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https://www.readbyqxmd.com/read/28926833/circulating-igf-i-igfbp-3-and-the-igf-i-igfbp-3-molar-ratio-concentration-and-height-outcome-in-prepubertal-short-children-on-rhgh-treatment-over-two-years-of-therapy
#1
María Gabriela Ballerini, Débora Braslavsky, Paula Alejandra Scaglia, Ana Keselman, María Eugenia Rodríguez, Alicia Martínez, Analía Verónica Freire, Horacio Mario Domené, Héctor Guillermo Jasper, Ignacio Bergadá, María Gabriela Ropelato
OBJECTIVE: To investigate the occurrence of abnormally elevated values of biomarkers of growth hormone (GH) action in short children on recombinant human GH (rhGH) therapy. METHODS: Sixty-three prepubertal short children were examined: 31 with GH deficiency (GHD), 25 small for gestational age (SGA), and 9 with Turner syndrome (TS). The main outcomes were the following: standard deviation score (SDS) values of IGF-I, IGFBP-3, and IGF-I/IGFBP-3 molar ratio before, at the 1st and at the 2nd year on rhGH and Δheight (Ht)-SDS to evaluate GH treatment efficacy (adequate 1st-year ΔHt SDS: >0...
September 19, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28924879/a-systematic-review-and-meta-analysis-of-timing-and-outcome-of-intestinal-failure-surgery-in-patients-with-enteric-fistula
#2
Fleur E E de Vries, Jasper J Atema, Oddeke van Ruler, Carolynne J Vaizey, Mireille J Serlie, Marja A Boermeester
BACKGROUND: The timing of intestinal failure (IF) surgery has changed. Most specialized centers now recommend postponing reconstructive surgery for enteric fistula and emphasize that abdominal sepsis has to be resolved and the patient's condition improved. Our aim was to study the outcome of postponed surgery, to identify risk factors for recurrence and mortality, and to define more precisely the optimal timing of reconstructive surgery. METHODS: PubMed, Embase, and the Cochrane Library were systematically reviewed on the outcomes of reconstructive IF surgery (fistula recurrence, mortality, morbidity, hernia recurrence, total closure, enteral autonomy)...
September 18, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28921767/expansion-of-cd4-phenotype-among-cd160-receptor-expressing-lymphocytes-in-murine-pregnancy
#3
Matyas Meggyes, Laszlo Szereday, Pal Jakso, Barbara Bogar, Agnes Bogdan, Jasper Nörenberg, Eva Miko, Aliz Barakonyi
PROBLEM: CD160, a cell surface co-receptor, is capable of up- or downregulating cell proliferation, cytotoxicity or cytokine production on lymphocytes. Our aim was to investigate CD160(+) lymphocytes in the periphery and at the maternal-foetal interface during murine pregnancy. METHOD OF STUDY: CD4(+) , CD8(+) and gamma/delta T-cell phenotype, TIM3 co-expression and cytotoxic activity of CD160(+) lymphocytes of pregnant BALB/c mice were analysed by flow cytometry...
September 16, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28915544/mobilisation-of-toxic-trace-elements-under-various-beach-nourishments
#4
Iris R Pit, Stefan C Dekker, Tobias J Kanters, Martin J Wassen, Jasper Griffioen
To enhance protection and maintain wide beaches for recreation, beaches are replenished with sand: so-called beach nourishments. We compared four sites: two traditional beach nourishments, a mega beach nourishment and a reference without beach nourishment. Two sites contain calcareous-rich sand, whereas the other two sites have calcareous-poor sand. We aimed to understand hydrogeochemical processes to indicate factors critical for the mobility of trace elements at nourishments. We therefore analysed the chemical characteristics of sediment and pore water to ascertain the main drivers that mobilise toxic trace elements...
September 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28914158/studying-positive-and-negative-direct-and-extended-contact-complementing-self-reports-with-social-network-analysis
#5
Ralf Wölfer, Eva Jaspers, Danielle Blaylock, Clarissa Wigoder, Joanne Hughes, Miles Hewstone
Traditionally, studies of intergroup contact have primarily relied on self-reports, which constitute a valid method for studying intergroup contact, but has limitations, especially if researchers are interested in negative or extended contact. In three studies, we apply social network analyses to generate alternative contact parameters. Studies 1 and 2 examine self-reported and network-based parameters of positive and negative contact using cross-sectional datasets ( N = 291, N = 258), indicating that both methods help explain intergroup relations...
July 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28913826/modeling-tolerance-development-for-the-effect-on-heart-rate-of-the-selective-s1p1-receptor-modulator-ponesimod
#6
Dominik Lott, Thorsten Lehr, Jasper Dingemanse, Andreas Krause
Ponesimod is a selective sphingosine-1-phosphate-1 (S1P1 ) receptor modulator currently under investigation for the treatment of multiple sclerosis. S1P receptor modulators reduce heart rate following treatment initiation. This effect disappears with repeated dosing, enabling development of innovative up-titration regimens to optimize patient safety. There are currently no published pharmacokinetic/pharmacodynamic models describing the heart rate reduction of S1P receptor modulators in humans. The model developed here provides quantification of this effect for ponesimod...
September 15, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28912128/aging-modifies-the-effect-of-cardiac-output-on-middle-cerebral-artery-blood-flow-velocity
#7
Anne-Sophie G T Bronzwaer, Jasper Verbree, Wim J Stok, Mat J A P Daemen, Mark A van Buchem, Matthias J P van Osch, Johannes J van Lieshout
An association between cerebral blood flow (CBF) and cardiac output (CO) has been established in young healthy subjects. As of yet it is unclear how this association evolves over the life span. To that purpose, we continuously recorded mean arterial pressure (MAP; finger plethysmography), CO (pulse contour; CO-trek), mean blood flow velocity in the middle cerebral artery (MCAV; transcranial Doppler ultrasonography), and end-tidal CO2 partial pressure (PetCO2) in healthy young (19-27 years), middle-aged (51-61 years), and elderly subjects (70-79 years)...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28910708/telomere-quantification-in-frontal-and-temporal-brain-tissue-of-patients-with-schizophrenia
#8
Hans C van Mierlo, Catharina G K Wichers, Yujie He, Marjolein A M Sneeboer, Timothy R D J Radstake, René S Kahn, Jasper C A Broen, Lot D de Witte
Recent imaging studies have suggested that accelerated aging occurs in schizophrenia. However, the exact cause of these findings is still unclear. In this study we measured telomere length, a marker for cell senescence, in gray and white matter brain tissue from the medial frontal gyrus (MFG) and superior temporal gyrus (STG) of 9 patients with schizophrenia and 11 controls. No alterations in telomere length were found in MFG gray and white matter and in STG gray matter. A significant reduction in telomere length was observed in STG white matter of patients with schizophrenia as compared to controls (fold change of -0...
September 7, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28903034/piwi-is-required-to-limit-exhaustion-of-aging-somatic-stem-cells
#9
Pedro Sousa-Victor, Arshad Ayyaz, Rippei Hayashi, Yanyan Qi, David T Madden, Victoria V Lunyak, Heinrich Jasper
Sophisticated mechanisms that preserve genome integrity are critical to ensure the maintenance of regenerative capacity while preventing transformation of somatic stem cells (SCs), yet little is known about mechanisms regulating genome maintenance in these cells. Here, we show that intestinal stem cells (ISCs) induce the Argonaute family protein Piwi in response to JAK/STAT signaling during acute proliferative episodes. Piwi function is critical to ensure heterochromatin maintenance, suppress retrotransposon activation, and prevent DNA damage in homeostasis and under regenerative pressure...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28898442/bayesian-estimation-of-multivariate-normal-mixtures-with-covariate-dependent-mixing-weights-with-an-application-in-antimicrobial-resistance-monitoring
#10
Stijn Jaspers, Arnošt Komárek, Marc Aerts
Bacteria with a reduced susceptibility against antimicrobials pose a major threat to public health. Therefore, large programs have been set up to collect minimum inhibition concentration (MIC) values. These values can be used to monitor the distribution of the nonsusceptible isolates in the general population. Data are collected within several countries and over a number of years. In addition, the sampled bacterial isolates were not tested for susceptibility against one antimicrobial, but rather against an entire range of substances...
September 12, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28892268/decoupling-the-effects-of-high-crystallinity-and-surface-area-on-the-photocatalytic-overall-water-splitting-over-%C3%AE-ga2o3-nanoparticles-by-chemical-vapor-synthesis
#11
Sasa Lukic, Jasper Menze, Philipp Weide, Wilma Busser, Markus Winterer, Martin Muhler
Chemical vapor synthesis (CVS) is a unique method to prepare well-defined photocatalyst materials with both large specific surface area and a high degree of crystallinity. The obtained β-Ga2O3 nanoparticles were optimized for photocatalysis by reductive photodeposition of the Rh/CrOx cocatalyst system. The influence of the degree of crystallinity and the specific surface area on photocatalytic aqueous methanol reforming and overall water splitting (OWS) was investigated by synthesizing β-Ga2O3 samples in the temperature range from 1000˚C to 1500˚C...
September 11, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28891792/pgam5-promotes-lasting-foxo-activation-after-developmental-mitochondrial-stress-and-extends-lifespan-in-drosophila
#12
Martin Borch Jensen, Yanyan Qi, Rebeccah Riley, Liya Rabkina, Heinrich Jasper
The mitochondrial unfolded protein response (UPR(mt)) has been associated with long lifespan across metazoans. In C. elegans, mild developmental mitochondrial stress activates UPR(mt) reporters and extends lifespan. We show that similar developmental stress is necessary and sufficient to extend Drosophila lifespan, and identify Phosphoglycerate Mutase 5 (PGAM5) as a mediator of this response. Developmental mitochondrial stress leads to activation of FoxO, via Apoptosis Signal-regulating Kinase 1 (ASK1) and Jun-N-terminal Kinase (JNK)...
September 11, 2017: ELife
https://www.readbyqxmd.com/read/28888287/the-optimism-trap-migrants-educational-choices-in-stratified-education-systems
#13
Jasper Dag Tjaden, Christian Hunkler
Immigrant children's ambitious educational choices have often been linked to their families' high level of optimism and motivation for upward mobility. However, previous research has mostly neglected alternative explanations such as information asymmetries or anticipated discrimination. Moreover, immigrant children's higher dropout rates at the higher secondary and university level suggest that low performing migrant students could have benefitted more from pursuing less ambitious tracks, especially in countries that offer viable vocational alternatives...
September 2017: Social Science Research
https://www.readbyqxmd.com/read/28880248/x-ray-free-electron-laser-determination-of-crystal-structures-of-dark-and-light-states-of-a-reversibly-photoswitching-fluorescent-protein-at-room-temperature
#14
Christopher D M Hutchison, Violeta Cordon-Preciado, Rhodri M L Morgan, Takanori Nakane, Josie Ferreira, Gabriel Dorlhiac, Alvaro Sanchez-Gonzalez, Allan S Johnson, Ann Fitzpatrick, Clyde Fare, Jon P Marangos, Chun Hong Yoon, Mark S Hunter, Daniel P DePonte, Sébastien Boutet, Shigeki Owada, Rie Tanaka, Kensuke Tono, So Iwata, Jasper J van Thor
The photochromic fluorescent protein Skylan-NS (Nonlinear Structured illumination variant mEos3.1H62L) is a reversibly photoswitchable fluorescent protein which has an unilluminated/ground state with an anionic and cis chromophore conformation and high fluorescence quantum yield. Photo-conversion with illumination at 515 nm generates a meta-stable intermediate with neutral trans-chromophore structure that has a 4 h lifetime. We present X-ray crystal structures of the cis (on) state at 1.9 Angstrom resolution and the trans (off) state at a limiting resolution of 1...
September 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28878725/the-logic-of-appearance-dennett-phenomenology-and-psychoanalysis
#15
Jasper Feyaerts, Stijn Vanheule
In the present essay, we aim to develop and contrast three different positions toward Sellars' distinction between the manifest and scientific images of man: Dennett's philosophical reconstruction of neurocognitive science, contemporary phenomenology and psychoanalysis. We will suggest that these respective traditions and the substantial differences between them can be understood in terms of a 'logic of appearance.' Related to this are differing ideas about the rights and limits of the first-person perspective, the relation between conscious experience and belief, and the issue of naturalization...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28873674/the-effect-of-algae-diets-skeletonema-costatum-and-rhodomonas-baltica-on-the-biochemical-composition-and-sensory-characteristics-of-pacific-cupped-oysters-crassostrea-gigas-during-land-based-refinement
#16
Jasper van Houcke, Isabel Medina, Hanne K Maehre, Josiane Cornet, Mireille Cardinal, Jozef Linssen, Joop Luten
Oyster refinement, a common practice in France, is aimed at increasing the weight of oyster tissue and influencing the taste properties of the refined oysters. Refinement usually takes place in land-based systems where the oysters are fed with relatively high concentrations of microalgae. In this study the impact of feeding Skeletonema costatum and Rhodomonas baltica on the biochemical composition and sensory characteristics of Pacific cupped oysters (Crassostrea gigas) from the Eastern Scheldt during land-based refinement was studied...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28873255/accelerated-4d-self-gated-mri-of-tibiofemoral-kinematics
#17
Valentina Mazzoli, Jasper Schoormans, Martijn Froeling, Andre M Sprengers, Bram F Coolen, Nico Verdonschot, Gustav J Strijkers, Aart J Nederveen
Anatomical (static) magnetic resonance imaging (MRI) is the most useful imaging technique for the evaluation and assessment of internal derangement of the knee, but does not provide dynamic information and does not allow the study of the interaction of the different tissues during motion. As knee pain is often only experienced during dynamic tasks, the ability to obtain four-dimensional (4D) images of the knee during motion could improve the diagnosis and provide a deeper understanding of the knee joint. In this work, we present a novel approach for dynamic, high-resolution, 4D imaging of the freely moving knee without the need for external triggering...
September 5, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28867648/tendon-injury-and-repair-a-perspective-on-the-basic-mechanisms-of-tendon-disease-and-future-clinical-therapy
#18
REVIEW
Jess G Snedeker, Jasper Foolen
Tendon is an intricately organized connective tissue that efficiently transfers muscle force to the bony skeleton. Its structure, function, and physiology reflect the extreme, repetitive mechanical stresses that tendon tissues bear. These mechanical demands also lie beneath high clinical rates of tendon disorders, and present daunting challenges for clinical treatment of these ailments. This article aims to provide perspective on the most urgent frontiers of tendon research and therapeutic development. We start by broadly introducing essential elements of current understanding about tendon structure, function, physiology, damage, and repair...
September 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28865300/technical-feasibility-of-personalized-articulating-knee-joint-distraction-for-treatment-of-tibiofemoral-osteoarthritis
#19
T Struik, J E N Jaspers, N J Besselink, P M van Roermund, S Plomp, M J Rudert, F P J G Lafeber, S C Mastbergen
BACKGROUND: Knee osteoarthritis is a highly prevalent degenerative joint disorder characterized by joint tissue damage and pain. Knee joint distraction has been introduced as a joint preserving surgical procedure to postpone knee arthroplasty. An often used standard externally fixation device for distraction poses a burden to patients due to the absence of joint flexion during the 6weeks treatment. Therefore, a personalized articulating distraction device was developed. The aim of this study was to test technical feasibility of this device...
August 12, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28863540/theoretical-investigation-of-intersystem-crossing-in-the-cyanonitrene-molecule-1-ncn-%C3%A2-3-ncn
#20
Mark Pfeifle, Yuri Georgievskii, Ahren W Jasper, Stephen J Klippenstein
The NCN diradical is an important intermediate of prompt nitric oxide formation in flames. The mechanism of intersystem crossing (ISC) in the NCN molecule formed via pyrolysis or photolysis of NCN3 is of relevance to the interpretation of experiments that utilize NCN3 as a precursor for laboratory studies of NCN kinetics. This mechanism has been investigated by means of multi-reference configuration interaction calculations. From the potential energy surfaces for NCN3 dissociation, it was inferred that both thermal and photo-chemical decomposition initially lead to NCN in its lowest singlet state, ã(1)Δg, with a possible contribution from the b̃(1)Σg(+) state at low photolysis wavelengths...
August 28, 2017: Journal of Chemical Physics
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