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https://www.readbyqxmd.com/read/13357542/synapses-in-the-central-nervous-system
#1
S L PALAY
A number of different synapses have been described in the medulla, cerebellar cortex, and cerebral cortex of the rat. All of these possess the same fundamental fine structure as follows: 1. Close apposition of the limiting membranes of presynaptic and postsynaptic cells without any protoplasmic continuity across the synapse. The two apposed membranes are separated by a cleft about 200 A wide, and display localized regions of thickening and increased density. 2. The presynaptic expansion of the axon, the end-foot or bouton terminal, contains a collection of mitochondria and clusters of small vesicles about 200 to 650 A in diameter...
July 25, 1956: Journal of Biophysical and Biochemical Cytology
https://www.readbyqxmd.com/read/7006458/immunohistochemical-localization-of-serotonin-nerve-terminals-in-the-lateral-entorhinal-cortex-of-the-rat-demonstration-of-two-separate-patterns-of-innervation-from-the-midbrain-raphe
#2
C Köhler, V Chan-Palay, L Haglund, H Steinbusch
The distribution of serotonin (5-hydroxytryptamine, 5HT) containing nerve terminals in the lateral entorhinal cortex (LEC) has been studied using antibodies against 5-HT in combination with fluorescence histochemistry. Thin, varicose, branching fibers were found to be distributed in a relatively even, diffuse pattern throughout all layers of the LEC. The largest amount of this type of 5HT innervation was in Layer I. This diffuse pattern of 5-HT terminals was supplemented by a dense network of 5HT terminals restricted to Layer III of a small (approximately 1 mm) strip of the LEC...
1980: Anatomy and Embryology
https://www.readbyqxmd.com/read/3522662/distribution-of-neurons-and-axons-immunoreactive-with-antisera-against-neuropeptide-y-in-the-normal-human-hippocampus
#3
V Chan-Palay, C Köhler, U Haesler, W Lang, G Yasargil
The detailed distribution of neuropeptide tyrosine (neuropeptide Y; NPY) immunoreactive neurons and fibers is given for the normal human hippocampus. These neuronal elements are detected by a polyclonal antibody raised against the unconjugated peptide and controls were obtained by using liquid phase absorption immunocytochemistry. The description covers the distribution in the area dentata, the hippocampal subfields CA3 and CA1, the subicular complex, and the entorhinal area. Each region is distinct in its NPY content...
June 15, 1986: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/3230045/techniques-for-the-simultaneous-demonstrations-of-neuropeptide-y-gene-expression-and-peptide-storage-in-single-neurons-of-the-human-brain
#4
V Chan-Palay
The distribution of mRNA encoding neuropeptide Y (NPY) in neurons of the normal human cerebral cortex in surgical biopsy specimens and postmortem brain was studied by in situ hybridization techniques. A 32P-labeled complementary RNA (cRNA) probe was used on cryostat sections of formaldehyde-fixed cortical biopsy specimens. Hybridization to NPY mRNA was found in all samples: after autoradiography, discrete deposits of silver granules were observed on neuronal cell bodies abundantly distributed in the deep layers of the cortex, particularly laminae IV and VI, and on smaller cell bodies in the white matter...
1988: Histochemistry
https://www.readbyqxmd.com/read/2886516/somatostatin-immunoreactive-neurons-in-the-human-hippocampus-and-cortex-shown-by-immunogold-silver-intensification-on-vibratome-sections-coexistence-with-neuropeptide-y-neurons-and-effects-in-alzheimer-type-dementia
#5
V Chan-Palay
The distribution of somatostatinlike immunoreactivity was studied in the hippocampal formation, retrohippocampal region, and temporal cortex in the human brain. Tissues from surgical biopsy and postmortem cases were used, and the immunogold/silver method on vibratome sections was introduced for routine applications in conjunction with primary antisera that recognise somatostatin-14 or somatostatin-28. Somatostatin-28 antisera readily stained numerous neurons, dendrites, and extensive axonal networks throughout the hippocampus and neighbouring cortex...
June 8, 1987: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/2444979/localization-of-neuropeptide-y-mrna-in-neurons-of-human-cerebral-cortex-by-means-of-in-situ-hybridization-with-a-complementary-rna-probe
#6
G Terenghi, J M Polak, Q Hamid, E O'Brien, P Denny, S Legon, J Dixon, C D Minth, S L Palay, G Yasargil
The distribution of mRNA encoding neuropeptide Y (NPY) in neurons of the normal human cerebral cortex in surgical biopsy specimens and postmortem brain was studied by in situ hybridization techniques. A 32P-labeled complementary RNA (cRNA) probe was used on cryostat sections of 13 formaldehyde-fixed cortical biopsy specimens. Hybridization to NPY mRNA was found in all samples: after autoradiography, discrete deposits of silver granules were observed on neuronal cell bodies abundantly distributed in the deep layers of the cortex, particularly laminae IV and VI, and on smaller cell bodies in the white matter...
October 1987: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/2422984/immunocytochemistry-of-human-brain-tissue-with-a-polyclonal-antiserum-against-neuropeptide-y
#7
COMPARATIVE STUDY
V Chan-Palay, G Yasargil
NPY-containing neuronal structures in the cerebral cortex of surgical tissue samples were compared to those in postmortem material by immunocytochemical methods. However, the quality of preservation of individual neurons and axonal and dendritic plexuses in the neuropil is unusually fine in the surgical specimens. This result is most likely attributable to the excellent fixation that can be regularly achieved by rapid and careful handling of tissue during and after surgical removal. The tissue is suitable for both light and electron microscopy, and the superior preservation also leads to intense, reliable antibody reactions...
1986: Anatomy and Embryology
https://www.readbyqxmd.com/read/2413088/cortical-neurons-immunoreactive-with-antisera-against-neuropeptide-y-are-altered-in-alzheimer-s-type-dementia
#8
COMPARATIVE STUDY
V Chan-Palay, W Lang, Y S Allen, U Haesler, J M Polak
Neurons identified by their immunoreactivity with antisera against neuropeptide Y (NPY) were studied in three selected areas of the cerebral cortex in brains from controls and in senile dementia of the Alzheimer type (ATD). Changes were more profound in temporal cortex than in parietal cortex, and more severe in parietal cortex than in frontal cortex, paralleling the severity of neuritic plaque formation and incidence of neurofibrillary tangles in these regions. NPY-i neurons became distorted, with enlarged misshapen cell somata and reduced, thickened, and gnarled dendrites...
August 22, 1985: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/2413087/cytology-and-distribution-in-normal-human-cerebral-cortex-of-neurons-immunoreactive-with-antisera-against-neuropeptide-y
#9
V Chan-Palay, Y S Allen, W Lang, U Haesler, J M Polak
The frontal, parietal, and temporal cortices in normal human brains (Brodmann areas 10, 7a, 7b, and 21) are well endowed with numerous neurons, identifiable by immunoreactivity with antisera against the 36-amino acid brain peptide neuropeptide Y (NPY). These neurons with rare exception are small, intracortical, nonspiny neurons, 12-20 microns in somatic size, with long slender dendrites and exuberant axon plexuses exhibiting finely beaded varicosities. The cells are rarest in layers I and II, are found with frequency in the lower cortical layers (IV-VI) and in significant numbers in the subcortical white matter...
August 22, 1985: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/903429/a-study-of-afferent-input-to-the-inferior-olivary-complex-in-the-rat-by-retrograde-axonal-transport-of-horseradish-peroxidase
#10
J T Brown, V Chan-Palay, S L Palay
No abstract text is available yet for this article.
November 1, 1977: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/813816/serotonin-axons-in-the-supra-and-subependymal-plexuses-and-in-the-leptomeninges-their-roles-in-local-alterations-of-cerebrospinal-fluid-and-vasomotor-activity
#11
V Chan-Palay
Extensive plexuses of serotonin axons form a supra- and subependymal system in the walls of the ventricles, in the arachnoid sheath around major cerebral blood vessels, and in the pia over the spinal cord. These have been demonstrated by autoradiography after continuous intraventricular perfusions of exogenous [3H]5-HT in rats and monkeys. The axons accumulate 5,6-DHT rendering them electron opaque, but have no uptake systems for [3H]NE. After treatment with MAO inhibitors and [3H]5-HT, the axonal boutons contain large (70nm) variably dense synaptic vesicles, and small (35 nm) vesicles each equipped with a dense dot...
January 30, 1976: Brain Research
https://www.readbyqxmd.com/read/273213/autoradiographic-localization-of-gamma-aminobutyric-acid-receptors-in-the-rat-central-nervous-system-by-using-3h-muscimol
#12
V Chan-Palay
Muscimol, a structural analogue and potent agonist of gamma-aminobutyric acid (GABA), was used in its tritiated form for the autoradiographic localization of GABA receptors in the rat central nervous system. [(3)H]Muscimol ([(3)H]M) was incubated with brain slices or was injected intracortically or into intraocular brain transplants. As indicated by [(3)H]M binding and autoradiographic silver grains, GABA receptors display a laminar distribution over the cerebellar cortex, cerebral cortex, and hippocampus (in order of decreasing quantity); and a nonlaminar distribution in the caudate nucleus and substantia nigra...
February 1978: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/59655/a-guide-to-the-synaptic-analysis-of-the-neuropil
#13
REVIEW
S L Palay, V Chan-Palay
A morphological analysis of the organization of the gray matter in the central nervous system depends on the discovery of consistent repetitive patterns. Without these, the gray matter remains a chaotic jungle. An hypothesis derived from the study of a few simple regions has been developed to serve as a guide in finding these patterns. It states that all nerve fibers and terminals arising from a particular group of nerve cells, or, more precisely, a particular nerve cell type, display similar axoplasmic configurations despite variations in size and shape of the terminations...
1976: Cold Spring Harbor Symposia on Quantitative Biology
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