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walter klepetko

Konrad Hoetzenecker, Thomas Schweiger, Imme Roesner, Matthias Leonhard, Gabriel Marta, Doris M Denk-Linnert, Berit Schneider-Stickler, Wolfgang Bigenzahn, Walter Klepetko
OBJECTIVES: Repair of laryngotracheal stenosis with pronounced side-to-side narrowing and involvement of the glottis is challenging and usually requires laryngotracheal reconstruction with rib cartilage interpositions. This technique, as first described by Couraud, needs prolonged postoperative stabilization with Montgomery T-tubes, imposing significant morbidity and discomfort on patients. We describe our initial experience with a modified laryngotracheal reconstruction technique that avoids the need for prolonged postoperative stenting...
October 2016: Journal of Thoracic and Cardiovascular Surgery
Christian Geltner, Peter Errhalt, Bernhard Baumgartner, Gerhard Ambrosch, Barbara Machan, Josef Eckmayr, Thomas Klikovits, Mir Alireza Hoda, Helmut Popper, Walter Klepetko
Malignant pleural mesothelioma is a rare malignant disease that in the majority of cases is associated with asbestos exposure. The incidence in Europe is about 20 per million inhabitants and it is increasing worldwide. Initial symptoms are shortness of breath, pleural effusion, cough, and chest pain. The typical growth pattern is along the pleural surface; however, infiltration of the lung and/or mediastinal and chest wall structures can occur in a more advanced stage. Ultimately, distant metastases outside the chest can result...
September 2016: Wiener Klinische Wochenschrift
Chandran Nagaraj, Bi Tang, Bence M Nagy, Rita Papp, Pritesh P Jain, Leigh M Marsh, Andrea L Meredith, Bahil Ghanim, Walter Klepetko, Grazyna Kwapiszewska, E Kenneth Weir, Horst Olschewski, Andrea Olschewski
Cardioprotective benefits of ω-3 fatty acids such as docosahexaenoic acid (DHA) are well established, but the regulatory effect of DHA on vascular tone and pressure in pulmonary hypertension is largely unknown.As DHA is a potent regulator of K(+) channels, we hypothesised that DHA modulates the membrane potential of pulmonary artery smooth muscle cells (PASMCs) through K(+) channels and thus exerts its effects on pulmonary vascular tone and pressure.We show that DHA caused dose-dependent activation of the calcium-activated K(+) (KCa) current in primary human PASMCs and endothelium-dependent relaxation of pulmonary arteries...
October 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Mir A Hoda, Christine Pirker, Yawen Dong, Karin Schelch, Petra Heffeter, Kushtrim Kryeziu, Sushilla van Schoonhoven, Thomas Klikovits, Viktoria Laszlo, Anita Rozsas, Judit Ozsvar, Walter Klepetko, Balazs Döme, Michael Grusch, Balazs Hegedüs, Walter Berger
Malignant pleural mesothelioma (MPM) is characterized by widespread resistance to systemic therapy. Trabectedin is an antineoplastic agent targeting both the malignant cells and the tumor microenvironment that has been approved for the treatment of advanced soft tissue sarcoma and ovarian cancer. In this preclinical study, we evaluated the antineoplastic potential of trabectedin as a single agent and in drug combination approaches in human MPM. Therefore, we utilized an extended panel of MPM cell lines (n = 6) and primary cell cultures from surgical MPM specimens (n = 13), as well as nonmalignant pleural tissue samples (n = 2)...
October 2016: Molecular Cancer Therapeutics
Thomas Klikovits, Mir Alireza Hoda, Yawen Dong, Madeleine Arns, Bernhard Baumgartner, Peter Errhalt, Christian Geltner, Barbara Machan, Wolfgang Pohl, Jörg Hutter, Josef Eckmayr, Michael Studnicka, Martin Flicker, Peter Cerkl, Klaus Kirchbacher, Walter Klepetko
BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor originating from the pleural cavity with a strong link to previous asbestos exposure. In order to determine the demographics, diagnostics, therapeutic strategies, and prognosis of MPM patients in Austria, the Austrian Mesothelioma Interest Group (AMIG) was founded in 2011. In this report the data from the AMIG MPM database collected to date are reported. METHODS: A prospective observational registry was initiated, including patients with histologically verified MPM diagnosed and treated at specialized centers in Austria...
September 2016: Wiener Klinische Wochenschrift
Mir Alireza Hoda, Thomas Klikovits, Madeleine Arns, Karin Dieckmann, Sabine Zöchbauer-Müller, Christian Geltner, Bernhard Baumgartner, Peter Errhalt, Barbara Machan, Wolfgang Pohl, Jörg Hutter, Josef Eckmayr, Michael Studnicka, Martin Flicker, Peter Cerkl, Walter Klepetko
Treatment of malignant pleural mesothelioma (MPM) depends on performance status of the patient, tumor stage, and histological differentiation. Chemotherapy (CHT) can be administered as first- and second-line treatment in unresectable MPM or as neoadjuvant or adjuvant treatment before or after surgery. A combination of an antifolate and platinum-based CHT is the only approved standard of care. Several targeted and immunotherapies are in evaluation and further studies are warranted to determine the therapeutic value of these new treatment options...
September 2016: Wiener Klinische Wochenschrift
Walter Klepetko
No abstract text is available yet for this article.
September 2016: Wiener Klinische Wochenschrift
Thomas Schweiger, Anna Sophie Berghoff, Christoph Glogner, Olaf Glueck, Orsolya Rajky, Denise Traxler, Peter Birner, Matthias Preusser, Walter Klepetko, Konrad Hoetzenecker
The presence of tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) reflects an active inflammatory tumor microenvironment. High density of TILs as well as presence of TLS is associated with improved survival in various solid cancer types. We aimed to describe the density and distribution of TILs and TLS in pulmonary metastases (PMs) from primary colorectal cancer (CRC) and its correlation with clinicopathological variables. Fifty-seven CRC pulmonary metastasectomy specimen (PM) and 31 matched primary CRC specimen were included...
October 2016: Clinical & Experimental Metastasis
Thomas Klikovits, Christopher Lambers, Bahil Ghanim, Balazs Dome, Gabriella Murakoezy, Sabine Zöchbauer-Müller, Ryuichi Waseda, Clemens Aigner, Gyoergy Lang, Shahrokh Taghavi, Walter Klepetko, Peter Jaksch, Mir Alireza Hoda
BACKGROUND: Incidentally discovered lung cancers in lung transplant (LuTX) recipients are rare but may affect outcome. We aim to report our single center experience with incidence, management, and survival of patients with previously unverified primary lung cancer discovered at the time of LuTX. METHODS: A total of 1262 patients undergoing LuTX between 1989 and 2012 were retrospectively analyzed in our prospective database. RESULTS: Patients identified were six men and five women with a mean age of 54...
August 2016: Clinical Transplantation
Denise Traxler, Thomas Schweiger, Stefan Schwarz, Magdalena Maria Schuster, Peter Jaksch, Gyoergy Lang, Peter Birner, Walter Klepetko, Hendrik Jan Ankersmit, Konrad Hoetzenecker
BACKGROUND: Chronic lung allograft dysfunction (CLAD), presenting as bronchiolitis obliterans syndrome (BOS) or restrictive allograft syndrome (RAS) is the major limiting factor of long-term survival in lung transplantation. Its pathogenesis is still obscure. In BOS, persistent alloimmune injury and chronic airway inflammation are suggested. One of the main tasks of the lymphatic vessel (LV) system is the promotion of immune cell trafficking. The formation of new LVs has been shown to trigger chronic allograft rejection in kidney transplants...
May 10, 2016: Transplantation
Slaven Crnkovic, Albrecht Schmidt, Bakytbek Egemnazarov, Jochen Wilhelm, Leigh M Marsh, Bahil Ghanim, Walter Klepetko, Andrea Olschewski, Horst Olschewski, Grazyna Kwapiszewska
Adaptation of the right ventricle (RV) to increased afterload is crucial for survival in pulmonary hypertension (PH), but it is challenging to assess RV function and identify associated molecular mechanisms. The aim of the current study was to analyze the relationship between invasive and noninvasive parameters of RV morphology and function and associated molecular changes. The response of mice to normobaric hypoxia was assessed by hechocardiography, invasive hemodynamics, and histological and molecular analyses...
July 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
Vasile Foris, Gabor Kovacs, Leigh M Marsh, Zoltán Bálint, Martin Tötsch, Alexander Avian, Philipp Douschan, Bahil Ghanim, Walter Klepetko, Andrea Olschewski, Horst Olschewski
Circulating mononuclear cells may play an important role for the vascular remodelling in pulmonary arterial hypertension (PAH), but studies addressing multiple progenitor populations are rare and inconsistent.We used a comprehensive fluorescence-activated cell sorting analysis of circulating mononuclear cells in 20 PAH patients and 20 age- and sex-matched controls, and additionally analysed CD133(+) cells in the lung tissue of five PAH transplant recipients and five healthy controls (donor lungs).PAH patients were characterised by increased numbers of circulating CD133(+) cells and lymphopenia as compared with control...
August 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
David P Jenkins, Andrzej Biederman, Andrea M D'Armini, Philippe G Dartevelle, Hui-Li Gan, Walter Klepetko, Jaroslav Lindner, Eckhard Mayer, Michael M Madani
Pulmonary endarterectomy is the gold standard treatment for chronic thromboembolic pulmonary hypertension and is potentially curative, although some patients are unsuitable for pulmonary endarterectomy and require alternative management. Lack of standardized assessment of pulmonary endarterectomy eligibility risks suboptimal treatment in some patients. We discuss the implications for future clinical trials and practice of a unique operability assessment in patients who have chronic thromboembolic pulmonary hypertension and were initially screened for inclusion in the CHEST-1 (Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase Stimulator Trial-1) study...
September 2016: Journal of Thoracic and Cardiovascular Surgery
Mir Alireza Hoda, Anita Rozsas, Elisabeth Lang, Thomas Klikovits, Zoltan Lohinai, Szilvia Torok, Judit Berta, Matyas Bendek, Walter Berger, Balazs Hegedus, Walter Klepetko, Ferenc Renyi-Vamos, Michael Grusch, Balazs Dome, Viktoria Laszlo
Activin A (ActA)/follistatin (FST) signaling has been shown to be deregulated in different tumor types including lung adenocarcinoma (LADC). Here, we report that serum ActA protein levels are significantly elevated in LADC patients (n=64) as compared to controls (n=46, p=0.015). ActA levels also correlated with more advanced disease stage (p<0.0001) and T (p=0.0035) and N (p=0.0002) factors. M1 patients had significantly higher ActA levels than M0 patients (p<0.001). High serum ActA level was associated with poor overall survival (p<0...
March 22, 2016: Oncotarget
Andris Skride, Kristaps Sablinskis, Walter Klepetko, Irene Lang
No abstract text is available yet for this article.
May 7, 2016: European Heart Journal
Thomas Schweiger, Stefan Schwarz, Denise Traxler, Philippe Dodier, Clemens Aigner, György Lang, Walter Klepetko, Konrad Hoetzenecker
BACKGROUND: Anastomotic failure is a rare but severe complication after airway surgery. A sufficient blood supply is crucial for the healing of the anastomosis. Currently, judging the appearance of the mucosa by conventional bronchoscopy is the only available technique to monitor the anastomosis. Near-infrared imaging using indocyanine green (ICG) as an intravasal fluorescent can be used to directly assess tissue perfusion. For technical reasons, bronchoscopic ICG angiography to evaluate blood supply of airway anastomosis was unavailable in the past...
May 2016: Annals of Thoracic Surgery
Lukas Weseslindtner, Irene Görzer, Kevin Roedl, Erik Küng, Peter Jaksch, Walter Klepetko, Elisabeth Puchhammer-Stöckl
BACKGROUND: In lung transplant recipients (LTRs), human cytomegalovirus (HCMV) DNA detection in the bronchoalveolar lavage fluid (BALF) indicates HCMV replication in the pulmonary compartment. Such local HCMV replication episodes may remain asymptomatic or may lead to symptomatic HCMV disease. Here, we investigated LTRs with intrapulmonary HCMV replication for the chemokines CCL-18 and CCL-20. In particular, we analyzed whether these chemokines rise in the allograft and/or the blood and are associated with HCMV disease...
January 20, 2016: Transplantation
Thomas Klikovits, Alexis Slama, Konrad Hoetzenecker, Ryuichi Waseda, Christopher Lambers, Gabriella Murakoezy, Peter Jaksch, Clemens Aigner, Shahrokh Taghavi, Walter Klepetko, Gyoergy Lang, Mir Alireza Hoda
BACKGROUND: Pulmonary alveolar microlithiasis (PAM) is a rare lung disease caused by calcifications within the alveolar space. The only known effective treatment for an end-stage PAM is lung transplantation (LuTX). METHODS: We performed a retrospective chart review of all individuals that underwent lung transplantation at our center between 1989 and 2013. Five consecutive patients with PAM were identified. RESULTS: Four females and one male with a mean age of 46...
April 2016: Clinical Transplantation
Nazzareno Galiè, Marc Humbert, Jean-Luc Vachiery, Simon Gibbs, Irene Lang, Adam Torbicki, Gérald Simonneau, Andrew Peacock, Anton Vonk Noordegraaf, Maurice Beghetti, Ardeschir Ghofrani, Miguel Angel Gomez Sanchez, Georg Hansmann, Walter Klepetko, Patrizio Lancellotti, Marco Matucci, Theresa McDonagh, Luc A Pierard, Pedro T Trindade, Maurizio Zompatori, Marius Hoeper
No abstract text is available yet for this article.
February 2016: Revista Española de Cardiología
Benedikt Simon, Lukas Weseslindtner, Irene Görzer, Karin Pollak, Peter Jaksch, Walter Klepetko, Elisabeth Puchhammer-Stöckl
BACKGROUND: Human cytomegalovirus (HCMV) causes severe infections in transplant recipients. The significance of the HCMV-specific antibody (Ab) response in limiting HCMV replication is not clear. Therefore, we analyzed the HCMV-specific subclass Ab profile in lung transplant recipients (LTRs) and its association with the genomic immunoglobulin G (IgG) heavy-chain variants GM3/17 and HCMV DNAemia. METHODS: We determined HCMV-specific total IgG, IgG1 and IgG3 Ab levels by enzyme-linked immunoassay and HCMV-DNAemia by quantitative polymerase chain reaction during post-transplant follow-up in 57 LTRs and, in 44 of these recipients, the genetic allotype marker 359a/g variants (reflecting GM3/17 allotypes) by genotyping...
March 2016: Journal of Heart and Lung Transplantation
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