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https://www.readbyqxmd.com/read/29036870/development-and-validation-of-a-new-safety-climate-scale-for-petrochemical-industries
#1
Mohammad Javad Jafari, Davood Eskandari, Firouz Valipour, Yadollah Mehrabi, Hossein Charkhand, Mostafa Mirghotbi
BACKGROUND: While a considerable body of research has studied safety climate and its role as a leading indicator of organizational safety, much of this work has been conducted with Western manufacturing samples. OBJECTIVE: The current study puts emphasis on the cross-validation of a safety climate model in the non-Western industrial context of Iranian petrochemical industries. METHODS: The current study was performed in one petrochemical company in Iran...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036604/accomplishing-reform-successful-case-studies-drawn-from-the-health-systems-of-60-countries
#2
Jeffrey Braithwaite, Russell Mannion, Yukihiro Matsuyama, Paul Shekelle, Stuart Whittaker, Samir Al-Adawi, Kristiana Ludlow, Wendy James, Hsuen P Ting, Jessica Herkes, Louise A Ellis, Kate Churruca, Wendy Nicklin, Clifford Hughes
Healthcare reform typically involves orchestrating a policy change, mediated through some form of operational, systems, financial, process or practice intervention. The aim is to improve the ways in which care is delivered to patients. In our book 'Health Systems Improvement Across the Globe: Success Stories from 60 Countries', we gathered case-study accomplishments from 60 countries. A unique feature of the collection is the diversity of included countries, from the wealthiest and most politically stable such as Japan, Qatar and Canada, to some of the poorest, most densely populated or politically challenged, including Afghanistan, Guinea and Nigeria...
September 20, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29036543/pilot-reported-beta-blockers-identified-by-forensic-toxicology-analysis-of-postmortem-specimens
#3
Dennis V Canfield, Kurt M Dubowski, James M Whinnery, Estrella M Forster
Introduction: This study compared beta-blockers reported by pilots with the medications found by postmortem toxicology analysis of specimens received from fatal aviation accidents between 1999 and 2015. Several studies have compared drugs using the standard approach: Compare the drug found by toxicology analysis with the drug reported by the pilot. This study uniquely examined first the pilot-reported medication and then compared it to that detected by toxicology analysis. This study will serve two purposes: (i) to determine the capability of a toxicology laboratory to detect reported medications, and (ii) to identify pilots with medications below detectable limits...
September 25, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29035911/ab-interno-gel-implant-for-the-treatment-of-glaucoma-patients-with-or-without-prior-glaucoma-surgery-one-year-results
#4
Fritz H Hengerer, Thomas Kohnen, Michael Mueller, Ina Conrad-Hengerer
PURPOSE: To evaluate IOP lowering effects and complication management of an ab interno gel implant for the treatment of patients refractory to anti-glaucoma medication or glaucoma surgery. METHODS: Retrospective analysis of the medical records of 242 consecutive eyes of 146 patients with uncontrolled intraocular pressure (IOP) despite maximum tolerated medical therapy or prior surgical intervention that underwent XEN45 implantation (as sole procedure or in combination with cataract surgery) between March 2014 and June 2015...
October 13, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/29035813/energy-loss-and-impact-of-various-stunning-devices-used-for-the-slaughtering-of-water-buffaloes
#5
Matthieu Glardon, Barbara K Schwenk, Fabiano Riva, Adrian von Holzen, Steffen G Ross, Beat P Kneubuehl, Michael H Stoffel
Stock management of the Swiss water buffalo livestock results in the slaughtering of about 350 animals per year. As the stunning of water buffaloes still is an unresolved issue, we investigated the terminal ballistics of currently used perforating stunning devices. Cartridge fired captive bolt devices, handguns and a bullet casing gun were tested in a shooting steep by firing on bisected heads, forehead plates and soap blocks. Energy loss of captive bolts confirmed their inadequacy when used for heavy water buffaloes, notably adult males...
September 28, 2017: Meat Science
https://www.readbyqxmd.com/read/29034533/efficacy-tolerability-and-safety-of-cannabis-based-medicines-for-chronic-pain-management-an-overview-of-systematic-reviews
#6
REVIEW
W Häuser, F Petzke, M-A Fitzcharles
Medicinal cannabis has already entered mainstream medicine in some countries. This systematic review (SR) aimed at evaluating the efficacy, acceptability and safety of cannabis-based medicines for chronic pain management. Qualitative systematic review of SRs of randomized controlled trials with cannabis-based medicines for chronic pain management. The Cochrane databases of SRs, Database of Abstracts of Reviews of Effects and PubMed were searched for SR published in the period January 2009 to January 2017. Assessment of the methodological quality of SR was performed by the AMSTAR checklist...
October 15, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29033620/comparative-safety-of-intravenous-ferumoxytol-versus-ferric-carboxymaltose-for-the-treatment-of-iron-deficiency-anemia-rationale-and-study-design-of-a-randomized-double-blind-study-with-a-focus-on-acute-hypersensitivity-reactions
#7
N Franklin Adkinson, William E Strauss, Kristine Bernard, Robert F Kaper, Iain C Macdougall, Julie S Krop
BACKGROUND: Intravenous (IV) iron is often used to treat iron deficiency anemia in patients who are unable to tolerate or are inadequately managed with oral iron. However, IV iron treatment has been associated with acute hypersensitivity reactions. The comparative risk of adverse events (AEs) with IV iron preparations has been assessed by a few randomized controlled trials, which are most often limited by small patient numbers, which lack statistical power to identify differences in low-frequency AE such as hypersensitivity reactions...
2017: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29033575/renal-safety-of-tenofovir-and-or-entecavir-in-patients-with-chronic-hbv-monoinfection
#8
REVIEW
Young-Mo Yang, Eun Joo Choi
BACKGROUND: Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line therapy for chronic hepatitis B (CHB) due to their genetic barrier to resistance and effectiveness of virological suppression. TDF and ETV may cause renal toxicity through various mechanisms such as renal tubular injury, apoptosis, and mitochondrial toxicity. The aims of the current review were to assess the potential renal toxicity associated with the use of TDF and ETV in patients infected with chronic hepatitis B virus (HBV) and to provide clinical perspectives on these two agents in the treatment of CHB...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29033468/the-aviation-paradox-why-we-can-know-jetliners-but-not-reactors
#9
John Downer
Publics and policymakers increasingly have to contend with the risks of complex, safety-critical technologies, such as airframes and reactors. As such, 'technological risk' has become an important object of modern governance, with state regulators as core agents, and 'reliability assessment' as the most essential metric. The Science and Technology Studies (STS) literature casts doubt on whether or not we should place our faith in these assessments because predictively calculating the ultra-high reliability required of such systems poses seemingly insurmountable epistemological problems...
2017: Minerva
https://www.readbyqxmd.com/read/29033209/a-worldwide-comparison-of-the-management-of-t1-and-t2-anterior-floor-of-the-mouth-and-tongue-squamous-cell-carcinoma-extent-of-surgical-resection-and-reconstructive-measures
#10
Katinka Kansy, Andreas Albert Mueller, Thomas Mücke, Friederike Koersgen, Klaus Dietrich Wolff, Hans-Florian Zeilhofer, Frank Hölzle, Winnie Pradel, Matthias Schneider, Andreas Kolk, Ralf Smeets, Julio Acero, Piet Haers, G E Ghali, Jürgen Hoffmann
INTRODUCTION: Microvascular surgery following tumor resection has become an important field of oral maxillofacial surgery (OMFS). Following the results on general aspects of current reconstructive practice in German-speaking countries, Europe and worldwide, this paper presents specific concepts for the management of resection and reconstruction of T1/T2 squamous cell carcinoma (SCC) of the anterior floor of the mouth and tongue. METHODS: The DOESAK questionnaire was distributed in three different phases to a growing number of maxillofacial units worldwide...
September 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29032756/antidiabetic-drugs-as-antihypertensives-new-data-on-the-horizon
#11
Vassiliki Mamakou, Ioanna Eleftheriadou, Niki Katsiki, Konstantinos Makrilakis, Konstantinos Tsioufis, Nikoalos Tentolouris
The prevalence of type 2 diabetes mellitus (T2DM) increases worldwide, forcing for more research in the area of the optimal diabetes management. Cardiovascular disease (CVD) remains the commonest cause of death in individuals with T2DM. Besides hyperglycemia, an explanation for the increased mortality in this population is the increased prevalence of comorbidities, such as hypertension and dyslipidemia. Recent population-based studies described a prevalence of hypertension greater than 80% in patients with T2DM...
October 10, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29032452/treatment-outcomes-with-biosimilars-be-aware-of-the-nocebo-effect
#12
REVIEW
Mourad F Rezk, Burkhard Pieper
Over the years, biologic agents have proven their importance in the management of chronic autoimmune diseases, such as rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Biosimilars, which are biologic medicines, are highly similar to approved biologic medicines, and are comprehensively developed and rigorously tested to ensure efficacy and safety are similar to the reference product. A broader armamentarium of biosimilars is expected to improve patients' access to safe and effective biologic medicines, thus offering benefits to healthcare systems around the globe...
October 14, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29032264/building-a-safer-and-faster-car-seatbelts-airbags-and-crispr
#13
REVIEW
Miguel-Angel Perales, Partow Kebriaei, Leslie S Kean, Michel Sadelain
Therapeutic T cell engineering has recently garnered widespread interest owing to the success of CD19 (Chimeric Antigen Receptor) CAR therapy. CARs are synthetic receptors for antigen that redirect the specificity and reprogram the function of the T cells in which they are genetically introduced. CARs targeting CD19, a cell surface molecule found in most leukemias and lymphomas, have yielded high remission rates in patients with chemorefractory, relapsed disease, including acute lymphoblastic leukemia, chronic lymphocytic leukemia and non-Hodgkin lymphoma...
October 12, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29031841/management-of-post-radical-prostatectomy-urinary-incontinence-a-review
#14
REVIEW
Kushan D Radadia, Nicholas J Farber, Brian Shinder, Charles F Polotti, Lee J Milas, Hari Tunuguntla
Post-prostatectomy urinary incontinence (PPUI) has significant impact on the quality of life of patients who undergo radical prostatectomy. Stress and overflow incontinence may result from the procedure, with sphincteric incompetence and detrusor hypocontractility implicating their development, respectively. In many cases, treatment begins with conservative approaches, including pelvic floor muscle training/biofeedback. Pharmacotherapy can be used to treat overactive bladder. For stress incontinence, transurethral bulking agents are utilized in select patients, however AUS and male slings are the most efficacious options with good success rates...
October 11, 2017: Urology
https://www.readbyqxmd.com/read/29031661/guidelines-and-algorithms-for-managing-the-difficult-airway
#15
M A Gómez-Ríos, L Gaitini, I Matter, M Somri
The difficult airway constitutes a continuous challenge for anesthesiologists. Guidelines and algorithms are key to preserving patient safety, by recommending specific plans and strategies that address predicted or unexpected difficult airway. However, there are currently no "gold standard" algorithms or universally accepted standards. The aim of this article is to present a synthesis of the recommendations of the main guidelines and difficult airway algorithms.
October 11, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29030968/mycoflora-assessment-growth-and-toxigenic-features-of-patulin-producers-in-kiwifruit-in-china
#16
Yuan Wang, Kewei Feng, Bin Liu, Zhiwei Zhang, Jianping Wei, Yahong Yuan, Tianli Yue
BACKGROUND: Fungal development in agricultural products may cause mycotoxin contamination that are a significant threat to food safety. Patulin (PAT) and PAT-producers contamination has been established as a worldwide problem. The present study was conducted to investigate the mycoflora and PAT-producers present in kiwifruits and environmental samples collected from orchards and processing plants in Shaanxi Province, China. RESULTS: Variations in mycoflora were observed in different samples, with penicillia and aspergilli as the predominant genera...
October 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29030677/safe-surgery-for-all-early-lessons-from-implementing-a-national-government-driven-surgical-plan-in-ethiopia
#17
Daniel Burssa, Atlibachew Teshome, Katherine Iverson, Olivia Ahearn, Tigistu Ashengo, David Barash, Erin Barringer, Isabelle Citron, Kaya Garringer, Victoria McKitrick, John Meara, Abraham Mengistu, Swagoto Mukhopadhyay, Cheri Reynolds, Mark Shrime, Asha Varghese, Samson Esseye, Abebe Bekele
Recognizing the unmet need for surgical care in Ethiopia, the Federal Ministry of Health (FMOH) has pioneered innovative methodologies for surgical system development with Saving Lives through Safe Surgery (SaLTS). SaLTS is a national flagship initiative designed to improve access to safe, essential and emergency surgical and anaesthesia care across all levels of the healthcare system. Sustained commitment from the FMOH and their recruitment of implementing partners has led to notable accomplishments across the breadth of the surgical system, including but not limited to: (1) Leadership, management and governance-a nationally scaled surgical leadership and mentorship programme, (2) Infrastructure-operating room construction and oxygen delivery plan, (3) Supplies and logistics-a national essential surgical procedure and equipment list, (4) Human resource development-a Surgical Workforce Expansion Plan and Anaesthesia National Roadmap, (5) Advocacy and partnership-strong FMOH partnership with international organizations, including GE Foundation's SafeSurgery2020 initiative, (6) Innovation-facility-driven identification of problems and solutions, (7) Quality of surgical and anaesthesia care service delivery-a national peri-operative guideline and WHO Surgical Safety Checklist implementation, and (8) Monitoring and evaluation-a comprehensive plan for short-term and long-term assessment of surgical quality and capacity...
October 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29030642/saline-is-as-effective-as-nitrogen-scavengers-for-treatment-of-hyperammonemia
#18
G van Straten, M G M de Sain-van der Velden, I M van Geijlswijk, R P Favier, S J Mesu, N E Holwerda-Loof, M van der Ham, H Fieten, J Rothuizen, B Spee, N M Verhoeven-Duif
Urea cycle enzyme deficiency (UCED) patients with hyperammonemia are treated with sodium benzoate (SB) and sodium phenylacetate (SPA) to induce alternative pathways of nitrogen excretion. The suggested guidelines supporting their use in the management of hyperammonemia are primarily based on non-analytic studies such as case reports and case series. Canine congenital portosystemic shunting (CPSS) is a naturally occurring model for hyperammonemia. Here, we performed cross-over, randomized, placebo-controlled studies in healthy dogs to assess safety and pharmacokinetics of SB and SPA (phase I)...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29030119/weee-plastic-sorting-for-bromine-essential-to-enforce-eu-regulation
#19
Pierre Hennebert, Montserrat Filella
The plastics of waste of electric and electronic equipment (WEEE) are improved for fire safety by flame retardants, and particularly brominated flame retardants (BFR). As waste, the management of these plastic fractions must comply with the update of the regulation of waste hazard classification (2014, 2017), the publication of a technical standard on management of WEEE (2015), and a restriction of use for decabromodiphenylether in the product regulation (2017). Data of bromine (n=4283) and BFR concentrations (n=98) in plastics from electric and electronic equipment (EEE), and from WEEE processing facilities before and after sorting for bromine in four sites in France have been studied for chemical composition and for regulatory classification...
October 10, 2017: Waste Management
https://www.readbyqxmd.com/read/29029712/advanced-cardiopulmonary-support-for-pulmonary-embolism
#20
Oren Friedman, James M Horowitz, Danny Ramzy
Management of high-risk pulmonary embolism (PE) requires an understanding of the pathophysiology of PE, options for rapid clot reduction, critical care interventions, and advanced cardiopulmonary support. PE can lead to rapid respiratory and hemodynamic collapse via a complex sequence of events leading to acute right ventricular failure. Importantly, reduction in pulmonary vascular resistance must be accomplished either by systemic thrombolytics, catheter directed thrombolytics, endovascular clot extraction, or surgical embolectomy...
September 2017: Techniques in Vascular and Interventional Radiology
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