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https://www.readbyqxmd.com/read/28217352/crystal-structure-of-a-chloride-bridged-copper-ii-dimer-piperazine-1-4-dium-bis-di-%C3%AE-chlorido-bis-4-carboxypyridine-2-carboxyl-ato-%C3%AE%C2%BA-2-n-o-2-chlorido-cuprate-ii
#1
Bassey Enyi Inah, Ayi Anyama Ayi, Amit Adhikary
Crystals of a new dimeric chloride-bridged cuprate(II) derived from pyridine-2,4-di-carb-oxy-lic acid were obtained solvothermally in the presence of piperazine and hydro-chloric acid. The crystal structure determination of the title salt, (C4H12N2)[Cu2(C7H4NO4)2Cl4], revealed one of the carboxyl groups of the original pyridine-2,4-di-carb-oxy-lic acid ligand to be protonated, whereas the other is deprotonated and binds together with the pyridine N atom to the Cu(II) atom. The coordination environment of the Cu(II) atom is distorted square-pyramidal...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28217345/fac-aceto-nitrile-tricarbon-yl-di-methyl-carbamodi-thio-ato-%C3%AE%C2%BA-2-s-s-rhenium-i-crystal-structure-and-hirshfeld-surface-analysis
#2
Sang Loon Tan, See Mun Lee, Peter J Heard, Nathan R Halcovitch, Edward R T Tiekink
The title compound, [Re(C3H6NS2)(C2H3N)(CO)3], features an octa-hedrally coordinated Re(I) atom within a C3NS2 donor set defined by three carbonyl ligands in a facial arrangement, an aceto-nitrile N atom and two S atoms derived from a symmetrically coordinating di-thio-carbamate ligand. In the crystal, di-thio-carbamate-methyl-H⋯O(carbon-yl) inter-actions lead to supra-molecular chains along [36-1]; both di-thio-carbamate S atoms participate in intra-molecular methyl-H⋯S inter-actions. Further but weaker aceto-nitrile-C-H⋯O(carbonyl) inter-actions assemble mol-ecules in the ab plane...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28217334/structural-characterization-of-two-tetra-chlorido-zincate-salts-of-4-carb-oxy-1h-imidazol-3-ium-a-salt-hydrate-and-a-co-crystal-salt-hydrate
#3
Sean J Martens, David K Geiger
Imidazole-containing compounds exhibit a myriad of pharmacological activities. Two tetra-chlorido-zincate salts of 4-carb-oxy-1H-imidazol-3-ium, ImHCO2H(+), are reported. Bis(4-carb-oxy-1H-imidazol-3-ium) tetra-chlorido-zincate monohydrate, (C4H5N2O2)2[ZnCl4]·H2O, (I), crystallizes as a monohydrate salt, while bis-(4-carb-oxy-1H-imidazol-3-ium) tetra-chlorido-zincate bis-(1H-imidazol-3-ium-4-carboxyl-ato) monohydrate, (C4H5N2O2)2[ZnCl4]·2C4H4N2O2·H2O, (II), is a co-crystal salt with six residues: two ImHCO2H(+) cations, two formula units of the zwitterionic 1H-imidazol-3-ium-4-carboxyl-ate, ImHCO2, one tetra-chlorido-zincate anion and one water mol-ecule disordered over two sites in a 0...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28196351/fabrication-and-functional-attributes-of-lipidic-nanoconstructs-of-lycopene-an-innovative-endeavour-for-enhanced-cytotoxicity-in-mcf-7-breast-cancer-cells
#4
Ashay Jain, Gajanand Sharma, Varun Kushwah, Kanika Thakur, Gargi Ghoshal, Bhupinder Singh, Sanyog Jain, U S Shivhare, O P Katare
The present study investigates the anticancer efficacy of lycopene loaded lipidic nanostructured particles. With a homogenization-evaporation technique, lycopene loaded solid lipid nanoparticles (LYC-SLNs) were fabricated with different ratios of biocompatible viz. compritol ATO 888 and gelucire, and evaluated for their micromeretics properties, in vitro release, in vitro cytotoxicity, cellular uptake and apoptosis induced in MCF-7 cells. Effects of anticancer potential of LYC-SLNs on the efficacy of methotrexate (MTX), a well-established anticancer agent, was evaluated thereafter...
February 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28187727/cryptotanshinone-enhances-the-effect-of-arsenic-trioxide-in-treating-liver-cancer-cell-by-inducing-apoptosis-through-downregulating-phosphorylated-stat3-in-vitro-and-in-vivo
#5
Li Shen, Guangshun Zhang, Zhaohuan Lou, Guanhua Xu, Guangji Zhang
BACKGROUND: Arsenic trioxide (ATO) is approved for treating terminal-stage liver cancer in China. Cryptotanshinone (CT), a STAT3 inhibitor, has exhibited certain anti-tumor potency; however, the use of CT enhanced ATO for treating liver cancer has not been reported. Here we try to elucidate how CT could enhance the efficacy of ATO for treating liver cancer and its correlation to STAT3 in vitro and in vivo. METHODS: Cell viability of ATO combined with CT was assessed by (1)MTT assay...
February 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28185346/bilateral-malt-lymphoma-of-the-breast
#6
Amalia González López, Javier Del Riego, Amaya Martín, Ato Rodríguez, Franciso Javier, Sonia Piernas, Melcior Sentís
No abstract text is available yet for this article.
February 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28165700/intrinsic-and-stable-conjugation-of-thiolated-mesoporous-silica-nanoparticles-with-radioarsenic
#7
Paul A Ellison, Feng Chen, Shreya Goel, Todd E Barnhart, Robert J Nickles, Onofre T DeJesus, Weibo Cai
The development of new image-guided drug delivery tools to improve the therapeutic efficacy of chemotherapeutics remains an important goal in nanomedicine. Using labeling strategies that involve radioelements that have theranostic pairs of diagnostic positron-emitting isotopes and therapeutic electron-emitting isotopes has promise in achieving this goal and further enhancing drug performance through radiotherapeutic effects. The isotopes of radioarsenic offer such theranostic potential and would allow for the use of positron emission tomography (PET) for image-guided drug delivery studies of the arsenic-based chemotherapeutic arsenic trioxide (ATO)...
February 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28164475/high-performance-supported-ir-oxohydroxide-water-oxidation-electrocatalysts
#8
Cyriac Massue, Verena Pfeifer, Xing Huang, Johannes Noack, Andrey Tarasov, Sebastien Cap, Robert Schlögl
The synthesis of a highly active and yet stable electrocatalyst for the anodic oxygen evolution reaction (OER) remains a major challenge for acidic water splitting on an industrial scale. Addressing this challenge, we obtained an outstanding high-performance OER-electrocatalyst by loading Ir on conductive antimony-doped tin oxide (ATO)-nanoparticles via a microwave (MW)-supported hydrothermal route. The obtained Ir-phase was identified as an XRD-amorphous, highly hydrated Ir(III/IV)-oxohydroxide. In order to identify chemical and structural features responsible for the high activity and exceptional stability under acidic OER-conditions at loadings as low as 20 μg(Ir) cm-2, we used stepwise thermal treatment to gradually alter the XRD-amorphous Ir-phase via dehydroxylation and crystallization of IrO2...
February 5, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28143738/manipulating-pml-sumoylation-via-silencing-ubc9-and-rnf4-regulates-cardiac-fibrosis
#9
Yu Liu, Dan Zhao, Fang Qiu, Ling-Ling Zhang, Shang-Kun Liu, Yuan-Yuan Li, Mei-Tong Liu, Di Wu, Jia-Xin Wang, Xiao-Qing Ding, Yan-Xin Liu, Chang-Jiang Dong, Xiao-Qi Shao, Bao-Feng Yang, Wen-Feng Chu
The promyelocytic leukemia protein (PML) is essential in the assembly of dynamic subnuclear structures called PML nuclear bodies (PML-NBs), which are involved in regulating diverse cellular functions. However, the possibility of PML being involved in cardiac disease has not been examined. In mice undergoing transverse aortic constriction (TAC) and arsenic trioxide (ATO) injection, transforming growth factor β1 (TGF-β1) was upregulated along with dynamic alteration of PML SUMOylation. In cultured neonatal mouse cardiac fibroblasts (NMCFs), ATO, angiotensin II (Ang II), and fetal bovine serum (FBS) significantly triggered PML SUMOylation and the assembly of PML-NBs...
January 28, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28114716/-very-severe-differentiation-syndrome-in-low-risk-acute-promyelocytic-leukemia-a-peril-of-differentiating-therapy
#10
Anna Hecht, Joerg Mezger, Martina Gnadler, Eva Lengfelder
History, examinations and diagnosis A young patient consulted the hospital because of spontaneous hematomas. The combination of pancytopenia and coagulopathy in the blood and the proving cytogenetic and moleculargenetic examinations of the bone marrow lead to the diagnosis of low-risk acute promyelocytic leukemia (APL). Therapy and clinical course During the combination therapy with ATRA and ATO, the patient developed a severe differentiation syndrome and hyperleukocytosis. Management of the condition was only possible due to clinical expertise and massive substitution of blood products and clotting factors...
January 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28112905/a-dual-responsive-nanocomposite-towards-climate-adaptable-solar-modulation-for-energy-saving-smart-windows
#11
Heng Yeong Lee, Yufeng Cai, Shuguang Bi, Yen Nan Liang, Yujie Song, Xiao Matthew Hu
In this work, a novel fully autonomous photothermotropic material made by hybridization of poly (N-isopropylacrylamide) (PNIPAM) hydrogel and antimony tin oxide (ATO) is presented. In this photothermotropic system, the near infrared (NIR) absorbing ATO acts as nano heater to induce the optical switching of the hydrogel. Such new passive smart window is characterized by excellent NIR shielding; photothermally activated switching mechanism, enhanced response speed and solar modulation ability. Systems with 0, 5, 10 and 15 at% Sb doped ATO in PNIPAM were investigated and it was found that PNIPAM/ATO nanocomposite is able to be photothermally activated...
January 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28111878/first-experience-of-the-aml-berlin-frankfurt-m%C3%A3-nster-group-in-pediatric-patients-with-standard-risk-acute-promyelocytic-leukemia-treated-with-arsenic-trioxide-and-all-trans-retinoid-acid
#12
Ursula Creutzig, Michael N Dworzak, Konrad Bochennek, Jörg Faber, Christian Flotho, Norbert Graf, Udo Kontny, Claudia Rossig, Irene Schmid, Arend von Stackelberg, Jans-Enno Mueller, Christine von Neuhoff, Dirk Reinhardt, Nils von Neuhoff
Recently, studies in adults with acute promyelocytic leukemia (APL) showed high cure rates in low-risk patients treated with all-trans retinoid acid (ATRA) and arsenic trioxide (ATO), while toxicities were significantly reduced compared to the standard treatment with ATRA and chemotherapy. Here we report about first experience with 11 pediatric patients with low-risk APL treated with ATRA and ATO. All patients stayed in molecular remission. All suffered from hyperleukocytosis. Two patients experienced reversible severe side effects...
January 23, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28109899/rgd-conjugated-liposome-hollow-silica-hybrid-nanovehicles-for-targeted-and-controlled-delivery-of-arsenic-trioxide-against-hepatic-carcinoma
#13
Weidong Fei, Yan Zhang, Shunping Han, Jiaoyang Tao, Hongyue Zheng, Yinghui Wei, Jiazhen Zhu, Fanzhu Li, Xuanshen Wang
The aim of our study was to construct an Arg-Gly-Asp (RGD)-conjugated liposome-hollow silica hybrid nanovehicle for targeted delivery and controlled release of arsenic trioxide (ATO), whose anti-solid tumor effect was hampered by poor pharmacokinetics and dose-limited toxicity. Hydrophobic interactions were used to attach intact lipid membrane to the surface of chlorodimethyloctadecylsilane-modified hollow mesoporous silica nanoparticles. The prepared nanovehicles (RGD-LP-CHMSN) were characterized for uniform structure (silica core of ∼140nm in diameter and liposomal shell of ∼6nm), comparable drug loading efficiency (6...
January 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28101256/build-the-future-of-science-communication-in-developing-countries-through-systematic-training-of-young-scientists
#14
Thomas K Karikari, Nat Ato Yawson, Emmanuel Quansah
No abstract text is available yet for this article.
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28092839/effect-and-mechanism-of-sorbus-pohuashanensis-hante-hedl-flavonoids-protect-against-arsenic-trioxide-induced-cardiotoxicity
#15
Xiaojin Yu, Zhenyu Wang, Zunpeng Shu, Zhengqing Li, Yuan Ning, Keli Yun, Haina Bai, Ruihai Liu, Wenli Liu
The cardiotoxicity of arsenic trioxide (ATO) limits its clinical application in cancer treatment. Evidences suggest that sorbus has antioxidant activity and its consumption has been linked with improved cardioprotection. In this study, we investigated the cardio-protective effect and mechanisms of Sorbus pohuashanensis (Hante) Hedl. flavonoids (SPF) against ATO in BALB/c mice and H9c2 cells. Eleven major flavonoids were confirmed by ultra-performance liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (UPLC-ESI-Q-TOF-MS)...
January 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28088017/co-delivery-of-ibuprofen-and-gentamicin-from-nanoporous-anodic-titanium-dioxide-layers
#16
Anna Pawlik, Magdalena Jarosz, Karolina Syrek, Grzegorz D Sulka
Although single-drug therapy may prove insufficient in treating bacterial infections or inflammation after orthopaedic surgeries, complex therapy (using both an antibiotic and an anti-inflammatory drug) is thought to address the problem. Among drug delivery systems (DDSs) with prolonged drug release profiles, nanoporous anodic titanium dioxide (ATO) layers on Ti foil are very promising. In the discussed research, ATO samples were synthesized via a three-step anodization process in an ethylene glycol-based electrolyte with fluoride ions...
January 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28087352/engineering-hot-melt-extruded-solid-dispersion-for-controlled-release-of-hydrophilic-drugs
#17
Shuli Zhang, Xuan Meng, Zheng Wang, Aiping Fan, Guocheng Wang, Yanjun Zhao, Yu Tang
It is often challenging to precisely manipulate the release behavior of hydrophilic drugs that is believed to be crucial for a satisfactory therapeutic outcome. The aim of this work was to regulate the dissolution of hydrophilic drug from hot-melt extruded solid dispersion via rational screening of the pore-forming agents. Venlafaxine hydrochloride and Compritol® 888 ATO was selected as the model drug and carrier excipient, respectively. Hydrophilic polyethylene glycol (PEG 6000) and polyvinylpyrolidone (PVP K30) were chosen as the transient pore-forming agents...
January 10, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28076597/oral-health-evaluation-in-special-needs-individuals
#18
Danielle de Moraes Pini, Paula Cristina Gil Ritter Fröhlich, Lilian Rigo
Objective: To identify the prevalence of the main oral problems present in special needs children and to relate the underlying conditions with the clinical and demographic variables. Methods: The study was based on the physical examination of 47 students from the Associação de Pais e Amigos dos Excepcionais diagnosed as Down syndrome, cerebral palsy and intellectual deficit. For data collection, we used a self-administered questionnaire that included indices of dental caries and oral hygiene, Angle classification, malposition of dental groups and oral hygiene habits...
October 2016: Einstein
https://www.readbyqxmd.com/read/28066900/boosting-of-post-exposure-human-t-cell-and-b-cell-recall-responses-in-vivo-by-burkholderia-pseudomallei-related-proteins
#19
Arnone Nithichanon, Louise J Gourlay, Gregory J Bancroft, Manabu Ato, Yoshimasa Takahashi, Ganjana Lertmemongkolchai
Burkholderia pseudomallei is the causative agent of melioidosis, an infectious disease with high incidence and mortality in South East Asia and northern Australia. To date there is no protective vaccine and antibiotic treatment is prolonged and not always effective. Most people living in endemic areas have been exposed to the bacteria and have developed some immunity, which may have helped to prevent disease. Here, we used a humanized mouse model (hu-PBL-SCID), reconstituted with human peripheral blood mononuclear cells from seropositive donors, to illustrate the potential of three known antigens (FliC, OmpA and N-PilO2) for boosting both T-cell and B-cell immune responses...
January 9, 2017: Immunology
https://www.readbyqxmd.com/read/28061438/combination-of-arsenic-trioxide-and-everolimus-rad001-synergistically-induces-both-autophagy-and-apoptosis-in-prostate-cancer-cells
#20
Sheng Tai, Lingfan Xu, Ming Xu, Ligang Zhang, Yangyang Zhang, Kaipin Zhang, Li Zhang, Chaozhao Liang
The inhibitor of PI3K-AKT-mTOR pathway, such as Rad001, has not shown therapeutic efficacy as a single agent in prostate cancer. Arsenic trioxide induces the autophagic pathway in prostate cancer cells. We identified Arsenic trioxide can synergize with Rad001 to induce cytotoxicity of prostate cancer cells. Moreover, we identified synergistic induction of autophagy and apoptosis as the underlying mechanism. This enhanced autophagic cell death is accompanied by increased Beclin1 mRNA stability as well as upregulation of ATG5-ATG12 conjugate, Beclin1, and LC3-2...
January 4, 2017: Oncotarget
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