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https://www.readbyqxmd.com/read/29908338/surgical-and-oncologic-outcomes-of-radical-abdominal-trachelectomy-versus-hysterectomy-for-stage-ia2-ib1-cervical-cancer
#1
Jing Guo, Ying Zhang, Xiaofei Chen, Lin Sun, Kai Chen, Xiugui Sheng
STUDY OBJECTIVE: To compare the surgical and oncologic outcomes between radical abdominal trachelectomy and radical hysterectomy (RH) for stage IA2-IB1 cervical cancer. DESIGN: Ⅱ-2: : Retrospective cohort study. SETTING: Shandong Cancer Hospital. PATIENTS: 329 patients with IA2-IB1 cervical cancer. INTERVENTIONS: All patients underwent radical abdominal trachelectomy (ART) or RH. MEASUREMENTS AND MAIN RESULTS: All patients were divided into ART (n=143) and RH (n=186) group according to surgical approach...
June 13, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29907432/sensitivity-and-specificity-of-sentinel-lymph-node-biopsy-in-patients-with-oral-squamous-cell-carcinomas-using-indocyanine-green-fluorescence-imaging
#2
Ahmed Al-Dam, Clarissa Precht, Armelle Barbe, Carsten Kohlmeier, Henning Hanken, Johannes Wikner, Gerhard Schön, Max Heiland, Alexandre T Assaf
PURPOSE: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer. PATIENTS AND METHODS: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection...
May 23, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29904822/spatial-relationship-of-2-deoxy-2-18-f-fluoro-d-glucose-positron-emission-tomography-and-magnetic-resonance-diffusion-imaging-metrics-in-cervical-cancer
#3
John M Floberg, Kathryn J Fowler, Dominique Fuser, Todd A DeWees, Farrokh Dehdashti, Barry A Siegel, Richard L Wahl, Julie K Schwarz, Perry W Grigsby
BACKGROUND: This study investigated the spatial relationship of 2-deoxy-2-[18 F]-fluoro-D-glucose positron emission tomography ([18 F]FDG-PET) standardized uptake values (SUVs) and apparent diffusion coefficients (ADCs) derived from magnetic resonance (MR) diffusion imaging on a voxel level using simultaneously acquired PET/MR data. We performed an institutional retrospective analysis of patients with newly diagnosed cervical cancer who received a pre-treatment simultaneously acquired [18 F]FDG-PET/MR...
June 15, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29904734/hazards-of-sparing-the-ipsilateral-parotid-gland-in-the-node-positive-neck-with-intensity-modulated-radiation-therapy-spatial-analysis-of-regional-recurrence-risk
#4
Allen M Chen, Taeko Yoshizaki, Pin-Chieh Wang, Darlene Veruttipong, Phillip J Beron, Robert Chin, Argin G Mikaeilian, Minsong Cao
Purpose: The practice of deliberately sparing the ipsilateral parotid gland with intensity modulated radiation therapy (IMRT) in patients with node-positive head and neck cancer is controversial. We sought to compare the clinical outcomes among consecutive cohorts of patients with head and neck cancer who were treated with differing strategies to spare the parotid gland that is ipsilateral to the involved neck using IMRT. Methods and materials: A total of 305 patients were treated with IMRT for node-positive squamous cell carcinoma of the head and neck...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29902852/-rescue-of-a-thyroid-cancer-patient-with-subglottic-carcinoma-and-infringement-of-cervical-trachea-under-extracorporeal-circulation-a-case-report
#5
C Y Yao, Y H Liu, C B Gao
No abstract text is available yet for this article.
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29902845/-clinical-practice-of-repair-of-large-tracheal-defects-with-local-tension-free-flaps
#6
Y H Wu, S Y Liu
Objective: To investigate a simple and practical method for the repair of large tracheal defects. Methods: From April 2015 to October 2017, 10 patients with large tracheal wall defects after thyroid carcinoma underwent two phase repair with cervical tension free flap with modified design. In the longitudinal direction of the leakage, design two pieces of random flap outside the top angle of 45°, respectively, and the side turn double flip flap to repair the leak, outward and upward forming tension, avoid collapse after healing...
June 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29902371/prevalence-of-intraepithelial-lesion-in-cervical-screening-cytology-in-a-first-level-care-unit
#7
José Gabriel Solís, Tomás Iván Briones-Torres
Background: Cervical cancer represents the second leading cause of malignant neoplasm mortality in women globally. Cervical cytology is the most important screening study. It is therefore of interest to know the prevalence of cytological alterations in the Mexican population. In this study the objective was to calculate the prevalence of intraepithelial lesion in cervical screening cytology. Methods: An observational, descriptive and cross-sectional study was developed; the sample was 379 patients from 21 to 64 years of age; we included patients who underwent cervical screening cytology registered in the Detección Oportuna de Cáncer Cervicouterino (DOC-CACU) program database...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29902144/paratiroidectomia-miniinvasiva-videoasistida-minimally-invasive-video-assisted-parathyroidectomy
#8
Luis Gramática, Rodolfo Raúl Cecenarro, Facundo Jorge Antueno, Noelia Susana Villablanca
ResumenObjetivo. Mostrar nuestra experiencia realizando la paratiroidectomía miniinvasiva video-asistida con abordaje central para el tratamiento de pacientes con hiperparatiroidismo primario, sin utilizar el monitoreo intraoperatorio de paratohormona (mipth), basados únicamente en la concordancia de dos estudios de localización preoperatorios.Material y métodos. Se seleccionaron 27 pacientes con diagnóstico de hiperparatiroidismo primario, a los cuales se les realizó previo su consentimiento para la realización de un abordaje miniinvasivo, una ecografía cervical y una centellografía sesta-MIBI como estudios de localización pre-operatorios, los cuales fueron concordantes en todo ellos...
April 11, 2018: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/29901522/expression-of-markers-of-m%C3%A3-llerian-clear-cell-carcinoma-in-primary-cervical-and-vaginal-gastric-type-adenocarcinomas
#9
Karen L Talia, Richard Wing-Cheuk Wong, W Glenn McCluggage
The incidence of cervical adenocarcinoma, both absolute and relative to squamous cell carcinoma, is increasing. Most cervical adenocarcinomas are human papillomavirus associated, although non-human papillomavirus-associated neoplasms exist; the latter include gastric-type adenocarcinoma (GAS) and clear cell carcinoma (CCC). Histologically, these 2 tumors may superficially resemble one other and although morphologic evaluation usually permits a correct diagnosis, immunohistochemistry may be required to resolve diagnostic uncertainty, especially in a small biopsy specimen...
June 12, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29901176/a-novel-biphenyl-urea-compound-tpd7-stimulates-apoptosis-through-modulating-fas-signaling-and-bcl-2-family-proteins-in-cervical-cancer
#10
Yingzhuan Zhan, Han Zhang, Bingling Dai, Yanmin Zhang, Jie Zhang, Langchong He
We recently reported that TPD7 suppressed tumor cell proliferation, and inhibited invasion, through the suppression of C-X-C chemokine receptor type 4 (CXCR4). In the present study, we investigated the anticancer effect of TPD7 on apoptosis and invasion of cervical cancer HeLa cells. Cell cycle analysis revealed that TPD7 decreased cyclin-dependent kinase (CDK)1 and cyclin D1 expression, and increased cyclin A expression, following S phase blockade. TPD7 induced chromatin condensation and significantly elevated the number of apoptotic cells, suggesting that its inhibitory effect on HeLa cells was due to the induction of cell cycle blockade and apoptosis...
June 4, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901171/sipi-soup-inhibits-cancer%C3%A2-associated-fibroblast-activation-and-the-inflammatory-process-by-downregulating-long-non%C3%A2-coding-rna-hipk1%C3%A2-as
#11
Bingxiu Zhou, Yuanyuan Yu, Lixia Yu, Binfu Que, Rui Qiu
Sipi soup (SPS), the aqueous extract derived from the root bark of Sophora japonical L, Salix babylonica L., Morus alba L., as well as Amygdalus davidiana (Carr.) C. de Vos, is a traditional Chinese medicine frequently used to prevent and treat infection and inflammation. However, the role of SPS in cancer‑associated fibroblasts (CAFs) require further investigation. In the present study, the effects of SPS on fibroblast inactivation and the underlying mechanism were investigated. Reverse transcription‑quantitative polymerase chain reaction was used to analyze the mRNA expression levels of fibroblast activation protein (FAP), interleukin (IL)‑6, α‑smooth muscle actin (α‑SMA) and programmed cell death 4 (PDCD4)...
June 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29898440/results-of-cervical-cancer-screening-in-the-rural-population-of-lucknow-west-india-through-a-camp-approach
#12
Jata S Misra, Anand N Srivastava, Hem P Gupta
OBJECTIVE: Cytological screening was carried out in rural women of Lucknow West, India, through a camp approach to detect cervical cancer in its preinvasive phase and to see whether the primitive living conditions in the villages have any effect on the incidence of precancer and carcinoma of the cervix and the associated predisposing factors of cervical carcinogenesis. STUDY DESIGN: During a span of 4 years (May 2013 to March 2017), a total of 135 camps were organized under the auspice of Era's Lucknow Medical College and Hospital (Lucknow, India)...
June 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29896404/primary-breast-cancer-relapse-as-metastasis-to-the-cervix-uteri-a-case-report
#13
Aude Thouvenot, Yasmine Bizet, Laurent S Baccar, Michele Lamuraglia
Metastasis of non-gynaecological tumours to the cervix is a rare event, and metastasis from breast cancer is even rarer, with only a limited number of such cases reported in the literature to date. We herein report the case of an 86-year-old female patient who had undergone mastectomy and axillary lymphadenectomy for invasive ductal cell breast carcinoma 2 years prior, followed by adjuvant hormonal therapy with letrozole. During hospitalization for anemia associated with an inflammatory syndrome and abdominal pain with menorrhagia, an abdominal ultrasound examination revealed a suspicious uterine mass with irregular contours and abnormal vascularization with associated increase of the blood level of cancer antigen 15-3 to 34 kU/l...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29896403/evaluation-of-tumor-free-distance-and-depth-of-myometrial-invasion-as-prognostic-factors-in-endometrial-cancer
#14
Raoudha Doghri, Salma Chaabouni, Yoldez Houcine, Lamia Charfi, Nadia Boujelbene, Maha Driss, Karima Mrad
The aim of the study was to investigate whether the tumor free distance (TFD), which is the distance in millimeters between the deepest point of invasion and the serosal surface, and absolute depth of invasion (DMI), the distance in millimeters between the endomyometrial junction and the deepest point of myometrial invasion, are useful in surgical staging and in predicting prognosis. The present study retrospectively analyzed 62 cases of endometrial carcinoma with complete surgical staging, carried out over a 4 and half-year period (January 2003 to June 2007)...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29896225/ellagic-acid-induces-hela-cell-apoptosis-via-regulating-signal-transducer-and-activator-of-transcription-3-signaling
#15
Lian-Wei Li, Chao Na, Song-Yu Tian, Jie Chen, Rong Ma, Ying Gao, Ge Lou
Ellagic acid has been reported to possess various activities, including anti-inflammatory, anti-oxidative, antiviral and anticancer abilities. However, the effect and underlying molecular mechanism of ellagic acid on cervical carcinoma remain unclear. Therefore, the present study aimed to investigate the effects of ellagic acid on human cervical carcinoma cells and the molecular mechanism involved. The present study assessed the survival of HeLa cells cultured in vitro using an MTT assay. Apoptosis rate and cell cycle of HaLa cells were measured using an Annexin V-Fluorescein isothiocyanate/propidium iodide Apoptosis Detection and Cell Cycle Analysis kits, respectively, following treatment with varying concentrations of ellagic acid...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895092/metastatic-hepatocellular-carcinoma-to-the-occipito-cervical-junction-a-unique-case-and-literature-review
#16
Federica Di Marco, Giada M Vecchio, Biagio Di Stefano, Antonio Pesce, Stefano Puleo
No abstract text is available yet for this article.
June 12, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29893470/cip2a-facilitates-the-g1-s-cell-cycle-transition-via-b-myb-in-human-papillomavirus-16-oncoprotein-e6-expressing-cells
#17
Yonghao Tian, Hanxiang Chen, Lijun Qiao, Wenhao Zhang, Jingyi Zheng, Weiming Zhao, Jason J Chen, Weifang Zhang
Infection with high-risk human papillomaviruses (HR-HPVs, including HPV-16, HPV-18, HPV-31) plays a central aetiologic role in the development of cervical carcinoma. The transforming properties of HR-HPVs mainly reside in viral oncoproteins E6 and E7. E6 protein degrades the tumour suppressor p53 and abrogates cell cycle checkpoints. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that is involved in the carcinogenesis of many human malignancies. Our previous data showed that CIP2A was overexpressed in cervical cancer...
June 12, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29893086/-selection-of-dna-aptamers-to-cervical-intraepithelial-neoplasia-by-selex
#18
Wenhui Li, Dalin Shi, Ruhan Jia, Jing Yang, Yanyan Zhang, Wei Chen, Yuewu Han
An in vitro synthesized random ssDNA library was subjected to 12 rounds of selection against anti-screening cells and sieving cells by SELEX. Normal and inflammatory cervical exfoliation cells were selected as anti-screening cells, and the cervical exfoliation cells of low-grade squamous intraepithelial lesion (CIN1), high-grade squamous intraepithelial lesion (CIN2, CIN3) and cervical carcinoma were selected as sieving cells during the screening process. Then, the highly specific aptamer CIN-Ap4 was established by the analysis of the specificity, affinity and cell immunofluorescence, which can be used as biomarker for Cervical Intraepithelial Neoplasia...
May 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/29885996/multi-institutional-analysis-of-vaginal-brachytherapy-alone-for-women-with-stage-ii-endometrial-carcinoma
#19
Matthew M Harkenrider, Brendan Martin, Karina Nieto, Christina Small, Ibrahim Aref, David Bergman, Anupama Chundury, Mohamed A Elshaikh, David Gaffney, Anuja Jhingran, Larissa Lee, Ima Paydar, Kisuk Ra, Julie Schwarz, Cameron Thorpe, Akila N Viswanathan, William Small
PURPOSE: To investigate the survival endpoints in women with International Federation of Gynecology and Obstetrics (FIGO) stage II endometrial cancer who received adjuvant vaginal brachytherapy (VBT) alone using multi-institutional pooled data. METHODS AND MATERIALS: We performed a multi-institutional analysis of surgically staged patients with FIGO stage II endometrioid-type endometrial cancer treated with VBT alone. Patient, tumor, and treatment characteristics were collected and analyzed...
April 24, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29884710/concomitant-sarcoidosis-and-papillary-thyroid-cancer-with-severe-hypercalcaemia-as-the-main-symptom
#20
Mikael Groth Riis, Kasper Svendsen Juhl, Jens Meldgaard Bruun
A 65-year-old Caucasian man was admitted to our hospital due to incidental finding of plasma ionised calcium=1.83 mmol/L. During the previous months, he had felt more tired and had experienced an unintended weight loss of 6-8 kg. A CT scan revealed an inhomogeneous thyroid gland and enlarged lymph nodes along the cervical vessels and in the mediastinum. The patient underwent total thyroidectomy and, at the same time, two lymph nodes were removed. Histological examination of the thyroid gland revealed papillary thyroid carcinoma (PTC), T1aN0M0, and histological examination of the lymph nodes showed non-caseating granulomatous inflammation...
June 8, 2018: BMJ Case Reports
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