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https://www.readbyqxmd.com/read/28633765/neck-dissection-for-unknown-cancer-of-the-head-and-neck-in-the-era-of-chemoradiation
#1
Mark J Amsbaugh, Mehran Yusuf, Jeremy Gaskins, Craig Silverman, Kevin Potts, Jeffrey Bumpous, Rebecca Redman, Cesar Perez, Neal Dunlap
PURPOSE: To report outcomes for patients with cervical lymph node metastases from an unknown primary site of the head and neck treated with either non-operative therapy or neck dissection followed by adjuvant therapy. MATERIALS AND METHODS: All patients with squamous cell carcinoma of an unknown primary site of the head or neck seen between 2003 and 2013 were reviewed. The Kaplan-Meier method was used to estimate overall survival, local recurrence free survival, loco-regional recurrence free survival, and progression free survival...
June 14, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28631565/genetic-and-epigenetic-alterations-affecting-park-2-expression-in-cervical-neoplasm-among-north-indian-patients
#2
Afreen Naseem, Zafar Iqbal Bhat, Ponnusamy Kalaiarasan, Bhupender Kumar, Gauri Gandhi, M Moshahid Alam Rizvi
The recent investigation on PARK-2, a putative tumor suppressor gene, has found that it has been altered in multiple human malignancies. However, the clinical impact of PARK-2 alteration in uterine cervix carcinoma has not yet been studied. Therefore, we aimed to examine mutations, promoter hypermethylation, and protein expression of PARK-2 among the North Indian patients and their association with clinical parameters to evaluate the implication of PARK-2 in the genesis of cervical cancer. A total of 168 patient samples were processed for mutational analysis by single-strand conformation polymorphism, sequencing, and further in silico analysis of the identified mutations...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28627989/computed-tomography-detection-of-extracapsular-spread-of-squamous-cell-carcinoma-of-the-head-and-neck-in-metastatic-cervical-lymph-nodes
#3
Joshua A Carlton, Adam W Maxwell, Lyndsey B Bauer, Sara M McElroy, Lester J Layfield, Humera Ahsan, Ajay Agarwal
Background and purpose In patients with squamous cell carcinoma of the head and neck (HNSCC), extracapsular spread (ECS) of metastases in cervical lymph nodes affects prognosis and therapy. We assessed the accuracy of intravenous contrast-enhanced computed tomography (CT) and the utility of imaging criteria for preoperative detection of ECS in metastatic cervical lymph nodes in patients with HNSCC. Materials and methods Preoperative intravenous contrast-enhanced neck CT images of 93 patients with histopathological HNSCC metastatic nodes were retrospectively assessed by two neuroradiologists for ECS status and ECS imaging criteria...
June 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28627709/the-homologous-recombination-protein-rad51-is-a-promising-therapeutic-target-for-cervical-carcinoma
#4
Qian Chen, Dongge Cai, Mu Li, Xiaoling Wu
RAD51 is one of the pivotal enzymes for DNA double-strand break (DSB) repair by the homologous recombination (HR) pathway, which implies it as a promising and novel target for cancer therapy. Recent findings have indicated RAD51 protein is overexpressed in a variety of tumors. The high-expression of RAD51 is related to poor prognosis. RAD51 is involved in the repair of DNA damage and the generation of genetic diversity by an evolutionarily conserved mechanism. However, the exact mechanism of Rad51 in the progression of cervical cancer remains unclear...
June 15, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28626101/-comparison-of-short-term-outcomes-between-minimally-invasive-mckeown-esophagectomy-and-ivor-lewis-esophagectomy-for-esophageal-cancer
#5
Xiong Peng, Yun Chen, Abdillah Nassor Juma, Yanqing Wang, Yuan Zhou, Yang Jiao, Weixing Zhang, Wei Zhuang
To summarize the outcomes of 74 patients with minimally invasive McKeown esophagectomy (MIE-McKeown), and to discuss the short-term outcomes by comparing with Ivor-Lewis esophagectomy (ILE) procedure.
 Methods: A total of 74 patients with esophageal carcinoma underwent MIE-McKeown in Xiangya Hospital from November 2014 to July 2016 were retrospectively reviewed, and 85 patients underwent ILE procedure were selected as a control group. Perioperative and short-term outcomes were analyzed.
 Results: Compared with the ILE group, patients underwent MIE-McKeown had less blood loss, less pulmonary infection, longer resection length and more harvested lymph nodes (P<0...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28625962/application-research-on-nerve-sparing-radical-hysterectomy-for-rectal-function
#6
Yuehui Su, Mengzhen Zhang, Weiwei Zhang, Huirong Shi
This paper aims to discuss the clinical significance of laparotomy nerve sparing radical hysterectomy (NSRH) on rectal function of early cervical cancer patients, compared with conventional radical hysterectomy. 30 cases of early cervical carcinoma patients who had received surgery in the First Affiliated Hospital of Zhengzhou University from June 2010 to June 2014 were selected as subjects. Patients were divided into two groups, with 15 in each gorup, in which Group A had received NSRH, B received CRH, and all them were in stage IB-IIA1...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28624429/squamous-cell-carcinoma-of-the-retromolar-trigone-treatment-outcomes
#7
Hideaki Nishi, Takeshi Shinozaki, Toshifumi Tomioka, Takashi Maruo, Ryuichi Hayashi
OBJECTIVE: Squamous cell carcinoma (SCC) of the retromolar trigone is uncommon, accounting for 1.4% of all oral cancer cases in Japan. Few studies have examined the optimal treatment for this cancer. The aim of this study was to evaluate the outcome of treatment for primary SCC of the retromolar area. METHODS: We retrospectively analyzed the outcome and prognosis of 45 patients (38 men, 7 women) with SCC of the retromolar trigone who underwent treatment in our department between July 1992 and March 2011...
June 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28624026/the-prediction-of-the-treatment-response-of-cervical-nodes-using-intravoxel-incoherent-motion-diffusion-weighted-imaging
#8
Simona Marzi, Francesca Piludu, Giuseppe Sanguineti, Laura Marucci, Alessia Farneti, Irene Terrenato, Raul Pellini, Maria Benevolo, Renato Covello, Antonello Vidiri
PURPOSE: To investigate the predictive role of Intravoxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI) parameters on cervical nodal response to chemo-radiotherapy (CRT) of head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Patients with pathologically confirmed HNSCC were included in the present prospective study, having at least one positive cervical lymph node (LN). They received concomitant CRT and underwent three serial IVIM-DWI investigations: before, at mid-treatment and after treatment completion...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28623908/programmed-death-ligand-1-pd-l1-is-expressed-in-a-significant-number-of-the-uterine-cervical-carcinomas
#9
Opal L Reddy, Peter I Shintaku, Neda A Moatamed
BACKGROUND: The programmed death-1/programmed death-ligand-1 (PD-1/PD-L1) immune regulatory axis has emerged as a promising new target for cancer therapeutics, with lasting responses seen in the treatment of metastatic renal and lung carcinomas, as well as melanomas. As tumor surface expression of PD-L1 has been found to correlate with objective responses to anti-PD-L1 immunotherapies, we investigated the expression of PD-L1 in human cervical tumors and provide an adopted scoring system for the systematic evaluation of PD-L1 staining...
June 17, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28623723/dft-b3lyp-calculations-in-vitro-cytotoxicity-and-antioxidant-activities-of-steroidal-pyrimidines-and-their-interaction-with-hsa-using-molecular-docking-and-multispectroscopic-techniques
#10
Abad Ali, Mohd Asif, Parvez Alam, Mohammad Jane Alam, Mohd Asif Sherwani, Rizwan Hasan Khan, Shabbir Ahmad, Shamsuzzaman
As a part of our continuing program on the synthesis of steroidal heterocycles, it has been prepared a series of novel steroidal pyrimidine derivatives 4-6via TMSCl, steroidal ketones (1c-3c), urea and benzaldehyde. The systems presented here, are novel scaffolds and have not been described before at 6th position of steroidal-6-one (1c-3c). Structural assignment of newly synthesized compounds was performed by DFT/B3LYP calculations as well as spectral and analytical data. The interactions of compounds (4-6) with HSA were studied by fluorescence spectroscopy, DLS, CD and molecular docking, under imitated physiological conditions...
June 14, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28623448/comparison-between-chemoselection-and-definitive-radiotherapy-in-patients-with-cervical-esophageal-squamous-cell-carcinoma
#11
Yusuke Nakata, Nobuhiro Hanai, Daisuke Nishikawa, Hidenori Suzuki, Yusuke Koide, Yujiro Fukuda, Motoo Nomura, Takeshi Kodaira, Takeshi Shimizu, Yasuhisa Hasegawa
BACKGROUD: Laryngeal preservation is an important consideration when treating cervical esophageal cancers (CECs) such as laryngeal cancer. The standard treatment for CEC allowing laryngeal preservation is chemoradiotherapy. However, in cases of laryngeal cancer, chemoselection has also been applied as a treatment strategy that promotes larynx preservation. This strategy involves assigning the appropriate radical treatment according to the primary tumor's response to induction chemotherapy...
June 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28623353/the-efficacy-and-toxicities-of-intensive-induction-chemotherapy-followed-by-concurrent-chemoradiotherapy-in-nasopharyngeal-carcinoma-patients-with-n3-disease
#12
Yingying Zhang, Mingqiu Chen, Cheng Chen, Lin Kong, Jiade J Lu, Benhua Xu
To assess the feasibility, efficacy and safety of 4 cycles of induction chemotherapy (ICT) followed by concurrent chemoradiotherapy (CRT) in nasopharyngeal carcinoma (NPC) patients with N3 disease. ICT consisting of paclitaxel (135 mg/m(2)) and nedaplatin (80 mg/m(2)) given every 3 weeks for 4 cycles followed by cisplatin-based CRT was planned. 22 patients completed 4 cycles of TP regimen ICT and the CRT according to the protocol. After 4 cycles of ICT, the ORR of the primary site was 100% (CR 22.7%, PR 77...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28615991/mir-34a-and-mir-206-act-as-novel-prognostic-and-therapy-biomarkers-in-cervical-cancer
#13
Ai-Hua Chen, Yu-E Qin, Wen-Fan Tang, Jing Tao, Hua-Mei Song, Manzhen Zuo
BACKGROUND: Recent evidence indicated that the aberrant expression of microRNA plays a crucial role in the development of cervical cancer. The overall shorter survival was strongly related to the abnormal expression of microRNA-34a (miR-34a) and microRNA-206 (miR-206), which target B cell lymphoma-2(Bcl2) and c-Met. Hepatocyte growth factor (HGF)/c-Met pathway is related to the occurrence, development and prognosis of cervical cancer, and c-Met is significantly overexpressed in cervical squamous cell carcinoma...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28614201/role-of-lymphovascular-invasion-in-pattern-c-invasive-endocervical-adenocarcinoma
#14
Andres A Roma, Kay J Park, Hao Xie, Andrea D De Vivar, Isabel Alvarado-Cabrero, Joanne K L Rutgers, Denise Barbuto, Elvio G Silva
Lymphovascular invasion (LVI) has been reported as an independent predictor of patient outcome in cervical carcinoma. However, not all studies support independent significance, especially in multivariable analyses. A risk stratification system recently introduced for endocervical adenocarcinoma was reported to better predict risk of lymph node (LN) metastasis. A subset of patients with tumors with pattern C features had LN metastasis and died of disease. In this study, we determined whether LVI had any additional significance in this subset of tumors...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28611495/antibacterial-anticancer-and-neuroprotective-activities-of-rare-actinobacteria-from-mangrove-forest-soils
#15
Adzzie-Shazleen Azman, Iekhsan Othman, Chee-Mun Fang, Kok-Gan Chan, Bey-Hing Goh, Learn-Han Lee
Mangrove is a complex ecosystem that contains diverse microbial communities, including rare actinobacteria with great potential to produce bioactive compounds. To date, bioactive compounds extracted from mangrove rare actinobacteria have demonstrated diverse biological activities. The discovery of three novel rare actinobacteria by polyphasic approach, namely Microbacterium mangrovi MUSC 115(T), Sinomonas humi MUSC 117(T) and Monashia flava MUSC 78(T) from mangrove soils at Tanjung Lumpur, Peninsular Malaysia have led to the screening on antibacterial, anticancer and neuroprotective activities...
June 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28608748/tympanic-membrane-and-ossicular-sparing-modified-lateral-temporal-bone-resection
#16
Yaser Ghavami, Yarah M Haidar, Marlon Maducdoc, Tjoson Tjoa, Omid Moshtaghi, Harrison W Lin, Hamid R Djalilian
A modified lateral temporal bone resection (mLTBR) is a unique technique that spares the tympanic membrane (TM) and ossicles in select patients with squamous cell carcinoma (SCCa). The records of 5 patients with SCCa of the temporal bone with negative frozen-section biopsy at the tympanic annulus were reviewed. The mean follow-up time for the patients was 29.2 months. One patient received postoperative radiation due to cervical nodal extracapsular spread. All patients were recurrence free as of the most recent follow-up (range, 8-50 months)...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28608737/preoperative-18-f-fdg-pet-ct-vs-contrast-enhanced-ct-to-identify-regional-nodal-metastasis-among-patients-with-head-and-neck-squamous-cell-carcinoma
#17
Joshua K Cho, Thomas J Ow, Andrew Y Lee, Richard V Smith, Nicolas F Schlecht, Bradley A Schiff, Andrew B Tassler, Juan Lin, Renee M Moadel, Ana Valdivia, Tony Abraham, Edwin Gulko, Matthew Neimark, Berrin Ustun, Jacqueline A Bello, Keivan Shifteh
Objective Our objective was to compare the accuracy of preoperative positron emission tomography (PET)/computed tomography (CT) and contrast-enhanced CT (CECT) in detecting cervical nodal metastases in patients treated with neck dissection and to scrutinize the ability of each modality to determine nodal stage. Study Design Case series with chart review. Setting Montefiore Medical Center, Bronx, New York. Subjects and Methods Patients who underwent neck dissection at our institution for primary treatment of head and neck squamous cell carcinoma (HNSCC) and had received preoperative PET/CT and CECT were included in this study...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28608677/block-copolymer-based-nanoparticles-for-theranostic-intervention-of-cervical-cancer-synthesis-pharmacokinetics-and-in-vitro-in-vivo-evaluation-in-hela-xenograft-models
#18
Shweta Dumoga, Yogesh Rai, Anant Narayan Bhatt, Anjani Kumar Tiwari, Surendra Singh, Anil Kumar Mishra, Dipti Kakkar
Polymer based nanoparticles have proven to be viable carriers of therapeutic agents. In this study we have developed nanoparticles (NPs) from polypeptide-polyethylene glycol based triblock and diblock copolymers. The synthesized block copolymers Poly (ethylene glycol)-b-Poly (glutamic acid)-b- Poly (ethylene glycol) (GEG) and Poly (ethylene glycol)-b-Poly (glutamic acid) (EG) conjugated with folic acid for targeting specificity (EGFA), have been used to encapsulate methotrexate (MTX) to form M-GEG and M-EGFA nanoparticles (NPs) aimed at passive and active targeting of cervical carcinoma...
June 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28607924/hipk2-overexpression-and-its-prognostic-role-in-human-papillomavirus-positive-tonsillar-squamous-cell-carcinoma
#19
Mi Jung Kwon, So Young Kang, Eun Sook Nam, Seong Jin Cho, Young-Soo Rho
Tonsillar squamous cell carcinomas (TSCCs) are the most common human papillomavirus- (HPV-) associated oropharyngeal cancers with poor prognosis. Homeodomain-interacting protein kinase 2 (HIPK2) is a central regulator of p53, which participates in apoptosis during the DNA damage response. HIPK2 is involved in HPV-associated uterine cervical and cutaneous carcinogenesis through its binding of HPV E6, thereby preventing apoptosis and contributing to tumor progression. However, its clinical and prognostic significance in TSCC remains unclear...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28607528/clinical-significance-and-prognostic-value-of-the-expression-of-lamp3-in-oral-squamous-cell-carcinoma
#20
Jun Lu, Hengcheng Ma, Shuijin Lian, Dan Huang, Min Lian, Ye Zhang, Jianfei Huang, Xingmei Feng
Recent studies demonstrated high expression of lysosome-associated membrane protein 3 (LAMP3) in a variety of malignancies including esophageal squamous cell carcinoma, gastrointestinal cancer, breast cancer, and cervical cancer and its involvement in several biological activities of tumor cells. However, the expression of LAMP3 and its value in oral squamous cell carcinoma (OSCC) remain unclear. In this study, we examined the expression of LAMP3 in OSCC tissue samples and investigated the relationship between LAMP3 and clinical characteristics of patients with OSCC...
2017: Disease Markers
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