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Nitrate and exercise

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https://www.readbyqxmd.com/read/28916479/dietary-nitrate-increases-vo2peak-and-performance-but-does-not-alter-ventilation-or-efficiency-in-patients-with-heart-failure-with-reduced-ejection-fraction
#1
Andrew R Coggan, Seth R Broadstreet, Kiran Mahmood, Deana Mikhalkova, Michael Madigan, Indra Bole, Soo Park, Joshua L Leibowitz, Ana Kadkhodayan, Deepak P Thomas, Dakkota Thies, Linda R Peterson
BACKGROUND: Patients with heart failure with reduced ejection fraction (HFrEF) exhibit lower efficiency, dyspnea, and diminished peak O2 uptake (VO2peak) during exercise. Dietary nitrate (NO3(-)), a source of nitric oxide (NO), has improved these measures in some studies of other populations. We determined the effects of acute NO3(-) ingestion on exercise responses in eight patients with HFrEF using a randomized, double-blind, placebo-controlled, crossover design. METHODS AND RESULTS: Plasma NO3(-), nitrite (NO2(-)), and breath NO were measured at multiple time points and respiratory gas exchange was determined during exercise after ingestion of beetroot juice containing or devoid of 11...
September 12, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28911021/effects-of-lifestyle-modification-on-an-exaggerated-blood-pressure-response-to-exercise-in-normotensive-females
#2
Ryoma Michishita, Masanori Ohta, Masaharu Ikeda, Ying Jiang, Hiroshi Yamato
BACKGROUND: This study was designed to examine the effects of a lifestyle modification on the improvement in an exaggerated systolic blood pressure (SBP) response to exercise in normotensive females. METHODS: The subjects were 78 normotensive females with (n = 25) and without (n = 53) an exaggerated SBP response to exercise who were not taking any medications. An exaggerated SBP response to exercise was defined according to the criteria of the Framingham Study (peak SBP: ≥190 mm Hg)...
October 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28887315/inorganic-nitrate-in-angina-study-a-randomized-double-blind-placebo-controlled-trial
#3
Konstantin Schwarz, Satnam Singh, Satish K Parasuraman, Amelia Rudd, Lee Shepstone, Martin Feelisch, Magdalena Minnion, Shakil Ahmad, Melanie Madhani, John Horowitz, Dana K Dawson, Michael P Frenneaux
BACKGROUND: In this double-blind randomized placebo-controlled crossover trial, we investigated whether oral sodium nitrate, when added to existing background medication, reduces exertional ischemia in patients with angina. METHODS AND RESULTS: Seventy patients with stable angina, positive electrocardiogram treadmill test, and either angiographic or functional test evidence of significant ischemic heart disease were randomized to receive oral treatment with either placebo or sodium nitrate (600 mg; 7 mmol) for 7 to 10 days, followed by a 2-week washout period before crossing over to the other treatment (n=34 placebo-nitrate, n=36 nitrate-placebo)...
September 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28864211/effects-of-spak-on-vascular-reactivity-and-nitric-oxide-production-in-endotoxemic-mice
#4
Chih-Chin Shih, Lin-Pin Hsu, Mei-Hui Liao, Sung-Sen Yang, Shung-Tai Ho, Chin-Chen Wu
Vasoplegia impedes therapeutic interventions to restore vascular tone, leading to severe hypotension, poor tissue perfusion, and multiple organ failure in septic shock. High levels of circulating nitric oxide (NO) play a crucial role in endotoxin-induced vascular hyporeactivity. Proinflammatory cytokines have been implicated in the induction of inducible NO synthase and overproduction of NO. Anti-inflammatory therapy can diminish NO formation and improve vascular hyporeactivity in septic shock. STE20/SPS1-realted proline/alanine-rich kinase (SPAK) has been reported to activate mitogen-activated protein kinase and contribute to intestinal inflammation...
August 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28832370/dietary-nitrate-as-modulator-of-physical-performance-and-cardiovascular-health
#5
Conor P Kerley
PURPOSE OF REVIEW: Early interventional trials reported improvements in cardiac and exercise outcomes with inorganic nitrate ingestion. The current review aims to provide a brief update of recent evidence regarding ergogenic and cardiovascular effects of dietary nitrate and practical recommendations. RECENT FINDINGS: Recent evidence has been inconsistent and questions remain regarding effective dose, duration, and source of nitrate and cohorts likely to benefit...
August 19, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28827246/usage-of-ambulance-transport-and-influencing-factors-in-acute-coronary-syndrome-a-cross-sectional-study-at-a-tertiary-centre-in-china
#6
Jingjing Ma, Jiali Wang, Wen Zheng, Jiaqi Zheng, Hao Wang, Guangmei Wang, He Zhang, Feng Xu, Yuguo Chen
OBJECTIVES: The aim of this study was to explore the choice of transportation mode to hospital in patients with acute coronary syndrome (ACS) and to determine the factors influencing the use of ambulance. DESIGN, SETTING AND PARTICIPANTS: This cross-sectional study was conducted in a tertiary and teaching hospital in China. The study was carried out between 24 August 2015 and 24 July 2016. A total of 828 patients with ACS presented at the emergency department (ED) were included...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28818578/can-exercise-training-counteract-doxorubicin-induced-oxidative-damage-of-testis-proteome
#7
José Magalhães, António Ascensão, Ana I Padrão, Inês M Aleixo, Estela Santos-Alves, Sílvia Rocha-Rodrigues, André Ferreira, Luis Korrodi-Gregório, Rui Vitorino, Rita Ferreira, Margarida Fardilha
The use of the chemotherapeutic drug doxorubicin (DOX) is limited by its toxicity in several organs such as testes. So, we analyzed the effect of endurance treadmill exercise training (EX) performed before sub-chronic DOX treatment on sperm count and motility, testes markers of oxidative damage and apoptosis. Tissue profiling of proteins more susceptible to oxidation was made to identify the molecular pathways regulated by oxidative modifications, as nitration and carbonylation. Twenty-four adult male rats were divided into four groups (n=6/group): sedentary saline (SED+SAL), sedentary sub-chronically injected with DOX (2mg-kg-1 per week, during 7 weeks; SED+DOX), 12 weeks trained saline (EX+SAL) and trained treated with DOX (EX+DOX)...
August 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28782598/physiological-and-performance-effects-of-nitrate-supplementation-during-roller-skiing-in-normoxia-and-normobaric-hypoxia
#8
Linn Nybäck, Caroline Glännerud, Gustav Larsson, Eddie Weitzberg, Oliver Michael Shannon, Kerry McGawley
The present study examined the effects of acute nitrate (NO3(-)) supplementation ingested in the form of concentrated beetroot juice on cross-country roller-ski performance in normoxia (N) and normobaric hypoxia (H). Eight competitive cross-country skiers (five males: age 22 ± 3 years, V·O2max 71.5 ± 4.7 mL kg(-1)·min(-1); three females: age 21 ± 1 years, V·O2max 58.4 ± 2.5 mL kg(-1)·min(-1)) were supplemented with a single dose of NO3(-)-rich beetroot juice (BRJ, ∼13 mmol NO3(-)) or a NO3(-)-depleted placebo (PL, ∼0 mmol NO3(-)) and performed 2 x 6-min submaximal exercise bouts and a 1000-m time-trial (TT) on a treadmill in N (20...
August 4, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28763003/short-term-effects-of-a-ready-to-drink-pre-workout-beverage-on-exercise-performance-and-recovery
#9
Patrick B Collins, Conrad P Earnest, Ryan L Dalton, Ryan J Sowinski, Tyler J Grubic, Christopher J Favot, Adriana M Coletta, Christopher Rasmussen, Mike Greenwood, Richard B Kreider
In a double-blind, randomized and crossover manner, 25 resistance-trained participants ingested a placebo (PLA) beverage containing 12 g of dextrose and a beverage (RTD) containing caffeine (200 mg), β-alanine (2.1 g), arginine nitrate (1.3 g), niacin (65 mg), folic acid (325 mcg), and Vitamin B12 (45 mcg) for 7-days, separated by a 7-10-day. On day 1 and 6, participants donated a fasting blood sample and completed a side-effects questionnaire (SEQ), hemodynamic challenge test, 1-RM and muscular endurance tests (3 × 10 repetitions at 70% of 1-RM with the last set to failure on the bench press (BP) and leg press (LP)) followed by ingesting the assigned beverage...
August 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28743821/the-effect-of-dietary-nitrate-supplementation-on-the-spatial-heterogeneity-of-quadriceps-deoxygenation-during-heavy-intensity-cycling
#10
Brynmor C Breese, David C Poole, Dai Okushima, Stephen J Bailey, Andrew M Jones, Narihiko Kondo, Tatsuro Amano, Shunsaku Koga
This study investigated the influence of dietary inorganic nitrate (NO3(-)) supplementation on pulmonary O2 uptake (V˙O2) and muscle deoxyhemoglobin/myoglobin (i.e. deoxy [Hb + Mb]) kinetics during submaximal cycling exercise. In a randomized, placebo-controlled, cross-over study, eight healthy and physically active male subjects completed two step cycle tests at a work rate equivalent to 50% of the difference between the gas exchange threshold and peak V˙O2 over separate 4-day supplementation periods with NO3(-)-rich (BR; providing 8...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28729387/leg-blood-flow-is-impaired-during-small-muscle-mass-exercise-in-patients-with-copd
#11
U W Iepsen, G W Munch, M Rugbjerg, C K Ryrsø, N H Secher, Y Hellsten, P Lange, B K Pedersen, P Thaning, S P Mortensen
Skeletal muscle blood flow is regulated to match the oxygen demand and dysregulation could contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). We measured leg hemodynamics and metabolites from vasoactive compounds in muscle interstitial fluid and plasma at rest, during one-legged knee-extensor exercise, and during arterial infusions of sodium nitroprusside (SNP) and acetylcholine (ACh), respectively. Ten patients with moderate to severe COPD and eight age- and sex-matched healthy controls were studied...
September 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28719765/beetroot-juice-is-more-beneficial-than-sodium-nitrate-for-attenuating-muscle-pain-after-strenuous-eccentric-bias-exercise
#12
Tom Clifford, Glyn Howatson, Daniel J West, Emma J Stevenson
The aim of this study was to compare the effects of beetroot juice (BTJ) and a nitrate only drink (sodium nitrate; SN) on indices of exercise-induced muscle damage (EIMD). Thirty recreationally active males consumed either BTJ (n=10), a nitrate matched SN drink (n=10) or an isocaloric placebo (PLA; n=10) immediately, 24 and 48 h after performing 100 drop jumps. To assess muscle damage, maximal isometric voluntary contractions (MIVC), countermovement jumps (CMJ), pressure-pain threshold (PPT), creatine kinase (CK) and high sensitivity C-reactive protein (hs-CRP) were measured pre, immediately post, 24, 48 and 72 h following the drop jumps...
July 18, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28684588/dietary-nitrate-supplementation-increases-acute-mountain-sickness-severity-and-sense-of-effort-during-hypoxic-exercise
#13
Gabriella M K Rossetti, Jamie Hugo Macdonald, Lee J Wylie, Samuel J Little, Victoria Newton, Benjamin Wood, Kieran A Hawkins, Rhys Beddoe, Hannah E Davies, Samuel James Oliver
Dietary nitrate supplementation enhances sea level performance and may ameliorate hypoxemia at high altitude. However, nitrate may exacerbate acute mountain sickness (AMS), specifically headache. This study investigated the effect of nitrate supplementation on AMS symptoms and exercise responses with 6h hypoxia. Twenty recreationally-active men (mean(SD): age 22(4) years, V̇O2max 51(6) mL·min-1·kg-1) completed this randomized double-blinded placebo-controlled crossover study. Twelve participants were classified as AMS- based on Environmental Symptom Questionnaire (AMS-C) score <0...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28684191/effects-of-oral-sodium-nitrate-on-forearm-blood-flow-oxygenation-and-exercise-performance-during-acute-exposure-to-hypobaric-hypoxia-4300%C3%A2-m
#14
Heath G Gasier, Anthony R Reinhold, Allison R Loiselle, Shawn E Soutiere, David M Fothergill
A reduction in oxygen transport contributes to impaired exercise capacity at high altitude. Since blood flow is mediated, in part, by nitric oxide (NO), we hypothesized that sodium nitrate provided before forearm grip exercise performed at a simulated altitude of 4300 m (hypobaric hypoxia (HH)) would increase forearm blood flow and oxygenation, and decrease the decrement in grip performance. In a double-blind, randomized crossover study, 10 healthy subjects (9 males and 1 female) performed continuous (CGrip) and repeated rhythmic (RGrip) isometric forearm exercise until task failure in normobaric normoxia (NN), 2...
July 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28675665/effects-of-different-rehabilitation-models-on-erythrocyte-deformability-and-nitrite-plus-nitrate-as-end-products-of-nitric-oxide-levels-in-elderly-women
#15
Katarzyna Filar-Mierzwa, Barbara Wójcik, Anna Marchewka, Zbigniew Dąbrowski, Jerzy Superata, Zdzisław Wiśniowski
AIM: The aim of the present study was to analyze the effects of two rehabilitation protocols, dance movement therapy exercises (DMT) and general rehabilitation exercises (GRE), on erythrocyte deformability and plasma levels of nitrite plus nitrate as end products of nitric oxide (NOx) in elderly women. METHODS: The study included 39 women aged 61-82 years, subjected to either GRE (n = 20) or DMT (n = 19). Women were subjected to 5-months programs of GRE and DMT, with each session lasting no longer than 45-50 min, and the intensity of exercising corresponding to no more than 40-60% of heart rate reserve...
July 4, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28674599/the-effect-of-betaine-on-nitrate-and-cardiovascular-response-to-exercise
#16
J Luke Pryor, S Tony Wolf, Gary Sforzo, Tom Swensen
Betaine (BT) supplementation improves selected markers of physical performance, however, the mechanism(s) by which this change occurs remains largely unknown. Some speculate that BT may increase circulating nitrate concentrations, improving physical performance by augmentation of endothelial nitric oxide production. The purpose of this study was to investigate the effects of acute BT supplementation and exercise on plasma nitrate levels and related cardiovascular response (CVR). Placebo and BT trials were administered in a cross-over, randomized, double-blind, and counterbalanced fashion...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28670117/dietary-beetroot-juice-effects-on-physical-performance-in-copd-patients-a-randomized-controlled-crossover-trial
#17
Anne Louise Friis, Carina Bjørnskov Steenholt, Anders Løkke, Mette Hansen
BACKGROUND AND OBJECTIVE: Dietary beetroot juice (BR) supplementation has been shown to reduce the oxygen (O2) consumption of standardized exercise and reduce resting blood pressure (BP) in healthy individuals. However, the physiological response of BR in chronic obstructive pulmonary disease (COPD) remains controversial. The objective was to test exercise performance in COPD, supplementing with higher doses of BR for a longer duration compared to previous trials in this patient group...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28658582/effect-of-acute-nitrate-ingestion-on-v%C3%AC-o2-response-at-different-exercise-intensity-domains
#18
Thaysa Ghiarone, Thays Ataide-Silva, Romulo Bertuzzi, Glenn Kevin McConell, Adriano Eduardo Lima-Silva
While nitrate supplementation influences oxygen uptake (V̇O2) response to exercise, this effect may be intensity dependent. The purpose of this study was to investigate the effect of acute nitrate supplementation on V̇O2 response during different exercise intensity domains in humans. Eleven men ingested 10 mg·kg(-1) body mass (8.76 ± 1.35 mmol) of sodium nitrate or sodium chloride (placebo) 2.5 h before cycling at moderate (90% of gas exchange threshold; GET), heavy (GET + 40% of the difference between GET and peak oxygen uptake (V̇O2peak), Δ 40) or severe (GET + 80% of the difference between GET and V̇O2peak, Δ 80) exercise intensities...
June 28, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28649204/effects-of-dietary-nitrate-supplementation-on-physiological-responses-cognitive-function-and-exercise-performance-at-moderate-and-very-high-simulated-altitude
#19
Oliver M Shannon, Lauren Duckworth, Matthew J Barlow, Kevin Deighton, Jamie Matu, Emily L Williams, David Woods, Long Xie, Blossom C M Stephan, Mario Siervo, John P O'Hara
Purpose: Nitric oxide (NO) bioavailability is reduced during acute altitude exposure, contributing toward the decline in physiological and cognitive function in this environment. This study evaluated the effects of nitrate ([Formula: see text]) supplementation on NO bioavailability, physiological and cognitive function, and exercise performance at moderate and very-high simulated altitude. Methods:Ten males (mean (SD): [Formula: see text]: 60.9 (10.1) ml·kg(-1)·min(-1)) rested and performed exercise twice at moderate (~14...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28622359/aerobic-exercise-protects-against-pressure-overload-induced-cardiac-dysfunction-and-hypertrophy-via-%C3%AE-3-ar-nnos-no-activation
#20
Bin Wang, Ming Xu, Wenju Li, Xiaoli Li, Qiangsun Zheng, Xiaolin Niu
Aerobic exercise confers sustainable protection against cardiac hypertrophy and heart failure (HF). Nitric oxide synthase (NOS) and nitric oxide (NO) are known to play an important role in exercise-mediated cardioprotection, but the mechanism of NOS/NO stimulation during exercise remains unclear. The aim of this study is to determine the role of β3-adrenergic receptors (β3-ARs), NOS activation, and NO metabolites (nitrite and nitrosothiols) in the sustained cardioprotective effects of aerobic exercise. An HF model was constructed by transverse aortic constriction (TAC)...
2017: PloS One
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