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https://www.readbyqxmd.com/read/29470452/who-environmental-noise-guidelines-for-the-european-region-a-systematic-review-on-environmental-noise-and-cardiovascular-and-metabolic-effects-a-summary
#1
REVIEW
Elise van Kempen, Maribel Casas, Göran Pershagen, Maria Foraster
To update the current state of evidence and assess its quality, we conducted a systematic review on the effects of environmental noise exposure on the cardio-metabolic systems as input for the new WHO environmental noise guidelines for the European Region. We identified 600 references relating to studies on effects of noise from road, rail and air traffic, and wind turbines on the cardio-metabolic system, published between January 2000 and August 2015. Only 61 studies, investigating different end points, included information enabling estimation of exposure response relationships...
February 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29465596/tianma-gouteng-decoction-for-essential-hypertension-protocol-for-a-systematic-review-and-meta-analysis
#2
Benjian Chen, Yuanping Wang, Zhuogen He, Dawei Wang, Xia Yan, Pingchang Xie
BACKGROUND: Essential hypertension is one of the most common chronic diseases, as well as one of the leading risk factors for cardio-cerebrovascular diseases. Tianma Gouteng decoction has been commonly used in clinical practice for patients with essential hypertension. It is important to update the search and evaluation to provide the best available evidence for essential hypertension. Here, we provide a protocol to evaluate the efficacy and safety of Tianma Gouteng decoction (TGD) for essential hypertension...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29464808/cancer-diagnosis-in-patients-with-heart-failure-epidemiology-clinical-implications-and-gaps-in-knowledge
#3
REVIEW
Pietro Ameri, Marco Canepa, Markus S Anker, Yury Belenkov, Jutta Bergler-Klein, Alain Cohen-Solal, Dimitrios Farmakis, Teresa López-Fernández, Mitja Lainscak, Radek Pudil, Frank Ruschitska, Petar Seferovic, Gerasimos Filippatos, Andrew Coats, Thomas Suter, Stephan Von Haehling, Fortunato Ciardiello, Rudolf A de Boer, Alexander R Lyon, Carlo G Tocchetti
Cancer and heart failure (HF) are common medical conditions with a steadily rising prevalence in industrialized countries, particularly in the elderly, and they both potentially carry a poor prognosis. A new diagnosis of malignancy in subjects with pre-existing HF is not infrequent, and challenges HF specialists as well as oncologists with complex questions relating to both HF and cancer management. An increased incidence of cancer in patients with established HF has also been suggested. This review paper summarizes the epidemiology and the prognostic implications of cancer occurrence in HF, the impact of pre-existing HF on cancer treatment decisions and the impact of cancer on HF therapeutic options, while providing some practical suggestions regarding patient care and highlighting gaps in knowledge...
February 21, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29458747/sex-specific-associations-between-extreme-sleep-duration-and-prevalence-of-cardio-cerebral-vascular-disease-a-community-based-cross-sectional-study
#4
Juzhong Ke, Xianfeng Zhou, Hua Qiu, Siyu Yu, Kang Wu, Xinyi Rui, Xiaonan Wang, Xiaolin Liu, Tao Lin, Xiaonan Ruan
BACKGROUND: Most previous studies on sleep duration and cardio-cerebral vascular disease (CCVD) association have not adequately controlled for many confounders. The current study prospectively examined the association of sleep duration with CCVD prevalence in a Chinese community population; cardiovascular risk factors, chronic diseases, and sleep quality were taken into consideration. METHODS: A cross-sectional study conducted in Pudong New Area of Shanghai, China...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29458412/comparison-of-volatile-anesthetic-induced-preconditioning-in-cardiac-and-cerebral-system-molecular-mechanisms-and-clinical-aspects
#5
REVIEW
Shasha Chen, Christopher Lotz, Norbert Roewer, Jens-Albert Broscheit
Volatile anesthetic-induced preconditioning (APC) has shown to have cardiac and cerebral protective properties in both pre-clinical models and clinical trials. Interestingly, accumulating evidences demonstrate that, except from some specific characters, the underlying molecular mechanisms of APC-induced protective effects in myocytes and neurons are very similar; they share several major intracellular signaling pathways, including mediating mitochondrial function, release of inflammatory cytokines and cell apoptosis...
February 20, 2018: European Journal of Medical Research
https://www.readbyqxmd.com/read/29457984/cardio-oncology-the-role-of-advanced-echocardiography-in-cancer-patients
#6
Lucia Venneri, Giacomo Zoppellaro, Rajdeep S Khattar
Cardio-oncology is a rapidly growing field aimed at improving the quality of care of cancer patients by preventing and monitoring cardiovascular complications resulting from cancer treatment. Cardiac imaging, and in particular, transthoracic echocardiography, plays an essential role in the baseline assessment and serial follow-up of cardio-oncology patients. Areas covered: This review article discusses the role of cardiac imaging with a focus on advanced echocardiography for the detection and management of cancer therapy related cardiovascular complications, in particular, left ventricular dysfunction and heart failure...
February 19, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29454137/mechanisms-and-management-of-refractory-ventricular-arrhythmias-in-the-age-of-autonomic-modulation
#7
Jason S Bradfield, Olujimi A Ajijola, Marmar Vaseghi, Kalyanam Shivkumar
Ventricular arrhythmias are responsible for hundreds of thousands of deaths every year. Catheter ablation of ventricular tachycardia (VT) is an essential component of the management of these life-threatening arrhythmias. However, in many patients, despite medical and interventional therapy, VT recurs. Further, some VT substrates (mid-myocardial, left ventricular summit, intra-septal) are not easily targeted, due to limitations of currently available technology. In certain clinical settings, ventricular fibrillation (VF) episodes that have premature ventricular contraction (PVC) triggers can also be targeted with catheter ablation...
February 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29439389/early-life-exposure-to-non-nutritive-sweeteners-and-the-developmental-origins-of-childhood-obesity-global-evidence-from-human-and-rodent-studies
#8
REVIEW
Alyssa J Archibald, Vernon W Dolinsky, Meghan B Azad
Non-nutritive sweeteners (NNS) are increasingly consumed by children and pregnant women around the world, yet their long-term health impact is unclear. Here, we review an emerging body of evidence suggesting that early-life exposure to NNS may adversely affect body composition and cardio-metabolic health. Some observational studies suggest that children consuming NNS are at increased risk for obesity-related outcomes; however, others find no association or provide evidence of confounding. Fewer studies have examined prenatal NNS exposure, with mixed results from different analytical approaches...
February 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29429026/modulation-of-renal-sympathetic-innervation-recent-insights-beyond-blood-pressure-control
#9
REVIEW
Dominik Linz, Mathias Hohl, Adrian D Elliott, Dennis H Lau, Felix Mahfoud, Murray D Esler, Prashanthan Sanders, Michael Böhm
Renal afferent and efferent sympathetic nerves are involved in the regulation of blood pressure and have a pathophysiological role in hypertension. Additionally, several conditions that frequently coexist with hypertension, such as heart failure, obstructive sleep apnea, atrial fibrillation, renal dysfunction, and metabolic syndrome, demonstrate enhanced sympathetic activity. Renal denervation (RDN) is an approach to reduce renal and whole body sympathetic activation. Experimental models indicate that RDN has the potential to lower blood pressure and prevent cardio-renal remodeling in chronic diseases associated with enhanced sympathetic activation...
February 10, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29427757/evaluation-of-the-extent-of-adaptation-to-sample-size-in-clinical-trials-for-cardiovascular-and-cns-diseases
#10
Sue-Jane Wang, Hua Peng, Hsien-Ming James Hung
A planned adaptation to sample size in an ongoing trial aims at providing an opportunity to modify design assumptions made at the trial planning stage. Reassessment of sample size in an ongoing trial may be performed in a non-comparative or a comparative fashion, either with or without use of external data that surface. We review the completed new drug applications (NDAs) and biologic license applications (BLAs) submitted since 2000 to cardio-renal, neurology and psychiatry drug products divisions of Center for Drug Evaluation and Research, U...
February 7, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29426298/albuminuria-serum-creatinine-and-estimated-glomerular-filtration-rate-as-predictors-of-cardio-renal-outcomes-in-patients-with-type-2-diabetes-mellitus-and-kidney-disease-a-systematic-literature-review
#11
Keith C Norris, Karen E Smoyer, Catherine Rolland, Jan Van der Vaart, Eliza Beth Grubb
BACKGROUND: Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are pivotal indicators of kidney decline. Yet, it is uncertain if these and emerging biomarkers such as uric acid represent independent predictors of kidney disease progression or subsequent outcomes among individuals with type 2 diabetes mellitus (T2DM). This study systematically examined the available literature documenting the role of albuminuria, serum creatinine, eGFR, and uric acid in predicting kidney disease progression and cardio-renal outcomes in persons with T2DM...
February 9, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29421859/review-shows-that-maternal-obesity-induces-serious-adverse-neonatal-effects-and-is-associated-with-childhood-obesity-in-their-offspring
#12
REVIEW
Delphine Mitanchez, Pascale Chavatte-Palmer
AIM: Obesity at the start of pregnancy has been rising worldwide, increasing the risk of maternal complications. We reviewed the independent effects of maternal obesity during pregnancy on neonatal adverse outcomes and the risk of childhood obesity and adverse cardio-metabolic profiles. METHODS: We searched MEDLINE for papers published in English between December 2007 and November 2017, focusing primarily on human studies published in the last five years. However, we also chose to highlight examples derived from model animals that could bring mechanistic insight and preventive and therapeutic avenues...
February 8, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29419624/intermittent-fasting-interventions-for-treatment-of-overweight-and-obesity-in-adults-a-systematic-review-and-meta-analysis
#13
Leanne Harris, Sharon Hamilton, Liane B Azevedo, Joan Olajide, Caroline De Brún, Gillian Waller, Vicki Whittaker, Tracey Sharp, Mike Lean, Catherine Hankey, Louisa Ells
OBJECTIVE: To examine the effectiveness of intermittent energy restriction in the treatment for overweight and obesity in adults, when compared to usual care treatment or no treatment. INTRODUCTION: Intermittent energy restriction encompasses dietary approaches including intermittent fasting, alternate day fasting, and fasting for two days per week. Despite the recent popularity of intermittent energy restriction and associated weight loss claims, the supporting evidence base is limited...
February 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29415476/the-impact-of-aging-on-cardio-and-cerebrovascular-diseases
#14
REVIEW
Carmine Izzo, Albino Carrizzo, Antonia Alfano, Nicola Virtuoso, Mario Capunzo, Mariaconsiglia Calabrese, Eros De Simone, Sebastiano Sciarretta, Giacomo Frati, Marco Oliveti, Antonio Damato, Mariateresa Ambrosio, Francesco De Caro, Paolo Remondelli, Carmine Vecchione
A growing number of evidences report that aging represents the major risk factor for the development of cardio and cerebrovascular diseases. Understanding Aging from a genetic, biochemical and physiological point of view could be helpful to design a better medical approach and to elaborate the best therapeutic strategy to adopt, without neglecting all the risk factors associated with advanced age. Of course, the better way should always be understanding risk-to-benefit ratio, maintenance of independence and reduction of symptoms...
February 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29410351/fibroblast-growth-factor-21-in-cardio-metabolic-disorders-a-systematic-review-and-meta-analysis
#15
Ishan Lakhani, Mengqi Gong, Wing Tak Wong, George Bazoukis, Konstantinos Lampropoulos, Sunny Hei Wong, William K K Wu, Martin C S Wong, Kwok-Leung Ong, Tong Liu, Gary Tse
BACKGROUND: Fibroblast growth factor 21 is a signalling protein involved in cell differentiation, morphogenesis, proliferation and metabolism. Recent studies have associated increased levels of FGF21 in the development of cardiovascular diseases, whereas others have reported no significant associations. Therefore, this systematic review and meta-analysis evaluated the its value in predicting the risk of cardio-metabolic disorders and mortality. METHODS: PubMed and EMBASE were searched until 5th September 2017 for studies that evaluated the roles of FGF21 levels in cardio-metabolic disorders...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29408673/platelet-derived-microparticles-analysis-techniques-challenges-and-recommendations
#16
REVIEW
Jyotsna Kailashiya
Platelet-derived microparticles (PMP) are nano size fragments (100-1000 nm) released from platelets under various physiological and pathological conditions. PMP are the most abundant microparticles present in human blood. In recent past years PMP have caught attention of many clinicians as well as researchers for being associated with many diseases like cardio-vascular diseases, infections etc; and have emerged as potential biomarkers. Owing to their small size and diverse phenotype, structure and functions, microparticles including PMP render many challenges during sample handling, estimation and characterization...
February 1, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29404353/simultaneous-acute-cardio-cerebral-infarction-is-there-a-consensus-for-management
#17
REVIEW
Oluwaseun A Akinseye, Muhammad Shahreyar, Mark R Heckle, Rami N Khouzam
Acute ischemic stroke (AIS) and acute myocardial infarction (AMI) are both life-threatening medical conditions with narrow therapeutic time-window that carry grave prognosis if not addressed promptly. The acute management of both condition is well documented in the literature, however the management of a simultaneous presentation of both AIS and AMI is unclear. A delayed intervention of one infarcted territory for the other may result in permanent irreversible morbidity or disability, and even death. In addition, the use of antiplatelet and anticoagulants that are inherently part of an AMI management may increase the risk for hemorrhagic conversion associated with intravenous thrombolysis used in AIS, and the use of a thrombolytic in AIS increases the risk of cardiac wall rupture in the setting of an AMI...
January 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29402286/a-review-of-the-experimental-evidence-on-the-toxicokinetics-of-carbon-monoxide-the-potential-role-of-pathophysiology-among-susceptible-groups
#18
REVIEW
Prabjit Barn, Luisa Giles, Marie-Eve Héroux, Tom Kosatsky
BACKGROUND: Acute high level carbon monoxide (CO) exposure can cause immediate cardio-respiratory arrest in anyone, but the effects of lower level exposures in susceptible persons are less well known. The percentage of CO-bound hemoglobin in blood (carboxyhemoglobin; COHb) is a marker of exposure and potential health outcomes. Indoor air quality guidelines developed by the World Health Organization and Health Canada, among others, are set so that CO exposure does not lead to COHb levels above 2...
February 5, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29399333/cardio-oncology-mechanisms-of-cardiovascular-toxicity
#19
REVIEW
Timothy M Markman, Maurie Markman
The therapeutic options available to treat a wide range of malignancies are rapidly increasing. At the same time, the population being treated is aging with more cardiovascular risk factors, comorbid conditions, and associated poor cardiac reserve. Both traditional chemotherapeutic agents (for example, anthracyclines) and newer therapies (for example, targeted tyrosine kinase inhibitors and immune checkpoint inhibitors) have demonstrated profound cardiovascular toxicities. It is important to understand the mechanisms of these toxicities to establish strategies for the prevention and management of complications-arrhythmias, heart failure, and even death...
2018: F1000Research
https://www.readbyqxmd.com/read/29393689/zolpidem-efficacy-and-safety-in-disorders-of-consciousness
#20
Calixto Machado, Mario Estévez, Rafael Rodriguez-Rojas
Sutton and Clauss presented a detailed review about the effectiveness of zolpidem, discussing recoveries from brain damage due to strokes, trauma and hypoxia. A significant finding has been the unexpected and paradoxical increment of brain activity in vegetative state/unresponsive wakefulness syndrome (VS/UWS). On the contrary, zolpidem is considered one of the best sleep inducers in normal subjects. We have studied series of VS/UWS cases after zolpidem intake. We have demonstrated EEG activation, increment of BOLD signal in different brain regions, and an autonomic influence, mainly characterized by a vagolytic chronotropic effect without a significant increment of the vasomotor sympathetic tone...
February 2, 2018: Brain Injury: [BI]
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