keyword
https://read.qxmd.com/read/36986696/cannabimimetic-n-stearoylethanolamine-as-double-edged-sword-in-anticancer-chemotherapy-proapoptotic-effect-on-tumor-cells-and-suppression-of-tumor-growth-versus-its-bio-protective-actions-in-complex-with-polymeric-carrier-on-general-toxicity-of-doxorubicin
#21
JOURNAL ARTICLE
Rostyslav Panchuk, Nadiya Skorokhyd, Vira Chumak, Lilya Lehka, Halyna Kosiakova, Tetyana Horid'ko, Iehor Hudz, Nadiya Hula, Anna Riabtseva, Nataliya Mitina, Alexander Zaichenko, Petra Heffeter, Walter Berger, Rostyslav Stoika
This study reports a dose-dependent pro-apoptotic action of synthetic cannabimimetic N -stearoylethanolamine (NSE) on diverse cancer cell lines, including multidrug-resistant models. No antioxidant or cytoprotective effects of NSE were found when it was applied together with doxorubicin. A complex of NSE with the polymeric carrier poly(5-(tert-butylperoxy)-5-methyl-1-hexen-3-yn-co-glycidyl methacrylate)-graft-PEG was synthesized. Co-immobilization of NSE and doxorubicin on this carrier led to a 2-10-fold enhancement of the anticancer activity, particularly, against drug-resistant cells overexpressing ABCC1 and ABCB1...
March 3, 2023: Pharmaceutics
https://read.qxmd.com/read/36958194/novel-gold-i-complexes-induce-apoptosis-in-leukemia-cells-via-the-ros-induced-mitochondrial-pathway-with-an-upregulation-of-harakiri-and-overcome-multi-drug-resistances-in-leukemia-and-lymphoma-cells-and-sensitize-drug-resistant-tumor-cells-to-apoptosis-in
#22
JOURNAL ARTICLE
Marie-C Ahrweiler-Sawaryn, Animesh Biswas, Corazon Frias, Jerico Frias, Nicola L Wilke, Nathalie Wilke, Albrecht Berkessel, Aram Prokop
Gold complexes could be promising for tumor therapy because of their cytotoxic and cytostatic properties. We present novel gold(I) complexes and clarify whether they also show antitumor activity by studying apoptosis induction in different tumor cell lines in vitro, comparing the compounds on resistant cells and analyzing the mechanism of action. We particularly highlight one gold complex that shows cytostatic and cytotoxic effects on leukemia and lymphoma cells already in the nanomolar range, induces apoptosis via the intrinsic signaling pathway, and plays a role in the production of reactive oxygen species...
March 21, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/36909730/the-gastrointestinal-antibiotic-resistome-in-pediatric-leukemia-and-lymphoma-patients
#23
JOURNAL ARTICLE
Tamara MacDonald, Katherine A Dunn, Jane MacDonald, Morgan G I Langille, Johan E Van Limbergen, Joseph P Bielawski, Ketan Kulkarni
INTRODUCTION: Most children with leukemia and lymphoma experience febrile neutropenia. These are treated with empiric antibiotics that include β-lactams and/or vancomycin. These are often administered for extended periods, and the effect on the resistome is unknown. METHODS: We examined the impact of repeated courses and duration of antibiotic use on the resistome of 39 pediatric leukemia and lymphoma patients. Shotgun metagenome sequences from 127 stool samples of pediatric oncology patients were examined for abundance of antibiotic resistance genes (ARGs) in each sample...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/36765483/-effect-of-mir-424-5p-on-the-drug-resistance-of-diffuse-large-b-cell-lymphoma-cells-by-regulating-pd-1-pd-l1-signaling-pathway
#24
JOURNAL ARTICLE
Jun Yuan, Hu Han, Wei Dong, Rui-Cang Wang, Hong-Ling Hao
OBJECTIVE: To explore the effect of microRNA-424-5p (miR-424-5p) on the drug resistance of diffuse large B-cell lymphoma (DLBCL) cells by regulating the programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) signaling pathway. METHODS: Human DLBCL cell line CRL2631 cells were induced to construct CRL2631-CHOP resistant cell line. RT-qPCR and Western blot were used to detect the expression levels of MiR-424-5p , PD-L1 mRNA and protein, and multidrug resistance gene-1 (MDR-1) protein in CRL2631 cells and CRL2631-CHOP cells, respectively...
February 2023: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/36757936/upregulation-of-programmed-death-ligand-1-in-tumor-associated-macrophages-affects-chemotherapeutic-response-in-ovarian-cancer-cells
#25
JOURNAL ARTICLE
Yong Soo Jang, Tae Wan Kim, Jae Sung Ryu, Hye Jeong Kong, Si Hyeong Jang, Gye Hyun Nam, Jae Hoon Kim, Seob Jeon
To better understand the mechanism of chemoresistance in ovarian cancer cells, we aimed to investigate the influence of macrophages on the tumor cell response to carboplatin and identify the genes associated with chemoresistance. We mimicked the tumor microenvironment (TME) using a co-culture technique and compared the proliferation of ovarian cells with and without macrophages. We also examined M1 and M2 marker expression and the expression of key TME genes. Post the co-culture, we treated ovarian cancer cells with carboplatin and elucidated the function of programmed death-ligand 1 (PD-L1) in carboplatin chemoresistance...
2023: PloS One
https://read.qxmd.com/read/36683273/4-methylthiobutyl-isothiocyanate-synergize-the-antiproliferative-and-pro-apoptotic-effects-of-paclitaxel-in-human-breast-cancer-cells
#26
JOURNAL ARTICLE
Harneetpal Kaur, Atamjit Singh, Kirandeep Kaur, Ajay Kumar, Shivani Attri, Farhana Rashid, Sharabjit Singh, Neena Bedi, Hardeep Singh Tuli, Shafiul Haque, Khalil Alkuwaity, Hanaa M Tashkandi, Steve Harakeh, Saroj Arora
Multidrug resistance (MDR) is considered as a major obstacle in achieving an effective treatment of breast cancer. Paclitaxel has been used to treat cancers of the cervical, breast, ovarian and brain but MDR limits its therapeutic potential. Phytochemicals have received much interest in recent decades especially in combination approaches to tackle MDR due to their negligible harm to healthy cells and synergistic potential. Considering this notion, the present study aimed at investigating the synergistic activity of 4-MTBITC and PTX against a panel of breast cancer cells...
January 22, 2023: Biotechnology & Genetic Engineering Reviews
https://read.qxmd.com/read/36674465/ruthenium-complex-hb324-induces-apoptosis-via-mitochondrial-pathway-with-an-upregulation-of-harakiri-and-overcomes-cisplatin-resistance-in-neuroblastoma-cells-in-vitro
#27
JOURNAL ARTICLE
Nicola L Wilke, Hilke Burmeister, Corazon Frias, Ingo Ott, Aram Prokop
Ruthenium(II) complexes with N-heterocyclic carbene (NHC) ligands have recently attracted attention as novel chemotherapeutic agents. The complex HB324 was intensively studied as an apoptosis-inducing compound in resistant cell lines. HB324 induced apoptosis via mitochondrial pathways. Of particular interest is the upregulation of the Harakiri resistance protein, which inhibits the anti-apoptotic and death repressor proteins Bcl-2 (B-cell lymphoma 2) and BCL-xL (B-cell lymphoma-extra large). Moreover, HB324 showed synergistic activity with various established anticancer drugs and overcame resistance in several cell lines, such as neuroblastoma cells...
January 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36512933/clarithromycin-and-metronidazole-resistant-helicobacter-pylori-isolated-from-raw-and-ready-to-eat-meat-in-mansoura-egypt
#28
JOURNAL ARTICLE
Aya Elsayed Maghrabia, Hend Ali Elshebrawy, Mahmoud Ahmed Mahros, Mohammed Mohammed Elgazzar, Khalid Ibrahim Sallam
Helicobacter pylori (H. pylori), classified as a class-I carcinogen, is one of the leading medical pathogens of global concern associated mainly with the development of gastric adenocarcinomas and gastric mucosa-associated lymphoid tissue lymphomas; nevertheless, its prevalence in food especially meat and meat products is not fully covered. Additionally, the resistance of H. pylori towards clarithromycin is increasing worldwide and consider the leading cause of H. pylori treatment failure. Thus, the present study was designed to determine the prevalence, molecular characterization, and antimicrobial resistance profiles of clarithromycin-, and metronidazole-resistant H...
December 8, 2022: International Journal of Food Microbiology
https://read.qxmd.com/read/36411649/the-gallium-complex-kp46-sensitizes-resistant-leukemia-cells-and-overcomes-bcl-2-induced-multidrug-resistance-in-lymphoma-cells-via-upregulation-of-harakiri-and-downregulation-of-xiap-in-vitro
#29
JOURNAL ARTICLE
Nicola L Wilke, Liliane Onambele Abodo, Corazon Frias, Jerico Frias, Jennifer Baas, Michael A Jakupec, Bernhard K Keppler, Aram Prokop
Tris-(8-quinolinolato)gallium(III) (KP46, AP-002) is an orally administered investigational anticancer and bone-protective drug currently being evaluated in patients with advanced solid tumors with bone involvement. Despite the clinical efficacy of other gallium compounds in non-Hodgkin's lymphoma, effects of KP46 in hematological tumor settings have not been studied systematically before. We report here intriguing activities in various human cell lines, including such with multidrug resistance (MDR): In Nalm-6 lymphoblastic leukemia cell sublines, KP46 was capable of overcoming P-gp-related as well as P-gp-unrelated MDR...
December 2022: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/36371600/successful-treatment-of-ceftazidime-avibactam-combined-with-aztreonam-in-the-ndm-producing-klebsiella-pneumoniae-bloodstream-and-intestinal-infections-in-a-nk-t-lymphoma-patient-with-agranulocytosis-during-autologous-hematopoietic-stem-cell-transplantation
#30
JOURNAL ARTICLE
Shiyi Liu, Qingqing Lin, Lizhi Ouyang, Chengjie Zhou, Huajun Wang
New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae is increasingly reported worldwide. Clinicians face significant challenges in the treatment of this multidrug-resistant bacterium. The combination of ceftazidime/avibactam (CAZ/AVI) and aztreonam (ATM) is currently probably the most effective strategy for the treatment of such infection. We described a patient diagnosed with NK/T cell lymphoma who underwent autologous hematopoietic stem cell transplantation (ASCT) in the hematology department...
November 12, 2022: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/36320328/an-organometallic-analogue-of-combretastatin-a-4-and-its-apoptosis-inducing-effects-on-lymphoma-leukemia-and-other-tumor-cells-in-vitro
#31
JOURNAL ARTICLE
Liliane Abodo Onambele, Natalie Hoffmann, Lisa Kater, Lars Hemmersbach, Jörg-Martin Neudörfl, Nikolay Sitnikov, Benjamin Kater, Corazon Frias, Hans-Günther Schmalz, Aram Prokop
Hexacarbonyl[1,3-dimethoxy-5-((4'-methoxyphenyl)ethynyl)benzene]dicobalt (NAHO27), an organometallic analogue of combretastatin A-4, has been synthesized and its activity against lymphoma, leukemia, breast cancer and melanoma cells has been investigated. It was shown that NAHO27 specifically induces apoptosis in BJAB lymphoma and Nalm-6 leukemia cells at low micromolar concentration and does not affect normal leukocytes in vitro . It also proved to be active against vincristine and daunorubicin resistant leukemia cell lines with p-glycoprotein-caused multidrug resistance and showed a pronounced (550%) synergistic effect when co-applied with vincristine at very low concentrations...
September 21, 2022: RSC medicinal chemistry
https://read.qxmd.com/read/36318018/pixantrone-sensitizes-gram-negative-pathogens-to-rifampin
#32
JOURNAL ARTICLE
Pengfei She, Zehao Li, Yimin Li, Shasha Liu, Linhui Li, Yifan Yang, Linying Zhou, Yong Wu
The emergence of bacterial drug resistance poses a severe threat to global public health. In particular, antimicrobial-resistant pathogens lead to a high rate of treatment failure and significantly increase mortality. Repurposing FDA-approved compounds to sensitize superbugs to conventional antibiotics provides a promising strategy to alleviate such crises. Pixantrone (PIX) has been approved for treating aggressive B-cell non-Hodgkin's lymphoma. By high-throughput drug screening, we profiled the synergistic activity between PIX and rifampin (RFP) against Gram-negative extensively drug-resistant isolates by checkerboard assay...
November 1, 2022: Microbiology Spectrum
https://read.qxmd.com/read/36179403/seleno-vs-thioether-triazine-derivatives-in-search-for-new-anticancer-agents-overcoming-multidrug-resistance-in-lymphoma
#33
JOURNAL ARTICLE
Wesam Ali, Sabrina Garbo, Annamária Kincses, Márta Nové, Gabriella Spengler, Elisabetta Di Bello, Ewelina Honkisz-Orzechowska, Tadeusz Karcz, Ewa Szymańska, Ewa Żesławska, Małgorzata Starek, Monika Dąbrowska, Wojciech Nitek, Katarzyna Kucwaj-Brysz, Patryk Pyka, Rossella Fioravanti, Claus Jacob, Cecilia Battistelli, Clemens Zwergel, Jadwiga Handzlik
Lymphomas are still difficult to treat even with modern therapies as, among others, multidrug resistance (MDR) is often counteracting a successful cancer therapy. P-gp/ABC-transporters are well-known for their crucial role in the main tumour MDR mechanism, eliminating drugs and cytotoxic substances from the cancer cell by efflux, and their modulators are promising for innovative therapy, but none has been approved in the pharmaceutical market yet. Herein, we have designed, synthesised and analysed 30 novel seleno- and thioether 1,3,5-triazine derivatives conducting comprehensive studies to evaluate their potential application in human JURKAT lymphoma cells...
September 19, 2022: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/36164143/mm-134-comparable-toxicity-and-outcomes-with-generic-and-innovator-melphalan-in-myeloma-auto-transplants
#34
JOURNAL ARTICLE
Anup Joseph Devasia, Aswin Anand Pai, Mithun Abraham Prakash, Kavita M Lakshmi, Anu Korula, Uday Kulkarni, Fouzia N Aboobacker, Sharon Lionel, Sushil Selvarajan, Aby Abraham, Alok Srivastava, Vikram Mathews, Poonkuzhali Balasubramanian, Biju George
INTRODUCTION: Autologous stem cell transplantation (ASCT) with high-dose melphalan (HDM) is the standard consolidation treatment for transplant-eligible multiple myeloma (MM) patients. Many countries use generic melphalan (MEL) due to its low cost and easy availability. We previously reported the comparable pharmacokinetics and efficacy of generic and innovator MEL in a cohort of 65 patients from our center. Here, we present the updated data and long-term follow-up in an extended cohort of 120 patients...
October 2022: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/36164125/tcl-276-outcome-of-nk-t-cell-lymphoma-retrospective-analysis-from-a-tertiary-care-cancer-center
#35
JOURNAL ARTICLE
Akhil Rajendra, Manju Sengar, Avinash Bonda, Hasmukh Jain, Lingaraj Nayak, Sridhar Epari, Tanuja Shet, Jayashree Thorat, Bhausaheb Bagal, Archi Agarwal, Venkatesh Rangarajan, Vasu Babu, Sumeet Gujral
CONTEXT: Extra-nodal natural killer (NK)/T-cell lymphoma is a rare, distinctive clinicopathologic entity with an aggressive clinical course. High expression of multidrug-resistant (MDR) P-gp on NK lymphoma cells renders this disease resistant to anthracycline-based chemotherapy regimens. Over the years, based on retrospective analysis and phase II studies, regimens with L-asparaginase and non-MDR drugs have been used. OBJECTIVE: To evaluate the outcome of patients with extra-nodal NK/T-cell lymphoma treated in a tertiary cancer care center in India from 2012 to 2021...
October 2022: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/36163815/aml-332-antibiotic-resistance-profile-of-blood-culture-isolates-in-neutropenics-in-morocco
#36
JOURNAL ARTICLE
Kawtar Tlohi, Mouna Lemchaheb, Sophia Berrada, Hajar Maataoui Belabess, Khalid Zerouali, Mohamed Rachid, Meryem Qachouh, Amine Benmoussa, Siham Cherkaoui, Nissrine Khoubila, Abdellah Madani
CONTEXT: The emergence of bacterial resistance to antibiotics is an international health issue affecting all age groups and all clinical profiles. These multidrug-resistances lead to therapeutic impasses and pose a problem of therapeutic management, particularly in immunocompromised patients. OBJECTIVE: The aim of our study is to highlight the different germs isolated in blood culture as well as their antibiotic resistance profiles in patients hospitalized on the protected side of our department...
October 2022: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/36163729/all-204-barriers-to-improving-outcomes-of-children-with-acute-lymphoblastic-leukemia-in-low-to-middle-income-countries
#37
JOURNAL ARTICLE
Hanafy Hafez, Shimaa Nazih, Dalia Negm Eldin, Ahmed Elgammal
CONTEXT: Despite recent improvements in supportive care services, treatment deaths remain one of the major problems that affect the outcome of pediatric acute lymphoblastic leukemia (ALL), especially in middle-income countries. OBJECTIVES: The study aimed to assess the incidence, risk factors, and outcomes of treatment-related complications during therapy of pediatric ALL. PATIENTS AND METHODS: A retrospective study included patients ≤18 years old with pediatric ALL, treated according to St...
October 2022: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/36147518/nanoparticles-design-considerations-to-co-deliver-nucleic-acids-and-anti-cancer-drugs-for-chemoresistance-reversal
#38
JOURNAL ARTICLE
Sahar Eljack, Stephanie David, Areeg Faggad, Igor Chourpa, Emilie Allard-Vannier
Chemoresistance and hence the consequent treatment failure is considerably challenging in clinical cancer therapeutics. The understanding of the genetic variations in chemoresistance acquisition encouraged the use of gene modulatory approaches to restore anti-cancer drug efficacy. Many smart nanoparticles are designed and optimized to mediate combinational therapy between nucleic acid and anti-cancer drugs. This review aims to define a rational design of such co-loaded nanocarriers with the aim of chemoresistance reversal at various cellular levels to improve the therapeutic outcome of anticancer treatment...
December 2022: International journal of pharmaceutics: X
https://read.qxmd.com/read/36142724/5-arylidenerhodanines-as-p-gp-modulators-an-interesting-effect-of-the-carboxyl-group-on-abcb1-function-in-multidrug-resistant-cancer-cells
#39
JOURNAL ARTICLE
Ewa Żesławska, Waldemar Tejchman, Annamária Kincses, Gabriella Spengler, Wojciech Nitek, Grzegorz Żuchowski, Ewa Szymańska
Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractive research directions is focused on the inhibition of MDR transporters, membrane proteins that extrude cytotoxic drugs from living cells. Here, we report the results of our studies on a series newly synthesized of 5-arylidenerhodanines and their ability to inhibit the ABCB1 efflux pump in mouse T-lymphoma cancer cells...
September 16, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36109322/impact-of-fluoroquinolone-prophylaxis-on-neutropenic-fever-infections-and-antimicrobial-resistance-in-newly-diagnosed-aml-patients
#40
JOURNAL ARTICLE
Jessica Caro, Rafael Madero-Marroquin, Nicole Zubizarreta, Erin Moshier, Douglas Tremblay, Alex Coltoff, Guido Lancman, Risa Fuller, Meenakshi Rana, John Mascarenhas, Samantha E Jacobs
INTRODUCTION: Fluoroquinolone prophylaxis is recommended during induction chemotherapy for patients with acute myeloid leukemia (AML) to reduce risk of neutropenic fever and systemic bacterial infections. We evaluated the effectiveness of primary fluoroquinolone prophylaxis in an area with high fluoroquinolone resistance. MATERIALS AND METHODS: We performed a retrospective chart review of newly diagnosed adult AML patients who received frontline therapy at Mount Sinai Hospital in New York, NY, between 2012 and 2019...
August 7, 2022: Clinical Lymphoma, Myeloma & Leukemia
keyword
keyword
30497
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.