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Hua-Wei Ouyang, Gao-Feng Li, Ying Lei, Michael H Gold, Jun Tan
INTRODUCTION: The objective was to investigate the clinical effect of an adjustable pulse width Pulsed Dye Laser (PDL) vs an adjustable pulse width PDL combined with fractional CO2 laser in treating immature red hypertrophic scars. METHODS: Fifty-six patients (56 sites)were randomly divided into a treatment group and control group. The control group was treated with the 595 nm PDL at a fluence of 7-15J/cm2 and pulse widths of 1.5-3 ms, 7 mm spot size. The treatment group was treated with a fractional CO2 laser (UltraPulse CO2 : Deep FX, Energy: 30~50 mJ, Frequency: 300 Hz, Density 5%, Scan Shape, and Spot Size were decided by shape and area of scar) after utilizing the 595 nm adjustable pulse width PDL (Fluence: 7-15J/cm2 , Pulse widths: 1...
February 2018: Journal of Cosmetic Dermatology
Wei Li, Yubo Ma, Qi Yang, Yu Pan, Qinggang Meng
BACKGROUND: Pressure ulcers often seriously affect the quality of life of patients. Moist Exposed Burn Ointment (MEBO) has been developed to treat patients with pressure ulcers. The present study aimed to evaluate the efficacy and safety of MEBO in the treatment of pressure ulcers in Chinese patients. METHODS: Seventy-two patients with pressure ulcers were randomly assigned to 2 groups who received a placebo or MEBO for 2 months. The primary outcomes included the wound surface area (WSA) and pressure ulcer scale for healing (PUSH) tool...
July 2017: Medicine (Baltimore)
Hua-Liang Li, Yi-Tao Deng, Zi-Ran Zhang, Qi-Rui Fu, Ya-Hui Zheng, Xing-Mei Cao, Jing Nie, Li-Wen Fu, Li-Ping Chen, You-Xiong Xiong, Dong-Yan Shen, Qing-Xi Chen
BACKGROUND: Crocodile oil and its products are used as ointments for burns and scalds in traditional medicines. A new ointment formulation - crocodile oil burn ointment (COBO) was developed to provide more efficient wound healing activity. The purpose of the study was to evaluate the burn healing efficacy of this new formulation by employing deep second-degree burns in a Wistar rat model. The analgesic and anti-inflammatory activities of COBO were also studied to provide some evidences for its further use...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
Sadanandan Rajapriya, Arumugam Geetha, Kavasseri Ganesan Kripa
The ever-increasing problem of pancreatitis due to alcohol abuse demands evaluation of novel drugs of plant origin. This study explores the therapeutic effects of the methanolic extract of Brassica oleraceae (MEBO) on ethanol and cerulein induced pancreatitis in rats. The MEBO was subjected to GC-MS and HPLC analysis. Male albino Wistar rats were divided into various groups, fed with alcohol (36% of total calories for 5 weeks) and cerulein (20 μg/kg b.wt i.p, weekly thrice for last three weeks) with or without MEBO (40 mg/kg b...
September 2017: Natural Product Research
Liam D Curless, Ewan R Clark, Jessica Cid, Alessandro Del Grosso, Michael J Ingleson
The addition of CO to [((R3N)BH2)2(μ-H)][B(C6F5)4] leads to formation of trimethylboroxine ((MeBO)3) and [(R3N)2BH2][B(C6F5)4]. When R = Et, [(Et3N)H2B(μ-O)B(CH3)NEt3][B(C6F5)4], is isolated and demonstrated to be an intermediate in the formation of (MeBO)3.
July 11, 2015: Chemical Communications: Chem Comm
Masaki Ito, Masumi Itazaki, Hiroshi Nakazawa
Selective B-O-Si bond formation was achieved in the reaction of bisboryloxide O(Bpin)2 (pin = (OCMe2)2)/boroxine (MeBO)3 system with tertiary silane R3SiH in the presence of stoichiometric water and a catalytic amount of [M](CO)5 ([M] = Mo(CO), W(CO), Fe) to give boryl silyl ethers. Moreover, this reaction can be applied to various hydrosilanes (disilyl compounds and secondary silanes) and hydrogermane. Some of the boryl silyl ethers thus formed were confirmed by X-ray analysis.
April 30, 2014: Journal of the American Chemical Society
M R El-Hadidy, A R El-Hadidy, A Bhaa, S A Asker, S A Mazroa
Moist Exposed Burn Ointment (MEBO(®)) is widely used topical agent applied on skin burn. This study investigated the effect of MEBO topical application on activation and proliferation of epidermal stem cells through the immunohistochemical localization of cytokeratin 19 (CK19) as a known marker expressed in epidermal stem cells. Biopsies from normal skin and burn wounds were taken from 21 patients with partial thickness burn 1, 4, 7, 14, 21, and 28 days after treatment with MEBO. Tissue sections were prepared for histological study and for CK19 immunohistochemical localization...
April 2014: Tissue & Cell
Qian-Li Tang, Shan-Shan Han, Jing Feng, Jia-Qi Di, Wen-Xi Qin, Jun Fu, Qiu-Yan Jiang
Cutaneous delayed wounds are a challenging clinical problem, and vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) exhibit key roles in wound healing. Moist exposed burn ointment (MEBO), a Chinese burn ointment with a USA patented formulation, has been reported to promote chronic ischemic and neurogenic ulcer healing in patients; however, the underlying mechanisms remain unclear. In the present study, MEBO significantly promoted the formation of granulation tissue in cutaneous excisional wounds, shortened the time of wound healing, and increased neovascularization and the number of fibroblasts...
April 2014: Molecular Medicine Reports
Edgar Corneille Ontsouka, Xiao Huang, Bruno Stieger, Christiane Albrecht
Cholesterol in milk is derived from the circulating blood through a complex transport process involving the mammary alveolar epithelium. Details of the mechanisms involved in this transfer are unclear. Apolipoprotein-AI (apoA-I) is an acceptor of cellular cholesterol effluxed by the ATP-binding cassette (ABC) transporter A1 (ABCA1). We aimed to 1) determine the binding characteristics of (125)I-apoA-I and (3)H-cholesterol to enriched plasma membrane vesicles (EPM) isolated from lactating and non-lactating bovine mammary glands (MG), 2) optimize the components of an in vitro model describing cellular (3)H-cholesterol efflux in primary bovine mammary epithelial cells (MeBo), and 3) assess the vectorial cholesterol transport in MeBo using Transwell(®) plates...
2013: PloS One
Huihui Liu, Shaohui Lin, Dan Xiao, Xiao Zheng, Yan Gu, Shanyu Guo
Resina Draconis (RD) is a type of dragon's blood resin obtained from Dracaena cochinchinensis (Lour.) S.C. Chen (Yunnan, China). It has been used as a medicine since ancient times by many cultures. The ethanolic extract of Resina Draconis (RDEE) was evaluated for its wound-healing activity using excision and incision wound models in rats. Group I, the control group, was treated with ointment base. Group II, which served as a reference standard, was treated with moist exposed burn ointment (MEBO). Group III was treated with RDEE...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
Muammar A Y Nassar, Heba M Saad Eldien, Hanem S Abdel Tawab, Tahia H Saleem, Hossam M Omar, Ahmed Y Nassar, Mahmoud Rezk Abdelwahed Hussein
BACKGROUND: Thermal tissue injury is partly mediated by reactive oxygen metabolites. Oxygen free radicals are contributory to local tissue damage following thermal injury and accordingly an interventional therapy using antioxidants may be beneficial. Copper nicotinate complex can scavenge reactive oxygen species (i.e., has antioxidant activity). OBJECTIVES: To examine time-related morphological and biochemical changes following skin thermal injury and their modulation by copper nicotinate complex...
October 2012: Ultrastructural Pathology
Vilelmine J Carayanni, Evangelia G Tsati, Georgia C H Spyropoulou, Fotini N Antonopoulou, John D Ioannovich
BACKGROUND: The local treatment of burn wounds has long been a subject of debate. The objective of this study was to compare the cost and the effectiveness of Moist Exposed Burn Ointment -MEBO versus a combination of povidone iodine plus bepanthenol cream for partial thickness burns. METHODS: The study was carried out in the Burn Center of a state hospital in Athens, Greece. 211 patients needing conservative therapy were prospectively selected according to the depth of the burn wound...
2011: BMC Complementary and Alternative Medicine
Amr Mabrouk, Nahed Samir Boughdadi, Hesham A Helal, Basim M Zaki, Ashraf Maher
INTRODUCTION: The face is the central point of the physical features; it transmits expressions and emotions, communicates feelings and allows for individual identity. Facial burns are very common and are devastating to the affected patient and results into numerous physical, emotional and psychosocial sequels. Partial thickness facial burns are very common especially among children. This study compares the effect of standard moist open technique management and a moist closed technique for partial thickness burns of the face...
May 2012: Burns: Journal of the International Society for Burn Injuries
A Hindy
Facial burns vary from relatively minor insults to severe debilitating injuries. Sustaining a burn injury is often a psychological trauma for the victim and is especially menacing when the face and neck are involved. This study was carried out on 60 patients with superficial dermal burns to the face admitted to the Burn Unit of Tanta University Hospital, Egypt, from September 2007 to July 2008. The patients were allocated randomly to one of three groups, each of which was treated with one of the following: sodium carboxymethyl-cellulose silver (Aquacel Ag®), MEBO® (moist exposed burn ointment), or saline-soaked dressing...
September 30, 2009: Annals of Burns and Fire Disasters
P I Jewo, I O Fadeyibi, O S Babalola, L C Saalu, A S Benebo, M C Izegbu, O A Ashiru
Burns expose the deeper tissues of the skin or body to invasive microbes. Topical preparations for treating burn wounds, to be useful, should ideally have antibiotic power and promote healing. Silver compounds have been the mainstay of topical burn treatment for decades. However, most chemical substances retard wound healing. Several natural agents such as honey and moist exposed burn ointment (MEBO) are believed to protect wounds from infection and promote healing without causing any of the adverse effects of purified chemicals...
June 30, 2009: Annals of Burns and Fire Disasters
M Al-Meshaan, M Abdul Hamid, T Quider, A Al-Sairafi, R Dham
Objectives. Fournier's gangrene (FG), though rare, is a life-threatening extensive fulminant infection of the genitals, perineum, or abdominal wall caused by a mixture of aerobic and anaerobic micro-organisms. Early and aggressive surgical debridement of the necrotic tissue and complete antibiotic coverage are the gold standards in treating FG. The purpose of our study was to assess the role of MEBO (moist exposed burn ointment) in topical treatment of the wound secondary to surgical debridement. Methods. Eleven patients (age range, 40-75 yr; mean, 55 yr) were admitted to the clinical facilities of the Department of Urology at Al Sabah Hospital, Kuwait, suffering from Fournier's gangrene, in the 31-month period between January 2004 and July 2006...
March 31, 2008: Annals of Burns and Fire Disasters
A M Allam, W Mostafa, E Zayed, J El-Gamaly
Hand burns predominantly affect young adults, and therefore have serious social and financial implications. In the present work, 106 patients with less than 25% body surface area burns and acute partial-thickness burned hands were managed using polyethylene bags and 1% local silver sulphadiazine (SSD) cream or moist exposed burn ointment (MEBO). Females made up 61.3% of the cases and flame burn was the majority cause (54.7%). There were no significant differences between the two groups regarding either the analgesic effect after local ointment application or hand movement inside the polyethylene bag...
September 30, 2007: Annals of Burns and Fire Disasters
Y Wang, C R Baumrucker
Two bovine mammary cell types (BME-UV1 and MeBo cells) were used to evaluate the effect of natural retinoids, retinoid analogs, and bovine lactoferrin (bLf) on cell viability in vitro. Experiments with Alamar Blue showed a linear relationship between fluorescence and cell viability index. The BME-UV1 cells exhibited twice the metabolic activity but required half the doubling time of the MeBo cells. The BME-UV1 cells were very sensitive to all-trans retinoic acid (atRA) inhibition of cell viability (P<0.05) and exhibited a dose-dependent inhibition with 9-cisRA (9cRA; P<0...
July 2010: Domestic Animal Endocrinology
Hyun-Sook Son, Woo Yong Lee, Won-Suk Lee, Seong Hyeon Yun, Ho-Kyung Chun
PURPOSE: Physicians and oncology nurses must continue to update their knowledge on treatment and treatment-related side effects, while searching for effective methods to prevent or manage side effects. The objective of our study was to describe the incidence and response to treatment of the hand-foot syndrome (HFS) and the compliance with treatment of patients with stage IIB, IIIA, IIIB, and IIIC colon cancer that were treated with capecitabine alone as adjuvant therapy. MATERIALS AND METHODS: Between September 2005 and September 2006, 84 patients fulfilled the inclusion criteria and were included in this retrospective analysis of prospectively collected data...
December 31, 2009: Yonsei Medical Journal
Cynthia G El Kahi, Bishara S Atiyeh, Inaya Abdallah Hajj Hussein, Rosalyne Jurjus, Saad A Dibo, Alice Jurjus, Abdo Jurjus
The myofibroblast, a major component of granulation tissue, is a key cell during wound healing, tissue repair and connective tissue remodelling. Persistence of myofibroblasts within a fibrotic lesion leads to excessive scarring impairing function and aesthetics. Various wound-healing cytokines can be modulated by topical application of active agents to promote optimal wound healing and improve scar quality. Thus, the myofibroblast may represent an important target for wound-healing modulation to improve the evolution of conditions such as hypertrophic scars...
June 2009: International Wound Journal
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