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https://www.readbyqxmd.com/read/29934696/sample-size-estimation-for-heterogeneous-growth-curve-models-with-attrition
#1
Guillermo Vallejo, Manuel Ato, M Paula Fernández, Pablo E Livacic-Rojas
In this study, two approaches were employed to calculate how large the sample size needs to be in order to achieve a desired statistical power to detect a significant group-by-time interaction in longitudinal intervention studies-a power analysis method, based on derived formulas using ordinary least squares estimates, and an empirical method, based on restricted maximum likelihood estimates. The performance of both procedures was examined under four different scenarios: (a) complete data with homogeneous variances, (b) incomplete data with homogeneous variances, (c) complete data with heterogeneous variances, and (d) incomplete data with heterogeneous variances...
June 22, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29892554/incident-adverse-events-following-therapy-for-acute-promyelocytic-leukemia
#2
Peter Geon Kim, Kelly Bridgham, Evan C Chen, Mahesh K Vidula, Olga Pozdnyakova, Andrew M Brunner, Amir T Fathi
The use of all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) with or without cytotoxic chemotherapy is highly effective in acute promyelocytic leukemia (APL) but incident chronic adverse events (AEs) after initiation of therapy are not well understood. We retrospectively analyzed adult patients with newly diagnosed APL from 2004 through 2014 to identify incident AEs following treatment and contributing risk factors. Cardiac and neurologic AEs were more common and characterized in detail. Cardiac AEs such as the development of coronary artery disease (CAD), arrhythmias, and heart failure had a cumulative incidence of 6...
2018: Leukemia Research Reports
https://www.readbyqxmd.com/read/29892279/introduction-of-human-flt3-l-and-gm-csf-into-humanized-mice-enhances-the-reconstitution-and-maturation-of-myeloid-dendritic-cells-and-the-development-of-foxp3-cd4-t-cells
#3
Ryutaro Iwabuchi, Shota Ikeno, Mie Kobayashi-Ishihara, Haruko Takeyama, Manabu Ato, Yasuko Tsunetsugu-Yokota, Kazutaka Terahara
Two cytokines, fms-related tyrosine kinase 3 ligand (Flt3-L) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are considered to be the essential regulators of dendritic cell (DC) development in vivo . However, the combined effect of Flt3-L and GM-CSF on human DCs has not been evaluated in vivo . In this study, we, therefore, aimed at evaluating this using a humanized mouse model. Humanized non-obese diabetic/SCID/Jak3null (hNOJ) mice were constructed by transplanting hematopoietic stem cells from human umbilical cord blood into newborn NOJ mice, and in vivo transfection (IVT) was performed by hydrodynamic injection-mediated gene delivery using plasmids encoding human Flt3-L and GM-CSF...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29887842/hiv-ltr-driven-antisense-rna-by-itself-has-regulatory-function-and-may-curtail-virus-reactivation-from-latency
#4
Mie Kobayashi-Ishihara, Kazutaka Terahara, Javier P Martinez, Makoto Yamagishi, Ryutaro Iwabuchi, Christian Brander, Manabu Ato, Toshiki Watanabe, Andreas Meyerhans, Yasuko Tsunetsugu-Yokota
Latently infected T lymphocytes are an important barrier toward eliminating a persistent HIV infection. Here we describe an HIV-based recombinant fluorescent-lentivirus referred to as "rfl-HIV" that enables to analyze sense and antisense transcription by means of fluorescence reporter genes. This model virus exhibited similar transcriptional and functional properties of the antisense transcript as observed with a wild type HIV, and largely facilitated the generation of latently-infected T cells clones...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29875156/design-implementation-and-evaluation-of-a-school-insecticide-treated-net-distribution-program-in-cross-river-state-nigeria
#5
Angela Acosta, Emmanuel Obi, Richmond Ato Selby, Iyam Ugot, Matthew Lynch, Mark Maire, Kassahun Belay, Abidemi Okechukwu, Uwem Inyang, Jessica Kafuko, George Greer, Lilia Gerberg, Megan Fotheringham, Hannah Koenker, Albert Kilian
BACKGROUND: In 2013, the World Health Organization recommended distribution through schools, health facilities, community health workers, and mass campaigns to maintain coverage with insecticide-treated nets (ITNs). We piloted school distribution in 3 local government areas (LGAs) of Cross River State, Nigeria. METHODS: From January to March 2011, all 3 study sites participated in a mass ITN campaign. Baseline data were collected in June 2012 (N=753 households) and school distribution began afterward...
June 6, 2018: Global Health, Science and Practice
https://www.readbyqxmd.com/read/29867492/salvianolic-acid-a-ameliorates-arsenic-trioxide-induced-cardiotoxicity-through-decreasing-cardiac-mitochondrial-injury-and-promotes-its-anticancer-activity
#6
Jing-Yi Zhang, Min Wang, Rui-Ying Wang, Xiao Sun, Yu-Yang Du, Jing-Xue Ye, Gui-Bo Sun, Xiao-Bo Sun
Arsenic trioxide (ATO) is used as a therapeutic agent in the treatment of acute promyelocytic leukemia (APL). The therapeutic use of arsenic is limited due to its severe cardiovascular side effects. The cardio-protective effect of salvianolic acid A (Sal A) against ATO cardiotoxicity has been reported. However, the distinct role of the mitochondria in the cardio-protection of Sal A is not understood. The aim of this study was to determine whether Sal A preconditioning protects against ATO-induced heart injury by maintaining cardiac mitochondrial function and biogenesis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29862538/improved-long-term-survival-in-all-sanz-risk-patients-of-newly-diagnosed-acute-promyelocytic-leukemia-treated-with-a-combination-of-retinoic-acid-and-arsenic-trioxide-based-front-line-therapy
#7
Yinjun Lou, Ying Lu, Zhijuan Zhu, Yafang Ma, Shanshan Suo, Yungui Wang, Dong Chen, Hongyan Tong, Wenbin Qian, Haitao Meng, Wenyuan Mai, Wenjun Yu, Weilai Xu, Lei Wang, Liping Mao, Renzhi Pei, Jie Jin
Limited data was available for long-term follow-up in newly diagnosed acute promyelocytic leukemia (APL) patients treated with all-trans-retinoic acid (ATRA) plus intravenously arsenic trioxide (ATO)-based front-line therapy. The aim of this work was to retrospectively analyze the long-term survival rate and frequency of therapy-related myeloid neoplasia (t-MN) occurring in a large cohort of APL patients. A total of 760 newly diagnosed patients with APL between January 1999 and May 2016 were evaluated. The early death rate was 9...
June 3, 2018: Hematological Oncology
https://www.readbyqxmd.com/read/29850043/bis-4-meth-oxy-chalcone-4-ethyl-thio-semi-carbazon-ato-%C3%AE%C2%BA-2-n-1-s-zinc-ii-crystal-structure-and-hirshfeld-surface-analysis
#8
Ming Yueh Tan, Karen A Crouse, Thahira B S A Ravoof, Mukesh M Jotani, Edward R T Tiekink
The title ZnII complex, [Zn(C19 H20 N3 OS)2 ] {systematic name: bis-[( N -ethyl- N '-{( Z )-[(2 E )-3-(4-meth-oxy-phen-yl)-1-phenyl-prop-2-en-1-yl-idene]amino}-carb-am-im-id-o-yl)sulfanido]zinc(II)}, features a tetra-hedrally coordinated ZnII ion within an N2 S2 donor set provided by two N , S -chelating thio-semicarbazone anions. The resulting five-membered Zn,C,N2 ,S chelate rings adopt different conformations, i.e . almost planar and an envelope with the Zn atom being the flap atom. The configuration about the imine bond within the chelate ring is Z but those about the exocyclic imine and ethyl-ene bonds are E ...
February 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29845392/clinical-pharmacokinetics-and-safety-profile-of-single-agent-arsenic-trioxide-by-continuous-slow-rate-infusion-in-patients-with-newly-diagnosed-acute-promyelocytic-leukemia
#9
Chunlu Gao, Shuang Hu, Meihua Guo, Xin Hai, Jin Zhou
PURPOSE: This study evaluated pharmacokinetics (PK) and safety profiles of single agent arsenic trioxide (ATO, As2 O3 ) administrated as continuous slow-rate infusion in patients with newly diagnosed acute promyelocytic leukemia. PATIENTS AND METHODS: Patients received 0.16 mg/kg ATO per day. ATO was given for 40 min infusion on the first day followed by 18-20 h daily at a very slow rate with infusion speed of 8 drips/min. During the first week, plasma samples were collected immediately before next administration on each day, and 0...
May 29, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29844323/naturally-occurring-a-loss-of-a-giant-plasmid-from-mycobacterium-ulcerans-subsp-shinshuense-makes-it-non-pathogenic
#10
Kazue Nakanaga, Yoshitoshi Ogura, Atsushi Toyoda, Mitsunori Yoshida, Hanako Fukano, Nagatoshi Fujiwara, Yuji Miyamoto, Noboru Nakata, Yuko Kazumi, Shinji Maeda, Tadasuke Ooka, Masamichi Goto, Kazunari Tanigawa, Satoshi Mitarai, Koichi Suzuki, Norihisa Ishii, Manabu Ato, Tetsuya Hayashi, Yoshihiko Hoshino
Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), a WHO-defined neglected tropical disease. All Japanese BU causative isolates have shown distinct differences from the prototype and are categorized as M. ulcerans subspecies shinshuense. During repeated sub-culture, we found that some M. shinshuense colonies were non-pigmented whereas others were pigmented. Whole genome sequence analysis revealed that non-pigmented colonies did not harbor a giant plasmid, which encodes elements needed for mycolactone toxin biosynthesis...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29805662/downregulation-of-ros1-enhances-the-therapeutic-efficacy-of-arsenic-trioxide-in-acute-myeloid-leukemia-cell-lines
#11
Jun Li
The present study investigated the function of ROS proto-oncogene 1 receptor tyrosine kinase (ROS1) in regulating the migration and proliferation of acute myeloid leukemia (AML) cells through Wnt/β-catenin signaling, and in arsenic trioxide (ATO) treatment. The migration and proliferation of multiple ROS1-silenced leukemic cell lines was assessed, and the expression levels of proteins associated with Wnt/β-catenin signaling were determined using western blot analysis. Compared with the AML control cells, ROS1-knockdown cells exhibited increased migration and proliferation, and the significant downregulation of β-catenin expression...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29802839/oxytocin-receptor-antagonist-atosiban-impairs-consolidation-but-not-reconsolidation-of-contextual-fear-memory-in-rats
#12
Payman Rasise Abdullahi, Sharaf Eskandarian, Ali Ghanbari, Ali Rashidy-Pour
There is increasing evidence that oxytocin is involved in learning and memory process. This study investigated the effects of blockade of oxytocin receptors using the selective oxytocin receptor antagonist atosiban (ATO) on contextual fear memory consolidation and reconsolidation in male rats. Post-training injections of different doses of ATO (1, 10, 100 or 1000 µg/kg) impaired the 48 h retention performance in a dose-dependent manner. The same doses of ATO following memory reactivation did not impair subsequent expression of contextual fear memories which formed under low or high shock intensities and tested 24 h or one week following memory reactivation...
May 23, 2018: Brain Research
https://www.readbyqxmd.com/read/29799888/-suicide-risk-associated-with-bullying-and-depression-in-high-school
#13
Raúl Sandoval Ato, Martín A Vilela Estrada, Christian R Mejia, José Caballero Alvarado
INTRODUCTION: Suicide risk is increasingly common among children and adolescents. There are no current and local studies of this reality in northern Peru. The objective was to determine whether suici de risk was associated with bullying and depression in high school students. PATIENTS AND METHOD: An analytical cross-sectional study was carried out in a city in northern Peru, using validated surveys to measure suicide risk, bullying and depression. Statical association data were obtained using generali zed linear models...
April 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29772714/modulating-chemosensitivity-of-tumors-to-platinum-based-antitumor-drugs-by-transcriptional-regulation-of-copper-homeostasis
#14
REVIEW
Yu-Hsuan Lai, Chin Kuo, Macus Tien Kuo, Helen H W Chen
Platinum (Pt)-based antitumor agents have been effective in treating many human malignancies. Drug importing, intracellular shuffling, and exporting-carried out by the high-affinity copper (Cu) transporter ( hCtr1 ), Cu chaperone (Ato x1), and Cu exporters (ATP7A and ATP7B), respectively-cumulatively contribute to the chemosensitivity of Pt drugs including cisplatin and carboplatin, but not oxaliplatin. This entire system can also handle Pt drugs via interactions between Pt and the thiol-containing amino acid residues in these proteins; the interactions are strongly influenced by cellular redox regulators such as glutathione...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772273/effect-of-formulation-and-process-variables-on-lipid-based-sustained-release-tablets-via-continuous-twin-screw-granulation-a-comparative-study
#15
Venkata Raman Kallakunta, Roshan Tiwari, Sandeep Sarabu, Suresh Bandari, Michael A Repka
The current study's aim is to prepare lipid based sustained release tablets via a twin-screw granulation technique and compare those dosage forms with conventional techniques, namely wet granulation and direct compression. The granules were successfully manufactured in a single-step, continuous twin-screw granulation process with a low proportion of binder (Klucel™ EF, HPC SSL) using Compritol® 888 ATO, Precirol® ATO 5 and Geleol™ as sustained release agents. The granules prepared showed good flow characteristics and compaction properties...
May 14, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29770610/arsenic-trioxide-coated-stent-is-an-endothelium-friendly-drug-eluting-stent
#16
Yinping Zhao, Ruolin Du, Tian Zhou, Dongchuan Yang, Yuhua Huang, Yi Wang, Junli Huang, Xiaoyi Ma, Fugui He, Juhui Qiu, Guixue Wang
An ideal vascular stent would both inhibit in-stent restenosis (ISR) and promote rapid re-endothelialization. In the current study, the performance of arsenic trioxide (ATO)-drug eluting stent (AES) is compared with the bare metal stent, poly-lactic-co-glycolic acid-coating metal stent, and rapamycin-drug eluting stent (RES). In vivo AES is shown to prevent neointimal hyperplasia more efficiently than the others when implanted into the carotid arteries of rabbits. Moreover, AES promotes endothelial cells proliferation and re-endothelialization more quickly than RES...
May 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29767511/low-dose-arsenic-trioxide-modulates-the-differentiation-of-mouse-embryonic-stem-cells
#17
Wenlin Yuan, Jun Chen, Hongren Huang, Zhihui Cai, Qinjie Ling, Feng Huang, Zhi Huang
Arsenic (As) is a well-known environmental pollutant,while arsenic trioxide (ATO) has been proven to be an effective treatment for acute promyelocytic leukemia, however, the mechanism underlying its dual effects is not fully understood.Embryonic stem cells (ESCs) appear properties of stemness and serve as a popular model to investigate epigenetic modifiers includingenvironmental pollutants.Herein, the effect of low dose ATO on differentiation were evaluatedin vitro using a mouse ESCs (mESCs) cell line, CGR8...
May 16, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29765716/synthesis-and-crystal-structure-of-deca-carbon-yl-%C3%AE-3-3-7-di-thia-nonane-1-9-di-thiol-ato-bis-%C3%AE-2-propane-1-3-di-thiol-ato-nickel-ii-tetra-iron-ii-di-chloro-methane-disolvate
#18
Gan Ren, Ge Sang
The title compound,, [Fe4 Ni(C3 H6 S2 )2 (C7 H14 S4 )(CO)10 ]·2CH2 Cl2 , is reported as a biomimic model for the active site of [FeFe]-hydrogenases. Bis(2-mercaptoeth-yl)-1,3-propane-dithio ether nickel(II) was firstly introduced into [Fe2 (C3 H6 S2 )(CO)5 ] as an S-containing ligand. It coordinates with two [Fe2 (C3 H6 S2 )(CO)5 ] groups, and a five-metal core complex is formed. The Fe2 S2 core is in a butterfly conformation. The Fe-Fe distances in the [Fe2 (C3 H6 S2 )(CO)5 ] groups are 2.5126 (6) and 2...
March 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29751708/-preparation-and-in-vitro-evaluation-of-arsenic-trioxide-glioma-targeting-drug-delivery-system-loaded-by-pamam-dendrimers-co-modified-with-rgdyc-and-peg
#19
An-Hao Huang, Shun-Ping Han, Yan-Ping Lu, Rui Ma, Hang-Sheng Zheng, Fan-Zhu Li
Arsenic trioxide (ATO) is an effective component of traditional Chinese medicine arsenic. The existing studies have shown its good inhibition and apoptosis ability on a variety of tumours. However, its toxicity and difficulties in the permeability into the blood brain barrier (BBB) has the limitation in the application of glioma treatment. Polyamide-amine dendrimer (PAMAM) is a synthetic polymer with many advantages, such as a good permeability, stability and biocompatibility. Additionally, the 5th generation of PAMAM is an ideal drug carrier due to its three-dimensional structure...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29750941/ultrasonic-assisted-magnetic-dispersive-solid-phase-microextraction-for-pre-concentration-of-serotonin-norepinephrine-reuptake-inhibitor-drugs
#20
Mahdi Ghorbani, Mahmoud Chamsaz, Mohsen Aghamohammadhasan, Alireza Shams
A simple and sensitive ultrasonic assisted magnetic dispersive solid phase microextraction method (UAMDSPME) coupled with high performance liquid chromatography was developed to determine serotonin-norepinephrine reuptake inhibitor drugs including duloxetine (DUL), venlafaxine (VEN) and atomoxetine (ATO) in human urine, river water and well water samples. A novel and efficient SPME sorbent, magnetic p-Phenylenediamine functionalized reduced graphene oxide Quantum Dots@ Ni nanocomposites (MrGOQDs-PD@ Ni), was prepared and applied for extraction of the analytes...
May 8, 2018: Analytical Biochemistry
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