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Masaru Ishihara, Yasuyo Taniguchi, Masahisa Onoguchi, Takayuki Shibutani
BACKGROUND: We aimed to determine the optimal thallium 201 chloride (thallium-201) dose using a novel ultrafast cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors (D-SPECT). METHODS AND RESULTS: The optimal thallium-201 dose for obtaining left ventricular (LV) myocardial counts was determined from a phantom study. Consecutive 292 patients underwent stress myocardial perfusion imaging with a thallium-201 injection. Stress test comprised exercise or pharmacological (adenosine) provocation...
December 22, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Michael Ljungberg, P Hendrik Pretorius
Functional nuclear medicine imaging with Single-Photon Emission Computed Tomography (SPECT) in combination with anatomical Computed Tomography (CT) has been commercially available since the beginning of this century. The combination of the two modalities has improved both sensitivity and specificity of many clinical applications and CT in conjunction with SPECT allows for spatial overlay of the SPECT data on good anatomy images. Introduction of diagnostic CT units as part of the SPECT/CT system has also potentially allowed for a more cost-efficient use of the equipment...
November 15, 2016: British Journal of Radiology
Marine Claudin, Laetitia Imbert, Wassila Djaballah, Nicolas Veran, Sylvain Poussier, Véronique Roch, Mathieu Perrin, Antoine Verger, Henri Boutley, Gilles Karcher, Pierre-Yves Marie
PURPOSE: Gamma-cameras, with Cadmium-Zinc-Telluride (CZT) detectors, allow to perform myocardial perfusion imaging (MPI) with limited injected activities and recorded times. This study aimed at determining whether the routine assessment of left ventricular (LV) function with such limited counts protocols compares well with reference values from cardiac MRI. METHODS: The study included patients who have undergone cardiac MRI and an MPI routinely planned on a CZT camera with a low-dose protocol (120 MBq of Sestamibi for stress and 360 MBq at rest for 75 kg body weight), while targeting the recording of only 500 myocardial kcounts in order to limit the recording times (<10 minutes for stress, <4 minutes for rest)...
September 27, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Denis Agostini, Pierre-Yves Marie, Simona Ben-Haim, François Rouzet, Bernard Songy, Alessandro Giordano, Alessia Gimelli, Fabien Hyafil, Roberto Sciagrà, Jan Bucerius, Hein J Verberne, Riemer H J A Slart, Oliver Lindner
The trade-off between resolution and count sensitivity dominates the performance of standard gamma cameras and dictates the need for relatively high doses of radioactivity of the used radiopharmaceuticals in order to limit image acquisition duration. The introduction of cadmium-zinc-telluride (CZT)-based cameras may overcome some of the limitations against conventional gamma cameras. CZT cameras used for the evaluation of myocardial perfusion have been shown to have a higher count sensitivity compared to conventional single photon emission computed tomography (SPECT) techniques...
December 2016: European Journal of Nuclear Medicine and Molecular Imaging
Doumit Daou, Remy Sabbah, Carlos Coaguila, Hatem Boulahdour
No abstract text is available yet for this article.
August 18, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Ronaldo Lima, Thais Peclat, Thalita Soares, Caio Ferreira, Ana Carolina Souza, Gabriel Camargo
BACKGROUND: Recent studies have shown that myocardial perfusion imaging (MPI) in cadmium-zinc-telluride (CZT) cameras allow faster exams with less radiation dose but there are little data comparing its prognosis information with that of dedicated cardiac Na-I SPECT cameras OBJECTIVE: The objective of this study is to compare the prognostic value of MPI using an ultrafast protocol with low radiation dose in a CZT-SPECT and a traditional one. METHODS: Group 1 was submitted to a two-day MIBI protocol in a conventional camera, and group 2 was submitted to a 1-day MIBI protocol in CZT camera...
August 10, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Federico Caobelli, Tim Wollenweber, Udo Bavendiek, Christian Kühn, Christian Schütze, Lilli Geworski, James T Thackeray, Johann Bauersachs, Axel Haverich, Frank M Bengel
AIMS: High-energy resolution and sensitivity of novel cadmium-zinc-telluride (CZT) detector equipped SPECT systems facilitate simultaneous imaging of multiple isotopes and may enhance the detection of molecular/cellular signals. This may refine the detection of endocarditis. This study was designed to determine the feasibility and diagnostic accuracy of simultaneous imaging of inflammation with (111)In-labeled white blood cells (WBCs) and myocardial perfusion with (99m)Tc-sestamibi, for localization of WBCs relative to the valve plane in suspected endocarditis...
July 28, 2016: European Heart Journal
John A Kennedy, H William Strauss
A solid-state cadmium zinc tellurium (CZT) dedicated multipinhole cardiac camera which acquires all views simultaneously has been introduced for myocardial SPECT acquisition. We report a method to detect and ameliorate patient motion artifacts in myocardial perfusion imaging (MPI) studies recorded with this device. To detect motion, a myocardial phantom study was recorded, and at mid-scan, the phantom was moved stepwise along each of 6 orthogonal directions, causing MPI artifacts. Using QPS software (Cedars-Sinai) and an in-house normal database, displacements giving artifactual perfusion defects (total perfusion deficit score, TPD, >5 %) were all 1...
July 14, 2016: Medical & Biological Engineering & Computing
Joris D van Dijk, Jorn A van Dalen, Mohamed Mouden, Jan Paul Ottervanger, Siert Knollema, Cornelis H Slump, Pieter L Jager
BACKGROUND: Correction of motion has become feasible on cadmium-zinc-telluride (CZT)-based SPECT cameras during myocardial perfusion imaging (MPI). Our aim was to quantify the motion and to determine the value of automatic correction using commercially available software. METHODS AND RESULTS: We retrospectively included 83 consecutive patients who underwent stress-rest MPI CZT-SPECT and invasive fractional flow reserve (FFR) measurement. Eight-minute stress acquisitions were reformatted into 1...
July 12, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Rene Nkoulou, Tobias A Fuchs, Aju P Pazhenkottil, Silke M Kuest, Jelena R Ghadri, Julia Stehli, Michael Fiechter, Bernhard A Herzog, Oliver Gaemperli, Ronny R Buechel, Philipp A Kaufmann
: Recent advances in SPECT technology including cadmium-zinc-telluride (CZT) semiconductor detector material may pave the way for absolute myocardial blood flow (MBF) measurements by SPECT. The aim of the present study was to compare K1 uptake rate constants as surrogates of absolute MBF and myocardial flow reserve index (MFRi) in humans as assessed with a CZT SPECT camera versus PET. METHODS: Absolute MBF was assessed in 28 consecutive patients undergoing adenosine stress-rest myocardial perfusion imaging (MPI) by (99m)Tc-tetrofosmin CZT SPECT and (13)N-ammonia PET, and MFR was calculated as a ratio of hyperemic over resting MBF...
December 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Vladimír Kincl, Milan Kamínek, Jiří Vašina, Roman Panovský, Martin Havel
High efficiency cadmium-zinc-telluride (CZT) cameras provide an opportunity to lower the injected activities of radiopharmaceuticals for single photon emission tomography (SPECT) myocardial perfusion imaging (MPI). The limits for reducing activities of thallium have not been determined, particularly in obese patients. After an injection of 0.7 megabecquerel (MBq) of thallium/kg, we collected an average 1.5 million counts for the 10-min acquisition in a pilot cohort of ten patients. After extrapolation, we reduced the administered activity to 0...
September 2016: International Journal of Cardiovascular Imaging
Zhaoheng Xie, Suying Li, Kun Yang, Baixuan Xu, Qiushi Ren
In this paper, we propose a wobbling method to correct bad pixels in cadmium zinc telluride (CZT) detectors, using information of related images. We build up an automated device that realizes the wobbling correction for small animal Single Photon Emission Computed Tomography (SPECT) imaging. The wobbling correction method is applied to various constellations of defective pixels. The corrected images are compared with the results of conventional interpolation method, and the correction effectiveness is evaluated quantitatively using the factor of peak signal-to-noise ratio (PSNR) and structural similarity (SSIM)...
2016: Sensors
Simona Ben-Haim, John Kennedy, Zohar Keidar
Myocardial perfusion imaging plays an important role in the assessment of patients with known or suspected coronary artery disease and is well established for diagnosis and for prognostic evaluation in these patients. The dedicated cardiac SPECT cameras with solid-state cadmium zinc telluride (CZT) detectors were first introduced a decade ago. A large body of evidence is building up, showing the superiority of the new technology compared with conventional gamma cameras. Not only the CZT detectors, but also new collimator geometries, the ability to perform focused imaging optimized for the heart and advances in data processing algorithms all contribute to the significantly improved sensitivity up to 8-10 times, as well as improved energy resolution and improved reconstructed spatial resolution compared with conventional technology...
July 2016: Seminars in Nuclear Medicine
Emmanuel D'estanque, Christophe Hedon, Benoît Lattuca, Aurélie Bourdon, Meriem Benkiran, Aurélie Verd, François Roubille, Denis Mariano-Goulart
BACKGROUND: Dual-isotope (201)Tl/(123)I-MIBG SPECT can assess trigger zones (dysfunctions in the autonomic nervous system located in areas of viable myocardium) that are substrate for ventricular arrhythmias after STEMI. This study evaluated the necessity of delayed acquisition and scatter correction for dual-isotope (201)Tl/(123)I-MIBG SPECT studies with a CZT camera to identify trigger zones after revascularization in patients with STEMI in routine clinical settings. METHODS: Sixty-nine patients were prospectively enrolled after revascularization to undergo (201)Tl/(123)I-MIBG SPECT using a CZT camera (Discovery NM 530c, GE)...
May 25, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Doumit Daou, Rémy Sabbah, Carlos Coaguila, Hatem Boulahdour
BACKGROUND: We developed a data-driven respiratory motion (RM) correction method (REGAT program) for multiple-pinhole detector CZT SPECT. We verified its clinical feasibility with myocardial perfusion imaging (MPI) and studied its impact on image characteristics. METHODS: This retrospective study included 18 patients having stress/rest (99m)Tc-Tetrofosmin MPI SPECT. List mode was acquired on CZT SPECT and processed with REGAT. REGAT generates reconstructed RM-gated volumes that are summed either without realignment (NR-SPECT) or after realignment (R-SPECT)...
May 11, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Alban Bailliez, Olivier Lairez, Charles Merlin, Nicolas Piriou, Damien Legallois, Tanguy Blaire, Denis Agostini, Frederic Valette, Alain Manrique
UNLABELLED: This study compared two SPECT cameras with cadmium-zinc-telluride (CZT) detectors to a conventional Anger camera with cardiofocal collimators for the assessment of left ventricular (LV) function in a phantom and patients. METHODS: A gated dynamic cardiac phantom was used. Eighteen acquisitions were processed on each CZT camera and the conventional camera. The total number of counts within a myocardial volume of interest varied from 0.25 kcts to 1.5 Mcts...
September 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Kuan-Yin Ko, Yen-Wen Wu, Chia-Ju Liu, Mei-Fang Cheng, Ruoh-Fang Yen, Kai-Yuan Tzen
OBJECTIVE: Identification of right ventricular (RV) abnormalities is important in patients with suspected coronary artery disease (CAD). RV activity can be better visualized on myocardial single-photon emission computerized tomography (SPECT) using a higher sensitivity cadmium-zinc-telluride (CZT) detector. The aim of this study was to investigate the clinical significance of RV/left ventricular (LV) uptake ratios during exercise thallium-201 SPECT using CZT detectors. PATIENTS AND METHODS: A total of 102 patients underwent treadmill ECG-gated SPECT, coronary angiography, and echocardiography...
June 2016: Nuclear Medicine Communications
Jing Wu, Shu-Fei Lin, Jean-Dominique Gallezot, Chung Chan, Rameshwar Prasad, Stephanie L Thorn, Mitchel R Stacy, Yiyun Huang, Taraneh Hashemi Zonouz, Yi-Hwa Liu, Rachel J Lampert, Richard E Carson, Albert J Sinusas, Chi Liu
UNLABELLED: Conventional 2-dimensional planar imaging of (123)I-metaiodobenzylguanidine ((123)I-mIBG) is not fully quantitative. To develop a more accurate quantitative imaging approach, we investigated dynamic SPECT imaging with kinetic modeling in healthy humans to obtain the myocardial volume of distribution (VT) for (123)I-mIBG. METHODS: Twelve healthy humans underwent 5 serial 15-min SPECT scans at 0, 15, 90, 120, and 180 min after bolus injection of (123)I-mIBG on a hybrid cadmium zinc telluride SPECT/CT system...
August 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Taishiro Chikamori, Satoshi Hida, Nobuhiro Tanaka, Yuko Igarashi, Jun Yamashita, Chie Shiba, Naotaka Murata, Kou Hoshino, Yohei Hokama, Akira Yamashina
BACKGROUND: Although stress single-photon emission computed tomography (SPECT) using a cadmium-zinc-telluride (CZT) camera facilitates radiation dose reduction, only a few studies have evaluated its diagnostic accuracy in Japanese patients by applying fractional flow reserve (FFR) measurements. METHODS AND RESULTS: We prospectively evaluated 102 consecutive patients with suspected or known coronary artery disease with a low-dose stress/rest protocol ((99m)Tc radiotracer 185/370 MBq) using CZT SPECT...
April 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
Taishiro Chikamori, Kenji Goto, Satoshi Hida, Masao Miyagawa, Hayato Ishimura, Kenji Uchida, Takaya Fukuyama, Teruhito Mochizuki, Akira Yamashina
BACKGROUND: Despite the introduction of the novel cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) in Japan; its diagnostic value in clinical practice remains largely unknown. METHODS: The Semiconductor SPECT Study group is a multicenter Japanese registry which registered 1000 patients to evaluate the diagnostic utility of the CZT camera system (Discovery NM530c; GE Healthcare, Haifa, Israel). The patients underwent stress myocardial SPECT and coronary angiography within a 3-month interval...
February 2017: Journal of Cardiology
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