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https://www.readbyqxmd.com/read/29691993/epidemiology-and-molecular-characterization-of-chicken-anaemia-virus-from-commercial-and-native-chickens-in-taiwan
#1
S-C Ou, H-L Lin, P-C Liu, H-J Huang, M-S Lee, Y-Y Lien, Y-L Tsai
Chicken infectious anaemia (CIA) is a disease with a highly economic impact in the poultry industry. The infected chickens are characterized by aplastic anaemia and extreme immunosuppression, followed by the increased susceptibility to secondary infectious pathogens and suboptimal immune responses for vaccination. Commercially available CIA vaccines are routinely used in the breeders in Taiwan to protect their progeny with maternal-derived antibodies. However, CIA cases still occur in the field and little is known about the genetic characteristics of Taiwanese chicken anaemia viruses (CAVs)...
April 25, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29691990/altered-functional-connectivity-strength-and-its-correlations-with-cognitive-function-in-subjects-with-ultra-high-risk-for-psychosis-at-rest
#2
Ran-Ran Li, Hai-Long Lyu, Feng Liu, Nan Lian, Ren-Rong Wu, Jing-Ping Zhao, Wen-Bin Guo
AIMS: Evidence of altered structural and functional connectivity in the frontal-occipital network is associated with cognitive deficits in patients with schizophrenia. However, the altered patterns of functional connectivity strength (FCS) in individuals with ultra-high risk (UHR) for psychosis remain unknown. In this study, whole-brain FCS was assessed to examine the altered patterns of FCS in UHR subjects. METHODS: A total of 34 UHR subjects and 37 age- and sex-matched healthy controls were enrolled to undergo resting-state functional magnetic resonance imaging...
April 24, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29691634/the-ctenidium-of-the-giant-clam-tridacna-squamosa-expresses-an-ammonium-transporter-1-that-displays-light-suppressed-gene-and-protein-expression-and-may-be-involved-in-ammonia-excretion
#3
Mel V Boo, Kum C Hiong, Enan J K Goh, Celine Y L Choo, Wai P Wong, Shit F Chew, Yuen K Ip
Ammonium transporters (AMTs) can participate in ammonia uptake or excretion across the plasma membrane of prokaryotic, plant and invertebrate cells. The giant clam, Tridacna squamosa, harbors nitrogen-deficient symbiotic zooxanthellae, and normally conducts light-enhanced ammonia absorption to benefit the symbionts. Nonetheless, it can excrete ammonia when there is a supply of exogenous nitrogen or exposed to continuous darkness. This study aimed to elucidate the role of AMT1 in the ctenidium of T. squamosa by cloning and characterizing the AMT1/AMT1, determining its subcellular localization, and examining changes in its transcript and protein expression levels in response to light exposure...
April 24, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/29691633/emdunifrac-exact-linear-time-computation-of-the-unifrac-metric-and-identification-of-differentially-abundant-organisms
#4
Jason McClelland, David Koslicki
Both the weighted and unweighted UniFrac distances have been very successfully employed to assess if two communities differ, but do not give any information about how two communities differ. We take advantage of recent observations that the UniFrac metric is equivalent to the so-called earth mover's distance (also known as the Kantorovich-Rubinstein metric) to develop an algorithm that not only computes the UniFrac distance in linear time and space, but also simultaneously finds which operational taxonomic units are responsible for the observed differences between samples...
April 25, 2018: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29691483/a-traditional-evolutionary-history-of-foot-and-mouth-disease-viruses-in-southeast-asia-challenged-by-analyses-of-non-structural-protein-coding-sequences
#5
Barbara Brito, Steven J Pauszek, Ethan J Hartwig, George R Smoliga, Le T Vu, Pham V Dong, Carolina Stenfeldt, Luis L Rodriguez, Donald P King, Nick J Knowles, Katarzyna Bachanek-Bankowska, Ngo T Long, Do H Dung, Jonathan Arzt
Recombination of rapidly evolving RNA-viruses provides an important mechanism for diversification, spread, and emergence of new variants with enhanced fitness. Foot-and-mouth disease virus (FMDV) causes an important transboundary disease of livestock that is endemic to most countries in Asia and Africa. Maintenance and spread of FMDV are driven by periods of dominance of specific viral lineages. Current understanding of the molecular epidemiology of FMDV lineages is generally based on the phylogenetic relationship of the capsid-encoding genes, with less attention to the process of recombination and evolution of non-structural proteins...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691442/publisher-correction-mir-3140-suppresses-tumor-cell-growth-by-targeting-brd4-via-its-coding-sequence-and-downregulates-the-brd4-nut-fusion-oncoprotein
#6
Erina Tonouchi, Yasuyuki Gen, Tomoki Muramatsu, Hidekazu Hiramoto, Kousuke Tanimoto, Jun Inoue, Johji Inazawa
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29691411/analysis-of-predicted-loss-of-function-variants-in-uk-biobank-identifies-variants-protective-for-disease
#7
Connor A Emdin, Amit V Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M Zekavat, Akihiro Nomura, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Daniel Chasman, Paul Ridker, Joshua Denny, Lisa Bastarache, Judith H Lichtman, Gail D'Onofrio, Jennifer Mattera, John A Spertus, Wayne H-H Sheu, Kent D Taylor, Bruce M Psaty, Stephen S Rich, Wendy Post, Jerome I Rotter, Yii-Der Ida Chen, Harlan Krumholz, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Less than 3% of protein-coding genetic variants are predicted to result in loss of protein function through the introduction of a stop codon, frameshift, or the disruption of an essential splice site; however, such predicted loss-of-function (pLOF) variants provide insight into effector transcript and direction of biological effect. In >400,000 UK Biobank participants, we conduct association analyses of 3759 pLOF variants with six metabolic traits, six cardiometabolic diseases, and twelve additional diseases...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691383/the-gastrodia-elata-genome-provides-insights-into-plant-adaptation-to-heterotrophy
#8
Yuan Yuan, Xiaohua Jin, Juan Liu, Xing Zhao, Junhui Zhou, Xin Wang, Deyi Wang, Changjiangsheng Lai, Wei Xu, Jingwen Huang, Liangping Zha, Dahui Liu, Xiao Ma, Li Wang, Menyan Zhou, Zhi Jiang, Hubiao Meng, Huasheng Peng, Yuting Liang, Ruiqiang Li, Chao Jiang, Yuyang Zhao, Tiegui Nan, Yan Jin, Zhilai Zhan, Jian Yang, Wenkai Jiang, Luqi Huang
We present the 1.06 Gb sequenced genome of Gastrodia elata, an obligate mycoheterotrophic plant, which contains 18,969 protein-coding genes. Many genes conserved in other plant species have been deleted from the G. elata genome, including most of those for photosynthesis. Additional evidence of the influence of genome plasticity in the adaptation of this mycoheterotrophic lifestyle is evident in the large number of gene families that are expanded in G. elata, including glycoside hydrolases and urease that likely facilitate the digestion of hyphae are expanded, as are genes associated with strigolactone signaling, and ATPases that may contribute to the atypical energy metabolism...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691332/clinically-relevant-plasmid-host-interactions-indicate-that-transcriptional-and-not-genomic-modifications-ameliorate-fitness-costs-of-klebsiella-pneumoniae-carbapenemase-carrying-plasmids
#9
Michelle M C Buckner, Howard T H Saw, Rachael N Osagie, Alan McNally, Vito Ricci, Matthew E Wand, Neil Woodford, Alasdair Ivens, Mark A Webber, Laura J V Piddock
The rapid dissemination of antimicrobial resistance (AMR) around the globe is largely due to mobile genetic elements, such as plasmids. They confer resistance to critically important drugs, including extended-spectrum beta-lactams, carbapenems, and colistin. Large, complex resistance plasmids have evolved alongside their host bacteria. However, much of the research on plasmid-host evolution has focused on small, simple laboratory plasmids in laboratory-adapted bacterial hosts. These and other studies have documented mutations in both host and plasmid genes which occur after plasmid introduction to ameliorate fitness costs of plasmid carriage...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29691311/software-for-convenient-correction-of-artifacts-in-sonomicrometry
#10
Alexander W Chen, Walter Herzog
Sonomicrometry is widely applied in biomechanics and physiology to measure precise distances with high temporal resolution. Although commonly used, its usefulness is often limited by the presence of artifacts that require correction. Unfortunately, procedures reported in the literature for artifact correction are often unclear. Furthermore, currently available tools for artifact correction require significant manual manipulations, the consistency of which takes painstaking effort to verify. To improve the efficiency and consistency of sonomicrometry, we have developed a new software tool for the correction of sonomicrometry artifacts...
April 24, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29691280/a-transcriptional-regulatory-network-containing-nuclear-receptors-and-lncrnas-controls-basal-and-drug-induced-expression-of-cytochrome-p450s-in-heparg-cells
#11
Liming Chen, Yifan Bao, Stephanie C Piekos, Kexin Zhu, Lirong Zhang, Xiao-Bo Zhong
Cytochrome P450 enzymes are responsible for metabolizing drugs. Expression of P450s can directly affect drug metabolism, resulting in various outcomes in therapeutic efficacy and adverse effects. Several nuclear receptors are transcription factors that can regulate expression of P450s at both basal and drug-induced levels. Some long non-coding RNAs (lncRNAs) near a transcription factor are found to participate in the regulatory functions of the transcription factors. The aim of this study is to determine whether there is a transcriptional regulatory network containing nuclear receptors and lncRNAs controlling both basal and drug-induced expression of P450s in HepaRG cells...
April 24, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29691205/developing-sustainable-and-impactful-mobile-phone-hiv-testing-interventions-for-spanish-speaking-men-who-have-sex-with-men-in-the-united-states-lessons-learned-from-informative-interviews
#12
Jason Mitchell, Maria Beatriz Torres, Lucy Asmar, Thu Danh, Keith J Horvath
BACKGROUND: Although many men who have sex with men (MSM) test for HIV at least once in their lifetime, opportunities to improve regular HIV testing, particularly among Hispanic or Latino MSM, is needed. Many mHealth interventions in development, including the ones on HIV testing, have primarily focused on English-speaking white, black, and MSM of other races. To date, no studies have assessed app use, attitudes, and motivations for downloading and sustaining use of mobile apps and preferences with respect to HIV prevention among Spanish-speaking, Hispanic MSM in the United States...
April 24, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29691204/perceptions-about-disseminating-health-information-among-mommy-bloggers-quantitative-study
#13
Amelia Burke-Garcia, Gary L Kreps, Kevin B Wright
BACKGROUND: Social media are potentially powerful channels for communicating relevant health information in culturally sensitive and influential ways to key audiences. Moreover, these channels hold promise for promoting awareness and knowledge of health risks, prevention, and treatment by utilizing opinion leaders for message dissemination. Despite limited empirical evidence to-date, early promising results suggest that blogs are a form of social media that should be examined as worthy channels for health communication...
April 24, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29691178/a-higher-altitude-is-an-independent-risk-factor-for-venous-thromboembolisms-after-total-hip-arthroplasty
#14
Dhanur Damodar, Chester J Donnally, Jonathan I Sheu, Tsun Y Law, Martin W Roche, Victor H Hernandez
BACKGROUND: High altitudes lead to physiological changes that may predispose to venous thromboembolisms (VTEs) including deep vein thrombosis and pulmonary embolism (PE). No prior study has evaluated if there is also a higher risk of VTEs for total hip arthroplasties (THAs) performed at higher elevations. The purpose of this retrospective study was to identify if undergoing THA at a higher altitude center (>4000 feet above sea level) is an independent risk factor for a postoperative VTE...
March 27, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29691096/prevalence-of-lung-cancer-in-isfahan-province-iran
#15
Zahra Tolou Ghamari
OBJECTIVE: To describe for the first time period prevalence (PP) and incidence rate (Ir) for patients with lung cancer in Isfahan Province/Iran. DESIGN: Data associated to the Surveillance, Epidemiology, and End Results; (SEER) was collected from the Isfahan Cancer Registry from March 2011 to March 2015. Lung cancer was distinguished by the related established topography code. PP and Ir were calculated and expressed per 100,000 persons. RESULTS: In all, 548 females and 1399 males were identified...
April 21, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29691042/foot-fractures-in-polytrauma-patients-injury-characteristics-and-timing-of-diagnosis
#16
Quirine M J van der Vliet, Robert C Lucas, George Velmahos, Roderick M Houwert, Luke P H Leenen, Falco Hietbrink, Marilyn Heng
BACKGROUND: Due to prioritizing care and concomitant injuries, foot fractures in polytrauma patients often receive limited attention initially. However, as foot function is important, treatment and diagnosis of these fractures should be accurate. The aims of this study were to assess the incidence and distribution of foot fractures in polytrauma patients and to examine possible risk factors for delayed diagnosis of foot fractures. METHODS: This was a retrospective study on all adult (≥18 years) polytrauma (ISS ≥16) patients admitted to a single level 1 trauma center between 2006 and 2016...
April 17, 2018: Injury
https://www.readbyqxmd.com/read/29690984/-disease-burden-and-definition-of-sepsis-in-adults
#17
Anders Perner, Annmarie Touborg Lassen, Jens Schierbeck, Merete Storgaard, Nanna Reiter, Thomas Benfield
Sepsis is the terminal event for most infectious diseases and is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is frequent, deathly and associated with high burden for patients, relatives and societies. Sepsis is underreported in diagnostic coding, making estimation difficult of the true burden of the disease in Denmark. It is likely, however, that sepsis contributes to 15% of all deaths in Denmark.
April 9, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29690875/cross-species-inference-of-long-non-coding-rnas-greatly-expands-the-ruminant-transcriptome
#18
Stephen J Bush, Charity Muriuki, Mary E B McCulloch, Iseabail L Farquhar, Emily L Clark, David A Hume
BACKGROUND: mRNA-like long non-coding RNAs (lncRNAs) are a significant component of mammalian transcriptomes, although most are expressed only at low levels, with high tissue-specificity and/or at specific developmental stages. Thus, in many cases lncRNA detection by RNA-sequencing (RNA-seq) is compromised by stochastic sampling. To account for this and create a catalogue of ruminant lncRNAs, we compared de novo assembled lncRNAs derived from large RNA-seq datasets in transcriptional atlas projects for sheep and goats with previous lncRNAs assembled in cattle and human...
April 24, 2018: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/29690801/a-link-between-expression-level-of-long-non-coding-rna-zfas1-in-breast-tissue-of-healthy-women-and-obesity
#19
Yaser Mansoori, Mohammad Bagher Tabei, Alireza Askari, Pantea Izadi, Abdolreza Daraei, Mohammad Mehdi Naghizadeh, Zahra Zendehbad, Milad Bastami, Ziba Nariman-Saleh-Fam, Hosein Mansoori, Javad Tavakkoly-Bazzaz
BACKGROUND: Epidemiological and experimental literature indicates that the risk of breast cancer incidence is strongly linked to hormone-dependent factors, including reproductive history and obesity. However, the molecular mechanisms underlying the association between these factors and breast cancer risk are poorly understood. The aim of this study, therefore, was to determine whether obesity and reproductive history are associated with expression levels of two breast cancer-related long non-coding RNAs (lncRNAs), namely ZFAS1 and SRA1 in cancer-free breast tissues of women...
April 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29690788/reconciling-hospital-acquired-complications-and-chadx-in-victorian-coded-hospital-data
#20
Jennie Shepheard, Elsa Lapiz, Carla Read, Terri J Jackson
BACKGROUND: The Council of Australian Governments has focused the attention of health service managers and state health departments on a list of hospital-acquired complications (HACs) proposed as the basis of funding adjustments for poor quality of hospital inpatient care. These were devised for the Australian Commission on Safety and Quality in Health Care as a subset of their earlier classification of hospital-acquired complications (CHADx) and designed to be used by health services to monitor safety performance for their admitted patients...
January 1, 2018: Health Information Management: Journal of the Health Information Management Association of Australia
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