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Actinic keratosis

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https://www.readbyqxmd.com/read/28329662/the-preneoplastic-genome-transcriptomic-drivers-of-squamous-cell-carcinoma-development
#1
Kenneth Y Tsai
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in the U.S. annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). In order to identify potential targets for molecularly targeted chemoprevention, we performed integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar UV- driven Hairless mouse model. We performed RNA-seq and microRNA-seq on samples from both patients undergoing Mohs surgery and the mouse model...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329661/predictors-of-actinic-keratosis-count-in-those-with-multiple-keratinocyte-carcinomas
#2
Julia A Siegel, Adam J Luber, Martin A Weinstock
Actinic keratoses (AKs) are frequently treated in the U.S., impacting an estimated 40 million people in 2004 and costing over $1 billion annually. AKs are a major public health concern because of their high prevalence, substantial cost, and potential for malignant transformation to keratinocyte carcinoma (KC). In this analysis, predictors of AK count were explored using pre-randomization baseline data from two large randomized trials of veterans with multiple prior KCs (n=932 and n=1131). Multivariate analyses were conducted to elucidate associations between AK count and several demographic and health related factors...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329637/dermatological-screening-of-an-elderly-population-the-rotterdam-study
#3
Martijn G H Sanders, Joris A C Verkouteren, Luba M Pardo
BackgroundThe recent WHO burden of disease project showed that the non-fatal skin disease related burden is high, but also that prevalence rates of many common skin diseases are not well documented. The aim of this study is to give an overview of (untreated) skin diseases in a population based sample of elderly.MethodsIn 2010, a full body skin examination (FBSE) was embedded in the Rotterdam Study, a prospective population based cohort study of an elderly white-skinned population in the Netherlands. The examination was conducted by a dermatology-trained physician and focused on most common skin diseases (e...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329611/terap%C3%A3%C2%AAutica-fotodin%C3%A3-mica-com-metil-aminolevulinato-no-tratamento-de-les%C3%A3%C2%B5es-refract%C3%A3-rias-de-micose-fung%C3%A3-ide-resposta-cl%C3%A3-nica-e-histol%C3%A3-gica-mantida-em-dois-doentes
#4
Ana Isabel Teixeira, João Maia E Silva
According to the guidelines proposed by the National Comprehensive Cancer Network, early-stage Mycosis Fungoides (MF) should be treated with skin-directed therapies such as topical steroids or retinoids, topical chemotherapy (carmustin and nitrogen mustard), photochemotherapy, and superficial radiotherapy. Patients with refractory lesions to these therapeutic options are particularly challenging. Photodynamic Therapy (PDT) has been approved to treat cutaneous neoplastic and pre-neoplastic lesions such as superficial basal cell carcinoma, Bowen disease and actinic keratosis...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329576/5-fluorouracil-induced-exacerbation-of-rosacea
#5
Ellen S Haddock, Philip R Cohen
Background Topical 5-fluorouracil (5-FU) is an antineoplastic antimetabolite used for the treatment of actinic keratosis.Purpose A 66-year-old man with erythematotelangiectatic rosacea and biopsy-confirmed actinic keratoses who experienced a rosacea exacerbation after initiating topical 5-FU treatment of his actinic keratoses is described and this adverse event associated with 5-FU is reviewed.Materials and methods Using PubMed.gov the following terms were searched and relevant citations were assessed: rosacea and 5-fluorouracil...
November 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28327550/significant-role-of-collagen-xvii-and-integrin-%C3%AE-4-in-migration-and-invasion-of-the-less-aggressive-squamous-cell-carcinoma-cells
#6
Jyri M Moilanen, Stefanie Löffek, Nina Kokkonen, Sirpa Salo, Juha P Väyrynen, Tiina Hurskainen, Aki Manninen, Pilvi Riihilä, Ritva Heljasvaara, Claus-Werner Franzke, Veli-Matti Kähäri, Tuula Salo, Markus J Mäkinen, Kaisa Tasanen
Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We have studied the expression of laminin γ2, collagen XVII and integrin β4 in tissue microarray samples of squamous cell carcinoma (SCC) and its precursors, actinic keratosis and Bowen's disease...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301622/expert-consensus-on-cosmetic-outcomes-after-treatment-of-actinic-keratosis
#7
Brian Berman, Glynis R Ablon, Neal D Bhatia, Roger I Ceilley, David J Goldberg, Mark S Nestor, Susan H Weinkle
<p>Dermatologists treat actinic keratosis (AK) primarily because these lesions have the potential to progress to invasive squamous cell carcinoma. Patients, on the other hand, generally seek treatment to remove the lesions and achieve an improved appearance of their skin following treatment. In selecting a treatment option for AK, dermatologists should consider post-treatment cosmesis, because cosmetic outcomes differ across AK treatments. To obtain expert opinion on the cosmetic sequelae related to chronically photodamaged skin and the treatment of AK, an expert panel meeting among dermatologists was conducted in February 2016...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300852/regression-analysis-of-local-skin-reactions-to-predict-clearance-of-actinic-keratosis-on-the-face-in-patients-treated-with-ingenol-mebutate-gel-experience-from-randomized-controlled-trials
#8
Shelbi Jim On, Kim Mark Knudsen, Torsten Skov, Mark Lebwohl
<p>Ingenol mebutate gel, a topical field treatment for actinic keratosis (AK), elicits inflammatory application-site reactions in most patients. This analysis explored the relationship between the intensity of local skin reactions (LSRs) and AK clearance, measured by the reduction in AK count from baseline in 218 patients who were treated for AK on the face in the pivotal Phase 3 studies. The analysis modeled the AK count at week 8, adjusted for baseline count, with the composite LSR score at 1 day after the last treatment application for each patient as a predictor to estimate the mean and 90% prediction interval for the percent reduction in AK count...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28295705/re-the-freeze-thaw-cycle-in-cryosurgery
#9
David Buckley
I agree with Professor Zouboulis, in his article ''Is Cryosurgery Less Effective than Conservative Regimes in the Treatment of Actinic Keratosis?'' (1), when he argures that success rate when treating actinic keratosis with cryosurgery varies widely, largely because of a wide variation in the technique used. I have consistently achieved greater than 90% cure rates when using liquid nitrogen cryosurgery via a cryogun in the treatment of actinic keratosis, hand warts and plantar warts (2 and 3). As far back as 1982, Lubritze and colleagues were achieving a cure rate of greater than 98% after one year when treating actinic keratosis with liquid nitrogen cryosurgery (4)...
March 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28294419/management-of-cancerization-field-with-a-medical-device-containing-photolyase-a-randomized-double-blind-parallel-group-pilot-study
#10
Elvira Moscarella, Giuseppe Argenziano, Caterina Longo, Sonia Aladren
At least 6 clinical studies conducted in subjects with actinic keratosis (AK) have demonstrated the therapeutic effect of Eryfotona AK-NMSC(®) (ISDIN, Spain), a topically applied film-forming cream containing DNA Repairsomes(™) (broad-spectrum UV filters and the DNA-repair enzyme photolyase, encapsulated in liposomes) (1-6) (registered as medical device in Europe). Recently a German opinion paper reviewed clinical evidence for the efficacy of topical application of this topical cream. They concluded that there was strong evidence that patient at high risk for developing AK would benefit from the year around use of this product marketed in Europe in the medical device category...
March 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28287855/association-between-cataract-and-keratinocytic-skin-cancers-or-melanoma-speculating-on-the-common-role-of-sun-and-ultraviolet-radiation-exposures
#11
David Varssano, Mira Friedman, Michaella Goldstein, Shai Bar-Sela, Tal Sella, Varda Shalev, Gabriel Chodick
PURPOSE: Cataract and sun-related skin conditions are proxies to lifetime UV exposure. We examined the association between them using real-world data from an unselected Israeli population. METHODS: Computerized data was obtained from an Israeli health maintenance organization regarding cases of sun-related skin pathologies and cataract diagnosed between 2006 and 2011 in 686,260 members aged 40 or above. RESULTS: Sun-related skin disorders were found in 9...
March 13, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28267402/cd40-ligand-is-increased-in-mast-cells-in-psoriasis-and-actinic-keratosis-but-less-so-in-epithelial-skin-carcinomas
#12
Salla Haimakainen, Antti P Kaukinen, Mireille-Maria Suttle, Jukka Pelkonen, Ilkka T Harvima
The expression of CD40 ligand (CD40L) in mast cells was investigated in biopsies from lesional and non-lesional skin samples of patients with psoriasis, actinic keratosis (AK), basal cell carcinoma, and squamous cell carcinoma using a sequential double-staining technique. The percentage of CD40L(+) mast cells was higher in the lesional than in the non-lesional skin (p < .003). Interestingly, this percentage was lower in both carcinomas than in psoriasis and actinic keratosis (p < .025). Cells immunopositive for CD40 receptor were increased in all lesion types but especially so in carcinomas...
March 16, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28266938/follicular-porokeratosis-a-porokeratosis-variant
#13
Ben Tallon, Patrick Emanuel
Porokeratosis derives from a process of abnormal keratinization, resulting in clinical and histologic variants. Follicular involvement is infrequently described, with previous suggestions that it may represent a distinct condition. We describe a case of typical disseminated superficial actinic porokeratosis with additional clinically prominent folliculocentric keratosis. Histologically, this represented follicular cornoid lamellae. These findings support follicular porokeratosis as an anatomic site variant of porokeratosis, as opposed to a distinct condition...
February 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28264612/a-dose-finding-trial-with-a-novel-ingenol-derivative-ingenol-disoxate-leo-43204-for-field-treatment-of-actinic-keratosis-on-full-face-or-250cm-2-on-the-chest
#14
Marc Bourcier, Linda Stein Gold, Lyn Guenther, Camilla M Andreassen, Johan Selmer, Gary Goldenberg
PURPOSE: Actinic keratoses (AKs) may progress to squamous cell carcinoma and can occur in cancerized fields as sub-clinical and clinically visible lesions. Ingenol disoxate gel is a topical field therapy for AK. This Phase I/II trial aimed to assess the safety and efficacy of ingenol disoxate on full face or chest in patients with AKs. MATERIALS AND METHODS: Part 1 was a phase-I, open-label, dose-escalation trial investigating the maximum tolerated dose of ingenol disoxate...
March 7, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28263022/the-importance-of-patient-centred-care-to-overcome-barriers-in-the-management-of-actinic-keratosis
#15
REVIEW
R Cerio
Visible actinic keratosis (AK) lesions and subclinical (non-visible) sun damage in the field of cancerization are associated with risk of both non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), and, more rarely, melanoma. As the incidences of AK and skin cancer are increasing, effective prevention and treatment of AK is essential to minimize disease burden and improve patient quality of life. Currently, AK lesions are often left untreated and field therapies are underused...
March 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28263021/the-importance-of-treating-the-field-in-actinic-keratosis
#16
REVIEW
E Stockfleth
Actinic keratoses (AKs) are intraepithelial atypical proliferations of keratinocytes that develop in skin that has undergone long-term exposure to ultraviolet radiation. Given the ageing population and an increasing prevalence of AK, the socio-economic burden of AK is likely to rise over the coming years. Areas of subclinical (non-visible) sun damage in the periphery of visible AK lesions contain the same genetic changes as those found in the lesions themselves, and are known as areas of field cancerization...
March 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28263020/from-actinic-keratosis-to-squamous-cell-carcinoma-pathophysiology-revisited
#17
REVIEW
M T Fernandez Figueras
The precursor of most cutaneous invasive squamous cell carcinomas (iSCCs) is intraepithelial UV-induced damage, known as field cancerization, which can eventually transform into actinic keratosis (AK). Although AK is the most common precursor of iSCC, many AKs will either persist in the same stage or regress, while only a few will progress into iSCC. Nevertheless, because the progression of individual AKs cannot be predicted, it has been proposed that all AKs, regardless of the grade, should be carefully monitored and appropriately treated in clinical practice...
March 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28263019/what-lies-beneath-actinic-keratosis-looking-beyond-visible-lesions-to-optimize-patient-outcomes
#18
EDITORIAL
John T Lear
No abstract text is available yet for this article.
March 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28263018/treatment-considerations-in-actinic-keratosis
#19
REVIEW
G Goldenberg
The chronic skin condition actinic keratosis (AK) is characterized by the formation of keratotic lesions of variable thickness that are poorly delimited. AK occurs on areas of the skin that have had long-term exposure to the sun or UV radiation. Although AKs may regress, they usually persist and can progress to squamous cell carcinoma (SCC). Clinicians are unable to predict which AKs will progress; therefore, both clinically visible lesions and subclinical, non-visible (i.e. the entire area affected by AK/field cancerization) should be treated...
March 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28257944/a-quantitative-study-of-in-vivo-protoporphyrin-ix-fluorescence-build-up-during-occlusive-treatment-phases
#20
C Louise Campbell, C Tom A Brown, Kenneth Wood, Ana Gabriela Salvio, Natalia M Inada, Vanderlei S Bagnato, Harry Moseley
BACKGROUND: Topical photodynamic therapy (PDT) is a non-invasive light based therapy used to treat non-melanoma skin cancer (NMSC) and dysplasia. During PDT, the light sensitive molecule protoporphyrin IX (PpIX) is activated, resulting in the production of singlet oxygen, which subsequently leads to cell death. PpIX is metabolised from a topically applied pro-drug and the strong fluorescence signal associated with PpIX can be utilised as an indicator of the amount of PpIX present within the tumour tissue...
February 28, 2017: Photodiagnosis and Photodynamic Therapy
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