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https://www.readbyqxmd.com/read/28525380/comparison-among-fertility-sparing-therapies-for-well-differentiate-early-stage-endometrial-carcinoma-and-complex-atypical-hyperplasia
#1
REVIEW
Qing Zhang, Gonghua Qi, Margaux J Kanis, Ruifen Dong, Baoxia Cui, Xingsheng Yang, Beihua Kong
OBJECTIVE: To compare fertility-sparing therapies including oral progestogens, hysteroscopic resection (HR), and the levonorgestrel- releasing intrauterine system (LNG-IUS) in achieving disease regression, recurrence and live birth rate in well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia(CAH). STUDY DESIGN: This was a meta-analysis of previous studies focus on the fertility-sparing therapy for well differentiate early-stage endometrial carcinoma (eEC) and complex atypical hyperplasia (CAH)...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28516379/panobinostat-enhances-growth-suppressive-effects-of-progestin-on-endometrial-carcinoma-by-increasing-progesterone-receptor-and-mitogen-inducible-gene-6
#2
Hirofumi Ando, Tsutomu Miyamoto, Hiroyasu Kashima, Shotaro Higuchi, Koichi Ida, David Hamisi Mvunta, Tanri Shiozawa
Although progestin has been used to treat endometrial hyperplasia and endometrial carcinoma (EC), its therapeutic efficacy is limited. In order to improve this, the underlining mechanisms of the effects of progestin need to be elucidated in more detail. In the present study, we examined the involvement of mitogen-inducible gene-6 (MIG6), a negative regulator of the EGF receptor, in the progestin-mediated growth suppression of endometrial epithelia. The immunohistochemical expression of MIG6 was elevated in the early to mid-secretory phases of normal endometrium and also with endometrial hyperplasia after medroxyprogesterone acetate (MPA) therapy...
May 17, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28511462/story-of-a-giant-endometrial-polyp-in-asymptomatic-postmenopausal-female
#3
Jahnavi Meena, Rahul Manchanda, Sudhir Kulkarni, Nirmal Bhargava, Priyanka Mahawar
Endometrial polyps are localized overgrowth of endometrial glands and stoma through the uterine cavity. They are associated with postmenopausal bleeding, infertility and menorrhagia and are affected by unbalanced oestrogen therapy or increased frequency of tamoxifen exposure. We report a case of giant endometrial polyp in postmenopausal female without vaginal bleeding and hormone or drug use. A 65-year-old, postmenopausal female P3L2 with hypertension and Diabetes Mellitus (DM) came for routine health check-up...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509323/triple-negative-endometrial-cancer
#4
Michał Bulsa, Elżbieta Urasińska
Endometrial cancer (EC) is the most common malignancy of the female genital tract in the developed countries. In Poland, EC incidence increased from 3.496 to 5.251 between 2000 and 2011, with 5.251 new cases were diagnosed in 2011 alone, and this upward trend is expected to continue. There are two types of endometrial cancer: estrogen- related type I (approximately 80% of the cases) and unrelated to estrogen type II. Type I includes adenocarcinomas which grow slowly, have better prognosis, superficially infiltrate the myometrium, originate from endometrial hyperplasia without atypia, and occur before and after menopause...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28499530/recognition-and-therapeutic-options-for-malignancy-of-the-cervix-and%C3%A2-uterus
#5
REVIEW
Elizabeth R Burton, Joel I Sorosky
An update on the current epidemiology and a review of the risk factors of cervical and endometrial cancers are discussed. Cervical cancer prevention with a focus on human papillomavirus vaccination and cervical cancer screening is reviewed, emphasizing the new focus of less frequent intervention in an effort to maintain high rates of early detection of disease while decreasing unnecessary and anxiety-provoking colposcopies, biopsies, and excisional procedures. The replacement of traditional endometrial hyperplasia terminology with more relevant clinical categories, with an emphasis on the introduction of endometrial intraepithelial neoplasia, is presented...
June 2017: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/28486237/evaluating-the-age-cutoff-criterion-for-reporting-benign-appearing-endometrial-cells-in-routine-pap-tests-an-8-year-retrospective-review
#6
Zakaria Grada, Cherie Paquette, Claire M Eklund, Cunxian Zhang, C James Sung, Margaret Steinhoff, M Ruhul Quddus
OBJECTIVE: The 2014 Bethesda System recommends that benign-appearing endometrial cells (BECs) in routine Pap tests should be reported in patients aged ≥45 years. This is a change from previous guidelines to report BECs in women ≥40 years of age. BECs are reported to have 1% chance of endometrial lesion on follow-up. This study tests whether the new threshold may increase the specificity of the test for the detection of clinically significant endometrial lesions. STUDY DESIGN: After institutional review board approval, 1,177 BECs, reported during an 8-year study period in patients aged ≥40 years, were retrieved from 672,000 routine ThinPrep Pap tests...
May 10, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28483662/the-management-of-polyps-in-female-reproductive-organs
#7
REVIEW
Vasilios Tanos, Kelsey Elizabeth Berry, Jaana Seikkula, Elissa Abi Raad, Andreas Stavroulis, Zaki Sleiman, Rudi Campo, Stephan Gordts
Polyps of the lower reproductive tract are found in 7.8-50% of women. It has been hypothesized that cytogenetic modifications on chromosomes 6, 7 and 12 as well as epigenetic factors involving enzyme and metabolic activities may cause polyps to develop. Cervical polyps found in 2-5% of cases are of low clinical significance and can cause, although rarely, post coital bleedings. Cervical polyps grow during pregnancy and mucorrhoea. Trans vaginal ultrasound (TVU) provides an excellent diagnostic technique to diagnose the size and the anatomic location of endometrial polyps (EPs)...
May 5, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28482329/endometrial-changes-during-ulipristal-acetate-use-a-systematic-review
#8
REVIEW
Inge De Milliano, Dominique Van Hattum, Johannes C F Ket, Judith A F Huirne, Wouter J K Hehenkamp
Ulipristal acetate is increasingly used for several clinical indications, like emergency contraception and pre-treatment of uterine fibroids. It has mixed progesterone agonist and antagonist effects in the myometrium and endometrium. Due to its progesterone antagonistic effect, an unopposed estrogen effect could occur which could cause (pre-)malignant lesions in the endometrium. Several studies have been performed to evaluate this possible increased risk for endometrial malignancies when using ulipristal acetate...
April 28, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28476524/angioedema-attacks-related-to-endometrial-hyperplasia-in-a-case-of-estrogen-dependent-factor-xii-hereditary-angioedema
#9
Alicia Prieto-García, Dasha Roa Medellín, Maria Luisa Baeza
No abstract text is available yet for this article.
May 2, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28469526/a-case-report-ovarian-sertoli-leydig-cell-tumor-with-hyperestrogenism-and-endometrial-hyperplasia-in-a-postmenopausal-woman
#10
Yoko Tsuzuki, Iwaho Kikuchi, Michio Nojima, Koyo Yoshida, Akane Hashizume, Shigeki Tomita
The patient was a 66-year-old woman, G2P2. The patient presented a chief complaint of irregular postmenopausal bleeding 1 month ago. A transvaginal ultrasonography showed that bilateral ovaries were not enlarged and uterine endometrium was thickened, measuring at 9 mm. As a result of endometrial curettage, the simple endometrial hyperplasia was revealed. A blood examination showed an elevated estradiol level of 67 pg/mL, an elevated level of testosterone 0.64 ng/mL, and a slightly suppressed follicle-stimulating hormone (FSH) level of 34...
2017: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/28461830/histopathological-immunohistochemical-and-therapeutical-assessment-of-premalignant-endometrial-lesions-in-a-hospital-based-series-of-cases
#11
Georgescu Tiberiu Augustin, Cirstoiu Monica, Costache Mariana, Lazaroiu Anca, Dumitru Adrian, Sajin Maria
INTRODUCTION: Endometrial hyperplasia represents a diversified set of disorders which has challenged pathologists for decades. Due to its high likelihood of progression to carcinoma, endometrial intraepithelial neoplasia (EIN) demands prompt and specialized intervention. MATERIALS AND METHODS: This 15-month (September 2014 - November 2015) retrospective analysis involved 258 cases of female patients with atypical and non-atypical endometrial hyperplasia investigated and treated at the University Emergency Hospital in Bucharest, Romania...
June 2016: Mædica
https://www.readbyqxmd.com/read/28454369/overexpression-of-erythropoietin-producing-hepatocyte-receptor-b4-and-ephrin-b2-is-associated-with-estrogen-receptor-expression-in-endometrial-adenocarcinoma
#12
Ling-Dan Dong, Xiang-Lin Cheng, Long Zhou, Qing Huang, Jun-Chuan Li, Cun-Jian Yi
Endometrial adenocarcinoma (EC) is one of the most frequently diagnosed types of endometrial cancer and is typically a consequence of continuous estrogen receptor stimulation. Erythropoietin-producing hepatocyte receptor B4 (EphB4) and its ligand ephrin-B2 have been reported to be overexpressed in EC cells; however, the function in EC remains unclear. The present study aimed to elucidate the role of EphB4 and ephrin-B2 in EC. The protein expression pattern of EphB4 and ephrin-B2 was analyzed through immunohistochemistry and western blot analysis in endometrium with adenomyosis or simple endometrial hyperplasia, atypical endometrial hyperplasia, double-positive estrogen receptor (ER)/progesterone receptor (PR) EC and double-negative ER/PR EC...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28441840/-atypical-polypoid-adenomyoma-of-the-uterus-a-clinicopathological-review-of-27-cases
#13
T J Bai, D M Bao, Y Li, Y Wang, H Cui, H L Zhu
Objective: To investigate the clinical and pathological characteristics of atypical polypoid adenomyoma (APA) for improvement of the diagnosis, different diagnosis and treatment of the disease. Methods: The clinical data, pathological characteristics, and the follow-up information were retrospectively analyzed in 27 cases of APA admitted in Peking Univeristy People's Hospital from 2007 to 2016. Results: The median age was 42.6 years old (range 25-60 years old). Fifteen patients were nullipara, 2 patients were postmenopausal...
April 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28440476/exploration-of-mir-1202-and-mir-196a-in-human-endometrial-cancer-based-on-high-throughout-gene-screening-analysis
#14
Hong Chen, Yujuan Fan, Wensheng Xu, Junying Chen, Yugang Meng, Di Fang, Jingran Wang
Altered microRNA (miRNA) expression has been reported to participate in the pathogenesis of several human diseases, and particularly cancer. The present study examined the involvement of various miRNAs in the pathophysiology of endometrial cancer (EC) and atypical endometrial hyperplasia (AEH). We performed a high-throughput analysis of the miRNAs (miRNA microarray) found in samples of endometrial tissue obtained from 45 patients; among whom, 15 patients were diagnosed with EC, 15 patients were diagnosed with AEH, and the remainder were healthy donors...
April 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28439599/agreement-of-histopathological-findings-of-uterine-curettage-and-hysterectomy-specimens-in-women-with-abnormal-uterine-bleeding
#15
Sanam Moradan, Raheb Ghorbani, Azita Lotfi
To examined the diagnostic value of  dilatation and curettage (D and C) in patients with abnormal uterine bleeding (AUB) by conducting a histopathological examination of endometrial tissues by D and C and hysterectomy. Methods: In this retrospective study, the medical records of 163 women who had been hospitalized  in the Obstetrics and Gynecology Ward, Amir-al-Momenin Hospital, Semnan, Iran between 2010 and 2015 for diagnostic curettage due to  AUB and who had undergone hysterectomy were investigated. The patients' characteristics and histopathologic results of curettage and hysterectomy were extracted, and sensitivity and specificity and positive and negative predictive values of curettage were calculated...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28427775/nonoperative-management-of-atypical-endometrial-hyperplasia-and-grade-1-endometrial-cancer-with-the-levonorgestrel-intrauterine-device-in-medically-ill-post-menopausal-women
#16
William D Baker, Stuart R Pierce, Anne M Mills, Paola A Gehrig, Linda R Duska
OBJECTIVE: To assess the endometrial response rates to treatment with the levonorgestrel intrauterine device in post-menopausal women with atypical hyperplasia/endometrial intraepithelial neoplasia and grade 1 endometrioid (AH/EC) endometrial carcinoma who are not surgical candidates. METHODS: Chart review was undertaken of patients with AH/EC who underwent levonorgestrel intrauterine device insertion by a gynecologic oncologist within two academic health systems between 2002 and 2013...
April 18, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28427752/spontaneously-arising-tumours-and-tumour-like-lesions-of-the-cervix-and-uterus-in-83-pet-guinea-pigs-cavia-porcellus
#17
C Laik-Schandelmaier, R Klopfleisch, S Schöniger, G Weiffenbach, M Staudacher, H Aupperle
Tumours and tumour-like lesions are rare findings in the genital system of guinea pigs. The aim of the present study was to characterize nodular lesions in the cervix and uterus of guinea pigs submitted for histopathological diagnosis. Samples from 83 pet animals were investigated. Cases included 64 surgically excised masses including complete uteri (n = 37), parts from uteri containing masses (n = 8), complete masses (n = 12) or samples from masses (n = 7) and 19 complete necropsy examinations. In 55 of the cases, only solitary changes were observed; in 28 cases two or more lesions were diagnosed...
April 17, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28421714/endometrial-cells-on-pap-tests-ideal-reporting-is-more-complex-than-just-finding-the-right-age
#18
Gabor Fischer, Maha Haddad, Karen Cormier
BACKGROUND: The age for reporting normal endometrial cells (EMCs) on Pap tests was changed to ≥ 45 years in the latest Bethesda update (2014). This recommendation is solely based on age with no consensus on optimal reporting guidelines. METHODS: Pap tests with EMCs for women ≥40 years were retrieved from our Laboratory Information System (LIS). Patient age, last menstrual period (LMP) and available follow-up histology were recorded. Follow-up diagnoses were categorized as: no significant pathology, benign, hyperplasia ± atypia, or malignant...
April 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28416932/assessment-of-endometrial-sampling-and-histopathological-results-analysis-of-4-247-cases
#19
Zeynep Ozturk Inal, Hasan Ali Inal, Ilknur Kucukosmanoglu, Hasan Kucukkendirci
OBJECTIVE: This study aimed to investigate the relationship between indications and histopathological results in patients undergoing endometrial sampling. MATERIALS AND METHODS: Data of 4,247 patients undergoing endometrial sampling due to non-obstetric gynecological causes between January 2010 and October 2016 were retrospectively evaluated using the archives of the Gynecology and Obstetrics Clinic of Konya Training and Research Hospital. RESULTS: The mean age of patients was 46...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28405119/figo-s-palm-coein-classification-of-abnormal-uterine-bleeding-a-clinico-histopathological-correlation-in-indian-setting
#20
Devanshi Mishra, Shabana Sultan
INTRODUCTION: Abnormal uterine bleeding (AUB) is the commonest menstrual problem during perimenopause. The International Federation of Gynaecology and Obstetrics working group on menstrual disorders has developed a classification system (PALM-COEIN) for causes of the AUB in non-gravid women. The present study was conducted with the aim to study the two components of this system in clinical practice in general and to establish a clinico-pathological correlation of AUB with context of PALM component in particular...
April 2017: Journal of Obstetrics and Gynaecology of India
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