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https://www.readbyqxmd.com/read/27741104/optical-coherence-angiography-a-review
#1
Adam Wylęgała, Sławomir Teper, Dariusz Dobrowolski, Edward Wylęgała
BACKGROUND: Retinal vascular diseases are one of the most common causes of blindness in the developed world. Optical Coherence Tomography Angiography (OCT-A) is a new noninvasive method that uses several algorithms to detect blood movement. This enables the creation of high-resolution vascular images with contrast depicting motionless tissue. METHODS: This review presents the results of articles relevant to age-related macular degeneration (AMD), diabetic retinopathy (DR), and OCT-A...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27596098/systemic-confounders-affecting-serum-measurements-of-omega-3-and-6-polyunsaturated-fatty-acids-in-patients-with-retinal-disease
#2
Anima D Bühler, Felicitas Bucher, Michael Augustynik, Jan Wöhrl, Gottfried Martin, Günther Schlunck, Hansjürgen Agostini, Daniel Böhringer, Gerhard Pütz, Andreas Stahl
BACKGROUND: Omega-3 polyunsaturated fatty acids (PUFAs) have a highly anti-angiogenic effect in animal models. However, the clinical relevance of omega-3PUFAs in human retinal pathologies remains unclear. The ARED 2 study found no effect of omega-3 PUFA supplementation on progression of age related macular degeneration (AMD). The aim of this study was to compare serum levels of omega-3- and omega-6 PUFAs between patients with diabetic retinopathy (DR), AMD and retinal vein occlusion (RVO), and to identify potential confounders of serum level measurements...
2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27459244/quantification-of-the-vascular-endothelial-growth-factor-with-a-bioluminescence-resonance-energy-transfer-bret-based-single-molecule-biosensor
#3
T Wimmer, B Lorenz, K Stieger
Neovascular pathologies in the eye like age-related macular degeneration (AMD), the diabetic retinopathie (DR), retinopathie of prematurity (ROP) or the retinal vein occlusion (RVO) are caused through a hypoxia induced upregulation of the vascular endothelial growth factor (VEGF). So far a correlation of intraocular VEGF concentrations to the impact of the pathologies is limited because of invasive sampling. Therefore, a minimally invasive, repeatable quantification of VEGF levels in the eye is needed to correlate the stage of VEGF induced pathologies as well as the efficacy of anti-VEGF treatment...
December 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/24586308/temsirolimus-inhibits-proliferation-and-migration-in-retinal-pigment-epithelial-and-endothelial-cells-via-mtor-inhibition-and-decreases-vegf-and-pdgf-expression
#4
Raffael Liegl, Susanna Koenig, Jakob Siedlecki, Christos Haritoglou, Anselm Kampik, Marcus Kernt
Due to their high prevalence, retinal vascular diseases including age related macular degeneration (AMD), retinal vein occlusions (RVO), diabetic retinopathy (DR) and diabetic macular edema have been major therapeutic targets over the last years. The pathogenesis of these diseases is complex and yet not fully understood. However, increased proliferation, migration and angiogenesis are characteristic cellular features in almost every retinal vascular disease. The introduction of vascular endothelial growth factor (VEGF) binding intravitreal treatment strategies has led to great advances in the therapy of these diseases...
2014: PloS One
https://www.readbyqxmd.com/read/22675660/antiangiogenic-therapy-for-ischemic-retinopathies
#5
Motasem Al-Latayfeh, Paolo S Silva, Jennifer K Sun, Lloyd Paul Aiello
Neovascularization is a common pathological process in various retinal vascular disorders including diabetic retinopathy (DR), age-related macular degeneration (AMD) and retinal vein occlusion (RVO). The development of neovascular vessels may lead to complications such as vitreous hemorrhage, fibrovascular tissue formation, and traction retinal detachments. Ultimately, irreversible vision loss may result. Various proangiogenic factors are involved in these complex processes. Different antiangiogenic drugs have been formulated in an attempt treat these vascular disorders...
June 2012: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/19965832/correlation-between-fluorescein-angiography-and-spectral-domain-optical-coherence-tomography-in-the-diagnosis-of-cystoid-macular-edema
#6
MULTICENTER STUDY
T Jittpoonkuson, P M T Garcia, R B Rosen
AIMS: To compare the ability to detect cystoid macular edema (CME) and its late complications between spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA). METHODS: Retrospective, observational, case series. 85 Eyes who had FA and SD-OCT performed on the same day at first visit and/or at follow-up visits were included. FA and SD-OCT images were evaluated for the evidences associated with CME and other structural changes of macula...
September 2010: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/19925410/current-molecular-understanding-and-future-treatment-strategies-for-pathologic-ocular-neovascularization
#7
REVIEW
Michael J Tolentino
The leading cause of blindness in the developed world results from several disorders that have pathologic ocular neovascularization as the common pathway leading to vision loss. These disorders include exudative age related macular degeneration (AMD), diabetic retinopathy (DR), retinopathy of prematurity (ROP), retinal vein occlusions (RVO) and ocular tumors. Because neovascularization is the common pathway to blindness in these highly prevalent conditions, the recent understanding of the cascade of angiogenesis has led to clinically available molecular therapeutics that have been proven to restore and preserve vision in patients that suffer from these blinding conditions...
November 2009: Current Molecular Medicine
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