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walter klepetko

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https://www.readbyqxmd.com/read/29233352/progressive-stenosis-of-both-main-bronchi-associated-with%C3%A2-recurrent-infections-of-a%C3%A2-carinal-pouch
#1
Thomas Schweiger, Konrad Hoetzenecker, Helmut Prosch, Martin Hackl, Berta Oszvath, György Lang, Walter Klepetko
A 55-year-old woman was referred to our department with a bilateral stenosis of both main bronchi starting at the level of the carina and a blind-ended pouch originating from the carina. Differential diagnosis of diffuse narrowing of the intrathoracic central airways was excluded during the diagnostic workup. Recurrent infection of the blind-ended pouch remained a possible explanation of this unusual type of stenosis. Carinal resection and reconstruction by end-to-end anastomosis of the trachea to the right main bronchus and reimplantation of the left main bronchus to the intermediate bronchus with intraoperative extracorporeal membrane oxygen support resulted in an excellent long-term outcome...
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29184132/circulating-complement-component-4d-c4d-correlates-with-tumor-volume-chemotherapeutic-response-and-survival-in-patients-with-malignant-pleural-mesothelioma
#2
Thomas Klikovits, Paul Stockhammer, Viktoria Laszlo, Yawen Dong, Mir Alireza Hoda, Bahil Ghanim, Isabelle Opitz, Thomas Frauenfelder, Thi Dan Linh Nguyen-Kim, Walter Weder, Walter Berger, Michael Grusch, Clemens Aigner, Walter Klepetko, Balazs Dome, Ferenc Renyi-Vamos, Rudolf Oehler, Balazs Hegedus
Only limited information is available on the role of complement activation in malignant pleural mesothelioma (MPM). Thus, we investigated the circulating and tissue levels of the complement component 4d (C4d) in MPM. Plasma samples from 55 MPM patients, 21 healthy volunteers (HV) and 14 patients with non-malignant pleural diseases (NMPD) were measured by ELISA for C4d levels. Tissue specimens from 32 patients were analyzed by C4d immunohistochemistry. Tumor volumetry was measured in 20 patients. We found no C4d labeling on tumor cells, but on ectopic lymphoid structures within the tumor stroma...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095649/loss-of-smad3-promotes-vascular-remodeling-in-pulmonary-arterial-hypertension-via-mrtf-disinhibition
#3
Diana Zabini, Elise Granton, Yijie Hu, Maria Zena Miranda, Ulrike Weichelt, Sandra Breuils Bonnet, Sébastien Bonnet, Nicholas W Morrell, Kim A Connelly, Steeve Provencher, Bahil Ghanim, Walter Klepetko, Andrea Olschewski, Andras Kapus, Wolfgang M Kuebler
INTRODUCTION: Vascular remodeling in pulmonary arterial hypertension (PAH) results from smooth muscle cell hypertrophy and proliferation of vascular cells. Loss of bone morphogenetic protein receptor 2 (BMPR-II) signaling and increased signaling via transforming growth factor β (TGF-β) and its downstream mediators SMAD2/3 has been proposed to drive lung vascular remodeling; yet, proteomic analyses indicate a loss of SMAD3 in PAH. OBJECTIVE: We proposed that SMAD3 may be dysregulated in PAH, and that loss of SMAD3 may present a master switch in the disease process by disinhibiting its interaction partner myocardin-related transcription factor (MRTF) which drives muscle protein expression...
November 2, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29078633/thymic-minimally-invasive-surgery-state-of-the-art-across-the-world-europe
#4
REVIEW
José Ramon Matilla, Walter Klepetko, Bernhard Moser
In this brief review of selected peer-reviewed literature on thymic minimally-invasive surgery (MIS) we sought to identify if there is a unique approach to thymic MIS on the European continent.
2017: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29055604/treatment-of-primary-graft-dysfunction-after-lung-transplantation-with-orally-inhaled-ap301-a-prospective-randomized-pilot-study
#5
Clemens Aigner, Alexis Slama, Maximilian Barta, Andreas Mitterbauer, Gyoergy Lang, Shahrokh Taghavi, Jose Matilla, Roman Ullrich, Katharina Krenn, Peter Jaksch, Klaus Markstaller, Walter Klepetko
BACKGROUND: Primary graft dysfunction (PGD) after lung transplantation (LTx) carries significant morbidity and mortality in the early post-operative period and is associated with the development of chronic lung allograft dysfunction. AP301, an activator of epithelial sodium channel-mediated Na(+) uptake represents a new concept for prevention and treatment of pulmonary edema and has shown promising results in the pre-clinical setting. This pilot study investigated the clinical effect of inhaled AP301 on patients with development of PGD > 1 according to International Society of Heart and Lung Transplantation criteria after primary LTx in a high-volume center and was conducted as a randomized, placebo-controlled, single-center pilot-study including 20 patients...
September 30, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29016397/feasibility-and-reliability-of-functional-muscle-tests-in-lung-transplant-recipients
#6
Thomas Kienbacher, Grace Achim-Gunacker, Melanie Pachner, Katharina Kerschan-Schindl, Patrik Gunacker, Richard Habenicht, Walter Klepetko, Peter Jaksch, Stephan Doblhammer, Gerold Ebenbichler
OBJECTIVE: This study investigates the feasibility, reliability, and correlations of recommended functional tests in lung transplant recipients shortly after surgery. DESIGN: Observational study METHODS: 50 patients (28 females) performed well standardized maximum isometric back extension in a sitting position, hand grip strength, and Biering-Sørensen endurance tests shortly before discharge from the acute hospital, shortly thereafter, and two months later following subacute rehabilitation...
October 10, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28970578/intrathoracic-solitary-fibrous-tumor-an-international-multicenter-study-on-clinical-outcome-and-novel-circulating-biomarkers
#7
Bahil Ghanim, Sebastian Hess, Pietro Bertoglio, Ali Celik, Aynur Bas, Felicitas Oberndorfer, Franca Melfi, Alfredo Mussi, Walter Klepetko, Christine Pirker, Walter Berger, Imrich Harmati, Attila Farkas, Hendrik Jan Ankersmit, Balazs Dome, Janos Fillinger, Clemens Aigner, Balazs Hegedus, Ferenc Renyi-Vamos, György Lang
Intrathoracic solitary fibrous tumor (SFT) is a rare disease. Radical resection is the standard of care. However, estimating prognosis and planning follow-up and treatment strategies remains challenging. Data were retrospectively collected by five international centers to explore outcome and biomarkers for predicting event-free-survival (EFS). 125 histological proven SFT patients (74 female; 59.2%; 104 benign; 83.2%) were analyzed. The one-, three-, five- and ten-year EFS after curative-intent surgery was 98%, 90%, 77% and 67%, respectively...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28950326/lung-transplantation-for-idiopathic-pulmonary-arterial-hypertension-on-intraoperative-and-postoperatively-prolonged-extracorporeal-membrane-oxygenation-provides-optimally-controlled-reperfusion-and-excellent-outcome
#8
Bernhard Moser, Peter Jaksch, Shahrokh Taghavi, Gabriella Muraközy, Georg Lang, Helmut Hager, Claus Krenn, Georg Roth, Peter Faybik, Andreas Bacher, Clemens Aigner, José R Matilla, Konrad Hoetzenecker, Philipp Hacker, Irene Lang, Walter Klepetko
OBJECTIVES: Lung transplantation for idiopathic pulmonary arterial hypertension has the highest reported postoperative mortality of all indications. Reasons lie in the complexity of treatment of these patients and the frequent occurrence of postoperative left ventricular failure. Transplantation on intraoperative extracorporeal membrane oxygenation support instead of cardiopulmonary bypass and even more the prolongation of extracorporeal membrane oxygenation into the postoperative period helps to overcome these problems...
July 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28932634/pd1-positive-tumor-infiltrating-lymphocytes-are-associated-with-poor-clinical-outcome-after-pulmonary-metastasectomy-for-colorectal-cancer
#9
Dagmar Kollmann, Thomas Schweiger, Stefan Schwarz, Desislava Ignatova, Yun-Tsan Chang, Gerrit Lewik, Sebastian F Schoppmann, Wolfram Hoetzenecker, Walter Klepetko, Emmanuella Guenova, Konrad Hoetzenecker
Pulmonary metastasectomy (PM) is routinely performed in colorectal cancer (CRC) patients with oligometastatic spreading to the lungs. Patients with an aggressive tumor phenotype should be excluded from PM, since its benefit is outweighed by early tumor recurrence and impaired prognosis. Expression of PD-1 and its ligands are prognostic factors in a variety of primary tumors. However, their impact on patients' outcome in the setting of PM for CRC has not been evaluated before. 53 CRC patients with pulmonary metastases receiving PM with curative intent were included in this study...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28922454/surgery-for-t4-lung-cancer-invading-the-thoracic-aorta-do-we-push-the-limits
#10
Giuseppe Marulli, Erino A Rendina, Walter Klepetko, Reinhold Perkmann, Davide Zampieri, Giulio Maurizi, Thomas Klikovits, Francesco Zaraca, Federico Venuta, Egle Perissinotto, Federico Rea
BACKGROUND: Few investigators have described en bloc resection of non-small cell lung cancer (NSCLC) invading the aorta. AIM OF STUDY: Analysis of outcome and prognostic factors for en bloc resections of NSCLC invading the aorta. METHODS: Thirty-five patients (27 males, 8 females; mean age 63 ± 8.6 years) were operated between 1994 and 2015 in four European Centers. HISTOLOGY: 12 (34.3%) squamous cell carcinoma, and 6 (17...
September 18, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28916219/take-a-deep-breath-and-everything-will-be-all-right%C3%A2
#11
EDITORIAL
Konrad Hoetzenecker, Walter Klepetko
No abstract text is available yet for this article.
August 17, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28870398/selective-lobar-exclusion-by-venous-clamping-during-ex%C3%A2-vivo-lung-perfusion
#12
Thomas Schweiger, Alberto Benazzo, Gyoergy Lang, José Ramon Matilla, Walter Klepetko
No abstract text is available yet for this article.
June 15, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28840012/extracorporeal-support-in-airway-surgery
#13
REVIEW
Konrad Hoetzenecker, Walter Klepetko, Shaf Keshavjee, Marcelo Cypel
Extracorporeal life support (ECLS) is increasingly used for major airway surgery. It facilitates complex reconstructions and maintains gas exchange during endoscopic procedures in patients with critical airway obstruction. ECLS offers the advantage of an uncluttered surgical field and eliminates the need for crossing ventilation tubes, thus, making precise surgical dissection easier. ECLS is currently used for hemodynamic and respiratory support in lung transplantation as well as extended tumor resections with an acceptable risk profile...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28838435/launching-the-hungarian-lung-transplantation-program
#14
F Rényi-Vámos, P Radeczky, B Gieszer, Á Ghimessy, K Czebe, K Török, B Döme, J Elek, W Klepetko, G Lang, I Madurka
The first successful lung transplantation was done in 1963 by James Hardy in the United States. The Vienna Lung Transplant program was launched in 1989 by Professor Walter Klepetko, and in 1996 lung transplantation became available in this center also for Hungarian patients. By 2013, conditions for full-scale Hungarian lung transplantation program were ripe. The Hungarian government invested 3 million Euros for infrastructural developments that made the operation and the perioperative care available. Besides funding, the professional training of medical personnel was also essential for this program to start...
September 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28740684/pediatric-airway-surgery
#15
REVIEW
Konrad Hoetzenecker, Thomas Schweiger, Doris Maria Denk-Linnert, Walter Klepetko
The management of pediatric airway pathology can be challenging and requires a dedicated team, consisting of thoracic surgeons, phoniatricians, logopedics, pediatricians and anesthetists. It necessitates a tailored treatment approach for each individual patient in order to address the minor variances that exist between cases. The majority of pediatric airway problems are a sequela of prematurity and prolonged post-partal intubation/tracheostomy. Surgical repair is often complicated by additional malformation or severe comorbidities...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740645/immunosuppression-after-lung-transplantation-the-search-for-the-holy-grail-continues
#16
EDITORIAL
Stefan Schwarz, Peter Jaksch, Walter Klepetko, Konrad Hoetzenecker
No abstract text is available yet for this article.
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740204/safety-and-tolerability-of-topically-administered-autologous-apoptotic-pbmc-secretome-aposec-in-dermal-wounds-a-randomized-phase-1-trial-marsyas-i%C3%AF
#17
Elisabeth Simader, Denise Traxler, Mohammad Mahdi Kasiri, Helmut Hofbauer, Michael Wolzt, Christoph Glogner, Angela Storka, Michael Mildner, Ghazaleh Gouya, Alexandra Geusau, Carola Fuchs, Claudia Eder, Alexandra Graf, Michaela Schaden, Bahar Golabi, Marie-Bernadette Aretin, Susanne Suessner, Christian Gabriel, Walter Klepetko, Erwin Tschachler, Hendrik Jan Ankersmit
Developing effective therapies against chronic wound healing deficiencies is a global priority. Thus we evaluated the safety of two different doses of topically administered autologous APOSEC, the secretome of apoptotic peripheral blood mononuclear cells (PBMCs), in healthy male volunteers with artificial dermal wounds. Ten healthy men were enrolled in a single-center, randomized, double-blinded, placebo-controlled phase 1 trial. Two artificial wounds at the upper arm were generated using a 4-mm punch biopsy...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729471/hypoxic-vascular-response-and-ventilation-perfusion-matching-in-end-stage-copd-may-depend-on-p22phox
#18
Chandran Nagaraj, Christoph Tabeling, Bence M Nagy, Pritesh P Jain, Leigh M Marsh, Rita Papp, Michael Pienn, Martin Witzenrath, Bahil Ghanim, Walter Klepetko, E Kenneth Weir, Stefan Heschl, Grazyna Kwapiszewska, Andrea Olschewski, Horst Olschewski
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease in which the amount of emphysema and airway disease may be very different between individuals, even in end-stage disease. Emphysema formation may be linked to the involvement of the small pulmonary vessels. The NAPDH oxidase (Nox) family is emerging as a key disease-related factor in vascular diseases, but currently its role in hypoxia-induced pulmonary remodelling in COPD remains unclear.Here we investigate the role of p22phox, a regulatory subunit of Nox, in COPD lungs, hypoxic pulmonary vasoconstriction (HPV), hypoxia-induced pulmonary vascular remodelling and pulmonary hypertension...
July 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28705908/importance-of-kynurenine-in-pulmonary-hypertension
#19
Bence M Nagy, Chandran Nagaraj, Andreas Meinitzer, Neha Sharma, Rita Papp, Vasile Foris, Bahil Ghanim, Grazyna Kwapiszewska, Gabor Kovacs, Walter Klepetko, Thomas R Pieber, Harald Mangge, Horst Olschewski, Andrea Olschewski
The tryptophan metabolite kynurenine is significantly increased in pulmonary arterial hyper-tension (PAH) patients, and it is a potent vasodilator of systemic arteries. Our aim was to in-vestigate the role of kynurenine in the pulmonary circulation. Serum tryptophan, kynurenine and kynurenic-acid levels were measured in 20 idiopathic PAH (IPAH) patients, 20 healthy controls and 20 patients with chronic lung disease or meta-bolic syndrome without-PH. Laser-dissected pulmonary arteries from IPAH and control lungs were tested for the expression of IDO, the rate-limiting enzyme for the conversion from tryptophan to kynurenine...
July 13, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28514756/elevated-crp-levels-predict-poor-outcome-and-tumor-recurrence-in-patients-with-thymic-epithelial-tumors-a-pro-and-retrospective-analysis
#20
Stefan Janik, Christine Bekos, Philipp Hacker, Thomas Raunegger, Bahil Ghanim, Elisa Einwallner, Lucian Beer, Walter Klepetko, Leonhard Müllauer, Hendrik J Ankersmit, Bernhard Moser
OBJECTIVE: Scarce information exists on the pathogenesis of thymic epithelial tumors (TETs), comprising thymomas, thymic carcinomas (TCs) and neuroendocrine tumors. C-reactive protein (CRP) increases during certain malignancies. We aimed to investigate the clinical relevance of CRP in patients with TETs. RESULTS: Pretreatment CRP serum concentrations were significantly elevated in patients with TETs, particularly TCs and metastatic TETs. After complete tumor resection CRP serum concentrations were decreased (p = 0...
July 18, 2017: Oncotarget
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