S Chen, Bertolini A, G Koukou, E M Wendel, C Thiels, M Baumann, C Lechner, A Blaschek, A Della Marina, G Classen, B Stüve, B Kauffmann, T Kapanci, B Mayer, M Otto, K Rostásy
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the CNS. An intrathecal IgM synthesis is associated with a more rapid progression of MS and the intrathecal immune response to measles -, rubella -and varicella zoster virus (MRZR) which, if present, increases the likelihood of a diagnosis of MS in adults. OBJECTIVE: To evaluate the frequency of an intrathecal IgM synthesis and MRZR in children with MS. MethodsChildren with MS and a data set including clinical and treatment history, MRI at onset, in addition to a CSF analysis, and determination of antibody index (AI) of measles, rubella, and zoster antibodies, were eligible...
April 16, 2024: European Journal of Paediatric Neurology: EJPN