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Zhiyong Yan, Shusheng Che, Yingbin Jiao, JianPeng Wang, Xingze Li, Chao Wang
Cerebral cavernous malformations (CCMs) are present in up to 0.5% of the general population. While CCMs have been considered congenital lesions, numerous reports have observed de novo formations in patients with the familial form of CCM and in patients after cranial radiotherapy. Outside of these circumstances, there is scant evidence as to the potential etiologies of CCM. We present a 48-year-old woman with a medical history of endometrial hyperplasia concomitant endometrial polyps demonstrating a large de novo CCM, which grew to a large size in a period of 20 months...
June 18, 2018: World Neurosurgery
Yu Tsurekawa, Misaki Morita, Mary Ann Suico, Masataka Moriuchi, Yoshio Nakano, Mariam Piruzyan, Masafumi Takada, Sanako Fukami, Tsuyoshi Shuto, Hirofumi Kai
Psoriasis is a chronic skin disease caused by immune disorder. The chronic skin inflammation involves inflammatory molecules that are released from T lymphocytes and keratinocytes. Therefore, developing an anti-inflammatory therapy that is suitable for long-term treatment is needed. Electrical stimulation induces biological responses by modulating intracellular signaling pathways. Our previous studies showed that the optimized combination treatment of mild electrical stimulation (MES, 0.1-millisecond; ms, 55-pulses per second; pps) and heat shock (HS, 42°C) modulates inflammatory symptoms of metabolic disorders and chronic kidney disease in mice models and clinical trials...
June 21, 2018: Experimental Dermatology
T J Schipper, P U Dijkstra, F K L Spijkervet
Unilateral condylar hyperplasia is a rare growth disorder originating in the growth centre of the mandibular condyles and resulting in facial asymmetry. Primary treatment consists of condylectomy. In this cross-sectional research, limitations in mandibular function and oral health related quality of life were measured with the Mandibular Function Impairment Questionnaire and the Oral Health Impact Profile (NL49). The study included 17 patients who underwent treatment for unilateral condylar hyperplasia with a condylectomy in the University Medical Center Groningen between 1997 and 2012...
June 2018: Nederlands Tijdschrift Voor Tandheelkunde
Jill M Hoffman, Aristea Sideri, Jonathan J Ruiz, Dimitris Stavrakis, David Q Shih, Jerrold R Turner, Charalabos Pothoulakis, Iordanes Karagiannides
Mesenteric adipose tissue hyperplasia is a hallmark of Crohn's disease (CD). Recently, we showed that mesenteric adipose-derived stromal cells (ADSCs) from CD, ulcerative colitis, and control patients synthesize and release adipokines in a disease-dependent manner. Here we examined the expression profiles of CD and control patient-derived mesenteric ADSCs and studied the effects of their extracellular mediators on colonocyte signaling in vitro and experimental colitis in vivo. ADSCs were isolated from mesenteric fat of control and CD patients...
2018: Cellular and Molecular Gastroenterology and Hepatology
Mengwei Xu, Tao Xu
The present study investigated the expression and clinical significance of micro-ribonucleic acid-23a (miR-23a) and metastasis suppressor 1 (MTSS1) in diffuse large B-cell lymphoma (DLBCL). A total of 70 cases of tumor tissues of patients with DLBCL and 30 cases of reactive lymphoid hyperplasia tissues were collected. OCI-LY10 cell was transfected with miR-23a antisense oligonucleotide (miR-23a ASO). The expression of miR-23a and MTSS1 in tumor tissues of patients with DLBCL and reactive lymphoid hyperplasia tissues were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry...
July 2018: Oncology Letters
Ze-Hua Hu, Zhao-Fen Yu, Jin Huang, Xue-Fei Chen, De-Bin Huang
OBJECTIVE: To investigate the effects of Coriaria Sinica Maxim's extract(CSME) on microcirculation and oxidative stress of wounds in rats with deep second-degree burn. METHODS: One hundred and eighty rats were randomly divided into normal saline group(NS), white petroleum group(WPL), silver sulfadiazine group (SSD), Coriariasinica Maxim's extract group which were divided into low dose(CSME-L),middle dose(CSME-M) and high dose(CSME-H). After anesthesia with burn instrument to burn the hair removal area of rats, these wounds were confirmed by pathological results with deep second degree burns...
January 8, 2018: Chinese Journal of Applied Physiology
Chelsea C Estrada, Praharshasai Paladugu, Yiqing Guo, Jesse Pace, Monica P Revelo, David J Salant, Stuart J Shankland, Vivette D D'Agati, Anita Mehrotra, Stephanie Cardona, Agnieszka B Bialkowska, Vincent W Yang, John C He, Sandeep K Mallipattu
Pathologic glomerular epithelial cell (GEC) hyperplasia is characteristic of both rapidly progressive glomerulonephritis (RPGN) and subtypes of focal segmental glomerulosclerosis (FSGS). Although initial podocyte injury resulting in activation of STAT3 signals GEC proliferation in both diseases, mechanisms regulating this are unknown. Here, we show that the loss of Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor, enhances GEC proliferation in both RPGN and FSGS due to dysregulated STAT3 signaling...
June 21, 2018: JCI Insight
F Qin, Z C Huang, M Q Cai, X F Xu, T T Lu, Q Dong, A M Wu, Z Z Lu, C Zhao, Y Guo
Objective: To investigate the value of stereotactic biopsy in the accurate diagnosis of lesions in the brain stem and deep brain. Methods: A total of 29 consecutive patients who underwent stereotactic biopsy of brainstem and deep brain lesions between May 2012 and January 2018 were retrospectively reviewed. The Cosman-Roberts-Wells (CRW) stereotactic frame was installed under local anesthesia. Thin-layer CT and MRI scanning were performed. Target coordinates were calculated by inputting CT-MRI data into the radionics surgical planning system...
June 12, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
K A Kuznetsov, M V Khar'kova, A A Karpenko, P P Laktionov
Using stents for endovascular restoration of blood flow made a revolution in vascular surgery, however, despite numerous variants of stents presented on the pharmacological market, there are no stents which would completely solve the problem of restenosis in the area of stent placement. In order to decrease growth of the neointima of the stented portions of vessels, stents coated with cytostatic and cytotoxic agents were worked out. To optimize the rate of drug release it was suggested to apply them in a mixture with biodegradable or biostable polymers...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Pedro Paulo Barros, Gisele Mara Silva Gonçalves, Gustavo Henrique da Silva, Maria Clara Villaça Dias Bastos, Loren Nogaroto Ramos, Marilia Marinello Fernandes
PURPOSE: To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats. METHODS: The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH...
May 2018: Acta Cirúrgica Brasileira
Akira Miyajima
With an increase in their prevalence, it has become apparent that both benign prostatic hyperplasia and radical prostatectomy for cancer can induce inguinal hernia development. An inguinal hernia is a common late complication following radical prostatectomy, with an occurrence rate of 12-25%. Following radical prostatectomy, the space of Retzius can develop adhesions to surrounding tissue, often causing difficulty during inguinal hernia repair. Conversely, inguinal hernia repair before radical prostatectomy also induces severe adhesions around the space of Retzius and causes difficulty during radical prostatectomy...
June 19, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
Alex Borchert, David A Leavitt
PURPOSE OF REVIEW: Review how the various surgical treatments for benign prostatic hyperplasia and lower urinary tract symptoms impact on male sexual health and function. RECENT FINDINGS: The interplay between benign prostatic hyperplasia and erectile function is complex, and the conditions seem linked. Most cavitating procedures to improve male voiding will degrade ejaculatory and possibly erectile function. Many of the newer minimally invasive therapies appear to preserve sexual function in the short term while sacrificing some of the voiding improvements realized with more complete removal of the prostate adenoma...
June 19, 2018: Current Urology Reports
Suleyman Sami Cakir, Emre Can Polat, Levent Ozcan, Huseyin Besiroglu, Alper Ötunctemur, Emin Ozbek
Background: To investigate the effect of asymptomatic inflammatory prostatitis on clinical outcomes of patients undergoing trans urethral resection of prostate due to benign prostatic hyperplasia. Materials and methods: A total of 514 patients were enrolled in the study. Clinical parameters and pathological results were compared before and one year after surgery. Results: Of the patients 310 were diagnosed with purely benign prostatic hyperplasia and the others were diagnosed with both prostatic inflamation (cathegory IV) and benign prostatic hyperplasia...
June 2018: Prostate International
Koin Lon Shum, Yuyang Tan
Pneumocephalus, the presence of air within the cranium, commonly suggests a breach in the meningeal layer or an intracranial infection by a gas-producing organism. Trauma is the most common cause of pneumocephalus, followed by cranial surgery. Other causes include infection and intracranial neoplasm. An 87-year-old man was conveyed to the emergency department after being found to be drowsy by his helper. He was noted to have a new onset right-sided hemiparesis. Past medical history was significant for hypertension, stage 5 chronic kidney disease, cerebrovascular accident, pacemaker insertion for sick sinus syndrome, transurethral resection of the prostate for benign prostatic hyperplasia, and pulmonary tuberculosis...
April 14, 2018: Curēus
Deep Dutta, Pradeep Kumar Gupta, Meha Sharma, Nishikant Avinash Damble, Renu Madan, Shruti Dogra
Parathyroid cysts are extremely rare and are rarely associated with primary hyperparathyroidism (PHPT), which are difficult to localise, as they are 99m Tc-sesta-methoxyisobutylisonitrile (sestaMIBI) negative. We report for the first time the utility of 18 F-fluorocholinepositron emission tomography/computerised tomography (PC-PET/CT) in localising parathyroid cyst causing normocalcemic PHPT. A 76-year-old lady with progressively worsening osteoporosis from 2014-2017 (in spite of annual zolendronic acid infusions, daily calcium and vitamin-D supplementation) with persistently normal serum calcium and vitamin D, but elevated parathyroid hormone, had normal sestaMIBI scans of the neck on multiple occasions...
April 2018: European Endocrinology
Alain P Gobert, Nicole T Al-Greene, Kshipra Singh, Lori A Coburn, Johanna C Sierra, Thomas G Verriere, Paula B Luis, Claus Schneider, Mohammad Asim, Margaret M Allaman, Daniel P Barry, John L Cleveland, Christina E Destefano Shields, Robert A Casero, M Kay Washington, M Blanca Piazuelo, Keith T Wilson
Polyamines have been implicated in numerous biological processes, including inflammation and carcinogenesis. Homeostatic regulation leads to interconversion of the polyamines putrescine and the downstream metabolites spermidine and spermine. The enzyme spermine oxidase (SMOX), which back-converts spermine to spermidine, contributes to regulation of polyamine levels, but can also have other effects. We have implicated SMOX in gastric inflammation and carcinogenesis due to infection by the pathogen Helicobacter pylori ...
2018: Frontiers in Immunology
Isabella W Martin, Aaron E Atkinson, Xiaoying Liu, Arief A Suriawinata, Joel A Lefferts, Mikhail Lisovsky
The diagnosis of Candida esophagitis can be challenging when the epithelium containing Candida filamentous forms is not readily seen or is entirely sloughed away. Mucosal inflammation could be helpful diagnostically, if distinctive. However it is thought to be nonspecific in Candida esophagitis. The goal of this retrospective study was to identify features of mucosal inflammation helpful in alerting a pathologist to the possibility of Candida esophagitis when Candida mycelia are not readily observed. The study group consisted of 99 consecutive cases of Candida esophagitis and a control group of 64 consecutive cases of reflux esophagitis diagnosed at our institution from 2008-2016...
June 19, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Dominik Abt, Lukas Hechelhammer, Gautier Müllhaupt, Stefan Markart, Sabine Güsewell, Thomas M Kessler, Hans-Peter Schmid, Daniel S Engeler, Livio Mordasini
OBJECTIVE: To compare prostatic artery embolisation (PAE) with transurethral resection of the prostate (TURP) in the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia in terms of patient reported and functional outcomes. DESIGN: Randomised, open label, non-inferiority trial. SETTING: Urology and radiology departments of a Swiss tertiary care centre. PARTICIPANTS: 103 patients aged ≥40 years with refractory lower urinary tract symptoms secondary to benign prostatic hyperplasia were randomised between 11 February 2014 and 24 May 2017; 48 and 51 patients reached the primary endpoint 12 weeks after PAE and TURP, respectively...
June 19, 2018: BMJ: British Medical Journal
Ben Challacombe, Tarun Sabharwal
No abstract text is available yet for this article.
June 19, 2018: BMJ: British Medical Journal
Patricia Hernández-Ríos, Iris Espinoza, Macarena Salinas, Fernando Rodríguez-Castro, Mauricio Baeza, Marcela Hernández
BACKGROUND: Many gingival lesions are not induced by plaque. The aim of this study was to analyze the frequency of biopsied non-plaque-induced gingival lesions (NPIGL) in a Chilean population. METHODS: One thousand twelve cases of biopsied gingival lesions with confirmed anatomopathologic diagnosis were included, from the records of the Oral Pathology Referral Institute (OPRI), Faculty of Dentistry, University of Chile, between years 1990 and 2009. RESULTS: The most frequent non plaque-induced gingival lesions categories from biopsied cases included hyperplastic lesions, malignancies and benign neoplasms...
June 19, 2018: BMC Oral Health
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