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NF-kB and exercise

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https://www.readbyqxmd.com/read/29137729/the-shear-wave-elastic-modulus-and-the-increased-nuclear-factor-kappa-b-nf-kb-p65-and-cyclooxygenase-2-cox-2-expression-in-the-area-of-myofascial-trigger-points-activated-in-a-rat-model-by-blunt-trauma-to-the-vastus-medialis
#1
Hengyong Lv, Zhen Li, Tiantian Hu, Yuexiang Wang, Jinpeng Wu, Yingxin Li
We aimed to elucidate the increased inflammatory cytokines expression such as nuclear factor kappa B (NF-kB/p65), cyclooxygenase-2 (COX-2), and voltage-gated calcium channels (VGCC) in the area of activated myofascial trigger points (MTrPs) in a rat model by blunt trauma to the vastus medialis and to evaluate the feasibility of a quantitative analysis of muscle elastic modulus using shear wave elastography (SWE). Twelve 7-week-old male SD rats were divided into normal (NM, n = 6) and model groups (MO, n = 6)...
November 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28858844/can-regular-moderate-exercise-lead-to-changes-in-mirna-146a-and-its-adapter-proteins-in-the-kidney-of-streptozotocin-induced-diabetic-male-rats
#2
H Oghbaei, N Ahmadi Asl, F Sheikhzadeh
OBJECTIVE: The aim of this study was to assess whether microRNA-146a and its adapter proteins TNF receptor associated factor6 (TRAF6) and interleukin-1 receptor-associated kinase-1 (IRAK1) may be changed in the kidney of streptozotocin-induced diabetic rats, following regular moderate exercise. METHODS: Forty adult male Wistar rats were allocated randomly into four groups (n=10), including sedentary control (SC), sedentary diabetic (SD), healthy sixty-day exercise (H60E), and diabetic sixty-day exercise (D60E) groups...
July 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28819266/amalaki-rasayana-a-traditional-indian-drug-enhances-cardiac-mitochondrial-and-contractile-functions-and-improves-cardiac-function-in-rats-with-hypertrophy
#3
Vikas Kumar, Kumar A Aneesh, K Kshemada, Kumar G S Ajith, Raj S S Binil, Neha Deora, G Sanjay, A Jaleel, T S Muraleedharan, E M Anandan, R S Mony, M S Valiathan, Kumar T R Santhosh, C C Kartha
We evaluated the cardioprotective effect of Amalaki Rasayana (AR), a rejuvenating Ayurvedic drug prepared from Phyllanthus emblica fruits in the reversal of remodeling changes in pressure overload left ventricular cardiac hypertrophy (LVH) and age-associated cardiac dysfunction in male Wistar rats. Six groups (aging groups) of 3 months old animals were given either AR or ghee and honey (GH) orally; seventh group was untreated. Ascending aorta was constricted using titanium clips in 3 months old rats (N = 24; AC groups) and after 6 months, AR or GH was given for further 12 months to two groups; one group was untreated...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28462401/effects-of-exercise-prior-or-during-pregnancy-in-high-fat-diet-fed-mice-alter-bone-gene-expression-of-female-offspring-an-experimental-study
#4
Abbasali Gaeini, Mohamadreza Baghaban Eslaminejad, Siroos Choobineh, Neda Mousavi, Sadegh Satarifard, Leila Shafieineek
BACKGROUND: Based on different studies it was shown that exercise training is an important factor in preconception and prenatal care. OBJECTIVE: The aim of this study was to determine whether regular preconception exercise training with or without exercise training during pregnancy decreases detrimental effects of maternal high fat diet on female offspring bone health. MATERIALS AND METHODS: Twenty-four C57BL/6 female mice were fed high-fat diet (35%) and were randomly divided into four groups: trained in preconception period and exercised during pregnancy (TE); trained in preconception periods but unexercised during pregnancy (TC); untrained in preconception periods but exercised during pregnancy (CE); untrained and unexercised (CC)...
February 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28326005/bioactivity-of-food-peptides-biological-response-of-rats-to-bovine-milk-whey-peptides-following-acute-exercise
#5
Carolina Soares Moura, Pablo Christiano Barboza Lollo, Priscila Neder Morato, Eder Muller Risso, Jaime Amaya-Farfan
Background: Several physiologically beneficial effects of consuming a whey protein hydrolysate (WPH) have been attributed to the greater availability of bioactive peptides. Aims: The aim was to investigate the effect of four branched-chain amino acid- (BCAA-)containing dipeptides, present in WPH, on immune modulation, stimulation of HSP expression, muscle protein synthesis, glycogen content, satiety signals and the impact of these peptides on the plasma free amino acid profiles. Methods: The animals were divided in groups: control (rest, without gavage), vehicle (water), L-isoleucyl-L-leucine (lle-Leu), L-leucyl-L-isoleucine (Leu-lle), L-valyl-Lleucine (Val-Leu), L-leucyl-L-valine (Leu-Val) and WPH...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/27739595/3-hydroxybutyrate-regulates-energy-metabolism-and-induces-bdnf-expression-in-cerebral-cortical-neurons
#6
Krisztina Marosi, Sang Woo Kim, Keelin Moehl, Morten Scheibye-Knudsen, Aiwu Cheng, Roy Cutler, Simonetta Camandola, Mark P Mattson
During fasting and vigorous exercise, a shift of brain cell energy substrate utilization from glucose to the ketone 3-hydroxybutyrate (3OHB) occurs. Studies have shown that 3OHB can protect neurons against excitotoxicity and oxidative stress, but the underlying mechanisms remain unclear. Neurons maintained in the presence of 3OHB exhibited increased oxygen consumption and ATP production, and an elevated NAD(+) /NADH ratio. We found that 3OHB metabolism increases mitochondrial respiration which drives changes in expression of brain-derived neurotrophic factor (BDNF) in cultured cerebral cortical neurons...
December 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27576008/mild-aerobic-exercise-training-hardly-affects-the-diaphragm-of-mdx-mice
#7
Giuseppe Morici, Monica Frinchi, Alessandro Pitruzzella, Valentina Di Liberto, Rosario Barone, Andrea Pace, Valentina Di Felice, Natale Belluardo, Francesco Cappello, Giuseppa Mudò, Maria R Bonsignore
In the mdx mice model of Duchenne Muscular Dystrophy (DMD), mild endurance exercise training positively affected limb skeletal muscles, whereas few and controversial data exist on the effects of training on the diaphragm. The diaphragm was examined in mdx (C57BL/10ScSn-Dmdmdx) and wild-type (WT, C57BL/10ScSc) mice under sedentary conditions (mdx-SD, WT-SD) and during mild exercise training (mdx-EX, WT-EX). At baseline, and after 30 and 45 days (training: 5 d/wk for 6 weeks), diaphragm muscle morphology and Cx39 protein were assessed...
August 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27034684/spontaneous-physical-activity-downregulates-pax7-in-cancer-cachexia
#8
Dario Coletti, Paola Aulino, Eva Pigna, Fabio Barteri, Viviana Moresi, Daniela Annibali, Sergio Adamo, Emanuele Berardi
Emerging evidence suggests that the muscle microenvironment plays a prominent role in cancer cachexia. We recently showed that NF-kB-induced Pax7 overexpression impairs the myogenic potential of muscle precursors in cachectic mice, suggesting that lowering Pax7 expression may be beneficial in cancer cachexia. We evaluated the muscle regenerative potential after acute injury in C26 colon carcinoma tumor-bearing mice and healthy controls. Our analyses confirmed that the delayed muscle regeneration observed in muscles form tumor-bearing mice was associated with a persistent local inflammation and Pax7 overexpression...
2016: Stem Cells International
https://www.readbyqxmd.com/read/26930420/assessment-of-resveratrol-apocynin-and-taurine-on-mechanical-metabolic-uncoupling-and-oxidative-stress-in-a-mouse-model-of-duchenne-muscular-dystrophy-a-comparison-with-the-gold-standard-%C3%AE-methyl-prednisolone
#9
COMPARATIVE STUDY
Roberta Francesca Capogrosso, Anna Cozzoli, Paola Mantuano, Giulia Maria Camerino, Ada Maria Massari, Valeriana Teresa Sblendorio, Michela De Bellis, Roberto Tamma, Arcangela Giustino, Beatrice Nico, Monica Montagnani, Annamaria De Luca
Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of the amino acid taurine, in comparison with the gold standard α-methyl prednisolone (PDN). The rationale was to target the overproduction of reactive oxygen species (ROS) via disease-related pathways that are worsened by mechanical-metabolic impairment such as inflammation and over-activity of NADPH oxidase (NOX) (taurine and apocynin, respectively) or the failing ROS detoxification mechanisms via sirtuin-1 (SIRT1)-peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) (resveratrol)...
April 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/26300395/effects-of-exercise-training-together-with-tamoxifen-in-reducing-mammary-tumor-burden-in-mice-possible-underlying-pathway-of-mir-21
#10
Vahid Khori, Sadegh Amani Shalamzari, Amin Isanejad, Ali Mohammad Alizadeh, Shaban Alizadeh, Saeed Khodayari, Hamid Khodayari, Shirin Shahbazi, Ali Zahedi, Hamid Sohanaki, Mahmood Khaniki, Reza Mahdian, Mojtaba Saffari, Raja Fayad
Exercise training has an anti-tumor effect and can reduce tumor growth; however, the exact underlying mechanisms of its protective effects are still obscure. MicroRNA (miR)-21 is a predictor in cancer survival, and has a potential use as an indicator of therapeutic outcome in breast malignancies. Forty-eight female BALB/c mice were equally divided into six groups to investigate the effects of interval exercise training with tamoxifen on miR-21 expression and its possible assumed mechanisms in an estrogen receptor-positive breast cancer model...
October 15, 2015: European Journal of Pharmacology
https://www.readbyqxmd.com/read/25837301/l-alanylglutamine-inhibits-signaling-proteins-that-activate-protein-degradation-but-does-not-affect-proteins-that-activate-protein-synthesis-after-an-acute-resistance-exercise
#11
Wanyi Wang, Ran Hee Choi, Geoffrey J Solares, Hung-Min Tseng, Zhenping Ding, Kyoungrae Kim, John L Ivy
Sustamine™ (SUS) is a dipeptide composed of alanine and glutamine (AlaGln). Glutamine has been suggested to increase muscle protein accretion; however, the underlying molecular mechanisms of glutamine on muscle protein metabolism following resistance exercise have not been fully addressed. In the present study, 2-month-old rats climbed a ladder 10 times with a weight equal to 75 % of their body mass attached at the tail. Rats were then orally administered one of four solutions: placebo (PLA-glycine = 0...
July 2015: Amino Acids
https://www.readbyqxmd.com/read/25566459/the-effect-of-treadmill-exercise-on-inflammatory-responses-in-rat-model-of-streptozotocin-induced-experimental-dementia-of-alzheimer-s-type
#12
Dong Hun Choi, In Su Kwon, Jung Hoon Koo, Yong Chul Jang, Eun Bum Kang, Jung Eun Byun, Hyun Sub Um, Hoo Seong Park, Dong Cheol Yeom, In Ho Cho, Joon Yong Cho
PURPOSE: The aim of this study was to investigate the effect of treadmill exercise on inflammatory response in streptozotocin (STZ)-induced animal model of Alzheimer's disease (AD). METHODS: To induce the animal model of AD, Sprague-Dawley rats were injected into intracerebroventricular (ICV) injection with 1.5 mg/kg of STZ. Rats were divided into three groups as Sham-con group (n = 7), STZ-con group (n = 7) and STZ-exe group (n = 7). Exercise group ran on the treadmill for 30 min/day, 5 days/week during 6 weeks...
June 2014: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/25539480/effect-of-training-intensity-on-nonalcoholic-fatty-liver-disease
#13
Jinkyung Cho, Shinuk Kim, Shinho Lee, Hyunsik Kang
BACKGROUND: Training intensity may play a key role in magnifying the protective effect of physical exercise against nonalcoholic fatty liver disease (NAFLD). PURPOSE: This study aimed to test the hypothesis that vigorous-intensity and interval training is as effective as moderate-intensity and continuous exercise training on NAFLD in high-fat diet (HFD)-induced obese mice. METHODS: C57BL/6 mice (N = 40) were fed a standard-chow diet (n = 10) or HFD (n = 30) for 16 wk...
August 2015: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/24944773/anti-inflammation-effect-of-exercise-and-korean-red-ginseng-in-aging-model-rats-with-diet-induced-atherosclerosis
#14
Jin Lee, Joon-Yong Cho, Won-Kyu Kim
BACKGROUND/OBJECTIVES: The aim of this study was to investigate the effects of exercise (EX) and Korean red ginseng (KRG) on inflammation mechanism in aging model rats with diet-induced atherosclerosis. MATERIALS/METHODS: Forty-eight male Sprague-Dawley rats were divided into 6 groups: Young control (Y-C), Aging control (A-C), A-C with HFD (AHF), AHF with EX (AHF-EX), AHF-EX with KRG (AHF-EX+RG), and AHF with KRG (AHF-RG). Aging was induced by D-gal (100mg/kg) and atherosclerosis was induced by HFD (60% fat) for 9 weeks...
June 2014: Nutrition Research and Practice
https://www.readbyqxmd.com/read/24258470/exercise-deactivates-leukocytes-in-asthma
#15
R P Vieira, R A Silva, M C Oliveira-Junior, F R Greiffo, A P Ligeiro-Oliveira, M A Martins, C R F Carvalho
Leukocytes play a central role in asthma physiopathology. Aerobic training (AT) reduces leukocytes recruitment to the airways, but the effects of AT on some aspects of leukocytes activation in asthma are unknown. Therefore, the effects of 4 weeks of AT on airway inflammation, pulmonary and systemic Th2 cytokines levels, leukocytes expression of pro and anti-inflammatory, pro-fibrotic, oxidants and anti-oxidants mediators in an experimental model of asthma was investigated. AT reduced the levels of IL-4, IL-5, IL-13 in bronchoalveolar lavage fluid (BALF) (p<0...
June 2014: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/23560674/creatine-supplementation-does-not-decrease-oxidative-stress-and-inflammation-in-skeletal-muscle-after-eccentric-exercise
#16
Luciano A Silva, Camila B Tromm, Guilherme Da Rosa, Karoliny Bom, Thais F Luciano, Talita Tuon, Cláudio T De Souza, Ricardo A Pinho
Thirty-six male rats were used; divided into 6 groups (n = 6): saline; creatine (Cr); eccentric exercise (EE) plus saline 24 h (saline + 24 h); eccentric exercise plus Cr 24 h (Cr + 24 h); eccentric exercise plus saline 48 h (saline + 48 h); and eccentric exercise plus Cr 48 h (Cr + 48 h). Cr supplementation was administered as a solution of 300 mg · kg body weight(-1) · day(-1) in 1 mL water, for two weeks, before the eccentric exercise. The animals were submitted to one downhill run session at 1.0 km · h(-1) until exhaustion...
2013: Journal of Sports Sciences
https://www.readbyqxmd.com/read/23559285/-effect-of-an-acute-exercise-bout-on-toll-like-receptor-4-and-inflammatory-mechanisms-in-rat-heart
#17
Carlos Cristi-Montero, Pilar Sánchez-Collado, Christiano Veneroso, María José Cuevas, Javier González-Gallego
BACKGROUND: Toll like receptor 4 (TLR-4) is a protein located in the cell membrane with an important function in the immune response of the organism. Its activation decreases heart contractility and activates nuclear transcription factor kappa B (NF-kB ). This in turn, increases the synthesis of different pro-inflammatory cytokines and the inducible enzyme nitric oxide (iNOS), which plays an important role in the inflammatory processes when nitric oxide production is enhanced. AIM: To determine if, after one session of acute exercise, expression of TLR-4 and iNOS, and activation of NF-kB are induced in rat cardiac tissue...
October 2012: Revista Médica de Chile
https://www.readbyqxmd.com/read/23357282/treadmill-exercise-induces-age-related-changes-in-aversive-memory-neuroinflammatory-and-epigenetic-processes-in-the-rat-hippocampus
#18
Gisele Agustini Lovatel, Viviane Rostirola Elsner, Karine Bertoldi, Cláudia Vanzella, Felipe Dos Santos Moysés, Adriana Vizuete, Christiano Spindler, Laura Reck Cechinel, Carlos Alexandre Netto, Alysson Renato Muotri, Ionara Rodrigues Siqueira
It has been described that exercise can modulate both inflammatory response and epigenetic modifications, although the effect of exercise on these parameters during the normal brain aging process yet remains poorly understood. Here, we investigated the effect of aging and treadmill exercise on inflammatory and epigenetic parameters specifically pro and anti-inflammatory cytokines levels, activation of NF-kB and histone H4 acetylation levels in hippocampus from Wistar rats. Additionally, we evaluated aversive memory through inhibitory avoidance task...
March 2013: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/22876724/il-17-neutrophil-activation-and-muscle-damage-following-endurance-exercise
#19
Kaoru Sugama, Katsuhiko Suzuki, Kayo Yoshitani, Koso Shiraishi, Takashi Kometani
The T-cell subset Th17 is induced partly by interleukin (IL)-6 and activated by IL-23, and produces a proinflammatory cytokine IL-17. Since IL-6 increases dramatically following long-lasting endurance exercise, this response may also stimulate the induction of IL-17 and IL-23 after exercise. The aim of this study was to clarify the dynamics of IL-17 in association with endurance exercise-induced muscle damage and inflammatory responses. Fourteen male triathletes participated in a duathlon race consisting of 5 km of running, 40 km of cycling and 5 km of running...
2012: Exercise Immunology Review
https://www.readbyqxmd.com/read/21519639/plasma-cytokine-response-lipid-peroxidation-and-nf-kb-activation-in-skeletal-muscle-following-maximum-progressive-swimming
#20
L S Cleto, A F Oleto, L P Sousa, T O Barreto, J S Cruz, C L Penaforte, J C Magalhães, J Sousa-Franco, K M C Pinto, A C Campi-Azevedo, E Rocha-Vieira
Our objective was to determine lipid peroxidation and nuclear factor-κB (NF-κB) activation in skeletal muscle and the plasma cytokine profile following maximum progressive swimming. Adult male Swiss mice (N = 15) adapted to the aquatic environment were randomly divided into three groups: immediately after exercise (EX1), 3 h after exercise (EX2) and control. Animals from the exercising groups swam until exhaustion, with an initial workload of 2% of body mass attached to the tail. Control mice did not perform any exercise but were kept immersed in water for 20 min...
June 2011: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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