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https://www.readbyqxmd.com/read/29036899/targeting-strategies-for-the-combination-treatment-of-cancer-using-drug-delivery-systems
#1
REVIEW
Janel Kydd, Rahul Jadia, Praveena Velpurisiva, Aniket Gad, Shailee Paliwal, Prakash Rai
Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy treatment-due to the hostile tumor microenvironment-that create a significant challenge for effective therapeutic regimens. Multidrug resistance, collateral toxicity to normal cells, and detrimental systemic side effects present significant obstacles, necessitating alternative and safer treatment strategies. Traditional administration of chemotherapeutics has demonstrated minimal success due to the non-specificity of action, uptake and rapid clearance by the immune system, and subsequent metabolic alteration and poor tumor penetration...
October 14, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/29036558/methrafo-medip-seq-methylation-estimate-using-a-random-forest-regressor
#2
Jun Ding, Ziv Bar-Joseph
Motivation: Profiling of genome wide DNA methylation is now routinely performed when studying development, cancer and several other biological processes. Although Whole genome Bisulfite Sequencing provides high-quality methylation measurements at the resolution of nucleotides, it is relatively costly and so several studies have used alternative methods for such profiling. One of the most widely used low cost alternatives is MeDIP-Seq. However, MeDIP-Seq is biased for CpG enriched regions and thus its results need to be corrected in order to determine accurate methylation levels...
July 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036440/analysis-and-prediction-of-protein-folding-energy-changes-upon-mutation-by-element-specific-persistent-homology
#3
Zixuan Cang, Guo-Wei Wei
Motivation: Site directed mutagenesis is widely used to understand the structure and function of biomolecules. Computational prediction of mutation impacts on protein stability offers a fast, economical and potentially accurate alternative to laboratory mutagenesis. Most existing methods rely on geometric descriptions, this work introduces a topology based approach to provide an entirely new representation of mutation induced protein stability changes that could not be obtained from conventional techniques...
July 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036057/decomposition-of-the-total-wave-aberration-in-generalized-optical-systems
#4
Mateusz Oleszko, Ralf Hambach, Herbert Gross
The increasing use of freeform optical surfaces raises the demand for optical design tools developed for generalized systems. In the design process, surface-by-surface aberration contributions are of special interest. The expansion of the wave aberration function into field- and pupil-dependent coefficients is an analytical method used for that purpose. An alternative numerical approach utilizing data from the trace of multiple ray sets is proposed. The optical system is divided into segments of the optical path measured along the chief ray...
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29036023/percutaneous-mesh-expansion-pme-a-regenerative-wound-closure-alternative
#5
Kimberly S Khouri, Eufemiano Cardoso, Roger K Khouri
BACKGROUND: Puncture wounds in the 1-mm range usually heal without scars. Stacking rows of these punctures offers a scarless method to generate tissue by mesh expansion. We developed a percutaneous mesh expansion (PME) procedure and present our experience for its wound closure application. METHODS: Over a six-year period we applied PME to 65 consecutive patients 58-101 years-old (mean, 72) with 67 full thickness calvarial defects 2.5x3-7x8cm (mean, 14cm2) that would have all required flaps for closure...
October 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29035839/insights-into-protein-misfolding-and-aggregation-enabled-by-solid-state-nmr-spectroscopy
#6
REVIEW
Patrick C A van der Wel
The aggregation of proteins and peptides into a variety of insoluble, and often non-native, aggregated states plays a central role in many devastating diseases. Analogous processes undermine the efficacy of polypeptide-based biological pharmaceuticals, but are also being leveraged in the design of biologically inspired self-assembling materials. This Trends article surveys the essential contributions made by recent solid-state NMR (ssNMR) studies to our understanding of the structural features of polypeptide aggregates, and how such findings are informing our thinking about the molecular mechanisms of misfolding and aggregation...
October 4, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/29035804/green-electrospun-and-crosslinked-poly-vinyl-alcohol-poly-acrylic-acid-composite-membranes-for-antibacterial-effective-air-filtration
#7
Miaomiao Zhu, Dawei Hua, Hui Pan, Fei Wang, Bella Manshian, Stefaan J Soenen, Ranhua Xiong, Chaobo Huang
Air pollution has become a major environmental concern given the ever increasing levels of particulate matter (PM) and the increased in treatment-resistant bacterial and viral strains. Major efforts are therefore required into the development of air filtration and purification technology as well as novel, alternative antiviral and antibacterial treatment modalities. Here, we report an environmentally friendly method for the generation of multifunctional poly(vinyl alcohol)/poly(acrylic acid) (PVA-PAA) composite membranes via green electrospinning and thermal crosslinking...
October 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29035455/evaluation-of-a-magnetic-cellulose-based-dna-extraction-system-to-improve-the-performance-of-hybribio-human-papillomavirus-genotyping-and-screening-tests-for-cervical-swab-samples
#8
Zengge Wang, Yulin Zhou, Jun Ren, Zhongmin Xia, Qiwei Guo
BACKGROUND: To ensure the accuracy of clinical human papillomavirus (HPV) testing, the nucleic acid extraction procedure should be thoroughly evaluated for each clinical sample type. Therefore, we evaluated whether the MagCore® Automated Nucleic Acid Extraction system (MagCore system) could improve HybriBio HPV test performance for cervical swab samples. METHODS: We compared the performance of HybriBio HPV genotyping and screening tests using samples prepared with the MagCore system and Cell Lysis Kit, which was provided by the HPV test manufacturer...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035417/relative-performance-of-three-stream-bed-stability-indices-as-indicators-of-stream-health
#9
Paul C Kusnierz, Christopher M Holbrook
Bed stability is an important stream habitat attribute because it affects geomorphology and biotic communities. Natural resource managers desire indices of bed stability that can be used under a wide range of geomorphic conditions, are biologically meaningful, and are easily incorporated into sampling protocols. To eliminate potential bias due to presence of instream wood and increase precision of stability values, we modified a stream bed instability index (ISI) to include measurements of bankfull depth (d bf) and median particle diameter (D 50) only in riffles and increased the pebble count to decrease variability (i...
October 16, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29035311/modeling-of-interactions-between-the-zebrafish-hatching-enzyme-zhe1-and-a-series-of-metal-oxide-nanoparticles-nano-qsar-and-causal-analysis-of-inactivation-mechanisms
#10
Natalia Sizochenko, Danuta Leszczynska, Jerzy Leszczynski
The quantitative relationships between the activity of zebrafish ZHE1 enzyme and a series of experimental and physicochemical features of 24 metal oxide nanoparticles were revealed. Vital characteristics of the nanoparticles' structure were reflected using both experimental and theoretical descriptors. The developed quantitative structure-activity relationship model for nanoparticles (nano-QSAR) was capable of predicting the enzyme inactivation based on four descriptors: the hydrodynamic radius, mass density, the Wigner-Seitz radius, and the covalent index...
October 16, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29034909/a-universal-and-enzyme-free-immunoassay-platform-for-biomarker-detection-based-on-gold-nanoparticle-enumeration-with-a-dark-field-microscope
#11
Xi Wu, Tian Li, Guangyu Tao, Ruoyun Lin, Xiaojing Pei, Feng Liu, Na Li
Developing an enzyme-free, non-amplification strategy for biomarker detection with universality and easy implementation is of central importance in clinical diagnosis and therapeutic monitoring. Herein, we report for the first time a universal and enzyme-free magnetic bead-based sandwich-format immunoassay platform for biomarker detection by combining secondary antibody functionalized AuNPs and automatic AuNP counting readout. For the prostate specific antigen (PSA), the detection limit is found to be 1 ng mL(-1), and the spike recoveries (n = 3) with 10% fetal bovine serum are 113...
October 16, 2017: Analyst
https://www.readbyqxmd.com/read/29034527/age-of-onset-or-age-at-assessment-that-is-the-question-estimating-newly-incident-alcohol-drinking-and-rapid-transition-to-heavy-drinking-in-the-united-states-2002-2014
#12
Hui G Cheng, Catalina Lopez-Quintero, James C Anthony
Age-specific incidence estimates are important and useful facts in psychiatric epidemiology, but incidence estimation can be challenging. Methods artifacts are possible. In the United States, where the minimum legal drinking age is 21 years, recent cross-sectional field research on 12- to 25-year-olds applied conventional "age-at-assessment" approaches (AAA) for incidence estimation based on 12-month recall. Estimates disclosed unexpected nonlinear patterns in age-specific incidence estimates for both drinking onset and for transitioning from first drink to heavy drinking...
October 15, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29034516/identifying-gene-gene-interactions-using-penalized-tensor-regression
#13
Mengyun Wu, Jian Huang, Shuangge Ma
Gene-gene (G×G) interactions have been shown to be critical for the fundamental mechanisms and development of complex diseases beyond main genetic effects. The commonly adopted marginal analysis is limited by considering only a small number of G factors at a time. With the "main effects, interactions" hierarchical constraint, many of the existing joint analysis methods suffer from prohibitively high computational cost. In this study, we propose a new method for identifying important G×G interactions under joint modeling...
October 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29034484/dissecting-gene-environment-interactions-a-penalized-robust-approach-accounting-for-hierarchical-structures
#14
Cen Wu, Yu Jiang, Jie Ren, Yuehua Cui, Shuangge Ma
Identification of gene-environment (G × E) interactions associated with disease phenotypes has posed a great challenge in high-throughput cancer studies. The existing marginal identification methods have suffered from not being able to accommodate the joint effects of a large number of genetic variants, while some of the joint-effect methods have been limited by failing to respect the "main effects, interactions" hierarchy, by ignoring data contamination, and by using inefficient selection techniques under complex structural sparsity...
October 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29034451/cortical-light-scattering-during-interictal-epileptic-spikes-in-frontal-lobe-epilepsy-in-children-a-fast-optical-signal-and-electroencephalographic-study
#15
Mana Manoochehri, Mahdi Mahmoudzadeh, Emilie Bourel-Ponchel, Fabrice Wallois
OBJECTIVE: Interictal epileptic spikes (IES) represent a signature of the transient synchronous and excessive discharge of a large ensemble of cortical heterogeneous neurons. Epilepsy cannot be reduced to a hypersynchronous activation of neurons whose functioning is impaired, resulting on electroencephalogram (EEG) in epileptic seizures or IES. The complex pathophysiological mechanisms require a global approach to the interactions between neural synaptic and nonsynaptic, vascular, and metabolic systems...
October 16, 2017: Epilepsia
https://www.readbyqxmd.com/read/29034409/multi-criteria-analysis-for-municipal-solid-waste-management-in-a-brazilian-metropolitan-area
#16
Simone Machado Santos, Maisa Mendonça Silva, Renata Maciel Melo, Savia Gavazza, Lourdinha Florencio, Mario T Kato
The decision-making process involved in municipal solid waste management (MSWM) must consider more than just financial aspects, which makes it a difficult task in developing countries. The Recife Metropolitan Region (RMR) in the Northeast of Brazil faces a MSWM problem that has been ongoing since the 1970s, with no common solution. In order to direct short-term solutions, three MSWM alternatives were outlined for the RMR, considering the current and future situations, the time and cost involved and social/environmental criteria...
October 15, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29034081/renal-impairment-in-stroke-patients-a-comparison-between-the-haemorrhagic-and-ischemic-variants
#17
Pratyush Shrestha, Shalima Thapa, Shikher Shrestha, Subash Lohani, Suresh Bk, Oscar MacCormac, Lekhjung Thapa, Upendra Prasad Devkota
Background: Renal impairment is regularly seen in hospitalized stroke patients, affecting the outcome of patients, as well as causing difficulties in their management. A prospective cohort study was conducted to assess the trend of renal function in hospitalized ischemic and haemorrhagic stroke patients. The incidence of renal impairment in these subgroups, the contributing factors and the need for renal replacement in renal impaired patients was evaluated. Methods: Alternate day renal function testing was performed in hospitalized stroke patients...
2017: F1000Research
https://www.readbyqxmd.com/read/29034004/genetic-engineering-of-the-calvin-cycle-toward-enhanced-photosynthetic-co2-fixation-in-microalgae
#18
Bo Yang, Jin Liu, Xiaonian Ma, Bingbing Guo, Bin Liu, Tao Wu, Yue Jiang, Feng Chen
BACKGROUND: Photosynthetic microalgae are emerging as potential biomass feedstock for sustainable production of biofuels and value-added bioproducts. CO2 biomitigation through these organisms is considered as an eco-friendly and promising alternative to the existing carbon sequestration methods. Nonetheless, the inherent relatively low photosynthetic capacity of microalgae has hampered the practical use of this strategy for CO2 biomitigation applications. RESULTS: Here, we demonstrate the feasibility of improving photosynthetic capacity by the genetic manipulation of the Calvin cycle in the typical green microalga Chlorella vulgaris...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29033976/conffuse-high-confidence-fusion-gene-detection-across-tumor-entities
#19
Zhiqin Huang, David T W Jones, Yonghe Wu, Peter Lichter, Marc Zapatka
Background: Fusion genes play an important role in the tumorigenesis of many cancers. Next-generation sequencing (NGS) technologies have been successfully applied in fusion gene detection for the last several years, and a number of NGS-based tools have been developed for identifying fusion genes during this period. Most fusion gene detection tools based on RNA-seq data report a large number of candidates (mostly false positives), making it hard to prioritize candidates for experimental validation and further analysis...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29033780/evolutionary-musicology-meets-embodied-cognition-biocultural-coevolution-and-the-enactive-origins-of-human-musicality
#20
REVIEW
Dylan van der Schyff, Andrea Schiavio
Despite evolutionary musicology's interdisciplinary nature, and the diverse methods it employs, the field has nevertheless tended to divide into two main positions. Some argue that music should be understood as a naturally selected adaptation, while others claim that music is a product of culture with little or no relevance for the survival of the species. We review these arguments, suggesting that while interesting and well-reasoned positions have been offered on both sides of the debate, the nature-or-culture (or adaptation vs...
2017: Frontiers in Neuroscience
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