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https://www.readbyqxmd.com/read/29333031/a-case-of-multifocal-eosinophilic-granuloma-involving-spine-and-pelvis-in-a-young-adult-a-radiopathological-correlation
#1
Santosh Rai, H B Sridevi, Radha R Pai, Pulastya Sanyal
We present a case of multiple osteolytic lesions in a 28-year-old adult who presented with headache, back pain, and hip pain of 6 months. There was no history of localized swelling or rise of temperature, no history of weight loss or evening rise of temperature. On examination, there were no focal neurological deficits. Routine laboratory investigations, including total leukocyte counts, differential leukocyte counts, hemoglobin, and platelet counts, were within normal limits. There was a borderline elevation of erythrocyte sedimentation rate...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29324877/impact-of-extra-articular-pathologies-on-groin-pain-an-arthroscopic-evaluation
#2
Mitsunori Kaya
PURPOSE: For patients who have anterior hip pain evaluated by Patrick's test and tenderness at Scarpa's triangle, we perform periarticular debridement based on the hypothesis that extra-articular pathologies are responsible for the hip pain. The purpose of this study was to categorize the endoscopic extra-articular findings and to evaluate the clinical significance of periarticular pathologies in anterior hip pain. METHODS: Arthroscopic findings of 77 patients who underwent periarthritic debridement were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29322706/osteoporosis-in-postmenopausal-females-with-primary-knee-osteoarthritis-in-a-vitamin-d-deficient-population
#3
Pooja Dhaon, Siddharth Kumar Das, Ragini Srivastava, Akash Asthana, Girdhar Agarwal
Aim and Objective: To find prevalence of osteoporosis (OP) in postmenopausal females with primary knee osteoarthritis (OA) in India, where there is widespread Vitamin D deficiency (VDD). Material and Methods: 75 postmenopausal women (PMW) fulfilling ACR criteria for Knee OA between 40 - 60 years of age, having OA grade 2 or more as per Kellgren Lawrence grade on anterior- posterior radiograph of the right knee were enrolled. 34 PMW of the same age with normal right knee radiograph were taken as controls...
November 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29310921/does-patients-perception-of-leg-length-after-total-hip-arthroplasty-correlate-with-anatomical-leg-length
#4
Jean Y Lazennec, Dominique Folinais, Caroline Florequin, Aidin E Pour
BACKGROUND: This study assessed the correlation among the patients' perception of the leg length discrepancy (LLD) after total hip arthroplasty (THA) and the anatomical and functional leg length, pelvic and knee alignments, and foot height. METHODS: Patients without significant spinal pathology or previous spine or lower extremity surgery who underwent primary THA (101 patients) were evaluated using EOS images obtained in standing position. All 3-dimensional measures were evaluated and compared for the repeatability and reproducibility and correlation with patients' perception of leg length...
December 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29310920/total-hip-arthroplasty-patients-with-fixed-spinopelvic-alignment-are-at-higher-risk-of-hip-dislocation
#5
Christina I Esposito, Kaitlin M Carroll, Peter K Sculco, Douglas E Padgett, Seth A Jerabek, David J Mayman
BACKGROUND: Sitting radiographs have been used as a pre-operative tool to plan patient-specific total hip arthroplasty (THA) component position that would improve hip stability. Previous work has demonstrated that spinal mobility may impact functional acetabular position when seated. We sought to determine whether patients who dislocate following THA have different sitting spinopelvic alignment or acetabular component orientation compared to patients who did not dislocate. METHODS: A consecutive series of 1000 patients underwent post-operative low-dose biplanar spine-to-ankle lateral radiographs in standing and sitting positions 1 year following THA...
December 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29310418/improvements-in-osteoporosis-testing-and-care-are-found-following-the-wide-scale-implementation-of-the-ontario-fracture-clinic-screening-program-an-interrupted-time-series-analysis
#6
Dorcas E Beaton, Muhammad Mamdani, Hong Zheng, Susan Jaglal, Suzanne M Cadarette, Earl R Bogoch, Joanna E M Sale, Rebeka Sujic, Ravi Jain
We evaluated a system-wide impact of a health intervention to improve treatment of osteoporosis after a fragility fracture. The intervention consisted of assigning a screening coordinator to selected fracture clinics to identify, educate, and follow up with fragility fracture patients and inform their physicians of the need to evaluate bone health. Thirty-seven hospitals in the province of Ontario (Canada) were assigned a screening coordinator. Twenty-three similar hospitals were control sites. All hospitals had orthopedic services and handled moderate-to-higher volumes of fracture patients...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29309382/the-prevalence-and-treatment-of-hip-dysplasia-in-prader-willi-syndrome-pws
#7
Anastasiya A Trizno, Alexander S Jones, Patrick M Carry, Gaia Georgopoulos
BACKGROUND: Prader-Willi syndrome (PWS) is a genetic disorder with multisystem involvement. There are a number of associated orthopaedic manifestations, the most recognized of which is scoliosis. The aim of this study was to assess the prevalence of hip dysplasia and to investigate its treatment in patients with PWS. METHODS: Following IRB approval, all patients seen at our institution's Prader-Willi multidisciplinary clinic were retrospectively reviewed. Only patients with an ultrasound, anteroposterior (AP) spine, AP abdomen, AP hip radiograph, and/or skeletal survey were included in the study...
January 5, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29307281/intermittent-fasting-protects-against-the-deterioration-of-cognitive-function-energy-metabolism-and-dyslipidemia-in-alzheimer-s-disease-induced-estrogen-deficient-rats
#8
Bae Kun Shin, Suna Kang, Da Sol Kim, Sunmin Park
Intermittent fasting may be an effective intervention to protect against age-related metabolic disturbances, although it is still controversial. Here, we investigated the effect of intermittent fasting on the deterioration of the metabolism and cognitive functions in rats with estrogen deficiency and its mechanism was also explored. Ovariectomized rats were infused with β-amyloid (25-35; Alzheimer's disease) or β-amyloid (35-25, Non-Alzheimer's disease; normal cognitive function) into the hippocampus. Each group was randomly divided into two sub-groups: one with intermittent fasting and the other fed ad libitum: Alzheimer's disease-ad libitum, Alzheimer's disease-intermittent fasting, Non-Alzheimer's disease-ad libitum, and Non-Alzheimer's disease-intermittent fasting...
January 1, 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29304057/long-chain-omega-3-polyunsaturated-fatty-acid-dietary-intake-is-positively-associated-with-bone-mineral-density-in-normal-and-osteopenic-spanish-women
#9
Jesus Lavado-García, Raul Roncero-Martin, Jose M Moran, Maria Pedrera-Canal, Ignacio Aliaga, Olga Leal-Hernandez, Sergio Rico-Martin, Maria L Canal-Macias
The regular consumption of long-chain omega-3 polyunsaturated fatty acids (LCO3-PUFAs) results in general health benefits. The intake of LCO3-PUFAs has been reported to contribute to bone metabolism. We aimed to investigate the relationships between dietary intakes of LCO3-PUFAs and bone mineral density (BMD) in Spanish women aged 20-79 years old. A total of 1865 female subjects (20-79 years old) were enrolled, and lumbar (L2, L3, L3 and total spine), hip (femoral neck (FN), femoral trochanter (FT) and Ward's triangle (WT)) bone mineral density (BMD) were measured by dual energy X-ray absorptiometry (DXA)...
2018: PloS One
https://www.readbyqxmd.com/read/29296931/bone-disease-in-monoclonal-gammopathy-of-undetermined-significance-results-from-a-screened-population-based-study
#10
Sigrun Thorsteinsdottir, Sigrun H Lund, Ebba K Lindqvist, Marianna Thordardottir, Gunnar Sigurdsson, Rene Costello, Debra Burton, Hlif Steingrimsdottir, Vilmundur Gudnason, Gudny Eiriksdottir, Kristin Siggeirsdottir, Tamara B Harris, Ola Landgren, Sigurdur Y Kristinsson
Previous studies have shown that individuals with monoclonal gammopathy of undetermined significance (MGUS) have an increased risk of fractures, although the underlying mechanisms remain unknown. Our aim was to analyze bone mineral density (BMD), bone volume, and risk of fractures among individuals with MGUS. We performed a screening using the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study cohort, consisting of 5764 elderly individuals, identifying 300 individuals with MGUS, and 275 with light-chain MGUS...
December 26, 2017: Blood Advances
https://www.readbyqxmd.com/read/29287118/serum-n-propeptide-of-collagen-iia-piianp-as-a-marker-of-radiographic-osteoarthritis-burden
#11
Hikmat N Daghestani, Joanne M Jordan, Jordan B Renner, Michael Doherty, A Gerry Wilson, Virginia B Kraus
OBJECTIVE: Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum levels of type IIA procollagen amino terminal propeptide (sPIIANP), a biomarker representing type II collagen synthesis, in osteoarthritis. METHODS: OA burden was quantified on the basis of radiographic features as total joint faces with an osteophyte, joint space narrowing, or in the spine, disc space narrowing...
2017: PloS One
https://www.readbyqxmd.com/read/29285839/role-of-ultrasound-guided-epidural-anesthesia-for-lower-limb-surgery-in-children-with-previously-repaired-meningomyelocele
#12
Vrushali C Ponde, Vinit V Bedekar, Dilip Chavan, Anuya Gursale, Dipal Shah
BACKGROUND: Children that have had a meningomyelocele repair often present for hip and bilateral lower limb surgeries. Due to vertebral, epidural, and nerve root abnormalities, placement of epidural catheter is difficult. AIMS: We aim to describe the potential role of ultrasound in delineating the most appropriate intervertebral space for central neuroaxial blocks in these patients. METHOD: Twelve children with previous meningomyelocele repair, in the age group of 6-12 years posted for hip or bilateral lower limb surgeries were included...
December 28, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29284565/bone-mineral-density-of-the-radius-predicts-all-cause-mortality-in-patients-with-type-2-diabetes-diabetes-heart-study
#13
Leon Lenchik, Thomas C Register, Fang-Chi Hsu, Jianzhao Xu, S Carrie Smith, J Jeffrey Carr, Barry I Freedman, Donald W Bowden
This study aimed to determine the association between areal and volumetric bone mineral density (BMD) with all-cause mortality in patients with type 2 diabetes (T2D). Associations between BMD and all-cause mortality were examined in 576 women and 517 men with T2D in the Diabetes Heart Study. Volumetric BMD in the thoracic and lumbar spine was measured with quantitative computed tomography. Areal BMD (aBMD) in the lumbar spine, total hip, femoral neck, ultradistal radius, mid radius, and whole body was measured using dual X-ray absorptiometry...
December 1, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29282554/soccer-helps-build-strong-bones-during-growth-a-systematic-review-and-meta-analysis
#14
REVIEW
Gabriel Lozano-Berges, Ángel Matute-Llorente, Alejandro González-Agüero, Alejandro Gómez-Bruton, Alba Gómez-Cabello, Germán Vicente-Rodríguez, José A Casajús
The aim of this study was to analyze the effects of soccer practice on bone in male and female children and adolescents. MEDLINE, PubMed, SPORTDiscus and Web of Science databases were searched for scientific articles published up to and including October 2016. Twenty-seven studies were included in this systematic review (13 in the meta-analysis). The meta-analysis was performed by using OpenMeta[Analyst] software. It is well documented that soccer practice during childhood provides positive effects on bone mineral content (BMC) and density (BMD) compared to sedentary behaviors and other sports, such as tennis, weightlifting, or swimming...
December 28, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29282548/the-qualyor-qualit%C3%A3-osseuse-lyon-orl%C3%A3-ans-study-a-new-cohort-for-non-invasive-evaluation-of-bone-quality-in-postmenopausal-osteoporosis-rationale-and-study-design
#15
Roland Chapurlat, Jean-Baptiste Pialat, Blandine Merle, Elisabeth Confavreux, Florence Duvert, Elisabeth Fontanges, Farida Khacef, Sylvie Loiseau Peres, Anne-Marie Schott, Eric Lespessailles
The diagnostic performance of densitometry is inadequate. New techniques of non-invasive evaluation of bone quality may improve fracture risk prediction. Testing the value of these techniques is the goal of the QUALYOR cohort. INTRODUCTION: The bone mineral density (BMD) of postmenopausal women who sustain osteoporotic fracture is generally above the World Health Organization definition for osteoporosis. Therefore, new approaches to improve the detection of women at high risk for fracture are warranted...
December 27, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29281126/effects-of-gastric-bypass-surgery-on-bone-mass-and-microarchitecture-occur-early-and-particularly-impact-postmenopausal-women
#16
Anne L Schafer, Galateia J Kazakia, Eric Vittinghoff, Lygia Stewart, Stanley J Rogers, Tiffany Y Kim, Jonathan T Carter, Andrew M Posselt, Courtney Pasco, Dolores M Shoback, Dennis M Black
Roux-en-Y gastric bypass (RYGB) surgery is a highly effective treatment for obesity but negatively affects the skeleton. Studies of skeletal effects have generally examined areal BMD by DXA, but DXA may be inaccurate in the setting of marked weight loss. Further, as a result of modestly sized samples of mostly premenopausal women and very few men, effects of RYGB by sex and menopausal status are unknown. We prospectively studied the effects of RYGB on skeletal health, including axial and appendicular volumetric BMD and appendicular bone microarchitecture and estimated strength...
December 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29280078/increased-risk-of-fractures-in-patients-with-polycystic-ovary-syndrome-a-nationwide-population-based-retrospective-cohort-study
#17
Hsin-Yi Yang, Herng-Sheng Lee, Wan-Ting Huang, Ming-Jer Chen, Solomon Chih-Cheng Chen, Yueh-Han Hsu
Polycystic ovary syndrome (PCOS) is a complex disorder; various features of this disorder may influence bone metabolism and skeletal mass. The contribution of PCOS to lower bone mineral density has been recognized. However, the impact of PCOS on the long-term risks for fractures remains inconclusive. The aim of this study was to determine the risk of overall fracture and fractures at different anatomic sites in patients with PCOS. Using a nationwide health insurance claims database, we included 11,106 subjects, aged 15-80 years, with newly diagnosed PCOS (ICD-9-CM: 254...
December 26, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29276732/normocalcemic-primary-hyperparathyroidism-associated-with-progressive-cortical-bone-loss-a-case-report
#18
Joseph R Tucci
The existence of normocalcemic primary hyperparathyroidism (NPHP) was acknowledged at the Third and Fourth International Proceedings on primary hyperparathyroidism PHPT but data relating to its clinical presentation, natural history, and skeletal status were limited and there was no information nor guidelines as to definitive therapy. Herein are reported biochemical, hormonal, and densitometry data in a postmenopausal woman seen initially for osteoporosis who was found to have increased serum PTH levels and normal serum total and ionized calcium levels without evidence of secondary hyperparathyroidism...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/29258886/the-risk-of-fragility-fractures-in-new-users-of-dipeptidyl-peptidase-4-inhibitors-compared-to-sulfonylureas-and-other-anti-diabetic-drugs-a-cohort-study
#19
John-Michael Gamble, Jennifer R Donnan, Eugene Chibrikov, Laurie K Twells, William K Midodzi, Sumit R Majumdar
AIMS: Mixed evidence exists for the effect of incretin-based therapies on osteoporosis in type-2 diabetes. Therefore, we conducted a cohort study to determine the association between dipeptidyl peptidase-4 (DPP-4) inhibitors and common osteoporotic "fragility fractures" (upper extremity, hip, spine). METHODS: The UK-based Clinical Practice Research Datalink was used to identify adults without prior fractures receiving a new anti-diabetic drug or a new type-2 diabetes diagnosis between 2007 and 2016...
December 16, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29251373/altered-erector-spinae-activity-and-trunk-motion-occurs-with-moderate-and-severe-unilateral-hip-oa
#20
Janice Moreside, Ivan Wong, Derek Rutherford
People with hip osteoarthritis (OA) demonstrate altered movement patterns in the hip joint, as well as the pelvis and spine. While kinematic changes have been described in the literature, little is known about the associated erector spinae (ES) activity. Increased or prolonged ES activity may contribute to the low back pain often associated with hip OA. Using a cross-sectional cohort study, 3D trunk motions and ES surface electromyography were recorded on 19 individuals with severe OA (SOA), 20 with moderate hip OA (MOA) and 19 asymptomatic (ASYM) individuals during treadmill walking, using standardized collection and processing procedures...
December 18, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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