Valentina Eberlein, Sophia Rosencrantz, Julia Finkensieper, Joana Kira Besecke, Yaser Mansuroglu, Jan-Christopher Kamp, Franziska Lange, Jennifer Dressman, Simone Schopf, Christina Hesse, Martin Thoma, Jasmin Fertey, Sebastian Ulbert, Thomas Grunwald
The respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections associated with numerous hospitalizations. Recently, intramuscular (i.m.) vaccines against RSV have been approved for elderly and pregnant women. Noninvasive mucosal vaccination, e.g., by inhalation, offers an alternative against respiratory pathogens like RSV. Effective mucosal vaccines induce local immune responses, potentially resulting in the efficient and fast elimination of respiratory viruses after natural infection...
2024: Frontiers in Immunology