: Renal artery denervation (RDN) has provided incremental atrial fibrillation (AF) suppression after pulmonary vein isolation (PVI) in patients with AF in the setting of drug-resistant hypertension. OBJECTIVE: To assess the relationship between changes of mean blood pressure (BP) and AF recurrences/AF burden after PVI combined with RDN. METHODS: All patients from two randomized studies with symptomatic paroxysmal AF and/or persistent AF and resistant hypertension who underwent PVI only (n=37) or PVI with RDN (n=39), and implantable cardiac monitor (ICM) implantation, were eligible for this study...
April 19, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28421719/therapeutic-value-of-renal-denervation-in-cardiovascular-disease
#9
EDITORIAL
M Carlstrom
No abstract text is available yet for this article.
May 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28416585/case-of-refractory-hypertension-controlled-by-repeated-renal-denervation-and-celiac-plexus-block-a-case-of-refractory-sympathetic-overload
#10
Chan Joo Lee, Byeong-Keuk Kim, Kyung Bong Yoon, Hae-Young Lee, Anna F Dominiczak, Rhian M Touyz, Garry L R Jennings, Eun Joo Cho, Dagmara Hering, Sungha Park
No abstract text is available yet for this article.
April 17, 2017: Hypertension
https://www.readbyqxmd.com/read/28415795/renal-sympathetic-denervation-guided-by-renal-nerve-stimulation-to-treat-ventricular-arrhythmia-in-ckd-patients-with-icd
#11
Márcio Galindo Kiuchi, Shaojie Chen, Luis Marcelo Rodrigues Paz, Helmut Pürerfellner
Chronic kidney disease (CKD) patients on stage 4 present greater risk rates for malignant ventricular arrhythmia events. This study examined patients with CKD in stages 1, 2, 3 and 4, left ventricular dysfunction and automatic implantable cardioverter-defibrillator (ICD). Our goal was to record the appropriate therapies, "Anti-tachycardia Therapy Pacing" (ATP) and shock events during the 18 months of follow-up and compare the incidence and severity of these at different stages of CKD, mainly in patients with CKD stage 4 underwent renal sympathetic denervation (RSD) guided by renal nerve stimulation (RNS)...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413968/hypertension-and-heart-failure-with-preserved-ejection-fraction-connecting-the-dots
#12
Costas Tsioufis, Georgios Georgiopoulos, Dimitrios Oikonomou, Costas Thomopoulos, Niki Katsiki, Alexandros Kasiakogias, Christina Chrysochoou, Dimitrios Konstantinidis, Theodoros Kalos, Dimitrios Tousoulis
Heart failure (HF) with preserved ejection fraction (EF) (HFpEF) accounts for approximately 50% of HF cases and its prevalence relative to HF with reduced EF is rising. Hypertension (HT) is the most common co-morbidity in HFpEF patients and it is implicated in both the pathogenesis and the prognosis of the disease. Therefore, HT is a modifiable risk factor of high yield in HFpEF. We reviewed the literature for epidemiologic data supporting the co-aggregation of the two entities as well as patho-physiologic mechanisms linking HT to HFpEF...
April 14, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28411899/device-directed-therapy-for-resistant-hypertension
#13
REVIEW
Sinan S Tankut, Ayhan Yoruk, John D Bisognano
Hypertension remains a significant risk factor for an array of diseases despite advancements in pharmacotherapy. Patients with resistant hypertension who do not respond to conventional medical treatments and lifestyle modifications are especially at risk for poor health outcomes. With the increasing awareness of resistant hypertension, ever-evolving research efforts continue to focus on innovative interventions, including renal denervation, median nerve stimulation, and baroreceptor activation therapy. This article reviews the current evidence and summarizes previous clinical trials for each of these interventions...
May 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/28411074/low-dose-sustained-release-deoxycorticosterone-acetate-induced-hypertension-in-bama-miniature-pigs-for-renal-sympathetic-nerve-denervation
#14
Wenzheng Han, Weiyi Fang, Qian Gan, Shaofeng Guan, Yanjie Li, Ming Wang, Kaizheng Gong, Xinkai Qu
Recently, the effectiveness of renal sympathetic nerve denervation for treatment of hypertension has been doubted after SYMPLICITY HTN-3 trial. An ideal animal model is still unavailable for preclinical study about catheter-based renal sympathetic nerve denervation for treatment of hypertension. Traditional high-dose deoxycorticosterone acetate (DOCA)-induced hypertension pig model has some problems due to extensive end-organ damage. Based on the similarity in the anatomic characteristics of renal artery between pigs and humans, this study was undertaken to establish a low-dose sustained-release DOCA-induced hypertension model in pigs...
March 2, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28406699/early-morphologic-alterations-in-renal-artery-wall-and-renal-nerves-in-response-to-catheter-based-renal-denervation-procedure-in-sheep-difference-between-single-point-and-multiple-point-ablation-catheters
#15
M Táborský, D Richter, Z Tonar, T Kubíková, A Herman, J Peregrin, L Červenková, Z Husková, L Kopkan
Renal sympathetic hyperactivity is critically involved in hypertension pathophysiology; renal denervation (RDN) presents a novel strategy for treatment of resistant hypertension cases. This study assessed effects of two RDN systems to detect acute intravascular, vascular and peri-vascular changes in the renal artery, and renal nerve alterations, in the sheep. The procedures using a single-point or multi-point ablation catheters, Symplicity Flex(TM), Medtronic versus EnligHTN(TM), St. Jude Medical were compared; the intact contralateral kidneys served as controls...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28405824/redo-renal-denervation-using-a%C3%A2-multi-electrode-radiofrequency-system-in-patients-with-persistent-therapy-resistant-hypertension
#16
J Daemen, L Feyz, L Van Zandvoort, N M Van Mieghem
OBJECTIVES: Renal sympathetic denervation has been studied as a potential therapeutic option for patients with therapy-resistant hypertension; however, a significant proportion of patients do not show a significant reduction in blood pressure and are classified as non-responders. The objective of the present study was to assess whether a redo renal denervation procedure increases response rates. METHODS: We present a case series of three consecutive renal denervation non-responders treated with the multi-electrode radiofrequency St...
April 12, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28394333/a-heart-brain-kidney-network-controls-adaptation-to-cardiac-stress-through-tissue-macrophage-activation
#17
Katsuhito Fujiu, Munehiko Shibata, Yukiteru Nakayama, Fusa Ogata, Sahohime Matsumoto, Koji Noshita, Shingo Iwami, Susumu Nakae, Issei Komuro, Ryozo Nagai, Ichiro Manabe
Heart failure is a complex clinical syndrome characterized by insufficient cardiac function. In addition to abnormalities intrinsic to the heart, dysfunction of other organs and dysregulation of systemic factors greatly affect the development and consequences of heart failure. Here we show that the heart and kidneys function cooperatively in generating an adaptive response to cardiac pressure overload. In mice subjected to pressure overload in the heart, sympathetic nerve activation led to activation of renal collecting-duct (CD) epithelial cells...
April 10, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28391220/renal-denervation-for-treatment-of-hypertension-will-2017-be-the-year-of-enlightenment
#18
Felix Mahfoud, Elazer R Edelman
No abstract text is available yet for this article.
April 7, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28383187/renal-denervation-in-less-severe-forms-of-resistant-hypertension-quo-vadis
#19
Markus P Schlaich, Dagmara Hering, Yusuke Sata
No abstract text is available yet for this article.
April 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28377560/recent-advances-in-the-pathophysiology-of-arterial-hypertension-potential-implications-for-clinical-practice
#20
Dagmara Hering, Andrzej Trzebski, Krzysztof Narkiewicz
Hypertension remains a major and growing public health problem associated with the greatest global rate of cardiovascular morbidity and mortality. Although numerous factors contribute to poor control of blood pressure (BP) and to pseudoresistance (eg, unawareness, lifestyle habits, nonadherence to medication, insufficient treatment, drug‑induced hypertension, undiagnosed secondary causes), true resistant hypertension (RH) is reported in 10.1% of patients treated for elevated BP. While the mechanisms underlying RH remain complex and not entirely understood, sympathetic activation involved in the pathophysiology of hypertension, disease progression, and adverse complications is further augmented in patients with drug‑resistant hypertension...
March 1, 2017: Polish Archives of Internal Medicine
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