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Nitrate and exercise

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https://www.readbyqxmd.com/read/28514395/-impact-of-shock-wave-therapy-on-the-clinical-and-functional-status-of-patients-with-coronary-heart-disease
#1
S T Matskeplishvili, B M Borbodoeva, E U Asymbekova, A Z Rakhimov, N K Akhmedyarova, K B Kataeva, Yu I Buziashvili
AIM: To study of the impact of shock-wave therapy (SWT) on the functional status of patients with coronary heart disease (CHD). SUBJECTS AND METHODS: Thirty-four CHD patients (including 33 men) with left ventricular (LV) asynergic segments, as evidenced by echocardiography (EchoCG), were examined. Their mean age was 60.1±1.76 years. All the patients received a SWT cycle according to the standard scheme. The patient examination protocol involved EchoCG, dobutamine EchoCG, treadmill exercise EchoCG, and tissue Doppler EchoCG, which were performed at baseline, immediately and one month after the end of a SWT cycle...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28509889/the-role-of-nitrates-in-the-management-of-stable-ischemic-heart-disease-a-review-of-the-current-evidence-and-guidelines
#2
Mehul A Pragani, Karan P Desai, Doralisa Morrone, Mandeep S Sidhu, William E Boden
Coronary artery disease is the leading cause of mortality in the United States and can result in significant morbidity. In particular, stable ischemic heart disease (SIHD) is a condition that affects nearly 9 million individuals in the United States alone, with substantial annual health care costs related to recurrent medical visits and chronic disease management. Nitrates form a cornerstone of SIHD management by reducing myocardial oxygen consumption and increasing exercise capacity by several mechanisms, including increasing epicardial blood flow through vasodilation and decreased vascular resistance, blunting coronary steal, and reducing preload...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28476923/acute-beetroot-juice-supplementation-on-sympathetic-nerve-activity-a-randomized-double-blind-placebo-controlled-proof-of-concept-study
#3
Karambir Notay, Anthony V Incognito, Philip J Millar
Acute dietary nitrate supplementation reduces resting blood pressure in healthy normotensives. This response is attributed to increased nitric oxide bioavailability and peripheral vasodilation, though nitric oxide also tonically inhibits central sympathetic outflow. We hypothesized that acute dietary nitrate (NO3(-)) supplementation using beetroot (BR) juice would reduce blood pressure and muscle sympathetic nerve activity (MSNA) at rest and during exercise. Fourteen participants (7 men, 25±10 years) underwent blood pressure and MSNA measurements before and after (165-180 minutes) ingestion of 70ml high-nitrate (~6...
May 5, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28476756/indie-hfpef-inorganic-nitrite-delivery-to-improve-exercise-capacity-in-heart-failure-with-preserved-ejection-fraction-rationale-and-design
#4
Yogesh N V Reddy, Gregory D Lewis, Sanjiv J Shah, Martin LeWinter, Marc Semigran, Victor G Davila-Roman, Kevin Anstrom, Adrian Hernandez, Eugene Braunwald, Margaret M Redfield, Barry A Borlaug
Approximately half of patients with heart failure have preserved ejection fraction. There is no proven treatment that improves outcome. The pathophysiology of heart failure with preserved ejection fraction is complex and includes left ventricular systolic and diastolic dysfunction, pulmonary vascular disease, endothelial dysfunction, and peripheral abnormalities. Multiple lines of evidence point to impaired nitric oxide (NO)-cGMP bioavailability as playing a central role in each of these abnormalities. In contrast to traditional organic nitrate therapies, an alternative strategy to restore NO-cGMP signaling is via inorganic nitrite...
May 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28445231/the-effects-of-multi-day-vs-single-pre-exercise-nitrate-supplement-dosing-on-simulated-cycling-time-trial-performance-and-skeletal-muscle-oxygenation
#5
Edward Jo, Michelle Fischer, Alexandra T Auslander, Alan Beigarten, Bruce Daggy, Ken Hansen, Lisa Kessler, Adam Osmond, Hong Wang, Rachel Wes
A transient augmentation in the metabolic efficiency of skeletal muscle is the purported basis for dietary nitrate supplementation amongst competitive and recreational athletes alike. Previous studies support the ergogenic effects of nitrate supplementation as findings indicated improved microvascular blood flow, exercise economy, and performance with relatively short-term supplementation. As with most ergogenic aids, the optimum duration of supplementation prior to performance or competition, i.e. loading phase, is a critical determinant for efficacy...
April 18, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28422539/the-effect-of-nitrate-supplementation-on-cycling-performance-in-the-heat-in-well-trained-cyclists
#6
Joseph A McQuillan, Julia R Casadio, Deborah K Dulson, Paul B Laursen, Andrew E Kilding
PURPOSE: The aim of this study was to determine the effect of NO3(-) consumption on measures of perception, thermoregulation and cycling performance in hot conditions. METHODS: Using a randomised, double-blind, crossover-design, 8 well-trained cyclists (mean ± SD: age: 25 ± 8 y, V̇O2peak: 64 ± 5 ml·kg(-1)·min(-1)) performed 2 separate trials, in hot (35°C, 60% relative humidity) environments, having ingested either 140 ml NO3(-)-rich beetroot juice ~8 mmol NO3(-) (NIT), or placebo (PLA), daily for 3-days with a 7-day washout period separating trials...
April 19, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28403861/cardiac-shock-wave-therapy-in-the-treatment-of-coronary-artery-disease-systematic-review-and-meta-analysis
#7
REVIEW
Greta Burneikaitė, Evgeny Shkolnik, Jelena Čelutkienė, Gitana Zuozienė, Irena Butkuvienė, Birutė Petrauskienė, Pranas Šerpytis, Aleksandras Laucevičius, Amir Lerman
AIM: To systematically review currently available cardiac shock-wave therapy (CSWT) studies in humans and perform meta-analysis regarding anti-anginal efficacy of CSWT. METHODS: The Cochrane Controlled Trials Register, Medline, Medscape, Research Gate, Science Direct, and Web of Science databases were explored. In total 39 studies evaluating the efficacy of CSWT in patients with stable angina were identified including single arm, non- and randomized trials. Information on study design, subject's characteristics, clinical data and endpoints were obtained...
April 12, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28332118/nutrition-and-training-influences-on-the-regulation-of-mitochondrial-adenosine-diphosphate-sensitivity-and-bioenergetics
#8
REVIEW
Graham P Holloway
Since the seminal finding almost 50 years ago that exercise training increases mitochondrial content in skeletal muscle, a considerable amount of research has been dedicated to elucidate the mechanisms inducing mitochondrial biogenesis. The discovery of peroxisome proliferator-activated receptor γ co-activator 1α as a major regulator of exercise-induced gene transcription was instrumental in beginning to understand the signals regulating this process. However, almost two decades after its discovery, our understanding of the signals inducing mitochondrial biogenesis remain poorly defined, limiting our insights into possible novel training modalities in elite athletes that can increase the oxidative potential of muscle...
March 2017: Sports Medicine
https://www.readbyqxmd.com/read/28327503/beetroot-juice-supplementation-improves-high-intensity-intermittent-type-exercise-performance-in-trained-soccer-players
#9
Jean Nyakayiru, Kristin L Jonvik, Jorn Trommelen, Philippe J M Pinckaers, Joan M Senden, Luc J C van Loon, Lex B Verdijk
It has been shown that nitrate supplementation can enhance endurance exercise performance. Recent work suggests that nitrate ingestion can also increase intermittent type exercise performance in recreational athletes. We hypothesized that six days of nitrate supplementation can improve high-intensity intermittent type exercise performance in trained soccer players. Thirty-two male soccer players (age: 23 ± 1 years, height: 181 ± 1 m, weight: 77 ± 1 kg, playing experience: 15.2 ± 0.5 years, playing in the first team of a 2nd or 3rd Dutch amateur league club) participated in this randomized, double-blind cross-over study...
March 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28319269/withdrawn-trimetazidine-for-stable-angina
#10
REVIEW
Agustín Ciapponi, Rudolf Pizarro, Jeff Harrison
BACKGROUND: Patients with stable angina not controlled by monotherapy with nitrates, beta blockers, or calcium channel blockers are often treated with combinations of these drugs. There may be adverse effects from, or contraindications to, the use of combinations. In low risk groups, medical treatment appears to be as good an option as percutaneous transluminal coronary angioplasty in terms of averting myocardial infarction, death, or subsequent revascularization. Revascularization procedures are too costly or inaccessible for many patients in developing countries therefore effective and safe medical treatment is needed...
March 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28296653/involvement-of-hypothalamic-nitric-oxide-signaling-in-the-modulation-of-a-rat-s-exercise-capacity
#11
Hongyu Liu, Jinjuan Xue
PURPOSE: The aim of this study was to explore the effect of nitric oxide (NO) in some regions of the hypothalamus on exercise capacity. MATERIALS AND METHODS: To assess the role of central NO in exercise capacity, L-arginine (L-Arg, a precursor of NO synthesis), NG-nitro-L-arginine methyl ester (L-NAME, a NO synthase inhibitor), or placebo saline was injected into the lateral cerebral ventricle of rats once a day for 4 consecutive days. Thereafter, an one-time exhaustive treadmill exercise was performed, and the levels of nitrate/nitrite, as a marker of NO production, in blood plasma and hypothalamus were assayed...
May 3, 2017: Neuroreport
https://www.readbyqxmd.com/read/28294866/-treatment-of-patients-with-stable-ischemic-heart-disease-in-real-clinical-practice-in-russia-the-choice-2-program
#12
G Glezer M, On Behalf Of The Choice-Study Participants On Behalf Of The Choice-Study Participants
OBJECTIVE: in the framework of an open post-marketing observational national program CHOICE-2 to assess correspondence between recommendations for management of patients with stable angina and actual clinical practice, as well as to assess effect of treatment with cytoprotector trimetazidine on clinical course of the disease. MATERIAL AND METHODS: Participating physicians (n=185 from 46 regions of Russian Federation) recruited 896 patients with ischemic heart disease (IHD)...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28251402/dietary-nitrate-supplementation-enhances-short-but-not-longer-duration-running-time-trial-performance
#13
Oliver Michael Shannon, Matthew John Barlow, Lauren Duckworth, Emily Williams, Georgina Wort, David Woods, Mario Siervo, John Paul O'Hara
PURPOSE: This study evaluated the effects of dietary nitrate (NO3(-)) supplementation on physiological functioning and exercise performance in trained runners/triathletes conducting short and longer-distance treadmill running time-trials (TT). METHOD: Eight trained male runners or triathletes completed four exercise performance tests comprising a 10 min warm up followed by either a 1500 or 10,000 m treadmill TT. Exercise performance tests were preceded 3 h before the exercise by supplementation with either 140 ml concentrated nitrate-rich (~12...
April 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28243471/a-single-dose-of-beetroot-gel-rich-in-nitrate-does-not-improve-performance-but-lowers-blood-glucose-in-physically-active-individuals
#14
Julia Vasconcellos, Diego Henrique Silvestre, Diego Dos Santos Baião, João Pedro Werneck-de-Castro, Thiago Silveira Alvares, Vânia M Flosi Paschoalin
Background. Beetroot consumption has been proposed to improve exercise performance, since the nitrate content of this food is able to stimulate the synthesis of nitric oxide. Objective. The acute effect of 100 g of a beetroot gel containing ~10 mmol of nitrate was tested on the nitric oxide synthesis, on metabolic and biochemical parameters, and on performance in physically active individuals. Methods. Through a double blind, crossover, placebo-controlled study, 25 healthy runners ingested a single dose of beetroot and placebo gels...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28220388/real-world-evidence-for-the-antianginal-efficacy-of-trimetazidine-from%C3%A2-the%C3%A2-russian-observational-choice-2-study
#15
Maria Glezer
INTRODUCTION: The guidelines recommend a beta-blocker or calcium channel blocker as the first-line medication for angina, supplemented by other agents for additional symptoms. One such agent is trimetazidine (TMZ), which has been shown to reduce the frequency of anginal episodes and improve exercise performance without affecting haemodynamic parameters. However, extensive real-world evidence for its efficacy in combination with first-line therapies has been lacking. METHODS: The aim of this large-scale, Russian, multicentre, 6-month, open-label, prospective observational study was to assess the effect of adding TMZ modified release 35 mg bid to background antianginal therapy in the real-world clinical setting...
February 20, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28219917/isosorbide-dinitrate-with-or-without-hydralazine-does-not-reduce-wave-reflections-left-ventricular-hypertrophy-or-myocardial-fibrosis-in-patients-with-heart-failure-with-preserved-ejection-fraction
#16
Payman Zamani, Scott Akers, Haideliza Soto-Calderon, Melissa Beraun, Maheswara R Koppula, Swapna Varakantam, Deepa Rawat, Prithvi Shiva-Kumar, Philip G Haines, Jesse Chittams, Raymond R Townsend, Walter R Witschey, Patrick Segers, Julio A Chirinos
BACKGROUND: Wave reflections, which are increased in patients with heart failure with preserved ejection fraction, impair diastolic function and promote pathologic myocardial remodeling. Organic nitrates reduce wave reflections acutely, but whether this is sustained chronically or affected by hydralazine coadministration is unknown. METHODS AND RESULTS: We randomized 44 patients with heart failure with preserved ejection fraction in a double-blinded fashion to isosorbide dinitrate (ISDN; n=13), ISDN+hydralazine (ISDN+hydral; n=15), or placebo (n=16) for 6 months...
February 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28192673/the-benefit-of-a-supplement-with-the-antioxidant-melatonin-on-redox-status-and-muscle-damage-in-resistance-trained-athletes
#17
Roberto C Leonardo-Mendonça, Javier Ocaña-Wilhelmi, Tomás de Haro, Carlos de Teresa-Galván, Eduardo Guerra-Hernández, Iryna Rusanova, Marisol Fernández-Ortiz, Ramy K A Sayed, Germaine Escames, Darío Acuña-Castroviejo
Previous data showed that the administration of high doses of melatonin improved the circadian system in athletes. Here, we investigated in the same experimental paradigm whether the antioxidant properties of melatonin has also beneficial effects against exercise-induced oxidative stress and muscle damage in athletes. Twenty-four athletes were treated with 100 mg·day(-1) of melatonin or placebo 30 min before bedtime during 4 weeks in a randomized double-blind scheme. Exercise intensity was higher during the study that before starting it...
February 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28182502/effect-of-dietary-nitrate-supplementation-on-swimming-performance-in-trained-swimmers
#18
Sam Lowings, Oliver Michael Shannon, Kevin Deighton, Jamie Matu, Matthew John Barlow
Nitrate supplementation appears to be most ergogenic when oxygen availability is restricted and subsequently may be particularly beneficial for swimming performance due to the breath-hold element of this sport. This represents the first investigation of nitrate supplementation and swimming time-trial (TT) performance. In a randomised double-blind repeated-measures crossover study, ten (5male, 5female) trained swimmers ingested 140ml nitrate-rich (~12.5mmol nitrate) or nitrate-depleted (~0.01mmol nitrate) beetroot juice...
February 9, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28179228/dietary-nitrate-does-not-reduce-oxygen-cost-of-exercise-or-improve-muscle-mitochondrial-function-in-mitochondrial-myopathy-patients
#19
Miranda Nabben, Joep P J Schmitz, Jolita Ciapaite, Carlijn M P Le Clercq, Natal A van Riel, Harm R Haak, Klaas Nicolay, Irenaeus F de Coo, Hubert J M Smeets, Stephan F Praet, Luc J C van Loon, Jeanine J Prompers
Muscle weakness and exercise intolerance negatively affect the quality of life of mitochondrial myopathy patients. Short-term dietary nitrate supplementation has been shown to improve exercise performance and reduce oxygen cost of exercise in healthy humans and trained athletes. We investigated if 1 week of dietary inorganic nitrate supplementation decreases the oxygen cost of exercise and improves mitochondrial function in mitochondrial myopathy patients. Ten mitochondrial myopathy patients (40 ± 5 years, maximal whole-body oxygen uptake = 21...
February 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28165641/effects-of-nitrate-supplementation-in-trained-and-untrained-muscle-is-modest-with-initial-high-plasma-nitrite-levels
#20
Peter M Christensen, Nanna K Petersen, Signe N Friis, Eddie Weitzberg, Lars Nybo
Nitrate (NO3(-) ) supplementation resulting in higher plasma nitrite (NO2(-) ) is reported to lower resting mean arterial blood pressure (MAP) and oxygen uptake (VO2 ) during submaximal exercise in non-athletic populations, whereas effects in general are absent in endurance trained individuals. To test whether physiological effects of NO3(-) supplementation depend on local muscular training status or cardiovascular fitness, male endurance-trained cyclists (CYC, n=9, VO2 -max: 64±3 ml/min/kg; mean±SD) and recreational active subjects serving as a control group (CON, n=8, 46±3 ml/min/kg), acutely consumed nitrate-rich beetroot-juice ([NO3(-) ] ~9 mmol) (NIT) or placebo (PLA) with assessment of resting MAP and energy expenditure during moderate intensity (~50% VO2 -max) and incremental leg cycling (LEG-ex) and arm cranking exercise (ARM-ex)...
February 6, 2017: Scandinavian Journal of Medicine & Science in Sports
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