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endometrial hyperplasia

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https://www.readbyqxmd.com/read/29775456/maternal-obesogenic-diet-induces-endometrial-hyperplasia-an-early-hallmark-of-endometrial-cancer-in-a-diethylstilbestrol-mouse-model
#1
Theresa O Owuor, Michaela Reid, Lauren Reschke, Ian Hagemann, Suellen Greco, Zeel Modi, Kelle H Moley
Thirty-eight percent of US adult women are obese, meaning that more children are now born of overweight and obese mothers, leading to an increase in predisposition to several adult onset diseases. To explore this phenomenon, we developed a maternal obesity animal model by feeding mice a diet composed of high fat/ high sugar (HF/HS) and assessed both maternal diet and offspring diet on the development of endometrial cancer (ECa). We show that maternal diet by itself did not lead to ECa initiation in wildtype offspring of the C57Bl/6J mouse strain...
2018: PloS One
https://www.readbyqxmd.com/read/29750705/thickened-endometrium-in-postmenopausal-women-with-an-initial-biopsy-of-limited-benign-surface-endometrium-clinical-outcome-and-subsequent-pathologic-diagnosis
#2
Josephine K T Dermawan, Christine Hur, Maria G Uberti, Rebecca Flyckt, Tommaso Falcone, Jennifer Brainard, Fadi W Abdul-Karim
Endometrial biopsy or curetting is indicated for postmenopausal women with abnormal uterine bleeding and/or thickened endometrium. Often, endometrial biopsy or curetting yields limited benign surface endometrium, which may indicate insufficient sampling. This study addresses the clinical outcome and subsequent pathologic diagnoses in postmenopausal women who received this initial diagnosis. Among a total of 370 endometrial biopsy or curetting between 2012 and 2015, 192 (52%) were diagnosed as limited benign surface endometrial epithelium...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29741102/endometrial-pathology-in-recurrent-postmenopausal-bleeding-observational-study-of-385-women
#3
A Ghoubara, S Sundar, A A A Ewies
OBJECTIVES: Women with recurrent postmenopausal bleeding (PMB) are considered as being at higher risk for endometrial hyperplasia and cancer, and guidelines suggest offering hysterectomy in unexplained cases with repeated negative investigations. This study aims to determine the prevalence of endometrial pathology in women referred with recurrent PMB to help inform clinical practice. METHODS: This was an observational study of prospectively collected data over a 5-year period, including 1902 women referred to the PMB clinic...
May 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29716739/converging-endometrial-and-ovarian-tumorigenesis-in-lynch-syndrome-shared-origin-of-synchronous-carcinomas
#4
Anni Niskakoski, Annukka Pasanen, Noora Porkka, Samuli Eldfors, Heini Lassus, Laura Renkonen-Sinisalo, Sippy Kaur, Jukka-Pekka Mecklin, Ralf Bützow, Päivi Peltomäki
OBJECTIVE: The diagnosis of carcinoma in both the uterus and the ovary simultaneously is not uncommon and raises the question of synchronous primaries vs. metastatic disease. Targeted sequencing of sporadic synchronous endometrial and ovarian carcinomas has shown that such tumors are clonally related and thus represent metastatic disease from one site to the other. Our purpose was to investigate whether or not the same applies to Lynch syndrome (LS), in which synchronous cancers of the gynecological tract are twice as frequent as in sporadic cases, reflecting inherited defects in DNA mismatch repair (MMR)...
April 28, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29715112/low-dose-lng-ius-as-therapy-for-endometrial-hyperplasia-a-prospective-cohort-pilot-study
#5
Elise Thoresen Sletten, Marit Arnes, Anne Beate Vereide, Anne Ørbo
BACKGROUND/AIM: Progestin therapy has been accepted as therapy for low- and medium-risk endometrial hyperplasia. The aim of this study was to investigate the efficacy of the low-dose levonorgestrel-impregnated intrauterine system (LNG-IUS) 13.5 mg (Jaydess®, Bayer Pharmaceuticals, Berlin, Germany) as therapy for endometrial hyperplasia. PATIENTS AND METHODS: A total of 21 women with histologically-verified endometrial hyperplasia were prospectively treated with LNG-IUS Jaydess...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29715099/clinicopathological-characteristics-and-kras-mutation-status-of-endometrial-mucinous-metaplasia-and-carcinoma
#6
Ji-Youn Sung, Yoon Yang Jung, Hyun-Soo Kim
BACKGROUND/AIM: Mucinous metaplasia of the endometrium occurs as a spectrum of epithelial alterations ranging from the formation of simple, tubular glands to architecturally complex glandular proliferation with intraglandular papillary projection and cellular tufts. Endometrial mucinous metaplasia often presents a diagnostic challenge in endometrial curettage. MATERIALS AND METHODS: We analyzed the clinicopathological characteristics and the mutation status for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) of 11 cases of endometrial mucinous metaplasia...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29713518/the-ptenp1-pseudogene-unlike-the-pten-gene-is-methylated-in-normal-endometrium-as-well-as-in-endometrial-hyperplasias-and-carcinomas-in-middle-aged-and-elderly-females
#7
T F Kovalenko, K V Morozova, L A Ozolinya, I A Lapina, L I Patrushev
The tumor suppressor PTEN controls multiple cellular functions, including cell cycle, apoptosis, senescence, transcription, and mRNA translation of numerous genes. In tumor cells, PTEN is frequently inactivated by genetic mutations and epimutations. The aim of this study was to investigate the methylation patterns of the PTEN gene and its pseudogene PTENP1 as potential genetic markers of endometrial hyperplasia (EH) and endometrial carcinoma (EC). Methylation of the 5'-terminal regions of the PTEN and PTENP1 sequences was studied using methyl-sensitive PCR of genomic DNA isolated from 57 cancer, 43 endometrial hyperplasia, and normal tissue samples of 24 females aged 17-34 years and 19 females aged 45-65 years, as well as 20 peripheral venous blood samples of EC patients...
January 2018: Acta Naturae
https://www.readbyqxmd.com/read/29709726/rna-sequencing-reveals-significant-mirnas-in-atypical-endometrial-hyperplasia
#8
Shiqian Tang, Yinmei Dai
PURPOSE: In this paper, we aimed to investigate the miRNAs that played a regulatory role in the development of atypical endometrial hyperplasia (AEH). METHODS: RNA sequencing was performed for endometrial tissues from 3 AEH patients and 3 endometrial normal hyperplasia patients. RNA sequencing data were processed and differentially expressed (DE) miRNAs were identified between AEH and controls. The target genes for DE miRNAs were identified and mapped to the protein-protein interaction (PPI) network...
March 19, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29697394/specificities-of-endometrial-proliferation-stem-cell-index-distribution-in-endometrioid-carcinoma-of-different-grade-of-malignancy
#9
N Kikalishvili, R Beriashvili, T Muzashvili, G Burkadze
Endometrial neoplasia is the most common malignant tumor of female genital system in developed countries. The incidence of endometrial cancer has increased in the last years and despite advances in diagnosis and treatment, the death rates have steadily been increasing over the past 20 years. Therefore aspects of endometrial cancer development, pathogenesis and effective treatment is especially urgent to this day, as much of the risk for endometrial cancer development is influenced by the environment and lifestyle...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29683909/acog-committee-opinion-no-734-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#10
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29683904/acog-committee-opinion-no-734-summary-the-role-of-transvaginal-ultrasonography-in-evaluating-the-endometrium-of-women-with-postmenopausal-bleeding
#11
(no author information available yet)
Cancer of the endometrium is the most common type of gynecologic cancer in the United States. Vaginal bleeding is the presenting sign in more than 90% of postmenopausal women with endometrial carcinoma. Clinical risk factors for endometrial cancer, including but not limited to age, obesity, use of unopposed estrogen, specific medical comorbidities (eg, polycystic ovary syndrome, type 2 diabetes mellitus, atypical glandular cells on screening cervical cytology), and family history of gynecologic malignancy also should be considered when evaluating postmenopausal bleeding...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29676374/ovarian-fibroma-with-luteinized-thecal-cells-and-minor-sex-cord-element-a-rare-case-report
#12
Anjali Mathur, Ankit Seth, Leela Pant
Ovarian fibroma with minor sex cord element (MSCE) is a rare tumor. The increased estrogen production due to the presence of MSCE and/or luteinized thecal cells within fibroma can be a risk factor for endometrial hyperplasia or carcinoma.
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29665453/can-concurrent-high-risk-endometrial-carcinoma-occur-with-atypical-endometrial-hyperplasia
#13
Baki Erdem, Osman Aşıcıoğlu, Niyazi Alper Seyhan, Nuri Peker, Volkan Ülker, Özgür Akbayır
BACKGROUND: This study investigated the frequency of high-risk cancer types in hysterectomy material obtained from patients who were diagnosed with atypical endometrial hyperplasia (AEH) by endometrial sampling. MATERIALS AND METHODS: A total of 227 patients with AEH were retrospectively included in the study. Hysterectomy material was examined as both perioperative frozen section (FS) and paraffin-embedded permanent section (PS). Grade III tumors, grade II tumors larger than 2 cm, over 50% myometrial invasion, cervical involvement, and serous or clear cell histology were considered high-risk...
April 14, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29656794/immunohistochemistry-for-mismatch-repair-protein-deficiency-in-endometrioid-endometrial-carcinoma-yields-equivalent-results-when-performed-on-endometrial-biopsy-curettage-or-hysterectomy-specimens
#14
David B Chapel, S Diane Yamada, Matthew Cowan, Ricardo R Lastra
OBJECTIVE: Universal screening of endometrial cancer (EC) for Lynch syndrome (LS) has been increasingly implemented in the past five to ten years. Most pathologists initiate screening with immunohistochemistry (IHC) for mismatch repair proteins (MMRPs), using either pre-surgical samplings (endometrial biopsy or curettage, EMB/C) or hysterectomy specimens. We report a systematic assessment of the equivalence of IHC for LS screening on EMB/C versus hysterectomy specimens. METHODS: We identified 99 patients diagnosed with endometrioid EC and performed IHC for MMRPs MLH1, MSH2, MSH6, and PMS2 on their diagnostic EMB/C and paired hysterectomy specimen...
April 13, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29643878/is-postmenopausal-endometrial-fluid-collection-alone-a-risk-factor-for-endometrial-cancer
#15
Gulin Feykan Yegin Akcay, Emre Erdem Tas, Ayse Filiz Yavuz
Objective: To determine the usefulness of single-layer, ultrasonographic measurement of endometrial fluid collection (EFC) volume to predict endometrial pathology in asymptomatic postmenopausal patients. Methods: One hundred fifty asymptomatic postmenopausal women were analysed retrospectively from January 2012 to December 2016. After patients with endometrial hyperplasia/neoplasia were included in Group-I, and those with insufficient tissue, endometrial atrophy, or endometritis were included in Group-II; Groups one and two were compared with respect to primary (correlations between endometrial thickness and EFC volume) and secondary (correlations between demographic characteristics and EFC volume) outcomes...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29617699/abnormal-expression-of-pict-1-and-its-codon-389-polymorphism-is-a-risk-factor-for-human-endometrial-cancer
#16
Masafumi Yoshimoto, Aoi Tokuda, Kunihiko Nishiwaki, Kazuo Sengoku, Yuji Yaginuma
OBJECTIVE: The protein interacting with carboxyl terminus-1 (PICT-1) gene has been implicated as a tumor suppressor gene, and its alterations have been reported in several cancers. This study investigated the association of PICT-1 alterations with endometrial carcinogenesis. METHODS: We analyzed the entire coding region of the PICT-1 gene using polymerase chain reaction-single-strand conformation polymorphism and DNA sequencing to examine PICT-1 mutations in endometrial cancer...
April 4, 2018: Oncology
https://www.readbyqxmd.com/read/29615065/efficacy-safety-and-recurrence-of-new-progestins-and-selective-progesterone-receptor-modulator-for-the-treatment-of-endometriosis-a-comparison-study-in-mice
#17
Bo Liang, Ling Wu, Hui Xu, Chun Wai Cheung, Wen Ying Fung, Sze Wai Wong, Chi Chiu Wang
BACKGROUND: Current medical treatments for endometriosis are very limited. Progestin and selective progesterone receptor modulators (SPRM) are developed but their efficacy, safety, mechanism and recurrence in endometriosis are not fully studied. METHODS: In order to compare therapeutic, side effects and therapeutic actions of Esmya, Duphaston and Dienogest in endometriosis. Experimental endometriosis was induced by either intraperitoneal or subcutaneous mouse endometrium transplantation...
April 3, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29604099/evaluation-of-complete-blood-count-parameters-to-predict-endometrial-cancer
#18
Cigdem Yayla Abide, Evrim Bostanci Ergen, Ebru Cogendez, Cetin Kilicci, Faik Uzun, Enis Ozkaya, Ates Karateke
BACKGROUND: Complete blood count parameters have been introduced to be diagnostic biomarkers for many cancer-related diseases associated with inflammatory process. The aim of our study was to detect whether there is any relationship between benign or malignant endometrial pathologies and complete blood count parameters. METHODS: Four hundred and sixteen patients with a complaint of abnormal uterine bleeding who admitted to Zeynep Kamil Women and Children's Health Training and Research hospital between 2013 and 2016 and undergoing endometrial biopsy were included in the study...
March 31, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29588532/molecular-changes-preceding-endometrial-and-ovarian-cancer-a-study-of-consecutive-endometrial-specimens-from-lynch-syndrome-surveillance
#19
Anni Niskakoski, Annukka Pasanen, Heini Lassus, Laura Renkonen-Sinisalo, Sippy Kaur, Jukka-Pekka Mecklin, Ralf Bützow, Päivi Peltomäki
Molecular alterations preceding endometrial and ovarian cancer and the sequence of events are unknown. Consecutive specimens from lifelong surveillance for Lynch syndrome provides a natural setting to address such questions. To molecularly define the multistep gynecological tumorigenesis, DNA mismatch repair gene mutation carriers with endometrial or ovarian carcinoma or endometrial hyperplasia were identified from a nation-wide registry and endometrial biopsy specimens taken from these individuals during 20 years of screening were collected...
March 27, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29583028/progesterone-progestins-and-the-endometrium-in-perimenopause-and-in-menopausal-hormone-therapy
#20
A Gompel
It is well established that unopposed estrogen for hormone therapy in postmenopausal women (MHT) induces a dose-related stimulation of the endometrium associated with an increased risk of hyperplasia and endometrial cancer. Progesterone acts physiologically to counteract the proliferative effects of estradiol during the menstrual cycle. In MHT, progestogens protect the endometrium against the proliferative effects of estrogens in women with a uterus. Recent data suggest that, whereas micronized progesterone is apparently safer for the breast, it could be less efficient than synthetic progestin on the endometrium...
March 27, 2018: Climacteric: the Journal of the International Menopause Society
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