keyword
MENU ▼
Read by QxMD icon Read
search

Jaspers

keyword
https://www.readbyqxmd.com/read/28737056/quantification-of-human-brain-pde4-occupancy-by-gsk356278-a-11-c-r-rolipram-pet-study
#1
Jasper van der Aart, Cristian Salinas, Rahul Dimber, Sabina Pampols-Maso, Ashley A Weekes, John Tonkyn, Frank A Gray, Jan Passchier, Roger N Gunn, Eugenii A Rabiner
We characterized the relationship between the plasma concentration of the phospodiesterase (PDE)-4 inhibitor GSK356278 and occupancy of the PDE4 enzyme in the brain of healthy volunteers, using the positron emission tomography (PET) tracer [(11)C](R)-rolipram. To this end, PET scans were acquired in eight male volunteers before and at 3 and 8 h after a single 14 mg oral dose of GSK356278. A metabolite-corrected arterial input function was used in conjunction with the dynamic PET emission data to estimate volumes of distribution (VT) from a two-tissue compartment model...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28731653/insulin-level-and-insulin-sensitivity-indices-among-healthy-children-and-adolescents
#2
María G Ballerini, Ignacio Bergadá, María E Rodríguez, Ana Keselman, Viviana S Bengolea, Viviana Pipman, Horacio M Domené, Héctor G Jasper, María G Ropelato
INTRODUCTION: Information on insulin reference values and insulin sensitivity indices in the field of pediatrics is scarce. OBJETIVE: To describe insulin range and insulin sensitivity surrogate indices during childhood. POPULATION AND METHODS: Fasting insulin level range and surrogate indices, such as the homeostasis model assessment of insulin resistance (HOMA-IR), among healthy children and adolescents by age, body mass index, pubertal stage (PS), insulin-like growth factor-1 (IGF-1), total cholesterol, and triglycerides...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28728672/blue-laser-imaging-a-promising-new-kid-on-the-block-or-another-tool-to-increase-detection-of-low-risk-adenomas
#3
EDITORIAL
Jasper L A Vleugels, Evelien Dekker
No abstract text is available yet for this article.
August 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28727205/drivers-of-woody-canopy-water-content-responses-to-drought-in-a-mediterranean-type-ecosystem
#4
Tarin Paz-Kagan, Gregory P Asner
Severe droughts increase physiological stress in woody plant species, which can lead to mortality, fundamentally altering the composition, structure, and biogeography of forests in many regions. Little is known, however, about the factors determining the physiological response of woody plants to drought at landscape scales. Our objective was to understand woody plant species responses to ongoing changes in climate, using remotely sensed canopy water content (CWC) as an indicator of plant physiological and phenological status...
July 20, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28726801/accumbens-mechanisms-for-cued-sucrose-seeking
#5
Ana-Clara Bobadilla, Constanza Garcia-Keller, Jasper A Heinsbroek, Michael Scofield, Victoria Chareunsouk, Cara Monforton, Peter W Kalivas
Many studies support a perspective that addictive drugs usurp brain circuits used by natural rewards, especially for the dopamine-dependent reinforcing qualities of both drugs and natural rewards. Reinstated drug seeking in animal models of relapse relies on glutamate spillover from cortical terminals synapsing in the nucleus accumbens core (NAcore) to stimulate metabotropic glutamate receptor5 (mGluR5) on neuronal nitric oxide synthase (nNOS) interneurons. Contrasting the release of dopamine that is shared by sucrose and drugs of abuse, reinstated sucrose seeking does not induce glutamate spillover...
July 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28723736/timing-of-preoperative-antibiotic-prophylaxis-in-54-552-patients-and-the-risk-of-surgical-site-infection-a-systematic-review-and-meta-analysis
#6
Stijn Willem de Jonge, Sarah L Gans, Jasper J Atema, Joseph S Solomkin, Patchen E Dellinger, Marja A Boermeester
The aim of the study was to assess the effect of timing of preoperative surgical antibiotic prophylaxis (SAP) on surgical site infection (SSI) and compare the different timing intervals.The benefit of routine use of SAP prior to surgery has long been recognized. However, the optimal timing has not been defined. For the purpose of developing recommendations for the World Health Organization guideline for SSI prevention, a systematic review and meta-analysis of all relevant evidence was conducted.Major medical databases were searched from 1990 to 2016...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28721436/age-at-natural-menopause-and-risk-of-type-2-diabetes-a-prospective-cohort-study
#7
Taulant Muka, Eralda Asllanaj, Naim Avazverdi, Loes Jaspers, Najada Stringa, Jelena Milic, Symen Ligthart, M Arfan Ikram, Joop S E Laven, Maryam Kavousi, Abbas Dehghan, Oscar H Franco
AIMS/HYPOTHESIS: In this study, we aimed to examine the association between age at natural menopause and risk of type 2 diabetes, and to assess whether this association is independent of potential mediators. METHODS: We included 3639 postmenopausal women from the prospective, population-based Rotterdam Study. Age at natural menopause was self-reported retrospectively and was treated as a continuous variable and in categories (premature, <40 years; early, 40-44 years; normal, 45-55 years; and late menopause, >55 years [reference])...
July 18, 2017: Diabetologia
https://www.readbyqxmd.com/read/28715853/effect-of-gemfibrozil-or-rifampicin-on-the-pharmacokinetics-of-selexipag-and-its-active-metabolite-in-healthy-subjects
#8
Shirin Bruderer, Marc Petersen-Sylla, Margaux Boehler, Tatiana Remeňová, Atef Halabi, Jasper Dingemanse
AIMS: Based on in vitro data CYP2C8 is involved in the metabolism of selexipag and its active metabolite, ACT-333679. The present study evaluated the possible pharmacokinetic interactions of selexipag with gemfibrozil, a strong CYP2C8 inhibitor and rifampicin, an inducer of CYP2C8. METHODS: The study consisted of two independent parts, each conducted according to an open-label, randomized crossover design. The pharmacokinetics and safety of selexipag and ACT-333679 were studied following single-dose administration either alone or in the presence of multiple-dose gemfibrozil (Part I) or rifampicin (Part II) in healthy male subjects...
July 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28712942/structure-based-discovery-of-clinically-approved-drugs-as-zika-virus-ns2b-ns3-protease-inhibitors-that-potently-inhibit-zika-virus-infection-in%C3%A2-vitro-and-in%C3%A2-vivo
#9
Shuofeng Yuan, Jasper Fuk-Woo Chan, Helena den-Haan, Kenn Ka-Heng Chik, Anna Jinxia Zhang, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Cyril Chik-Yan Yip, Winger Wing-Nga Mak, Zheng Zhu, Zijiao Zou, Kah-Meng Tee, Jian-Piao Cai, Kwok-Hung Chan, Jorge de la Peña, Horacio Pérez-Sánchez, José Pedro Cerón-Carrasco, Kwok-Yung Yuen
Zika virus (ZIKV) infection may be associated with severe complications in fetuses and adults, but treatment options are limited. We performed an in silico structure-based screening of a large chemical library to identify potential ZIKV NS2B-NS3 protease inhibitors. Clinically approved drugs belonging to different drug classes were selected among the 100 primary hit compounds with the highest predicted binding affinities to ZIKV NS2B-NS3-protease for validation studies. ZIKV NS2B-NS3 protease inhibitory activity was validated in most of the selected drugs and in vitro anti-ZIKV activity was identified in two of them (novobiocin and lopinavir-ritonavir)...
July 14, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28709881/can-primary-care-for-back-and-or-neck-pain-in-the-netherlands-benefit-from-stratification-for-risk-groups-according-to-the-start-back-tool-classification
#10
Jasper D Bier, Janneke J W Sandee-Geurts, Raymond W J G Ostelo, Bart W Koes, Arianne P Verhagen
OBJECTIVE: To evaluate whether current Dutch primary-care clinicians offer tailored treatment to patients with lower-back pain (LBP) or neck pain (NP) according to their risk stratification, based on the Keele STarT (Subgroup Targeted Treatment) Back-Screening Tool (SBT). DESIGN: Prospective cohort study with 3 month follow-up SETTING: Primary care PARTICIPANTS: General practitioners (GPs) and physiotherapists (PTs) included patients with non-specific LBP and/or NP...
July 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28704961/extraction-of-pathogenesis-related-proteins-and-phenolics-in-sauvignon-blanc-as-affected-by-grape-harvesting-and-processing-conditions
#11
Bin Tian, Roland Harrison, James Morton, Marlene Jaspers, Simon Hodge, Claire Grose, Mike Trought
Thaumatin-like proteins (TLPs) and chitinases are the two main groups of pathogenesis-related (PR) proteins found in wine that cause protein haze formation. Previous studies have found that phenolics are also involved in protein haze formation. In this study, Sauvignon Blanc grapes were harvested and processed in two vintages (2011 and 2012) by three different treatments: (1) hand harvesting with whole bunch press (H-WB); (2) hand harvesting with destem/crush and 3 h skin contact (H-DC-3); and (3) machine harvesting with destem/crush and 3 h skin contact (M-DC-3)...
July 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28704052/discovery-and-kinetic-profiling-of-7-aryl-1-2-4-triazolo-4-3-a-pyridines-positive-allosteric-modulators-of-the-metabotropic-glutamate-receptor-2
#12
Maarten L J Doornbos, José María Cid, Jordi Haubrich, Alexandro Nunes, Jasper W van de Sande, Sophie C Vermond, Thea Mulder-Krieger, Andrés A Trabanco, Abdellah Ahnaou, Wilhelmus H Drinkenburg, Hilde Lavreysen, Laura H Heitman, Adriaan P IJzerman, Gary Tresadern
We report the synthesis and biological evaluation of a series of 7-aryl-1,2,4-triazolo[4,3-a]pyridines with mGlu2 positive allosteric modulator (PAM) activity and affinity. Besides traditional in vitro parameters of potency and affinity, kinetic parameters kon, koff and residence time (RT) were determined. The PAMs showed various kinetic profiles; kon values ranged over two orders of magnitude, whereas RT values were within a 10-fold range. Association rate constant kon was linearly correlated to affinity. Evaluation of a short, medium and long RT compound in a label-free assay indicated a correlation between RT and functional effect...
July 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28702369/mutagenesis-of-threonine-to-serine-in-the-active-site-of-mycobacterium-tuberculosis-fructose-1-6-bisphosphatase-class-ii-retains-partial-enzyme-activity
#13
Jasper Marc G Bondoc, Nina M Wolf, Michael Ndichuck, Celerino Abad-Zapatero, Farahnaz Movahedzadeh
The glpX gene encodes for the Class II fructose-1,6-bisphosphatase enzyme in Mycobacterium tuberculosis (Mt), an essential enzyme for pathogenesis. We have performed site directed mutagenesis to introduce two mutations at residue Thr84, T84A and T84S, to explore the binding affinity of the substrate and the catalytic mechanism. The T84A mutant fully abolishes enzyme activity while retaining substrate binding affinity. In contrast, the T84S mutant retains some activity having a 10 times reduction in Vmax and exhibited similar sensitivity to lithium when compared to the wildtype...
September 2017: Biotechnology Reports
https://www.readbyqxmd.com/read/28701584/a-missing-voice-the-human-rights-of-children-to-a-tobacco-free-environment
#14
EDITORIAL
Brigit Toebes, Marie Elske Gispen, Jasper V Been, Aziz Sheikh
In this commentary, we flag the importance of taking a child-rights approach in the context of tobacco control, which is thus far unprecedented. This text was written in response to the Seventh Conference of States Parties of WHOs Framework Convention on Tobacco Control held in India from 7 to 12 November 2016.While the links between tobacco control and human rights were emphasised at this conference, a child-rights approach was missing. We argue that this novel angle provides important legal tools to protect the health and well-being of children...
July 12, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28696837/japanese-quail-coturnix-japonica-liver-and-thyroid-gland-histopathology-as-a-result-of-in-ovo-exposure-to-the-flame-retardants-tris-1-3-dichloro-2-propyl-phosphate-and-dechlorane-plus
#15
Mona L Jacobsen, Veerle L B Jaspers, Tomasz M Ciesielski, Bjørn M Jenssen, Mari E Løseth, Nathalie Briels, Igor Eulaers, Páll S Leifsson, Frank F Rigét, Pilar Gomez-Ramirez, Christian Sonne
Japanese quails (Coturnix japonica) were exposed in ovo to tris(1,3-dichloro-2-propyl) phosphate (TDCIPP; 500 ng/µl), Dechlorane Plus (DP; 500 ng/µl), or a 1:1 mixture of these two to investigate the effects on liver and thyroid gland morphology. Histological examination of 14-day-old quails showed that exposure to TDCIPP or the mixture induced hepatic sinusoidal dilatation. No marked effects were seen for DP alone. In addition, the mixture produced divergence of thyroid gland follicles and proliferation of follicular cells...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28692958/grift-a-device-for-quantifying-physiological-and-pathological-mirror-movements-in-children
#16
E Jaspers, K Klingels, C Simon-Martinez, H Feys, D G Woolley, N Wenderoth
Mirror movements (MM) typically occur during unilateral actions and manifest as involuntary muscle activity of the passive limb, which "mirror" voluntary actions executed by the contralateral homologous body part. They are a normal motor feature in young children and gradually disappear during the first decade of life. In children suffering from neurological disorders, e.g. due to an early brain lesion as in unilateral cerebral palsy, the amplitude and occurrence of MM has been proposed to yield relevant information for diagnosis and therapy...
July 5, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28692588/utilization-of-colonoscopy-and-colonoscopic-findings-among-individuals-aged-40-54-years-with-a-positive-family-history-of-colorectal-cancer-a-cross-sectional-study-in-general-practice
#17
Jasper Plath, Andrea Siebenhofer, Ulrike Haug, Insa Koné, Marlene Hechtner, Irina Blumenstein, Sylvia Schulz-Rothe, Ferdinand M Gerlach, Corina Guethlin
Guidelines recommend early colonoscopy for individuals with a positive family history of colorectal cancer (CRC), but little is known about the utilization of colonoscopy and the frequency of colorectal neoplasms among younger affected individuals in Germany. The aim of this study was to determine the utilization of colonoscopy and the frequency of colorectal neoplasms in this risk group. We conducted a cross-sectional study in a general practice setting. Patients aged 40-54 years with at least one first-degree relative with CRC were identified, counseled on their increased risk, and referred to colonoscopy if they decided to undergo this procedure...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28690076/patient-non-adherence-to-guideline-recommended-care-in-acute-low-back-pain
#18
Jasper D Bier, Steven J Kamper, Arianne P Verhagen, Christopher G Maher, Christopher M Williams
OBJECTIVE: To describe the magnitude of patient reported non-adherence with guideline-recommended care for acute low back pain. DESIGN: Secondary analysis of data from participants enrolled in the PACE trial, a randomised controlled trial evaluating the effectiveness of paracetamol for acute low back pain. PARTICIPANTS: Data from 1643 participants with acute low back pain. INTERVENTIONS: Guideline recommendend care including; reassurance, simple analgesia, and the advice to stay active and avoid bed rest...
July 6, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28689432/metabolite-profiling-in-early-clinical-drug-development-current-status-and-future-prospects
#19
Mike Ufer, Pierre-Eric Juif, Marie-Laure Boof, Clemens Muehlan, Jasper Dingemanse
No abstract text is available yet for this article.
July 10, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28688358/trace-element-concentrations-in-feathers-and-blood-of-northern-goshawk-accipiter-gentilis-nestlings-from-norway-and-spain
#20
Kevin J Dolan, Tomasz M Ciesielski, Syverin Lierhagen, Igor Eulaers, Torgeir Nygård, Trond V Johnsen, Pilar Gómez-Ramírez, Antonio J García-Fernández, Jan O Bustnes, Manuel E Ortiz-Santaliestra, Veerle L B Jaspers
Information on trace element pollution in the terrestrial environment and its biota is limited compared to the marine environment. In the present study, we collected body feathers and blood of 37 Northern goshawk (Accipiter gentilis) nestlings from Tromsø (northern Norway), Trondheim (central Norway), and Murcia (southeastern Spain) to study regional exposure, hypothesizing the potential health risks of metals and other trace elements. Blood and body feathers were analyzed by a high resolution inductively coupled plasma mass spectrometer (HR-ICP-MS) for aluminum (Al), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), cadmium (Cd), mercury (Hg) and lead (Pb)...
July 5, 2017: Ecotoxicology and Environmental Safety
keyword
keyword
30468
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"