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Actinic keratosis

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https://www.readbyqxmd.com/read/29765964/a-rare-syndrome-resembling-scleroderma-huriez-syndrome
#1
Nil Su Çelik, Şirin Yaşar, Sema Aytekin, Pembegül Güneş
Huriez syndrome, also referred to as "sclerotylosis," is a rare autosomal dominant genodermatosis characterized by the triad of congenital scleroatrophy of the distal extremities, palmoplantar keratoderma, and hypoplastic nails. The development of aggressive squamous cell carcinoma (SCC) arising in the scleroatrophic area is also a distinctive feature of the syndrome. Early diagnosis is important due to the early onset, mostly in the third to fourth decades of life, and aggressive progress of SCC, which occurs in around 15% of affected individuals...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29752800/raman-biophysical-markers-in-skin-cancer-diagnosis
#2
Xu Feng, Austin J Moy, Hieu T M Nguyen, Yao Zhang, Jason Zhang, Matthew C Fox, Katherine R Sebastian, Jason S Reichenberg, Mia K Markey, James W Tunnell
Raman spectroscopy (RS) has demonstrated great potential for in vivo cancer screening; however, the biophysical changes that occur for specific diagnoses remain unclear. We recently developed an inverse biophysical skin cancer model to address this issue. Here, we presented the first demonstration of in vivo melanoma and nonmelanoma skin cancer (NMSC) detection based on this model. We fit the model to our previous clinical dataset and extracted the concentration of eight Raman active components in 100 lesions in 65 patients diagnosed with malignant melanoma (MM), dysplastic nevi (DN), basal cell carcinoma, squamous cell carcinoma, and actinic keratosis...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29729152/features-of-vascular-dermatoscopic-component-in-various-morphological-types-of-epidermal-dysplasia
#3
Оlena О Оshyvalova
OBJECTIVE: Introduction: Dermatologists of many foreign countries have been successfully using and developing dermatoscopy as a method of early diagnosis of skin tumors for three decades. It is believed that the vascular dermatoscopiccomponent is a promising criterion for the diagnosis of epidermal dysplasia of the skin and can be used for differential diagnosis. The aim of the work was to study the features of the vascular dermatoscopic component in actinic keratosis (AK), non-invasive (squamous cell carcinoma in situ-SCCis) and invasive forms of squamous cell carcinoma (cSCC)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29723931/photosensitizing-antihypertensive-drug-use-and-risk-of-cutaneous-squamous-cell-carcinoma
#4
K A Su, L A Habel, N S Achacoso, G D Friedman, M M Asgari
BACKGROUND: Many antihypertensive drugs (ADs) are photosensitizing, heightening reactivity of the skin to sunlight. Photosensitizing ADs have been associated with lip cancer, but whether they impact cutaneous squamous cell carcinoma (cSCC) risk is unknown. OBJECTIVES: To examine the association between AD use and cSCC risk among a cohort of non-Hispanic whites with hypertension enrolled in a comprehensive integrated healthcare delivery system in northern California (n=28,357)...
May 3, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29704456/tretinoin-0-05-cream-versus-5-peel-for-photoaging-and-field-cancerization-of-the-forearms-randomized-evaluator-blinded-clinical-trial
#5
J M Sumita, H A Miot, J L M Soares, A C P Raminelli, S M Pereira, M M Ogawa, F R Picosse, L R S Guadanhim, M M S S Enokihara, G R Leonardi, E Bagatin
BACKGROUND: Topical tretinoin cream is the gold standard treatment for skin aging, particularly photoaging. The purpose of tretinoin peel is to obtain similar results but in a shorter time, however there have been few controlled trials on its effectiveness. OBJECTIVE: To compare efficacy and safety of tretinoin 0.05% cream and 5% as a peeling agent on photoaging and field cancerization of the forearms. METHODS: Clinical trial with therapeutic intervention, prospective, randomized (computer-generated randomization list), parallel, comparative (intrasubject) and evaluator-blinded (except for histology and immunohistochemistry), including twenty-four women (48 forearms) aged over 60 years who have not undergone hormone replacement, and categorized as Fitzpatrick skin phototype II or III...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29704211/-occupational-skin-cancer-prevention-and-recommendations-for-uv-protection-as-part-of-the-treatment-approved-by-the-public-statutory-employers-liability-insurance
#6
REVIEW
M Rocholl, M Ludewig, C Skudlik, A Wilke
In Germany, approximately 2 to 3 million employees work in outdoor professions. They are exceptionally exposed to solar ultraviolet (UV) radiation for a large part of their daily working time. Cumulative UV exposure is associated with a significantly increased risk of skin cancer for outdoor workers from various occupational groups (e. g. landscape and horticulture, agriculture and forestry, fisheries and seafaring, construction and trade, as well as sports teachers, lifeguards and mountain guides). Since 1 January 2015, squamous cell carcinoma and multiple actinic keratosis due to natural UV radiation can be recognised as occupational disease No...
April 27, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29697423/using-stratum-corneum-thickness-and-configuration-to-distinguish-lichenoid-dermatoses
#7
Amanda F Marsch
BACKGROUND: Clues in the stratum corneum (SC) can aide in histopathologic diagnosis of many conditions. OBJECTIVE: To determine if SC configuration and thickness could help differentiate the lichenoid dermatoses. METHODS: A retrospective study was performed. A total of 305 cases (55 lichenoid keratosis, 51 lichen planus, 7 hypertrophic lichen planus, 40 lichenoid drug eruption, 19 lichenoid graft-vs.-host disease, 14 hypertrophic lupus, 46 lichenoid actinic keratosis, 73 lentigo maligna) fulfilled the selection criteria...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29684690/photodynamic-therapy-with-the-use-of-superluminescent-diodes-sled-in-the-treatment-of-actinic-keratosis
#8
Joanna Bartosińska, Katarzyna Wolska, Agnieszka Gerkowicz, Marta Niewiedzioł, Małgorzata Michalska- Jakubus, Małgorzata Komza, Tomasz Klepaczewski, Mirosław Kwaśny, Dorota Krasowska
BACKGROUND: Superluminescent diodes (sLED) appear to be an innovative and promising light source in photodynamic therapy (PDT), especially in actinic keratosis (AK) lesions treatment. AIM: Assessment of tolerability and efficacy of sLED in topical 5-aminolevulinic acid (ALA) PDT of AK lesions. METHODS: 27 patients received ALA PDT with the use of sLED with "soft starter". RESULTS: Tolerability of sLED lamp depended on the treated lesions field (extension) rather than on their thickness...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29683288/lentigo-maligna-diagnosis-and-treatment
#9
Erika V De Luca, Francesca Perino, Alessandro Di Stefani, Valeria Coco, Barbara Fossati, Ketty Peris
Lentigo maligna (LM) is an in situ subtype of melanoma, clinically presenting as a pigmented, asymmetric macule that originates mostly on the head and neck and spreads slowly. The diagnosis may be challenging both for clinicians and pathologists. Dermatoscopy and reflectance confocal microscopy represent a useful tool in the differentiation of LM from other pigmented lesions, such as pigmented actinic keratosis, solar lentigines, seborrheic keratosis and lichen planus-like keratosis. Moreover, those non-invasive diagnostic technique may be crucial in the selection of optimal biopsy sites in equivocal lesions, in pre-surgical mapping and in evaluating and monitoring response to non-surgical treatments...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29682736/medical-comorbidities-in-patients-with-lichen-planopilaris-a-retrospective-case-control-study
#10
Raymond M Fertig, Shasa Hu, Austin J Maddy, Alexandra Balaban, Nouf Aleid, Adam Aldahan, Antonella Tosti
BACKGROUND: Lichen planopilaris (LPP) is a rare inflammatory lymphocyte-mediated disease of the scalp considered to have an autoimmune pathogenesis. OBJECTIVES: To identify the prevalence of medical comorbidities in patients with classic LPP (CLPP) and frontal fibrosing alopecia (FFA). METHODS: The medical records of 206 LPP patients and 323 control patients were retrospectively reviewed for existing comorbidities. The control group consisted of 257 patients with androgenetic alopecia (ICD 9 = 704...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29676831/correlations-between-histopathologic-and-dermoscopic-findings-in-korean-actinic-keratosis
#11
Dong Won Lee, Dae Yeon Kim, Ji Hyuck Hong, Soo Hong Seo, Young Chul Kye, Hyo Hyun Ahn
Skin biopsy for AK diagnosis is usually performed on only a limited part of the whole lesion. Therefore, a clinical diagnosis is important. According to a study, there is no significant correlation between histopathological and clinical classification system. We examined the correlation between microscopic information and dermoscopic findings to deduce if dermoscopic information reflects histopathologic grade severity. Forty seven patients with histologically confirmed AK were enrolled and positive ratio of red pseudonetwork, rosette, red background and targetoid signs, white-to-yellow scale, white structureless area, and pigmentation from dermoscopic findings were investigated...
April 20, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29675945/epigenetically-enhanced-pdt-epdt-induces-significantly-higher-levels-of-multiple-extrinsic-pathway-apoptotic-factors-than-standard-pdt-resulting-in-greater-extrinsic-and-overall-apoptosis-of-ctcl
#12
Katrin A Salva, Youn H Kim, Ziba Rahbar, Gary S Wood
Aminolevulinate-based photodynamic therapy (ALA-PDT) selectively eliminates diseased tissues primarily through the induction of intrinsic apoptotic pathway. ALA-PDT is a first-line therapy for actinic keratosis, however, it is less effective for cutaneous T-cell lymphoma (CTCL). We have previously demonstrated that the resistance of CTCL to apoptosis correlates with decreased expression of death receptors such as FAS, and that methotrexate functions as an epigenetic regulator that re-establishes the susceptibility of CTCL to extrinsic pathway apoptosis...
April 20, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29669340/swiss-german-version-of-the-actinic-keratosis-quality-of-life-questionnaire
#13
Larissa S Meier, Maria Schubert, Yasemin Göksu, Solveig Esmann, Gabrielle R Vinding, Gregor B E Jemec, Günther F L Hofbauer
BACKGROUND: Actinic keratosis (AK) is a sun-induced skin lesion that may progress to invasive squamous cell carcinoma of the skin. Recently, the Actinic Keratosis Quality of Life questionnaire (AKQoL) was designed for patients with AK in Denmark as a specific quality of life instrument for AK patients. OBJECTIVE: The objective of this study was to adapt the AKQoL for the German language region of Switzerland and to evaluate its psychometric properties (validity, reliability)...
April 18, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29668097/field-change-actinic-keratosis-and-immunosuppression-therapeutic-options
#14
S H Ibbotson
No abstract text is available yet for this article.
April 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29667728/comparison-of-10-efficient-protocols-for-photodynamic-therapy-of-actinic-keratosis-how-relevant-are-effective-light-dose-and-local-damage-in-predicting-the-complete-response-rate-at-3-months
#15
Anne-Sophie Vignion-Dewalle, Gregory Baert, Elise Thecua, Fabienne Lecomte, Claire Vicentini, Henry Abi-Rached, Laurent Mortier, Serge Mordon
BACKGROUND: Topical photodynamic therapy is an established treatment modality for various dermatological conditions, including actinic keratosis. In Europe, the approved protocols for photodynamic therapy of actinic keratosis involve irradiation with either an Aktilite CL 128 lamp or daylight, whereas irradiation with the Blu-U illuminator is approved in the United States. Many other protocols using irradiation by a variety of light sources are also clinically efficient. OBJECTIVES: This paper aims to compare 10 different protocols with clinically proven efficacy for photodynamic therapy of actinic keratosis and the available spectral irradiance of the light source...
April 18, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29665991/differential-proteomic-analysis-of-actinic-keratosis-bowen-s-disease-and-cutaneous-squamous-cell-carcinoma-by-label-free-lc-ms-ms
#16
Ali Azimi, Kimberley L Kaufman, Marina Ali, Jonathan Arthur, Steven Kossard, Pablo Fernandez-Penas
BACKGROUND: The boundaries between actinic keratosis (AK), Bowen's disease (BD), and cutaneous squamous cell carcinoma (cSCC) are sometimes not clear. Large-scale proteomic profiling studies of these lesions are also non-existent. OBJECTIVE: To evaluate proteomic changes between normal epidermis, AK, BD and cSCC that could support a molecular classification and improve our understanding of disease progression. METHODS: Microdissected formalin-fixed paraffin embedded samples of normal epidermis (n = 4, pooled), AK (n = 10), BD (n = 10) and cSCC (n = 10) were analyzed by mass spectrometry...
April 10, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29663426/comparison-of-blue-and-white-lamp-light-with-sunlight-for-daylight-mediated-5-ala-photodynamic-therapy-in-vivo
#17
Kayla Marra, Ethan P LaRochelle, M Shane Chapman, P Jack Hoopes, Karina Lukovits, Edward V Maytin, Tayyaba Hasan, Brian W Pogue
Daylight-mediated photodynamic therapy (d-PDT) as a treatment for actinic keratosis (AK) is an increasingly common technique due to a significant reduction in pain, leading to better patient tolerability. While past studies have looked at different light sources and delivery methods, this study strives to provide equivalent PpIX-weighted light doses with the hypothesis that artificial light sources could be equally as effective as natural sunlight if their PpIX-weighted fluences were equalized. Normal mouse skin was used as the model to compare blue LED light, metal halide white light, and natural sunlight, with minimal incubation time between topical ALA application and the onset of light delivery...
April 16, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29620004/a-new-dermoscopic-algorithm-for-the-differential-diagnosis-of-facial-lentigo-maligna-and-pigmented-actinic-keratosis
#18
Tamara Micantonio, Luca Neri, Caterina Longo, Simone Grassi, Alessandro Di Stefani, Ambra Antonini, Valeria Coco, Maria Concetta Fargnoli, Giuseppe Argenziano, Ketty Peris
The clinical and dermoscopic diagnosis of facial lentigo maligna (LM) and pigmented actinic keratosis (PAK) remains challenging, particularly at the early disease stages. To identify dermoscopic criteria that might be useful to differentiate LM from PAK, and to elaborate and validate an automated diagnostic algorithm for facial LM/PAK. We performed a retrospective multicentre study to evaluate dermoscopic images of histologically-proven LM and PAK, and assess previously described dermoscopic criteria. In the first part of the study, 61 cases of LM and 74 PAK were examined and a parsimonious algorithm was elaborated using stepwise discriminant analysis...
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29619263/a-rare-presentation-of-actinic-keratosis-affecting-the-tarsal-conjunctiva-and-review-of-the-literature
#19
Selina Khan, Melanie Chak
We report an unusual case of actinic keratosis (AK) of the tarsal conjunctiva in a 63-year-old man. Examination revealed a crusty, leukoplakic lesion prone to bleeding on the tarsal conjunctiva of the right upper eyelid. This was treated by surgical excisional biopsy. At 1-year follow-up, there was no evidence of recurrence and the surgical site was completely healed without conjunctival scarring. Current opinion cites excessive exposure to ultraviolet (UV) radiation, in particular UV-B in sunlight, as the causative agent in developing AK...
2018: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29617135/discovery-of-novel-dual-mechanism-of-action-src-signaling-and-tubulin-polymerization-inhibitors-kx2-391-and-kx2-361
#20
Michael P Smolinski, Yahao Bu, James Clements, Irwin H Gelman, Taher Hegab, David L Cutler, Jane W S Fang, Gerald Fetterly, Rudolf Kwan, Allen Barnett, Johnson Y N Lau, David G Hangauer
The discovery of potent, peptide site directed, tyrosine kinase inhibitors has remained an elusive goal. Herein we describe the discovery of two such clinical candidates that inhibit the tyrosine kinase Src. Compound 1 is a phase 3 clinical trial candidate that is likely to provide a first in class topical treatment for actinic keratosis (AK) with good efficacy and dramatically less toxicity compared to existing standard therapy. Compound 2 is a phase 1 clinical trial candidate that is likely to provide a first in class treatment of malignant glioblastoma and induces 30% long term complete tumor remission in animal models...
April 4, 2018: Journal of Medicinal Chemistry
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