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https://www.readbyqxmd.com/read/28303559/-thoracic-outlet-syndrome
#1
Sven Seifert, Pavel Sebesta, Marian Klenske, Mirko Esche
Introduction Thoracic outlet syndrome (TOS) is one of the most extensively discussed diagnoses. There is neither a clear and homogenous clinical presentation nor an accepted definition. The term describes a complex of symptoms and complaints caused by the compression of nerves and vascular structures at one of the three defined constrictions of the upper thoracic aperture. Methods Based on a comprehensive literature review, this article presents the etiology, epidemiology and clinical diagnostics as well as the possibilities and outcomes of surgical treatment...
February 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28301033/polycyclic-aromatic-hydrocarbons-produced-by-electrocautery-smoke-and-the-use-of-personal-protective-equipment-1
#2
Caroline Vieira Claudio, Renata Perfeito Ribeiro, Júlia Trevisan Martins, Maria Helena Palucci Marziale, Maria Cristina Solci, José Carlos Dalmas
Objective: analyze the concentration of polycyclic aromatic hydrocarbons in electrocautery smoke in operating rooms and the use of personal protective equipment by the intraoperative team when exposed to hydrocarbons. Method: exploratory and cross-sectional field research conducted in a surgery center. Gases were collected by a vacuum suction pump from a sample of 50 abdominal surgeries in which an electrocautery was used. A form was applied to identify the use of personal protective equipment...
March 2, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28292316/efficacy-safety-and-tolerance-of-imidocarb-dipropionate-versus-atovaquone-or-buparvaquone-plus-azithromycin-used-to-treat-sick-dogs-naturally-infected-with-the-babesia-microti-like-piroplasm
#3
Rocío Checa, Ana Montoya, Nieves Ortega, José Luis González-Fraga, Adrián Bartolomé, Rosa Gálvez, Valentina Marino, Guadalupe Miró
BACKGROUND: Piroplasmosis caused by the Babesia microti-like piroplasm (Bml) is increasingly being detected in dogs in Europe. Sick dogs show acute disease with severe anaemia associated with thrombocytopenia with a poor response to current available drugs. This study assesses the safety and tolerance of three treatments and compares their efficacy over a full year of follow up in dogs naturally infected with Bml. METHODS: Fifty-nine dogs naturally infected with Bml were randomly assigned to a treatment group: imidocarb dipropionate (5 mg/kg SC, 2 doses 14 d apart) (IMI); atovaquone (13...
March 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28278714/cucurbitacin-b-synergistically-enhances-the-apoptosis-inducing-effect-of-arsenic-trioxide-by-inhibiting-stat3-phosphorylation-in-lymphoma-ramos-cells
#4
Xiuli Ding, Jiadong Chi, Xue Yang, Jian Hao, Chang Liu, Cuihong Zhu, Xiaodong Wang, Xiaohui Liu, Yangyang Niu, Wei Ji, Dan Chen, Xiongzhi Wu
Arsenic trioxide (ATO) is a classic apoptosis-inducing agent used to treat acute promyelocytic leukemia. However, the therapeutic effect of ATO is limited in lymphoma, which resists apoptosis possibly due to inappropriate activation of STAT3. Therefore, combination of ATO and STAT3 inhibitor may be a potential strategy to treat lymphoma. Dramatically, Cucurbitacin B (CuB), an effective component of the dichloromethane extraction from Trichosanthes kirilowii Maxim, synergistically eliminated the apoptosis resistance of Burkitt's lymphoma Ramos cells to ATO by inhibiting the phosphorylation of STAT3, followed in turn by downregulation of Bcl-2 and upregulation of Bax...
February 20, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28276286/arsenic-trioxide-and-all-trans-retinoic-acid-selectively-exert-synergistic-cytotoxicity-against-flt3-itd-aml-cells-via-co-inhibition-of-flt3-signaling-pathways
#5
Li-Na Wang, Yan-Lai Tang, Yin-Chuan Zhang, Zu-Han Zhang, Xiao-Jian Liu, Zhi-Yong Ke, Yu Li, Hui-Zhen Tan, Li-Bin Huang, Xue-Qun Luo
FLT3-ITD mutations occur in approximately 30% of acute myeloid leukemia (AML) and are associated with a poor outcome. Currently available FLT3 inhibitors have in vitro but limited clinical activity in FLT3-ITD AML. Reports have shown that an arsenic trioxide (ATO)/all-trans-retinoic acid (ATRA) combination improves prognosis in acute promyelocytic leukemia, especially with FLT3-ITD, and ATO or ATRA alone enhances apoptosis in FLT3-ITD AML cells treated with FLT3 inhibitors, providing a rationale to investigate the role of ATO/ATRA in FLT3-ITD AML...
March 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28261759/dihydroartemisinin-sensitizes-human-lung-adenocarcinoma-a549-cells-to-arsenic-trioxide-via-apoptosis
#6
Hongyu Chen, Shiyan Gu, Huangmei Dai, Xinyang Li, Zunzhen Zhang
Recent studies have shown that arsenic trioxide (ATO) is an effective anti-cancer drug for treatment of acute promyelocytic leukemia and other types of human cancer. However, we have found that lung cancer cells constantly develop a high level of resistance to ATO. In this study, we have explored a possibility of combination of dihydroartemisinin (DHA) and ATO treatments to reduce ATO resistance of lung cancer cells. We determined the combinatory effects of DHA and ATO on cytotoxicity of human lung adenocarcinoma (A549) cells...
March 6, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28260074/atorvastatin-prolongs-the-lifespan-of-radiation%C3%A2-induced-reactive-oxygen-species-in-pc-3-prostate-cancer-cells-to-enhance-the-cell-killing-effect
#7
Hao Yu, Shao-Qian Sun, Xiao-Bin Gu, Wen Wang, Xian-Shu Gao
Studies have reported that atorvastatin (ATO) may increase the radiosensitivity of malignant cells. However, the influence of ATO on reactive oxygen species (ROS) levels before and after irradiation has not been fully illustrated. In the present study, radiosensitivity was evaluated by a clonogenic assay and a cell survival curve and cell apoptosis was measured by flow cytometry. ROS were detected by a laser scanning confocal microscope and flow cytometry with a DCFH-DA probe. NADPH oxidases (NOXs) and superoxide dismutase (SOD) proteins were detected by immunoblotting, and total SOD activity was measured using an SOD kit...
February 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28254430/anti-tumor-activity-of-pi3k-%C3%AE-inhibitor-in-hematologic-malignant-cells-shedding-new-light-on-resistance-to-idelalisib
#8
Davood Bashash, Ava Safaroghli-Azar, Maryam Dadashi, Majid Safa, Majid Momeny, Seyed H Ghaffari
Genetic and laboratory experiments have brought remarkable advances in management of human malignancies, which not only revolutionized the understanding of the disease, but also led to development of novel and effective targeted therapies against specific deregulated pathways. This study aimed to investigate anti-cancer effects of Idelalisib, a potent PI3K-δ inhibitor, in a panel of hematological cell lines. The resulting data showed that Idelalisib decreased cell survival in all the tested cell lines; however, as compared to NB4, viability of other cell lines, irrespective of their molecular characteristics or even the compensatory activation of MEK/ERK pathway, was inhibited at higher concentrations...
February 22, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28245381/-effect-of-arsenic-trioxide-on-k562-cell-proliferation-and-its-mechanism
#9
Yuan Wang, Jie Yang, Jie Li, Rui-Cang Wang, Jun Yuan, Yan Li, Su-Yun Wang, Chao Wang, Hong-Ling Hao
OBJECTIVE: To investigate the molecular mechanism of arsenic trioxide(ATO) inhibiting K562 cell proliferation, and explore the new targets for treating chronic myeloid leukemia(CML). METHODS: human CML cell line K562 cells were cultured in vitro, and were treated with different concentrations of ATO; MTT was used to detect the cell proliferation; flow cytometry(FCM) was used to determine cell apoptosis, cell cycle and the expression of CD44; Transcriptional levels of β-catenin and cyclin D1 were assayed by RT-PCR...
February 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28241849/metformin-potentiates-the-effect-of-arsenic-trioxide-suppressing-intrahepatic-cholangiocarcinoma-roles-of-p38-mapk-erk3-and-mtorc1
#10
Sunbin Ling, Haiyang Xie, Fan Yang, Qiaonan Shan, Haojiang Dai, Jianyong Zhuo, Xuyong Wei, Penghong Song, Lin Zhou, Xiao Xu, Shusen Zheng
BACKGROUND: Arsenic trioxide (ATO) is commonly used in the treatment of acute promyelocytic leukemia (APL), but does not benefit patients with solid tumors. When combined with other agents or radiation, ATO showed treatment benefits with manageable toxicity. Previously, we reported that metformin amplified the inhibitory effect of ATO on intrahepatic cholangiocarcinoma (ICC) cells more significantly than other agents. Here, we investigated the chemotherapeutic sensitization effect of metformin in ATO-based treatment in ICC in vitro and in vivo and explored the underlying mechanisms...
February 28, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28238736/evolutionary-variation-in-neural-gene-expression-in-the-developing-sense-organs-of-the-crustacean-daphnia-magna
#11
Marleen Klann, Angelika Stollewerk
Arthropods have numerous sense organs, which are adapted to their habitat. While some sense organs are similar in structure and function in all arthropod groups, structural differences in functionally related sense organs have been described, as well as the absence of particular sense organ subtypes in individual arthropod groups. Here we address the question of how the diverse structures of arthropod sense organs have evolved by analysing the underlying molecular developmental processes in a crustacean, an arthropod group that has been neglected so far...
April 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28217352/crystal-structure-of-a-chloride-bridged-copper-ii-dimer-piperazine-1-4-dium-bis-di-%C3%AE-chlorido-bis-4-carboxypyridine-2-carboxyl-ato-%C3%AE%C2%BA-2-n-o-2-chlorido-cuprate-ii
#12
Bassey Enyi Inah, Ayi Anyama Ayi, Amit Adhikary
Crystals of a new dimeric chloride-bridged cuprate(II) derived from pyridine-2,4-di-carb-oxy-lic acid were obtained solvothermally in the presence of piperazine and hydro-chloric acid. The crystal structure determination of the title salt, (C4H12N2)[Cu2(C7H4NO4)2Cl4], revealed one of the carboxyl groups of the original pyridine-2,4-di-carb-oxy-lic acid ligand to be protonated, whereas the other is deprotonated and binds together with the pyridine N atom to the Cu(II) atom. The coordination environment of the Cu(II) atom is distorted square-pyramidal...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28217345/fac-aceto-nitrile-tricarbon-yl-di-methyl-carbamodi-thio-ato-%C3%AE%C2%BA-2-s-s-rhenium-i-crystal-structure-and-hirshfeld-surface-analysis
#13
Sang Loon Tan, See Mun Lee, Peter J Heard, Nathan R Halcovitch, Edward R T Tiekink
The title compound, [Re(C3H6NS2)(C2H3N)(CO)3], features an octa-hedrally coordinated Re(I) atom within a C3NS2 donor set defined by three carbonyl ligands in a facial arrangement, an aceto-nitrile N atom and two S atoms derived from a symmetrically coordinating di-thio-carbamate ligand. In the crystal, di-thio-carbamate-methyl-H⋯O(carbon-yl) inter-actions lead to supra-molecular chains along [36-1]; both di-thio-carbamate S atoms participate in intra-molecular methyl-H⋯S inter-actions. Further but weaker aceto-nitrile-C-H⋯O(carbonyl) inter-actions assemble mol-ecules in the ab plane...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28217334/structural-characterization-of-two-tetra-chlorido-zincate-salts-of-4-carb-oxy-1h-imidazol-3-ium-a-salt-hydrate-and-a-co-crystal-salt-hydrate
#14
Sean J Martens, David K Geiger
Imidazole-containing compounds exhibit a myriad of pharmacological activities. Two tetra-chlorido-zincate salts of 4-carb-oxy-1H-imidazol-3-ium, ImHCO2H(+), are reported. Bis(4-carb-oxy-1H-imidazol-3-ium) tetra-chlorido-zincate monohydrate, (C4H5N2O2)2[ZnCl4]·H2O, (I), crystallizes as a monohydrate salt, while bis-(4-carb-oxy-1H-imidazol-3-ium) tetra-chlorido-zincate bis-(1H-imidazol-3-ium-4-carboxyl-ato) monohydrate, (C4H5N2O2)2[ZnCl4]·2C4H4N2O2·H2O, (II), is a co-crystal salt with six residues: two ImHCO2H(+) cations, two formula units of the zwitterionic 1H-imidazol-3-ium-4-carboxyl-ate, ImHCO2, one tetra-chlorido-zincate anion and one water mol-ecule disordered over two sites in a 0...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28196351/fabrication-and-functional-attributes-of-lipidic-nanoconstructs-of-lycopene-an-innovative-endeavour-for-enhanced-cytotoxicity-in-mcf-7-breast-cancer-cells
#15
Ashay Jain, Gajanand Sharma, Varun Kushwah, Kanika Thakur, Gargi Ghoshal, Bhupinder Singh, Sanyog Jain, U S Shivhare, O P Katare
The present study investigates the anticancer efficacy of lycopene loaded lipidic nanostructured particles. With a homogenization-evaporation technique, lycopene loaded solid lipid nanoparticles (LYC-SLNs) were fabricated with different ratios of biocompatible viz. compritol ATO 888 and gelucire, and evaluated for their micromeretics properties, in vitro release, in vitro cytotoxicity, cellular uptake and apoptosis induced in MCF-7 cells. Effects of anticancer potential of LYC-SLNs on the efficacy of methotrexate (MTX), a well-established anticancer agent, was evaluated thereafter...
April 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28187727/cryptotanshinone-enhances-the-effect-of-arsenic-trioxide-in-treating-liver-cancer-cell-by-inducing-apoptosis-through-downregulating-phosphorylated-stat3-in-vitro-and-in-vivo
#16
Li Shen, Guangshun Zhang, Zhaohuan Lou, Guanhua Xu, Guangji Zhang
BACKGROUND: Arsenic trioxide (ATO) is approved for treating terminal-stage liver cancer in China. Cryptotanshinone (CT), a STAT3 inhibitor, has exhibited certain anti-tumor potency; however, the use of CT enhanced ATO for treating liver cancer has not been reported. Here we try to elucidate how CT could enhance the efficacy of ATO for treating liver cancer and its correlation to STAT3 in vitro and in vivo. METHODS: Cell viability of ATO combined with CT was assessed by (1)MTT assay...
February 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28185346/bilateral-malt-lymphoma-of-the-breast
#17
Amalia González López, Javier Del Riego, Amaya Martín, Ato Rodríguez, Franciso Javier, Sonia Piernas, Melcior Sentís
No abstract text is available yet for this article.
February 10, 2017: Breast Journal
https://www.readbyqxmd.com/read/28165700/intrinsic-and-stable-conjugation-of-thiolated-mesoporous-silica-nanoparticles-with-radioarsenic
#18
Paul A Ellison, Feng Chen, Shreya Goel, Todd E Barnhart, Robert J Nickles, Onofre T DeJesus, Weibo Cai
The development of new image-guided drug delivery tools to improve the therapeutic efficacy of chemotherapeutics remains an important goal in nanomedicine. Using labeling strategies that involve radioelements that have theranostic pairs of diagnostic positron-emitting isotopes and therapeutic electron-emitting isotopes has promise in achieving this goal and further enhancing drug performance through radiotherapeutic effects. The isotopes of radioarsenic offer such theranostic potential and would allow for the use of positron emission tomography (PET) for image-guided drug delivery studies of the arsenic-based chemotherapeutic arsenic trioxide (ATO)...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28164475/high-performance-supported-ir-oxohydroxide-water-oxidation-electrocatalysts
#19
Cyriac Massue, Verena Pfeifer, Xing Huang, Johannes Noack, Andrey Tarasov, Sebastien Cap, Robert Schlögl
The synthesis of a highly active and yet stable electrocatalyst for the anodic oxygen evolution reaction (OER) remains a major challenge for acidic water splitting on an industrial scale. Addressing this challenge, we obtained an outstanding high-performance OER-electrocatalyst by loading Ir on conductive antimony-doped tin oxide (ATO)-nanoparticles via a microwave (MW)-supported hydrothermal route. The obtained Ir-phase was identified as an XRD-amorphous, highly hydrated Ir(III/IV)-oxohydroxide. In order to identify chemical and structural features responsible for the high activity and exceptional stability under acidic OER-conditions at loadings as low as 20 μg(Ir) cm-2, we used stepwise thermal treatment to gradually alter the XRD-amorphous Ir-phase via dehydroxylation and crystallization of IrO2...
February 5, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28143738/manipulating-pml-sumoylation-via-silencing-ubc9-and-rnf4-regulates-cardiac-fibrosis
#20
Yu Liu, Dan Zhao, Fang Qiu, Ling-Ling Zhang, Shang-Kun Liu, Yuan-Yuan Li, Mei-Tong Liu, Di Wu, Jia-Xin Wang, Xiao-Qing Ding, Yan-Xin Liu, Chang-Jiang Dong, Xiao-Qi Shao, Bao-Feng Yang, Wen-Feng Chu
The promyelocytic leukemia protein (PML) is essential in the assembly of dynamic subnuclear structures called PML nuclear bodies (PML-NBs), which are involved in regulating diverse cellular functions. However, the possibility of PML being involved in cardiac disease has not been examined. In mice undergoing transverse aortic constriction (TAC) and arsenic trioxide (ATO) injection, transforming growth factor β1 (TGF-β1) was upregulated along with dynamic alteration of PML SUMOylation. In cultured neonatal mouse cardiac fibroblasts (NMCFs), ATO, angiotensin II (Ang II), and fetal bovine serum (FBS) significantly triggered PML SUMOylation and the assembly of PML-NBs...
March 1, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
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