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Enfermedades infecciosas

Santiago Moreno, Antonio Antela, Felipe García, Julia Del Amo, Vicente Boix, Pep Coll, Claudia Fortuny, Juan L Gómez Sirvent, Félix Gutiérrez, José A Iribarren, Josep M Llibre, Juan C López Bernaldo de Quirós, Juan Emilio Losa, Ana Lozano, Michael Meulbroek, Julián Olalla, Ferran Pujol, Federico Pulido, Manuel Crespo Casal, Juan González García, José López Aldeguer, Jose A Pérez Molina, Daniel Podzamczer Palter, Antonio Rivero Román
Administration of antiretroviral drugs to individuals exposed to, but not infected by, HIV has been shown to reduce the risk of transmission. The efficacy of pre-exposure prophylaxis (PrEP) makes it obligatory to include it in an integral program of prevention of HIV transmission, together with other measures, such as use of the condom, training, counseling, and appropriate treatment of infected individuals. In this document, the AIDS Study Group (GeSIDA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica [SEIMC]) provides its views on this important subject...
February 21, 2017: Enfermedades Infecciosas y Microbiología Clínica
Javier Ariza, Javier Cobo, Josu Baraia-Etxaburu, Natividad Benito, Guillermo Bori, Javier Cabo, Pablo Corona, Jaime Esteban, Juan Pablo Horcajada, Jaime Lora-Tamayo, Oscar Murillo, Julián Palomino, Jorge Parra, Carlos Pigrau, José Luis Del Pozo, Melchor Riera, Dolores Rodríguez, Mar Sánchez-Somolinos, Alex Soriano, M Dolores Del Toro, Basilio de la Torre
The incidence of prosthetic joint infection (PJI) is expected to increase in the coming years. PJI has serious consequences for patients, and high costs for the health system. The complexity of these infections makes it necessary to organize the vast quantity of information published in the last several years. The indications for the choice of a given surgical strategy and the corresponding antimicrobial therapy are specifically reviewed. The authors selected clinically relevant questions and then reviewed the available literature in order to give recommendations according to a pre-determined level of scientific evidence...
March 2017: Enfermedades Infecciosas y Microbiología Clínica
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Enfermedades Infecciosas y Microbiología Clínica
J A Pineda, L E Morano-Amado, R Granados, J Macías, F Téllez, M García-Deltoro, M J Ríos, A Collado, M Delgado-Fernández, M Suárez-Santamaría, M Serrano, C Miralles-Álvarez, K Neukam
OBJECTIVE: The aim of this study was to determine the predictive capacity of response at treatment week (TW) 4 for the achievement of sustained virological response 12 weeks after the scheduled end of therapy date (SVR12) to treatment against hepatitis C virus (HCV) genotype 3 (GT3) infection with all-oral direct-acting antiviral (DAA) -based regimens. PATIENTS AND METHODS: From a prospective multicohort study, HCV GT3-infected patients who completed a course of currently recommended DAA-based therapy at 33 Spanish hospitals and who had reached the SVR12 evaluation time-point were selected...
January 28, 2017: Clinical Microbiology and Infection
K Neukam, L E Morano-Amado, A Rivero-Juárez, J Macías, R Granados, A Romero-Palacios, M Márquez, D Merino, E Ortega, J C Alados-Arboledas, J Cucurull, M Omar, P Ryan-Murua, J A Pineda
The purpose of this investigation was to evaluate the impact of liver stiffness (LS) on the response to direct-acting antiviral (DAA)-based therapy against hepatitis C virus (HCV) infection in cirrhotic patients. Those patients included in two Spanish prospective cohorts of patients receiving therapy based on at least one DAA, who showed a baseline LS ≥ 12.5 kPa and who had reached the scheduled time point for sustained virological response evaluation 12 weeks after completing therapy (SVR12) were analysed...
December 21, 2016: European Journal of Clinical Microbiology & Infectious Diseases
Claudio Hernández Mosqueira, Dagoberto Hernández Vasquez, Alexis Caniuqueo Vargas, Humberto Castillo Quezada, Sandro Fernandes Da Silva, Gustavo Pavez-Adasme, Cristian Martínez Salazar, Jaime Cárcamo-Oyarzún, José Fernandes Filho
Introducción: Chile en las últimas décadas ha experimentado un cambio en su perfil epidemiológico nutricional, pasando de una situación caracterizada por una elevada prevalencia de desnutrición y enfermedades infecciosas/parasitarias a otro completamente distinto, en donde las enfermedades crónicas y degenerativas presentan una elevada prevalencia.Objetivo: el objetivo del estudio es elaborar tablas de referencia de aspectos antropométricos y de condición física en estudiantes varones de 10 a 14 años de la ciudad de Chillán...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Nicolás Merchante, Antonio Rivero-Juárez, Francisco Téllez, Dolores Merino, Maria José Ríos-Villegas, Guillermo Ojeda-Burgos, Mohamed Omar, Juan Macías, Antonio Rivero, Monserrat Pérez-Pérez, Miguel Raffo, Inmaculada López-Montesinos, Manuel Márquez-Solero, Maria Amparo Gómez-Vidal, Juan A Pineda
BACKGROUND: A liver stiffness below 21 kPa has a high negative predictive value to exclude the presence of esophageal varices at risk of bleeding in HIV/hepatitis C virus (HCV)-coinfected patients. Consequently, upper gastrointestinal endoscopy (UGE) for the screening of esophageal varices could be avoided in these patients. However, this strategy has not been widely accepted due to concerns about its safety. OBJECTIVE: To assess the ability of liver stiffness to predict the risk of portal hypertensive gastrointestinal bleeding (PHGB) in HIV/HCV-coinfected patients with compensated cirrhosis...
February 20, 2017: AIDS
A Rivero-Juarez, L F Lopez-Cortes, M Castaño, D Merino, M Marquez, M Mancebo, F Cuenca-Lopez, P Jimenez-Aguilar, I Lopez-Montesinos, S Lopez-Cardenas, A Collado, M A Lopez-Ruz, M Omar, F Tellez, X Perez-Stachowski, J Hernandez-Quero, J A Girón-Gonzalez, E Fernandez-Fuertes, A Rivero
In April 2015, the Spanish National Health System (SNHS) developed a national strategic plan for the diagnosis, treatment, and management of hepatitis C virus (HCV). Our aim was to analyze the impact of this on human immunodeficiency virus (HIV)-infected patients included in the HERACLES cohort during the first 6 months of its implementation. The HERACLES cohort (NCT02511496) was set up in March 2015 to evaluate the status and follow-up of chronic HCV infection in patients co-infected with HIV in the south of Spain...
March 2017: European Journal of Clinical Microbiology & Infectious Diseases
Miguel Santin, José-María García-García, David Rigau, Neus Altet, Luis Anibarro, Irma Casas, Nuria Díez, Mercedes García-Gasalla, Xavier Martínez-Lacasa, Antón Penas, Elvira Pérez-Escolano, Francisca Sánchez, José Domínguez
Interferon-gamma release assays are widely used for the diagnosis of tuberculosis infection in Spain. However, there is no consensus on their application in specific clinical scenarios. To develop a guide-line for their use, a panel of experts comprising specialists in infectious diseases, respiratory diseases, microbiology, pediatrics and preventive medicine, together with a methodologist, conducted a systematic literature search, summarized the findings, rated the quality of the evidence, and formulated recommendations following the Grading of Recommendations of Assessment Development and Evaluations methodology...
September 2016: Archivos de Bronconeumología
Karin Neukam, José A Mira, Antonio Collado, Antonio Rivero-Juárez, Patricia Monje-Agudo, Josefa Ruiz-Morales, María José Ríos, Dolores Merino, Francisco Téllez, Inés Pérez-Camacho, María Carmen Gálvez-Contreras, Antonio Rivero, Juan A Pineda
OBJECTIVE: To assess the current frequency of ART-associated grade 3-4 transaminase elevations (TE) and grade 4 total bilirubin elevations (TBE) in HIV-infected patients with chronic hepatitis B and/or C, who start a new regimen of ART. PATIENTS AND METHODS: A total of 192 pre-treated or treatment-naive HIV infected patients with HBV and/or HCV-coinfection who started ART in eight Southern Spanish centers from July/2011-December/2013, were followed for 12 months in this prospective study...
2016: PloS One
Nicolás Merchante, Francisco Téllez, Antonio Rivero-Juárez, Maria José Ríos-Villegas, Dolores Merino, Manuel Márquez-Solero, Mohamed Omar, Eva Recio, Montserrat Pérez-Pérez, Ángela Camacho, Sara Macías-Dorado, Juan Macías, Sandra Lorenzo-Moncada, Antonio Rivero, Juan A Pineda
BACKGROUND: Our objective was to assess the predictive value of the changes of liver stiffness (LS) for clinical outcome in HIV/HCV-coinfected patients with compensated liver cirrhosis and a LS value < 40 kPa. METHODS: Prospective cohort of 275 HIV/HCV-coinfected patients with cirrhosis, no previous liver decompensation (LD) and LS < 40 kPa. The time from diagnosis to LD and/or hepatocellular carcinoma (HCC) and the predictors of this outcome were evaluated...
2015: BMC Infectious Diseases
A Rivero-Juarez, A Gutierrez-Valencia, M Castaño, D Merino, K Neukam, M J Ríos-Villegas, M A Lopez-Ruz, P Jiménez-Aguilar, M Marquez, A Collado, A Gomez-Vidal, J Hernandez-Quero, F Tellez, E Fernandez-Fuertes, A Rivero, L F López-Cortés
The implementation of hepatitis C (HCV) direct-acting antiviral drugs is prioritized in several populations in which its application provides the most immediate and impactful benefit. In this scenario, a precise knowledge of the situation of human immunodeficiency virus (HIV)/HCV chronic co-infection is required to adequately address this disease. This cross-sectional study was performed in 21 hospitals in Andalusia (Spain). The study population consisted of HIV-infected patients with an active HCV chronic infection who were not receiving HCV treatment at the time of inclusion...
November 2015: European Journal of Clinical Microbiology & Infectious Diseases
Sergio Alberto Ramirez-Garcia, Luis Javier Flores-Alvarado, Luz Rosalba Topete-González, Claudia Charles-Niño, Manuel Mazariegos-Rubi, Nory Omayra Dávalos-Rodríguez
BACKGROUND: TJP1 gene encodes a ZO-1 protein that is required for the recruitment of occludins and claudins in tight junction, and is involved in cell polarisation. It has different variations, the frequency of which has been studied in different populations. In Mexico there are no studies of this gene. These are required because their polymorphisms can be used in studies associated with medicine and surgery. Therefore, the aim of this study was to estimate the frequency of alleles and genotypes of rs2291166 gene polymorphism TJP1 in Mexico Mestizos population, and to estimate the conformational effect of an amino acid change...
January 2016: Cirugia y Cirujanos
A Rivero-Juarez, A Caruz, L M Real, L Martinez-Dueñas, F J Marquez, M Frias, E Recio, A Gordon, J A Pineda, A Rivero, A Camacho
Hepatitis C virus (HCV) viral persistence in patients with spontaneous viral clearance is controversial. Several studies have shown HCV-RNA in peripheral blood mononuclear cells (PBMCs) and/or liver tissue among patients who have cleared the virus spontaneously, suggesting that viral persistence is a common situation that could involve the entire population studied. Thus, our aim was to evaluate HCV-RNA persistence in PBMCs and hepatocytes in subjects infected with the human immunodeficiency virus (HIV). A total of 1508 patients were prospectively followed and tested for anti-HCV antibodies and HCV-RNA to identify the patients who achieved spontaneous viral clearance...
November 2015: European Journal of Clinical Microbiology & Infectious Diseases
P Monje-Agudo, A Castro-Iglesias, A Rivero-Juárez, F Martínez-Marcos, E Ortega-González, L M Real, B Pernas, N Merchante, P Cid, J Macías, M D Merino, A Rivero, A Mena, K Neukam, J A Pineda
It is commonly accepted that human immunodeficiency (HIV) coinfection negatively impacts on the rates of sustained virological response (SVR) to therapy with pegylated interferon plus ribavirin (PR). However, this hypothesis is derived from comparing different studies. The aim of this study was to determine the impact of HIV coinfection on SVR to PR in one single population. In a multicentric, prospective study conducted between 2000 and 2013, all previously naïve hepatitis C virus (HCV)-infected patients who started PR in five Spanish hospitals were analyzed...
October 2015: European Journal of Clinical Microbiology & Infectious Diseases
J A Mira, K Neukam, L F López-Cortés, A Rivero-Juárez, F Téllez, J A Girón-González, I de los Santos-Gil, G Ojeda-Burgos, D Merino, M J Ríos-Villegas, A Collado, A Torres-Cornejo, J Macías, A Rivero, M Pérez-Pérez, J A Pineda
The aim of this study was to assess the efficacy of and the risk of major bleeding during pegylated interferon (peg-IFN)/ribavirin (RBV) treatment among human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients according to the pretreatment platelet count. Two hundred and seventy-four HCV/HIV-coinfected, previously naïve individuals with compensated cirrhosis enrolled in one Spanish prospective cohort who received peg-IFN/RBV were included in this study. The frequency of severe bleeding and sustained virological response (SVR) rate were compared between patients with a pretreatment platelet count ≤70,000/mm(3) and >70,000/mm(3), respectively...
September 2015: European Journal of Clinical Microbiology & Infectious Diseases
José Manuel Ramos, Gregorio González-Alcaide, Félix Gutiérrez
INTRODUCTION: The bibliometric analysis of production and impact of documents by knowledge area is a quantitative and qualitative indicator of research activity in this field. The aim of this article is to determine the contribution of Spanish research institutions in Infectious Diseases and Microbiology in recent years. MATERIAL AND METHODS: Documents published in the journals included in the categories "Infectious Diseases" and "Microbiology" of the Web of Science (Science Citation Index Expanded) of the ISI Web of Knowledge from the year 2000-2013 were analysed...
March 2016: Enfermedades Infecciosas y Microbiología Clínica
David V McQueen
No abstract text is available yet for this article.
June 2015: Global Health Promotion
José A Pérez-Molina, Federico Pulido
INTRODUCTION: The entry into force of Royal Decree (RD) 16/2012 in Spain in September 2012 led to the exclusion of the group of irregular immigrants from the National Healthcare System. With this work, GESIDA attempts to measure the impact of the entry into force of the RD in relation to its application by the Autonomous Communities (CCAA), and how it has affected the health care of irregular immigrants infected with HIV. METHODS: Information was requested from the 17 CCAA of the existence of measures to ensure the care and treatment of people with HIV infection that were left unprotected because of the implementation of the RD...
August 2015: Enfermedades Infecciosas y Microbiología Clínica
S Alfayate-Miguélez, J Ruiz Gómez, M Sanchez-Solis de Querol, C Guerrero Gómez, M Pérez Simón, M M Ortiz Romero, M L Núñez Trigueros, M L López Yepes, A Blazquez Abellán, J M Zarauz García, G Ruiz Merino, M P Ortuño del Moral
INTRODUCTION AND OBJECTIVES: Streptococcus pneumoniae (SP) is a human pathogen that involves a high use of antibiotics. The objective of the study was to determine the susceptibility to commonly used antibiotics and their associated risk factors, in order to promote rational use of antibiotics. PATIENTS AND METHODS: In A multicentre study was conducted in summer 2009 and winter 2010 on children attending paediatric clinics in the Region of Murcia. A nasopharyngeal sample was collected and an epidemiological questionnaire was completed...
September 2015: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
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