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https://www.readbyqxmd.com/read/28320607/diagnostic-value-of-st-segment-deviations-during-cardiac-exercise-stress-testing-systematic-comparison-of-different-ecg-leads-and-time-points
#1
Christian Puelacher, Max Wagener, Roger Abächerli, Ursina Honegger, Nundsin Lhasam, Nicolas Schaerli, Gil Prêtre, Ivo Strebel, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Maria Rubini Giménez, Petra Hillinger, Karin Wildi, Zaid Sabti, Patrick Badertscher, Janosch Cupa, Nikola Kozhuharov, Jeanne du Fay de Lavallaz, Michael Freese, Isabelle Roux, Jens Lohrmann, Remo Leber, Stefan Osswald, Damian Wild, Michael J Zellweger, Christian Mueller, Tobias Reichlin
BACKGROUND: Exercise ECG stress testing is the most widely available method for evaluation of patients with suspected myocardial ischemia. Its major limitation is the relatively poor accuracy of ST-segment changes regarding ischemia detection. Little is known about the optimal method to assess ST-deviations. METHODS: A total of 1558 consecutive patients undergoing bicycle exercise stress myocardial perfusion imaging (MPI) were enrolled. Presence of inducible myocardial ischemia was adjudicated using MPI results...
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28320422/do-associations-between-objectively-assessed-physical-activity-and-neighbourhood-environment-attributes-vary-by-time-of-the-day-and-day-of-the-week-ipen-adult-study
#2
Ester Cerin, Josef Mitáš, Kelli L Cain, Terry L Conway, Marc A Adams, Grant Schofield, Olga L Sarmiento, Rodrigo Siqueira Reis, Jasper Schipperijn, Rachel Davey, Deborah Salvo, Rosario Orzanco-Garralda, Duncan J Macfarlane, Ilse De Bourdeaudhuij, Neville Owen, James F Sallis, Delfien Van Dyck
BACKGROUND: To more accurately quantify the potential impact of the neighbourhood environment on adults' physical activity (PA), it is important to compare environment-PA associations between periods of the day or week when adults are more versus less likely to be in their neighbourhood and utilise its PA resources. We examined whether, among adults from 10 countries, associations between objectively-assessed neighbourhood environment attributes and moderate-to-vigorous physical activity (MVPA) varied by time of the day and day of the week...
March 20, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28319403/deposition-of-a-cationic-fe-iii-spin-crossover-complex-on-au-111-impact-of-the-counter-ion
#3
Torben Jasper-Toennies, Manuel Gruber, Sujoy Karan, Hanne Jacob, Felix Tuczek, Richard Berndt
Spin-crossover molecules on metallic substrates have recently attracted considerable interest for their potential applications in molecular spintronics. Using scanning tunneling microscopy, we evidence the first successful deposition of a charged FeIII spin-crossover complex, [Fe(pap)2 ]+ (pap=N-2-pyridylmethylidene-2- hydroxyphenylaminato), on Au(111). Furthermore, the bulk form of the molecules is stabilized by a perchlorate counter ion, which depending on the deposition technique, may affect the quality of the deposition and the measurements...
March 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28318000/in-situ-observation-of-self-assembly-of-sugars-and-surfactants-from-nanometres-to-microns
#4
Samia Ouhajji, Jasper Landman, Sylvain Prévost, Lingxiang Jiang, Albert P Philipse, Andrei V Petukhov
The hierarchical self-assembly of sugar and surfactant molecules into hollow tubular microstructures was characterized in situ with high resolution small-angle X-ray scattering spanning more than three orders of magnitude of spatial scales. Scattering profiles reveal that aqueous host-guest inclusion complexes self-assemble into multiple equally spaced curved bilayers forming a collection of concentric hollow cylinders. Scattering data can be described by a simple theoretical model of the microtubes. The interlamellar distance was found to be surprisingly large...
March 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28316941/acute-kidney-injury-following-spinal-instrumentation-surgery-in-children
#5
Jasper J Jöbsis, Abdullah Alabbas, Ruth Milner, Christopher Reilly, Kishore Mulpuri, Cherry Mammen
AIM: To determine acute kidney in jury (AKI) incidence and potential risk factors of AKI in children undergoing spinal instrumentation surgery. METHODS: AKI incidence in children undergoing spinal instrumentation surgery at British Columbia Children's Hospital between January 2006 and December 2008 was determined by the Acute Kidney Injury Networ classification using serum creatinine and urine output criteria. During this specific time period, all patients following spinal surgery were monitored in the pediatric intensive care unit and had an indwelling Foley catheter permitting hourly urine output recording...
March 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28316344/mechanoluminescent-imaging-of-osmotic-stress-induced-damage-in-a-glassy-polymer-network
#6
Jess M Clough, Jasper van der Gucht, Rint P Sijbesma
A chemiluminescent mechanophore, bis(adamantyl-1,2-dioxetane), is used to investigate the covalent bond scission resulting from the sorption of chloroform by glassy poly(methyl methacrylate) (PMMA) networks. Bis(adamantyl)-1,2-dioxetane units incorporated as cross-linkers underwent mechanoluminescent scission, demonstrating that solvent ingress caused covalent bond scission. At higher cross-linking densities, the light emission took the form of hundreds of discrete bursts, widely varying in intensity, with each burst composed of 10(7)-10(9) photons...
March 14, 2017: Macromolecules
https://www.readbyqxmd.com/read/28315809/identifying-attendance-patterns-in-a-smoking-cessation-treatment-and-their-relationships-with-quit-success
#7
Jolene Jacquart, Santiago Papini, Michelle L Davis, David Rosenfield, Mark B Powers, Georita M Frierson, Lindsey B Hopkins, Scarlett O Baird, Bess H Marcus, Timothy S Church, Michael W Otto, Michael J Zvolensky, Jasper A J Smits
BACKGROUND: While important for substance use outcomes, knowledge about treatment attendance patterns, and their relation with clinical outcomes is limited. We examined the association between attendance patterns and smoking outcomes in a randomized, controlled smoking cessation intervention trial. METHODS: In addition to standard smoking cessation treatment, participants were randomized to 15 weeks of an exercise intervention (n=72) or an education control condition (n=64)...
March 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28306503/phase-separation-of-c9orf72-dipeptide-repeats-perturbs-stress-granule-dynamics
#8
Steven Boeynaems, Elke Bogaert, Denes Kovacs, Albert Konijnenberg, Evy Timmerman, Alex Volkov, Mainak Guharoy, Mathias De Decker, Tom Jaspers, Veronica H Ryan, Abigail M Janke, Pieter Baatsen, Thomas Vercruysse, Regina-Maria Kolaitis, Dirk Daelemans, J Paul Taylor, Nancy Kedersha, Paul Anderson, Francis Impens, Frank Sobott, Joost Schymkowitz, Frederic Rousseau, Nicolas L Fawzi, Wim Robberecht, Philip Van Damme, Peter Tompa, Ludo Van Den Bosch
Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules. Defects in stress granule homeostasis constitute a cornerstone of ALS/FTLD pathogenesis. Polar residues (tyrosine and glutamine) have been previously demonstrated to be critical for phase separation of ALS-linked stress granule proteins. We now identify an active role for arginine-rich domains in these phase separations...
March 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28304329/a-student-s-guide-to-giant-viruses-infecting-small-eukaryotes-from-acanthamoeba-to-zooxanthellae
#9
REVIEW
Steven W Wilhelm, Jordan T Bird, Kyle S Bonifer, Benjamin C Calfee, Tian Chen, Samantha R Coy, P Jackson Gainer, Eric R Gann, Huston T Heatherly, Jasper Lee, Xiaolong Liang, Jiang Liu, April C Armes, Mohammad Moniruzzaman, J Hunter Rice, Joshua M A Stough, Robert N Tams, Evan P Williams, Gary R LeCleir
The discovery of infectious particles that challenge conventional thoughts concerning "what is a virus" has led to the evolution a new field of study in the past decade. Here, we review knowledge and information concerning "giant viruses", with a focus not only on some of the best studied systems, but also provide an effort to illuminate systems yet to be better resolved. We conclude by demonstrating that there is an abundance of new host-virus systems that fall into this "giant" category, demonstrating that this field of inquiry presents great opportunities for future research...
March 17, 2017: Viruses
https://www.readbyqxmd.com/read/28302853/aggregation-of-the-whi3-protein-not-loss-of-heterochromatin-causes-sterility-in-old-yeast-cells
#10
Gavin Schlissel, Marek K Krzyzanowski, Fabrice Caudron, Yves Barral, Jasper Rine
In yeast, heterochromatin silencing is reported to decline in aging mother cells, causing sterility in old cells. This process is thought to reflect a decrease in the activity of the NAD(+) (oxidized nicotinamide adenine dinucleotide)-dependent deacetylase Sir2. We tested whether Sir2 becomes nonfunctional gradually or precipitously during aging. Unexpectedly, silencing of the heterochromatic HML and HMR loci was not lost during aging. Old cells could initiate a mating response; however, they were less sensitive to mating pheromone than were young cells because of age-dependent aggregation of Whi3, an RNA-binding protein controlling S-phase entry...
March 17, 2017: Science
https://www.readbyqxmd.com/read/28293876/changes-in-the-mitochondrial-function-and-in-the-efficiency-of-energy-transfer-pathways-during-cardiomyocyte-aging
#11
Kersti Tepp, Marju Puurand, Natalja Timohhina, Jasper Adamson, Aleksandr Klepinin, Laura Truu, Igor Shevchuk, Vladimir Chekulayev, Tuuli Kaambre
The role of mitochondria in alterations that take place in the muscle cell during healthy aging is a matter of debate during recent years. Most of the studies in bioenergetics have a focus on the model of isolated mitochondria, while changes in the crosstalk between working myofibrils and mitochondria in senescent cardiomyocytes have been less studied. The aim of our research was to investigate the modifications in the highly regulated ATP production and energy transfer systems in heart cells in old rat cardiomyocytes...
March 14, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28283497/direct-comparison-of-four-very-early-rule-out-strategies-for-acute-myocardial-infarction-using-high-sensitivity-cardiac-troponin-i
#12
Jasper Boeddinghaus, Thomas Nestelberger, Raphael Twerenbold, Karin Wildi, Patrick Badertscher, Janosch Cupa, Tobias Bürge, Patrick Mächler, Sydney Corbière, Karin Grimm, Maria Rubini Giménez, Christian Puelacher, Samyut Shrestha, Dayana Flores Widmer, Jakob Fuhrmann, Petra Hillinger, Zaid Sabti, Ursina Honegger, Nicolas Schaerli, Nikola Kozhuharov, Katharina Rentsch, Òscar Miró, Beatriz López Barbeito, F Javier Martin-Sanchez, Esther Rodriguez-Adrada, Beata Morawiec, Damian Kawecki, Eva Ganovská, Jiri Parenica, Jens Lohrmann, Wanda Kloos, Andreas Buser, Nicolas Geigy, Dagmar I Keller, Stefan Osswald, Tobias Reichlin, Christian Müller
Background -Four strategies for very early rule-out of acute myocardial infarction (AMI) using high-sensitivity cardiac troponin I (hs-cTnI) have been identified. It remains unclear which strategy is most attractive for clinical application. Methods -We prospectively enrolled unselected patients presenting to the emergency department (ED) with symptoms suggestive of AMI. The final diagnosis was adjudicated by two independent cardiologists. Hs-cTnI levels were measured at presentation and after 1h in a blinded fashion...
March 10, 2017: Circulation
https://www.readbyqxmd.com/read/28282097/screening-metal-organic-frameworks-for-separation-of-pentane-isomers
#13
Rajamani Krishna, Jasper M van Baten
This article compares the performances of several metal-organic frameworks (MOFs) and zeolitic imidazolate frameworks (ZIFs) for the separation of pentane isomers: n-pentane (nC5), 2-methylbutane (2MB), and 2,2-dimethylpropane (= neo-pentane (neo-P)) in fixed bed adsorbers. The required input data on unary and mixture adsorption equilibria are obtained from Configurational-Bias Monte Carlo (CBMC) simulations for twelve different adsorbents. The best separation performance is realized with Fe2(BDP)3, where BDP(2-) = 1,4-benzenedipyrazolate, a MOF with triangular shaped 4...
March 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28281146/influence-of-the-cardiac-cycle-on-pcasl-cardiac-triggering-of-the-end-of-labeling
#14
Jasper Verbree, Matthias J P van Osch
OBJECTIVE: In arterial spin labeling (ASL), the cardiac cycle might adversely influence signal-stability by varying the amount of label created, labeling efficiency and/or transport times. Due to the long labeling duration in pseudo-Continuous ASL (pCASL), the blood labeled last contributes most to the ASLsignal. The present study investigated, using numerical simulations and in vivo experiments, the effect of the cardiac cycle on pCASL, thereby focusing on the end-of-labeling. MATERIALS AND METHODS: In the in vivo experiments the end-of-labeling was timed to a specific cardiac phase while a long labeling duration of >7 s was used to isolate the influence of the lastly labeled spins on ASL-signal stability...
March 9, 2017: Magma
https://www.readbyqxmd.com/read/28275136/distinct-and-overlapping-functions-of-tec-kinase-and-btk-in-b-cell-receptor-signaling
#15
Marjolein J W de Bruijn, Jasper Rip, Esmee K van der Ploeg, Lars W van Greuningen, Van T B Ta, Laurens P Kil, Anton W Langerak, Guus F Rimmelzwaan, Wilfried Ellmeier, Rudi W Hendriks, Odilia B J Corneth
The Tec tyrosine kinase is expressed in many cell types, including hematopoietic cells, and is a member of the Tec kinase family that also includes Btk. Although the role of Btk in B cells has been extensively studied, the role of Tec kinase in B cells remains largely unclear. It was previously shown that Tec kinase has the ability to partly compensate for loss of Btk activity in B cell differentiation, although the underlying mechanism is unknown. In this study, we confirm that Tec kinase is not essential for normal B cell development when Btk is present, but we also found that Tec-deficient mature B cells showed increased activation, proliferation, and survival upon BCR stimulation, even in the presence of Btk...
March 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28272648/on-teaching-international-courses-on-health-information-systems-lessons-learned-during-16-years-of-frank-van-swieten-lectures-on-strategic-information-management-in-health-information-systems
#16
Elske Ammenwerth, Petra Knaup, Alfred Winter, Axel W Bauer, Oliver J Bott, Matthias Gietzelt, Birger Haarbrandt, Werner O Hackl, Nils Hellrung, Gudrun Hübner-Bloder, Franziska Jahn, Monique W Jaspers, Ulrike Kutscha, Christoph Machan, Bianca Oppermann, Jochen Pilz, Jonas Schwartze, Christoph Seidel, Jan-Eric Slot, Stefan Smers, Katharina Spitalewsky, Nathalie Steckel, Alexander Strübing, Minne van der Haak, Reinhold Haux, Willem J Ter Burg
BACKGROUND: Health information systems (HIS) are one of the most important areas for biomedical and health informatics. In order to professionally deal with HIS well-educated informaticians are needed. Because of these reasons, in 2001 an international course has been established: The Frank - van Swieten Lectures on Strategic Information Management of Health Information Systems. OBJECTIVES: Reporting about the Frank - van Swieten Lectures and about our students' feedback on this course during the last 16 years...
March 8, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28267974/epithelia-understanding-the-cell-biology-of-intestinal-barrier-dysfunction
#17
Daniel J-K Hu, Heinrich Jasper
Barrier dysfunction in the intestine is a common characteristic of aging organisms. A recent study provides new insight into the cell biology of this phenomenon.
March 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28264807/unusual-presentation-of-a-late-onset-recurrence-of-malignant-peritoneal-mesothelioma
#18
Marije Wijnberge, Lidewine Daniels, Vincent Cliteur, Jasper Winkelhagen
A man aged 79 years with a history of malignant peritoneal mesothelioma presented 8 years after primary presentation with a suspected right-sided painful inguinal hernia and hydrocele, both present for 5 months. During surgery, however, the inguinal swelling appeared to be a tumour. Laboratory examination was non-alarming and ultrasonography not specific for mesothelioma. Pathological examination showed it to be a recurrence of the malignant mesothelioma, which was treated palliative with radiotherapy. This clinical picture is rare and a recurrence-free survival of 8 years is remarkable...
March 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28256441/supine-breast-mri-using-respiratory-triggering
#19
Natasja N Y Janssen, Leon C Ter Beek, Claudette E Loo, Gonneke Winter-Warnars, Charlotte A H Lange, Marjolein van Loveren, Tanja Alderliesten, Jan-Jakob Sonke, Jasper Nijkamp
RATIONALE AND OBJECTIVES: This study aims to evaluate if navigator-echo respiratory-triggered magnetic resonance acquisition can acquire supine high-quality breast magnetic resonance imaging (MRI). MATERIALS AND METHODS: Supine respiratory-triggered magnetic resonance imaging (Trig-MRI) was compared to supine non-Trig-MRI to evaluate breathing-induced motion artifacts (group 1), and to conventional prone non-Trig-MRI (group 2, 16-channel breast coil), all at 3T...
February 27, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28253072/gender-differences-in-the-domain-specific-contributions-to-mvpa-accessed-by-gps
#20
Andreia Nogueira Pizarro, Jasper Schipperijn, José Carlos Ribeiro, António Figueiredo, Jorge Mota, Maria Paula Santos
BACKGROUND: Identifying where children spend their activity-time may help define relevant domains for effective PA promotion and better understand the relation between PA and environment. Our study aimed to identify how boys and girls allocate their active time in the different domains. METHODS: 374 children (201 girls; X=11.7y) wore an accelerometer and a GPS for 7 days. PALMS software combined data, categorized non-sedentary time and bouts of moderate-to-vigorous physical activity (MVPA)...
March 2, 2017: Journal of Physical Activity & Health
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