keyword
https://read.qxmd.com/read/38500556/severe-copd-multidisciplinary-consultation-to-get-the-right-care-at-the-right-place
#21
JOURNAL ARTICLE
Pieter-Paul Hekking, Monique van Meggelen, W Johan Lie, Rogier Arnaud Sebastiaan Hoek, Dirk van Ranst, Stephan Cornelis Johan van der Kleij, Leonard Seghers, Jasper Kappen, Gert-Jan Braunstahl, Johannes In 't Veen
No abstract text is available yet for this article.
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38499871/mammal-responses-to-global-changes-in-human-activity-vary-by-trophic-group-and-landscape
#22
JOURNAL ARTICLE
A Cole Burton, Christopher Beirne, Kaitlyn M Gaynor, Catherine Sun, Alys Granados, Maximilian L Allen, Jesse M Alston, Guilherme C Alvarenga, Francisco Samuel Álvarez Calderón, Zachary Amir, Christine Anhalt-Depies, Cara Appel, Stephanny Arroyo-Arce, Guy Balme, Avi Bar-Massada, Daniele Barcelos, Evan Barr, Erika L Barthelmess, Carolina Baruzzi, Sayantani M Basak, Natalie Beenaerts, Jonathan Belmaker, Olgirda Belova, Branko Bezarević, Tori Bird, Daniel A Bogan, Neda Bogdanović, Andy Boyce, Mark Boyce, LaRoy Brandt, Jedediah F Brodie, Jarred Brooke, Jakub W Bubnicki, Francesca Cagnacci, Benjamin Scott Carr, João Carvalho, Jim Casaer, Rok Černe, Ron Chen, Emily Chow, Marcin Churski, Connor Cincotta, Duško Ćirović, T D Coates, Justin Compton, Courtney Coon, Michael V Cove, Anthony P Crupi, Simone Dal Farra, Andrea K Darracq, Miranda Davis, Kimberly Dawe, Valerie De Waele, Esther Descalzo, Tom A Diserens, Jakub Drimaj, Martin Duľa, Susan Ellis-Felege, Caroline Ellison, Alper Ertürk, Jean Fantle-Lepczyk, Jorie Favreau, Mitch Fennell, Pablo Ferreras, Francesco Ferretti, Christian Fiderer, Laura Finnegan, Jason T Fisher, M Caitlin Fisher-Reid, Elizabeth A Flaherty, Urša Fležar, Jiří Flousek, Jennifer M Foca, Adam Ford, Barbara Franzetti, Sandra Frey, Sarah Fritts, Šárka Frýbová, Brett Furnas, Brian Gerber, Hayley M Geyle, Diego G Giménez, Anthony J Giordano, Tomislav Gomercic, Matthew E Gompper, Diogo Maia Gräbin, Morgan Gray, Austin Green, Robert Hagen, Robert Bob Hagen, Steven Hammerich, Catharine Hanekom, Christopher Hansen, Steven Hasstedt, Mark Hebblewhite, Marco Heurich, Tim R Hofmeester, Tru Hubbard, David Jachowski, Patrick A Jansen, Kodi Jo Jaspers, Alex Jensen, Mark Jordan, Mariane C Kaizer, Marcella J Kelly, Michel T Kohl, Stephanie Kramer-Schadt, Miha Krofel, Andrea Krug, Kellie M Kuhn, Dries P J Kuijper, Erin K Kuprewicz, Josip Kusak, Miroslav Kutal, Diana J R Lafferty, Summer LaRose, Marcus Lashley, Richard Lathrop, Thomas E Lee, Christopher Lepczyk, Damon B Lesmeister, Alain Licoppe, Marco Linnell, Jan Loch, Robert Long, Robert C Lonsinger, Julie Louvrier, Matthew Scott Luskin, Paula MacKay, Sean Maher, Benoît Manet, Gareth K H Mann, Andrew J Marshall, David Mason, Zara McDonald, Tracy McKay, William J McShea, Matt Mechler, Claude Miaud, Joshua J Millspaugh, Claudio M Monteza-Moreno, Dario Moreira-Arce, Kayleigh Mullen, Christopher Nagy, Robin Naidoo, Itai Namir, Carrie Nelson, Brian O'Neill, M Teague O'Mara, Valentina Oberosler, Christian Osorio, Federico Ossi, Pablo Palencia, Kimberly Pearson, Luca Pedrotti, Charles E Pekins, Mary Pendergast, Fernando F Pinho, Radim Plhal, Xochilt Pocasangre-Orellana, Melissa Price, Michael Procko, Mike D Proctor, Emiliano Esterci Ramalho, Nathan Ranc, Slaven Reljic, Katie Remine, Michael Rentz, Ronald Revord, Rafael Reyna-Hurtado, Derek Risch, Euan G Ritchie, Andrea Romero, Christopher Rota, Francesco Rovero, Helen Rowe, Christian Rutz, Marco Salvatori, Derek Sandow, Christopher M Schalk, Jenna Scherger, Jan Schipper, Daniel G Scognamillo, Çağan H Şekercioğlu, Paola Semenzato, Jennifer Sevin, Hila Shamon, Catherine Shier, Eduardo A Silva-Rodríguez, Magda Sindicic, Lucy K Smyth, Anil Soyumert, Tiffany Sprague, Colleen Cassady St Clair, Jennifer Stenglein, Philip A Stephens, Kinga Magdalena Stępniak, Michael Stevens, Cassondra Stevenson, Bálint Ternyik, Ian Thomson, Rita T Torres, Joan Tremblay, Tomas Urrutia, Jean-Pierre Vacher, Darcy Visscher, Stephen L Webb, Julian Weber, Katherine C B Weiss, Laura S Whipple, Christopher A Whittier, Jesse Whittington, Izabela Wierzbowska, Martin Wikelski, Jacque Williamson, Christopher C Wilmers, Todd Windle, Heiko U Wittmer, Yuri Zharikov, Adam Zorn, Roland Kays
Wildlife must adapt to human presence to survive in the Anthropocene, so it is critical to understand species responses to humans in different contexts. We used camera trapping as a lens to view mammal responses to changes in human activity during the COVID-19 pandemic. Across 163 species sampled in 102 projects around the world, changes in the amount and timing of animal activity varied widely. Under higher human activity, mammals were less active in undeveloped areas but unexpectedly more active in developed areas while exhibiting greater nocturnality...
March 18, 2024: Nature Ecology & Evolution
https://read.qxmd.com/read/38499808/sorla-restricts-tnf%C3%AE-release-from-microglia-to-shape-a-glioma-supportive-brain-microenvironment
#23
JOURNAL ARTICLE
Paulina Kaminska, Peter L Ovesen, Mateusz Jakiel, Tomasz Obrebski, Vanessa Schmidt, Michal Draminski, Aleksandra G Bilska, Magdalena Bieniek, Jasper Anink, Bohdan Paterczyk, Anne Mette Gissel Jensen, Sylwia Piatek, Olav M Andersen, Eleonora Aronica, Thomas E Willnow, Bozena Kaminska, Michal J Dabrowski, Anna R Malik
SorLA, encoded by the gene SORL1, is an intracellular sorting receptor of the VPS10P domain receptor gene family. Although SorLA is best recognized for its ability to shuttle target proteins between intracellular compartments in neurons, recent data suggest that also its microglial expression can be of high relevance for the pathogenesis of brain diseases, including glioblastoma (GBM). Here, we interrogated the impact of SorLA on the functional properties of glioma-associated microglia and macrophages (GAMs)...
March 18, 2024: EMBO Reports
https://read.qxmd.com/read/38499516/protocol-of-the-latfia-trial-laser-assisted-treatment-of-fistula-in-ano-a-multicentre-prospective-randomized-controlled-trial-comparing-fistula-tract-laser-closure-filac%C3%A2-with-rectal-advancement-flap-for-high-trans-sphincteric-fistulas
#24
JOURNAL ARTICLE
Marie Gaillard, Sylvie Van den Broeck, Bart Op de Beeck, Kristien Wouters, Jasper Stijns, Dirk Van de Putte, Ben Gys, Bert Houben, Els Van Dessel, Gabriele Bislenghi, Niels Komen
AIM: Anal fistula is one of the most common anal diseases, affecting between 1 and 3 per 10 000 people per year. Symptoms have a potentially severe effect on a patient's quality of life. Surgery is the mainstay of treatment, aiming to cure the fistula and preserve anal sphincter function. Rectal advancement flap (RAF) is currently the gold standard treatment but has recurrence rates varying between 20% and 50% and might lead to disturbance of continence. The aim of the trial described in this work is to discover if the minimally invasive fistula tract laser closure (FiLaC™) technique could achieve higher healing rates and a better functional outcome than RAF...
March 18, 2024: Colorectal Disease
https://read.qxmd.com/read/38497831/dilute-gel-networks-vs-clumpy-gels-in-colloidal-systems-with-a-competition-between-repulsive-and-attractive-interactions
#25
JOURNAL ARTICLE
M Gimperlein, Jasper N Immink, M Schmiedeberg
Using Brownian dynamics simulations we study gel-forming colloidal systems. The focus of this article lies on the differences of dense and dilute gel networks in terms of structure formation both on a local and a global level. We apply reduction algorithms and observe that dilute networks and dense gels differ in the way structural properties like the thickness of strands emerge. We also analyze the percolation behavior and find that two different regimes of percolation exist which might be responsible for structural differences...
March 18, 2024: Soft Matter
https://read.qxmd.com/read/38496735/right-bundle-branch-activation-during-left-bundle-branch-pacing-marginal-gains-in-left-bundle-branch-pacing-optimized-cardiac-resynchronization-therapy-and-the-effects-of-atrioventricular-delay-dynamic-optimization
#26
Julian Cheong Kiat Tay, Eric Tien Siang Lim, Terence Jiahui Wong, Jasper Jingyao Feng, Chi Keong Ching, Boon Yew Tan
No abstract text is available yet for this article.
March 2024: HeartRhythm Case Reports
https://read.qxmd.com/read/38496474/a-panoramic-view-of-cell-population-dynamics-in-mammalian-aging
#27
Zehao Zhang, Chloe Schaefer, Weirong Jiang, Ziyu Lu, Jasper Lee, Andras Sziraki, Abdulraouf Abdulraouf, Brittney Wick, Maximilian Haeussler, Zhuoyan Li, Gesmira Molla, Rahul Satija, Wei Zhou, Junyue Cao
UNLABELLED: To elucidate the aging-associated cellular population dynamics throughout the body, here we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissue samples, encompassing a range of organs across different life stages, sexes, and genotypes. This comprehensive dataset allowed us to identify more than 3,000 unique cellular states and catalog over 200 distinct aging-associated cell populations experiencing significant depletion or expansion...
March 5, 2024: bioRxiv
https://read.qxmd.com/read/38496250/symposium-summary-epigenetic-inheritance-impact-for-biology-and-society-23-25-august-2023-z%C3%A3-rich-switzerland
#28
JOURNAL ARTICLE
Leonard C Steg, Ellen Jaspers, Anar Alshanbayeva, Rodrigo G Arzate-Meija, Maria A Dimitriu, Katharina Gapp, Lola M Kourouma, Kerem Uzel, Isabelle M Mansuy
The possibility that acquired traits can be transmitted across generations has been the subject of intense research in the past decades. This biological process is of major interest to many scientists and has profound implications for biology and society but has complex mechanisms and is therefore challenging to study. Because it involves factors independent from the DNA sequence, this form of heredity is classically referred to as epigenetic inheritance. Many studies have examined how life experiences and various environmental factors can cause phenotypes that are heritable and be manifested in subsequent generations...
2024: Environmental Epigenetics
https://read.qxmd.com/read/38488382/treating-hypertension-important-for-heart-health-fundamental-for-brain-health
#29
JOURNAL ARTICLE
Sanjula D Singh, Jasper R Senff, Cornelia M van Duijn, Jonathan Rosand
The Brain Health crisis stands as one of humankind's most pressing threats, with age-related noncommunicable brain diseases, particularly stroke, and dementia, affecting hundreds of millions annually and jeopardizing the economic well-being of populations worldwide. Epidemiological studies indicate that ≈40% of dementia and 60% of stroke cases are attributable to modifiable risk factors. In this Comments and Opinions article, we underscore the pivotal role of blood pressure (BP) control in reducing suffering, enhancing economic well-being, and promoting healthy longevity for populations worldwide...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38487876/long-term-outcomes-in-patients-with-spontaneous-cerebellar-hemorrhage-an-international-cohort-study
#30
JOURNAL ARTICLE
Jasper R Senff, Sanjula D Singh, Marco Pasi, Wilmar M T Jolink, Mark A Rodrigues, Floris H B M Schreuder, Julie Staals, Tobien Schreuder, Jules P J Douwes, Jelmer Talsma, Brenna N McKaig, Christina Kourkoulis, Nirupama Yechoor, Christopher D Anderson, Laurent Puy, Charlotte Cordonnier, Marieke J H Wermer, Peter M Rothwell, Jonathan Rosand, Catharina J M Klijn, Rustam Al-Shahi Salman, Gabriël J E Rinkel, Anand Viswanathan, Joshua N Goldstein, H Bart Brouwers
BACKGROUND: Spontaneous intracerebral hemorrhage (ICH) in the cerebellum has a poor short-term prognosis, whereas data on the long-term case fatality and recurrent vascular events are sparse. Herewith, we aimed to assess the long-term case fatality and recurrence rate of vascular events after a first cerebellar ICH. METHODS: In this international cohort study, we included patients from 10 hospitals (the United States and Europe from 1997 to 2017) aged ≥18 years with a first spontaneous cerebellar ICH who were discharged alive...
March 15, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38485435/shifts-in-phytoplankton-and-zooplankton-communities-in-three-cyanobacteria-dominated-lakes-after-treatment-with-hydrogen-peroxide
#31
JOURNAL ARTICLE
Tim Piel, Giovanni Sandrini, Erik F J Weenink, Hongjie Qin, Maria J van Herk, Mariël Léon Morales-Grooters, J Merijn Schuurmans, Pieter C Slot, Geert Wijn, Jasper Arntz, Sevasti-Kiriaki Zervou, Triantafyllos Kaloudis, Anastasia Hiskia, Jef Huisman, Petra M Visser
Cyanobacteria can reach high densities in eutrophic lakes, which may cause problems due to their potential toxin production. Several methods are in use to prevent, control or mitigate harmful cyanobacterial blooms. Treatment of blooms with low concentrations of hydrogen peroxide (H2 O2 ) is a promising emergency method. However, effects of H2 O2 on cyanobacteria, eukaryotic phytoplankton and zooplankton have mainly been studied in controlled cultures and mesocosm experiments, while much less is known about the effectiveness and potential side effects of H2 O2 treatments on entire lake ecosystems...
March 2024: Harmful Algae
https://read.qxmd.com/read/38483996/structural-insights-reveal-interplay-between-lag-3-homodimerization-ligand-binding-and-function
#32
JOURNAL ARTICLE
John L Silberstein, Jasper Du, Kun-Wei Chan, Jessica A Frank, Irimpan I Mathews, Yong Bin Kim, Jia You, Qiao Lu, Jia Liu, Elliot A Philips, Phillip Liu, Eric Rao, Daniel Fernandez, Grayson E Rodriguez, Xiang-Peng Kong, Jun Wang, Jennifer R Cochran
Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor expressed on activated T cells and an emerging immunotherapy target. Domain 1 (D1) of LAG-3, which has been purported to directly interact with major histocompatibility complex class II (MHCII) and fibrinogen-like protein 1 (FGL1), has been the major focus for the development of therapeutic antibodies that inhibit LAG-3 receptor-ligand interactions and restore T cell function. Here, we present a high-resolution structure of glycosylated mouse LAG-3 ectodomain, identifying that cis-homodimerization, mediated through a network of hydrophobic residues within domain 2 (D2), is critically required for LAG-3 function...
March 19, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38482665/robotic-versus-laparoscopic-liver-resection-in-various-settings-an-international-multicenter-propensity-score-matched-study-of-10-075-patients
#33
JOURNAL ARTICLE
Jasper P Sijberden, Tijs J Hoogteijling, Davit Aghayan, Francesca Ratti, Ek-Khoon Tan, Victoria Morrison-Jones, Jacopo Lanari, Louis Haentjens, Kongyuan Wei, Stylianos Tzedakis, John Martinie, Daniel Osei Bordom, Giuseppe Zimmitti, Kaitlyn Crespo, Paolo Magistri, Nadia Russolillo, Simone Conci, Burak Görgec, Andrea Benedetti Cacciaguerra, Daniel D'Souza, Gabriel Zozaya, Cèlia Caula, David Geller, Ricardo Robles Campos, Roland Croner, Shafiq Rehman, Elio Jovine, Mikhail Efanov, Adnan Alseidi, Riccardo Memeo, Ibrahim Dagher, Felice Giuliante, Ernesto Sparrelid, Jawad Ahmad, Tom Gallagher, Moritz Schmelzle, Rutger-Jan Swijnenburg, Åsmund Avdem Fretland, Federica Cipriani, Ye-Xin Koh, Steven White, Santi Lopez Ben, Fernando Rotellar, Pablo E Serrano, Marco Vivarelli, Andrea Ruzzenente, Alessandro Ferrero, Fabrizio Di Benedetto, Marc G Besselink, Iswanto Sucandy, Robert P Sutcliffe, Dionisios Vrochides, David Fuks, Rong Liu, Mathieu D'Hondt, Umberto Cillo, John N Primrose, Brian K P Goh, Luca A Aldrighetti, Bjørn Edwin, Mohammad Abu Hilal
OBJECTIVE: The aim of this study was to compare the perioperative outcomes of robotic liver surgery (RLS) and laparoscopic liver surgery (LLS) in various settings. SUMMARY BACKGROUND DATA: Clear advantages of RLS over LLS have rarely been demonstrated, and the associated costs of robotic surgery are generally higher than those of laparoscopic surgery. Therefore, the exact role of the robotic approach in minimally invasive liver surgery remains to be defined. METHODS: In this international retrospective cohort study, the outcomes of patients who underwent RLS and LLS for all indications between 2009 and 2021 in 34 hepatobiliary referral centers were compared...
March 14, 2024: Annals of Surgery
https://read.qxmd.com/read/38481596/automatic-hepatic-tumor-segmentation-in-intra-operative-ultrasound-a-supervised-deep-learning-approach
#34
JOURNAL ARTICLE
Tiziano Natali, Andrey Zhylka, Karin Olthof, Jasper N Smit, Tarik R Baetens, Niels F M Kok, Koert F D Kuhlmann, Oleksandra Ivashchenko, Theo J M Ruers, Matteo Fusaglia
PURPOSE: Training and evaluation of the performance of a supervised deep-learning model for the segmentation of hepatic tumors from intraoperative US (iUS) images, with the purpose of improving the accuracy of tumor margin assessment during liver surgeries and the detection of lesions during colorectal surgeries. APPROACH: In this retrospective study, a U-Net network was trained with the nnU-Net framework in different configurations for the segmentation of CRLM from iUS...
March 2024: Journal of Medical Imaging
https://read.qxmd.com/read/38478590/eels-autonomous-snake-like-robot-with-task-and-motion-planning-capabilities-for-ice-world-exploration
#35
JOURNAL ARTICLE
T S Vaquero, G Daddi, R Thakker, M Paton, A Jasour, M P Strub, R M Swan, R Royce, M Gildner, P Tosi, M Veismann, P Gavrilov, E Marteau, J Bowkett, D Loret de Mola Lemus, Y Nakka, B Hockman, A Orekhov, T D Hasseler, C Leake, B Nuernberger, P Proença, W Reid, W Talbot, N Georgiev, T Pailevanian, A Archanian, E Ambrose, J Jasper, R Etheredge, C Roman, D Levine, K Otsu, S Yearicks, H Melikyan, R R Rieber, K Carpenter, J Nash, A Jain, L Shiraishi, M Robinson, M Travers, H Choset, J Burdick, A Gardner, M Cable, M Ingham, M Ono
Ice worlds are at the forefront of astrobiological interest because of the evidence of subsurface oceans. Enceladus in particular is unique among the icy moons because there are known vent systems that are likely connected to a subsurface ocean, through which the ocean water is ejected to space. An existing study has shown that sending small robots into the vents and directly sampling the ocean water is likely possible. To enable such a mission, NASA's Jet Propulsion Laboratory is developing a snake-like robot called Exobiology Extant Life Surveyor (EELS) that can navigate Enceladus' extreme surface and descend an erupting vent to capture unaltered liquid samples and potentially reach the ocean...
March 13, 2024: Science Robotics
https://read.qxmd.com/read/38476454/a-case-report-of-two-synchronous-primary-urologic-malignancies-in-one-patient
#36
Alex Mremi, Janeth Mpelumbe, Furaha Enos Kasyupa, Elizabeth Patrick, Orgeness Jasper Mbwambo, Bartholomeo Nicholaus Ngowi
It is quite unusual to have numerous primary malignant tumors at the same time in the same patient. These cancers are classified as metachronous or synchronous. The occurrence of synchronous urologic tumors poses diagnostic and treatment challenges and has always been a subject of controversy in the clinical decision-making process. Unfortunately, no clear standardized management protocols for these patients exist. Therefore, diagnosis and treatment may be difficult, especially with few resources. We present a 75-year-old man with simultaneous prostate and kidney cancers successfully treated at our center...
March 2024: Journal of Surgical Case Reports
https://read.qxmd.com/read/38473218/skull-base-chondrosarcoma-a-systematic-review-of-the-role-of-postoperative-radiotherapy
#37
REVIEW
Pawan Kishore Ravindran, Max E Keizer, Henricus Dirk P M Kunst, Inge Compter, Jasper Van Aalst, Daniëlle B P Eekers, Yasin Temel
Surgery and radiotherapy are key elements to the treatment of skull-base chondrosarcomas; however, there is currently no consensus regarding whether or not adjuvant radiotherapy has to be administered. This study searched the EMBASE, Cochrane, and PubMed databases for clinical studies evaluating the long-term prognosis of surgery with or without adjuvant radiotherapy. After reviewing the search results, a total of 22 articles were selected for this review. A total of 1388 patients were included in this cohort, of which 186 received surgery only...
February 21, 2024: Cancers
https://read.qxmd.com/read/38472696/effect-of-daridorexant-on-the-pharmacokinetics-of-midazolam-and-on-the-pharmacokinetics-and-pharmacodynamics-of-warfarin-in-healthy-male-subjects
#38
JOURNAL ARTICLE
Isabelle Zenklusen, Jasper Dingemanse, Christian Reh, Martine Gehin, Priska Kaufmann
BACKGROUND AND OBJECTIVES: Daridorexant, a dual orexin receptor antagonist was recently approved for the treatment of insomnia at doses up to 50 mg once per night. This study investigated the effect of single-dose and multiple-dose daridorexant 50 mg at steady state on the pharmacokinetics (PK) of the cytochrome P450 (CYP) 3A4-sensitive substrate midazolam, and the effect of single-dose daridorexant 50 mg on the PK and pharmacodynamics (PD) of the CYP2C9-sensitive substrate warfarin...
March 13, 2024: Drugs in R&D
https://read.qxmd.com/read/38472040/clinical-application-and-further-development-of-augmented-reality-guidance-for-the-surgical-localization-of-pediatric-chest-wall-tumors
#39
JOURNAL ARTICLE
Rémi van der Woude, Matthijs Fitski, Jasper M van der Zee, Cornelis P van de Ven, Guus M J Bökkerink, Marc H W A Wijnen, Jene W Meulstee, Tristan P C van Doormaal, Françoise J Siepel, Alida F W van der Steeg
BACKGROUND: Surgical treatment of pediatric chest wall tumors requires accurate surgical planning and tumor localization to achieve radical resections while sparing as much healthy tissue as possible. Augmented Reality (AR) could facilitate surgical decision making by improving anatomical understanding and intraoperative tumor localization. We present our clinical experience with the use of an AR system for intraoperative tumor localization during chest wall resections. Furthermore, we present the pre-clinical results of a new registration method to improve our conventional AR system...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38471989/influence-of-nitrous-oxide-added-to-general-anaesthesia-on-postoperative-mortality-and-morbidity-a-systematic-review-and-meta-analysis
#40
REVIEW
Jasper M Kampman, Kim Y Q Plasmans, Jeroen Hermanides, Markus W Hollmann, Sjoerd Repping, Nicolaas H Sperna Weiland
BACKGROUND: Nitrous oxide (N2 O) is a common adjuvant to general anaesthesia. It is also a potent greenhouse gas and causes ozone depletion. We sought to quantify the influence of N2 O as an adjuvant to general anaesthesia on postoperative patient outcomes. METHODS: We searched Medline, EMBASE, and Cochrane Central for works published from inception to July 6, 2023. RCTs comparing general anaesthesia with or without N2 O were included. Risk ratios (RRs) and standardised mean differences (SMDs) were calculated, along with 95% confidence intervals (CIs), using a random-effects model...
March 11, 2024: British Journal of Anaesthesia
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