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Enfermedades infecciosas

Miguel Santin, José-María García-García, David Rigau, Neus Altet, Luis Anibarro, Irma Casas, Nuria Díez, Mercedes García-Gasalla, Xavier Martínez-Lacasa, Antón Penas, Elvira Pérez-Escolano, Francisca Sánchez, José Domínguez
Interferon-gamma release assays are widely used for the diagnosis of tuberculosis infection in Spain. However, there is no consensus on their application in specific clinical scenarios. To develop a guide-line for their use, a panel of experts comprising specialists in infectious diseases, respiratory diseases, microbiology, pediatrics and preventive medicine, together with a methodologist, conducted a systematic literature search, summarized the findings, rated the quality of the evidence, and formulated recommendations following the Grading of Recommendations of Assessment Development and Evaluations methodology...
September 2016: Archivos de Bronconeumología
Karin Neukam, José A Mira, Antonio Collado, Antonio Rivero-Juárez, Patricia Monje-Agudo, Josefa Ruiz-Morales, María José Ríos, Dolores Merino, Francisco Téllez, Inés Pérez-Camacho, María Carmen Gálvez-Contreras, Antonio Rivero, Juan A Pineda
OBJECTIVE: To assess the current frequency of ART-associated grade 3-4 transaminase elevations (TE) and grade 4 total bilirubin elevations (TBE) in HIV-infected patients with chronic hepatitis B and/or C, who start a new regimen of ART. PATIENTS AND METHODS: A total of 192 pre-treated or treatment-naive HIV infected patients with HBV and/or HCV-coinfection who started ART in eight Southern Spanish centers from July/2011-December/2013, were followed for 12 months in this prospective study...
2016: PloS One
Nicolás Merchante, Francisco Téllez, Antonio Rivero-Juárez, Maria José Ríos-Villegas, Dolores Merino, Manuel Márquez-Solero, Mohamed Omar, Eva Recio, Montserrat Pérez-Pérez, Ángela Camacho, Sara Macías-Dorado, Juan Macías, Sandra Lorenzo-Moncada, Antonio Rivero, Juan A Pineda
BACKGROUND: Our objective was to assess the predictive value of the changes of liver stiffness (LS) for clinical outcome in HIV/HCV-coinfected patients with compensated liver cirrhosis and a LS value < 40 kPa. METHODS: Prospective cohort of 275 HIV/HCV-coinfected patients with cirrhosis, no previous liver decompensation (LD) and LS < 40 kPa. The time from diagnosis to LD and/or hepatocellular carcinoma (HCC) and the predictors of this outcome were evaluated...
2015: BMC Infectious Diseases
A Rivero-Juarez, A Gutierrez-Valencia, M Castaño, D Merino, K Neukam, M J Ríos-Villegas, M A Lopez-Ruz, P Jiménez-Aguilar, M Marquez, A Collado, A Gomez-Vidal, J Hernandez-Quero, F Tellez, E Fernandez-Fuertes, A Rivero, L F López-Cortés
The implementation of hepatitis C (HCV) direct-acting antiviral drugs is prioritized in several populations in which its application provides the most immediate and impactful benefit. In this scenario, a precise knowledge of the situation of human immunodeficiency virus (HIV)/HCV chronic co-infection is required to adequately address this disease. This cross-sectional study was performed in 21 hospitals in Andalusia (Spain). The study population consisted of HIV-infected patients with an active HCV chronic infection who were not receiving HCV treatment at the time of inclusion...
November 2015: European Journal of Clinical Microbiology & Infectious Diseases
Sergio Alberto Ramirez-Garcia, Luis Javier Flores-Alvarado, Luz Rosalba Topete-González, Claudia Charles-Niño, Manuel Mazariegos-Rubi, Nory Omayra Dávalos-Rodríguez
BACKGROUND: TJP1 gene encodes a ZO-1 protein that is required for the recruitment of occludins and claudins in tight junction, and is involved in cell polarisation. It has different variations, the frequency of which has been studied in different populations. In Mexico there are no studies of this gene. These are required because their polymorphisms can be used in studies associated with medicine and surgery. Therefore, the aim of this study was to estimate the frequency of alleles and genotypes of rs2291166 gene polymorphism TJP1 in Mexico Mestizos population, and to estimate the conformational effect of an amino acid change...
January 2016: Cirugia y Cirujanos
A Rivero-Juarez, A Caruz, L M Real, L Martinez-Dueñas, F J Marquez, M Frias, E Recio, A Gordon, J A Pineda, A Rivero, A Camacho
Hepatitis C virus (HCV) viral persistence in patients with spontaneous viral clearance is controversial. Several studies have shown HCV-RNA in peripheral blood mononuclear cells (PBMCs) and/or liver tissue among patients who have cleared the virus spontaneously, suggesting that viral persistence is a common situation that could involve the entire population studied. Thus, our aim was to evaluate HCV-RNA persistence in PBMCs and hepatocytes in subjects infected with the human immunodeficiency virus (HIV). A total of 1508 patients were prospectively followed and tested for anti-HCV antibodies and HCV-RNA to identify the patients who achieved spontaneous viral clearance...
November 2015: European Journal of Clinical Microbiology & Infectious Diseases
P Monje-Agudo, A Castro-Iglesias, A Rivero-Juárez, F Martínez-Marcos, E Ortega-González, L M Real, B Pernas, N Merchante, P Cid, J Macías, M D Merino, A Rivero, A Mena, K Neukam, J A Pineda
It is commonly accepted that human immunodeficiency (HIV) coinfection negatively impacts on the rates of sustained virological response (SVR) to therapy with pegylated interferon plus ribavirin (PR). However, this hypothesis is derived from comparing different studies. The aim of this study was to determine the impact of HIV coinfection on SVR to PR in one single population. In a multicentric, prospective study conducted between 2000 and 2013, all previously naïve hepatitis C virus (HCV)-infected patients who started PR in five Spanish hospitals were analyzed...
October 2015: European Journal of Clinical Microbiology & Infectious Diseases
J A Mira, K Neukam, L F López-Cortés, A Rivero-Juárez, F Téllez, J A Girón-González, I de los Santos-Gil, G Ojeda-Burgos, D Merino, M J Ríos-Villegas, A Collado, A Torres-Cornejo, J Macías, A Rivero, M Pérez-Pérez, J A Pineda
The aim of this study was to assess the efficacy of and the risk of major bleeding during pegylated interferon (peg-IFN)/ribavirin (RBV) treatment among human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients according to the pretreatment platelet count. Two hundred and seventy-four HCV/HIV-coinfected, previously naïve individuals with compensated cirrhosis enrolled in one Spanish prospective cohort who received peg-IFN/RBV were included in this study. The frequency of severe bleeding and sustained virological response (SVR) rate were compared between patients with a pretreatment platelet count ≤70,000/mm(3) and >70,000/mm(3), respectively...
September 2015: European Journal of Clinical Microbiology & Infectious Diseases
José Manuel Ramos, Gregorio González-Alcaide, Félix Gutiérrez
INTRODUCTION: The bibliometric analysis of production and impact of documents by knowledge area is a quantitative and qualitative indicator of research activity in this field. The aim of this article is to determine the contribution of Spanish research institutions in Infectious Diseases and Microbiology in recent years. MATERIAL AND METHODS: Documents published in the journals included in the categories "Infectious Diseases" and "Microbiology" of the Web of Science (Science Citation Index Expanded) of the ISI Web of Knowledge from the year 2000-2013 were analysed...
March 2016: Enfermedades Infecciosas y Microbiología Clínica
David V McQueen
No abstract text is available yet for this article.
June 2015: Global Health Promotion
José A Pérez-Molina, Federico Pulido
INTRODUCTION: The entry into force of Royal Decree (RD) 16/2012 in Spain in September 2012 led to the exclusion of the group of irregular immigrants from the National Healthcare System. With this work, GESIDA attempts to measure the impact of the entry into force of the RD in relation to its application by the Autonomous Communities (CCAA), and how it has affected the health care of irregular immigrants infected with HIV. METHODS: Information was requested from the 17 CCAA of the existence of measures to ensure the care and treatment of people with HIV infection that were left unprotected because of the implementation of the RD...
August 2015: Enfermedades Infecciosas y Microbiología Clínica
S Alfayate-Miguélez, J Ruiz Gómez, M Sanchez-Solis de Querol, C Guerrero Gómez, M Pérez Simón, M M Ortiz Romero, M L Núñez Trigueros, M L López Yepes, A Blazquez Abellán, J M Zarauz García, G Ruiz Merino, M P Ortuño del Moral
INTRODUCTION AND OBJECTIVES: Streptococcus pneumoniae (SP) is a human pathogen that involves a high use of antibiotics. The objective of the study was to determine the susceptibility to commonly used antibiotics and their associated risk factors, in order to promote rational use of antibiotics. PATIENTS AND METHODS: In A multicentre study was conducted in summer 2009 and winter 2010 on children attending paediatric clinics in the Region of Murcia. A nasopharyngeal sample was collected and an epidemiological questionnaire was completed...
September 2015: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
José L Gorriz, Félix Gutiérrez, Joan C Trullàs, Piedad Arazo, Jose R Arribas, Guillermina Barril, Miguel Cervero, Frederic Cofán, Pere Domingo, Vicente Estrada, Xavier Fulladosa, María J Galindo, Sílvia Gràcia, José A Iribarren, Hernando Knobel, José López-Aldeguer, Fernando Lozano, Alberto Martínez-Castelao, Esteban Martínez, Maria A Mazuecos, Celia Miralles, Rosario Montañés, Eugenia Negredo, Rosario Palacios, María J Pérez-Elías, Joaquín Portilla, Manuel Praga, Carlos Quereda, Antonio Rivero, Juan M Santamaría, José Sanz, Jesús Sanz, José M Miró
The aim of this article is to update the 2010 recommendations on the evaluation and management of renal disease in human immunodeficiency virus (HIV)-infected patients. Renal function should be monitored in all HIV-infected patients. The basic renal work-up should include measurements of serum creatinine, estimated glomerular filtration rate by CKD-EPI, urine protein-to-creatinine ratio, and urinary sediment. Tubular function tests should include determination of serum phosphate levels and urine dipstick for glycosuria...
November 2014: Enfermedades Infecciosas y Microbiología Clínica
Santiago Alfayate-Miguélez, Joaquín Ruiz-Gómez, Asunción Fenoll-Comes, Manuel Sanchez-Solis-de Querol, Antonio Iofrío-de Arce, Angela Casquet-Barceló, Gonzalo Sanz-Mateo, Pilar Espejo-García, Sebastián Lorente-García, Rosa M Sánchez-Andrada, Juan José Vigueras-Abellán
BACKGROUND AND OBJECTIVES: Streptococcus pneumoniae is a human pathogen that requires prior nasopharyngeal colonization to cause disease. An epidemiological study was conducted on nasopharyngeal carriers of pneumococci in healthy children in Murcia after the introduction of the VCN7, and immediately before the marketing of new vaccines, with the aim of determining the influence of vaccination in our geographic area, and other factors in relation to the state of being a carrier, and the different circulating serotypes...
August 2014: Enfermedades Infecciosas y Microbiología Clínica
M Eulalia Lucio-Villegas Menéndez, Laura López González, M Isabel Gutiérrez Pérez, Natalia Aresté Lluch, M Luisa Morató Agustí, Santiago Pérez Cachafeiro
In wound care, knowing what to do is as important as knowing what not to do. The first step is to evaluate the severity of the lesion and to know whether it is necessary to attend a health center or not. If the wound is simple, the recommended course of action is cleansing with serum or water after washing one's hands, followed by wound disinfection with the most appropriate antiseptic. Antiseptics not should be used for wound cleansing (physiological serum or tap water should be used) or for wound healing with granulation tissue...
May 2014: Atencion Primaria
M Isabel Gutiérrez Pérez, M Eulalia Lucio-Villegas Menéndez, Laura López González, Natalia Aresté Lluch, M Luisa Morató Agustí, Santiago Pérez Cachafeiro
Wounds can be classified according to their mechanism of action into surgical or traumatic (which may be incision wounds, such as those provoked by a sharp object; contusions, caused by a blunt force; puncture wounds, caused by long, sharp objects; lacerations, caused by tears to the tissue; or bites, which have a high risk of infection and consequently should not be sutured). Wounds can also be classified by their healing process into acute or chronic (pressure ulcers, vascular ulcers, neuropathic ulcers, acute wounds with torpid clinical course)...
May 2014: Atencion Primaria
Laura López González, M Isabel Gutiérrez Pérez, M Eulalia Lucio-Villegas Menéndez, Natalia Aresté Lluch, M Luisa Morató Agustí, Santiago Pérez Cachafeiro
Antiseptics are anti-infectious agents for local use on the skin or mucosa, which distinguishes them from disinfectants, which are used on inanimate surfaces usually because of their toxicity. The present article explains the differences among the multiple possible antiseptics; special attention is paid to the most common, such as alcohol, chlorhexidine, povidone iodine, and oxygenated water. Finally, we stress the different antiseptic formulations, which increase the usefulness of these agents in specific indications...
May 2014: Atencion Primaria
Luis F López-Cortés, Pompeyo Viciana, José A Girón-González, Alberto Romero-Palacios, Manuel Márquez-Solero, Maria A Martinez-Perez, Miguel A López-Ruz, Javier de la Torre-Lima, Francisco Téllez-Pérez, Marcial Delgado-Fernández, Milagros Garcia-Lázaro, Fernando Lozano, Mohamed O Mohamed-Balghata
UNLABELLED: Etravirine (ETV) is recommended in combination with a boosted protease inhibitor plus an optimized background regimen for salvage therapy, but there is limited experience with its use in combination with two nucleos(t)ide reverse-transcriptase inhibitors (NRTIs). This multicenter study aimed to assess the efficacy of this combination in two scenarios: group A) subjects without virologic failure on or no experience with non-nucleoside reverse-transcriptase inhibitors (NNRTIs) switched due to adverse events and group B) subjects switched after a virologic failure on an efavirenz- or nevirapine-based regimen...
2014: PloS One
Antonio Rivero-Juarez, Luis F López-Cortés, Angela Camacho, Jose A Mira, Francisco Téllez, Manuel Marquez, Dolores Merino, Juan A Pineda, Antonio Rivero
We designed a study to evaluate the efficacy of a 24-week treatment strategy in HIV/hepatitis C virus (HCV) genotype 3-coinfected patients achieving rapid virologic response for a first HCV treatment with pegylated interferon plus ribavirin (peg-IFN/RBV). Our results suggest that a shorter course of peg-IFN/RBV therapy may be sufficient in this population.
January 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Pilar Retamar, María Dolores López-Prieto, Clara Nátera, Marina de Cueto, Enrique Nuño, Marta Herrero, Fernando Fernández-Sánchez, Angel Muñoz, Francisco Téllez, Berta Becerril, Ana García-Tapia, Inmaculada Carazo, Raquel Moya, Juan E Corzo, Laura León, Leopoldo Muñoz, Jesús Rodríguez-Baño, Fernando Rodríguez-López, María V García, Verónica Fernández-Galán, Alfonso del Arco, María J Pérez-Santos, Antonio Sánchez Porto, Manuel Torres-Tortosa, Andrés Martín-Aspas, Ascensión Arroyo, Carolina García-Figueras, Federico Acosta, Carmen Florez, Petra Navas, Trinidad Escobar-Lara
BACKGROUND: Healthcare-associated (HCA) bloodstream infections (BSI) have been associated with worse outcomes, in terms of higher frequencies of antibiotic-resistant microorganisms and inappropriate therapy than strict community-acquired (CA) BSI. Recent changes in the epidemiology of community (CO)-BSI and treatment protocols may have modified this association. The objective of this study was to analyse the etiology, therapy and outcomes for CA and HCA BSI in our area. METHODS: A prospective multicentre cohort including all CO-BSI episodes in adult patients was performed over a 3-month period in 2006-2007...
2013: BMC Infectious Diseases
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