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https://www.readbyqxmd.com/read/29779300/coroners-recommendations-for-prevention-of-resident-deaths-in-aged-care-the-role-of-primary-care-providers
#1
Georgia Aitken, Athena Demosthenous, Lyndal Bugeja, Melissa Willoughby, Carmel Young, Joseph E Ibrahim
BACKGROUND AND OBJECTIVES: Currently, very little is known about how coroners consider a role for general practitioners (GPs) and registered nurses (RNs) in recommendations for the prevention of premature death. Involving these professions in recommendations generally directed towards government organisations or residential aged care providers and management may contribute to more successful broader policy changes. The aim of this article was to examine whether coroners' recommendations describe a specific role for GPs and RNs in the prevention of premature death in residential aged care settings and, if so, what domains of practice were considered...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29779261/better-diet-quality-is-associated-with-lower-odds-of-severe-periodontitis-in-us-hispanics-latinos
#2
Christian R Salazar, Nadia Laniado, Yasmin Mossavar-Rahmani, Luisa N Borrell, Qibin Qi, Daniela Sotres-Alvarez, Douglas E Morse, Richard H Singer, Robert C Kaplan, Victor Badner, Ira B Lamster
AIM: We investigated the cross-sectional association between diet quality and severe periodontitis in a sample of diverse Hispanics from the Hispanic Community Health Study/Study of Latinos. MATERIALS AND METHODS: A total of 13,920 Hispanic/Latinos aged 18-74 years of different heritages underwent a full-mouth oral examination and completed two 24hr dietary recalls during 2008-2011. Severe periodontitis was defined as having ≥30% tooth sites with clinical attachment loss ≥ 5mm...
May 19, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29779257/linking-seed-germination-and-plant-height-a-case-study-of-a-wetland-community-on-the-eastern-tibet-plateau
#3
Kun Liu, Suzhen Cao, Guozhen Du, Jerry M Baskin, Carol C Baskin, Haiyan Bu, Wei Qi, Ting Liang
Seed germination is the earliest trait expressed in a plant's life history, and it can directly affect the expression of post germination traits. Plant height is central to plant ecological strategies, because it is a major determinant of the ability of a species to compete for light. Thus, linking seed germination and plant height at the community level is very important to understanding plant fitness and community structure. Here, we tested storage condition and temperature requirements for germination of 31 species from a wetland plant community on the eastern Tibet Plateau, and analyzed correlation of germination traits with plant height in relation to storage condition...
May 20, 2018: Plant Biology
https://www.readbyqxmd.com/read/29779245/laparoscopic-technique-of-modified-extraperitoneal-retrotransversalis-end-colostomy-for-abdomino-perineal-resection
#4
I A Tulina, Y E Kitsenko, M N Ubushiev, S K Efetov, S Wexner, P V Tsarkov
AIM: To describe the technique of a modified extraperitoneal retrotransversalis end colostomy as part of a laparoscopic abdomino-perineal resection (APR). METHOD: The colostomy site is preoperatively chosen and intraoperatively used for a trocar. After the rectum has been mobilized the descending colon is freed. The peritoneal margin is gently grasped and the parietal peritoneum, extraperitoneal together with the transversalis fascia are separated from the transverse abdominal muscle fibres upwards for 3-4 cm aiming at the trocar site to form the extraperitoneal retrotransversalis canal...
May 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29779244/diversity-of-epicotyl-dormancy-among-tropical-montane-forest-species-in-sri-lanka
#5
Yasoja S Athugala, K M G G Jayasuriya, A M T A Gunarathne, Carol C Baskin
Fruiting season of many Sri Lankan tropical montane species is not synchronized and may not occur when conditions are favorable for seedling establishment. We hypothesized that species with different fruiting seasons have different seed dormancy mechanisms to synchronize timing of germination with a favorable season for establishment. Using six species with different fruiting seasons, we tested this hypothesis. Germination and imbibition of intact and manually-scarified seeds were studied. Effect of GA3 on germination was examined...
May 20, 2018: Plant Biology
https://www.readbyqxmd.com/read/29779239/indoor-trichoderma-strains-emitting-peptaibols-in-guttation-droplets
#6
E Castagnoli, T Marik, R Mikkola, L Kredics, M A Andersson, H Salonen, J Kurnitski
AIMS: The production of peptaibols, toxic secondary metabolites of Trichoderma, in the indoor environment is not well-documented. Here we investigated the toxicity of peptaibols in the guttation droplets and biomass of Trichoderma strains isolated from problematic buildings. METHODS AND RESULTS: Seven indoor-isolated strains of T. atroviride, T. trixiae, T. paraviridescens and T. citrinoviride were cultivated on malt extract agar, gypsum boards and paperboards. Their biomass extracts and guttation droplets were highly cytotoxic in resting and motile boar sperm cell assays and in inhibition of somatic cell proliferation assays...
May 19, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29779223/gene-editing-vectors-for-studying-nicotinic-acetylcholine-receptors-in-cholinergic-transmission
#7
Can Peng, Yijin Yan, Veronica J Kim, Staci E Engle, Jennifer N Berry, J Michael McIntosh, Rachael L Neve, Ryan M Drenan
Nicotinic acetylcholine receptors (nAChRs), prototype members of the cys-loop ligand gated ion channel family, are key mediators of cholinergic transmission in the central nervous system. Despite their importance, technical gaps exist in our ability to dissect the function of individual subunits in the brain. To overcome these barriers, we designed CRISPR/Cas9 small guide RNA sequences (sgRNAs) for production of loss-of-function alleles in mouse nAChR genes. These sgRNAs were validated in vitro via deep sequencing...
May 19, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29779219/immunohistochemical-and-molecular-analysis-of-spitzoid-neoplasms-with-pulverocyte-subclones
#8
S M Amin, A M Haugh, J A Bubley, A E Verzì, E A Merkel, C Y Lee, V L Quan, E M Garfield, L M Sholl, B Zhang, P Gerami
BACKGROUND: Clonal naevi are characterized by a focal proliferation of pigmented melanocytes in an otherwise banal naevus. These subclones are often composed of aggregates of larger, epithelioid melanocytes with nuclear atypia and dusty-grey cytoplasmic pigmentation, which are referred to as 'pulverocytes', and this finding may lead to a misdiagnosis of malignant melanoma (MM). AIM: To characterize the significance of subclones of dusty-grey pigmented epithelioid melanocytes within spitzoid neoplasms...
May 20, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29779204/hypertensive-disorders-of-pregnancy-and-subsequent-maternal-cardiovascular-health
#9
Nienke E Bergen, Sarah Schalekamp-Timmermans, Jolien Roos-Hesselink, Jeanine E Roeters van Lennep, Vincent V W Jaddoe, Eric A P Steegers
To examine associations between hypertensive pregnancy disorders and maternal cardiovascular disease (CVD) in later life. We examined the associations between blood pressure (BP) in pregnancy, gestational hypertension (GH) and preeclampsia (PE) with cardiovascular measurements 6 years after index pregnancy among 4912 women participating in the Generation R Study, the Netherlands. BP, left ventricular mass (LV mass), aortic root diameter (AOD), left atrial diameter, fractional shortening, and carotid-femoral pulse wave velocity (PWV)...
May 19, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29779196/retrospective-analysis-of-an-insulin-to-liraglutide-switch-in-patients-with-type-2-diabetes-mellitus
#10
Eveline Bruinstroop, Laura Meyer, Catherine B Brouwer, Diana E van Rooijen, P Sytze van Dam
INTRODUCTION: Insulin and the GLP-1 receptor agonist liraglutide are both effective in reaching glycemic targets. The efficacy of an insulin-to-liraglutide switch in an obese population with concurrent use of sulfonylurea and metformin is unknown. We assessed the efficacy and determinants of success of an insulin-to-liraglutide switch in these patients. METHODS: In a retrospective study we analyzed all patients that underwent an insulin-to-liraglutide switch during routine medical care (January 2009-February 2015)...
May 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29779192/impact-of-weak-water-deficit-on-growth-photosynthetic-primary-processes-and-storage-processes-in-pine-and-spruce-seedlings
#11
Ilya E Zlobin, Yury V Ivanov, Alexander V Kartashov, Boris A Sarvin, Andrey N Stavrianidi, Vladimir D Kreslavski, Vladimir V Kuznetsov
We investigated the influence of 40 days of drought on growth, storage processes and primary photosynthetic processes in 3-month-old Scots pine and Norway spruce seedlings growing in perlite culture. Water stress significantly affected seedling water status, whereas absolute dry biomass growth was not substantially influenced. Water stress induced an increase in non-structural carbohydrate content (sugars, sugar alcohols, starch) in the aboveground part of pine seedlings in contrast to spruce seedlings. Due to the relatively low content of sugars and sugar alcohols in seedling organs, their expected contribution to osmotic potential changes was quite low...
May 19, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29779184/limbic-system-structure-volumes-and-associated-neurocognitive-functioning-in-former-nfl-players
#12
Christian Lepage, Marc Muehlmann, Yorghos Tripodis, Jakob Hufschmidt, Julie Stamm, Katie Green, Pawel Wrobel, Vivian Schultz, Isabelle Weir, Michael L Alosco, Christine M Baugh, Nathan G Fritts, Brett M Martin, Christine Chaisson, Michael J Coleman, Alexander P Lin, Ofer Pasternak, Nikos Makris, Robert A Stern, Martha E Shenton, Inga K Koerte
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts. CTE has been linked to disruptions in cognition, mood, and behavior. Unfortunately, the diagnosis of CTE can only be made post-mortem. Neuropathological evidence suggests limbic structures may provide an opportunity to characterize CTE in the living. Using 3 T magnetic resonance imaging, we compared select limbic brain regional volumes - the amygdala, hippocampus, and cingulate gyrus - between symptomatic former National Football League (NFL) players (n = 86) and controls (n = 22)...
May 19, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29779178/organophosphate-pesticides-alter-blue-crab-callinectes-sapidus-behavior-in-single-and-consecutive-exposures
#13
Kelly M Correia, Delbert L Smee
Insecticide effects on nontarget organisms most commonly involve measuring mortality after single exposures. We examined sublethal effects of consecutive exposures of malathion, an organophosphate insecticide used for mosquito abatement, on the behavior of blue crabs (Callinectes sapidus). We measured righting time (i.e., time to return upright when placed upside down), eyestalk reflexes, foraging ability, and response to predation risk in three malathion treatments of 50 µg/L that varied in duration: (1) static exposure for 96 h followed by a second exposure for 96 h, (2) static exposure for 96 h followed by transfer to pesticide-free water for 96 h, (3) control without malathion for 192 h...
May 19, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29779176/intranasal-delivery-of-pgdnf-dna-nanoparticles-provides-neuroprotection-in-the-rat-6-hydroxydopamine-model-of-parkinson-s-disease
#14
Amirah E-E Aly, Brendan T Harmon, Linas Padegimas, Ozge Sesenoglu-Laird, Mark J Cooper, Barbara L Waszczak
Glial cell line-derived neurotrophic factor (GDNF) gene therapy could offer a disease-modifying treatment for Parkinson's disease (PD). Here, we report that plasmid DNA nanoparticles (NPs) encoding human GDNF administered intranasally to rats induce transgene expression in the brain and protect dopamine neurons in a model of PD. To first test whether intranasal administration could transfect cells in the brain, rats were sacrificed 1 week after intranasal pGDNF NPs or the naked plasmid. GDNF ELISA revealed significant increases in GDNF expression throughout the brain for both treatments...
May 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29779137/ulnar-neuropathy-at-wrist-entrapment-at-a-very-congested-site
#15
Daniele Coraci, Claudia Loreti, Giulia Piccinini, Pietro E Doneddu, Silvia Biscotti, Luca Padua
Ulnar tunnel syndrome indicates ulnar neuropathy at different sites within the wrist. Several classifications of ulnar tunnel syndrome are present in literature, based upon typical nerve anatomy. However, anatomical variations are not uncommon and can complicate assessment. The etiology is also complex, due to the numerous potential causes of entrapment. Clinical examination, neurophysiological testing, and imaging are all used to support the diagnosis. At present, many therapeutic approaches are available, ranging from observation to surgical management...
May 19, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29779120/discounting-in-economic-evaluations
#16
REVIEW
Arthur E Attema, Werner B F Brouwer, Karl Claxton
Appropriate discounting rules in economic evaluations have received considerable attention in the literature and in national guidelines for economic evaluations. Rightfully so, as discounting can be quite influential on the outcomes of economic evaluations. The most prominent controversies regarding discounting involve the basis for and height of the discount rate, whether costs and effects should be discounted at the same rate, and whether discount rates should decline or stay constant over time. Moreover, the choice for discount rules depends on the decision context one adopts as the most relevant...
May 19, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29779114/general-sources-of-dopamine-as-a-potential-morphogenic-factor-in-the-developing-striatum-of-rats
#17
A I Kurtova, L K Dil'mukhametova, E R Mingazov, M V Ugrumov
In the striatum of rats at different stages of development, we determined the content of tyrosine hydroxylase and aromatic L-amino acids decarboxylase using double immunohistochemical labeling and estimated the expression level of their transcripts by real-time PCR. We found that, in different periods of development, there are three sources of dopamine in the striatum of rats: bienzymatic nerve fibers (throughout ontogeny), bienzymatic neurons (appear on day 18 of embryonic development), and monoenzymatic neurons (in adult animals)...
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29779111/magnetosensitivity-of-e-coli-bacteria-in-the-presence-of-zinc-isotopes
#18
U G Letuta, D M Shailina
The combined effect of the zinc magnetic isotope 67 Zn and weak magnetic field 25-35 mT causes a 2-4-fold increase in the colony-forming ability of bacteria E. coli in comparison with the nonmagnetic isotopes 64, 66 Zn. The effects of magnetic field in the range of 2.2-8 mT were detected for all bacteria regardless of the zinc-isotope enrichment of the media. This indicates the sensitivity of intracellular processes to weak magnetic fields. An increase in the ATP concentration in E. coli cells was only detected for the bacteria grown on the medium with the magnetic zinc isotope in the range of 2...
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29779109/the-gene-encoding-the-universal-stress-protein-atusp-is-regulated-by-phytohormones-and-involved-in-seed-germination-of-arabidopsis-thaliana
#19
D S Gorshkova, I A Getman, A S Voronkov, S I Chizhova, Vl V Kuznetsov, E S Pojidaeva
For the first time, the organ-specific expression pattern of the AtUSP (At3g58450) gene, which also undergoes hormonal regulation, was shown. The USP protein encoded by this gene is involved in seed germination of Arabidopsis thaliana and, unlike abscisic acid, stimulates this process.
March 2018: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29779108/microrna-dependent-regulation-of-igf1r-gene-expression-in-hormone-sensitive-and-hormone-resistant-prostate-cancer-cells
#20
V A Tarasov, M G Tyutyakina, M A Makhotkin, E F Shin, A V Naboka, A N Mashkarina, D A Chebotarev, E N Cherkasova, M I Kogan, M B Chibichyan, D G Matishov
Using multiple parallel sequencing on Illumina platform, we identified eight microRNAs that showed significant opposite changes of gene expression in cells of the hormone-sensitive LNCaP prostate cancer cell line and in cells of the hormone-resistant DU-145 cell line, in comparison to the microRNA expression in the normal prostate tissue cells. We found that the insulin-like growth factor 1 receptor (IGF1R) gene is a target of five microRNAs whose expression is increased in LNCaP cells and reduced in DU-145 cells...
March 2018: Doklady. Biochemistry and Biophysics
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