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cyanoglycoside non cyanogenic

Pablo Antonio Maia de Farias, Fernando Gomes Figueredo, Aline Maria Brito Lucas, Rafael Barbosa de Moura, Henrique Douglas Melo Coutinho, Tania Maria Sarmento da Silva, Ana Luiza de Aguiar Rocha Martin, Marta Maria de Fran├ža Fonteles
BACKGROUND: The search for new active compounds from the Brazilian flora has intensified in recent years, especially for new drugs with antibiotic potential. Accordingly, the aim of this study was to determine whether riachin has antibiotic activity in itself or is able to modulate the activity of conventional antibiotics. METHODS: A non-cyanogenic cyanoglycoside known as riachin was isolated from Bauhinia pentandra, and was tested alone and in combination with three antibiotics (clindamycin, amikacin, and gentamicin) against multiresistant bacterial strains (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus)...
2015: Drug Design, Development and Therapy
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