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https://www.readbyqxmd.com/read/29678491/polycystic-ovary-syndrome-pcos-an-inflammatory-systemic-lifestyle-endocrinopathy
#1
REVIEW
Seema Patel
Polycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, apart from a gamut of other metabolic co-morbidities such as insulin resistance, obesity, cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the affected females...
April 17, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29678285/pharmacogenetics-of-g-protein-coupled-receptors-variants-fsh-receptor-and-infertility-treatment
#2
REVIEW
Daniele Santi, Francesco Potì, Manuela Simoni, Livio Casarini
Infertility treatment may represent a paradigmatic example of precision medicine. Follicle-stimulating hormone (FSH) has been proposed as a valuable therapeutic option both in males and in females, even if a standardized approach is far to be established. To date, several genetic mutations as well as polymorphisms have been demonstrated to significantly affect the pathophysiology of FSH-FSH receptor (FSHR) interaction, although the underlying molecular mechanisms remain unclear. This review aims to highlight possible aspects of FSH therapy that could benefit from a pharmacogenetic approach, providing an up-to-date overview of the variability of the response to FSH treatment in both sexes...
April 2018: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29675489/female-genital-tuberculosis-cases-with-distinct-clinical-symptoms-four-case-reports
#3
Gonul Aslan, Mahmut Ulger, Seda Tezcan Ulger, Huseyin Durukan, Faik Gurkan Yazici, Gurol Emekdas
Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Genital TB (GTB) is a form of extrapulmonary TB that occurs more frequently in women, in whom it classically presents in association with menstrual irregularity, pregnancy loss and short and long-term sequelae especially infertility in infected women. Patients with GTB are usually young women diagnosed during workup for infertility. GTB is rare in postmenopausal women and responsible for only approximately 1% of postmenopausal bleeding...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29673000/effect-of-insemination-timing-on-pregnancy-outcome-in-association-with-female-age-sperm-motility-sperm-morphology-and-sperm-concentration-in-intrauterine-insemination
#4
Jisun Lee, Suna Hwang, Jaehun Lee, Junghyun Yoo, Dongmin Jang, Kyungjoo Hwang, Miran Kim
AIM: We investigated the effect of insemination timing on pregnancy outcomes in intrauterine insemination (IUI) cycles. METHODS: This is a retrospective study of 411 IUI cycles performed with a diagnosis of unexplained infertility and male factor infertility. The cycles were divided according to the interval between insemination and ovulation: ≤36 h, 36-37 h, 37-38 h and >38 h. The overall pregnancy rate, chemical pregnancy rate and clinical pregnancy rate were compared...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29671678/chronological-age-vs-biological-age-a-retrospective-analysis-on-age-specific-serum-anti-m%C3%A3-llerian-hormone-levels-for-3280-females-in-reproductive-center-clinic
#5
Jieru Zhu, Tao Li, Weijie Xing, Hui Lin, Jianping Ou
The aim of the present study was to determine the correlation between chronological age and biological age by characterizing age-specific serum anti-Müllerian hormone (AMH) values for 3280 Chinese women. A retrospective analysis including 3280 females between 10 to 52 years old was conducted from January 2016 to December 2016 in the clinical laboratory of Center for Reproductive Medicine, The Third Affiliated Hospital of Sun Yat-sen University, China. All included women were divided into several groups by age...
April 19, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29671363/mutation-analysis-of-the-tubb8-gene-in-primary-infertile-women-with-arrest-in-oocyte-maturation
#6
An-Cong Wang, Yu-Song Zhang, Bao-Song Wang, Xiang-Yu Zhao, Feng-Xia Wu, Xiang-Hong Zhai, Ju-Xiang Sun, Shi-Yue Mei
Tubulin beta eight class VIII (TUBB8) is a subtype of β-tubulin that only exists in primates. Mutations in the TUBB8 gene have been proven to cause oocyte maturation arrest. The aim of this study was to identify the new types of mutations in TUBB8. Six women (families) with oocyte maturation arrest and 100 healthy controls were recruited. The sequence of the TUBB8 gene was amplified and analyzed by Sanger sequencing, which revealed a de novo heterozygous variant c.292G > A (p.G98R) of TUBB8 in one affected individual...
April 19, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29670898/effects-of-withania-somnifera-on-reproductive-system-a-systematic-review-of-the-available-evidence
#7
REVIEW
Ramin Nasimi Doost Azgomi, Afshar Zomorrodi, Hossein Nazemyieh, Seyed Mohammad Bagher Fazljou, Homayoun Sadeghi Bazargani, Fatemeh Nejatbakhsh, Arezoo Moini Jazani, Yadollah Ahmadi AsrBadr
Introduction: Withania somnifera (WS) also known as ashwagandha is a well-known medicinal plant used in traditional medicine in many countries for infertility treatment. The present study was aimed at systemically reviewing therapeutic effects of WS on the reproductive system. Methods: This systematic review study was designed in 2016. Required data were obtained from PubMed, Scopus, Google Scholar, Cochrane Library, Science Direct, Web of Knowledge, Web of Science, and manual search of articles, grey literature, reference checking, and expert contact...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29670782/endometriosis-in-a-man-as-a-rare-source-of-abdominal-pain-a-case-report-and-review-of-the-literature
#8
Christina Rei, Thomas Williams, Michael Feloney
Endometriosis occurs when a tissue resembling endometrial glands and stroma grows in ectopic sites, commonly causing infertility and pain. This condition is most often seen in women of reproductive age, involving pelvic sites such as the ovaries, broad ligaments, uterosacral ligaments, and posterior cul-de-sac. Very rarely, endometriosis has also been found in the lower genitourinary tract of men. A 40-year-old man presented to his primary care physician with abdominal pain. Further imaging discovered a midline mass...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29670338/preference-for-anonymity-in-sperm-donation-for-artificial-insemination-an-experience-from-low-resource-settings-in-nigeria
#9
Euzebus Chinonye Ezugwu, George U Eleje, Chukwuemeka A Iyoke, Sunday G Mba, Henry C Nnaji, Chukwunonso I Enechukwu, Peter O Nkwo
Objective: Anonymous sperm donation is a common practice in Nigeria with its associated legal and ethical challenges. This study aimed to investigate infertile couples' opinions about issues of sperm donor anonymity and to determine factors that might influence their preferences. Methods: A cross-sectional, multicentered, questionnaire-based study was conducted among infertile couples attending infertility clinics in three tertiary hospitals in the south-eastern region of Nigeria over a period of 6 months...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29668891/maternal-polycystic-ovarian-syndrome-and-early-offspring-development
#10
Griffith A Bell, Rajeshwari Sundaram, Sunni L Mumford, Hyojun Park, James Mills, Erin M Bell, Miranda Broadney, Edwina H Yeung
STUDY QUESTION: Is maternal polycystic ovarian syndrome (PCOS) associated with developmental delays in offspring? SUMMARY ANSWER: Offspring of mothers with PCOS were at higher risk of failure on the Ages and Stages Questionnaire (ASQ). WHAT IS KNOWN ALREADY: There is growing evidence that offspring of mothers with PCOS may be at higher risk for developmental disorders due to potential exposure to hyperandrogenism and insulin resistance. Few studies exist regarding maternal PCOS and early childhood development in the USA...
April 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29662824/knowledge-regarding-factors-that-influence-fertility-in-thai-reproductive-age-population-living-in-urban-area-a-cross-sectional-study
#11
Sarapan Na Nakhon, Pawan Limvorapitux, Patsama Vichinsartvichai
Objective: To survey knowledge about the factors that influence fertility in a reproductive-age population living in an urban area. Methods: A cross-sectional study was conducted using a questionnaire-based survey among both males and females aged 18-45 years living in the Bangkok metropolitan area. Results: The mean age of the participants was 26.8±7.2 years (male, 41.9%; female, 58.1%). Of the participants, 53.1% had an undergraduate degree and 57...
March 2018: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29662716/social-stigma-and-familial-attitudes-related-to-infertility
#12
Rahime Nida Ergin, Aslıhan Polat, Bülent Kars, Deniz Öztekin, Kenan Sofuoğlu, Eray Çalışkan
Objective: To determine the perceived social stigma and familial attitides and perception of sexuality in infertile couples attending infertility clinics. Materials and Methods: Infertile couples attending infertility clinics between the years of 2014 and 2015 were requested to complete detailed evaluation forms including questions related to the social stigma on their infertility, their familial attitudes, and perception of sexuality. Any partner of the infertile couple accepting to enroll in the study was given the evaluation forms...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29661259/low-fertility-fecundity-and-numbers-of-mated-female-offspring-explain-the-lower-reproductive-success-of-the-parasitic-mite-varroa-destructor-in-african-honeybees
#13
Beatrice T Nganso, Ayuka T Fombong, Abdullahi A Yusuf, Christian W W Pirk, Charles Stuhl, Baldwyn Torto
Although Varroa destructor is the most serious ecto-parasite to the honeybee, Apis mellifera L., some honeybee populations such as Apis mellifera scutellata in Kenya can survive mite infestations without treatment. Previously, we reported that grooming behaviour could be a potential tolerant mechanism expressed by this honeybee subspecies towards mite infestation. However, both hygienic and grooming behaviours could not explain the lower mite-infestation levels recorded in these colonies. Here, we investigated the involvement of other potential resistant mechanisms including suppression of mite reproduction in worker brood cells of A...
April 17, 2018: Parasitology
https://www.readbyqxmd.com/read/29652724/complexities-and-potential-pitfalls-of-clinical-study-design-and-data-analysis-in-assisted-reproduction
#14
George Patounakis, Micah J Hill
PURPOSE OF REVIEW: The purpose of the current review is to describe the common pitfalls in design and statistical analysis of reproductive medicine studies. It serves to guide both authors and reviewers toward reducing the incidence of spurious statistical results and erroneous conclusions. RECENT FINDINGS: The large amount of data gathered in IVF cycles leads to problems with multiplicity, multicollinearity, and over fitting of regression models. Furthermore, the use of the word 'trend' to describe nonsignificant results has increased in recent years...
April 12, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29648485/biochemical-hematological-and-hormonal-profile-of-rats-orally-administered-methanol-stem-bark-extract-of-napoleona-vogelii-hook-and-planch-lecythidaceae
#15
Victor Olabowale Ikumawoyi, Esther Oluwatoyin Agbaje, Olufunsho Awodele, Akinwumi Akinyinka Akinyede
Napoleona vogelii is used in traditional medicine for the management of stomach aches, ulcer, and cancers. This study was conducted to investigate the subchronic toxicological effect of methanol stem bark extract of N. vogelii on biochemical, hematological, and hormonal profile of male and female rats. Forty rats of both sexes were randomly divided into four groups of 10 rats each and were administered 100, 200, and 400 mg/kg of the extract p.o. for 90 d. Ten milliliter per kilogram of distilled water p...
April 12, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29644330/pregnancy-complications-in-infertile-patients-with-polycystic-ovary-syndrome-updated-evidences
#16
Stefano Palomba, Angela Falbo, Jessica Daolio, Francesco A Battaglia, Giovanni B LA Sala
Polycystic ovary syndrome (PCOS) is a common female disorder with a pathogenesis still today not completely known. To the present, PCOS is considered more than just a reproductive disorder since several metabolic consequences that could affect women's health during different stages of reproductive and post-reproductive life were reported. The aim of the current review was to evaluate present evidence-based data regarding the pregnancy complications in infertile patients with PCOS. An extensive literature search until February 2018 was performed in PubMed, Medline, the Cochrane Library and Web of Science...
April 11, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29642908/putative-human-sperm-interactome-a-networks-study
#17
Alessandra Ordinelli, Nicola Bernabò, Massimiliano Orsini, Mauro Mattioli, Barbara Barboni
BACKGROUND: For over sixty years, it has been known that mammalian spermatozoa immediately after ejaculation are virtually infertile. They became able to fertilize only after they reside for long time (hours to days) within female genital tract where they complete their functional maturation, the capacitation. This process is finely regulated by the interaction with the female environment and involves, in spermatozoa, a myriad of molecules as messengers and target of signals. Since, to date, a model able to represent the molecular interaction that characterize sperm physiology does not exist, we realized the Human Sperm Interactme Network3...
April 11, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29642802/effect-of-high-fat-diet-on-immature-female-mice-and-messenger-and-noncoding-rna-expression-profiling-in-ovary-and-white-adipose-tissue
#18
Bin-Bin Huang, Xiao-Chun Liu, Xiao-Yun Qin, Jie Chen, Pei-Gen Ren, Wei-Fen Deng, Jian Zhang
Obesity is a chronic multifactorial disease prevalent in many areas of the world and is a major cause of morbidity and mortality. In women, obesity increases the risks of both metabolic and reproductive diseases, such as diabetes and infertility. The mechanisms underlying these effects, especially in young women, are largely unknown. To explore these mechanisms, we established a high-fat diet (HFD) model of obesity in immature female mice. Microarray analysis of gene expression in ovaries and white adipose tissue identified a large number of differentially expressed genes (>1...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29630096/effects-of-testosterone-on-ppar%C3%AE-and-p450arom-expression-in-polycystic-ovary-syndrome-patients-and-related-mechanisms
#19
Y He, C-L Wang
OBJECTIVE: Polycystic ovary syndrome (PCOS) causes ovulation disorder and infertility in female patients. This study recruited PCOS patients and adopted testosterone therapy to analyze its effect on expression of nuclear peroxisome proliferation activated receptor γ (PPARγ), and cytochrome P450 aromatase (P450arom) in ovary granular cells of patients. PATIENTS AND METHODS: PCOS and non-PCOS patients were treated with testosterone at 1.0 nmol/L, 10 nmol/L. qRT-PCR was used to detect the expressions of PPARγ and P450arom while Western blot was performed for the evaluation of protein expression...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29628616/updates-on-uterine-artery-embolization
#20
REVIEW
Maureen P Kohi, James B Spies
Uterine fibroids (leiomyomas) are the most common benign neoplasm of the female pelvis and have a lifetime prevalence exceeding 80% among African American women and approaching 70% among Caucasian women. Approximately 50% of women with fibroids experience symptoms which may include menorrhagia that may result in anemia, bulk symptoms with bladder and bowel dysfunction and abdominal protrusion, dysmenorrhea, and infertility. Hysterectomy remains the most common treatment option for fibroids and concerns have been raised about the overuse of this procedure...
March 2018: Seminars in Interventional Radiology
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