keyword
https://read.qxmd.com/read/38492712/postmenopausal-women-with-normal-bmd-who-have-fracture-have-deteriorated-bone-microarchitecture-a-prospective-analysis-from-the-ofely-study
#21
JOURNAL ARTICLE
E Sornay-Rendu, F Duboeuf, R D Chapurlat
Most postmenopausal women who sustain fragility fracture (Fx) have their areal bone mineral density (aBMD) above the osteoporosis threshold. A sizeable proportion of them have normal aBMD. The aim of this study was to prospectively investigate the association of fragility Fx with bone microarchitecture (MA) assessed by high resolution peripheral computed tomography (HR-pQCT) in postmenopausal women without low BMD. At the 14th annual follow-up of the OFELY study, we have measured bone MA at the distal radius and tibia with HR-pQCT in addition to areal BMD with DXA, in 586 postmenopausal women...
March 14, 2024: Bone
https://read.qxmd.com/read/38488245/comparison-of-two-surgical-approaches-for-periacetabular-osteotomy-a-retrospective-study-of-patients-with-developmental-dysplasia-of-the-hip
#22
JOURNAL ARTICLE
Haitao Guo, Hongfu Jin, Yuanyuan Cheng, Yufeng Mei, Hui Li, Djandan Tadum Arthur Vithran, Shuguang Liu, Jun Li
OBJECTIVE: Given the intricate challenges and potential complications associated with periacetabular osteotomy (PAO) for developmental dysplasia of the hip (DDH). Our study aimed to compare the clinical and imaging benefits and drawbacks of two surgical approaches, the modified Stoppa combined iliac spine approach and the modified Smith-Peterson approach, for treating PAO and to provide guidance for selecting clinical approaches. METHODS: A retrospective analysis of 56 patients with 62 DDHs was conducted from June 2018 to January 2022...
March 15, 2024: Orthopaedic Surgery
https://read.qxmd.com/read/38485241/association-between-fat-mass-and-obesity-related-transcript-polymorphisms-and-osteoporosis-phenotypes
#23
JOURNAL ARTICLE
Krisel De Dios, Ngoc Huynh, Thach S Tran, Jacqueline R Center, Tuan V Nguyen
BACKGROUND: Common variants in the fat mass and obesity-related transcript (FTO) gene are related to body mass index and obesity, suggesting its potential association with bone mineral density (BMD) and fracture risk. This study sought to define the association between FTO gene variants and the following phenotypes: (1) BMD; (2) bone loss; and (3) fracture risk. METHODS: This analysis was based on the Dubbo Osteoporosis Epidemiology Study that included 1,277 postmenopausal women aged ≥60 years living in Dubbo, Australia...
February 2024: Journal of Bone Metabolism
https://read.qxmd.com/read/38484114/genome-wide-association-study-of-osteoporosis-identifies-genetic-risk-and-interactions-with-dash-diet-and-sugar-sweetened-beverages-in-a-hispanic-cohort-of-older-adults
#24
JOURNAL ARTICLE
Liam E Fouhy, Chao-Qiang Lai, Laurence D Parnell, Katherine L Tucker, José M Ordovás, Sabrina E Noel
BACKGROUND: Osteoporosis (OP) and low bone mass can be debilitating and costly conditions if not acted on quickly. This disease is also difficult to diagnose as symptoms develop unnoticed until fracture occurs. Therefore, gaining understanding of the genetic risk associated with these conditions could be beneficial for healthcare professionals in early detection and prevention. METHODS: The Boston Puerto Rican Osteoporosis (BPROS) study, an ancillary study to the Boston Puerto Rican Health Study (BPRHS), collected information regarding bone and bone health...
March 14, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38483640/poor-lumbar-spine-coordination-in-acute-low-back-pain-predicts-persistent-long-term-pain-and-disability
#25
JOURNAL ARTICLE
Mansour Abdullah Alshehri, Wolbert van den Hoorn, David M Klyne, Jaap H van Dieën, Jacek Cholewicki, Paul W Hodges
PURPOSE: Sitting balance on an unstable surface requires coordinated out-of-phase lumbar spine and provides sufficient challenge to expose quality of spine control. We investigated whether the quality of spine coordination to maintain balance in acute low back pain (LBP) predicts recovery at 6 months. METHODS: Participants in an acute LBP episode (n = 94) underwent assessment of sitting balance on an unstable surface. Seat, hip and spine (lower lumbar, lumbar, upper lumbar, thoracic) angular motion and force plate data were recorded...
March 14, 2024: European Spine Journal
https://read.qxmd.com/read/38478461/the-influence-of-seated-postures-and-anthropometry-on-lap-belt-fit-in-vehicle-occupants-a-3d-computed-tomography-study
#26
JOURNAL ARTICLE
Yoshihiko Tanaka, Houtatsu Shu, Yuqing Zhao, Koji Mizuno, Minoru Yamada, Yoichi Yokoyama, Yoshitake Yamada, Masahiro Jinzaki
OBJECTIVE: In vehicle frontal collisions, it is crucial that the lap belt is designed to engage with the anterior superior iliac spine (ASIS) of occupants for a reliable restraint. This study aims to understand the influence of different seated postures on the geometrical relationship of the seat belt and the pelvis for various occupants using 3D upright and supine computed tomography (CT) systems. METHODS: The 3D shapes of bones and soft tissues around the pelvis were acquired through a CT scan for 30 participants...
March 13, 2024: Traffic Injury Prevention
https://read.qxmd.com/read/38477819/a-skeleton-in-a-huff-insights-in-etiologies-of-osteosclerosis
#27
JOURNAL ARTICLE
Zhaozhao Chen, Folake Akanbi, David R Lucas, David M Walton, Erika Benavides, Fabiana N Soki, Geoffrey W Siegel, Laurie K McCauley, Gregory A Clines
A 30-year-old man developed right lower leg pain and a palpable solid mass. Radiographic imaging revealed a periosteal reaction with an exostotic mass arising from the right distal fibula. Generalized skeletal osteosclerosis with periosteal reaction was discovered on a radiographic skeletal survey. A biopsy of the right fibular mass revealed reactive woven bone. The patient was referred to a metabolic bone disease clinic, where laboratory values were consistent with secondary hyperparathyroidism and increased bone turnover...
January 17, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477812/osteoporosis-presenting-during-pregnancy-and-lactation-wait-and-reassess
#28
JOURNAL ARTICLE
Christopher S Kovacs
Two months after her first pregnancy, a 35-year-old exclusively breastfeeding woman bent to move her baby in the car seat and experienced sudden, severe pain from five spontaneous vertebral compression fractures. Genomic screen was negative but she had mild ankylosing spondylitis previously well controlled on Etanercept. She was vegetarian with a high phytate intake. A lactation consultant had advised her to pump and discard milk between feeds, such that she believed she produced twice as much milk as her baby ingested...
March 4, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477810/association-of-white-matter-hyperintensities-with-bone-mineral-density-incident-fractures-and-falls-in-the-uk-biobank-cohort
#29
JOURNAL ARTICLE
Lishan Cai, Xingyu Lv, Xiang Li, Xuan Wang, Hao Ma, Yoriko Heianza, Lu Qi, Tao Zhou
Osteoporosis is the most common metabolic bone disease in the world, which increases the healthcare service burden. Recent studies have linked higher white matter hyperintensities (WMH) to reduced bone mineral density (BMD), increasing the risk of fractures and falls in older adults. However, limited evidence exists regarding the dose-response relationship between WMH and bone health in a larger and younger population. Our study aimed to examine the association of WMH volume with BMD, incident fractures and falls, with a particular focus on dose-response relationship with varying levels of WMH volume...
February 21, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477796/sedentary-behavior-does-not-predict-low-bmd-nor-fracture-population-based-canadian-multicentre-osteoporosis-study-camos
#30
JOURNAL ARTICLE
Sigríður Lára Guðmundsdóttir, Claudie Berger, Heather Macdonald, Jonathan D Adachi, Wilma M Hopman, Stephanie M Kaiser, Christopher S Kovacs, Kenneth Shawn Davison, Suzanne N Morin, David Goltzman, Jerilynn C Prior
Sedentary behavior (SB) or sitting is associated with multiple unfavorable health outcomes. Bone tissue responds to imposed gravitational and muscular strain with there being some evidence suggesting a causal link between SB and poor bone health. However, there are no population-based data on the longitudinal relationship between SB, bone change and incidence of fragility fractures. This study aimed to examine the associations of sitting/sedentary behavior (defined as daily sitting time), areal bone mineral density (BMD by dual energy X-ray absorptiometry) and incident low trauma (fragility) osteoporotic fractures (excluding hands, feet, face and head)...
January 24, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38477751/equivalence-trial-of-proposed-denosumab-biosimilar-gp2411-and-reference-denosumab-in-postmenopausal-osteoporosis-the-rosalia-study
#31
JOURNAL ARTICLE
Sławomir Jeka, Eva Dokoupilová, Alan Kivitz, Paweł Żuchowski, Barbara Vogg, Natalia Krivtsova, Susmit Sekhar, Samik Banerjee, Arnd Schwebig, Johann Poetzl, Jean-Jacques Body, Richard Eastell
Denosumab is a monoclonal antibody used to reduce risk of fractures in osteoporosis. ROSALIA was a multicenter, double-blind, randomized, integrated phase I/phase III study comparing the efficacy, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and safety of proposed biosimilar denosumab GP2411 with reference denosumab (REF-DMAb) (Prolia®; Amgen). Postmenopausal women with osteoporosis were randomized 1:1 to two 60 mg doses of GP2411 or REF-DMAb, one at study start and one at Week 26...
January 29, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38476964/kinematic-changes-of-the-trunk-and-lower-limbs-during-voluntary-lateral-sway-postural-control-in-adults-with-low-back-pain
#32
JOURNAL ARTICLE
Zhengquan Chen, Oren Tirosh, Jia Han, Roger Adams, Doa El-Ansary, Adrian Pranata
Introduction: Voluntary lateral weight shifting is essential for gait initiation. However, kinematic changes during voluntary lateral weight shifting remain unknown in people with low back pain (LBP). This study aims to explore the differences in kinematics and muscle activation when performing a voluntary lateral weight shifting task between patients with LBP and asymptomatic controls without pain. Methods: Twenty-eight participants volunteered in this study (14 in both the LBP group and the control group)...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38475669/the-canal-bone-ratio-a-novel-indicator-for-opportunistic-osteoporosis-screening-in-adult-spinal-deformity-patients-through-radiographs
#33
JOURNAL ARTICLE
Yunsheng Wang, Tong Tong, Jiali Zhang, Dechao Miao, Feng Wang, Linfeng Wang
STUDY DESIGN: Retrospective diagnostic study. OBJECTIVES: To evaluate the utility of quantitative assessment of bone density using proximal femoral morphological parameters based on full-spine X-rays. SUMMARY OF BACKGROUND DATA: CT and MRI are commonly utilized methods for opportunistic assessment of bone density. However, there is currently a lack of means to quantitatively assess bone density in adult spinal deformity (ASD) patients through radiographs...
March 13, 2024: Spine
https://read.qxmd.com/read/38474288/molecular-mechanisms-linking-osteoarthritis-and-alzheimer-s-disease-shared-pathways-mechanisms-and-breakthrough-prospects
#34
REVIEW
Idiongo Okon Umoh, Helton Jose Dos Reis, Antonio Carlos Pinheiro de Oliveira
Alzheimer's disease (AD) is a progressive neurodegenerative disease mostly affecting the elderly population. It is characterized by cognitive decline that occurs due to impaired neurotransmission and neuronal death. Even though deposition of amyloid beta (Aβ) peptides and aggregation of hyperphosphorylated TAU have been established as major pathological hallmarks of the disease, other factors such as the interaction of genetic and environmental factors are believed to contribute to the development and progression of AD...
March 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472450/hip-spine-relationship-clinical-evidence-and-biomechanical-issues
#35
REVIEW
Alberto Di Martino, Giuseppe Geraci, Matteo Brunello, Claudio D'Agostino, Giorgio Davico, Cristina Curreli, Francesco Traina, Cesare Faldini
The hip-spine relationship is a critical consideration in total hip arthroplasty (THA) procedures. While THA is generally successful in patient, complications such as instability and dislocation can arise. These issues are significantly influenced by the alignment of implant components and the overall balance of the spine and pelvis, known as spinopelvic balance. Patients with alteration of those parameters, in particular rigid spines, often due to fusion surgery, face a higher risk of THA complications, with an emphasis on complications in instability, impingement and dislocation...
March 12, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38472341/techniques-for-registration-of-myoelectric-activity-of-women-s-pelvic-floor-muscles-a-scoping-review
#36
REVIEW
Josepha Karinne de Oliveira Ferro, Andrea Lemos, Alessandra Carolina de Santana Chagas, Alexa Alves de Moraes, Ana Izabela Sobral de Oliveira-Souza, Daniella Araújo de Oliveira
INTRODUCTION AND HYPOTHESIS: Surface electromyography is commonly applied to measure the electrophysiological activity of the neuromuscular system. However, there is no consensus regarding the best protocol to assess pelvic floor muscles. METHODS: A scoping literature review was carried out in six databases, using MeSH descriptors. It included studies with electromyographic assessment in adult women presenting or not with pelvic floor dysfunction. The results were presented in categories to contribute to the development of a protocol considering the most used parameters for non-invasive assessment of myoelectric activity of pelvic floor muscles...
March 12, 2024: International Urogynecology Journal
https://read.qxmd.com/read/38472286/comparing-risk-assessment-methods-for-work-related-musculoskeletal-disorders-with-in-vivo-joint-loads-during-manual-materials-handling
#37
JOURNAL ARTICLE
Christopher Brandl, Alwina Bender, Tim Schmachtenberg, Jörn Dymke, Philipp Damm
The validity of observational methods in ergonomics is still challenging research. Criterion validity in terms of concurrent validity is the most commonly studied. However, studies comparing observational methods with biomechanical values are rare. Thus, the aim of this study is to compare the Ovako Working Posture Analysing System (OWAS) and the Rapid Entire Body Assessment (REBA) with in vivo load measurements at hip, spine, and knee during stoop and squat lifting of 14 participants. The results reveal that OWAS and REBA action levels (AL) can distinguish between different in vivo load measurements during manual lifting...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38469810/-stuck-in-the-middle-the-missing-lumbosacral-link-in-total-hip-arthroplasty
#38
JOURNAL ARTICLE
Christopher M Scanlon, Thomas Christensen, Thomas Bieganowski, Weston Buehring, Morteza Meftah, Matthew S Hepinstall
INTRODUCTION: Spinopelvic mobility drives functional acetabular position, influencing dislocation risk after total hip arthroplasty (THA). Patients have been described as "stuck sitting" or "stuck standing" based on pelvic tilt (PT). We hypothesised that some patients are "stuck in the middle," meaning their PT changes minimally from sitting to standing - increasing their risk of dislocation. METHODS: We reviewed 195 patients with standing and sitting whole body radiographs prior to THA...
March 12, 2024: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://read.qxmd.com/read/38460219/impact-of-combined-lumbar-spine-fusion-and-total-hip-arthroplasty-on-spine-pelvis-and-hip-kinematics-during-a-sit-to-stand-task
#39
JOURNAL ARTICLE
Shawn M Robbins, Evangelos Tyrpenou, Soomin Lee, Patrick Ippersiel, John Antoniou
Lumbar fusion is a risk factor for hip dislocation following total hip arthroplasty (THA). The objective was to compare joint/segment angles during sit-stand-sit in participants that had a THA with and without a lumbar fusion. The secondary objective was to compare pain, physical function, disability, and quality of life. This cross-sectional study includes participants that had THA and lumbar fusion (THA-fusion; n = 12) or THA only (THA-only; n = 12). Participants completed sit-stand-sit trials...
March 3, 2024: Journal of Electromyography and Kinesiology
https://read.qxmd.com/read/38458487/proton-pump-inhibitors-bone-and-phosphocalcic-metabolism
#40
JOURNAL ARTICLE
Cécile Philippoteaux, Julien Paccou, Emmanuel Chazard, Cortet Bernard
Proton pump inhibitors (PPIs) are widely used for acid-related gastrointestinal disorders; however, concerns have arisen about their prolonged and inappropriate use. Although generally considered safe, recent evidence has linked PPI use with an increased risk of kidney disease, stomach cancer, pneumonia, dementia, cardiovascular events and potential bone health problems. This systematic review examines the effects of PPIs on bone health, including osteoporosis and changes in phosphocalcic and magnesium metabolism, through a comprehensive analysis of the recent literature...
March 6, 2024: Joint, Bone, Spine: Revue du Rhumatisme
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