keyword
MENU ▼
Read by QxMD icon Read
search

Oral antidiabetic treatment plus insuline

keyword
https://www.readbyqxmd.com/read/27853981/intensification-of-idegasp-twice-daily-adding-insulin-aspart-vs-switching-to-basal-bolus-exploratory-randomized-trial-in-type-2-diabetes
#1
Wan Mohamaed Wan Bebakar, Louis Chaykin, Malene Lundgren Hersløv, Søren Rasmussen
INTRODUCTION: In a preceding trial comparing two different titration schemes, insulin degludec/insulin aspart (IDegAsp) showed good efficacy for achieving HbA1c <7% when administered twice daily (BID) in patients with uncontrolled type 2 diabetes (T2D). However, poor glycemic control persisted in a minority of patients. The current exploratory trial investigated the efficacy and safety of intensifying IDegAsp BID treatment in these patients by either adding a once-daily (OD) bolus injection of insulin aspart (IAsp) or by switching to a basal-bolus regimen of insulin degludec (IDeg) plus IAsp taken three times a day (TID)...
November 16, 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27667797/glycemic-control-and-safety-in-chinese-patients-with-type-2-diabetes-mellitus-who-switched-from-premixed-insulin-to-insulin-glargine-plus-oral-antidiabetics-a-large-prospective-observational-study
#2
Bo Zhang, Jing Zhao, Wenying Yang
BACKGROUND: In some circumstances, the premixed insulin should be switched to alternative therapy. The effectiveness and safety of switching from premixed insulin to insulin glargine plus oral antidiabetic drugs (OADs) in Chinese patients with type 2 diabetes mellitus (T2DM) have not been clarified, and will be assessed in this study. METHODS: Chinese patients with T2DM (2,013 men and women aged 18 to 75 years) who had received premixed insulin ± OADs for ≥ 3 months with glycated hemoglobin (HbA1c) ≤ 10% were enrolled in a prospective, observational study conducted at 53 hospitals across China...
September 26, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27578616/titration-of-basal-insulin-or-immediate-addition-of-rapid-acting-insulin-in-patients-not-at-target-using-basal-insulin-supported-oral-antidiabetic-treatment-a-prospective-observational-study-in-2202-patients
#3
Thorsten Siegmund, Martin Pfohl, Thomas Forst, Stefan Pscherer, Peter Bramlage, Johannes Foersch, Anja Borck, Jochen Seufert
AIM: Optimal treatment intensification strategies in patients with type-2 diabetes mellitus (T2DM) receiving basal insulin supported oral antidiabetic therapy (BOT) remain controversial. The objective of the present study was to compare outcomes of BOT-intensification by either the uptitration of long-acting insulin glargine or by the immediate addition of a rapid acting insulin analogue (RAIA). METHODS: This was a prospective, observational, 24-week study in T2DM patients with BOT using insulin glargine and baseline glycated hemoglobin (HbA1c) between 7...
August 24, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27222510/prandial-options-to-advance-basal-insulin-glargine-therapy-testing-lixisenatide-plus-basal-insulin-versus-insulin-glulisine-either-as-basal-plus-or-basal-bolus-in-type-2-diabetes-the-getgoal-duo-2-trial
#4
Julio Rosenstock, Bruno Guerci, Markolf Hanefeld, Sandro Gentile, Ronnie Aronson, Francisco J Tinahones, Christine Roy-Duval, Elisabeth Souhami, Marek Wardecki, Jenny Ye, Riccardo Perfetti, Simon Heller
OBJECTIVE: To provide evidence-based options on how to intensify basal insulin, we explored head-to-head prandial interventions in overweight patients with type 2 diabetes inadequately controlled on basal insulin glargine with or without 1-3 oral antidiabetic agents (OADs). RESEARCH DESIGN AND METHODS: Patients were randomized to lixisenatide once daily or insulin glulisine given once or thrice daily, added to glargine, with or without metformin, if HbA1c remained ≥7 to ≤9% (≥53 to ≤75 mmol/mol) after 12 weeks of glargine optimization with OADs other than metformin stopped at the start of optimization...
August 2016: Diabetes Care
https://www.readbyqxmd.com/read/27178047/long-term-safety-and-efficacy-of-fasiglifam-tak-875-a-g-protein-coupled-receptor-40-agonist-as-monotherapy-and-combination-therapy-in-japanese-patients-with-type-2-diabetes-a-52-week-open-label-phase-iii-study
#5
LETTER
K Kaku, K Enya, R Nakaya, T Ohira, R Matsuno
This multicentre, open-label, phase III study investigated the safety and efficacy of the G-protein-coupled receptor 40 agonist fasiglifam. Japanese patients with type 2 diabetes and inadequate glycaemic control despite diet and/or exercise (n = 282), or despite diet and/or exercise plus one oral antidiabetic agent [sulphonylurea (n = 262), rapid-acting insulin secretagogue (n = 124), α-glucosidase inhibitor (n = 141), biguanide (n = 136), thiazolidinedione (n = 139) or dipeptidyl peptidase-4 inhibitor (n = 138)] were randomized to treatment with fasiglifam 25 or 50 mg once daily for 52 weeks...
September 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/26774016/options-for-intensification-of-basal-insulin-in-type-2-diabetes-premeal-insulin-or-short-acting-glp-1-receptor-agonists
#6
P Darmon, D Raccah
Type 2 diabetes is an evolutive disease with a progressive defect of beta-cell insulin secretion. This characteristic points to a need for treatment that takes into account such a natural history. When oral antidiabetic drugs fail to achieve the patient's target HbA1c level, basal insulin treatment is usually initiated and titrated in association with oral drugs to manage fasting hyperglycaemia. Over a period of time, it is enough to simply achieve the HbA1c target. However, when even a good fasting blood glucose level is no longer sufficient to control overall glycaemia, then prandial treatment must be combined with the titrated basal insulin to deal with the postprandial hyperglycaemia responsible for the elevation of HbA1c...
December 2015: Diabetes & Metabolism
https://www.readbyqxmd.com/read/26616594/insulin-initiation-in-insulin-na%C3%A3-ve-korean-type-2-diabetic-patients-inadequately-controlled-on-oral-antidiabetic-drugs-in-real-world-practice-the-modality-of-insulin-treatment-evaluation-study
#7
Sang Soo Kim, In Joo Kim, Yong Ki Kim, Kun Ho Yoon, Ho Young Son, Sung Woo Park, Yeon Ah Sung, Hong Sun Baek
BACKGROUND: The Modality of Insulin Treatment Evaluation (MOTIV) study was performed to provide real-world data concerning insulin initiation in Korean type 2 diabetes mellitus (T2DM) patients with inadequate glycemic control with oral hypoglycemic agents (OHAs). METHODS: This multicenter, non-interventional, prospective, observational study enrolled T2DM patients with inadequate glycemic control (glycosylated hemoglobin [HbA1c] ≥7.0%) who had been on OHAs for ≥3 months and were already decided to introduce basal insulin by their physician prior to the start of the study...
December 2015: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/26583910/empagliflozin-and-linagliptin-combination-therapy-for-treatment-of-patients-with-type-2-diabetes-mellitus
#8
REVIEW
C Triplitt, C Solis-Herrera, E Cersosimo, M Abdul-Ghani, Ralph A Defronzo
INTRODUCTION: Many patients with type 2 diabetes mellitus (T2DM) fail to achieve the desired A1c goal because the antidiabetic medications used do not correct the underlying pathophysiologic abnormalities and monotherapy is not sufficiently potent to reduce the A1c to the 6.5 - 7.0% range. Insulin resistance and islet (beta and alpha) cell dysfunction are major pathophysiologic abnormalities in T2DM. We examine combination therapy with linagliptin plus empagliflozin as a therapeutic approach for the treatment of inadequately controlled T2DM patients...
2015: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/26566714/how-much-is-too-much-outcomes-in-patients-using-high-dose-insulin-glargine
#9
T Reid, L Gao, J Gill, A Stuhr, L Traylor, A Vlajnic, A Rhinehart
BACKGROUND AND OBJECTIVES: Many patients with type 2 diabetes mellitus (T2DM) do not achieve glycaemic control targets on basal insulin regimens. This analysis investigated characteristics, clinical outcomes and impact of concomitant oral antidiabetes drugs (OADs) in patients with T2DM treated with high-dose insulin glargine. METHODS: Patient-level data were pooled from 15 randomised, treat-to-target trials in patients with T2DM treated with insulin glargine ± OADs for ≥ 24 weeks...
January 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/26448574/treatment-patterns-and-glycemic-control-in-older-adults-with-type-2-diabetes-mellitus-receiving-only-oral-antidiabetes-drugs-in-china
#10
MULTICENTER STUDY
Lihua Zhang, Linong Ji, Lixin Guo, Juming Lu, Haoming Tian, Dalong Zhu, Xiaoping Xing, Jian Ping Weng, Weiping Jia
BACKGROUND: Only a few studies have reported the use of oral antidiabetes drugs (OADs) for treating older adults with type 2 diabetes mellitus (T2DM) in China. This study assessed the status of OAD therapy and relevant factors associated with OAD treatment patterns and glycemic control among older patients. PATIENTS AND METHODS: We conducted a noninterventional, observational, cross-sectional, multicenter study, which was initiated by the Chinese Diabetes Society, in which 9,872 outpatients with T2DM were recruited who received OADs only...
November 2015: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/26343931/benefits-of-combination-of-insulin-degludec-and-liraglutide-are-independent-of-baseline-glycated-haemoglobin-level-and-duration-of-type-2-diabetes
#11
H W Rodbard, J B Buse, V Woo, T Vilsbøll, I H Langbakke, K Kvist, S C L Gough
AIM: To evaluate, using post hoc analyses, whether the novel combination of a basal insulin, insulin degludec, and a glucagon-like peptide-1 receptor agonist, liraglutide (IDegLira), was consistently effective in patients with type 2 diabetes (T2D), regardless of the stage of T2D progression. METHODS: Using data from the DUAL I extension [insulin-naïve patients uncontrolled on oral antidiabetic drugs (OADs), n = 1660, 52 weeks] and DUAL II (patients uncontrolled on basal insulin plus OADs, n = 398, 26 weeks) randomized trials, the efficacy of IDegLira was investigated with regard to measures of disease progression stage including baseline glycated haemoglobin (HbA1c), disease duration and previous insulin dose...
January 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/26281972/combination-therapy-with-insulin-glargine-plus-metformin-but-not-insulin-glargine-plus-sulfonylurea-provides-similar-glycemic-control-to-triple-oral-combination-therapy-in-patients-with-type-2-diabetes-uncontrolled-with-dual-oral-agent-therapy
#12
RANDOMIZED CONTROLLED TRIAL
Priscilla Hollander, Danny Sugimoto, Aleksandra Vlajnic, Charles Kilo
AIMS: Evaluate substituting insulin glargine (GLAR) for a thiazolidinedione (TZD) versus adding a third oral antidiabetes drug (OAD) in patients with uncontrolled type 2 diabetes mellitus (T2DM) on TZD+metformin or TZD+sulfonylurea. METHODS: In this multicenter, open-label study, 337 T2DM patients with a glycated hemoglobin A1c (A1C) of 7.5-12.0% despite≥3months of treatment with a TZD plus metformin or a sulfonylurea were randomized to a third OAD (3OAD; metformin or glyburide) or GLAR+1 OAD (metformin or sulfonylurea) with TZD cessation, titrated to a fasting blood glucose≤94mg/dL...
November 2015: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/26044573/access-to-emergency-room-for-hypoglycaemia-in-people-with-diabetes
#13
Elisabetta Salutini, Cristina Bianchi, Massimo Santini, Angela Dardano, Giuseppe Daniele, Giuseppe Penno, Roberto Miccoli, Stefano Del Prato
BACKGROUND: Hypoglycaemia is a major burden of the pharmacological therapy of diabetes and is associated with increased morbidity, mortality and treatment costs. METHODS: We screened all admissions to the emergency room of the Pisa University Hospital from 1 January 2009 to 31 December 2013, selecting individuals with a discharge diagnosis of hypoglycaemia. We retrieved 500 admissions involving adult diabetic patients: age 71 ± 16 years; M/F 50.2/49.8%; 70...
October 2015: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/25952634/glargine-insulin-gliclazide-mr-combination-therapy-is-more-effective-than-premixed-insulin-monotherapy-in-chinese-patients-with-type-2-diabetes-inadequately-controlled-on-oral-antidiabetic-drugs
#14
RANDOMIZED CONTROLLED TRIAL
Jian Zhou, Fenping Zheng, Xiaohui Guo, Huazhang Yang, Muxun Zhang, Haoming Tian, Lixin Guo, Qiang Li, Yifei Mo, Weiping Jia
BACKGROUND: The aim of this study is to compare the efficacy and safety of once-daily insulin glargine plus gliclazide modified release combination therapy versus twice-daily premixed insulin monotherapy in Chinese type 2 diabetic patients insufficiently controlled by oral antidiabetic agents. METHODS: In a 12-week, multicenter, randomized, parallel-group clinical trial, patients with poor glycaemic control (fasting plasma glucose ≥ 7.0 mmol/L and 7.5% < haemoglobin A1c  ≤ 10%) on oral antidiabetic drugs were randomized to the treatment groups for combination therapy (n = 52) or monotherapy (n = 53)...
October 2015: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/25467634/implementation-of-subcutaneous-insulin-protocol-for-non-critically-ill-hospitalized-patients-in-andalusian-tertiary-care-hospitals
#15
María Asunción Martínez-Brocca, Cristóbal Morales, Pilar Rodríguez-Ortega, Beatriz González-Aguilera, Cristina Montes, Natalia Colomo, Gonzalo Piédrola, Mariola Méndez-Muros, Isabel Serrano, Maria Soledad Ruiz de Adana, Alberto Moreno, Ignacio Fernández, Manuel Aguilar, Domingo Acosta, Rafael Palomares
INTRODUCTION: In 2009, the Andalusian Society of Endocrinology and Nutrition designed a protocol for subcutaneous insulin treatment in hospitalized non-critically ill patients (HIP). OBJECTIVE: To analyze implementation of HIP at tertiary care hospitals from the Andalusian Public Health System. METHOD: A descriptive, multicenter study conducted in 8 tertiary care hospitals on a random sample of non-critically ill patients with diabetes/hyperglycemia (n=306) hospitalized for ≥48 hours in 5 non-surgical (SM) and 2 surgical (SQ) departments...
February 2015: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/25195151/efficacy-and-safety-of-basal-insulin-glargine-12-and-24-weeks-after-initiation-in-persons-with-type-2-diabetes-a-pooled-analysis-of-data-from-treatment-arms-of-15-treat-to-target-randomised-controlled-trials
#16
David R Owens, Louise Traylor, Marie-Paule Dain, Wolfgang Landgraf
AIM: Evaluate early (0-12 weeks) and later (12-24 weeks) treatment outcomes in subjects with type 2 diabetes not achieving glycaemic control with oral antidiabetes drugs (OADs). METHODS: Selected data were pooled from 15 randomised, controlled treat-to-target (fasting plasma glucose < 100mg/dL [< 5.6 mmol/L]) trials adding insulin glargine to metformin, a sulphonylurea, or both. Glycaemic and hypoglycaemia parameters, insulin dose, and body weight at weeks 12 and 24 were assessed using individualised subject-level data...
November 2014: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/25166296/the-evaluation-of-clinical-and-cost-outcomes-associated-with-earlier-initiation-of-insulin-in-patients-with-type-2-diabetes-mellitus
#17
COMPARATIVE STUDY
Harry J Smolen, Daniel R Murphy, James C Gahn, Xueting Yu, Bradley H Curtis
BACKGROUND: The treatment for patients with type 2 diabetes mellitus (T2DM) follows a stepwise progression. As a treatment loses its effectiveness, it is typically replaced with a more complex and frequently more costly treatment. Eventually this progression leads to the use of basal insulin typically with concomitant treatments (e.g., metformin, a GLP-1 RA [glucagon-like peptide-1 receptor agonist], a TZD [thiazolidinedione] or a DPP-4i [dipeptidyl peptidase 4 inhibitor]) and, ultimately, to basal-bolus insulin in some forms...
September 2014: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/24944613/insulin-glargine-effectively-achieves-glycemic-control-and-improves-insulin-resistance-in-patients-with-early-type-2-diabetes-that-exhibit-a-high-risk-for-cardiovascular-disease
#18
Jiling Li, Zhengping Feng, Qifu Li, Yan He, Changhong Zhao, Jun He
In the present study, the clinical efficacy and safety of administering insulin glargine to early type 2 diabetes (T2D) mellitus patients with a high risk for cardiovascular disease were assessed. A total of 42 early T2D patients at a high risk for cardiovascular disease were randomly divided into an insulin-glargine group and a standard-care group. The patients in the insulin-glargine group received oral antidiabetic agents plus glargine once a day via a subcutaneous injection. The patients in the standard-care group were administered oral antidiabetic agents according to the diabetic treatment guidelines...
July 2014: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/24866225/preventive-effect-of-monascus-fermented-products-enriched-with-ubiquinones-on-type-2-diabetic-rats-induced-by-a-high-fructose-plus-high-fat-diet
#19
Young-Hee Pyo, Kyung-Won Lee
The aim of the present study was to investigate whether the aqueous extract of Monascus-fermented grains (MFGEs) enriched with ubiquinones (Coenzyme Qs, CoQ9+CoQ10) alleviates high-fructose (60%) plus high-fat (20%) diet (HFD)-induced hyperglycemia and hepatic oxidative stress in male Sprague-Dawley rats. Animals were fed HFD for 16 weeks and orally administered with MFGEs (300 mg/kg/day) or atorvastatin (20 mg/kg/day) for the last 4 weeks of the study. HFD-fed rats exhibited hyperglycemia, hyperinsulinemia, impaired glucose tolerance, and impaired insulin sensitivity...
July 2014: Journal of Medicinal Food
https://www.readbyqxmd.com/read/24843596/present-status-of-insulin-therapy-for-type-2-diabetes-treated-by-general-practitioners-and-diabetes-specialists-in-japan-third-report-of-a-cross-sectional-survey-of-15-652-patients
#20
Keiko Arai, Masahiko Takai, Koichi Hirao, Ikuro Matsuba, Kiyokazu Matoba, Hiroshi Takeda, Akira Kanamori, Mikio Yamauchi, Hisao Mori, Yasuo Terauchi
UNLABELLED: Aims/Introduction:  Insulin therapy is often required to achieve good glycemic control in patients with type 2 diabetes mellitus. However, some providers, particularly general practitioners (GPs), are reluctant to prescribe insulin to their patients. The aim of the present study was to clarify any differences in, as well as any problems associated with, insulin therapy in patients with type 2 diabetes being treated by either a GP or a diabetes specialist in Japan. MATERIALS AND METHODS:   Of 15,652 patients across 721 clinics and hospitals, 15,350 were diagnosed with type 2 diabetes (14,312 by GPs and 1038 by specialists)...
August 20, 2012: Journal of Diabetes Investigation
keyword
keyword
30490
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"