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https://www.readbyqxmd.com/read/29040479/quality-of-life-following-esophagectomy-with-three-field-lymphadenectomy-for-carcinoma-focusing-on-its-relationship-to-vocal-cord-palsy
#1
M Baba, T Aikou, S Natsugoe, C Kusano, M Shimada, S Nakano, T Fukumoto, H Yoshinaka
To clarify the quality of life of patients who underwent esophagectomy for carcinoma by right thoracotomy, laparotomy and cervical anastomosis, 116 patients who were cancer free at the time of mailing a questionnaire were analyzed. A significant decrease in vital capacity for 3 years postoperatively, as well as in the percentage of ideal body weight, between 3 and 5 years were observed in 57 patients with three-field lymphadenectomy. Patients' quality of life undergoing three-field dissection was worse than those with less radical lymphadenectomy (59 cases) in terms of the performance status and difficulty in talking at 60 months or more postoperatively...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29036806/pritumumab-the-first-therapeutic-antibody-for-glioma-patients
#2
Ivan Babic, Elmar Nurmemmedov, Venkata M Yenugonda, Tiffany Juarez, Natsuko Nomura, Sandeep C Pingle, Mark C Glassy, Santosh Kesari
Immunotherapy is now at the forefront of cancer therapeutic development. Gliomas are a particularly aggressive form of brain cancer for which immunotherapy may hold promise. Pritumumab (also known in the literature as CLNH11, CLN-IgG, and ACA-11) was the first monoclonal antibody tested in cancer patients. Pritumumab is a natural human monoclonal antibody developed from a B lymphocyte isolated from a regional draining lymph node of a patient with cervical carcinoma. The antibody binds ecto-domain vimentin on the surface of cancer cells...
September 1, 2017: Human Antibodies
https://www.readbyqxmd.com/read/29034992/combined-prognostic-value-of-pretreatment-anemia-and-cervical-node-necrosis-in-patients-with-nasopharyngeal-carcinoma-receiving-intensity-modulated-radiotherapy-a-large-scale-retrospective-study
#3
Lu-Lu Zhang, Guan-Qun Zhou, Yi-Yang Li, Ling-Long Tang, Yan-Ping Mao, Ai-Hua Lin, Jun Ma, Zhen-Yu Qi, Ying Sun
This study investigated the combined prognostic value of pretreatment anemia and cervical node necrosis (CNN) in patients with nasopharyngeal carcinoma (NPC). Retrospective review of 1302 patients with newly diagnosed nonmetastatic NPC treated with intensity-modulated radiotherapy (IMRT) ± chemotherapy. Patients were classified into four groups according to anemia and CNN status. Survival was compared using the log-rank test. Independent prognostic factors were identified using the Cox proportional hazards model...
October 16, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29034552/cervical-carcinomas-with-a-micropapillary-component-a-clinicopathological-study-of-8-cases
#4
Colin J R Stewart, M H E Koay, Connull Leslie, Nathan Acott, Yee C Leung
AIMS: Micropapillary carcinomas, or carcinomas with a micropapillary component, are well-recognised in the breast and other anatomical sites. However, they have seldom been described in the cervix. In this report we present a clinicopathological analysis of eight cervical tumours that showed at least a focal (≥5%) component of micropapillary carcinoma. METHODS AND RESULTS: The study group comprised eight cervical carcinomas (4 adenocarcinomas and 4 adenosquamous carcinomas) with a micropapillary component...
October 16, 2017: Histopathology
https://www.readbyqxmd.com/read/29033672/role-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-the-evaluation-of-head-and-neck-carcinoma
#5
REVIEW
Moheieldin M Abouzied, Ahmed Fathala, Abdulaziz Alsugair, Ahmad I Al Muhaideb, Mohammed H Al Qahtani
Fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET-CT) has been playing a pivotal role in tumor imaging for the past 20 years. Head and neck (HN) cancers are a good example that can illustrate such unique role of FDG imaging contributing to the patient's management. In this review article, we will describe the normal physiological distribution of FDG within HN structures focusing on its limitations and pitfalls. In addition, we will be also describing its role in the initial staging and restaging of the disease, particularly with regard to therapy response assessment...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033443/signet-ring-cell-carcinoma-of-unknown-primary-origin-detected-incidentally-by-lymph-node-purification-for-thyroid-carcinoma
#6
Hideo Handa, Daisuke Gomi, Toshirou Fukushima, Takashi Kobayashi, Nodoka Sekiguchi, Akiyuki Sakamoto, Yoshiko Tsukahara, Hirohide Matsushita, Shigeru Sasaki, Keiko Mamiya, Tomonobu Koizumi, Takashi Ichiyama
A 63-year-old woman underwent thyroidectomy for papillary thyroid adenocarcinoma and cervical lymph node resection. Pathological analyses revealed the presence of signet cell carcinoma in a resected lymph node, which were apparently different from the pathological findings of thyroid carcinoma. No evidence of a primary tumor could be found elsewhere despite detailed examinations, including esophagogastroduodenoscopy, colonoscopy, capsule endoscopy, CT scan, and fluorodeoxyglucose-positron emission tomography...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29033003/clinicopathological-parameters-affecting-nodal-yields-in-patients-with-oral-squamous-cell-carcinoma-receiving-selective-neck-dissection
#7
Ali-Farid Safi, Martin Kauke, Andrea Grandoch, Hans-Joachim Nickenig, Uta Drebber, Joachim Zöller, Matthias Kreppel
INTRODUCTION: Nodal yield has been demonstrated as a very promising marker for the prognostic outcome of patients with oral squamous cell carcinoma. However, studies on the importance of clinicopathological factors affecting the number of resected lymph nodes are rare, especially for patients without pathologically proven cervical lymph nodes. MATERIAL AND METHODS: Retrospective chart review of 264 patients with treatment naive oral squamous cell carcinoma and histopathologically proven negative cervical lymph node status, who received selective neck dissection of levels I-III/IV...
September 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29032160/multimodal-treatment-including-hysterectomy-improves-survival-in-patients-with-locally-advanced-cervical-cancer-a-population-based-propensity-score-matched-analysis
#8
San-Gang Wu, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, Juan Zhou
BACKGROUND: To evaluate the therapeutic value of multimodal treatment including hysterectomy in locally advanced cervical squamous cell carcinoma (SCC). METHODS: We retrospectively reviewed patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB-III cervical SCC between 2000 and 2013 using the Surveillance, Epidemiology, and End Results (SEER) program. Propensity score-matching was used to balance baseline characteristics of included patients...
October 12, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29031556/corrigendum-to-long-term-results-of-a-phase-ii-study-of-gemcitabine-and-cisplatin-chemotherapy-combined-with-intensity-modulated-radiotherapy-in-locoregionally-advanced-nasopharyngeal-carcinoma-oral-oncol-73-2017-118-123
#9
Mingyao Wu, Dan Ou, Xiayun He, Chaosu Hu
OBJECTIVES: To evaluate long-term results of a phase II study of induction and adjuvant gemcitabine and cisplatin (GP) chemotherapy with intensity-modulated radiotherapy (IMRT) in locoregionally advanced nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS: One hundred and twelve patients (Stage III: 65, IVA-B: 47) with locoregionally advanced NPC were enrolled in this study. All patients received induction chemotherapy consisting of 1000 mg/m(2) gemcitabine on day 1 and 8, and cisplatin 25 mg/m(2) on day 1-3, every 3 weeks for 2 cycles...
October 11, 2017: Oral Oncology
https://www.readbyqxmd.com/read/29031368/chapter-6-non-squamous-cell-causes-of-cervical-lymphadenopathy
#10
Mohit Agarwal, Seyed Ali Nabavizadeh, Suyash Mohan
Cervical lymphadenopathy is a common indication for imaging evaluation of the neck. Besides metastatic squamous cell carcinoma of the head and neck, cervical lymphadenopathy can be due to many causes, with simple reactive lymphadenopathy on one end of the spectrum and malignant lymphadenopathy due to a distant infraclavicular primary, on the other end. A systematic approach to the cause of cervical lymphadenopathy, which includes pattern of lymph node enlargement, lymph node characteristics, systemic symptoms, and extranodal abnormalities, can be very useful in arriving at the correct diagnosis...
October 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29031364/chapter-2-squamous-cell-carcinoma-of-the-head-and-neck-imaging-evaluation-of-regional-lymph-nodes-and-implications-for-management
#11
Hillary R Kelly, Hugh D Curtin
The presence of cervical lymph node metastases is a major prognostic factor in squamous cell carcinoma of the head and neck. The presence of a solitary ipsilateral metastatic lymph node reduces expected survival by almost 50%, and the presence of regional metastatic nodes at the time of presentation is the strongest predictor of recurrence or the development of distant metastases or both. Therefore, accurate identification of metastatic cervical lymph nodes is essential for staging and treatment planning. Pretreatment imaging is important for identifying clinically occult pathologic nodes as well as delineating nodal size and morphologic characteristics used in staging...
October 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29029517/prognostic-value-of-hpv-dna-status-in-cervical-cancer-before-treatment-a-systematic-review-and-meta-analysis
#12
Ping Li, Yue Tan, Li-Xia Zhu, Li-Na Zhou, Ping Zeng, Qin Liu, Min-Bin Chen, Ye Tian
BACKGROUND: Human papillomavirus (HPV), has been recognized as an vital preliminary event in the oncogenesis of cervical cancer. But the prognostic value is not well defined, because of past studies showing conflicting results. So we conducted this meta-analysis to evaluate whether HPV DNA status was associated with prognosis in cervical cancer. MATERIALS AND METHODS: A total of 17 previously published eligible studies including 2,838 cases were identified and included in this meta-analysis...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027399/early-stage-node-negative-cervical-adenocarcinoma-and-squamous-cell-carcinoma-show-similar-survival-outcomes-after-hysterectomy-a-population-based-study
#13
San Gang Wu, Jia Yuan Sun, Zhen Yu He, Qiong Hua Chen, Juan Zhou
OBJECTIVE: To investigate the clinicopathological features and outcomes between node-negative, early-stage cervical squamous cell carcinoma (SCC) and adenocarcinoma (AC) after hysterectomy. METHODS: Patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stages I-IIA cervical SCC and AC between 1988 and 2013 were retrospectively reviewed using the Surveillance, Epidemiology, and End Results database. We used propensity score-matching to balance patient baseline characteristics...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027397/comparing-treatment-outcomes-of-stage-iiib-cervical-cancer-patients-between-those-with-and-without-lower-third-of-vaginal-invasion
#14
Kanyarat Katanyoo
OBJECTIVE: To evaluate treatment outcomes between stage IIIB cervical cancer with and without lower third of vaginal invasion (LTI) in terms of response to treatment and overall survival (OS). METHODS: Matching one patient with LTI for 2 patients without LTI who had completed treatment between 1995 and 2012 were conducted by using treatment modalities (radiation therapy [RT] alone vs. concurrent chemoradiation therapy [CCRT]) and tumor histology (squamous cell carcinoma [SCC] vs...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027393/down-regulated-serum-microrna-101-is-associated-with-aggressive-progression-and-poor-prognosis-of-cervical-cancer
#15
Wei Jiang, Jia Jia Pan, Ying Hui Deng, Mei Rong Liang, Li Hua Yao
OBJECTIVE: MicroRNAs (miRNAs) play a vital role in pathogenesis and progression of many cancers, including cervical cancer. However, importance of serum level of miR-101 in cervical cancer has rarely been studied. In the present study, clinical significance and prognostic value of serum miR-101 for cervical cancer was investigated. METHODS: Association between miR-101 level in cervical cancer tissues and prognosis of patients was analyzed by using data retrieved from The Cancer Genome Atlas (TCGA) database, which was followed with our clinical study in which miR-101 serum level comparison between cervical cancer patients and healthy controls was conducted by real-time quantitative polymerase chain reaction (PCR)...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29025277/clinical-analysis-of-recurrence-patterns-in-patients-with-nasopharyngeal-carcinoma-treated-with-intensity-modulated-radiotherapy
#16
Lijun Wang, Yesong Guo, Jianhua Xu, Zhenzhang Chen, Xuesong Jiang, Lanfang Zhang, Shengfu Huang, Xia He, Yiqin Zhang
OBJECTIVE: To evaluate the characteristics and risk factors for locoregional recurrence in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT). METHODS: The clinical diagnosis and treatment data of 195 patients with NPC treated with IMRT from March 2005 to May 2010 (including 9, 24, 70, and 92 cases of stage I, II, III, and IV disease, respectively, according to the 7th edition American Joint Committee on Cancer staging criteria) were retrospectively analyzed...
October 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29024178/familial-clustering-of-oropharyngeal-squamous-cell-carcinoma-in-the-utah-population
#17
Marcus M Monroe, Mia Hashibe, Quinn Orb, Jeremiah Alt, Luke Buchmann, Jason Hunt, Lisa A Cannon-Albright
BACKGROUND: The main purpose of the current study was to define the familial aggregation of oropharyngeal squamous cell carcinoma (SCC) and risk to relatives of patients with oropharyngeal SCC. METHODS: We conducted a retrospective study utilizing linked population-based genealogy and state cancer registry databases between 1966 and 2012. Relative risks for oropharyngeal SCC and other malignancies among patients with oropharyngeal SCC and their relatives were estimated...
October 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/29022861/molecular-characterization-prevalence-and-clinical-relevance-of-phodopus-sungorus-papillomavirus-type-1-psupv1-naturally-infecting-siberian-hamsters-phodopus-sungorus
#18
Boštjan J Kocjan, Lea Hošnjak, Joško Račnik, Marko Zadravec, Nejc Bakovnik, Blaž Cigler, Monique Ummelen, Anton H N Hopman, Nina Gale, Tanja Švara, Mitja Gombač, Mario Poljak
Phodopus sungorus papillomavirus type 1 (PsuPV1), naturally infecting Siberian hamsters (Phodopus sungorus) and clustering in the genus Pipapillomavirus (Pi-PV), is only the second PV type isolated from the subfamily of hamsters. In silico analysis of three independent complete viral genomes obtained from cervical adenocarcinoma, oral squamous cell carcinoma and normal oral mucosa revealed that PsuPV1 encodes characteristic viral proteins (E1, E2, E4, E6, E7, L1 and L2) with conserved functional domains and a highly conserved non-coding region...
October 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29022644/assessment-of-risk-factors-in-metastatic-recurrent-tall-cell-variant-of-papillary-thyroid-carcinoma
#19
Kursat Okuyucu, Engin Alagoz, Semra Ince, Nuri Arslan
INTRODUCTION: Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor. A great majority of the cases live a disease-free life with quite favorable prognosis. There are lots of variants of PTC and a few of them exhibit aggressive behaviour. Typical example is the tall cell variant (TCV). Patients experience a greater incidence of recurrence, nodal and extranodal metastases, tumor associated mortality than other variants of PTC. Studies related to TCV almost always compared it with its patient population of PTC according to risk factors and clinicopathologic features...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022484/prognostic-implication-of-simultaneous-anemia-and-lymphopenia-during-concurrent-chemoradiotherapy-in-cervical-squamous-cell-carcinoma
#20
Oyeon Cho, Mison Chun, Young-Taek Oh, O Kyu Noh, Suk-Joon Chang, Hee-Sug Ryu, Eun Ju Lee
Radioresistance often leads to poor survival in concurrent chemoradiotherapy-treated cervical squamous cell carcinoma, and reliable biomarkers can improve prognosis. We compared the prognostic potential of hemoglobin, absolute neutrophil count, and absolute lymphocyte count with that of squamous cell carcinoma antigen in concurrent chemoradiotherapy-treated squamous cell carcinoma. We analyzed 152 patients with concurrent chemoradiotherapy and high-dose-rate intracavitary brachytherapy-treated cervical squamous cell carcinoma...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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