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https://www.readbyqxmd.com/read/29441496/differences-in-incremental-cost-effectiveness-ratios-for-common-versus-rare-conditions-a-case-from-oncology
#1
Kavisha Jayasundara, Murray Krahn, Muhammad Mamdani, Jeffrey S Hoch, Paul Grootendorst
BACKGROUND: Incremental cost-effectiveness ratios (ICERs) are used to assess the value for money of new drugs. Many believe that ICERs for drugs that treat rare diseases are much higher than those of common drugs. Our objective was to compare the proportion of ICERs that are cost effective for rare and common cancers. METHODS: We used the Tufts Medical Center Cost-Effectiveness Analysis (CEA) Registry to identify cost-effectiveness studies of pharmaceutical interventions for cancers...
September 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29440213/does-industry-sponsored-education-foster-overdiagnosis-and-overtreatment-of-depression-osteoporosis-and-over-active-bladder-syndrome-an-australian-cohort-study
#2
Barbara Mintzes, Swestika Swandari, Alice Fabbri, Quinn Grundy, Ray Moynihan, Lisa Bero
OBJECTIVES: To investigate patterns of industry-sponsored educational events that focus on specific health conditions for which there are concerns about overdiagnosis and overtreatment. DESIGN AND SETTING: This retrospective cohort study examines publicly reported industry-sponsored events in Australia from October 2011 to September 2015 for three conditions potentially subject to overdiagnosis and overtreatment: depression, osteoporosis and overactive bladder. We used a database of transparency reports to identify events with a focus on depression, osteoporosis and overactive bladder and compared these with other sponsored events...
February 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29370436/predictors-of-placebo-response-in-pharmacological-clinical-trials-of-negative-symptoms-in-schizophrenia-a-meta-regression-analysis
#3
David Fraguas, Covadonga M Díaz-Caneja, Laura Pina-Camacho, Daniel Umbricht, Celso Arango
We conducted a meta-regression analysis of all double-blind, randomized, placebo-controlled clinical trials (DBRCTs) reporting effects of drug and placebo on negative symptoms in people with stable schizophrenia and predominant or prominent negative symptoms to assess predictors of placebo response in these individuals. We used Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for systematic reviews and meta-analyses to conduct a systematic literature search to identify DBRCTs assessing treatment efficacy on negative symptoms, as primary outcome, in patients with stable schizophrenia and predominant or prominent negative symptoms...
January 19, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29353296/the-urban-environment-of-alcohol-a-study-on-the-availability-promotion-and-visibility-of-its-use-in-the-neighborhoods-of-barcelona
#4
Joan R Villalbí, Albert Espelt, Xisca Sureda, Marina Bosque-Prous, Ester Teixidó-Compañó, Susanna Puigcorbé, Manuel Franco, M Teresa Brugal
INTRODUCTION: This paper describes the presence of alcohol in the public space, assessing establishments that offer it, its advertising, and signs of consumption, as factors that may influence its consumption. METHOD: Descriptive observational study based on cluster sampling with two-step selection. Results are described, and the spatial association between variables is assessed. RESULTS: In the 20 census tracts studied, 306 premises were identified that offered alcoholic beverages: 204 were on-premises and 102 were off-premises, mainly supermarkets and food retail stores...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29282031/competing-with-big-business-a-randomised-experiment-testing-the-effects-of-messages-to-promote-alcohol-and-sugary-drink-control-policy
#5
Maree Scully, Emily Brennan, Sarah Durkin, Helen Dixon, Melanie Wakefield, Colleen L Barry, Jeff Niederdeppe
BACKGROUND: Evidence-based policies encouraging healthy behaviours are often strongly opposed by well-funded industry groups. As public support is crucial for policy change, public health advocates need to be equipped with strategies to offset the impact of anti-policy messages. In this study, we aimed to investigate the effectiveness of theory-based public health advocacy messages in generating public support for sugary drink/alcohol policies (increased taxes; sport sponsorship bans) and improving resistance to subsequent anti-policy messages typical of the sugary drink/alcohol industry...
December 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29241881/ispor-code-of-ethics-2017-4th-edition
#6
Jessica Santos, Francis Palumbo, Elizabeth Molsen-David, Richard J Willke, Louise Binder, Michael Drummond, Anita Ho, William D Marder, Louise Parmenter, Gurmit Sandhu, Asrul A Shafie, David Thompson
As the leading health economics and outcomes research (HEOR) professional society, ISPOR has a responsibility to establish a uniform, harmonized international code for ethical conduct. ISPOR has updated its 2008 Code of Ethics to reflect the current research environment. This code addresses what is acceptable and unacceptable in research, from inception to the dissemination of its results. There are nine chapters: 1 - Introduction; 2 - Ethical Principles respect, beneficence and justice with reference to a non-exhaustive compilation of international, regional, and country-specific guidelines and standards; 3 - Scope HEOR definitions and how HEOR and the Code relate to other research fields; 4 - Research Design Considerations primary and secondary data related issues, e...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29151109/reporting-of-randomized-trials-in-common-cancers-in-the-lay-media
#7
Domen Ribnikar, Hadar Goldvaser, Alberto Ocana, Arnoud J Templeton, Bostjan Seruga, Eitan Amir
BACKGROUND: Limited data exist about the role of the lay media in the dissemination of results of randomized controlled trials (RCTs) in common cancers. METHODS: Completed phase III RCTs evaluating new drugs in common cancers between January 2005 and October 2016 were identified from ClinicalTrials.gov. Lay media reporting was identified by searching LexisNexis Academic. Scientific reporting was defined as presentation at an academic conference or publication in full...
November 18, 2017: Oncology
https://www.readbyqxmd.com/read/29078815/study-protocol-incentives-for-increased-access-to-comprehensive-family-planning-for-urban-youth-using-a-benefits-card-in-uganda-a-quasi-experimental-study
#8
Afra Nuwasiima, Elly Nuwamanya, Patricia Navvuga, Janet U Babigumira, Francis T Asiimwe, Solomon J Lubinga, Joseph B Babigumira
BACKGROUND: The use of contraception is one of the most cost-effective public health interventions and has the potential to prevent about 30% of maternal and 10% of child deaths in developing countries. Voucher-based initiatives for family planning are an effective and viable means of increasing contraceptive use. In this paper, we present a protocol for a pilot study of a novel incentive, a family planning benefits card (FPBC) program to increase uptake of family planning services among urban poor youth in Uganda while leveraging private sector funding...
October 27, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29064911/efficacy-of-antidepressants-over-placebo-is-similar-in-two-armed-versus-three-armed-or-more-armed-randomized-placebo-controlled-trials
#9
Yusuke Ogawa, Toshi A Furukawa, Nozomi Takeshima, Yu Hayasaka, Lauren Z Atkinson, Shiro Tanaka, Andrea Cipriani, Georgia Salanti
Previous studies have reported that effect sizes of antidepressants were larger in two-armed than in three-armed or more-armed (multiarmed) randomized trials, where the probability of being allocated to placebo is lower. However, these studies have not taken into account the publication bias, differences among antidepressants, or covariance in multiarmed studies, or examined sponsorship bias. We searched published and unpublished randomized-controlled trials that compared placebo with 21 antidepressants for the acute treatment of major depression in adults...
October 23, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29042406/what-data-sources-do-ophthalmologists-trust
#10
William C Stewart, Jeanette A Stewart, Lindsay A Nelson
To survey ophthalmologists regarding sources they trust when incorporating new medical knowledge into their practice. The survey was distributed primarily to US-based ophthalmologists. Questions were derived based on the lead author's research experience from congresses and discussions and from mentions in the medical literature. In total, 77 physicians completed the survey of 1886 sent (4% response rate). Regarding study design, physicians preferred a well-controlled, randomised, double-masked trial (99%) with multicentred investigational site across a wide geographical area (80%)...
October 17, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28960119/the-use-of-sports-imagery-and-terminology-on-cigarette-packs-from-fourteen-countries
#11
Cerise Kleb, Kevin Welding, Joanna E Cohen, Katherine C Smith
BACKGROUND: Tobacco companies have historically associated their products with sports through event sponsorship and sports-themed advertising campaigns. Such linkages serve to enhance brand image by connecting cigarette brands to ideals associated with sports such as strength, individual accomplishment, and a healthy body. Public health policy progress has created restrictions for tobacco sponsorship and restricted traditional advertising avenues for tobacco products. Nonetheless, the pack itself remains as a mechanism by which to link cigarettes to sports and sporting prowess...
September 29, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28953741/trends-frequency-and-nature-of-surgeon-reported-conflicts-of-interest-in-plastic-surgery
#12
REVIEW
Joseph Lopez, Leila Musavi, Amy Quan, Nicholas Calotta, Ilona Juan, Angela Park, Anthony P Tufaro, James W May, Amir H Dorafshar
BACKGROUND: The purpose of this study was to identify types and trends in industry sponsorship of plastic surgery research since the establishment of conflict-of-interest reporting policies in plastic surgery. METHODS: The authors analyzed the frequency and types of self-reported conflicts of interest in the plastic surgery literature since the adoption of reporting policies in 2007. All original articles that met the authors' inclusion criteria and were published in the following three journals from 2008 to 2013 were included: Annals of Plastic Surgery, Plastic and Reconstructive Surgery, and Journal of Plastic, Reconstructive & Aesthetic Surgery...
October 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28893095/efficacy-of-antidepressants-bias-in-randomized-clinical-trials-and-related-issues
#13
Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Tae-Youn Jun, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae
Countless antidepressant randomized trials were conducted and showed statistically significant benefits of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) over placebo. Meanwhile, critics are increasing regarding the efficacy of antidepressants in the treatment of MDD because at least a proportion of clinical trials could be hampered by various biases. In contrast, number of failed trials is increasing in the recent years which have made developing psychiatric medications progressively more time-consuming and expensive...
September 14, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28859920/sponsoring-surgeons-an-investigation-on-the-influence-of-the-da-vinci-robot
#14
Cory N Criss, Samir K Gadepalli
INTRODUCTION: The integrity of the medical literature about robotic surgery remains unclear despite wide-spread adoption. We sought to determine if payment from Intuitive Surgical Incorporated (ISI) affected quality of the research produced by surgeons. METHODS: Publicly available financial data from the CMS website regarding the top-20 earners from ISI for 2015 was gathered. Studies conducted by these surgeons were identified using PubMed. Inclusion criteria consisted of publications about the da Vinci® robot on patient outcomes...
August 26, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28827228/a-content-analysis-of-the-representation-of-statins-in-the-british-newsprint-media
#15
Julia Chisnell, Tom Marshall, Chris Hyde, Zhivko Zhelev, Lora E Fleming
OBJECTIVE: This study reviewed the news media coverage of statins, seeking to identify specific trends or differences in viewpoint between media outlets and examine common themes. DESIGN: The study is a content analysis of the frequency and content of the reporting of statins in a selection of the British newsprint media. It involved an assessment of the number, timing and thematic content of articles followed by a discourse analysis examining the underlying narratives...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28816610/tobacco-control-law-implementation-in-a-middle-income-country-transnational-tobacco-control-network-overcoming-tobacco-industry-opposition-in-colombia
#16
Randy Uang, Eric Crosbie, Stanton A Glantz
The objective of this paper is to examine the implementation of Colombia's tobacco control law. Methods involved are triangulated government legislation, news sources, and interviews with policy-makers and health advocates in Colombia. Colombia, a middle-income country, passed a tobacco control law in 2009 that included a prohibition on tobacco advertising, promotion, and sponsorship; and required pictorial health warning labels, ingredients disclosure, and a prohibition on individual cigarette sales. Tobacco companies challenged the implementation through litigation, tested government enforcement of advertising provisions and regulations on ingredients disclosure, and lobbied local governments to deprioritise policy responses to single cigarette sales...
August 17, 2017: Global Public Health
https://www.readbyqxmd.com/read/28703260/-publish-amp-perish-research-on-research-and-researchers
#17
J K Tijdink
In the last years many people have questioned the reliability of research results and the societal relevance of much of today's clinical research; they are critical too about the current publication culture in which scientists are judged according to the number of articles they have published, impact factors and citations.<br/> AIM: To make a close study of the publication culture that now prevails in the Dutch biomedical sciences. <br/> METHOD: Discussion of results described in the thesis entitled 'Publish and Perish; research on research and researchers'...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28667226/a-cross-sectional-analysis-of-pharmaceutical-industry-funded-events-for-health-professionals-in-australia
#18
Alice Fabbri, Quinn Grundy, Barbara Mintzes, Swestika Swandari, Ray Moynihan, Emily Walkom, Lisa A Bero
OBJECTIVES: To analyse patterns and characteristics of pharmaceutical industry sponsorship of events for Australian health professionals and to understand the implications of recent changes in transparency provisions that no longer require reporting of payments for food and beverages. DESIGN: Cross-sectional analysis. PARTICIPANTS AND SETTING: 301 publicly available company transparency reports downloaded from the website of Medicines Australia, the pharmaceutical industry trade association, covering the period from October 2011 to September 2015...
June 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28631099/discontinuation-of-pharmacological-treatment-of-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-meta-analysis-of-63-studies-enrolling-11-788-patients
#19
M Riera, X Castells, A Tobias, R Cunill, L Blanco, D Capellà
BACKGROUND: The risk-benefit balance of pharmacological treatment for children and adolescents with ADHD and the factors that moderate this relationship are unclear. METHODS: A systematic review and meta-analysis of randomised, placebo-controlled clinical trials (RPCCTs) investigating the efficacy of pharmacological treatment in children or adolescents with ADHD was carried out. Meta-analysis of treatment discontinuation, clinician-, parent- and teacher-rated efficacy and adverse events was performed...
September 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28595992/-food-industry-funding-and-epidemiologic-research-in-public-health-nutrition
#20
Eva María Navarrete-Muñoz, Adonina Tardón, Dora Romaguera, Miguel Ángel Martínez-González, Jesús Vioque
The interests of the food industry to fund nutrition and health research are not limited to promoting scientific advances. Recently, several systematic reviews conducted about the effect of sugar-sweetened beverages and health outcomes have shown some biased conclusions in studies that acknowledge industry sponsorship. In this context, the Nutrition Working Group of the Spanish Epidemiology Society presented a scientific session entitled Food industry and epidemiologic research at its annual meeting. In a round table, four experts in nutrition research presented their points of view about whether the food industry should fund nutrition-related research and the related potential conflicts of interest of the food industry...
June 5, 2017: Gaceta Sanitaria
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