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https://www.readbyqxmd.com/read/29909465/anteromedial-femoral-neck-plate-with-cannulated-screws-for-the-treatment-of-irreducible-displaced-femoral-neck-fracture-in-young-patients-a-preliminary-study
#1
Linbo Zhuang, Lisheng Wang, Dongming Xu, Zhiyong Wang
BACKGROUNDS: Although most displaced femoral neck fractures of young patients can be repositioned successfully by closed reduction, there are still some can not repositioned successfully by this way and open reductions are required. This type of fracture was defined as irreducible displaced femoral neck fracture in this study. The purpose of this study was to introduce a new technique using anteromedial femoral neck plate with cannulated screws fixation by open reduction for the treatment of irreducible displaced femoral neck fractures in young patients...
June 16, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29909458/what-about-the-herb-a-new-metabolomics-approach-for-synthetic-cannabinoid-drug-testing
#2
Lubertus Bijlsma, Rubén Gil-Solsona, Félix Hernández, Juan Vicente Sancho
Synthetic cannabinoids (SCs) are consumed as legal alternative to cannabis and often allow passing drug-screening tests. Their rapid transience on the drug scene, combined with their mostly unknown metabolic profiles, creates a scenario with constantly moving analytical targets, making their monitoring and identification challenging. The development of fast screening strategies for SCs, not directly focused on their chemical structure, as an alternative to the commonly applied target acquisition methods, would be highly appreciated in forensic and public health laboratories...
June 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29909236/antiepileptic-drugs-as-analgesics-adjuvants-in-inflammatory-pain-current-preclinical-evidence
#3
REVIEW
Tomić Maja, Pecikoza Uroš, Micov Ana, Vučković Sonja, Stepanović-Petrović Radica
Inflammatory pain is the most common type of pain that is treated clinically. The use of currently available treatments (classic analgesics - NSAIDs, paracetamol and opioids) is limited by insufficient efficacy and/or side effects/tolerance development. Antiepileptic drugs (AEDs) are widely used in neuropathic pain treatment, but there is substantial preclinical evidence on their efficacy against inflammatory pain, too. In this review we focus on gabapentinoids (gabapentin and pregabalin) and dibenzazepine AEDs (carbamazepine, oxcarbazepine, and recently introduced eslicarbazepine acetate) and their potential for relieving inflammatory pain...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29908920/a-new-metastatic-lymph-node-classification-based-survival-predicting-model-in-patients-with-small-bowel-adenocarcinoma-a-derivation-and-validation-study
#4
Shan Wu, Jin-Nan Chen, Qing-Wei Zhang, Chao-Tao Tang, Xin-Tian Zhang, Ming-Yu Tang, Xiao-Bo Li, Zhi-Zheng Ge
BACKGROUND: Current methods of lymph node (LN) staging are controversial in predicting the survival of SBA. We aimed to develop an alternative LN-classification-based nomogram to individualize SBA prognosis. METHODS: Based on the data from the Surveillance, Epidemiology, and End Results (SEER) database of patients diagnosed with SBA between 2004 and 2014, we identified the cut-off points for the number of LNs examined and the number found to be metastatic using the K-adaptive partitioning (KAPS) algorithm...
June 13, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29908701/direct-analysis-of-vitamin-a-vitamin-e-carotenoids-chlorophylls-and-free-sterols-in-animal-and-vegetable-fats-in-a-single-normal-phase-liquid-chromatographic-run
#5
Rebeca Cruz, Susana Casal
The present method was optimized and validated to enable quantification of more than twenty compounds from four chemical classes of important lipid substances, including vitamin E and A derivatives, sterols and chlorophylls. After lipid dissolution in the mobile phase, chromatographic separation is accomplished with the newest generation of ultrapure unbounded fully porous silica particles and, finally, target analytes are quantified by diode-array tandem fluorescence detection. A broad working range was achieved for most compounds (r2 > 0...
June 12, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29908516/analysis-of-volatiles-in-fire-debris-by-combination-of-activated-charcoal-strips-acs-and-automated-thermal-desorption-gas-chromatography-mass-spectrometry-atd-gc-ms
#6
Marie Martin Fabritius, Alain Broillet, Stefan König, Wolfgang Weinmann
Adsorption of volatiles in gaseous phase to activated charcoal strip (ACS) is one possibility for the extraction and concentration of ignitable liquid residues (ILRs) from fire debris in arson investigations. Besides liquid extraction using carbon dioxide or hexane, automated thermo-desorption can be used to transfer adsorbed residues to direct analysis by gas chromatography-mass spectrometry (GC-MS). We present a fire debris analysis work-flow with headspace adsorption of volatiles onto ACS and subsequent automated thermo-desorption (ATD) GC-MS analysis...
June 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29908206/a-real-time-loop-mediated-isothermal-amplification-method-for-rapid-detection-of-lawsonia-intracellularis-in-porcine-fecal-samples
#7
Yanan Li, Jianchang Wang, Jinfeng Wang, Libing Liu, Ruoxi Zhang, Ruihan Shi, Qingan Han, Jiguo Sun, Wanzhe Yuan
Porcine proliferative enteritis is a common diarrheal disease characterized by thickening of the intestinal mucosa in swine due to enterocyte proliferation, which is caused by Lawsonia intracellularis. In this study, a real-time loop-mediated isothermal amplification (LAMP) assay was developed to detect L. intracellularis based on the conserved region of the 16S ribosomal RNA gene. The optimal reaction conditions of the real-time LAMP was 65 °C for 60 min. The LAMP products could be detected by both real-time turbidity and direct visual inspection...
June 13, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29908204/lipase-mediated-direct-in-situ-ring-opening-polymerization-of-%C3%AE%C2%B5-caprolactone-formed-by-a-chemo-enzymatic-method
#8
Yuanyuan Zhang, Peiyu Lu, Qinghua Sun, Tao Li, Lanjie Zhao, Xin Gao, Fanye Wang, Junhong Liu
A novel method to synthesize poly(ε-caprolactone) (PCL) through a three-step, lipase-mediated chemo-enzymatic reaction from cyclohexanone using an immobilized lipase from Trichosporon laibacchii (T. laibacchii) CBS5791 was developed. The immobilized preparation with 1280 U· g-1 used here was obtained by a method of purification and in situ immobilization where the crude intracellular lipase (cell homogenate) was subjected to partial purification by an aqueous two-phase system (ATPS) consisting of 12% (w/w) polyethylene glycol (PEG) 4000 and 13% (w/w) potassium phosphate (K2 HPO4 ) and then in situ immobilization directly on diatomite from the top PEG-rich phase of ATPS...
June 13, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29908171/screening-of-natural-wolbachia-infection-in-aedes-aegypti-aedes-taeniorhynchus-and-culex-quinquefasciatus-from-guadeloupe-french-west-indies
#9
D Goindin, A Cannet, C Delannay, C Ramdini, J Gustave, C Atyame, A Vega-Rúa
Guadeloupe islands are threatened by several mosquito-borne viruses such as Dengue, Chikungunya, Zika and West Nile virus. It appears essential to look for alternative mosquito control methods such as the incompatible insect technique (ITT) aiming at sterilizing wild females by inundative releases of incompatible males. Before considering the implementation of such a strategy, the characterization of genetic diversity of the endocellular bacterium Wolbachia regarding the local mosquito populations is a critical issue...
June 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29908066/validity-of-hip-worn-inertial-measurement-unit-compared-to-jump-mat-for-jump-height-measurement-in-adolescents
#10
T Rantalainen, K D Hesketh, C Rodda, R L Duckham
Jump tests assess lower body power production capacity, and can be used to evaluate athletic ability and development during growth. Wearable inertial measurement units (IMU) seem to offer a feasible alternative to laboratory-based equipment for jump height assessments. Concurrent validity of these devices for jump height assessments has only been established in adults. Therefore, the purpose of this study was to evaluate the concurrent validity of IMU-based jump height estimate compared to contact mat-based jump height estimate in adolescents...
June 16, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29907892/a-robust-reduced-rank-graph-regression-method-for-neuroimaging-genetic-analysis
#11
Xiaofeng Zhu, Weihong Zhang, Yong Fan
To characterize associations between genetic and neuroimaging data, a variety of analytic methods have been proposed in neuroimaging genetic studies. These methods have achieved promising performance by taking into account inherent correlation in either the neuroimaging data or the genetic data alone. In this study, we propose a novel robust reduced rank graph regression based method in a linear regression framework by considering correlations inherent in neuroimaging data and genetic data jointly. Particularly, we model the association analysis problem in a reduced rank regression framework with the genetic data as a feature matrix and the neuroimaging data as a response matrix by jointly considering correlations among the neuroimaging data as well as correlations between the genetic data and the neuroimaging data...
June 15, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29907807/availability-of-hla-allele-matched-unrelated-donors-estimation-from-haplotype-frequency-in-the-japanese-population
#12
Satoshi Nishiwaki, Hidenori Tanaka, Hiroto Kojima, Shinichiro Okamoto
A human leukocyte antigen (HLA)-matched unrelated donor is the primary alternative donor for allogeneic hematopoietic cell transplantation in Japan. In considering an optimal donor registry size, the availability of HLA-matched donors is important. In this study, the probability of finding an HLA-A, -B, -C, and -DRB1 allele-matched donor was estimated using two different methods based on the haplotype frequencies in the Japanese population: an actual measurement method (AMM) and a formula method (FM). According to AMM, the probabilities of finding an HLA-matched donor were 40...
June 15, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29907742/nmda-antagonists-for-treating-the-non-motor-symptoms-in-parkinson-s-disease
#13
REVIEW
Brigitte Vanle, William Olcott, Jaime Jimenez, Luma Bashmi, Itai Danovitch, Waguih William IsHak
Among patients with Parkinson's disease (PD), depression is prevalent and disabling, impacting both health outcomes and quality of life. There is a critical need for alternative pharmacological methods to treat PD depression, as mainstream antidepressant drugs are largely ineffective in this population. Currently, there are no recommendations for the optimal treatment of PD neuropsychiatric symptoms. Given the dual antidepressant and anti-dyskinetic effects of ketamine and other N-methyl-D-aspartate (NMDA) antagonists for PD, this review aims to examine the current evidence of NMDA antagonists for treating neuropsychiatric symptoms, including memantine, amantadine, ketamine, dizoclopine, and d-cycloserine...
June 15, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29907186/isolation-of-naturally-infecting-leishmania-infantum-from-canine-samples-in-novy-macneal-nicolle-medium-prepared-with-defibrinated-blood-from-different-animal-species
#14
Roseclea Chagas Dos Santos, Flaviane Alves de Pinho, Gabriela Porfírio Passos, Daniela Farias Larangeira, Stella Maria Barrouin-Melo
The most commonly used culture medium for the in vitro isolation of Leishmania spp. from canine biological samples is biphasic Novy-MacNeal-Nicolle (NNN) medium, whose solid phase is prepared using rabbit blood. Leishmania infantum parasites from natural infections are highly sensitive and demanding for growth in axenic conditions when firstly obtained from the dog's body. The objective of this study was to evaluate whether NNN medium (NNN-test) prepared with chicken blood (NNN-C), ox blood (NNN-O), horse blood (NNN-H) or sheep blood (NNN-S) was viable for the isolation of parasites from naturally infected dogs, in an endemic area for visceral leishmaniasis caused by L...
June 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29906924/exploring-the-diluted-ferromagnetic-p-spin-model-with-a-cavity-master-equation
#15
Erik Aurell, Eduardo Domínguez, David Machado, Roberto Mulet
We introduce an alternative solution to Glauber multispin dynamics on random graphs. The solution is based on the recently introduced cavity master equation (CME), a time-closure turning the, in principle, exact dynamic cavity method into a practical method of analysis and of fast simulation. Running CME once is of comparable computational complexity as one Monte Carlo run on the same problem. We show that CME correctly models the ferromagnetic p-spin Glauber dynamics from high temperatures down to and below the spinoidal transition...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906901/investigation-of-voronoi-diagram-based-direction-choices-using-uni-and-bi-directional-trajectory-data
#16
Yao Xiao, Mohcine Chraibi, Yunchao Qu, Antoine Tordeux, Ziyou Gao
In a crowd, individuals make different motion choices such as "moving to destination," "following another pedestrian," and "making a detour." For the sake of convenience, the three direction choices are respectively called destination direction, following direction, and detour direction in this paper. Here, it is found that the featured direction choices could be inspired by the shape characteristics of the Voronoi diagram. To be specific, in the Voronoi cell of a pedestrian, the direction to a Voronoi node is regarded as a potential "detour" direction and the direction perpendicular to a Voronoi link is regarded as a potential "following" direction...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906895/energy-dissipation-of-rigid-dipoles-in-a-viscous-fluid-under-the-action-of-a-time-periodic-field-the-influence-of-thermal-bath-and-dipole-interaction
#17
T V Lyutyy, V V Reva
Ferrofluid heating by an external alternating field is studied based on the rigid dipole model, where the magnetization of each particle in a fluid is supposed to be firmly fixed in the crystal lattice. Equations of motion, employing Newton's second law for rotational motion, the condition of rigid body rotation, and the assumption that the friction torque is proportional to angular velocity are used. This oversimplification permits us to expand the model easily: to take into account the thermal noise and interparticle interaction that allows us to estimate from unified positions the role of thermal activation and dipole interaction in the heating process...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906686/lipidated-%C3%AE-%C3%AE-aa-heterogeneous-peptides-as-antimicrobial-agents
#18
Sylvia Singh, Alekhya Nimmagadda, Ma Su, Minghui Wang, Peng Teng, Jianfeng Cai
With an increase of resistance in bacteria there is an urgent need for alternative treatment methods that could complement conventional antibiotics. In the past two decades, focus has been drawn to Host Defense Peptides (HDPs) as potential antibiotic agents. Herein we reported our studies on the development of lipidated α/α-AA heterogeneous peptides as a new class of HDP mimetics. These compounds showed potent antimicrobial activity toward both Gram-positive and Gram-negative bacteria, and they also displayed excellent selectivity as they only exhibited limited hemolytic activity...
June 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29906567/assessment-of-posaconazole-salvage-therapy-in-chronic-pulmonary-aspergillosis-by-using-predefined-response-criteria
#19
Isabel Rodriguez-Goncer, Chris Harris, Chris Kosmidis, Eavan G Muldoon, Pippa J Newton, David W Denning
OBJECTIVE: Chronic pulmonary aspergillosis (CPA) is a progressive infection that destroys lung tissue in non-immunocompromised patients. First line therapies for CPA (itraconazole and/or voriconazole) are often curtailed due to toxicity or the development of drug resistance. Posaconazole is a potential alternative for these patients. METHODS: Use of posaconazole was funded by the NHS Highly Specialised National Commissioners on an individual basis for patients who failed or did not tolerate first line therapy; those who met predefined criteria for improvement at 4 and 6 months (weight gain and/or improvement in St George's Respiratory Questionnaire) continued posaconazole long-term...
June 12, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29906554/flim-reveals-alternative-ev-mediated-cellular-up-take-pathways-of-paclitaxel
#20
REVIEW
H Saari, E Lisitsyna, K Rautaniemi, T Rojalin, L Niemi, O Nivaro, T Laaksonen, M Yliperttula, E Vuorimaa-Laukkanen
In response to physiological and artificial stimuli, cells generate nano-scale extracellular vesicles (EVs) by encapsulating biomolecules in plasma membrane-derived phospholipid envelopes. These vesicles are released to bodily fluids, hence acting as powerful endogenous mediators in intercellular signaling. EVs provide a compelling alternative for biomarker discovery and targeted drug delivery, but their kinetics and dynamics while interacting with living cells are poorly understood. Here we introduce a novel method, fluorescence lifetime imaging microscopy (FLIM) to investigate these interaction attributes...
June 12, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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