keyword
https://read.qxmd.com/read/38476221/continuous-monitoring-of-endotracheal-tube-position-with-near-infrared-light
#1
JOURNAL ARTICLE
Tongtong Lu, Pawjai Khampang, Ahmed Beydoun, Anna Berezovsky, Rebecca Rohde, Wenzhou Hong, Bing Yu, Joseph E Kerschner
SIGNIFICANCE: Endotracheal intubation is a common approach for airway management in critically ill patients. However, the position of the endotracheal tube (ETT) may be altered during the procedure due to head movements. Accidental displacement or dislodge of the ETT may reduce the airflow, leading to moderate to severe complications, and in some cases even fatality. Therefore, timely detection of changes in ETT position in the trachea is critical to ensure immediate and intermediate interventions to maintain the ETT in the proper position...
March 2024: Journal of Biomedical Optics
https://read.qxmd.com/read/38391684/tracheal-tissue-engineering-principles-and-state-of-the-art
#2
REVIEW
Marco Mammana, Alessandro Bonis, Vincenzo Verzeletti, Andrea Dell'Amore, Federico Rea
Patients affected by long-segment tracheal defects or stenoses represent an unsolved surgical issue, since they cannot be treated with the conventional surgery of tracheal resection and consequent anastomosis. Hence, different strategies for tracheal replacement have been proposed (synthetic materials, aortic allografts, transplantation, autologous tissue composites, and tissue engineering), each with advantages and drawbacks. Tracheal tissue engineering, on the other hand, aims at recreating a fully functional tracheal substitute, without the need for the patient to receive lifelong immunosuppression or endotracheal stents...
February 19, 2024: Bioengineering
https://read.qxmd.com/read/38366558/embryonic-spatio-temporal-expression-pattern-of-folded-gastrulation-fog-suggests-roles-in-multiple-morphogenetic-events-and-regulation-by-abda
#3
JOURNAL ARTICLE
Vrushali Katagade, Manisha Kandroo, Anuradha Ratnaparkhi
In Drosophila, the signaling pathway activated by the ligand Folded gastrulation (Fog) is amongst the few known G-protein coupled receptor (GPCR) pathways to regulate cell shape change with a well characterized role in gastrulation. However, an understanding of the spectrum of morphogenetic events regulated by Fog signaling is still lacking. Here, we present an analysis of the expression pattern and regulation of fog using a genome engineered Fog::sfGFP line. We show that Fog expression is widespread and in tissues previously not associated with the signaling pathway including germ cells, trachea and amnioserosa...
February 15, 2024: G3: Genes—Genomes—Genetics
https://read.qxmd.com/read/38353908/preparation-of-decellularized-tissue-as-dual-cell-carrier-systems-a-step-towards-facilitating-re-epithelization-and-cell-encapsulation-for-tracheal-reconstruction
#4
JOURNAL ARTICLE
Pensuda Sompunga, Watchareewan Rodprasert, Sayamon Srisuwatanasagul, Somporn Techangamsuwan, Sirinee Jirajessada, Rattanavinan Hanchaina, Thaned Kangsamaksin, Supansa Yodmuang, Chenphop Sawangmake
Surgical treatment of tracheal diseases, trauma, and congenital stenosis has shown success through tracheal reconstruction coupled with palliative care. However, challenges in surgical-based tracheal repairs have prompted the exploration of alternative approaches for tracheal replacement. Tissue-based treatments, involving the cultivation of patient cells on a network of extracellular matrix (ECM) from donor tissue, hold promise for restoring tracheal structure and function without eliciting an immune reaction...
February 14, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38265006/artificial-trachea-from-microtissue-engineering-and-3d-printing-for-tracheal-personalized-repair
#5
JOURNAL ARTICLE
Chao Qi, Lu Cheng, Chuanqi Huang
Millions of people suffer from tracheal defect worldwide each year, while autograft and allograft cannot meet existing treatment needs. Tissue-engineered trachea substitutes represent a promising treatment for tracheal defect, while lack of precisely personalize treatment abilities. Therefore, development of an artificial trachea that can be used for personalized transplantation is highly desired. Here, we reported the design and fabrication of an artificial trachea based on sericin microsphere by microtissue engineering technology and 3D printing for personalized repair of tracheal defect...
January 24, 2024: Tissue Engineering. Part A
https://read.qxmd.com/read/38256300/surgical-innovations-in-tracheal-reconstruction-a-review-on-synthetic-material-fabrication
#6
REVIEW
Usman Khalid, Petar Uchikov, Bozhidar Hristov, Krasimir Kraev, Maria Koleva-Ivanova, Maria Kraeva, Atanas Batashki, Daniela Taneva, Mladen Doykov, Angel Uchikov
Background and Objectives : The aim of this review is to explore the recent surgical innovations in tracheal reconstruction by evaluating the uses of synthetic material fabrication when dealing with tracheomalacia or stenotic pathologies, then discussing the challenges holding back these innovations. Materials and Methods : A targeted non-systematic review of published literature relating to tracheal reconstruction was performed within the PubMed database to help identify how synthetic materials are utilised to innovate tracheal reconstruction...
December 25, 2023: Medicina
https://read.qxmd.com/read/38205070/synergistic-effects-of-sds-and-h-2-o-2-combinations-on-tracheal-scaffold-development-an-in-vitro-study-using-goat-trachea
#7
JOURNAL ARTICLE
Dhihintia Jiwangga, Ferdiansyah Mahyudin, Gondo Mastutik, Estya Nadya Meitavany, Juliana, Priangga Adi Wiratama
Currently, a tissue-engineered trachea has been popularly used as a biological graft for tracheal replacement in severe respiratory diseases. In the development of tissue-engineered tracheal scaffolds, in vitro studies play a crucial role in allowing researchers to evaluate the efficacy and safety of scaffold designs and fabrication techniques before progressing to in vivo or clinical trials. This research involved the decellularization of goat trachea using SDS, H2 O2 , and their combinations. Various quantitative and qualitative assessments were performed, including histological analysis, immunohistochemistry, and biomechanical testing...
2024: International Journal of Biomaterials
https://read.qxmd.com/read/38198708/cation-crosslinked-%C3%AE%C2%BA-carrageenan-sub-microgel-medium-for-high-quality-embedded-bioprinting
#8
JOURNAL ARTICLE
Hua Zhang, Yang Luo, Zeming Hu, Mengxi Chen, Shang Chen, Yudong Yao, Jie Yao, Xiaoqi Shao, Kerong Wu, Yabin Zhu, Jun Fu
Three-dimensional (3D) bioprinting embedded within a microgel bath has emerged as a promising strategy for creating intricate biomimetic scaffolds. However, it remains a great challenge to construct tissue-scale structures with high resolution by using embedded 3D bioprinting due to the large particle size and polydispersity of the microgel medium, as well as its limited cytocompatibility. To address these issues, novel uniform sub-microgels of cell-friendly cationic-crosslinked kappa-carrageenan (κ-Car) are developed through an easy-to-operate mechanical grinding strategy...
January 10, 2024: Biofabrication
https://read.qxmd.com/read/38105967/4d-bioprinted-self-folding-scaffolds-enhance-cartilage-formation-in-the-engineering-of-trachea
#9
Irene Chiesa, Alessio Esposito, Giovanni Vozzi, Riccardo Gottardi, Carmelo De Maria
Trachea defects that required surgical interventions are increasing in number in the recent years, especially for pediatric patients. However, current gold standards, such as biological grafts and synthetic prothesis, do not represent an effective solution, due to the lack of mimicry and regeneration capability. Bioprinting is a cutting-edge approach for the fabrication of biomimetic scaffold to empower tissue engineering toward trachea replacement. In this study, we developed a self-folding gelatin-based bilayer scaffold for trachea engineering, exploiting the 4D bioprinting approach, namely the fabrication of dynamic scaffolds, able to shape morph in a predefined way after the application of an environmental stimulus...
December 8, 2023: bioRxiv
https://read.qxmd.com/read/38069106/post-implantation-inflammatory-responses-to-xenogeneic-tissue-engineered-cartilage-implanted-in-rabbit-trachea-the-role-of-cultured-chondrocytes-in-the-modification-of-inflammation
#10
JOURNAL ARTICLE
Ilya Klabukov, Dmitri Atiakshin, Evgenia Kogan, Michael Ignatyuk, Mikhail Krasheninnikov, Nickolay Zharkov, Anna Yakimova, Vyacheslav Grinevich, Pavel Pryanikov, Vladimir Parshin, Dmitry Sosin, Andrey A Kostin, Peter Shegay, Andrey D Kaprin, Denis Baranovskii
Immune responses to tissue-engineered grafts made of xenogeneic materials remain poorly studied. The scope of current investigations is limited by the lack of information on orthotopically implanted grafts. A deeper understanding of these processes is of great importance since innovative surgical approaches include the implantation of xenogeneic decellularized scaffolds seeded by cells. The purpose of our work is to study the immunological features of tracheal repair during the implantation of tissue-engineered constructs based on human xenogeneic scaffolds modified via laser radiation in rabbits...
November 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37950719/comparative-study-of-immunodeficient-rat-strains-in-engraftment-of-hipsc-derived-airway-epithelia
#11
JOURNAL ARTICLE
Yasuyuki Hayashi, Hiroe Ohnishi, Masayuki Kitano, Yo Kishimoto, Toshiaki Takezawa, Hideaki Okuyama, Masayoshi Yoshimatsu, Fumihiko Kuwata, Takeshi Tada, Keisuke Mizuno, Koichi Omori
The airway epithelia (AE) play a role in the clearance of foreign substances through ciliary motility and mucus secreted. We developed an artificial trachea that is made of collagen sponges and polypropylene mesh for the regeneration of the tracheal defect, and it was used for a clinical study. Then, a model in which the luminal surface of an artificial trachea covered with a human-induced pluripotent stem cell-derived AE (hiPSC-AE) was transplanted into the tracheal defect of nude rats to promote epithelialization...
November 11, 2023: Tissue Engineering. Part A
https://read.qxmd.com/read/37927226/application-of-tissue-engineering-techniques-in-tracheal-repair-a-bibliometric-study
#12
JOURNAL ARTICLE
Xiangyu Xu, Zhiming Shen, Yibo Shan, Fei Sun, Yi Lu, Jianwei Zhu, Yiqi Sun, Hongcan Shi
Transplantation of tissue-engineered trachea is an effective treatment for long-segment tracheal injury. This technology avoids problems associated with a lack of donor resources and immune rejection, generating an artificial trachea with good biocompatibility. To our knowledge, a systematic summary of basic and clinical research on tissue-engineered trachea in the last 20 years has not been conducted. Here, we analyzed the development trends of tissue-engineered trachea research by bibliometric means and outlined the future perspectives in this field...
December 2023: Bioengineered
https://read.qxmd.com/read/37920292/construction-of-a-novel-cell-free-tracheal-scaffold-promoting-vascularization-for-repairing-tracheal-defects
#13
JOURNAL ARTICLE
Zhiming Shen, Fei Sun, Yibo Shan, Yi Lu, Cong Wu, Boyou Zhang, Qiang Wu, Lei Yuan, Jianwei Zhu, Qi Wang, Yilun Wang, Wenxuan Chen, Yaojing Zhang, Wenlong Yang, Yiwei Fan, Hongcan Shi
Functional vascularization is crucial for maintaining the long-term patency of tissue-engineered trachea and repairing defective trachea. Herein, we report the construction and evaluation of a novel cell-free tissue-engineered tracheal scaffold that effectively promotes vascularization of the graft. Our findings demonstrated that exosomes derived from endothelial progenitor cells (EPC-Exos) enhance the proliferation, migration, and tube formation of endothelial cells. Taking advantage of the angiogenic properties of EPC-Exos, we utilized methacrylate gelatin (GelMA) as a carrier for endothelial progenitor cell exosomes and encapsulated them within a 3D-printed polycaprolactone (PCL) scaffold to fabricate a composite tracheal scaffold...
December 2023: Materials today. Bio
https://read.qxmd.com/read/37918216/decellularized-tracheal-scaffold-as-a-promising-3d-scaffold-for-tissue-engineering-applications
#14
JOURNAL ARTICLE
Aida Nahumi, Maryam Peymani, Asadollah Asadi, Arash Abdolmaleki, Yassin Panahi
Tissue engineering is a science that uses the combination of scaffolds, cells, and active biomolecules to make tissue in order to restore or maintain its function and improve the damaged tissue or even an organ in the laboratory. The purpose of this research was to study the characteristics and biocompatibility of decellularized sheep tracheal scaffolds and also to investigate the differentiation of Adipose-derived stem cells (AD-MSCs) into tracheal cells. After the decellularization of sheep tracheas through the detergent-enzyme method, histological evaluations, measurement of biochemical factors, measurement of DNA amount, and photographing the ultrastructure of the samples by scanning electron microscopy (SEM), they were also evaluated mechanically...
October 25, 2023: Tissue & Cell
https://read.qxmd.com/read/37916766/tracheal-replacement-techniques-and-associated-mortality-a-systematic-review
#15
REVIEW
Wen-Hui Tseng, En-Wei Liu, Kai-Yuan Cheng, Shyun-Jing Wee, Jian-Jr Lee, Hung-Chi Chen
OBJECTIVE: Tracheal replacement is a crucial operation to enhance the quality of life for patients with extensive tracheal lesions. The most suitable surgical techniques for different clinical conditions remain a topic of debate. Through a reviewing of the relevant literature, this study investigated the association between surgical techniques and mortality rate. DATA SOURCES: Studies were collected from PubMed, Embase, the Web of Science, the Cochrane Center Register of Controlled Trials, and ClinicalTrials...
November 2, 2023: Laryngoscope
https://read.qxmd.com/read/37903510/macchiarini-lancet-retracts-two-papers-on-first-tissue-engineered-trachea-transplant
#16
JOURNAL ARTICLE
Elisabeth Mahase
No abstract text is available yet for this article.
October 30, 2023: BMJ: British Medical Journal
https://read.qxmd.com/read/37844823/decellularized-extracellular-matrix-and-silk-fibroin-based-hybrid-biomaterials-a-comprehensive-review-on-fabrication-techniques-and-tissue-specific-applications
#17
REVIEW
Soham Ghosh, Falguni Pati
Biomaterials play a fundamental role in tissue engineering by providing biochemical and physical cues that influence cellular fate and matrix development. Decellularized extracellular matrix (dECM) as a biomaterial is distinguished by its abundant composition of matrix proteins, such as collagen, elastin, fibronectin, and laminin, as well as glycosaminoglycans and proteoglycans. However, the mechanical properties of only dECM-based constructs may not always meet tissue-specific requirements. Recent advancements address this challenge by utilizing hybrid biomaterials that harness the strengths of silk fibroin (SF), which contributes the necessary mechanical properties, while dECM provides essential cellular cues for in vitro studies and tissue regeneration...
October 14, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37808012/anastomotic-stenosis-of-bioengineered-trachea-grafts-is-driven-by-transforming-growth-factor-%C3%AE-1-induced-signaling-proinflammatory-macrophages-and-delayed-epithelialization
#18
JOURNAL ARTICLE
Joanna Weber, Russell Seth Martins, Zaid Muslim, Mirza Zain Baig, Kostantinos Poulikidis, Al Haitham Al Shetawi, Faiz Y Bhora
OBJECTIVE: Anastomotic stenosis caused by hypertrophic granulation tissue often develops in response to orthotopically implanted bioengineered tracheal grafts. To determine mechanisms responsible for the development and persistence of this granulation tissue, we looked for changes in gene expression from tissue specimens from the graft-native interface. METHODS: RNA was isolated from paraffin-embedded tissue samples of the anastomotic sites of orthotopically implanted bioengineered tracheal grafts of 9 animals...
September 2023: JTCVS open
https://read.qxmd.com/read/37693070/partial-decellularization-eliminates-immunogenicity-in-tracheal-allografts
#19
JOURNAL ARTICLE
Zheng Hong Tan, Lumei Liu, Sayali Dharmadhikari, Kimberly M Shontz, Lily Kreber, Sarah Sperber, Jane Yu, Woo Yul Byun, Sarah C Nyirjesy, Amy Manning, Susan D Reynolds, Tendy Chiang
There is currently no suitable autologous tissue to bridge large tracheal defects. As a result, no standard of care exists for long-segment tracheal reconstruction. Tissue engineering has the potential to create a scaffold from allografts or xenografts that can support neotissue regeneration identical to the native trachea. Recent advances in tissue engineering have led to the idea of partial decellularization that allows for the creation of tracheal scaffolds that supports tracheal epithelial formation while preserving mechanical properties...
September 2023: Bioengineering & Translational Medicine
https://read.qxmd.com/read/37658839/global-bibliometric-and-visualized-analysis-of-tracheal-tissue-engineering-research
#20
JOURNAL ARTICLE
Jianwei Zhu, Yi Lu, Yibo Shan, Lei Yuan, Qiang Wu, Zhiming Shen, Fei Sun, Hongcan Shi
The development of tracheal tissue engineering has seen a rapid growth in recent years. The purpose of this study was to investigate the global status, trends, and hotspots of tracheal tissue engineering research based on bibliometrics and visualization analysis. Publications related to tracheal tissue engineering were retrieved and included in the Web of Science Core Collection. VOSviewer and CiteSpace were used to generate knowledge maps. 655 publications were identified, and the quantity of the annual publications worldwide was on the increase...
September 2, 2023: Tissue Engineering. Part B, Reviews
keyword
keyword
30454
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.