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https://www.readbyqxmd.com/read/29140660/assessing-the-relative-influence-and-efficacy-of-public-and-private-food-safety-regulation-regimes-comparing-codex-and-global-g-a-p-standards
#1
Sam F Halabi, Ching-Fu Lin
An extensive global system of private food regulation is under construction, one that exceeds conventional regulation thought of as being driven by public authorities like FDA and USDA in the U.S. or the Food Standards Agency in the UK. Agrifood and grocer organizations, in concert with some farming groups, have been the primary designers of this new food regulatory regime. These groups have established alliances that compete with national regulators in complex ways. This article analyzes the relationship between public and private sources of food safety regulation by examining standards adopted by the Codex Alimentarius Commission, a food safety organization jointly run by the Food and Agricultural Organization and the World Health Organization and GlobalG...
2017: Food and Drug Law Journal
https://www.readbyqxmd.com/read/29140657/sunlight-and-other-disinfectants-disclosure-obligations-under-the-federal-securities-and-drug-regulatory-regimes
#2
Joseph G Milner
Drug development requires patience. Beyond the inherent uncertainty of the development process itself, U.S. drug developers must comply with the regulatory approval process overseen by the U.S. Food and Drug Administration (FDA). Because this process takes time, drug development also costs money. Drug companies seeking to raise funds in U.S. capital markets must navigate the securities regime governed by the Securities & Exchange Commission (SEC). Despite their similar roles as protectors of consumers and public markets, SEC and FDA send conflicting signals about the information drug companies need to disclose to the public...
2017: Food and Drug Law Journal
https://www.readbyqxmd.com/read/29139001/the-assessment-for-disinvestment-of-intramuscular-interferon-beta-for-relapsing-remitting-multiple-sclerosis-in-brazil
#3
REVIEW
Livia Lovato Pires de Lemos, Augusto Afonso Guerra Júnior, Marisa Santos, Carlos Magliano, Isabela Diniz, Kathiaja Souza, Ramon Gonçalves Pereira, Juliana Alvares, Brian Godman, Marion Bennie, Ivan Ricardo Zimmermann, Vânia Crisitna Canuto Dos Santos, Clarice Alegre Pretramale, Francisco de Assis Acurcio
In Brazil, inclusion and exclusion of health technologies within the Unified Health System (SUS) is the responsibility of the National Committee for Health Technology Incorporation (CONITEC). A recent Cochrane systematic review demonstrated that intramuscular interferon beta 1a (IFN-β-1a-IM) was inferior to the other beta interferons (IFN-βs) for multiple sclerosis (MS). As a result, CONITEC commissioned an analysis to review possible disinvestment within SUS. The objective of this paper is to describe the disinvestment process for IFN-β-1a-IM in Brazil...
November 14, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/29138197/incidence-of-shoulder-dislocations-in-the-uk-1995-2015-a-population-based-cohort-study
#4
Anjali Shah, Andrew Judge, Antonella Delmestri, Katherine Edwards, Nigel K Arden, Daniel Prieto-Alhambra, Tim A Holt, Rafael A Pinedo-Villanueva, Sally Hopewell, Sarah E Lamb, Amar Rangan, Andrew J Carr, Gary S Collins, Jonathan L Rees
OBJECTIVE: This cohort study evaluates the unknown age-specific and gender-specific incidence of primary shoulder dislocations in the UK. SETTING: UK primary care data from the Clinical Practice Research Datalink (CPRD) were used to identify patients aged 16-70 years with a shoulder dislocation during 1995-2015. Coding of primary shoulder dislocations was validated using the CPRD general practitioner questionnaire service. PARTICIPANTS: A cohort of 16 763 patients with shoulder dislocation aged 16-70 years during 1995-2015 were identified...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29137552/clinical-governance-breakdown-australian-cases-of-wilful-blindness-and-whistleblowing
#5
Sonja Cleary, Maxine Duke
BACKGROUND: After their attempts to have patient safety concerns addressed internally were ignored by wilfully blind managers, nurses from Bundaberg Base Hospital and Macarthur Health Service felt compelled to 'blow the whistle'. Wilful blindness is the human desire to prefer ignorance to knowledge; the responsibility to be informed is shirked. OBJECTIVE: To provide an account of instances of wilful blindness identified in two high-profile cases of nurse whistleblowing in Australia...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/29136796/a-multi-purpose-tool-for-food-inspection-simultaneous-determination-of-various-classes-of-preservatives-and-biogenic-amines-in-meat-and-fish-products-by-lc-ms
#6
Luciano Molognoni, Heitor Daguer, Leandro Antunes de Sá Ploêncio, Juliano De Dea Lindner
This paper describes an innovative fast and multipurpose method for the chemical inspection of meat and fish products by liquid chromatography-tandem mass spectrometry. Solid-liquid extraction and low temperature partitioning were applied to 17 analytes, which included large bacteriocins (3.5kDa) and small molecules (organic acids, heterocyclic compounds, polyene macrolides, alkyl esters of the p-hydroxybenzoic acid, aromatic, and aliphatic biogenic amines and polyamines). Chromatographic separation was achieved in 10min, using stationary phase of di-isopropyl-3-aminopropyl silane bound to hydroxylated silica...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136298/tuning-the-f%C3%A3-rster-resonance-energy-transfer-through-self-assembly-approach-for-efficient-white-light-emission-in-aqueous-medium
#7
Pragyan Pallavi, Bahadur Sk, Palak Ahir, Abhijit Patra
A simple and cost-effective methodology employing environmentally benign substances for the fabrication of white-light emitting materials is important for practical applications in the field of lighting and display devices. Designing of purely organic-based white-light emitting system with high quantum efficiency in the aqueous medium is an unmet challenge. With this objective, a new class of pyridoindole based hydrophobic fluorophore 6,7,8,9-tetrapropylpyrido[1,2-a]indole-10-carbaldehye (TPIC) was introduced...
November 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29135978/association-between-the-2012-health-and-social-care-act-and-specialist-visits-and-hospitalisations-in-england-a-controlled-interrupted-time-series-analysis
#8
James A Lopez Bernal, Christine Y Lu, Antonio Gasparrini, Steven Cummins, J Frank Wharham, Steven B Soumerai
BACKGROUND: The 2012 Health and Social Care Act (HSCA) in England led to among the largest healthcare reforms in the history of the National Health Service (NHS). It gave control of £67 billion of the NHS budget for secondary care to general practitioner (GP) led Clinical Commissioning Groups (CCGs). An expected outcome was that patient care would shift away from expensive hospital and specialist settings, towards less expensive community-based models. However, there is little evidence for the effectiveness of this approach...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29135818/trends-of-magnet-ingestion-in-children-an-ironic-attraction
#9
Patrick Todd Reeves, Cade M Nylund, Jayasree Krishnamurthy, R Adam Noel, Mazen I Abbas
BACKGROUND AND OBJECTIVES: Ingestion of rare earth magnets is a serious ongoing hazard for pediatric patients. Our study aims to investigate whether 2012 Consumer Product Safety Commission (CPSC) policy action, in coordination with efforts from consumer and physician advocacy groups, decreased the incidence of magnet ingestions in children in US since 2012. METHODS: Data from the National Electronic Injury Surveillance System (NEISS) was used to evaluate trends in emergency department (ED) encounters with pediatric patients (<18 years) who presented with suspected magnet ingestions (SMI) from 2010-2015...
November 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29132280/mixed-results-the-protective-role-of-schooling-in-the-hiv-epidemic-in-swaziland
#10
Alan Whiteside, Andriana Vinnitchok, Tengetile Dlamini, Khanya Mabuza
Swaziland has the highest HIV prevalence in the world. It is recognised that young women, especially adolescents, are particularly vulnerable to HIV infection and bear a disproportionate burden of HIV incidence. The HIV data from Swaziland show the location of the epidemic, which is particularly high among adolescent girls and young women. This paper is based on research in Swaziland, commissioned because of the perception that large numbers of children were dropping out of the school. It was assumed that these "dropouts" had increased risk of HIV exposure...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29131744/not-doomed-to-repeat-enhanced-mpfc-tracking-of-errors-promotes-adaptive-behavior-during-adolescence
#11
Ethan M McCormick, Eva H Telzer
Feedback information is one of the most powerful forces that promotes learning, providing guidance for changes to ongoing behavioral patterns. Previous examinations of feedback learning have largely relied on explicit feedback based on task performance. However, learning is not restricted to explicit feedback and likely involves other forms of more subtle feedback cues. One potential form of this kind of learning may involve internally generated feedback in response to error commission. Whether this error-related response prompts neural and behavioral adaptation that overlaps with, or is distinct from, those evoked by external feedback is largely unknown...
November 13, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29131305/quality-of-information-about-success-rates-provided-on-assisted-reproductive-technology-clinic-websites-in-australia-and-new-zealand
#12
Karin Hammarberg, Tess Prentice, Isabelle Purcell, Louise Johnson
BACKGROUND: Many factors influence the chance of having a baby with assisted reproductive technologies (ART). A 2016 Australian Competition and Consumer Commission (ACCC) investigation concluded that ART clinics needed to improve the quality of information they provide about chance of ART success. AIM: To evaluate changes in the quality of information about success rates provided on the websites of ART clinics in Australia and New Zealand before and after the ACCC investigation...
November 12, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29130901/quantification-of-fat-fraction-in-lumbar-vertebrae-correlation-with-age-and-implications-for-bone-marrow-dosimetry-in-molecular-radiotherapy
#13
Maikol Salas-Ramirez, Johannes Tran-Gia, Christian Kesenheimer, Andreas Max Weng, Aleksander Kosmala, Anke Heidemeier, Herbert Koestler, Michael Lassmann
Absorbed dose to active bone marrow is a predictor of hematological toxicity in molecular radiotherapy. Due to the complex composition of bone marrow tissue, the necessity to improve the personalized dosimetry has led to the application of non-conventional imaging methods in nuclear medicine. The aim of this study is to apply magnetic resonance imaging (MRI) for quantification of the fat fraction in lumbar vertebrae and to analyze its implications for bone marrow dosimetry. Methods First, a highly accelerated two-point Dixon MRI sequence for fat-water separation was validated in a 3T system against the magnetic resonance spectroscopy (MRS) gold standard...
November 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29130870/modern-technology-to-support-carers-of-care-recipients-with-dementia-or-functional-mental-illness-promising-progress-but-a-long-road-ahead
#14
Nicola T Lautenschlager, Janine Diehl-Schmid, Samantha M Loi, Johannes Mayer, Maria Tensil, Alexander F Kurz
There is no doubt that family carers who look after a family member with dementia or with a functional mental illness fulfill an important role, not only for their loved one, but also for the health and aged care systems of the countries they live in. Due to increasing life expectancy, but also improved healthcare the number of family carers supporting older care recipients with functional mental illness or dementia is on the rise. While the carer role often can offer rewarding experiences caregivers are at increased risk of stress, depression, sleep problems, and often experience poor health outcomes with increased morbidity and mortality (Oyebode, 2003)...
December 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29130840/what-works-for-wellbeing-a-systematic-review-of-wellbeing-outcomes-for-music-and-singing-in-adults
#15
Norma Daykin, Louise Mansfield, Catherine Meads, Guy Julier, Alan Tomlinson, Annette Payne, Lily Grigsby Duffy, Jack Lane, Giorgia D'Innocenzo, Adele Burnett, Tess Kay, Paul Dolan, Stefano Testoni, Christina Victor
AIMS: The role of arts and music in supporting subjective wellbeing (SWB) is increasingly recognised. Robust evidence is needed to support policy and practice. This article reports on the first of four reviews of Culture, Sport and Wellbeing (CSW) commissioned by the Economic and Social Research Council (ESRC)-funded What Works Centre for Wellbeing ( https://whatworkswellbeing.org/ ). OBJECTIVE: To identify SWB outcomes for music and singing in adults. METHODS: Comprehensive literature searches were conducted in PsychInfo, Medline, ERIC, Arts and Humanities, Social Science and Science Citation Indexes, Scopus, PILOTS and CINAHL databases...
November 1, 2017: Perspectives in Public Health
https://www.readbyqxmd.com/read/29130224/-interpretation-of-2017-national-comprehensive-cancer-network-nccn-guidelines-for-the-diagnosis-and-treatment-of-esophageal-squamous-cell-carcinoma-through-the-new-tnm-staging-of-esophageal-carcinoma-eighth-edition-by-the-union-for-international-cancer-control
#16
Wentao Fang
The eighth edition of Union for International Cancer Control (UICC) and the American Joint Committee on Cancer(AJCC) announced in 2017 the new staging of esophageal cancer, focusing on the prognostic significance of accurate staging and lymph node metastasis before treatment of esophageal carcinoma, the rationality of early tumor therapy, and the importance of induction therapy. The modified 2017 edition of the National Comprehensive Cancer Network (NCCN) guidelines, based on above contents matching UICC/AJCC eighth edition of the new staging of esophageal cancer, added preoperative clinical staging to guide the selection of treatment, and re-defined the indications of endoscopic resection and operation for early esophageal squamous cell carcinoma, meanwhile emphasized once again the importance of preoperative induction therapy for locally advanced esophageal squamous cell carcinoma...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29130130/heavy-metal-distribution-in-tiaoxi-river-s-sediment
#17
Binghui Zheng, Shaoyong Lu, Jinan Wu, Xiaochun Guo, Fengchang Wu, Xiangling Li, Qi He, Zhiyou Fu, Libin Xu
According to current study, seven surface sediments and three sediment cores were collected from three typical areas of Tiaoxi River, which were living area, agricultural area, and industrial area. The water quantity into the Lake Taihu from the Tiaoxi River accounted for almost one third of the total water quantity by all rivers into the Lake Taihu. To study geochemical features and pollution history of heavy metals in three typical areas of Tiaoxi River, total content and chemical fractionations of Cu, Pb, Cd, Cr, Mn, Zn, Fe, As, and Hg were analyzed for surface and core sediments using the speciation extraction procedure, proposed by the Commission of the European Communities Bureau of Reference (BCR), together with grain size and organic carbon measurements...
November 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29129020/ethical-aspects-of-medical-age-assessment-in-the-asylum-process-a-swedish-perspective
#18
Erik Malmqvist, Elisabeth Furberg, Lars Sandman
According to European regulations and the legislations of individual member states, children who seek asylum have a different set of rights than adults in a similar position. To protect these rights and ensure rule of law, migration authorities are commonly required to assess the age of asylum seekers who lack reliable documentation, including through various medical methods. However, many healthcare professionals and other commentators consider medical age assessment to be ethically problematic. This paper presents a simplified and amended account of the main findings of a recent ethical analysis of medical age assessment in the asylum process commissioned by the Swedish National Board of Health and Welfare...
November 11, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29127719/critical-evaluation-of-the-american-joint-commission-on-cancer-ajcc-8th-edition-staging-system-for-patients-with-hepatocellular-carcinoma-hcc-a-surveillance-epidemiology-end-results-seer-analysis
#19
Sivesh K Kamarajah, Timothy L Frankel, Christopher Sonnenday, Clifford S Cho, Hari Nathan
BACKGROUND: Recently, the American Joint Committee on Cancer (AJCC) released its 8th edition changes to the staging system for hepatocellular cancer (HCC). We sought to validate the 8th edition staging system and compare the performance to the 7th edition using a population-based data set. METHODS: Using the Surveillance, Epidemiology and End Results (SEER) database (1998-2013), patients undergoing resection or transplant for non-metastatic HCC were identified. Overall survival was estimated using the Kaplan-Meier method and compared using log-rank tests...
November 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29126274/rightcare-wrong-answers
#20
Greg Dropkin
Background: NHS RightCare is an NHS England programme describing itself as 'a proven approach that delivers better patient outcomes'. It identifies opportunities for savings and quality improvements, comparing each Clinical Commissioning Group (CCG) with the 'Best 5' of a fixed set of 'Similar 10' CCGs chosen using equally weighted demographic and deprivation indicators. This article tests whether these indicators are sufficient and equal weighting is appropriate, and evaluates significance...
November 3, 2017: Journal of Public Health
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