keyword
MENU ▼
Read by QxMD icon Read
search

Actinic keratosis

keyword
https://www.readbyqxmd.com/read/27889291/acantholytic-squamous-cell-carcinoma-is-usually-associated-with-hair-follicles-not-acantholytic-actinic-keratosis-and-is-not-high-risk-diagnosis-management-and-clinical-outcomes-in-a-series-of-115-cases
#1
Toru Ogawa, Maija Kiuru, Thomas H Konia, Maxwell A Fung
BACKGROUND: Acantholytic squamous cell carcinoma (aSCC) is regarded as a high-risk variant of cutaneous squamous cell carcinoma (SCC). Acantholytic actinic keratosis (aAK) has been regarded as a precursor risk factor for aSCC. However, supporting evidence is limited. OBJECTIVE: We sought to document clinical features, histologic features, management, and outcomes in a series of aSCC cases. METHODS: Definitions of aSCC, aAK, and aSCC arising in association with aAK were applied to a consecutive series of aSCC cases...
November 23, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27869649/randomized-trial-of-calcipotriol-combined-with-5-fluorouracil-for-skin-cancer-precursor-immunotherapy
#2
Trevor J Cunningham, Mary Tabacchi, Jean-Pierre Eliane, Sara Moradi Tuchayi, Sindhu Manivasagam, Hengameh Mirzaalian, Ahu Turkoz, Raphael Kopan, Andras Schaffer, Arturo P Saavedra, Michael Wallendorf, Lynn A Cornelius, Shadmehr Demehri
BACKGROUND: Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments. Thymic stromal lymphopoietin (TSLP) is an epithelium-derived cytokine that induces a robust antitumor immunity in barrier-defective skin. Here, we investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil (5-FU) as an immunotherapy for actinic keratosis...
November 21, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27864996/skin-microtopography-as-a-measure-of-photoaging-and-risk-of-squamous-cell-carcinoma-of-the-skin-in-a-us-population
#3
L F Kuklinski, M S Zens, A E Perry, A C Green, M R Karagas
BACKGROUND: Skin microtopography as a measure of photoaging is a non-invasive approach to measuring chronic ultraviolet radiation (UVR) exposure, and reflects the degree of dermal elastosis in populations of European descent in the subtropics. Less is known about the utility of this approach in populations at different latitudes, and whether it relates to skin cancer risk. METHODS: A population-based case-control study of 342 SCC cases and 331 age- and gender-matched controls were evaluated for histologic evidence of solar damage and severity of photoaging based on microtopography on a six-grade scale...
November 19, 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27860083/dermoscopic-monitoring-of-efficacy-of-ingenol-mebutate-in-the-treatment-of-pigmented-and-non-pigmented-basal-cell-carcinomas
#4
Laura Diluvio, Mauro Bavetta, Monia Di Prete, Augusto Orlandi, Luca Bianchi, Elena Campione
Basal cell carcinoma is the most common non-melanoma skin cancer, and its incidence continues to raise. Although surgery can be considered the mainstay of therapy, new current pharmacological options are available and focus on tumor eradication, maximizing cosmetic results, and functional capacity. Several studies have recently reported on safety and efficacy of topical ingenol mebutate gel, a derivative of the plant Euphorbia Peplus, used to treat actinic keratosis and superficial basal cell carcinoma. In our knowledge, we report for the first time the dermoscopic evaluation of outcome and monitoring of superficial pigmented and non-pigmented basal cell carcinomas in four patients treated by this novel non-ablative agent...
November 12, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27859308/resatorvid-based-pharmacological-antagonism-of-cutaneous-tlr4-blocks-uv-induced-nf-%C3%AE%C2%BAb-and-ap-1-signaling-in-keratinocytes-and-mouse-skin
#5
Jaroslav Janda, Nichole Burkett, Karen Blohm-Mangone, Vivian Huang, Clara Curiel-Lewandrowski, David S Alberts, Emanuel F Petricoin, Valerie S Calvert, Janine Einspahr, Zigang Dong, Ann M Bode, Georg T Wondrak, Sally E Dickinson
Cutaneous exposure to solar ultraviolet (UV) radiation is a major causative factor in skin carcinogenesis, and improved molecular strategies for efficacious chemoprevention of non-melanoma skin cancer (NMSC) are urgently needed. Toll-like receptor 4 (TLR4) signaling has been shown to drive skin inflammation, photoimmunosuppression and chemical carcinogenesis. Here we have examined the feasibility of genetic and pharmacological antagonism targeting cutaneous TLR4 for the suppression of UV-induced NF-κB and AP-1 signaling in keratinocytes and mouse skin...
November 10, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27853385/efficacy-of-ingenol-mebutate-gel-for-actinic-keratosis-in-patients-treated-by-thiazide-diuretics
#6
Elena Campione, Monia Di Prete, Laura Diluvio, Luca Bianchi, Augusto Orlandi
Actinic keratosis (AK) is considered as superficial squamous cell carcinoma. Chronic sun exposure plays a central role in its pathogenesis. In particular, ultraviolet B radiation causes direct damage to the DNA, producing pyrimidine dimers that suppress the protective role of p53. Other risk factors include advanced age, male sex, and fair skin type. Even some drugs used for treating blood hypertension, such as thiazide diuretics, can increase the risk of developing AK. Their photosensitizing action seems to be connected with reactive oxygen species production...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27843896/surgical-reconstruction-of-ocular-surface-tumors-using-fibrin-sealant-tissue-adhesive
#7
Aline Roseane Queiroz de Paiva, Larissa Abreu de Azevedo Fraga, Virgínia Laura Lucas Torres
PURPOSE: To evaluate the surgical outcomes of ocular surface reconstruction in corneal-conjunctival tumors using fibrin tissue adhesive. METHODS: A prospective noncomparative study was performed between May 2013 and February 2015. Patients were submitted to routine surgical procedure for corneal-conjunctival tumor excision followed by amniotic membrane graft transplantation using fibrin tissue adhesive (Evicel®, Omrix Biopharmaceuticals Ltd., Israel). Results were assessed on the 1st, 7th, 15th and 30th postoperative days to analyze subjective complaints, adhesiveness and positioning of the graft, potential complications and recurrences...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27843579/a-prospective-clinical-trial-to-assess-lapatinib-effects-on-cutaneous-squamous-cell-carcinoma-and-actinic-keratosis
#8
D Jenni, M B Karpova, B Mühleisen, J Mangana, J Dreier, J Hafner, R Dummer
BACKGROUND: Antiepidermal growth factor receptor (EGFR)-targeted therapy is widely used in many epithelial cancer types. We investigated lapatinib effects on cutaneous squamous cell carcinoma (cSCC) scheduled for resection and in coexisting precursor lesions (actinic keratosis (AK) and Bowen's disease (BD)) in a phase 2 mode of action clinical trial including a histological workup of the cSCC. PATIENTS AND METHODS: We initiated a prospective single-centre, open-label, non-controlled clinical study with translational intentions to investigate changes in size and histopathological features in cSCC after a 14-day period of neoadjuvant lapatinib therapy at a dose of 1500 mg/day prior to surgery, to quantify the impact on AK and BD in the same patient after 56 days and to evaluate the tolerability in patients with cSCC and precursor lesions...
2016: ESMO Open
https://www.readbyqxmd.com/read/27816622/electrospun-poly-l-lactide-scaffold-for-the-controlled-and-targeted-delivery-of-a-synthetically-obtained-diclofenac-prodrug-to-treat-actinic-keratosis
#9
Germano Piccirillo, Brigida Bochicchio, Antonietta Pepe, Katja Schenke-Layland, Svenja Hinderer
: Actinic Keratosis' (AKs) are small skin lesions that are related to a prolonged sun-damage, which can develop into invasive squamous cell carcinoma (SCC) when left untreated. Effective, specific and well tolerable therapies to cure AKs are still of great interest. Diclofenac (DCF) is the current gold standard for the local treatment of AKs in terms of costs, effectiveness, side effects and tolerability. In this work, an electrospun polylactic acid (PLA) scaffold loaded with a synthetic DCF prodrug was developed and characterized...
November 2, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27811637/cutaneous-horn-of-the-eyelid-in-13-cases
#10
Renelle Pointdujour-Lim, Molly R Marous, Celine E Satija, Alexzandra M Douglass, Ralph C Eagle, Jerry A Shields, Carol L Shields
INTRODUCTION: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid. OBJECTIVE: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. DESIGN: A retrospective analysis of 13 cases of cutaneous horn of the eyelid treated between 1994 and 2014 was performed. PARTICIPANTS: Thirteen patients participated in this study...
November 2, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27796187/real-world-approach-to-actinic-keratosis-management-practical-treatment-algorithm-for-office-based-dermatology
#11
Thomas Dirschka, Girish Gupta, Giuseppe Micali, Eggert Stockfleth, Nicole Basset-Séguin, Véronique Del Marmol, Reinhard Dummer, Gregor B E Jemec, Josep Malvehy, Ketty Peris, Susana Puig, Alexander J Stratigos, Iris Zalaudek, Giovanni Pellacani
Actinic keratosis (AK) is a chronic skin disease in which multiple clinical and subclinical lesions co-exist across large areas of sun-exposed skin, resulting in field cancerisation. Lesions require treatment because of their potential to transform into invasive squamous cell carcinoma. This article aims to provide office-based dermatologists and general practitioners with simple guidance on AK treatment in daily clinical practice to supplement existing evidence-based guidelines. Novel aspects of the proposed treatment algorithm include differentiating patients according to whether they have isolated scattered lesions, lesions clustered in small areas or large affected fields without reference to specific absolute numbers of lesions...
November 13, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27792794/correction-e6-and-e7-from-beta-hpv38-cooperate-with-ultraviolet-light-in-the-development-of-actinic-keratosis-like-lesions-and-squamous-cell-carcinoma-in-mice
#12
Daniele Viarisio, Karin Mueller-Decker, Ulrich Kloz, Birgit Aengeneyndt, Annette Kopp-Schneider, Hermann-Josef Gröne, Tarik Gheit, Christa Flechtenmacher, Lutz Gissmann, Massimo Tommasino
[This corrects the article DOI: 10.1371/journal.ppat.1002125.].
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27790670/adherence-to-topical-treatments-for-actinic-keratosis
#13
L A Cardwell, S R Feldman
No abstract text is available yet for this article.
November 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27785832/tumor-regrowth-and-development-of-keratinocytic-neoplasms-in-patients-under-smoothened-inhibition-in-vivo-assessment-with-reflectance-confocal-microscopy
#14
I Alarcon, P Pasquali, J Malvehy, S Puig
BACKGROUND: The regrowth of a tumor after complete clinical response and the development of keratinocytic neoplasms while patients are still undergoing continuous vismodegib have stressed the importance of the accurate monitoring to detect recurrences earlier and ensure the best possible outcome. OBJECTIVE: The objective of this study was to determine the role of reflectance confocal microscopy (RCM) in monitoring the response of locally advanced basal cell carcinoma (laBCC) to vismodegib and to discard secondary resistance...
October 27, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27785771/pharmacoeconomic-considerations-in-treating-actinic-keratosis-an-update
#15
REVIEW
Spencer M Vale, Dane Hill, Steven R Feldman
Actinic keratosis is one of the most common dermatological diagnoses worldwide, especially among the elderly, fair-skinned, and immunocompromised, and is associated with a risk of transformation to skin cancer. With actinic keratosis and skin cancer prevalence increasing as the aged population expands in the US, optimizing treatment strategies may produce cost savings for the healthcare system. Since the time of our last review in 2008, investigation of the economic considerations in treating actinic keratosis has advanced...
October 27, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27784514/survey-of-patient-satisfaction-with-ingenol-mebutate-gel-treatment-for-actinic-keratosis-from-a-community-dermatology-practice
#16
Dale Schaefer
Actinic keratosis (AK) is a condition that can present as a discrete lesion or as areas of confluent lesions. It is generally treated either with cryosurgery or, less frequently, with patient-applied topical medications or photodynamic therapy. Topical therapies can offer benefits over cryosurgery, especially in patients with significant actinic damage. The long durations of topical treatment required and the persistence of associated local skin reactions (LSRs) may deter some patients from adhering to topical therapies and thus affect clinical outcomes...
2016: Skinmed
https://www.readbyqxmd.com/read/27782094/photodynamic-therapy-and-non-melanoma-skin-cancer
#17
REVIEW
Liezel L Griffin, John T Lear
Non-melanoma skin cancer (NMSC) is the most common malignancy among the Caucasian population. Photodynamic therapy (PDT) is gaining popularity for the treatment of basal cell carcinoma (BCC), Bowen's disease (BD) and actinic keratosis (AK). A topical or systemic exogenous photosensitiser, results in selective uptake by malignant cells. Protoporphyrin IX (PpIX) is produced then activated by the introduction of a light source. Daylight-mediated MAL (methyl aminolaevulinate) PDT for AKs has the advantage of decreased pain and better patient tolerance...
October 22, 2016: Cancers
https://www.readbyqxmd.com/read/27782043/photodynamic-therapy-for-non-melanoma-skin-cancers
#18
REVIEW
Diana K Cohen, Peter K Lee
Non-melanoma skin cancer (NMSC) is traditionally treated with surgical excision. Nonsurgical methods such as cryotherapy and topical chemotherapeutics, amongst other treatments, are other options. Actinic keratosis (AKs) are considered precancerous lesions that eventually may progress to squamous cell carcinoma (SCC). Photodynamic therapy (PDT) offers an effective treatment for AKs, and is also effective for superficial basal cell carcinoma (BCC). Nodular BCC and Bowen's disease (SCC in situ) have shown acceptable response rates with PDT, although recurrence rates are higher for these two NMSC subtypes...
October 4, 2016: Cancers
https://www.readbyqxmd.com/read/27775832/the-use-of-illuminance-as-a-guide-to-effective-light-delivery-during-daylight-pdt-in-the-uk
#19
P O'Mahoney, M Khazova, M Higlett, T Lister, S Ibbotson, E Eadie
BACKGROUND: Daylight PDT (dPDT) is an effective and nearly painless treatment for field-change actinic keratosis. Measuring the protoprophyrin-IX (PpIX)-weighted exposure dose can give an indication of when conditions are most viable for effective dPDT. It would be advantageous for practitioners if more detailed information of exposure dose and appropriate treatment conditions were available. Where sophisticated measurement equipment is unavailable, simpler and more cost-effective methods of dose measurement are desirable...
October 24, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27748261/long-term-efficacy-and-safety-of-daylight-photodynamic-therapy-with-methyl-amninolevulinate-for-actinic-keratosis-of-the-face-and-scalp
#20
Maria Concetta Fargnoli, Antonella Piccioni, Luca Neri, Sara Tambone, Cristina Pellegrini, Ketty Peris
No abstract text is available yet for this article.
October 17, 2016: European Journal of Dermatology: EJD
keyword
keyword
3039
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"