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Uterine adhesions

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https://www.readbyqxmd.com/read/28323221/laparoscopic-promontohysteropexy-during-pregnancy
#1
L Pirtea, O Balint, C Secosan, R Ilina, D Grigoras
STUDY OBJECTIVE: to present a case of uterine prolapse in a 10 weeks pregnant patient that was successfully treated by laparoscopic promontohysteropexy. To our knowledge, this is the first case of laparoscopic promontopexy during pregnancy to ever be reported in literature. DESIGN: step by step explanation of the surgery using video SETTING: Uterine prolapse is a rare condition in young patients and extremely are in pregnant women. The incidence of uterine prolapse during pregnancy reported in literature is 1 per 10...
March 17, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28301988/the-influence-of-lipid-and-proinflammatory-status-on-maternal-uterine-blood-flow-in-women-with-late-onset-gestational-diabetes
#2
Fernando Bugatto, Rocío Quintero-Prado, Francisco M Visiedo, José M Vilar-Sánchez, Alejandro Figueroa-Quiñones, Cristina López-Tinoco, Rafael Torrejón, José L Bartha
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with increased proinflammatory cytokines and is also associated with adverse cardiovascular disease (CVD) outcomes later in life. We aim to evaluate the relationships between uterine arteries vascularization and endothelial dysfunction markers, proinflammatory cytokines, and glycemic and lipid profile in women with GDM. METHODS: Fifty pregnant women were recruited at the third trimester of pregnancy for a prospective cohort study...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28299994/the-changes-of-cytoskeletal-proteins-induced-by-the-fast-effect-of-estrogen-in-mouse-blastocysts-and-its-roles-in-implantation
#3
Shi-Mao Zhang, Lin-Lin Yu, Ting Qu, Ying Hu, Dong-Zhi Yuan, Sheng Zhang, Qian Xu, You-Bo Zhao, Jin-Hu Zhang, Li-Min Yue
It is necessary for estrogen to activate mouse blastocysts, so that they can attach to endometrial epithelium in implantation and in our previous research, we have proved estrogen can induce a fast increase in intracellular calcium of mouse blastocysts through acting on G protein-coupled receptor 30 (GPR30), which further promotes their implantation. Moreover, there has been evidence that cytoskeletal proteins are involved in integrin-mediated adhesion of many kinds of cells, which also plays an important role in implantation...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28294441/accuracy-of-pre-operative-real-time-dynamic-transvaginal-ultrasound-sliding-sign-in-prediction-of-pelvic-adhesions-in-women-with-previous-abdominopelvic-surgery-a-prospective-multicenter-double-blinded-study
#4
Amira Ayachi, Rim Bouchahda, Sadok Derouich, Lassaad Mkaouer, Mehdi Kehila, Hassine Abouda, Badis Channoufi, Maha Bouyahia, Marouen Braham, Fethi Zhioua, Haifa Bouchahda, Mechaal Mourali
OBJECTIVE: To highlight the role of the transvaginal ultrasound sliding sign in predicting pelvic adhesions in women with a previous history of abdominopelvic surgery. METHODS: Multicenter prospective, interventional, double blinded study. Patients were examined before the laparoscopy or laparotomy, in gynaecological position, with transvaginal ultrasound (TVU) probe to assess vesico uterine pouch, uterus, ovaries, pouch of Douglas by analysing the gliding between two structures...
March 13, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28285950/human-amniotic-mesenchymal-stromal-cell-transplantation-improves-endometrial-regeneration-in-rodent-models-of-intrauterine-adhesions
#5
Lu Gan, Hua Duan, Qian Xu, Yi-Qun Tang, Jin-Jiao Li, Fu-Qing Sun, Sha Wang
BACKGROUND AIMS: Intrauterine adhesion (IUA) is a common uterine cavity disease characterized by the unsatisfactory regeneration of damaged endometria. Recently, stem cell transplantation has been proposed to promote the recovery process. Here we investigated whether human amniotic mesenchymal stromal cells (hAMSCs), a valuable resource for transplantation therapy, could improve endometrial regeneration in rodent IUA models. METHODS: Forty female Sprague-Dawley rats were randomly assigned to five groups: normal, sham-operated, mechanical injury, hAMSC transplantation, and negative control group...
March 9, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28259404/genetic-and-functional-analysis-of-the-bovine-uterine-microbiota-part-i-metritis-versus-healthy-cows
#6
M L S Bicalho, V S Machado, C H Higgins, F S Lima, R C Bicalho
Metritis is a uterine disease that affects 10 to 30% of all lactating dairy cows and has detrimental effects on reproductive performance, milk production, and survival. Data regarding the identity and abundance of bacterial genes governing traits such as virulence, antibiotic resistance, and stress responses could enable identification of previously unknown agents that play a role in metritis pathogenesis. Moreover, such knowledge could lead to the development of improved treatments or preventive methods. Therefore, the objectives of this study were to characterize the uterine microbial population and to differentiate, for the first time, the microbial functional diversity in cows with metritis versus healthy cows...
March 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28254225/hydrogen-sulfide-prevents-postoperative-adhesion-in-a-rat-uterine-horn-model
#7
Ye Xia, Yi Zhun Zhu, Congjian Xu
OBJECTIVE: Abdominal adhesions are primarily severe postoperative complications that can cause gynecological problems such as infertility and chronic pelvic pain. Inflammatory mediators are significantly related to adhesion formation, and hydrogen sulfide plays a significant anti-inflammatory role in multiple physiological processes. Therefore, the effect of NaHS, a hydrogen sulfide donor, on postoperative adhesion formation was examined in a rat uterine horn model. MATERIALS AND METHODS: A rat uterine horn model was created to evaluate whether NaHS, a hydrogen sulfide donor, could decrease postoperative adhesion formation...
February 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28253866/expression-of-sox2-nanog-and-oct4-in-a-mouse-model-of-lipopolysaccharide-induced-acute-uterine-injury-and-intrauterine-adhesions
#8
Li Xiao, Yong Song, Wei Huang, Shiyuan Yang, Jing Fu, Xue Feng, Min Zhou
BACKGROUND: Activation of inflammation-mediated endometrial injury is suggested to play a decisive role in pathogenesis of intrauterine adhesion (IUA). The stem cell theory of endometrial diseases has been given a hotspot, in that human endometrial stem cells have been isolated from the endometrium. Three transcription factors that play key roles in maintaining pluripotency and self-renewal in stem cells are sex-determining region Y-box2 (SOX2), Nanog homebox (NANOG), and octamer-binding protein (OCT4), which may be responsible for the damage or repair process of uterine endometrium...
March 3, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28251159/effects-of-aspirin-and-intrauterine-balloon-on-endometrial-repair-and-reproductive-prognosis-in-patients-with-severe-intrauterine-adhesion-a-prospective-cohort-study
#9
Yuqing Chen, Lixiang Liu, Yuanna Luo, Minghui Chen, Yang Huan, Ruili Fang
This study aimed to investigate the effects of estrogen in combination with aspirin and intrauterine balloon on the uterine endometrial repair and reproductive prognosis in patients after surgery for severe intrauterine adhesion (sIUA). We prospectively recruited 114 patients with sIUA. Intrauterine device (IUD) was placed and oral estrogen was administered after surgery. Patients were divided into control group and aspirin group. In addition, patients in aspirin group were subdivided into nonballoon group and balloon group...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28250242/itgav-alpha-v-integrins-bind-spp1-osteopontin-to-support-trophoblast-cell-adhesion
#10
James W Frank, Heewon Seo, Robert C Burghardt, Kayla J Bayless, Gregory A Johnson
Attachment of the conceptus trophoblast (Tr) to the uterine luminal epithelium (LE) is critical for successful implantation. This study determined whether alpha v (av) integrins (ITGAV) directly mediate porcine trophoblast cell adhesion to secreted phosphoprotein 1 [SPP1, also known as osteopontin (OPN)], and examined the temporal/spatial expression of ITGAV, beta 3 (b3, ITGB3) and beta 6 (b6, ITGB6) integrin subunits, and SPP1, at the uterine-placental interface of pigs. Knockdown of ITGAV in a porcine Tr (pTr2) cells by siRNA reduced pTr2 attachment to SPP1...
March 1, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28239559/gene-profiling-the-window-of-implantation-microarray-analyses-from-human-and-rodent-models
#11
Jennifer L Herington, Yan Guo, Jeff Reese, Bibhash C Paria
Poor uterine receptivity leads to implantation defects or failure. Identification of uterine molecules crucial to uterine receptivity and/or embryo implantation provides the opportunity to design a diagnostic screening toolkit for uterine receptivity or targeted drug discovery for treating implantation-based infertility. In this regard, gene-profiling studies performed in humans and rodents have identified numerous genes involved in the transcriptional regulation of uterine receptivity and embryo implantation...
December 2016: J Reprod Health Med
https://www.readbyqxmd.com/read/28217667/the-efficacy-of-pre-delivery-prophylactic-trans-catheter-arterial-balloon-occlusion-of-bilateral-internal-iliac-artery-in-patients-with-suspected-placental-adhesion
#12
Yoon Jin Cho, Yong Taek Oh, Suk Young Kim, Ju Young Kim, Sun Young Jung, Seung Joo Chon, Jeong Ho Kim, Sung Su Byun
OBJECTIVE: Prophylactic trans-catheter arterial balloon occlusion (PTABO) before cesarean section of placenta previa totalis has been introduced to prevent massive hemorrhage. The purpose of this study is to evaluate the clinical usefulness of PTABO in cases of suspected placental adhesion and to examine antepartal risk factors and perinatal outcomes in women with placental adhesion. METHODS: Between January 2012 and December 2015, 77 patients who had undergone ultrasonography for evaluation of placenta previa were enrolled in this study...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28214855/fatty-acid-binding-protein-4-in-endometrial-epithelium-is-involved-in-embryonic-implantation
#13
Peng Wang, Qiuyuan Zhu, Huilian Peng, Mengkai Du, Minyue Dong, Hanzhi Wang
AIMS: To clarify the role of fatty acid-binding protein 4 (FABP4) of endometrial epithelial cell in the establishment and maintenance of pregnancy and the involvement in the pathogenesis of pregnancy loss. METHODS: The expression of FABP4 and uterine receptive factor (LIF, Integrin-β3 and Claudin 4) was determined by Western blotting or quantitative PCR. FABP4 siRNA was used to silence FABP4 while FABP4 inhibitor was used to inhibit the function of FABP4 in endometrial epithelial cell...
January 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28195086/altered-expressions-of-notch-1-signaling-proteins-and-beta-catenin-in-progression-of-carcinoma-in-situ-into-squamous-carcinoma-of-uterine-cervix
#14
Na-Hye Myong
BACKGROUND: Activation of Notch-1 signaling pathway and loss of membranous beta-catenin have been known to play key roles in the progression of uterine cervix cancer and thus this study focused any alteration in the expression patterns for Notch-1, p53, and cyclin D1 as well as beta-catenin in squamous carcinoma in situ (CIS) and invasive squamous carcinomas to investigate their roles in the progression of CIS to squamous carcinomas. MATERIALS AND METHODS: Three Notch-1 signaling proteins, such as Notch-1, TP53, and cyclin D1, and a component of cell adhesion complex, beta-catenin, were immunohistochemically stained in 112 uterine cervical tumors including 74 CIS and 38 invasive squamous carcinomas (11 microinvasive and 27 invasive carcinomas)...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28187094/extraperitoneal-radical-trachelectomy-with-pelvic-lymphadenectomy-a-novel-fertility-preserving-option-for-early-stage-cervical-cancer-patients
#15
Seiji Mabuchi, Tadashi Kimura
OBJECTIVE: Radical trachelectomy combined with pelvic lymphadenectomy has been used to treat early stage cervical cancer patients who wish to preserve their fertility. Although vaginal, abdominal, laparoscopic, and robotic approaches have been used during this procedure, all of these approaches cause peritoneal damage, which could result in periadnexal adhesion. The aim of the present study was to introduce and discuss a novel fertility-preserving option, extraperitoneal radical trachelectomy with pelvic lymphadenectomy...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28179197/laparoendoscopic-single-site-total-laparoscopic-hysterectomy-clinical-factors-that-affect-operative-times-and-techniques-to-overcome-difficulties
#16
In Cheul Jeung, Yong Seok Lee, Min Jong Song, Eun Kyung Park
STUDY OBJECTIVE: To compare surgical outcomes of patients who underwent laparoendoscopic single-site total laparoscopic hysterectomy (LESS-TLH) with operative times <150 minutes and ≥150 minutes to determine the clinical factors that influence operative times. We also describe techniques that help overcome difficulties involved in this procedure. DESIGN: Retrospective study. DESIGN: Classification: Canadian Task Force Classification II-2...
February 4, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28178664/identification-of-distinct-molecular-subtypes-of-uterine-carcinosarcoma
#17
Yang An, Haojie Wang, Jingyao Jie, Yitai Tang, Weijuan Zhang, Shaoping Ji, Xiangqian Guo
Uterine carcinosarcoma (UCS) is a rare but lethal neoplasm with high metastasis and recurrence rate, and to date, no molecular classification of UCS has been defined to achieve targeted therapies. In this study, we identified two distinct molecular subtypes of UCS with distinct gene expression patterns and clinicopathologic characteristics. Subtype I UCS recapitulates low-grade UCS, in contrast subtype II UCS represents high-grade UCS with higher tumor invasion rate and tumor weight. Interestingly, subtype I UCS is characterized by cell adhesion and apoptosis pathways, whereas genes over-expressed in subtype II UCS are more involved in myogenesis/muscle development...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28170094/efficacy-of-freeze-dried-amnion-graft-following-hysteroscopic-adhesiolysis-of-severe-intrauterine-adhesions
#18
Lu Gan, Hua Duan, Fu-Qing Sun, Qian Xu, Yi-Qun Tang, Sha Wang
OBJECTIVE: To evaluate the efficacy of freeze-dried amnion graft for prevention of intrauterine adhesion (IUA) reformation after hysteroscopic adhesiolysis. METHODS: A prospective randomized controlled trial was conducted among 88 women with severe IUAs who underwent hysteroscopic adhesiolysis at Beijing Obstetrics and Gynecology Hospital between July 15, 2015, and July 1, 2016. All participants had a balloon inserted into the uterine cavity for 1 week. Sterilized freeze-dried amnion graft covered the balloon portion of the Foley catheter among patients allocated to the amnion group (n=44), whereas patients in the control group (n=44) did not receive the graft...
February 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28167787/up-regulation-of-cd81-inhibits-cytotrophoblast-invasion-and-mediates-maternal-endothelial-cell-dysfunction-in-preeclampsia
#19
Li Shen, Zhenyu Diao, Hai-Xiang Sun, Gui-Jun Yan, Zhiqun Wang, Ruo-Tian Li, Yimin Dai, Jingmei Wang, Jie Li, Hailing Ding, Guangfeng Zhao, Mingming Zheng, Pingping Xue, Mo Liu, Yan Zhou, Yali Hu
Preeclampsia (PE) is initiated by abnormal placentation in the early stages of pregnancy, followed by systemic activation of endothelial cells of the maternal small arterioles in the late second or third trimester (TM) of pregnancy. During normal pregnancy, placental cytotrophoblasts (CTBs) invade the maternal uterine wall and spiral arteries, whereas this process is interrupted in PE. However, it is not known how the malformed placenta triggers maternal endothelial crisis and the associated manifestations...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28105226/expression-of-epidermal-growth-factor-like-domain-7-may-be-a-predictive-marker-of-the-effect-of-neoadjuvant-chemotherapy-for-locally-advanced-uterine-cervical-cancer
#20
Makoto Yamauchi, Takeshi Fukuda, Takuma Wada, Masaru Kawanishi, Kenji Imai, Reiko Tasaka, Tomoyo Yasui, Toshiyuki Sumi
Neoadjuvant chemotherapy (NAC) followed by hysterectomy may be effective for the treatment of locally advanced uterine cervical cancer and improve patient prognosis. It is important to identify markers that are able to predict whether NAC may be successful. Epidermal growth factor-like domain 7 (EGFL7) regulates vascular sprouting in blood vessel formation. In numerous types of human cancer, EGFL7 is upregulated and inhibits endothelial cell adhesion molecules, decreasing vascular tightness and, thus, increasing vascular permeability...
December 2016: Oncology Letters
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