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Quorum sensing

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https://www.readbyqxmd.com/read/28338676/dirhamnolipids-secreted-from-pseudomonas-aeruginosa-modify-anjpegungal-susceptibility-of-aspergillus-fumigatus-by-inhibiting-%C3%AE-1-3-glucan-synthase-activity
#1
Benoit Briard, Vero Rasoldier, Perrine Bomme, Noureddine ElAouad, Catherine Guerreiro, Pierre Chassagne, Laetitia Muszkieta, Jean-Paul Latgé, Laurence Mulard, Anne Beauvais
Pseudomonas aeruginosa and Aspergillus fumigatus are the two microorganisms responsible for most of the chronic infections in cystic fibrosis patients. P. aeruginosa is known to produce quorum-sensing controlled rhamnolipids during chronic infections. Here we show that the dirhamnolipids secreted from P. aeruginosa (i) induce A. fumigatus to produce an extracellular matrix, rich in galactosaminogalactan, 1,8-dihydroxynaphthalene (DHN)- and pyo-melanin, surrounding their hyphae, which facilitates P. aeruginosa binding and (ii) inhibit A...
March 24, 2017: ISME Journal
https://www.readbyqxmd.com/read/28335447/transcriptomic-complexity-of-aspergillus-terreus-velvet-gene-family-under-the-influence-of-butyrolactone-i
#2
Elina K Palonen, Sheetal Raina, Annika Brandt, Jussi Meriluoto, Tajalli Keshavarz, Juhani T Soini
Filamentous fungi of the Ascomycota phylum are known to contain a family of conserved conidiation regulating proteins with distinctive velvet domains. In Aspergilli, this velvet family includes four proteins, VeA, VelB, VelC and VosA, and is involved in conidiation and secondary metabolism along with a global regulator LaeA. In A. terreus, the overexpression of LaeA has been observed to increase the biogenesis of the pharmaceutically-important secondary metabolite, lovastatin, while the role of the velvet family has not been studied...
March 14, 2017: Microorganisms
https://www.readbyqxmd.com/read/28334017/genome-wide-rnai-selection-identifies-a-regulator-of-transmission-stage-enriched-gene-families-and-cell-type-differentiation-in-trypanosoma-brucei
#3
Eva Rico, Alasdair Ivens, Lucy Glover, David Horn, Keith R Matthews
Trypanosoma brucei, causing African sleeping-sickness, exploits quorum-sensing (QS) to generate the 'stumpy forms' necessary for the parasite's transmission to tsetse-flies. These quiescent cells are generated by differentiation in the bloodstream from proliferative slender forms. Using genome-wide RNAi selection we screened for repressors of transmission stage-enriched mRNAs in slender forms, using the stumpy-elevated ESAG9 transcript as a model. This identified REG9.1, whose RNAi-silencing alleviated ESAG9 repression in slender forms and tsetse-midgut procyclic forms...
March 23, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28331600/bacterial-cell-to-cell-signaling-promotes-the-evolution-of-resistance-to-parasitic-bacteriophages
#4
Pierre Moreau, Stephen P Diggle, Ville-Petri Friman
The evolution of host-parasite interactions could be affected by intraspecies variation between different host and parasite genotypes. Here we studied how bacterial host cell-to-cell signaling affects the interaction with parasites using two bacteria-specific viruses (bacteriophages) and the host bacterium Pseudomonas aeruginosa that communicates by secreting and responding to quorum sensing (QS) signal molecules. We found that a QS-signaling proficient strain was able to evolve higher levels of resistance to phages during a short-term selection experiment...
March 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28330295/biomass-derived-molecules-modulate-the-behavior-of-streptomyces-coelicolor-for-antibiotic-production
#5
Shashi Kant Bhatia, Bo-Rahm Lee, Ganesan Sathiyanarayanan, Hun Seok Song, Junyoung Kim, Jong-Min Jeon, Jeong-Jun Yoon, Jungoh Ahn, Kyungmoon Park, Yung-Hun Yang
Various chemicals, i.e., furfural, vanillin, 4-hydroxybenzaldehyde and acetate produced during the pretreatment of biomass affect microbial fermentation. In this study, effect of vanillin, 4-hydroxybenzaldehyde and acetate on antibiotic production in Streptomyces coelicolor is investigated. IC 50 value of vanillin, 4-hydroxybenzaldehyde and acetate was recorded as 5, 11.3 and 115 mM, respectively. Vanillin was found as a very effective molecule, and it completely abolished antibiotic (undecylprodigiosin and actinorhodin) production at 1 mM concentration, while 4-hydroxybenzaldehyde and acetate have little effect...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330090/piper-betle-leaf-extract-affects-the-quorum-sensing-and-hence-virulence-of-pseudomonas-aeruginosa-pao1
#6
Siraj Datta, Debanjan Jana, Tilak Raj Maity, Aveek Samanta, Rajarshi Banerjee
Quorum sensing (QS) plays an important role in virulence of Pseudomonas aeruginosa, blocking of QS ability are viewed as viable antimicrobial chemotherapy and which may prove to be a safe anti-virulent drug. Bioactive components from Piper betle have been reported to possess antimicrobial ability. This study envisages on the anti-QS properties of ethanolic extract of P. betle leaf (PbLE) using P. aeruginosa PAO1 as a model organism. A marked reduction in swarming, swimming, and twitching ability of the bacteria is demonstrated in presence of PbLE...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329720/in-vitro-activity-of-farnesol-against-vaginal-lactobacillus-spp
#7
Fengjuan Wang, Zhaohui Liu, Dai Zhang, Xiaoxi Niu
OBJECTIVE: Farnesol, a quorum-sensing molecule in Candida albicans, can affect the growth of certain microorganisms. The objective of this study was to evaluate the in vitro activity of farnesol against vaginal Lactobacillus spp., which play a crucial role in the maintenance of vaginal health. METHODS: Growth and metabolic viability of vaginal Lactobacillus spp. incubated with different concentrations of farnesol were determined by measuring the optical density of the cultures and with the MTT assay...
March 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28328989/quorum-sensing-network-in-clinical-strains-of-a-baumannii-aida-is-a-new-quorum-quenching-enzyme
#8
María López, Celia Mayer, Laura Fernández-García, Lucía Blasco, Andrea Muras, Federico Martín Ruiz, German Bou, Ana Otero, María Tomás
Acinetobacter baumannii is an important pathogen that causes nosocomial infections generally associated with high mortality and morbidity in Intensive Care Units (ICUs). Currently, little is known about the Quorum Sensing (QS)/Quorum Quenching (QQ) systems of this pathogen. We analyzed these mechanisms in seven clinical isolates of A. baumannii. Microarray analysis of one of these clinical isolates, Ab1 (A. baumannii ST-2_clon_2010), previously cultured in the presence of 3-oxo-C12-HSL (a QS signalling molecule) revealed a putative QQ enzyme (α/ß hydrolase gene, AidA)...
2017: PloS One
https://www.readbyqxmd.com/read/28328982/highlighting-of-quorum-sensing-lux-genes-and-their-expression-in-the-hydrothermal-vent-shrimp-rimicaris-exoculata-ectosymbiontic-community-possible-use-as-biogeographic-markers
#9
Simon Le Bloa, Lucile Durand, Valérie Cueff-Gauchard, Josiane Le Bars, Laure Taupin, Charlotte Marteau, Alexis Bazire, Marie-Anne Cambon-Bonavita
Rimicaris exoculata is a caridean shrimp that dominates the fauna at several hydrothermal vent sites of the Mid-Atlantic Ridge. It has two distinct and stable microbial communities. One of these epibiontic bacterial communities is located in the shrimp gut and has a distribution and role that are poorly understood. The second colonizes its enlarged gill chamber and is involved in host nutrition. It is eliminated after each molt, and has colonization processes reminiscent of those of a biofilm. The presence and expression of genes usually involved in quorum sensing (QS) were then studied...
2017: PloS One
https://www.readbyqxmd.com/read/28326143/posttranslational-isoprenylation-of-tryptophan-in-bacteria
#10
REVIEW
Masahiro Okada, Tomotoshi Sugita, Ikuro Abe
Posttranslational isoprenylation is generally recognized as a universal modification of the cysteine residues in peptides and the thiol groups of proteins in eukaryotes. In contrast, the Bacillus quorum sensing peptide pheromone, the ComX pheromone, possesses a posttranslationally modified tryptophan residue, and the tryptophan residue is isoprenylated with either a geranyl or farnesyl group at the gamma position to form a tricyclic skeleton that bears a newly formed pyrrolidine, similar to proline. The post-translational dimethylallylation of two tryptophan residues of a cyclic peptide, kawaguchipeptin A, from cyanobacteria has also been reported...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28326068/negative-regulation-of-violacein-biosynthesis-in-chromobacterium-violaceum
#11
Giulia Devescovi, Milan Kojic, Sonia Covaceuszach, Miguel Cámara, Paul Williams, Iris Bertani, Sujatha Subramoni, Vittorio Venturi
In Chromobacteium violaceum, the purple pigment violacein is under positive regulation by the N-acylhomoserine lactone CviI/R quorum sensing system and negative regulation by an uncharacterized putative repressor. In this study we report that the biosynthesis of violacein is negatively controlled by a novel repressor protein, VioS. The violacein operon is regulated negatively by VioS and positively by the CviI/R system in both C. violaceum and in a heterologous Escherichia coli genetic background. VioS does not regulate the CviI/R system and apart from violacein, VioS, and quorum sensing regulate other phenotypes antagonistically...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28323149/the-effect-of-tobramycin-incorporated-with-bismuth-ethanedithiol-loaded-on-niosomes-on-the-quorum-sensing-and-biofilm-formation-of-pseudomonas-aeruginosa
#12
Faeze Mahdiun, Shahla Mansouri, Payam Khazaeli, Rasoul Mirzaei
Pseudomonas aeruginosa is an opportunistic pathogen, enable of causing infections especially in immunocompromised patients. Recently many isolates developed multiple drug resistance, resulting in treatment failure in serious infections. In this study, the effect of tobramycin incorporated with bismuth-ethanedithiol loaded on niosomes on the quorum sensing and biofilm production by P. aeruginosa was evaluated. Thin layer hydration method with cholesterol (30%), Span 40 and Tween 40 were used to make niosomes...
March 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28321957/activity-of-exogenous-tyrosol-in-combination-with-caspofungin-and-micafungin-against-candida-parapsilosis-sessile-cells
#13
Renátó Kovács, Zoltán Tóth, Fruzsina Nagy, Lajos Daróczi, Aliz Bozó, László Majoros
AIMS: Fungal quorum sensing molecules may have an inhibitory effect as adjuvant against Candida biofilms. Therefore, in vitro activity of caspofungin and micafungin was evaluated against Candida parapsilosis biofilms in the presence of tyrosol. METHODS AND RESULTS: Interactions were assessed using fractional inhibitory concentration index (FICI) determination, metabolic activity-based time-kill experiments, and scanning electron microscopy. Tyrosol caused 1- to 16-fold and 2- to 32-fold decrease in median caspofungin and micafungin MICs, respectively...
March 21, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28320949/discovery-of-scmr-as-a-global-regulator-of-secondary-metabolism-and-virulence-in-burkholderia-thailandensis-e264
#14
Dainan Mao, Leah B Bushin, Kyuho Moon, Yihan Wu, Mohammad R Seyedsayamdost
Bacteria produce a diverse array of secondary metabolites that have been invaluable in the clinic and in research. These metabolites are synthesized by dedicated biosynthetic gene clusters (BGCs), which assemble architecturally complex molecules from simple building blocks. The majority of BGCs in a given bacterium are not expressed under normal laboratory growth conditions, and our understanding of how they are silenced is in its infancy. Here, we have addressed this question in the Gram-negative model bacterium Burkholderia thailandensis E264 using genetic, transcriptomic, metabolomic, and chemical approaches...
March 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28320314/quorum-sensing-of-streptococcus-mutans-is-activated-by-aggregatibacter-actinomycetemcomitans-and-by-the-periodontal-microbiome
#15
Szymon P Szafrański, Zhi-Luo Deng, Jürgen Tomasch, Michael Jarek, Sabin Bhuju, Manfred Rohde, Helena Sztajer, Irene Wagner-Döbler
BACKGROUND: The oral cavity is inhabited by complex microbial communities forming biofilms that can cause caries and periodontitis. Cell-cell communication might play an important role in modulating the physiologies of individual species, but evidence so far is limited. RESULTS: Here we demonstrate that a pathogen of the oral cavity, Aggregatibacter actinomycetemcomitans (A. act.), triggers expression of the quorum sensing (QS) regulon of Streptococcus mutans, a well-studied model organism for cariogenic streptococci, in dual-species biofilms grown on artificial saliva...
March 20, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28319101/a-vibrio-cholerae-autoinducer-receptor-pair-that-controls-biofilm-formation
#16
Kai Papenfort, Justin E Silpe, Kelsey R Schramma, Jian-Ping Cong, Mohammad R Seyedsayamdost, Bonnie L Bassler
Quorum sensing (QS) is a cell-cell communication process that enables bacteria to track cell population density and orchestrate collective behaviors. QS relies on the production and detection of, and the response to, extracellular signal molecules called autoinducers. In Vibrio cholerae, multiple QS circuits control pathogenesis and biofilm formation. Here, we identify and characterize a new QS autoinducer-receptor pair. The autoinducer is 3,5-dimethylpyrazin-2-ol (DPO). DPO is made from threonine and alanine, and its synthesis depends on threonine dehydrogenase (Tdh)...
March 20, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28316144/characterization-of-the-multiple-molecular-mechanisms-underlying-rsal-control-of-phenazine-1-carboxylic-acid-biosynthesis-in-the-rhizosphere-bacterium-pseudomonas-aeruginosa-pa1201
#17
Shuang Sun, Bo Chen, Zi-Jing Jin, Lian Zhou, Yun-Ling Fang, Chitti Thawai, Giordano Rampioni, Ya-Wen He
Phenazines are important secondary metabolites that have been found to affect a broad spectrum of organisms. Two almost identical gene clusters phz1 and phz2 are responsible for phenazines biosynthesis in the rhizobacterium Pseudomonas aeruginosa PA1201. Here we show that the transcriptional regulator RsaL is a potent repressor of phenazine-1-carboxylic acid (PCA) biosynthesis. RsaL negatively regulates phz1 expression and positively regulates phz2 expression via multiple mechanisms. First, RsaL binds to a 25-bp DNA region within the phz1 promoter to directly repress phz1 expression...
March 18, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28306511/phagebook-the-social-network
#18
Alexander P Hynes, Sylvain Moineau
Much like social networks are used to connect with friends or relatives, bacteria communicate with relatives through quorum sensing. Viruses, though, were thought to be asocial-until now. Erez et al. (2017) reveal that viruses are also sharing information with relatives.
March 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28303132/mycobacterium-abscessus-subsp-abscessus-is-capable-of-degrading-pseudomonas-aeruginosa-quinolone-signals
#19
Franziska S Birmes, Timo Wolf, Thomas A Kohl, Kai Rüger, Franz Bange, Jörn Kalinowski, Susanne Fetzner
Pseudomonas aeruginosa employs 2-heptyl-3-hydroxy-4(1H)-quinolone (the Pseudomonas quinolone signal, PQS) and 2-heptyl-4(1H)-quinolone (HHQ) as quorum sensing signal molecules, which contribute to a sophisticated regulatory network controlling the production of virulence factors and antimicrobials. We demonstrate that Mycobacterium abscessus(T) and clinical M. abscessus isolates are capable of degrading these alkylquinolone signals. Genome sequences of 50 clinical M. abscessus isolates indicated the presence of aqdRABC genes, contributing to fast degradation of HHQ and PQS, in M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28302774/complete-genome-sequence-of-streptococcus-pyogenes-emm14-js95-a-necrotizing-fasciitis-strain-isolated-in-israel
#20
Jacqueline L Y Chee, Miriam Ravins, Emanuel Hanski, Swaine L Chen
Here, we report the complete genome sequence of the Streptococcus pyogenes emm14 strain JS95, isolated from a patient with necrotizing fasciitis. The streptococcal invasion locus (sil), the first quorum-sensing system characterized in S. pyogenes, was identified in this strain.
March 16, 2017: Genome Announcements
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