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Roberta Assante, Alberto Cuocolo
No abstract text is available yet for this article.
March 15, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Elinor Goshen, Leonid Beilin, Eli Stern, Tal Kenig, Ronen Goldkorn, Simona Ben-Haim
BACKGROUND: The performance of a prototype novel digital single-photon emission computed tomography (SPECT) camera with multiple pixelated CZT detectors and high sensitivity collimators (Digital SPECT; Valiance X12 prototype, Molecular Dynamics) was evaluated in various clinical settings. Images obtained in the prototype system were compared to images from an analog camera fitted with high-resolution collimators. Clinical feasibility, image quality, and diagnostic performance of the prototype were evaluated in 36 SPECT studies in 35 patients including bone (n = 21), brain (n = 5), lung perfusion (n = 3), and parathyroid (n = 3) and one study each of sentinel node and labeled white blood cells...
March 14, 2018: EJNMMI Physics
Szu-Ying Tsai, Shan-Ying Wang, Yu-Chien Shiau, Yen-Wen Wu
Hypertrophic cardiomyopathy (HCM) is an often under-diagnosed cause of left ventricular hypertrophy (LVH). It affects 1/500 of the population, is the most commonly inherited cardiovascular disorder, and can present in apical, concentric, or septal forms. Although most patients are asymptomatic, sudden cardiac death can be the initial presentation of HCM. By retrospectively enrolling patients suspected of having three different types of HCM in the absence of epicardial coronary stenosis, we aimed to examine systolic and diastolic dysfunction and perfusion abnormalities using both Doppler echocardiography and state-of-the-art gated single-photon emission computerized tomography (SPECT) myocardial perfusion imaging (MPI) with a cadmium-zinc-telluride camera and thallium-201...
March 8, 2018: Scientific Reports
Saurabh Malhotra, Rami Doukky
No abstract text is available yet for this article.
March 6, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Denis Agostini, Vincent Roule, Catherine Nganoa, Nathaniel Roth, Raphael Baavour, Jean-Jacques Parienti, Farzin Beygui, Alain Manrique
PURPOSE: We assessed the feasibility of myocardial blood flow (MBF) and flow reserve (MFR) estimation using dynamic SPECT with a novel CZT camera in patients with stable CAD, in comparison with15 O-water PET and fractional flow reserve (FFR). METHODS: Thirty patients were prospectively included and underwent FFR measurements in the main coronary arteries (LAD, LCx, RCA). A stenosis ≥50% was considered obstructive and a FFR abnormal if ≤0.8. All patients underwent a dynamic rest/stress99m Tc-sestamibi CZT-SPECT and15 O-water PET for MBF and MFR calculation...
March 1, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Scott S Hsieh, Paurakh L Rajbhandary, Norbert J Pelc
PURPOSE: Photon counting detectors using CdTe or CZT substrates are promising candidates for future CT systems but suffer from a number of non-idealities, including charge sharing and pulse pileup. By increasing the pixel size of the detector, the system can improve charge sharing characteristics at the expense of increasing pileup. The purpose of this work is to describe these considerations in the optimization of the detector pixel pitch. METHODS: The transport of x-rays through the CdTe substrate was simulated in a Monte Carlo fashion using GEANT4...
February 8, 2018: Medical Physics
Rene Nkoulou, Mathias Wolfrum, Aju P Pazhenkottil, Michael Fiechter, Ronny R Buechel, Oliver Gaemperli, Philipp A Kaufmann
BACKGROUND: Left ventricular (LV) ejection fraction (EF) during high dobutamine stress (HD) by real-time gated-SPECT myocardial perfusion imaging (MPI) on a cadmium-zinc-telluride (CZT) gamma camera was validated versus cardiac magnetic resonance imaging (CMR). METHODS AND RESULTS: After injecting 99mTc-tetrofosmin (320 MBq) in 50 patients (mean age 64 +/- 11 years), EF at rest and post-stress as well as relevant changes in EF at HD (ΔEF ≥ 5%) were assessed. CZT and CMR rest EF values yielded an excellent correlation and agreement (r = 0...
January 16, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Julien Salvadori, Yolande Petegnief, Remi Sabbah, Olivier Morel, Hatem Boulahdour, Gilles Karcher, Pierre-Yves Marie, Laetitia Imbert
This phantom-based study was aimed to determine whether cardiac CZT-cameras, which provide an enhanced spatial resolution and image contrast compared to Anger cameras, are similarly affected by small cardiac motions. Translations of a left ventricular (LV) insert at half-SPECT acquisitions through six possible orthogonal directions and with 5- or 10-mm amplitude were simulated on the Discovery NM-530c and DSPECT CZT-cameras and on an Anger Symbia T2 camera equipped with an astigmatic (IQ.SPECT) or conventional parallel-hole collimator (Conv...
January 11, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Takanaga Niimi, Mamoru Nanasato, Mitsuo Sugimoto, Hisatoshi Maeda
Purpose: The differences in performance between the cadmium-zinc-telluride (CZT) camera or collimation systems and conventional Anger single-photon emission computed tomography (A-SPECT) remain insufficient from the viewpoint of the user. We evaluated the performance of the D-SPECT (Spectrum Dynamics, Israel) system to provide more information to the cardiologist or radiological technologist about its use in the clinical field. Materials and Methods: This study evaluated the performance of the D-SPECT system in terms of energy resolution, detector sensitivity, spatial resolution, modulation transfer function (MTF), and collimator resolution in comparison with that of A-SPECT (Bright-View, Philips, Japan)...
December 2017: Nuclear Medicine and Molecular Imaging
Alessia Gimelli, Riccardo Liga, Alberto Clemente, Emilio Maria Pasanisi, Brunella Favilli, Paolo Marzullo
Aims: To evaluate the impact of diabetes mellitus (DM) on the accuracy of myocardial perfusion scintigraphy (MPS) in detecting coronary artery disease (CAD). Methods and results: Two hundred and sixteen patients with DM and 432 matched controls were submitted to MPS on a dedicated cardiac camera equipped with cadmium-zinc-telluride (CZT) detectors and coronary angiography. Exercise stress was performed in 442 (68%) patients, while the remainders underwent vasodilator stress...
December 11, 2017: European Heart Journal Cardiovascular Imaging
Shiva Abbaszadeh, Garry Chinn, Craig S Levin
The kinematics of Compton scatter can be used to estimate the interaction sequence of inter-crystal scatter interactions in 3-D position-sensitive cadmium zinc telluride (CZT) detectors. However, in the case of intra-crystal scatter in a "cross-strip" CZT detector slab, multiple anode and cathode strips may be triggered, creating position ambiguity due to uncertainty in possible combinations of anode-cathode pairings. As a consequence, methods such as energy-weighted centroid are not applicable to position the interactions...
November 13, 2017: Physics in Medicine and Biology
Yosuke Miyazaki, Yasuhiro Kato, Akira Imoto, Kazuki Fukuchi
Purpose: Cadmium zinc telluride (CZT) detectors have recently been introduced to the field of clinical nuclear cardiology. However, the feasibility of using them for organs other than the heart remains unclear. The aim of this study was to evaluate the potential of a cardiac CZT camera to acquire thyroid and parathyroid images. We used custom-made phantoms and the currently available standard protocols for CZT, instead of a sodium-iodine scintillation (NaI) camera. Materials and Methods: Thyroid phantoms with or without parathyroid adenomas were made from agar using radiopharmaceuticals ((99m)Tc or (123)I) and imaged using CZT and NaI cameras...
November 10, 2017: Journal of Nuclear Medicine Technology
Yu-Hua Dean Fang, Tzu-Pei Su, Chi-Jen Chang, Kung-Chu Ho, May Su, Tzu-Chen Yen
The purpose of this study was to investigate if a novel parameter, the stress-to-rest ratio of the signal-to-noise ratio (RSNR) obtained with a cadmium zinc telluride (CZT) SPECT scanner, could be used to distinguish triple-vessel disease (TVD) patients. Methods. One hundred and two patients with suspected coronary artery disease were retrospectively involved. Each subject underwent a Tl-201 SPECT scan and subsequent coronary angiography. Subjects were separated into TVD (n = 41) and control (n = 61) groups based on coronary angiography results using 50% as the stenosis cutoff...
2017: Contrast Media & Molecular Imaging
Alexander Mauring, Tim Vidmar, Torbjörn Gäfvert, Jon Drefvelin, Aldo Fazio
In situ gamma spectrometry is a widely applied analysis technique for the determination of radioactivity levels in soil. Compared to traditional laboratory analysis of soil samples, in situ techniques offer a quick and low-cost way of obtaining accurate results from on-site measurements. However, although the technique is well-known, the dependence of in situ gamma spectrometry on complex and time-consuming calibration procedures as well as in-depth knowledge of the geometric distribution of the source in the ground deters many potential users from employing it in their routine work...
October 23, 2017: Journal of Environmental Radioactivity
Man Zhang, Guanyong Wang, Lei Zhang
Precise azimuth-variant motion compensation (MOCO) is an essential and difficult task for high-resolution synthetic aperture radar (SAR) imagery. In conventional post-filtering approaches, residual azimuth-variant motion errors are generally compensated through a set of spatial post-filters, where the coarse-focused image is segmented into overlapped blocks concerning the azimuth-dependent residual errors. However, image domain post-filtering approaches, such as precise topography- and aperture-dependent motion compensation algorithm (PTA), have difficulty of robustness in declining, when strong motion errors are involved in the coarse-focused image...
October 26, 2017: Sensors
Alessia Gimelli, Riccardo Liga, Serena Magro, Salvatore Novo, Roberto Pedrinelli, Anna Sonia Petronio, Paolo Marzullo, Alessia Pepe
BACKGROUND: Single-photon emission computed tomography has shown relevant limitations in the quantification of left ventricular (LV) mass. We sought to compare the estimates of LV mass on Cadmium-Zinc-Telluride (CZT) myocardial perfusion imaging (MPI) as compared to cardiac magnetic resonance (CMR). METHODS AND RESULTS: Twenty-five patients underwent MPI on a CZT camera and CMR on a 1.5 T scanner within 12 ± 3 weeks. LV mass was quantified on CZT images using two softwares: 4D-MSPECT (4DM) and Emory Cardiac Toolbox (ECTb)...
October 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Noriko Tsuda, Shinya Shiraishi, Fumi Sakamoto, Hideaki Yuki, Koji Ogasawara, Morikatsu Yoshida, Seiji Tomiguchi, Kenichi Tsujita, Yasuyuki Yamashita
BACKGROUND: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disorders. The aim of this study was to examine whether the quantitatively measured myocardial blood flow (MBF) or myocardial perfusion reserve (MPR), calculated by dynamic single photon emission computed tomography (SPECT) analysis using a cardiac cadmium zinc telluride (CZT) gamma camera, was related to renal dysfunction in patients with normal myocardial perfusion imaging (MPI) findings. METHODS: The study population consisted of 46 patients with CKD and 46 individuals without CKD (controls)...
August 30, 2017: Journal of Cardiology
J D van Dijk, N M Borren, M Mouden, J A van Dalen, J P Ottervanger, P L Jager
BACKGROUND: SPECT Myocardial perfusion imaging (MPI) is associated with a relatively high radiation burden and decreasing image quality in heavy patients. Patient-specific low-activity protocols (PLAPs) are suggested but follow-up data is lacking. Our aim was to compare the use of a standard fixed-activity protocol (FAP) with a PLAP in cadmium zinc telluride (CZT)-SPECT MPI. METHODS: We retrospectively included 1255 consecutive patients who underwent CZT-SPECT stress-optional rest MPI...
August 18, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Yu-Hua Dean Fang, Yuan-Chang Liu, Kung-Chu Ho, Feng-Cheng Kuo, Ching-Fang Yang, Tzu-Chen Yen, I-Chang Hsieh
INTRODUCTION: We aimed to evaluate whether the hyperemic myocardial blood flow (MBF) can be estimated using cadmium zinc telluride (CZT)-based single-photon emission computed tomography (SPECT) cameras with a single, rapid rest/stress dynamic scan. Dynamic contrast-enhanced (DCE) cardiac magnetic resonance imaging (MRI) was used as a reference modality for flow measurement. MATERIALS AND METHODS: The proposed protocol included both the rest and stress acquisitions within a 24-min scan...
2017: PloS One
Alessia Gimelli, Riccardo Liga, Francesca Menichetti, Ezio Soldati, Maria Grazia Bongiorni, Paolo Marzullo
BACKGROUND: A correlation between left ventricular (LV) dyssynchrony (LVD) and impaired myocardial sympathetic tone has been hypothesized. We sought to assess the interactions between regional LV sympathetic innervation, perfusion, and mechanical dyssynchrony. METHODS: Eighty-three patients underwent evaluation of LV perfusion and sympathetic innervation on (99m)Tc-tetrofosmin/(123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging. The summed rest score and summed (123)I-MIBG score (SS-MIBG) were computed...
August 14, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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