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https://www.readbyqxmd.com/read/29346726/the-effect-of-dielectric-environment-on-doping-efficiency-in-colloidal-pbse-nanostructures
#1
Qinghua Zhao, Tianshuo Zhao, Jiacen Guo, Wenxiang Chen, Mingliang Zhang, Cherie R Kagan
Doping, as a central strategy to control free carrier type and concentration in semiconductor materials, suffers from low efficiency at the nanoscale, especially in systems having high permittivity (ϵ) and large Bohr radii, such as lead chalcogenide nanocrystals (NCs) and nanowires (NWs). Here, we study dielectric confinement effects on the doping efficiency of lead chalcogenides nanostructures by integrating PbSe NWs in the platform of field effect transistors (FETs). Elemental Pb or In or elemental Se is deposited by thermal evaporation to remotely n- or p-dope the NWs...
January 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29346675/in-search-of-the-best-xenogeneic-material-for-a-paediatric-conduit-an-experimental-study
#2
Irina Y Zhuravleva, Nataliya R Nichay, Yuriy Y Kulyabin, Tatyana P Timchenko, Alexander A Korobeinikov, Yuliya F Polienko, Svetlana S Shatskaya, Elena V Kuznetsova, Alexey V Voitov, Alexander V Bogachev-Prokophiev, Alexander M Karaskov
OBJECTIVES: The development of calcification-resistant bioprosthetic materials is a very important challenge for paediatric surgery. The subcutaneous implantation in rats is the well-known first-stage model for this kind of research. Using this model, we aimed to compare calcification of the porcine aortic wall and bovine pericardium and jugular vein wall cross-linked with glutaraldehyde (GA) and ethylene glycol diglycidyl ether (DE). We also determined the efficacy of DE-preserved tissue modification with 2-(2-carboxyethylamino)ethylidene-1,1-bisphosphonic acid (CEABA)...
January 15, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29346567/epithelial-grafting-of-a-decellularized-whole-tracheal-segment-an-in-vivo-experimental-model
#3
Margot Den Hondt, Bart M Vanaudenaerde, Eric K Verbeken, Jan J Vranckx
OBJECTIVES: Prerequisites for successful trachea transplantation include the use of a biocompatible construct, submucosal vascularization and an epithelial covering. Implantation of non-epithelialized tracheal scaffolds may lead to stenosis. However, epithelial grafting or seeding can only be attempted onto a well-vascularized submucosal bed. Our aim was to investigate a method to prevent stenosis during prelamination of non-epithelialized, gently decellularized rabbit tracheae and to evaluate whether grafting of revascularized constructs with buccal mucosa is feasible...
January 15, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29346560/aggregation-and-travelling-wave-dynamics-in-a-two-population-model-of-cancer-cell-growth-and-invasion
#4
Vasiliki Bitsouni, Dumitru Trucu, Mark A J Chaplain, Raluca Eftimie
Cells adhere to each other and to the extracellular matrix (ECM) through protein molecules on the surface of the cells. The breaking and forming of adhesive bonds, a process critical in cancer invasion and metastasis, can be influenced by the mutation of cancer cells. In this paper, we develop a nonlocal mathematical model describing cancer cell invasion and movement as a result of integrin-controlled cell-cell adhesion and cell-matrix adhesion, for two cancer cell populations with different levels of mutation...
January 15, 2018: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/29346451/an-approach-for-predicting-the-compressive-strength-of-cement-based-materials-exposed-to-sulfate-attack
#5
Huaicheng Chen, Chunxiang Qian, Chengyao Liang, Wence Kang
In this paper, a support vector machine (SVM) model which can be used to predict the compressive strength of mortars exposed to sulfate attack was established. An accelerated corrosion test was applied to collect compressive strength data. For predicting the compressive strength of mortars, a total of 638 data samples obtained from experiment was chosen as a dataset to establish a SVM model. The values of the coefficient of determination, the mean absolute error, the mean absolute percentage error and the root mean square error were used for evaluating the predictive accuracy...
2018: PloS One
https://www.readbyqxmd.com/read/29346372/ceramides-in-tracheal-aspirates-of-preterm-infants-marker-for-bronchopulmonary-dysplasia
#6
Esther van Mastrigt, Salomé Zweekhorst, Bas Bol, Jeroen Tibboel, Joost van Rosmalen, Janneke N Samsom, André A Kroon, Johan C de Jongste, Irwin K M Reiss, Martin Post, Mariëlle W Pijnenburg
BACKGROUND: In an experimental mouse model we showed that ceramides play a role in the pathogenesis of bronchopulmonary dysplasia (BPD) and are a potential target for therapeutic intervention. We investigated whether ceramides are detectable in tracheal aspirates (TAs) of preterm infants and differ between infants with or without BPD. METHODS: Infants born ≤ 32 weeks of gestational age in need of mechanical ventilation in the first week of life were included. TAs were obtained directly after intubation and at day 1, 3, 5, 7, and 14...
2018: PloS One
https://www.readbyqxmd.com/read/29346371/identification-of-novel-leishmanicidal-molecules-by-virtual-and-biochemical-screenings-targeting-leishmania-eukaryotic-initiation-factor-4a
#7
Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi, Ons Zakraoui, Guillaume Bouvier, Khadija Essafi-Benkhadir, Josette Banroques, Nathan Desdouits, Hélène Munier-Lehmann, Mourad Barhoumi, N Kyle Tanner, Michael Nilges, Arnaud Blondel, Ikram Guizani
Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on public health. The identification of novel drugs and targets constitutes a research priority. For that purpose we used Leishmania infantum initiation factor 4A (LieIF), an essential translation initiation factor that belongs to the DEAD-box proteins family, as a potential drug target. We modeled its structure and identified two potential binding sites. A virtual screening of a diverse chemical library was performed for both sites...
January 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346320/c-phycocyanin-and-phycocyanobilin-as-remyelination-therapies-for-enhancing-recovery-in-multiple-sclerosis-and-ischemic-stroke-a-preclinical-perspective
#8
REVIEW
Giselle Pentón-Rol, Javier Marín-Prida, Viviana Falcón-Cama
Myelin loss has a crucial impact on behavior disabilities associated to Multiple Sclerosis (MS) and Ischemic Stroke (IS). Although several MS therapies are approved, none of them promote remyelination in patients, limiting their ability for chronic recovery. With no available therapeutic options, enhanced demyelination in stroke survivors is correlated with a poorer behavioral recovery. Here, we show the experimental findings of our group and others supporting the remyelinating effects of C-Phycocyanin (C-PC), the main biliprotein of Spirulina platensis and its linked tetrapyrrole Phycocyanobilin (PCB), in models of these illnesses...
January 18, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/29346225/validating-lung-models-using-the-asl-5000-breathing-simulator
#9
Amanda Dexter, Neil McNinch, Destiny Kaznoch, Teresa A Volsko
OBJECTIVE: This study sought to validate pediatric models with normal and altered pulmonary mechanics. METHODS: PubMed and CINAHL databases were searched for studies directly measuring pulmonary mechanics of healthy infants and children, infants with severe bronchopulmonary dysplasia and neuromuscular disease. The ASL 5000 was used to construct models using tidal volume (VT), inspiratory time (TI), respiratory rate, resistance, compliance, and esophageal pressure gleaned from literature...
January 17, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29346113/uncertainty-in-limb-configuration-makes-minimal-contribution-to-errors-between-observed-and-predicted-forces-in-a-musculoskeletal-model-of-the-rat-hindlimb
#10
Qi Wei, Dinesh K Pai, Matthew C Tresch
Subject-specific musculoskeletal models are increasingly used in biomedical applications to predict endpoint forces due to muscle activation, matching predicted forces to experimentally observed forces at a specific limb configuration. However, it is difficult to precisely measure the limb configuration at which these forces are observed. The consequent uncertainty in limb configuration might contribute to errors in model predictions. We therefore evaluated how uncertainties in limb configuration measurement contributed to errors in force prediction, using data from in vivo measurements in the rat hindlimb...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29346112/numerical-model-reduction-for-the-prediction-of-interface-pressure-applied-by-compression-bandages-on-the-lower-leg
#11
Fanette Chassagne, Jerome Molimard, Reynald Convert, Pascal Giraux, Pierre Badel
OBJECTIVE: To develop a new method for the prediction of interface pressure applied by medical compression bandages. METHODS: A finite element simulation of bandage application was designed, based on patient-specific leg geometries. For personalized interface pressure prediction, a model reduction approach was proposed, which included the parametrization of the leg geometry. Pressure values computed with this reduced model were then confronted to experimental pressure values...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29346104/characterization-and-modeling-of-tissue-thermal-conductivity-during-an-electrosurgical-joining-process
#12
Che-Hao Yang, Wei Li, Roland K Chen
Electrosurgical vessel joining is commonly performed in surgical procedures to maintain hemostasis. This process requires elevated temperature to denature the tissue and while compression is applied, the tissue can be joined together. The elevated temperature can cause thermal damages to the surrounding tissues. In order to minimize these damages, it is critical to understand how the tissue properties change and how that affects the thermal spread. The purpose of this study is to investigate the changes of tissue thermal conductivity and how the changes correlate to thermal dose during the joining process...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29346098/region-based-prediction-for-image-compression-in-the-cloud
#13
Jean Begaint, Dominique Thoreau, Philippe Guillotel, Christine Guillemot
Thanks to the increasing number of images stored in the cloud, external image similarities can be leveraged to efficiently compress images by exploiting inter-images correlations. In this paper, we propose a novel image prediction scheme for cloud storage. Unlike current state-of-the-art methods, we use a semi-local approach to exploit inter-image correlation. The reference image is first segmented into multiple planar regions determined from matched local features and super-pixels. The geometric and photometric disparities between the matched regions of the reference image and the current image are then compensated...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29346096/iterative-graph-seeking-for-object-tracking
#14
Dawei Du, Longyin Wen, Honggang Qi, Qingming Huang, Qi Tian, Siwei Lyu
To effectively solve the challenges in object tracking, such as large deformation and severe occlusion, many existing methods use graph-based models to capture target part relations, and adopt a sequential scheme of target part selection, part matching, and state estimation. However, such methods have two major drawbacks: 1) inaccurate part selection leads to performance deterioration of part matching and state estimation and 2) there are insufficient effective global constraints for local part selection and matching...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29346094/reweighted-low-rank-matrix-analysis-with-structural-smoothness-for-image-denoising
#15
Hengyou Wang, Yigang Cen, Zhiquan He, Zhihai He, Ruizhen Zhao, Fengzhen Zhang
In this paper, we develop a new low-rank matrix recovery algorithm for image denoising. We incorporate the total variation (TV) norm and the pixel range constraint into the existing reweighted low-rank matrix analysis to achieve structural smoothness and to significantly improve quality in the recovered image. Our proposed mathematical formulation of the low-rank matrix recovery problem combines the nuclear norm, TV norm, and norm, thereby allowing us to exploit the low-rank property of natural images, enhance the structural smoothness, and detect and remove large sparse noise...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29346088/intense-olfactory-stimulation-blocks-seizures-in-an-experimental-model-of-epilepsy
#16
Polianna Delfino-Pereira, Poliana Bertti-Dutra, Eduardo Henrique de Lima Umeoka, José Antônio Cortes de Oliveira, Victor Rodrigues Santos, Artur Fernandes, Simone Saldanha Marroni, Flávio Del Vecchio, Norberto Garcia-Cairasco
There are reports of patients whose epileptic seizures are prevented by means of olfactory stimulation. Similar findings were described in animal models of epilepsy, such as the electrical kindling of amygdala, where olfactory stimulation with toluene (TOL) suppressed seizures in most rats, even when the stimuli were 20% above the threshold to evoke seizures in already kindled animals. The Wistar Audiogenic Rat (WAR) strain is a model of tonic-clonic seizures induced by acute acoustic stimulation, although it also expresses limbic seizures when repeated acoustic stimulation occurs - a process known as audiogenic kindling (AK)...
January 12, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29346010/identification-and-correction-of-additive-and-multiplicative-spatial-biases-in-experimental-high-throughput-screening
#17
Bogdan Mazoure, Iurie Caraus, Robert Nadon, Vladimir Makarenkov
Data generated by high-throughput screening (HTS) technologies are prone to spatial bias. Traditionally, bias correction methods used in HTS assume either a simple additive or, more recently, a simple multiplicative spatial bias model. These models do not, however, always provide an accurate correction of measurements in wells located at the intersection of rows and columns affected by spatial bias. The measurements in these wells depend on the nature of interaction between the involved biases. Here, we propose two novel additive and two novel multiplicative spatial bias models accounting for different types of bias interactions...
January 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29345906/prediction-of-hot-spots-at-myeloid-cell-leukemia-1-inhibitors-interface-using-energy-estimation-and-alanine-scanning-mutagenesis
#18
Parthiban Marimuthu, Kalaimathy Singaravelu
Myeloid cell leukemia 1 (Mcl1) is an anti-apoptotic protein that plays central role in apoptosis regulation. Also, Mcl1 has the potency to resist apoptotic cues resulting in up-regulation and cancer cell protection. A molecular probe that has the potential to specifically target Mcl1, and thereby provoke its down-regulatory activity is very essential. The aim of the current study is to probe the internal conformational dynamics of protein motions and potential binding mechanism in response to a series of picomolar range Mcl1 inhibitors using explicit-solvent molecular dynamics (MD) simulations...
January 18, 2018: Biochemistry
https://www.readbyqxmd.com/read/29345841/effects-of-high-impact-exercise-on-the-physical-properties-of-bones-of-ovariectomized-rats-fed-to-a-high-protein-diet
#19
Roberta Carminati Shimano, Gabriela Rezende Yanagihara, Ana Paula Macedo, Jessica Suzuki Yamanaka, Antônio Carlos Shimano, João Manuel R S Tavares, João Paulo Mardegan Issa
The aim of this study was to evaluate the effects of high-impact physical exercise as a prophylactic and therapeutic means in osteopenic bones of rats submitted to ovariectomy and protein diet intake. A total of 64 Wistar rats were divided into eight groups (n=8 each), being: OVX, ovx, standard diet and sedentary; OVXE, ovx, standard diet and jump; OVXP, ovx, high-protein diet and sedentary; and OVXEP, ovx, high-protein diet and jump; SH, sham, standard diet and sedentary; SHE, sham, standard diet and jump; SHP, sham, high-protein diet and sedentary; and SHEP, sham, high-protein-diet and jump...
January 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29345546/enhanced-biosorption-of-transition-metals-by-living-chlorella-vulgaris-immobilized-in-ca-alginate-beads
#20
Ashfaq Ahmad, A H Bhat, Azizul Buang
In this study freely suspended and Ca-alginate immobilized C. vulgaris cells were used for the biosorption of Fe(II), Mn(II), and Zn(II) ions, from the aqueous solution. Experimental data showed that biosorption capacity of algal cells was strongly dependent on the operational condition such as pH, initial metal ions concentration, dosages, contact time and temperature. The maximum biosorption of Fe(II) 43.43, Mn(II) 40.98 and Zn(II) 37.43 mg/g was achieved with Ca-alginate immobilized algal cells at optimum pH of 6...
January 18, 2018: Environmental Technology
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