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https://www.readbyqxmd.com/read/27910009/cancer-cytogenetics-an-introduction
#1
Thomas S K Wan
The Philadelphia chromosome was the first chromosomal abnormality discovered in cancer using the cytogenetics technique in 1960, and was consistently associated with chronic myeloid leukemia. Over the past five decades, innovative technical advances in the field of cancer cytogenetics have greatly enhanced the detection ability of chromosomal alterations, and have facilitated the research and diagnostic potential of chromosomal studies in neoplasms. These developments notwithstanding, chromosome analysis of a single cell is still the easiest way to delineate and understand the relationship between clonal evolution and disease progression of cancer cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27903834/saliva-diagnostics-current-views-and-directions
#2
Karolina Elżbieta Kaczor-Urbanowicz, Carmen Martin Carreras-Presas, Katri Aro, Michael Tu, Franklin Garcia-Godoy, David Tw Wong
In this review, we provide an update on the current and future applications of saliva for diagnostic purposes. There are many advantages of using saliva as a biofluid. Its collection is fast, easy, inexpensive, and non-invasive. In addition, saliva, as a "mirror of the body," can reflect the physiological and pathological state of the body. Therefore, it serves as a diagnostic and monitoring tool in many fields of science such as medicine, dentistry, and pharmacotherapy. Introduced in 2008, the term "Salivaomics" aimed to highlight the rapid development of knowledge about various "omics" constituents of saliva, including: proteome, transcriptome, micro-RNA, metabolome, and microbiome...
November 29, 2016: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27902520/rethinking-recovery-incorporating-holistic-nursing-perspectives-in-poststroke-care
#3
Frances Peterson-Burch, Karin Reuter-Rice, Taura L Barr
Stroke is a life-changing experience. Current treatments focus on treating the condition, rather than the whole person. The goal of this report was to communicate the benefits of a holistic approach to the treatment and recovery of stroke. Our intent was to begin a conversation to transform our approach to stroke care to focus on the whole person, body, mind, and spirit. Wellness approaches are fiscally responsible ways of providing holistic care for patients and their family members to help them achieve optimal individualized recovery...
January 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/27895529/assessing-nursing-staff-s-competences-in-mobility-support-in-nursing-home-care-development-and-psychometric-testing-of-the-kinaesthetics-competence-kc-observation-instrument
#4
Heidrun Gattinger, Helena Leino-Kilpi, Virpi Hantikainen, Sascha Köpke, Stefan Ott, Beate Senn
BACKGROUND: Between 75 and 89% of residents living in long-term care facilities have limited mobility. Nurses as well as other licensed and unlicensed personnel directly involved in resident care are in a key position to promote and maintain the mobility of care-dependent persons. This requires a certain level of competence. Kinaesthetics is a training concept used to increase nursing staff's interaction and movement support skills for assisting care-dependent persons in their daily activities...
2016: BMC Nursing
https://www.readbyqxmd.com/read/27884867/narrative-medicine-and-death-in-the-icu-word-clouds-as-a-visual-legacy
#5
Meredith Vanstone, Feli Toledo, France Clarke, Anne Boyle, Mita Giacomini, Marilyn Swinton, Lois Saunders, Melissa Shears, Nicole Zytaruk, Anne Woods, Trudy Rose, Tracey Hand-Breckenridge, Diane Heels-Ansdell, Shelley Anderson-White, Robert Sheppard, Deborah Cook
OBJECTIVE: The Word Cloud is a frequent wish in the 3 Wishes Project developed to nurture peace and ease the grieving process for dying critically ill patients. The objective was to examine whether Word Clouds can act as a heuristic approach to encourage a narrative orientation to medicine. Narrative medicine is an approach which can strengthen relationships, compassion and resilience. DESIGN: Word Clouds were created for 42 dying patients, and we interviewed 37 family members and 73 clinicians about their impact...
November 24, 2016: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/27882655/situated-technology-in-reproductive-health-care-do-we-need-a-new-theory-of-the-subject-to-promote-person-centred-care
#6
Biljana Stankovic
Going through reproductive experiences (especially pregnancy and childbirth) in contemporary Western societies almost inevitably involves interaction with medical practitioners and various medical technologies in institutional context. This has important consequences for women as embodied subjects. A critical appraisal of these consequences-coming dominantly from feminist scholarship-relied on a problematic theory of both technology and the subject, which are in contemporary approaches no longer considered as given, coherent and well individualized wholes, but as complex constellations that are locally situated and that can only be described empirically...
November 23, 2016: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/27864208/payer-view-of-personalized-medicine
#7
Edmund J Pezalla
PURPOSE: The process and methods used by payers when evaluating coverage of personalized medicine testing are described. SUMMARY: Personalized medicine encompasses a number of diagnostic tools that measure drug metabolism, genetic risk for disease development, and tumor type or markers that can guide oncology treatments. However, whole genome testing, tumor marker testing, and testing for drug metabolism are additional costs to the healthcare system. In order to justify these costs, payers and health technology assessment bodies must evaluate the individual tests or groups of tests on their own merits...
December 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27863579/evolution-of-a-nursing-model-for-identifying-client-needs-in-a-disaster-shelter-a-case-study-with-the-american-red-cross
#8
REVIEW
Janice Springer, Mary Casey-Lockyer
From the time of Clara Barton, Red Cross nursing has had a key role in the care and support of persons affected by disasters in the United States. Hurricane Katrina and other events brought to light the need for a shelter model that was inclusive of the whole community, including persons with disabilities, at-risk and vulnerable populations, and children. From an intake process to a nursing model for assessment, an evidence-guided process informed a systematic approach for a registered nurse-led model of care...
December 2016: Nursing Clinics of North America
https://www.readbyqxmd.com/read/27856017/-the-co-payment-of-the-dependence-from-the-structural-reform-of-2012-in-spain
#9
Raúl Del Pozo-Rubio, Isabel Pardo-García, Francisco Escribano-Sotos
OBJECTIVE: The objective of this piece of work is to establish the cost of dependency and the cost of financing it. Specifically, we will determine the cost of co-payment for individual users following the modification introduced by the 13th of July 2012 Resolution as well as its allocation by the autonomous regions. METHODS: The degree and level of dependency was established using the Survey on Disability, Personal Autonomy and Dependency Situations, 2008. The cost of dependency according to degree and level and autonomous regions was established with information from the System for Personal Autonomy and Care of Dependent Persons...
November 14, 2016: Gaceta Sanitaria
https://www.readbyqxmd.com/read/27837570/the-importance-of-the-patients-deemed-not-guilty-by-reason-of-insanity-for-the-psychiatric-reform
#10
EDITORIAL
Athanasios Douzenis
According to the Greek Penal Law if someone "because of a morbid disturbance of his mental functioning" (article 34) is acquitted of a crime or misdemeanour that the law punishes with more than 6 months imprisonment, then the court orders that this individual should be kept in a public psychiatric institution if the court reaches the conclusion that this person poses a threat to public safety.1 Individuals who have broken the law and deemed "not guilty by reason of insanity" are treated in psychiatric units of Psychiatric Hospitals according to the article 69 of the Penal Code...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27826531/next-generation-sequencing-techniques-in-liquid-biopsy-focus-on-non-small-cell-lung-cancer-patients
#11
REVIEW
Umberto Malapelle, Pasquale Pisapia, Danilo Rocco, Riccardo Smeraglio, Maria di Spirito, Claudio Bellevicine, Giancarlo Troncone
The advent of genomic based personalized medicine has led to multiple advances in the molecular characterization of many tumor types, such as non-small cell lung cancer (NSCLC). NSCLC is diagnosed in most cases on small tissue samples that may be not always sufficient for EGFR mutational assessment to select patients for first and second generations' tyrosine kinase inhibitors (TKIs) therapy. In patients without tissue availability at presentation, the analysis of cell free DNA (cfDNA) derived from liquid biopsy samples, in particular from plasma, represent an established alternative to provide EGFR mutational testing for treatment decision making...
October 2016: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/27810487/triclosan-exposure-results-in-alterations-of-thyroid-hormone-status-and-retarded-early-development-and-metamorphosis-in-cyprinodon-variegatus
#12
Joseph G Schnitzler, Bruno Frédérich, Mélanie Dussenne, Peter H M Klaren, Frédéric Silvestre, Krishna Das
Thyroid hormones are critically involved in somatic growth, development and metamorphosis of vertebrates. The structural similarity between thyroid hormones and triclosan, an antimicrobial compound widely employed in consumer personal care products, suggests triclosan can have adverse effects on the thyroid system. The sheepshead minnow, Cyprinodon variegatus, is now used in ecotoxicological studies that have recently begun to focus on potential disruption of the thyroid axis by endocrine disrupting compounds...
December 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27807747/text-mining-for-precision-medicine-bringing-structure-to-ehrs-and-biomedical-literature-to-understand-genes-and-health
#13
Michael Simmons, Ayush Singhal, Zhiyong Lu
The key question of precision medicine is whether it is possible to find clinically actionable granularity in diagnosing disease and classifying patient risk. The advent of next-generation sequencing and the widespread adoption of electronic health records (EHRs) have provided clinicians and researchers a wealth of data and made possible the precise characterization of individual patient genotypes and phenotypes. Unstructured text-found in biomedical publications and clinical notes-is an important component of genotype and phenotype knowledge...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27777477/study-of-scattered-radiation-during-fluoroscopy-in-hip-surgery
#14
Oksana Lesyuk, Patrick Emmanuel Sousa, Sónia Isabel do Espirito Santo Rodrigues, António Fernando Abrantes, Rui Pedro Pereira de Almeida, João Pedro Pinheiro, Kevin Barros Azevedo, Luís Pedro Vieira Ribeiro
OBJECTIVE: To measure the scattered radiation dose at different positions simulating hip surgery. MATERIALS AND METHODS: We simulated fluoroscopy-assisted hip surgery in order to study the distribution of scattered radiation in the operating room. To simulate the patient, we used a anthropomorphic whole-body phantom, and we used an X-ray-specific detector to quantify the radiation. Radiographs were obtained with a mobile C-arm X-ray system in continuous scan mode, with the tube at 0º (configuration 1) or 90º (configuration 2)...
July 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/27773596/early-antiretroviral-therapy-initiation-access-and-equity-of-viral-load-testing-for-hiv-treatment-monitoring
#15
Trevor Peter, Dennis Ellenberger, Andrea A Kim, Debrah Boeras, Tsehaynesh Messele, Teri Roberts, Wendy Stevens, Ilesh Jani, Alash'le Abimiku, Nathan Ford, Zachary Katz, John N Nkengasong
Scaling up access to HIV viral load testing for individuals undergoing antiretroviral therapy in low-resource settings is a global health priority, as emphasised by research showing the benefits of suppressed viral load for the individual and the whole population. Historically, large-scale diagnostic test implementation has been slow and incomplete because of service delivery and other challenges. Building on lessons from the past, in this Personal View we propose a new framework to accelerate viral load scale-up and ensure equitable access to this essential test...
October 20, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27766960/spontaneous-preterm-birth-and-single-nucleotide-gene-polymorphisms-a-recent-update
#16
Ishfaq A Sheikh, Ejaz Ahmad, Mohammad S Jamal, Mohd Rehan, Mourad Assidi, Iftikhar A Tayubi, Samera F AlBasri, Osama S Bajouh, Rola F Turki, Adel M Abuzenadah, Ghazi A Damanhouri, Mohd A Beg, Mohammed Al-Qahtani
BACKGROUND: Preterm birth (PTB), birth at <37 weeks of gestation, is a significant global public health problem. World-wide, about 15 million babies are born preterm each year resulting in more than a million deaths of children. Preterm neonates are more prone to problems and need intensive care hospitalization. Health issues may persist through early adulthood and even be carried on to the next generation. Majority (70 %) of PTBs are spontaneous with about a half without any apparent cause and the other half associated with a number of risk factors...
October 17, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27754759/a-qualitative-analysis-of-a-healthcare-professional-s-understanding-and-approach-to-management-of-spiritual-distress-in-an-acute-care-setting
#17
Debbie Selby, Dori Seccaraccia, Jim Huth, Kristin Kurrpa, Margaret Fitch
OBJECTIVE: The goal of this study was to explore healthcare professionals' (HCPs') perception of their role in provision of spiritual care, in addition to attempting to identify a simple question(s) to help identify spiritual distress. BACKGROUND: Spirituality is well recognized as important to whole-person care, particularly in those with terminal illnesses. Understanding the role of front-line providers in the identification and management of spiritual distress, however, remains challenging...
October 18, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27746902/health-as-a-complex-adaptive-system-a-new-dimension-of-patient-care-in-internal-medicine-and-general-practice
#18
Johannes Bircher, Eckhart G Hahn
This paper explores the diagnostic and therapeutic potential of a new concept of health. Investigations into the nature of health have led to a new definition that explains health as a complex adaptive system (CAS) and is based on five components (a-e). Humans like all biological creatures must satisfactorily respond to (a) the demands of life. For this purpose they need (b) a biologically given potential (BGP) and (c) a personally acquired potential (PAP). These properties of individuals are embedded within (d) social and (e) environmental determinants of health...
2016: F1000Research
https://www.readbyqxmd.com/read/27741489/the-impact-of-curricular-changes-on-bscn-students-clinical-learning-outcomes
#19
Janet Landeen, Donna Carr, Kirsten Culver, Lynn Martin, Nancy Matthew-Maich, Charlotte Noesgaard, Larissa Beney-Gadsby
Ongoing curricular renewal is a necessary phenomenon in nursing education to align learning with ever-changing professional practice demands. The McMaster Mohawk Conestoga BScN Program in Hamilton, Ontario, Canada recently engaged in a comprehensive curriculum renewal. The purpose of this study was to evaluate the impact of curricular changes on students' deep learning. Faculty perceptions about student learning outcomes during final year clinical placements were gathered through a combination of individual interviews and focus groups using Interpretive Descriptive qualitative research methodology...
November 2016: Nurse Education in Practice
https://www.readbyqxmd.com/read/27713033/a-10-year-longitudinal-study-of-effects-of-a-multifaceted-residency-spiritual-care-curriculum-clinical-ability-professional-formation-end-of-life-and-culture
#20
Gowri Anandarajah, Janet Roseman, Danny Lee, Nupur Dhandhania
CONTEXT: Although spiritual care (SC) is recognized as important in whole-person medicine, physicians infrequently address patients' spiritual needs, citing lack of training. Although many SC curricula descriptions exist, few studies report effects on physicians. OBJECTIVES: To broadly examine immediate and long-term effects of a required, longitudinal, residency SC curriculum, which emphasized inclusive patient-centered SC, compassion and spiritual self-care. METHODS: We conducted in-depth individual interviews with 26 physicians (13 intervention;13 comparison) trained at a 13-13-13 residency...
October 3, 2016: Journal of Pain and Symptom Management
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