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https://www.readbyqxmd.com/read/29786075/tp53-gain-of-function-mutation-promotes-inflammation-in-glioblastoma
#1
Seok Won Ham, Hee-Young Jeon, Xiong Jin, Eun-Jung Kim, Jun-Kyum Kim, Yong Jae Shin, Yeri Lee, Se Hoon Kim, Seon Yong Lee, Sunyoung Seo, Min Gi Park, Hye-Mi Kim, Do-Hyun Nam, Hyunggee Kim
Glioblastoma (GBM), the most severe and common brain tumor in adults, is characterized by multiple somatic mutations and aberrant activation of inflammatory responses. Immune cell infiltration and subsequent inflammation cause tumor growth and resistance to therapy. Somatic loss-of-function mutations in the gene encoding tumor suppressor protein p53 (TP53) are frequently observed in various cancers. However, numerous studies suggest that TP53 regulates malignant phenotypes by gain-of-function (GOF) mutations...
May 21, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29783000/controlling-nutritional-status-score-a-promising-prognostic-marker-in-patients-with-gastrointestinal-cancers-after-surgery-a-systematic-review-and-meta-analysis
#2
REVIEW
Yi Zhang, Xu Zhang
BACKGROUND: Controlling nutritional status (CONUT) score has been reported to correlate with gastrointestinal (GI) cancer prognosis, but the results remain inconsistent. This study was to synthetically determine the associations between CONUT score and prognosis in GI cancers. METHODS: Online databases PubMed, Web of Science, Cochrane library, Embase, Google scholar, Wanfang and National Knowledge Infrastructure (CNKI) were searched for eligible articles published prior to March 10, 2018...
May 18, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29779363/prognostic-factors-affecting-surgical-outcomes-in-squamous-cell-carcinoma-of-external-auditory-canal
#3
Gi-Sung Nam, In Seok Moon, Ji Hyung Kim, Sung Huhn Kim, Jae Young Choi, Eun Jin Son
Objectives: Carcinomas of the external auditory canal (EAC) are rare, and management remains challenging. Previous studies seeking prognostic factors for EAC cancers included cancers other than carcinomas. In this study, we analyzed the treatment outcomes of, prognostic factors for, and survival rates associated with specifically squamous cell carcinoma (SCC) of the EAC. Methods: A retrospective review of 26 consecutive patients diagnosed with SCCs of the EAC in a 10-year period was performed in terms of clinical presentation, stage, choice of surgical procedure, and adjunct therapy...
May 22, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29777454/improved-outcomes-in-394-pancreatic-cancer-resections-the-impact-of-enhanced-recovery-pathway
#4
Vandana Agarwal, Martin Jose Thomas, Riddhi Joshi, Vikram Chaudhari, Manish Bhandare, Abhishek Mitra, Ashwin deSouza, Reshma Ambulkar, Shailesh V Shrikhande
BACKGROUND: Enhanced recovery (ER) pathway reduces morbidity and accelerates recovery. It is associated with reduced postoperative stay, morbidity, and costs. Feasibility and safety of ER programme has not been studied in developing countries. The objectives were to assess compliance with Enhanced Recovery After Surgery (ERAS) elements and to assess outcomes in pancreatic surgery. METHODS: Prospective study conducted from February 2014 to December 2016, following elective pancreatic cancer surgery...
May 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29771007/dichlorophenylacrylonitriles-as-ahr-ligands-displaying-selective-breast-cancer-cytotoxicity-in-vitro
#5
Jennifer R Baker, Jayne Gilbert, Stefan Paula, Xiao Zhu, Jennette A Sakoff, Adam McCluskey
Knoevenagel condensation of 3,4-dichloro- and 2,6-dichloro- phenylacetonitriles gave a library of dichlorophenylacrylonitriles. Our leads 5 and 6 displayed 0.56±0.03 and 0.127±0.04 μM growth inhibition (GI₅₀) and 260-fold selectivity for the MCF-7 breast cancer cell line. A 2,6-dichlorophenyl moiety saw a 10-fold potency loss; additional nitrogen moieties (-NO₂) enhanced activity (26 and 27), with the corresponding -NH₂ analogues (29 and 30) more potent. Despite this, both 29 (2.8±0.03 μM) and 30 (2...
May 17, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29765046/estrogen-related-receptor-gamma-functions-as-a-tumor-suppressor-in-gastric-cancer
#6
Myoung-Hee Kang, Hyunji Choi, Masanobu Oshima, Jae-Ho Cheong, Seokho Kim, Jung Hoon Lee, Young Soo Park, Hueng-Sik Choi, Mi-Na Kweon, Chan-Gi Pack, Ju-Seog Lee, Gordon B Mills, Seung-Jae Myung, Yun-Yong Park
The principle factors underlying gastric cancer (GC) development and outcomes are not well characterized resulting in a paucity of validated therapeutic targets. To identify potential molecular targets, we analyze gene expression data from GC patients and identify the nuclear receptor ESRRG as a candidate tumor suppressor. ESRRG expression is decreased in GC and is a predictor of a poor clinical outcome. Importantly, ESRRG suppresses GC cell growth and tumorigenesis. Gene expression profiling suggests that ESRRG antagonizes Wnt signaling via the suppression of TCF4/LEF1 binding to the CCND1 promoter...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29764692/combined-high-dose-rate-brachytherapy-and-external-beam-radiotherapy-for-clinically-localised-prostate-cancer
#7
Iosif Strouthos, Georgios Chatzikonstantinou, Nikolaos Zamboglou, Natasa Milickovic, Sokratis Papaioannou, Dimitra Bon, Constantinos Zamboglou, Claus Rödel, Dimos Baltas, Nikolaos Tselis
PURPOSE: To report the clinical outcomes and treatment-related toxicities after combined high-dose-rate (HDR) brachytherapy (BRT) with external beam radiotherapy (EBRT) for patients with clinically localised high-risk prostate cancer. MATERIAL AND METHODS: Between 2008 and 2012, three hundred and three consecutive patients with organ-confined high-risk prostate cancer were treated with definitive radiotherapy consisting of HDR-BRT followed by supplemental EBRT. The transrectal 3D-ultrasound-based HDR-BRT boost consisted of two single-fraction implants of 10...
May 12, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29758192/gastric-mucosal-metastasis-of-prostate-cancer
#8
Hayretdin Koklu, Gokhan Gedikoglu, Taylan Kav
A 65-year-old male patient who had been hospitalized in the ıntensive care unit for pneumonia presented with hematemesis and melena. He was diagnosed with metastatic adenocarcinoma of prostate (multiple bone and lung metastases), which was accompanied by diabetes mellitus, hypertension, and coronary heart disease. The hemoglobin levels decreased from 11.4 g/dL to 7.3 g/dL during follow-up. Upper endoscopy revealed widespread distribution of numerous umbilicated nodules with varying sizes (from 0.5 to 2 cm) on gastric mucosa (A, B, C)...
May 11, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29757147/analysis-of-weight-changes-after-left-gastric-artery-embolization-in-a-cancer-naive-population
#9
David J Kim, Hari S Raman, Amber Salter, Raja Ramaswamy, Andrew J Gunn, Clifford R Weiss, Olaguoke Akinwande
PURPOSE: We aimed to evaluate weight changes after left gastric artery (LGA) embolization in a retrospective cancer-naive cohort. METHODS: A retrospective study was conducted to identify patients who underwent LGA embolization for gastrointestinal bleeding (GI). Patients with known cancer diagnoses at the time of LGA embolization were excluded. Pre- and postprocedure weights were assessed. Statistical analysis was performed using paired t-test and Wilcoxon signed-rank test...
March 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29748836/simulation-study-of-dosimetric-effect-in-proton-beam-therapy-using-concomitant-boost-technique-for-unresectable-pancreatic-cancers
#10
Nobuyoshi Fukumitsu, Toshiyuki Okumura, Yuichi Hiroshima, Toshiki Ishida, Haruko Numajiri, Keiko Nemoto Murofushi, Kayoko Ohnishi, Teruhito Aihara, Hitoshi Ishikawa, Koji Tsuboi, Hideyuki Sakurai
PURPOSE: The purpose of this study is to investigate the dose distribution of proton beam therapy (PBT) using a concomitant boost technique for unresectable pancreatic cancers. MATERIALS AND METHODS: This simulation study involved 36 patients with unresectable pancreatic cancer. The irradiation dose was set as 67.5 gray equivalent (GyE) with 25 fractions using concomitant boost technique. The irradiation dose was set as 50 GyE to cover the whole target and another posterior beam of 17...
May 10, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29748830/-give-me-five-ultra-hypofractionated-radiotherapy-for-localized-prostate-cancer-non-invasive-ablative-approach
#11
Giulia Marvaso, Giulia Riva, Delia Ciardo, Sara Gandini, Cristiana Fodor, Dario Zerini, Sarah Pia Colangione, Giorgia Timon, Stefania Comi, Raffaella Cambria, Federica Cattani, Ottavio De Cobelli, Roberto Orecchia, Barbara A Jereczek-Fossa
Ultra-hypofractionated radiotherapy (RT) is given over a shorter time with larger doses with respect to conventional fractionation in patients with localized prostate cancer (PCa). The use of hypofractionation is supported both from the radiobiological point of view (the low α/β-ratio in PCa and dose escalation) and from the rising number of clinical evidences. The aim of this study is to review our data regarding oncological outcomes, namely biochemical progression-free survival (b-PFS) and clinical progression-free survival (c-PFS), acute and long-term toxicities in patients treated with a ultra-hypofractionated RT...
May 10, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29746336/resection-of-the-primary-gastrointestinal-neuroendocrine-tumor-improves-survival-with-or-without-liver-treatment
#12
Aaron Lewis, Mustafa Raoof, Philip H G Ituarte, John Williams, Laleh Melstrom, Daneng Li, Byrne Lee, Gagandeep Singh
OBJECTIVE: The aim of this study was to determine outcomes of primary tumor resection in metastatic neuroendocrine tumors across all primary tumor sites. BACKGROUND: Primary tumor resection (PTR) may offer a survival benefit in metastatic gastrointestinal neuroendocrine tumors (GI-NETs); however, few studies have examined the effect of primary site and grade on resection and survival. METHODS: This is a retrospective study of patients with metastatic GI-NETs at presentation between 2005 and 2011 using the California Cancer Registry (CCR) dataset merged with California Office of Statewide Health Planning and Development (OSHPD) inpatient longitudinal database...
May 9, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29746230/safety-of-programmed-death-1-pathway-inhibitors-among-patients-with-non-small-cell-lung-cancer-and-preexisting-autoimmune-disorders
#13
Giulia C Leonardi, Justin F Gainor, Mehmet Altan, Sasha Kravets, Suzanne E Dahlberg, Lydia Gedmintas, Roxana Azimi, Hira Rizvi, Jonathan W Riess, Matthew D Hellmann, Mark M Awad
Purpose Although programmed death (PD)-1 pathway inhibitors are now used in nearly all patients with advanced non-small-cell lung cancer (NSCLC), the large number of patients with NSCLC and concurrent autoimmune disease (AID) have been universally excluded from immunotherapy clinical trials. Therefore, the safety of PD-1 and PD-ligand 1 (PD-L1) inhibitors in patients with NSCLC and underlying AID is currently unknown. Methods As part of a multi-institutional effort, we retrospectively collected clinicopathologic data from patients with NSCLC and a history of AID who received monotherapy with either a PD-1 or a PD-L1 (herein referred to as PD-[L]1) inhibitor...
May 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29736307/a-novel-5t4-targeting-antibody-drug-conjugate-h6-dm4-exhibits-potent-therapeutic-efficacy-in-gastrointestinal-tumor-xenograft-models
#14
Ruixue Wang, Qinhuai Lai, Liangze Tang, Yiran Tao, Yuqin Yao, Yu Liu, Ying Lu, Chaoyong Shen, Ran Lu, Chuanwen Fan, Ruirui Zhang, Yuxi Wang, Lin Yu, Tinghan Yang, Yangping Wu, Yujia Peng, Xian Wei, Yuyin Fu, Weirong Lai, Lantu Gou, Jinliang Yang
5T4, also named as trophoblast glycoprotein, is often upregulated in some cancer cells. Here, we demonstrated that 5T4 was highly expressed in gastric, colorectal, and pancreatic cancer, associated with significantly poor prognosis of gastrointestinal (GI) cancer patients. To search for new targeting drugs for GI cancer, we developed a novel anti-5T4 monoclonal antibody with high affinity and robust internalization ability and conjugated it to the potent microtubule inhibitor DM4 to produce conjugate H6-DM4...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29734483/role-of-dynamic-contrast-enhanced-mri-in-evaluating-the-association-between-contralateral-parenchymal-enhancement-and-survival-outcome-in-er-positive-her2-negative-node-negative-invasive-breast-cancer
#15
Gi Won Shin, Yang Zhang, Min Jung Kim, Min-Ying Su, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park
BACKGROUND: Background parenchymal enhancement (BPE) on dynamic contrast-enhanced (DCE)-MRI has been associated with breast cancer risk, both based on qualitative and quantitative assessments. PURPOSE: To investigate whether BPE of the contralateral breast on preoperative DCE-MRI is associated with therapy outcome in ER-positive, HER2-negative, node-negative invasive breast cancer. STUDY TYPE: Retrospective. POPULATION: In all, 289 patients with unilateral ER-positive, HER2-negative, node-negative breast cancer larger than 5 mm...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29730783/tissue-indices-of-telomere-length-and-p53-in-patients-with-different-gastrointestinal-tumors-correlation-with-clinicopathological-status
#16
Hala M ElBadre, Reham I El-Mahdy, Nahed A Mohamed, Madeha M Zakhary, Doaa W Maximous
Telomere length dysfunction is involved in the generation of genomic rearrangements that drive progression to malignancy. A set of serological markers for telomere dysfunction, namely chitinase and N-acetylglucosaminidase (NAG), DNA damage, and tissue alteration of p53 have been identified. The probability that genomic damage, accumulation of reactive oxygen species, and shorter telomeres may be related to the onset and advancement of gastrointestinal (GI) tumors. A total of 40 patients with GI tumors and 20 healthy controls with matched age and sex were included...
May 5, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29715156/elevated-neutrophil-to-lymphocyte-ratio-predicts-survival-in-patients-with-advanced-gastric-cancer-treated-with-trastuzumab-combination-chemotherapy
#17
Gi Yong Hwang, Dong Won Baek, Hee Jeong Cho, Soo Jung Lee, Yee Soo Chae, Byung Woog Kang, In Hee Lee, Jong Gwang Kim, An Na Seo, Han Ik Bae, Ki Bum Park, Ji Yeon Park, Oh Kyoung Kwon, Seung Soo Lee, Ho Young Chung
BACKGROUND/AIM: This study investigated the clinical prognostic relevance of the neutrophil-to-lymphocyte ratio (NLR) in patients with human epidermal receptor 2 (HER2)-positive metastatic advanced gastric cancer (AGC) treated with combination chemotherapy including trastuzumab. PATIENTS AND METHODS: This is a retrospective analysis of 73 patients diagnosed with metastatic AGC who were treated with trastuzumab combination chemotherapy. NLR was calculated as the neutrophil count divided by the lymphocyte count...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29713678/step-up-training-for-colorectal-and-gastric-esd-and-the-challenge-of-esd-training-in-the-proximal-colon-results-from-a-german-center
#18
Alanna Ebigbo, Andreas Probst, Christoph Römmele, Helmut Messmann
Background and study aims: The endoscopic submucosal dissection (ESD) of cancerous and precancerous lesions in the gastrointestinal (GI) tract is an effective but difficult-to-learn procedure, especially for Western endoscopists. We developed a step-up training protocol and evaluated its outcome on a single endoscopist using specific performance measures. Patients and methods: The training protocol included a 12-month period of 50 observational and supervised ESD cases as well as 24 animal procedures...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29709909/induction-of-apoptosis-by-citrus-unshiu-peel-in-human-breast-cancer-mcf-7-cells-involvement-of-ros-dependent-activation-of-ampk
#19
Min Yeong Kim, Hyun Hwang Bo, Eun Ok Choi, Da He Kwon, Hong Jae Kim, Kyu Im Ahn, Seon Yeong Ji, Jin-Woo Jeong, Shin-Hyung Park, Su-Hyun Hong, Gi-Young Kim, Cheol Park, Heui-Soo Kim, Sung-Kwon Moon, Seok-Joong Yun, Wun Jae Kim, Yung Hyun Choi
The fruit of Citrus unshiu MARKOVICH used for various purposes in traditional medicine has various pharmacological properties including antioxidant, anti-inflammatory, and antibacterial effects. Recently, the possibility of anti-cancer activity of the extracts or components of this fruit has been reported; however, the exact mechanism has not yet been fully understood. In this study, we evaluated the anti-proliferative effect of water extract of C. unshiu peel (WECU) on human breast cancer MCF-7 cells and investigated the underlying mechanism...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29705628/gastrointestinal-cancer-incidence-in-type-2-diabetes-mellitus-results-from-a-large-population-based-cohort-study-in-the-uk
#20
Roy G P J de Jong, Paul J H L Peeters, Andrea M Burden, Marie L de Bruin, Harm R Haak, Ad A M Masclee, Frank de Vries, Maryska L G Janssen-Heijnen
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) have been shown to have higher incidences of liver, pancreatic, and colorectal cancer compared to non-diabetic individuals. Current evidence is conflicting for other gastrointestinal (GI) cancers. Therefore, we aimed to determine incidence rates (IRs) of all GI cancers in patients with and without T2DM. METHODS: A cohort study was performed using the UK Clinical Practice Research Datalink (1988-2012). A cohort of antidiabetic drug users was matched at baseline to a non-diabetic cohort, by age, sex, and practice...
April 26, 2018: Cancer Epidemiology
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