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Contralateral prophylactic mastectomy

J V Hegde, J Wang, A Kusske, S A McCloskey
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Kalatu R Davies, Abenaa M Brewster, Isabelle Bedrosian, Patricia A Parker, Melissa A Crosby, Susan K Peterson, Yu Shen, Robert J Volk, Scott B Cantor
BACKGROUND: Family history of breast cancer is associated with an increased risk of contralateral breast cancer (CBC) even in the absence of mutations in the breast cancer susceptibility genes BRCA1/2. We compared quality-adjusted survival after contralateral prophylactic mastectomy (CPM) with surveillance only (no CPM) among women with breast cancer incorporating the degree of family history. METHODS: We created a microsimulation model for women with first-degree, second-degree, and no family history treated for a stage I, II, or III estrogen receptor (ER)-positive or ER-negative breast cancer at the ages of 40, 50, 60, and 70...
2016: Breast Cancer Research: BCR
Lotte E Elshof, Michael Schaapveld, Marjanka K Schmidt, Emiel J Rutgers, Flora E van Leeuwen, Jelle Wesseling
PURPOSE: To assess the effect of different treatment strategies on the risk of subsequent invasive breast cancer (IBC) in women diagnosed with ductal carcinoma in situ (DCIS). METHODS: Up to 15-year cumulative incidences of ipsilateral IBC (iIBC) and contralateral IBC (cIBC) were assessed among a population-based cohort of 10,090 women treated for DCIS in the Netherlands between 1989 and 2004. Multivariable Cox regression analyses were used to evaluate associations of treatment with iIBC risk...
October 2016: Breast Cancer Research and Treatment
Anita Mamtani, Monica Morrow
Breast-conserving therapy (BCT) and mastectomy result in equivalent longterm survival. Locoregional recurrence rates after BCT have decreased over time and are now similar to those after mastectomy. Contralateral breast cancer rates are declining as well owing to the widespread use of adjuvant systemic therapy. Despite these improved outcomes, increasing rates of bilateral mastectomy for unilateral cancer have been observed in the United States. Medical indications for mastectomy are well defined and present in a minority of patients, and women at increased risk for contralateral cancer are a small proportion of the breast cancer population...
August 26, 2016: Annual Review of Medicine
Michael S Sabel, Casey T Kraft, Kent A Griffith, Jessica M Bensenhaver, Lisa A Newman, Sarah T Hawley, Adeyiza O Momoh
There has been an increasing use of bilateral mastectomy (BM) for breast cancer. We sought to examine our trends among breast conservation (BCT) candidates and women recommended for unilateral mastectomy (UM). Our prospective breast cancer database was queried for women with a first-time, unilateral breast cancer. Patient and histologic factors and surgical treatment, including reconstruction, were evaluated. A detailed chart review was performed among patients from two representative time periods as to the reasons the patient underwent mastectomy...
August 26, 2016: Breast Journal
Tina J Hieken, Judy C Boughey
No abstract text is available yet for this article.
August 2016: Gland Surgery
Jonathan Walter Esclovon, Melissa Ponder, Nail Aydin, Subhasis Misra
A 59-year-old woman with right breast mass was diagnosed with invasive ductal carcinoma (IDC). Workup consisted of bilateral diagnostic mammogram and ultrasound (US); both showed a right breast mass with normal left breast. Core biopsy showed IDC with estrogen receptor negative (ER-)/progesterone receptor negative (PR-) and HER2/neu positive receptor status. The patient underwent carboplatin-based chemotherapy with Herceptin. The mass completely resolved. The patient desired to proceed with bilateral total mastectomy with right sentinel lymph node biopsy (SLNB)...
August 18, 2016: BMJ Case Reports
Stephanie Tesson, Imogen Richards, David Porter, Kelly-Anne Phillips, Nicole Rankin, Toni Musiello, Michelle Marven, Phyllis Butow
OBJECTIVE: Most women diagnosed with unilateral breast cancer without BRCA1 or BRCA2 mutations are at low risk of contralateral breast cancer. Contralateral Prophylactic Mastectomy (CPM) decreases the relative risk of contralateral breast cancer, but may not increase life expectancy; yet international uptake is increasing. This study applied protection motivation theory (PMT) to determine factors associated with women's intentions to undergo CPM. METHODS: Three hundred eighty-eight women previously diagnosed with unilateral breast cancer and of negative or unknown BRCA1 or BRCA2 status were recruited from an advocacy group's research database...
May 2016: Patient Education and Counseling
Frederick L Moffat, Danny Yakoub
The purpose of this study is to assess the consequences for breast cancer patients of the trend away from breast conservation in favor of bilateral and contralateral mastectomy. The methods are followed from the review of the literature from 1991 to 2015. Breast-conserving surgery and sentinel lymph node biopsy, introduced into mainstream practice in the 1980s and 1990s, respectively, are now the standard of care for early-stage breast cancer. Disruptive change has unexpectedly supervened in the guise of bilateral mastectomy for cancer or prophylaxis and contralateral prophylactic mastectomy...
August 2016: Breast Cancer Research and Treatment
Judy C Boughey, Deanna J Attai, Steven L Chen, Hiram S Cody, Jill R Dietz, Sheldon M Feldman, Caprice C Greenberg, Rena B Kass, Jeffrey Landercasper, Valerie Lemaine, Fiona MacNeill, Julie A Margenthaler, David H Song, Alicia C Staley, Lee G Wilke, Shawna C Willey, Katharine A Yao
No abstract text is available yet for this article.
October 2016: Annals of Surgical Oncology
Judy C Boughey, Deanna J Attai, Steven L Chen, Hiram S Cody, Jill R Dietz, Sheldon M Feldman, Caprice C Greenberg, Rena B Kass, Jeffrey Landercasper, Valerie Lemaine, Fiona MacNeill, David H Song, Alicia C Staley, Lee G Wilke, Shawna C Willey, Katharine A Yao, Julie A Margenthaler
No abstract text is available yet for this article.
October 2016: Annals of Surgical Oncology
Maria K Venetis, Erina L MacGeorge, Dadrie F Baptiste, Ashton Mouton, Lorin B Friley, Rebekah Pastor, Kristen Hatten, Janaka Lagoo, Monet W Bowling, Susan E Clare
OBJECTIVES: The rate of contralateral prophylactic mastectomy (CPM) has risen sharply in the past decade. The current study was designed to examine social network, surgeon, and media influence on patients' CPM decision-making, examining not only who influenced the decision, and to what extent, but also the type of influence exerted. METHODS: Patients (N=113) who underwent CPM at 4 Indiana University-affiliated hospitals between 2008 and 2012 completed structured telephone interviews in 2013...
July 26, 2016: American Journal of Clinical Oncology
J R Benson, Z E Winters
No abstract text is available yet for this article.
September 2016: British Journal of Surgery
Katharine Yao, Mark Sisco, Isabelle Bedrosian
There has been an increasing trend in the use of contralateral prophylactic mastectomy (CPM) in the United States among women diagnosed with unilateral breast cancer, particularly young women. Approximately one-third of women <40 years old are undergoing CPM in the US. Most studies have shown that the CPM trend is mainly patient-driven, which reflects a changing environment for newly diagnosed breast cancer patients. The most common reason that women choose CPM is based on misperceptions about CPM's effect on survival and overestimation of their contralateral breast cancer (CBC) risk...
2016: International Journal of Women's Health
Brittany L Murphy, Tanya L Hoskin, Judy C Boughey, Amy C Degnim, Katrina N Glazebrook, Tina J Hieken
BACKGROUND: The use of contralateral prophylactic mastectomy (CPM) for women with unilateral breast cancer is increasing. The authors were interested in assessing whether this trend extended to patients with T4 disease. METHODS: We identified 92 patients from our prospective breast surgery registry with unilateral clinical T4 M0 disease who underwent mastectomy at our institution from October 2008 to July 2015. Patient, tumor, and treatment variables were compared between patients who did and those who did not undergo CPM, and the reasons patients elected CPM were ascertained...
October 2016: Annals of Surgical Oncology
Adeyiza O Momoh, Wess A Cohen, Kelley M Kidwell, Jennifer B Hamill, Ji Qi, Andrea L Pusic, Edwin G Wilkins, Evan Matros
OBJECTIVE: Assess postoperative morbidity and patient-reported outcomes after unilateral and bilateral breast reconstruction in patients with unilateral breast cancer. BACKGROUND: Relatively little is known about the morbidity associated with and changes in quality of life experienced by patients who undergo contralateral prophylactic mastectomy (CPM) and breast reconstruction. This information would be valuable for decision making in patients with unilateral breast cancer...
June 28, 2016: Annals of Surgery
Patrick J Buchanan, Mariam Abdulghani, Jennifer F Waljee, Jeffrey H Kozlow, Michael S Sabel, Lisa A Newman, Kevin C Chung, Adeyiza O Momoh
BACKGROUND: Little is known about the role breast reconstruction plays in decisions made for contralateral prophylactic mastectomy. This study explores factors critical to patient medical decision-making for contralateral prophylactic mastectomy and reconstruction among women with early stage, unilateral breast cancer. METHODS: A mixed methods approach was used to gain an understanding of patients' choices and experiences. Patients with stage 0 to III unilateral breast cancer who underwent reconstruction were recruited, and semistructured interviews were conducted...
July 2016: Plastic and Reconstructive Surgery
Alessandro Fancellu
Rates of mastectomy and contralateral prophylactic mastectomy (CPM) are increasing in patients with unilateral breast cancer who would be candidates for receiving breast-conserving surgery, according to recent studies. One reason for this finding is the entitlement of patients to choose to undergo a bilateral mastectomy as a surgery option. The present case report details the case of a 52-year-old woman, eligible for breast conservation, who had no high risk of developing a contralateral breast cancer, but who asked for a bilateral mastectomy and immediate reconstruction instead of breast-conserving surgery...
July 2016: Oncology Letters
Amanda Roberts, Lakhbir Sandhu, Tulin D Cil, Stefan O P Hofer, Toni Zhong
AIM: To examine trends of contralateral prophylactic mastectomy (CPM) rates at a Canadian academic breast cancer center. METHODS: A single-institution retrospective cohort study was completed. Women of any age who underwent at least a unilateral mastectomy (UM) for primary unilateral breast carcinoma between January 1, 2004 and December 31, 2010 were included. Patients who underwent CPM on the same day as UM were isolated to create two distinct cohorts. Patient and procedure characteristics were compared across groups using R software (version 3...
June 10, 2016: World Journal of Clinical Oncology
Shoshana M Rosenberg, Tari A King
No abstract text is available yet for this article.
June 2016: Gland Surgery
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