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https://www.readbyqxmd.com/read/29229449/treatment-of-persistent-cutaneous-atrophy-after-corticosteroid-injection-with-fat-graft
#1
Nádia Martins, Joaquim Polido-Pereira, Manuel Caneira, João Eurico Fonseca
Subcutaneous fat atrophy and hypopigmentation are potential adverse side effects of local corticosteroid injection that may resolve spontaneously within 1-2 years. This report shows that fat grafting provides a simple, effective and safe correction of corticosteroid induced cutaneous atrophy with very satisfying esthetic and functional results.
December 8, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29218477/safety-and-efficacy-of-facial-fat-grafting-under-local-anesthesia
#2
Xiaorong Ma, Liming Wu, Tianxiang Ouyang, Wenjia Ge, Jingwen Ke
BACKGROUND: Facial fat grafting under local anesthesia has been widely performed in outpatient departments and private settings in China. The present study aimed to evaluate the safety and efficacy of facial fat grafting under local anesthesia. METHOD: A retrospective study was conducted on 155 patients who underwent facial fat grafting. The clinical data were recorded. Preoperative and postoperative two-dimensional images were acquired to evaluate the effect of facial fat grafting on refining facial contouring, rejuvenation as well as deformity reconstruction...
December 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29209151/endoscopic-repair-of-lateral-sphenoid-encephaloceles-a-case-series
#3
Mitchell R Gore
Background: Lateral sphenoid encephaloceles present a surgical challenge. These encephaloceles may be difficult to access given their lateral location and proximity to the neural and vascular structures of the sphenoid floor, pterygopalatine fossa, and lateral and superior sphenoid walls. Additionally, many patients have idiopathic intracranial hypertension, increasing the risk of recurrence. When untreated or undiscovered, these encephaloceles increase the risk of meningitis. Methods: All consecutive endoscopic repairs of lateral sphenoid encephaloceles by a single surgeon from 2012 to 2017 were analyzed for method of repair, complications, and recurrence rate...
2017: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/29207475/function-of-micrornas-in-the-osteogenic-differentiation-and-therapeutic-application-of-adipose-derived-stem-cells-ascs
#4
REVIEW
Walter M Hodges, Frederick O'Brien, Sadanand Fulzele, Mark W Hamrick
Traumatic wounds with segmental bone defects represent substantial reconstructive challenges. Autologous bone grafting is considered the gold standard for surgical treatment in many cases, but donor site morbidity and associated post-operative complications remain a concern. Advances in regenerative techniques utilizing mesenchymal stem cell populations from bone and adipose tissue have opened the door to improving bone repair in the limbs, spine, and craniofacial skeleton. The widespread availability, ease of extraction, and lack of immunogenicity have made adipose-derived stem cells (ASCs) particularly attractive as a stem cell source for regenerative strategies...
December 2, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29207154/adipose-derived-stem-cell-conditioned-medium-attenuates-cisplatin-triggered-apoptosis-in-tongue-squamous-cell-carcinoma
#5
Yu-Jen Chiu, Jai-Sing Yang, Han-Shui Hsu, Chi-Han Tsai, Hsu Ma
Autologous fat grafting procedures have noted a markedly increased frequency, not only for cosmetic purposes, but also for deformities after head and neck cancer and breast cancer surgery. Carcinogenesis is always a major concern in cell therapy-related issues. However, there is no literature discussing this issue in head and neck squamous cell carcinoma patients. To evaluate the interaction of tongue cancer cells and adipose-derived stem cells, we performed a series of in vitro experiments. Our results demonstrated that cisplatin significantly reduced the viabilities of SCC‑25 and CAL‑27 cells in a concentration-dependent manner, but it had low cytotoxicity in cisplatin-resistant CAL‑27 (CAR) cells...
December 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29205140/autologous-fat-transplantation-for-secondary-breast-reconstruction-our-experience
#6
F Simonacci, M P Grieco, N Bertozzi, E Raposio
BACKGROUND: Autologous fat transplantation is used after breast reconstruction to improve the breast profile. There are a variety of different methods used for fat harvesting, preparation, and reinjection. This study describes the specific techniques we used in this series of autologous fat transplantations in breast reconstruction patients and reports their outcomes compared with other studies in the literature. PATIENTS AND METHODS: At the University Hospital of Parma between May 2012 and December 2016, we performed 53 autologous fat transplantations for secondary breast reconstruction patients with an average age of 49 years (range: 34-65 y)...
May 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29202558/malar-region-rejuvenation-through-non-invasive-techniques-hyaluronic-acid-fillers-and-lipofilling
#7
M Pascali, D Quarato, T Marianetti, F Carinci
Contour enhancements of the midface make up a dominant aspect of aesthetic surgery. The goal of midface rejuvenation is to decrease the prominence of grooves and creases as well as to provide volume to atrophied tissue. There are various options, including autologous tissue grafts, allogenic tissue grafts and alloplastic materials. In turn, patients’ needs have led to an increasing trend of less invasive treatments. In the present study, 82 implants were used for midface augmentation in 41 patients (38 women, 3 men) between January 2014 and January 2016...
December 4, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29198704/ischemic-flap-survival-improvement-by-composition-selective-fat-grafting-with-novel-adipose-tissue-derived-product-stromal-vascular-fraction-gel
#8
Pan Zhang, Jingwei Feng, Yunjun Liao, Junrong Cai, Tao Zhou, Mingliang Sun, Jianhua Gao, Kai Gao
BACKGROUND: Flap necrosis due to insufficient blood supply is a common postoperative complication in random pattern flaps. Stem cell therapies have emerged as promising biologics for tissue ischemia. A novel fat derived product, stromal vascular fraction gel (SVF-gel), can be prepared with lipoaspirate through simple mechanical processing, removing only the lipid content. SVF-gel enriches adipose-derived stem cells and potentially beneficial for flap necrosis. METHODS: Nude mice ischemic flaps were treated with human SVF-gel, stromal vascular fraction (SVF) cell suspension or saline (n = 10)...
November 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29195722/autologous-dermis-fat-grafts-as-primary-and-secondary-orbital-transplants-before-rehabilitation-with-artificial-eyes
#9
Sven Holger Baum, Claus Schmeling, Roman Pförtner, Christopher Mohr
OBJECTIVE: The aim of this study was to examine the role of autologous dermis-fat grafts in the reconstruction of orbital soft-tissue defects. PATIENTS: Thirty-six patients (3-84 years) were enrolled in this retrospective study from 2002 to 2014. The dermis-fat graft was primarily transplanted in seven cases, and secondarily in 29 patients. All the patients were evaluated for complications, adequate prosthetic cavity, possibility of artificial eye supply and movement, as well as cosmetic results...
October 26, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29188676/autologous-lipotransfer-versus-stromal-vascular-fraction-enriched-lipoinjection-for-diabetic-foot-wounds-healing-a-pilot-study
#10
G Vicenti, G Solarino, V Pesce, L Moretti, A Notarnicola, M Carrozzo, F Rifino, B Moretti
Chronic ulcers of the lower limbs represent a significant social and economic burden. Diabetes is a strong risk factor for development of chronic lesions. Adult stem cells and growth factors derived from the adipose tissue are among the most promising therapeutic strategies for hard to heal wounds. Fat grafts have been used for several decades to treat soft tissue deformities, but despite its excellent characteristics, the outcome was unpredictable, due to partial necrosis and resorption of the graft. Stem cells’ enrichment of these grafts or their injection into the edges of the ulcers have shown encouraging results in various experimental settings...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29188051/the-science-behind-autologous-fat-grafting
#11
REVIEW
Elisa Bellini, Michele P Grieco, Edoardo Raposio
Introduction: Adipose grafting has undergone significant changes over time. Many different techniques have been followed by trying to improve the quality of the lipoaspirate and the survival of the fat graft after implantation. Material and methods: The purpose of this review is to analyse the historical evolution of the surgical harvesting and implant technique, describing the changes that have brought significant improvements, revolutionizing the aesthetic and functional results obtainable...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29187430/the-yin-and-yang-of-platelet-rich-plasma-in-breast-reconstruction-after-mastectomy-or-lumpectomy-for-breast-cancer
#12
REVIEW
Eleftherios Spartalis, Diamantis I Tsilimigras, Petros Charalampoudis, Georgia-Sofia Karachaliou, Demetrios Moris, Antonios Athanasiou, Michael Spartalis, Vasileios Bolkas, Dimitrios Dimitroulis, Nikolaos Nikiteas
Surgery remains the mainstay of treatment for breast cancer, including complete or partial mastectomy and lumpectomy. Breast reconstruction has gained popularity mainly due to its tremendous impact on the psychological status of the patients. Autologous fat grafting is a well-established method used in cosmetic surgery; however, fat re-absoprtion, fat necrosis, calcifications and oil-cyst formation are some usually encountered complications limiting the efficacy of this approach. Platelet-rich plasma (PRP) has recently been postulated as a promising method for tissue regeneration since it contains high levels of diverse human growth factors...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29179206/hybrid-complexes-of-high-and-low-molecular-weight-hyaluronans-highly-enhance-hascs-differentiation-implication-for-facial-bioremodelling
#13
Antonietta Stellavato, Marcella La Noce, Luisana Corsuto, Anna Virginia Adriana Pirozzi, Mario De Rosa, Gianpaolo Papaccio, Chiara Schiraldi, Virginia Tirino
BACKGROUND/AIMS: Adipose-derived Stem Cells (ASCs) are used in Regenerative Medicine, including fat grafting, recovery from local tissue ischemia and scar remodeling. The aim of this study was to evaluate hyaluronan based gel effects on ASCs differentiation and proliferation. METHODS: Comparative analyses using high (H) and low (L) molecular weight hyaluronans (HA), hyaluronan hybrid cooperative complexes (HCCs), and high and medium cross-linked hyaluronan based dermal fillers were performed...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29176412/prospective-controlled-study-of-chin-augmentation-by-means-of-fat-grafting
#14
Filipe V Basile, Antonio R Basile
BACKGROUND: Although fat grafting is a valuable tool for different areas of plastic surgery, its use in the chin area has never been evaluated. A variety of methods are available for adjusting suboptimal chin morphology, and they each present drawbacks. METHODS: A prospective controlled study was performed to evaluate whether fat grafting increases the chin volume and sagittal projection and to determine the magnitude and nature of the observed changes. Forty-two consecutive patients underwent chin augmentation by means of fat grafting between October of 2014 and January of 2016...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29175445/adipocyte-biology-in-breast-cancer-from-silent-bystander-to-active-facilitator
#15
REVIEW
Junjeong Choi, Yoon Jin Cha, Ja Seung Koo
Adipocytes account for the largest proportion among the cells that comprise breast tissue; therefore, they are considered to be a critical cell type in the tumor microenvironment of breast cancer. In breast cancer, adipocytes are not only found adjacent to cancer cells, but they also play an active role in the entire process of cancer development, progression, metastasis, and treatment response. Factors including the secretion of adipokines such as leptin and adiponectin, as well as autotaxin, interleukin 6, tumor necrosis factor alpha, and hepatic growth factor, metabolic remodeling that supports the growth of breast cancer by transfer of fatty acids to increase mitochondrial β-oxidation, extracellular matrix remodeling and endotrophin production from type IV collagen, and cancer-associated fibroblast phenotype changes have all been implicated in this comprehensive process...
November 21, 2017: Progress in Lipid Research
https://www.readbyqxmd.com/read/29174239/the-efficiency-and-safety-of-the-autologous-fat-graft-in-reconstruction-of-skull-base-defects-after-resection-of-skull-base-meningiomas
#16
Hussam Metwali, Venelin Gerganov, Breno Nery, Ahmed Aly, Rodrigo Avila-Cervantes, Madjid Samii
INTRODUCTION: reconstruction of skull base after resection of skull base meningioma is of paramount importance. We are presenting a safe and effective method of skull base reconstruction METHODS: a retrospective analysis of patients operated for skull base meningioma from 2007 to 2014. We analyzed the surgical technique, efficiency and safety as well as the graft-related complications. RESULTS: Autologous free fat graft had been used in 55 patients. Thirty nine patients had posterior fossa meningioma related to the petrous bone, and sixteen patients had anterior fossa meningiomas related to the paranasal sinuses...
November 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29166348/the-economics-of-prepectoral-breast-reconstruction
#17
REVIEW
Scot Bradley Glasberg
The world of breast reconstruction over the last several years has seen a dramatic shift in focus to discussion and the application of placing tissue expanders and implants back into the prepectoral space. Although this technique failed during the early advent of breast reconstruction, newer technologies such as advances in fat grafting, improved acellular dermal matrices, better methods of assessing breast flap viability, and enhanced implants appear to have set the stage for the resurgence and positive early results seen with this technique...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29166346/options-in-acellular-dermal-matrix-device-assembly
#18
Steven Sigalove
Prepectoral prosthetic breast reconstruction has become increasingly popular during the last several years. Original shortcomings and poor outcomes in the 1970s have been overcome with the use of the bioengineered breast concept-namely, use of improved form stable breast implants, autologous fat grafting, and acellular dermal matrices (ADMs). Careful use of these reconstructive tools combined with improved mastectomy skin flaps has lead to successful early outcomes. Prepectoral breast reconstruction mitigates the animation deformities and muscle tightness previously associated with dual-plane prosthetic breast reconstruction while at the same time producing reproducible and outstanding aesthetic outcomes...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29166342/important-considerations-for-performing-prepectoral-breast-reconstruction
#19
Hani Sbitany
Prepectoral breast reconstruction has emerged as an excellent technique for postmastectomy reconstruction, as it allows for full preservation of a patient's pectoralis major muscle and chest wall function. This reduces pain, eliminates animation deformity, and results in high patient satisfaction. Safely performed prepectoral breast reconstruction requires a careful patient selection process before committing to the procedure, taking into account comorbidities, radiation status, and oncologic criteria such as tumor location and breast cancer stage...
December 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29161346/co-transplantation-of-nanofat-enhances-neovascularization-and-fat-graft-survival-in-nude-mice
#20
Qian Yu, Yizuo Cai, He Huang, Zhenxing Wang, Peng Xu, Xiangsheng Wang, Lu Zhang, Wenjie Zhang, Wei Li
Background: Autologous fat grafting is commonly used for soft-tissue augmentation and reconstruction. However, this technique is limited by a high rate of graft absorption. Thus, approaches to improve fat graft survival that promote neovascularization are of great interest. Nanofat has several beneficial features that may render it more suitable for clinical applications than other stem-cell based approaches. Objectives: We aimed to determine whether nanofat could enhance new vessel formation and improve the long-term retention of fat grafts...
November 17, 2017: Aesthetic Surgery Journal
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