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Enfermedades infecciosas

Fernando Chaves, José Garnacho-Montero, José Luis Del Pozo, Emilio Bouza, José Antonio Capdevila, Marina de Cueto, M Ángeles Domínguez, Jaime Esteban, Nuria Fernández-Hidalgo, Marta Fernández Sampedro, Jesús Fortún, María Guembe, Leonardo Lorente, Jose Ramón Paño, Paula Ramírez, Miguel Salavert, Miguel Sánchez, Jordi Vallés
Catheter-related bloodstream infections (CRBSI) constitute an important cause of hospital-acquired infection associated with morbidity, mortality, and cost. The aim of these guidelines is to provide updated recommendations for the diagnosis and management of CRBSI in adults. Prevention of CRBSI is excluded. Experts in the field were designated by the two participating Societies (Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica and the Sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias)...
February 2018: Enfermedades Infecciosas y Microbiología Clínica
Julio César Padilla, Fredy Eberto Lizarazo, Olga Lucía Murillo, Fernando Antonio Mendigaña, Edwin Pachón, Mauricio Javier Vera
Introducción. Las enfermedades transmitidas por vectores representan más de 17 % de todas las enfermedades infecciosas y causan anualmente un millón de defunciones a nivel mundial. En Colombia, la malaria, el dengue, la enfermedad de Chagas y las leishmaniasis son condiciones endemoepidémicas persistentes.Objetivo. Determinar el comportamiento epidemiológico de las enfermedades transmitidas por vectores en zonas urbanas y rurales de Colombia entre 1990 y 2016.Materiales y métodos. Se hizo un estudio descriptivo del comportamiento epidemiológico de las principales enfermedades transmitidas por vectores en zonas urbanas y rurales de Colombia entre 1990 y 2016, con la información proveniente de fuentes oficiales secundarias...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
Juan I Degiuseppe
INTRODUCTION: Acute diarrhea is one of the most serious public health problems in developing countries because it is generally associated with unfavorable living conditions. The objective of this study was to analyze trends in hospital discharges for intestinal infectious disease in children under age 5 recorded in official public hospitals from Argentina in the 2005-2013 period. POPULATION AND METHODS: This was an ecological, time-series study based on data provided by the Health Statistics and Information Department, at a national and regional level...
August 1, 2017: Archivos Argentinos de Pediatría
Ivana Cristina Vieira de Lima, Maria da Conceição Dos Santos Oliveira Cunha, Gilmara Holanda da Cunha, Marli Teresinha Gimeniz Galvão
OBJECTIVE: To analyze the reproductive aspects and knowledge of family planning among women with Acquired Immunodeficiency Syndrome (AIDS). METHOD: Cross-sectional and descriptive study carried out from January to December, 2015, in the outpatient care of infectious disease unit in a hospital located in Fortaleza, Ceará. Data were collected through a form applied by interview in a private setting. RESULTS: 102 women participated in the study...
May 25, 2017: Revista da Escola de Enfermagem da U S P
Mario Frias, Antonio Rivero-Juarez, Francisco Tellez, Monserrat Perez-Perez, Angela Camacho, Isabel Machuca, Sandra Lorenzo-Moncada, Pedro Lopez-Lopez, Antonio Rivero
OBJECTIVE: To evaluate the rate of spontaneous resolution of chronic hepatitis C (CHC) infection in a cohort of HIV-infected patients. METHODS: A retrospective analysis of 509 HIV-infected patients with chronic HCV infection was performed at two reference hospitals in Andalusia. The main variable of the study was spontaneous clearance of CHC, defined as a negative HCV RNA result after at least two previous quantitative measurements of HCV RNA separated by a minimum of 12 months...
2017: PloS One
Santiago Moreno, Antonio Antela, Felipe García, Julia Del Amo, Vicente Boix, Pep Coll, Claudia Fortuny, Juan L Gómez Sirvent, Félix Gutiérrez, José A Iribarren, Josep M Llibre, Juan C López Bernaldo de Quirós, Juan Emilio Losa, Ana Lozano, Michael Meulbroek, Julián Olalla, Ferran Pujol, Federico Pulido, Manuel Crespo Casal, Juan González García, José López Aldeguer, Jose A Pérez Molina, Daniel Podzamczer Palter, Antonio Rivero Román
Administration of antiretroviral drugs to individuals exposed to, but not infected by, HIV has been shown to reduce the risk of transmission. The efficacy of pre-exposure prophylaxis (PrEP) makes it obligatory to include it in an integral program of prevention of HIV transmission, together with other measures, such as use of the condom, training, counseling, and appropriate treatment of infected individuals. In this document, the AIDS Study Group (GeSIDA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica [SEIMC]) provides its views on this important subject...
June 2017: Enfermedades Infecciosas y Microbiología Clínica
Javier Ariza, Javier Cobo, Josu Baraia-Etxaburu, Natividad Benito, Guillermo Bori, Javier Cabo, Pablo Corona, Jaime Esteban, Juan Pablo Horcajada, Jaime Lora-Tamayo, Oscar Murillo, Julián Palomino, Jorge Parra, Carlos Pigrau, José Luis Del Pozo, Melchor Riera, Dolores Rodríguez, Mar Sánchez-Somolinos, Alex Soriano, M Dolores Del Toro, Basilio de la Torre
The incidence of prosthetic joint infection (PJI) is expected to increase in the coming years. PJI has serious consequences for patients, and high costs for the health system. The complexity of these infections makes it necessary to organize the vast quantity of information published in the last several years. The indications for the choice of a given surgical strategy and the corresponding antimicrobial therapy are specifically reviewed. The authors selected clinically relevant questions and then reviewed the available literature in order to give recommendations according to a pre-determined level of scientific evidence...
March 2017: Enfermedades Infecciosas y Microbiología Clínica
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January 2017: Enfermedades Infecciosas y Microbiología Clínica
J A Pineda, L E Morano-Amado, R Granados, J Macías, F Téllez, M García-Deltoro, M J Ríos, A Collado, M Delgado-Fernández, M Suárez-Santamaría, M Serrano, C Miralles-Álvarez, K Neukam
OBJECTIVE: The aim of this study was to determine the predictive capacity of response at treatment week (TW) 4 for the achievement of sustained virological response 12 weeks after the scheduled end of therapy date (SVR12) to treatment against hepatitis C virus (HCV) genotype 3 (GT3) infection with all-oral direct-acting antiviral (DAA) -based regimens. PATIENTS AND METHODS: From a prospective multicohort study, HCV GT3-infected patients who completed a course of currently recommended DAA-based therapy at 33 Spanish hospitals and who had reached the SVR12 evaluation time-point were selected...
June 2017: Clinical Microbiology and Infection
K Neukam, L E Morano-Amado, A Rivero-Juárez, J Macías, R Granados, A Romero-Palacios, M Márquez, D Merino, E Ortega, J C Alados-Arboledas, J Cucurull, M Omar, P Ryan-Murua, J A Pineda
The purpose of this investigation was to evaluate the impact of liver stiffness (LS) on the response to direct-acting antiviral (DAA)-based therapy against hepatitis C virus (HCV) infection in cirrhotic patients. Those patients included in two Spanish prospective cohorts of patients receiving therapy based on at least one DAA, who showed a baseline LS ≥ 12.5 kPa and who had reached the scheduled time point for sustained virological response evaluation 12 weeks after completing therapy (SVR12) were analysed...
May 2017: European Journal of Clinical Microbiology & Infectious Diseases
Claudio Hernández Mosqueira, Dagoberto Hernández Vasquez, Alexis Caniuqueo Vargas, Humberto Castillo Quezada, Sandro Fernandes Da Silva, Gustavo Pavez-Adasme, Cristian Martínez Salazar, Jaime Cárcamo-Oyarzún, José Fernandes Filho
Introducción: Chile en las últimas décadas ha experimentado un cambio en su perfil epidemiológico nutricional, pasando de una situación caracterizada por una elevada prevalencia de desnutrición y enfermedades infecciosas/parasitarias a otro completamente distinto, en donde las enfermedades crónicas y degenerativas presentan una elevada prevalencia.Objetivo: el objetivo del estudio es elaborar tablas de referencia de aspectos antropométricos y de condición física en estudiantes varones de 10 a 14 años de la ciudad de Chillán...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Nicolás Merchante, Antonio Rivero-Juárez, Francisco Téllez, Dolores Merino, Maria José Ríos-Villegas, Guillermo Ojeda-Burgos, Mohamed Omar, Juan Macías, Antonio Rivero, Monserrat Pérez-Pérez, Miguel Raffo, Inmaculada López-Montesinos, Manuel Márquez-Solero, Maria Amparo Gómez-Vidal, Juan A Pineda
BACKGROUND: A liver stiffness below 21 kPa has a high negative predictive value to exclude the presence of esophageal varices at risk of bleeding in HIV/hepatitis C virus (HCV)-coinfected patients. Consequently, upper gastrointestinal endoscopy (UGE) for the screening of esophageal varices could be avoided in these patients. However, this strategy has not been widely accepted due to concerns about its safety. OBJECTIVE: To assess the ability of liver stiffness to predict the risk of portal hypertensive gastrointestinal bleeding (PHGB) in HIV/HCV-coinfected patients with compensated cirrhosis...
February 20, 2017: AIDS
A Rivero-Juarez, L F Lopez-Cortes, M Castaño, D Merino, M Marquez, M Mancebo, F Cuenca-Lopez, P Jimenez-Aguilar, I Lopez-Montesinos, S Lopez-Cardenas, A Collado, M A Lopez-Ruz, M Omar, F Tellez, X Perez-Stachowski, J Hernandez-Quero, J A Girón-Gonzalez, E Fernandez-Fuertes, A Rivero
In April 2015, the Spanish National Health System (SNHS) developed a national strategic plan for the diagnosis, treatment, and management of hepatitis C virus (HCV). Our aim was to analyze the impact of this on human immunodeficiency virus (HIV)-infected patients included in the HERACLES cohort during the first 6 months of its implementation. The HERACLES cohort (NCT02511496) was set up in March 2015 to evaluate the status and follow-up of chronic HCV infection in patients co-infected with HIV in the south of Spain...
March 2017: European Journal of Clinical Microbiology & Infectious Diseases
Miguel Santin, José-María García-García, David Rigau, Neus Altet, Luis Anibarro, Irma Casas, Nuria Díez, Mercedes García-Gasalla, Xavier Martínez-Lacasa, Antón Penas, Elvira Pérez-Escolano, Francisca Sánchez, José Domínguez
Interferon-gamma release assays are widely used for the diagnosis of tuberculosis infection in Spain. However, there is no consensus on their application in specific clinical scenarios. To develop a guide-line for their use, a panel of experts comprising specialists in infectious diseases, respiratory diseases, microbiology, pediatrics and preventive medicine, together with a methodologist, conducted a systematic literature search, summarized the findings, rated the quality of the evidence, and formulated recommendations following the Grading of Recommendations of Assessment Development and Evaluations methodology...
September 2016: Archivos de Bronconeumología
Karin Neukam, José A Mira, Antonio Collado, Antonio Rivero-Juárez, Patricia Monje-Agudo, Josefa Ruiz-Morales, María José Ríos, Dolores Merino, Francisco Téllez, Inés Pérez-Camacho, María Carmen Gálvez-Contreras, Antonio Rivero, Juan A Pineda
OBJECTIVE: To assess the current frequency of ART-associated grade 3-4 transaminase elevations (TE) and grade 4 total bilirubin elevations (TBE) in HIV-infected patients with chronic hepatitis B and/or C, who start a new regimen of ART. PATIENTS AND METHODS: A total of 192 pre-treated or treatment-naive HIV infected patients with HBV and/or HCV-coinfection who started ART in eight Southern Spanish centers from July/2011-December/2013, were followed for 12 months in this prospective study...
2016: PloS One
Nicolás Merchante, Francisco Téllez, Antonio Rivero-Juárez, Maria José Ríos-Villegas, Dolores Merino, Manuel Márquez-Solero, Mohamed Omar, Eva Recio, Montserrat Pérez-Pérez, Ángela Camacho, Sara Macías-Dorado, Juan Macías, Sandra Lorenzo-Moncada, Antonio Rivero, Juan A Pineda
BACKGROUND: Our objective was to assess the predictive value of the changes of liver stiffness (LS) for clinical outcome in HIV/HCV-coinfected patients with compensated liver cirrhosis and a LS value < 40 kPa. METHODS: Prospective cohort of 275 HIV/HCV-coinfected patients with cirrhosis, no previous liver decompensation (LD) and LS < 40 kPa. The time from diagnosis to LD and/or hepatocellular carcinoma (HCC) and the predictors of this outcome were evaluated...
2015: BMC Infectious Diseases
A Rivero-Juarez, A Gutierrez-Valencia, M Castaño, D Merino, K Neukam, M J Ríos-Villegas, M A Lopez-Ruz, P Jiménez-Aguilar, M Marquez, A Collado, A Gomez-Vidal, J Hernandez-Quero, F Tellez, E Fernandez-Fuertes, A Rivero, L F López-Cortés
The implementation of hepatitis C (HCV) direct-acting antiviral drugs is prioritized in several populations in which its application provides the most immediate and impactful benefit. In this scenario, a precise knowledge of the situation of human immunodeficiency virus (HIV)/HCV chronic co-infection is required to adequately address this disease. This cross-sectional study was performed in 21 hospitals in Andalusia (Spain). The study population consisted of HIV-infected patients with an active HCV chronic infection who were not receiving HCV treatment at the time of inclusion...
November 2015: European Journal of Clinical Microbiology & Infectious Diseases
Sergio Alberto Ramirez-Garcia, Luis Javier Flores-Alvarado, Luz Rosalba Topete-González, Claudia Charles-Niño, Manuel Mazariegos-Rubi, Nory Omayra Dávalos-Rodríguez
BACKGROUND: TJP1 gene encodes a ZO-1 protein that is required for the recruitment of occludins and claudins in tight junction, and is involved in cell polarisation. It has different variations, the frequency of which has been studied in different populations. In Mexico there are no studies of this gene. These are required because their polymorphisms can be used in studies associated with medicine and surgery. Therefore, the aim of this study was to estimate the frequency of alleles and genotypes of rs2291166 gene polymorphism TJP1 in Mexico Mestizos population, and to estimate the conformational effect of an amino acid change...
January 2016: Cirugia y Cirujanos
A Rivero-Juarez, A Caruz, L M Real, L Martinez-Dueñas, F J Marquez, M Frias, E Recio, A Gordon, J A Pineda, A Rivero, A Camacho
Hepatitis C virus (HCV) viral persistence in patients with spontaneous viral clearance is controversial. Several studies have shown HCV-RNA in peripheral blood mononuclear cells (PBMCs) and/or liver tissue among patients who have cleared the virus spontaneously, suggesting that viral persistence is a common situation that could involve the entire population studied. Thus, our aim was to evaluate HCV-RNA persistence in PBMCs and hepatocytes in subjects infected with the human immunodeficiency virus (HIV). A total of 1508 patients were prospectively followed and tested for anti-HCV antibodies and HCV-RNA to identify the patients who achieved spontaneous viral clearance...
November 2015: European Journal of Clinical Microbiology & Infectious Diseases
P Monje-Agudo, A Castro-Iglesias, A Rivero-Juárez, F Martínez-Marcos, E Ortega-González, L M Real, B Pernas, N Merchante, P Cid, J Macías, M D Merino, A Rivero, A Mena, K Neukam, J A Pineda
It is commonly accepted that human immunodeficiency (HIV) coinfection negatively impacts on the rates of sustained virological response (SVR) to therapy with pegylated interferon plus ribavirin (PR). However, this hypothesis is derived from comparing different studies. The aim of this study was to determine the impact of HIV coinfection on SVR to PR in one single population. In a multicentric, prospective study conducted between 2000 and 2013, all previously naïve hepatitis C virus (HCV)-infected patients who started PR in five Spanish hospitals were analyzed...
October 2015: European Journal of Clinical Microbiology & Infectious Diseases
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