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Liam D Curless, Ewan R Clark, Jessica Cid, Alessandro Del Grosso, Michael J Ingleson
The addition of CO to [((R3N)BH2)2(μ-H)][B(C6F5)4] leads to formation of trimethylboroxine ((MeBO)3) and [(R3N)2BH2][B(C6F5)4]. When R = Et, [(Et3N)H2B(μ-O)B(CH3)NEt3][B(C6F5)4], is isolated and demonstrated to be an intermediate in the formation of (MeBO)3.
July 11, 2015: Chemical Communications: Chem Comm
Masaki Ito, Masumi Itazaki, Hiroshi Nakazawa
Selective B-O-Si bond formation was achieved in the reaction of bisboryloxide O(Bpin)2 (pin = (OCMe2)2)/boroxine (MeBO)3 system with tertiary silane R3SiH in the presence of stoichiometric water and a catalytic amount of [M](CO)5 ([M] = Mo(CO), W(CO), Fe) to give boryl silyl ethers. Moreover, this reaction can be applied to various hydrosilanes (disilyl compounds and secondary silanes) and hydrogermane. Some of the boryl silyl ethers thus formed were confirmed by X-ray analysis.
April 30, 2014: Journal of the American Chemical Society
M R El-Hadidy, A R El-Hadidy, A Bhaa, S A Asker, S A Mazroa
Moist Exposed Burn Ointment (MEBO(®)) is widely used topical agent applied on skin burn. This study investigated the effect of MEBO topical application on activation and proliferation of epidermal stem cells through the immunohistochemical localization of cytokeratin 19 (CK19) as a known marker expressed in epidermal stem cells. Biopsies from normal skin and burn wounds were taken from 21 patients with partial thickness burn 1, 4, 7, 14, 21, and 28 days after treatment with MEBO. Tissue sections were prepared for histological study and for CK19 immunohistochemical localization...
April 2014: Tissue & Cell
Qian-Li Tang, Shan-Shan Han, Jing Feng, Jia-Qi Di, Wen-Xi Qin, Jun Fu, Qiu-Yan Jiang
Cutaneous delayed wounds are a challenging clinical problem, and vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) exhibit key roles in wound healing. Moist exposed burn ointment (MEBO), a Chinese burn ointment with a USA patented formulation, has been reported to promote chronic ischemic and neurogenic ulcer healing in patients; however, the underlying mechanisms remain unclear. In the present study, MEBO significantly promoted the formation of granulation tissue in cutaneous excisional wounds, shortened the time of wound healing, and increased neovascularization and the number of fibroblasts...
April 2014: Molecular Medicine Reports
Edgar Corneille Ontsouka, Xiao Huang, Bruno Stieger, Christiane Albrecht
Cholesterol in milk is derived from the circulating blood through a complex transport process involving the mammary alveolar epithelium. Details of the mechanisms involved in this transfer are unclear. Apolipoprotein-AI (apoA-I) is an acceptor of cellular cholesterol effluxed by the ATP-binding cassette (ABC) transporter A1 (ABCA1). We aimed to 1) determine the binding characteristics of (125)I-apoA-I and (3)H-cholesterol to enriched plasma membrane vesicles (EPM) isolated from lactating and non-lactating bovine mammary glands (MG), 2) optimize the components of an in vitro model describing cellular (3)H-cholesterol efflux in primary bovine mammary epithelial cells (MeBo), and 3) assess the vectorial cholesterol transport in MeBo using Transwell(®) plates...
2013: PloS One
Huihui Liu, Shaohui Lin, Dan Xiao, Xiao Zheng, Yan Gu, Shanyu Guo
Resina Draconis (RD) is a type of dragon's blood resin obtained from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China). It has been used as a medicine since ancient times by many cultures. The ethanolic extract of Resina Draconis (RDEE) was evaluated for its wound-healing activity using excision and incision wound models in rats. Group I, the control group, was treated with ointment base. Group II, which served as a reference standard, was treated with moist exposed burn ointment (MEBO). Group III was treated with RDEE...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
Muammar A Y Nassar, Heba M Saad Eldien, Hanem S Abdel Tawab, Tahia H Saleem, Hossam M Omar, Ahmed Y Nassar, Mahmoud Rezk Abdelwahed Hussein
BACKGROUND: Thermal tissue injury is partly mediated by reactive oxygen metabolites. Oxygen free radicals are contributory to local tissue damage following thermal injury and accordingly an interventional therapy using antioxidants may be beneficial. Copper nicotinate complex can scavenge reactive oxygen species (i.e., has antioxidant activity). OBJECTIVES: To examine time-related morphological and biochemical changes following skin thermal injury and their modulation by copper nicotinate complex...
October 2012: Ultrastructural Pathology
Vilelmine J Carayanni, Evangelia G Tsati, Georgia C H Spyropoulou, Fotini N Antonopoulou, John D Ioannovich
BACKGROUND: The local treatment of burn wounds has long been a subject of debate. The objective of this study was to compare the cost and the effectiveness of Moist Exposed Burn Ointment -MEBO versus a combination of povidone iodine plus bepanthenol cream for partial thickness burns. METHODS: The study was carried out in the Burn Center of a state hospital in Athens, Greece. 211 patients needing conservative therapy were prospectively selected according to the depth of the burn wound...
2011: BMC Complementary and Alternative Medicine
Amr Mabrouk, Nahed Samir Boughdadi, Hesham A Helal, Basim M Zaki, Ashraf Maher
INTRODUCTION: The face is the central point of the physical features; it transmits expressions and emotions, communicates feelings and allows for individual identity. Facial burns are very common and are devastating to the affected patient and results into numerous physical, emotional and psychosocial sequels. Partial thickness facial burns are very common especially among children. This study compares the effect of standard moist open technique management and a moist closed technique for partial thickness burns of the face...
May 2012: Burns: Journal of the International Society for Burn Injuries
A Hindy
Facial burns vary from relatively minor insults to severe debilitating injuries. Sustaining a burn injury is often a psychological trauma for the victim and is especially menacing when the face and neck are involved. This study was carried out on 60 patients with superficial dermal burns to the face admitted to the Burn Unit of Tanta University Hospital, Egypt, from September 2007 to July 2008. The patients were allocated randomly to one of three groups, each of which was treated with one of the following: sodium carboxymethyl-cellulose silver (Aquacel Ag®), MEBO® (moist exposed burn ointment), or saline-soaked dressing...
September 30, 2009: Annals of Burns and Fire Disasters
P I Jewo, I O Fadeyibi, O S Babalola, L C Saalu, A S Benebo, M C Izegbu, O A Ashiru
Burns expose the deeper tissues of the skin or body to invasive microbes. Topical preparations for treating burn wounds, to be useful, should ideally have antibiotic power and promote healing. Silver compounds have been the mainstay of topical burn treatment for decades. However, most chemical substances retard wound healing. Several natural agents such as honey and moist exposed burn ointment (MEBO) are believed to protect wounds from infection and promote healing without causing any of the adverse effects of purified chemicals...
June 30, 2009: Annals of Burns and Fire Disasters
M Al-Meshaan, M Abdul Hamid, T Quider, A Al-Sairafi, R Dham
Objectives. Fournier's gangrene (FG), though rare, is a life-threatening extensive fulminant infection of the genitals, perineum, or abdominal wall caused by a mixture of aerobic and anaerobic micro-organisms. Early and aggressive surgical debridement of the necrotic tissue and complete antibiotic coverage are the gold standards in treating FG. The purpose of our study was to assess the role of MEBO (moist exposed burn ointment) in topical treatment of the wound secondary to surgical debridement. Methods. Eleven patients (age range, 40-75 yr; mean, 55 yr) were admitted to the clinical facilities of the Department of Urology at Al Sabah Hospital, Kuwait, suffering from Fournier's gangrene, in the 31-month period between January 2004 and July 2006...
March 31, 2008: Annals of Burns and Fire Disasters
A M Allam, W Mostafa, E Zayed, J El-Gamaly
Hand burns predominantly affect young adults, and therefore have serious social and financial implications. In the present work, 106 patients with less than 25% body surface area burns and acute partial-thickness burned hands were managed using polyethylene bags and 1% local silver sulphadiazine (SSD) cream or moist exposed burn ointment (MEBO). Females made up 61.3% of the cases and flame burn was the majority cause (54.7%). There were no significant differences between the two groups regarding either the analgesic effect after local ointment application or hand movement inside the polyethylene bag...
September 30, 2007: Annals of Burns and Fire Disasters
Y Wang, C R Baumrucker
Two bovine mammary cell types (BME-UV1 and MeBo cells) were used to evaluate the effect of natural retinoids, retinoid analogs, and bovine lactoferrin (bLf) on cell viability in vitro. Experiments with Alamar Blue showed a linear relationship between fluorescence and cell viability index. The BME-UV1 cells exhibited twice the metabolic activity but required half the doubling time of the MeBo cells. The BME-UV1 cells were very sensitive to all-trans retinoic acid (atRA) inhibition of cell viability (P<0.05) and exhibited a dose-dependent inhibition with 9-cisRA (9cRA; P<0...
July 2010: Domestic Animal Endocrinology
Hyun-Sook Son, Woo Yong Lee, Won-Suk Lee, Seong Hyeon Yun, Ho-Kyung Chun
PURPOSE: Physicians and oncology nurses must continue to update their knowledge on treatment and treatment-related side effects, while searching for effective methods to prevent or manage side effects. The objective of our study was to describe the incidence and response to treatment of the hand-foot syndrome (HFS) and the compliance with treatment of patients with stage IIB, IIIA, IIIB, and IIIC colon cancer that were treated with capecitabine alone as adjuvant therapy. MATERIALS AND METHODS: Between September 2005 and September 2006, 84 patients fulfilled the inclusion criteria and were included in this retrospective analysis of prospectively collected data...
December 31, 2009: Yonsei Medical Journal
Cynthia G El Kahi, Bishara S Atiyeh, Inaya Abdallah Hajj Hussein, Rosalyne Jurjus, Saad A Dibo, Alice Jurjus, Abdo Jurjus
The myofibroblast, a major component of granulation tissue, is a key cell during wound healing, tissue repair and connective tissue remodelling. Persistence of myofibroblasts within a fibrotic lesion leads to excessive scarring impairing function and aesthetics. Various wound-healing cytokines can be modulated by topical application of active agents to promote optimal wound healing and improve scar quality. Thus, the myofibroblast may represent an important target for wound-healing modulation to improve the evolution of conditions such as hypertrophic scars...
June 2009: International Wound Journal
T Hirsch, W Ashkar, O Schumacher, L Steinstraesser, G Ingianni, C C Cedidi
OBJECTIVE: Wound healing in burn wounds presents a challenge in healthcare, and there is still a lack of alternatives in topical burn wound treatments. - The purpose of this study was to evaluate the efficacy of a new therapeutic ointment (MEBO) in the treatment of partial thickness burns. METHODS: 40 patients received either topical treatment with Moist Exposed Burn Ointment (MEBO) or standard Flammazine treatment. All patients suffered from partial-thickness burn injuries (< 20% TBSA)...
November 24, 2008: European Journal of Medical Research
Dimosthenis Tsoutsos, Despoina Kakagia, Konstantinos Tamparopoulos
Snail extracts have been increasingly used in numerous dermatologic conditions and recent literature attributes healing, soothing and anti-aging properties to them. This study evaluates the efficacy of Helix aspersa extract in an open wound management protocol for deep partial thickness (PT) facial burns and compares it to moist exposure burn ointment(MEBO). A total of 27 adult patients with deep partial thickness facial burns (group A) were treated by application of a snail extract cream twice daily for a maximum period of 14 days or until full epithelialization...
2009: Journal of Dermatological Treatment
Lei Zhang, Yongli Huo, Jianhua Wang, Hua Li, Jianfeng Xing, Zhigan Sun, Chi Feng, Yinghua Liu
OBJECTIVE: To study a new method of alveolar cleft bone graft repair. METHODS: From April 2005 to August 2006, 26 cases (30 sides) of alveolar cleft were treated with trabecular substance of self-ilium combined with the decalcified dentinal matrix of human (DDM). There were 16 males and 10 females, aged 6-12 years. Unilateral alveolar cleft was involved in 22 cases, bilateral alveolar cleft in 4 cases. All cases were accompanied by nasal wing collapse, 5 by deciduous tooth retention, 3 by malposed teeth and 1 by tooth deformity...
March 2008: Chinese Journal of Reparative and Reconstructive Surgery
Ky Young Cho, Soo Jung Lee, Jin Sik Burm, Eun Ae Park
Extravasation injuries in the neonatal intensive care unit are not rare during parenteral hyperalimentation. There have been many different methods of management. We report five premature infants with wounds of hyperalimentation fluid extravasation managed by the antibacterial ointment (Terramycin ophthalmic ointment and sesame oil and a antiinflammatory herbal mixture (MEBO).) The mean gestational age of patients was 31(+2) weeks (range, 28(+4) to 35(+6) weeks), and the mean weight at extravasation was 1,930 g (range, 1,140 to 2,680 g)...
June 2007: Journal of Korean Medical Science
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