keyword
MENU ▼
Read by QxMD icon Read
search

Ewings sarcoma

keyword
https://www.readbyqxmd.com/read/29776413/the-cxcr4-antagonist-plerixafor-amd3100-promotes-proliferation-of-ewing-sarcoma-cell-lines-in-vitro-and-activates-receptor-tyrosine-kinase-signaling
#1
Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen, Jenny Potratz
BACKGROUND: The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine - receptor interaction between neoplastic cells and their microenvironment in tumor progression and metastasis. Here, we investigated plerixafor for anti-cancer activity in Ewing sarcoma, a rare and aggressive cancer of bone and soft tissues. METHODS: We used a variety of methods such as cell viability and migration assays, flow cytometry, phospho-tyrosine arrays and western blotting to determine plerixafor effects on five characterized Ewing sarcoma cell lines and a low-passage culture in vitro...
May 18, 2018: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/29761244/copper-tolfenamic-acid-evaluation-of-stability-and-anti-cancer-activity
#2
Myrna Hurtado, Umesh T Sankpal, Jaya Chhabra, Deondra T Brown, Rajasekhar Maram, Rafid Patel, Raj K Gurung, Jerry Simecka, Alvin A Holder, Riyaz Basha
The non-steroidal anti-inflammatory drug, Tolfenamic acid (TA) acts as an anti-cancer agent in several adult and pediatric cancer models. Copper (Cu) is an important element with multiple biological functions and has gained interest in medical applications. Recently, [Cu(TA)2 (bpy)] (Cu-TA) has been synthesized in order to enhance therapeutic activity. In this study, we synthesized Cu-TA using an established method, characterized it by UV visible spectroscopy and Fourier-transform infrared spectroscopy (FTIR), and tested its anti-cancer activity using twelve cell lines representing various cancers, such as Ewing sarcoma, glioblastoma, medulloblastoma, neuroblastoma, pancreatic and prostate...
May 15, 2018: Investigational New Drugs
https://www.readbyqxmd.com/read/29756246/ewing-sarcoma-of-the-head-and-neck-the-mayo-clinic-experience
#3
Michael D Olson, Kathryn M Van Abel, Rebecca N Wehrs, Joaquin J Garcia, Eric J Moore
BACKGROUND: Treatment options of Ewing sarcoma of the head and neck include surgery, radiotherapy (RT), and chemoradiotherapy. However, local control can be challenging. METHODS: We conducted a retrospective review of all patients with head and neck Ewing sarcoma treated from 1972 to 2015 at a single tertiary care hospital. RESULTS: Seventeen patients met criteria (median 21 years, range 5-58 years; 5 women). Mean follow-up was 10.4 years (range 2...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29755686/transcriptome-based-individualized-therapy-of-refractory-pediatric-sarcomas-feasibility-tolerability-and-efficacy
#4
Bushra Weidenbusch, Günther H S Richter, Marie Sophie Kesper, Monika Guggemoos, Katja Gall, Carolin Prexler, Ilya Kazantsev, Alexandra Sipol, Lars Lindner, Michaela Nathrath, Olaf Witt, Katja Specht, Frigga Beitinger, Carolin Knebel, Stuart Hosie, Rüdiger von Eisenhardt-Rothe, Wilko Weichert, Irene Teichert-von Luettichau, Stefan Burdach
Survival rates of pediatric sarcoma patients stagnated during the last two decades, especially in adolescents and young adults (AYAs). Targeted therapies offer new options in refractory cases. Gene expression profiling provides a robust method to characterize the transcriptome of each patient's tumor and guide the choice of therapy. Twenty patients with refractory pediatric sarcomas (age 8-35 years) were assessed with array profiling: ten had Ewing sarcoma, five osteosarcoma, and five soft tissue sarcoma. Overexpressed genes and deregulated pathways were identified as actionable targets and an individualized combination of targeted therapies was recommended...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29752484/surveillance-mri-for-the-detection-of-locally-recurrent-ewing-sarcoma-seems-futile
#5
Ömer Kasalak, Amelie Dammann, Hugo J A Adams, Jelle Overbosch, Rudi A J O Dierckx, Paul C Jutte, Thomas C Kwee
PURPOSE: To determine the frequency of locally recurrent Ewing sarcoma on surveillance MRI and the outcome of these patients. MATERIALS AND METHODS: This retrospective single-center study included all patients with newly diagnosed Ewing sarcoma who underwent surveillance MRI of the primary tumor location after primary treatment between 1997 and 2016. RESULTS: Thirty-two patients underwent a total of 176 local surveillance MRI scans, yielding an average of 5...
May 11, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29750397/fdg-pet-ct-in-the-evaluation-of-primary-and-secondary-pancreatic-malignancies
#6
Casey E Bohl, Sara M Federico, Giles W Robinson, Armita Bahrami, Barry L Shulkin
PURPOSE: Primary pancreatic carcinoma and pancreatic metastases are rare in the pediatric population. Pancreatoblastoma is the most common pancreatic malignant tumor in young children and solid-pseudopapillary tumor in teenagers. Pancreatic adenocarcinoma is extremely rare under the age of 40 and is usually associated with underlying genetic abnormalities. Secondary malignancies of the pancreas occur more frequently than primary pancreatic malignancies in children and are most commonly seen with non-Hodgkin lymphomas (NHL) and mesenchymal sarcomas...
May 11, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29742917/diagnostic-value-of-mri-signs-in-differentiating-ewing-sarcoma-from-osteomyelitis
#7
Ömer Kasalak, Jelle Overbosch, Hugo Ja Adams, Amelie Dammann, Rudi Ajo Dierckx, Paul C Jutte, Thomas C Kwee
Background The value of magnetic resonance imaging (MRI) signs in differentiating Ewing sarcoma from osteomyelitis has not be thoroughly investigated. Purpose To investigate the value of various MRI signs in differentiating Ewing sarcoma from osteomyelitis. Material and Methods Forty-one patients who underwent MRI because of a bone lesion of unknown nature with a differential diagnosis that included both Ewing sarcoma and osteomyelitis were included. Two observers assessed several MRI signs, including the transition zone of the bone lesion, the presence of a soft-tissue mass, intramedullary and extramedullary fat globules, and the penumbra sign...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29737103/-therapeutic-effect-of-uncemented-allograft-prosthetic-composite-for-the-reconstruction-of-tumorous-bone-defect
#8
Yan-Ling Wang, Li Min, Hong Duan, Yong Zhou, Wei-Li Zhang, Rui Shi, Yi Luo, Chong-Qi Tu
OBJECTIVE: To investigate the surgical techniques and mid-term efficacy of reconstruction for proximal femur with allograft-prosthetic composite (APC) . METHODS: Fifteen patients who underwent uncemented APC reconstruction of proximal femur after bone tumor resection were retrospectively evaluated. Image and physical examinations were taken on the 1st,3rd,6th,9th and 12th month after surgery and every 6 months thereafter to assess union condition,greater trochanteric bone absorption and myodynamia of abductors...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29732544/ewing-s-sarcoma-metastatic-to-skin-a-case-report-and-review-of-the-literature
#9
Alejandra Toquica, Xavier Rueda, Sergio Cervera, Adriana Reina, Carolina Pozzobon, Samuel D Morales, Rafael Parra-Medina
No abstract text is available yet for this article.
May 6, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29731799/beware-of-bone-marrow-incidental-detection-and-primary-diagnosis-of-solid-tumours-in-bone-marrow-aspiration-and-biopsies-a-study-of-22-cases
#10
Ruchita Tyagi, Aminder Singh, Bhavna Garg, Neena Sood
Background & objective: Introduction: First detection of any solid tumour as metastatic deposits in bone marrow directs clinicians to start searching for the primary tumour. Detection of bone marrow metastasis determines the stage of the malignancy, prognosis, mode of treatment, chemotherapeutic response and follow-up in case of relapse. The aim of the current study was to analyse the clinico-haematological presentation and morphological pattern of infiltration of solid tumours detected first as metastatic deposits on bone marrow examination...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29731738/insulin-like-growth-factor-2-mrna-binding-protein-3-influences-sensitivity-to-anti-igf-system-agents-through-the-translational-regulation-of-igf1r
#11
Caterina Mancarella, Michela Pasello, Maria Cristina Manara, Lisa Toracchio, Evelina Fiorenza Sciandra, Piero Picci, Katia Scotlandi
Insulin-like growth factor 2 (IGF2) mRNA-binding protein 3 (IGF2BP3) is an oncofetal protein that binds RNA, thereby influencing the fate of target transcripts. IGF2BP3 is synthesized de novo in cancer, where it promotes proliferation, drug resistance, and metastasis via both IGF2-dependent and IGF2-independent mechanisms. Ewing sarcoma (ES) is a rare bone and soft tissue tumor in which the IGF system plays a pivotal role. This study aimed to investigate the effect of IGF2BP3 on the regulation of the IGF system in ES...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29729469/primary-intracranial-ppnet-ewing-s-sarcoma-diagnosis-management-and-prognostic-factors-dilemma-a-systematic-review-of-the-literature
#12
REVIEW
Abad Cherif El Asri, Mohamed Benzagmout, Khalid Chakour, Mohamed Faiz Chaoui, Jawad Laaguili, Chahdi Hafsa, Miloudi Gazzaz, Brahim El Mostarchid
BACKGROUND: Ewing's sarcoma (ES) is a malignant bone tumor that is most commonly observed in the long bones, the pelvis and in the chest. Primary intracranial localization is extremely rare. OBJECTIVE: In the aim of identifying the prognostic factors of this rare localization; we have conducted a systematic review of the literature for patients with primary intracranial pPNET/ES. METHODS: A complete MEDLINE search was undertaken for all articles reporting data for primary intracranaial pPNET/ES...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29729453/the-slam-family-receptors-potential-therapeutic-targets-for-inflammatory-and-autoimmune-diseases
#13
REVIEW
Matthew A Dragovich, Adam Mor
The signaling lymphocytic activation molecule (SLAM) family is comprised of nine distinct receptors (SLAMF1 through SLAMF9) that are expressed on hematopoietic cells. All of these receptors, with the exception of SLAMF4, are homotypic by nature as downstream signaling occurs when hematopoietic cells that express the same SLAM receptor interact. The SLAM family receptor function is largely controlled via SLAM associated protein (SAP) family adaptors. The SAP family adaptors consist of SAP, Ewing sarcoma associated transcript (EAT)-2, and EAT-2-related transducer (ERT)...
May 3, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29719113/a-phase-1-study-of-eribulin-mesylate-e7389-a-novel-microtubule-targeting-chemotherapeutic-agent-in-children-with-refractory-or-recurrent-solid-tumors-a-children-s-oncology-group-phase-1-consortium-study-advl1314
#14
Eric S Schafer, Rachel E Rau, Stacey Berg, Xiaowei Liu, Charles G Minard, David D'Adamo, Rachael Scott, Larisa Reyderman, Gresel Martinez, Sandhya Devarajan, Joel M Reid, Elizabeth Fox, Brenda J Weigel, Susan M Blaney
BACKGROUND: Eribulin mesylate is a novel anticancer agent that inhibits microtubule growth, without effects on shortening, and promotes nonproductive tubulin aggregate formation. We performed a phase 1 trial to determine the dose-limiting toxicities (DLTs), maximum tolerated or recommended phase 2 dose (MTD/RP2D), and pharmacokinetics (PK) of eribulin in children with refractory or recurrent solid (excluding central nervous system) tumors. METHODS: Eribulin was administered intravenously on days 1 and 8 in 21-day cycles...
May 2, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29716532/limb-saving-surgery-for-ewing-s-sarcoma-of-the-distal-tibia-a-case-report
#15
Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Yoshinobu Oka, Toshikazu Kubo
BACKGROUND: Ewing's sarcoma is a primary malignant tumor of bone occurring mostly in childhood. Few effective reconstruction techniques are available after wide resection of Ewing's sarcoma at the distal end of the tibia. Reconstruction after wide resection is especially difficult in children, as it is necessary to consider the growth and activity of the lower limbs. CASE PRESENTATION: A 12-year-old Japanese boy had presented with right lower leg pain at age 8 years...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29715573/primary-ewing-sarcoma-of-frontotemporal-bone-in-a-geriatric-patient-case-report
#16
Seckin Aydin, Odhan Yuksel, Rahime Tanritanir, Aysegul Esen Aydin, Suat Erol Celik
Ewing sarcoma is a rare primary malignant bone tumor which mainly effects children and adolescents. Calvarial bone involvement and its appearance in elder patients are extremely rare. We presented a 68 years old female patient with headache and right frontotemporal swelling. Imaging studies showed a right frontotemporal mass expanding to Sylvian fissure. The patient underwent total resection of the mass and pathological evaluation ensured the diagnosis of primary Ewing sarcoma. Patient had adjuvant radio- and chemotherapy after surgery...
April 28, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29714464/insulin-like-growth-factor-1-receptor-expression-in-pediatric-tumors-a-comparative-immunohistochemical-study
#17
Resul Karakuş, Esra Karakuş, Suna Emir, Ayper Kaçar, Derya Özyörük
Background/aim: Insulin-like growth factor-1 receptor (IGF-1R) is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. It is differentially expressed in various types of tumors. We aimed to determine the expression of IGF- 1R in different pediatric tumors and to shed light on possible new indications of anti-IGF-1R treatment approaches. Materials and methods: A total of 147 specimens were analyzed according to their expression of IGF-1R. Specimens included those from rhabdomyosarcomas, Wilms tumors, Ewing sarcoma/primitive neuroectodermal tumors, peripheral neuroblastic tumors, acute lymphoblastic lymphoma, Hodgkin lymphoma, Burkitt lymphoma, retinoblastoma, pleuropulmonary blastoma, Langerhans cell histiocytosis, endodermal sinus tumors (ESTs), and myeloid sarcoma...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29703820/insulin-like-growth-factor-2-mrna-binding-protein-3-is-a-novel-post-transcriptional-regulator-of-ewing-sarcoma-malignancy
#18
Caterina Mancarella, Michela Pasello, Selena Ventura, Andrea Grilli, Linda Calzolari, Lisa Toracchio, Pier Luigi Lollini, Davide Maria Donati, Piero Picci, Stefano Ferrari, Katia Scotlandi
PURPOSE: Large-scale sequencing studies have indicated that besides genomic alterations, the post-transcriptional regulation of gene expression or epigenetic mechanisms largely influences the clinical behavior of Ewing sarcoma (ES). We investigated the significance of the RNA-binding protein IGF2BP3 in the regulation of ES aggressiveness. EXPERIMENTAL DESIGN:  Explorative study was performed in 15 patients with localized ES using RNAseq. Next, 128 patients with localized ES were divided into two cohorts...
April 27, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29693796/a-phase-1-study-of-cabozantinib-in-children-and-adolescents-with-recurrent-or-refractory-solid-tumors-including-cns-tumors-trial-advl1211-a-report-from-the-children-s-oncology-group
#19
Meredith K Chuk, Brigitte C Widemann, Charles G Minard, Xiaowei Liu, AeRang Kim, Melanie Brooke Bernhardt, Rachel A Kudgus, Joel M Reid, Stephan D Voss, Susan Blaney, Elizabeth Fox, Brenda J Weigel
BACKGROUND: We conducted a phase 1 trial to determine the maximum tolerated dose (MTD), toxicity profile, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary activity of cabozantinib in children with refractory or relapsed solid tumors. METHODS: Patients received cabozantinib tablets on a continuous dosing schedule in a rolling-six escalating phase 1 trial design. PK and PD studies were performed. RESULTS: Forty-one patients, median (range) age 13 (4-18) years, received cabozantinib to achieve a weekly cumulative dose equivalent to 30 (n = 6), 40 (n = 23)...
April 25, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29682023/extraosseous-primary-intracranial-ewing-sarcoma-peripheral-primitive-neuroectodermal-tumor-series-of-seven-cases-and-review-of-literature
#20
Amit Kumar Singh, Arun Kumar Srivastava, Lily Pal, Jayesh Sardhara, Rajan Yadav, Shalini Singh, Kamlesh Singh Bhaisora, Kuntal Kanti Das, Anant Mehrotra, Rabi Narayan Sahu, Awadhesh Kumar Jaiswal, Sanjay Behari
Background: The Ewing sarcoma peripheral PNET (ES-pPNET) is very rare small round cell tumour that involves the CNS as either a primary dural neoplasm or by direct extension from contiguous bone or soft tissue. Materials and Methods: Biopsy proven cases of intracranial ES/pPNET with orbital involvement operated during Jan 2010-Jan 2014 were retrospectively included and their clinical data, operative and histological findings were reviewed from institutional oncology register...
April 2018: Asian Journal of Neurosurgery
keyword
keyword
30460
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"