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Uterine adhesions

Yanfen Li, Malavika K Adur, Athilakshmi Kannan, Juanmahel Davila, Yuechao Zhao, Romana A Nowak, Milan K Bagchi, Indrani C Bagchi, Quanxi Li
Endometriosis, defined as growth of the endometrial cells outside the uterus, is an inflammatory disorder that is associated with chronic pelvic pain and infertility in women of childbearing age. Although the estrogen-dependence of endometriosis is well known, the role of progesterone in development of this disease remains poorly understood. In this study, we developed a disease model in which endometriosis was induced in the peritoneal cavities of immunocompetent female mice, and maintained with exogenous estrogen...
2016: PloS One
Whasun Lim, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
Eph and ephrin regulate diverse biological events such as proliferation, adhesion, migration, and angiogenesis through cell-to-cell interactions. However, little is known of their functional role and mechanisms of action in uterine endometrial cells. In the present study, we demonstrated the effects of the Eph and ephrin on interactions between blastocysts and endometrial luminal epithelial (pLE) cells in the pig that is regarded as an excellent biomedical animal model for research on the peri-implantation period of pregnancy...
October 24, 2016: Journal of Cellular Physiology
S Schäfer-Somi, S S Ay, D Kaya, M Sözmen, H B Beceriklisoy, A R Ağaoğlu, M Fındık, T van Haeften, S Aslan
Uterine tissue was collected from bitches after ovariohysterectomy at different times after ovulation. Samples were assigned to four groups: metestrous non-pregnant, day 10-12, n = 4; pre-implantation, day 10-12, n = 9; post-implantation, day 18-25, n = 13; mid-gestation, day 30-40, n = 7. RT-qPCR detection was performed for kiss1 and the G protein-coupled receptor 54 (GPR54, specific receptor for kisspeptin). In addition, immunohistochemistry was performed for detection of kisspeptin-10 (KP-10), GPR54, as well as pan-cytokeratin and vimentin...
October 23, 2016: Reproduction in Domestic Animals, Zuchthygiene
Kelsey L Shnaekel, Michael P Wendel, Nader Z Rabie, Everett F Magann
Objective: The aim of this review was to describe the risk factors, clinical and radiographic criteria, and management of this rare complication of pregnancy. Methods: A PubMed, Web of Science, and CINAHL search was undertaken with no limitations on the number of years searched. Results: There were 60 articles identified, with 53 articles being the basis of this review. Multiple risk factors have been suggested in the literature including retroverted uterus in the first trimester, deep sacral concavity with an overlying sacral promontory, endometriosis, previous abdominal or pelvic surgery, pelvic or uterine adhesions, ovarian cysts, leiomyomas, multifetal gestation, uterine anomalies, uterine prolapse, and uterine incarceration in a prior pregnancy...
October 2016: Obstetrical & Gynecological Survey
Huihua Cai, Lin Qiao, KaiJing Song, Yuanli He
STUDY OBJECTIVE: To compare the efficacy of an oxidized, regenerated cellulose adhesion barrier (Interceed, Ethicon Inc., Somerville, NJ, USA) combined with intrauterine device (IUD) versus IUD alone for preventing adhesion recurrence following hysteroscopic adhesiolysis for moderate to severe intrauterine adhesions (IUAs). DESIGN: Retrospective case series (Canadian Task Force classification III). SETTING: Tertiary care teaching hospital...
October 11, 2016: Journal of Minimally Invasive Gynecology
Shinji Yamamoto, Maria Nelander
INTRODUCTION: We present a case report of ectopic pregnancy (EP) after simultaneous pancreas-kidney transplantation (SKPTx). PRESENTATION OF CASE: A 33-year-old female status post SKPTx suddenly got abdominal pain in the lower level. She had high human chorionic Gonadotropin test. Ultrasonography revealed that there was no fetus in the uterus but a dilated right fallopian tube, which strongly suggested ectopic pregnancy. An emergency operation was performed and a dilated right side uterine tube was found with adhesions to her transplant...
September 30, 2016: International Journal of Surgery Case Reports
Pinar Solmaz Hasdemir, Mahmud Ozkut, Tevfik Guvenal, Melis Aylin Uner, Esat Calik, Semra Oruc Koltan, Faik Mumtaz Koyuncu, Kemal Ozbilgin
AIM: To study the efficacy of pirfenidone for prevention of postoperative adhesion formation in an adhesion rat model. MATERIALS AND METHODS: Eighteen female Wistar rats were subjected to right-sided parietal peritoneum and right uterine horn adhesion model. Rats were randomized into three groups: group 1 (control) (closure of midline abdominal incision without any agent administration), group 2 (closure of incision after intraperitoneal administration of pirfenidone), and group 3 (closure of incision and only oral administration of pirfenidone for 14 days)...
August 15, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Natalie K Binder, Jemma Evans, Lois A Salamonsen, David K Gardner, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan
Embryo implantation requires synchronized dialogue between the receptive endometrium and activated blastocyst via locally produced soluble mediators. During the mid-secretory (MS) phase of the menstrual cycle, increased glandular secretion into the uterine lumen provides important mediators that modulate the endometrium and support the conceptus during implantation. Previously we demonstrated the importance of vascular endothelial growth factor (VEGF) in the human uterus, particularly with respect to embryo implantation...
2016: PloS One
L M Kondratovich, A V Kozachenko, L V Adamyan, A A Stepanian
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Yi Zhu, Jianguo Hu, Tinghe Yu, Yan Ren, Lina Hu
BACKGROUND Elevated fibrosis has been found in patients with intrauterine adhesion, which indicates that fibrotic factors may play a critical role in formation of intrauterine adhesion. The aim of this study was to identify the effect of hyaluronic acid (HA) at high and low molecular weight on fibrosis of the endometrium in a mouse model of Asherman's syndrome. MATERIAL AND METHODS Endometrial fibrosis in a mouse model of Asherman's syndrome was confirmed. Then HA at high and low molecular weight was injected into the uterine cavity...
September 27, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jaime Alfaro-Alfaro, María de Los Ángeles Flores-Manzur, Roberto Nevarez-Bernal, Rodrigo Ayala-Yáñez
Laparoscopic myomectomy offers a real benefit to infertile patients with uterine fibroids and peritoneal adhesions. The procedure requires a skilled surgeon and laparoscopy technique to minimize adhesion formation and other proven benefits. Restrictions arise since this procedure requires power morcellation for fibroid tissue extraction. Two years ago, the Food and Drug Administration in the United States of America (FDA) issued the alert on power morcellation for uterine leiomyomas, addressing the risk of malignant cell spreading within the abdominal cavity (actual risk assessment from 1 in 360 to 1 in 7400 cases)...
2016: Case Reports in Obstetrics and Gynecology
Shelly Th McClatchey, Zheng Wang, Lara M Linden, Eric L Hastie, Lin Wang, Wanqing Shen, Alan Chen, Qiuyi Chi, David R Sherwood
Epithelial cells and their underlying basement membranes (BMs) slide along each other to renew epithelia, shape organs, and enlarge BM openings. How BM sliding is controlled, however, is poorly understood. Using genetic and live cell imaging approaches during uterine-vulval attachment in C. elegans, we have discovered that the invasive uterine anchor cell activates Notch signaling in neighboring uterine cells at the boundary of the BM gap through which it invades to promote BM sliding. Through an RNAi screen, we found that Notch activation upregulates expression of ctg-1, which encodes a Sec14-GOLD protein, a member of the Sec14 phosphatidylinositol-transfer protein superfamily that is implicated in vesicle trafficking...
September 23, 2016: ELife
Laura Lindsay, Samson N Dowland, Christopher R Murphy
Controlled ovarian hyperstimulation is an essential component of IVF techniques to ensure proliferation and development of multiple ovarian follicules but the effects of these hormones on the endometrium are largely unknown. During normal pregnancy in rats, there are significant changes in the basal plasma membrane of uterine epithelial cells (UECs) at the time of receptivity, including loss of focal adhesions. This enables the UECs to be removed from the implantation chamber surrounding the blastocyst, thus allowing invasion into the underlying stroma...
September 20, 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
Gülçin Saltan, Ipek Süntar, Serkan Ozbilgin, Mert Ilhan, M Ayşe Demirel, Burçin Ergene Oz, Hikmet Keleş, Esra Küpeli Akkol
ETHNOPHARMACOLOGICAL RELEVANCE: Endometriosis is a gynecological disorder characterized by the presence of endometrial tissue outside the uterine cavity. The fruits of Viburnum opulus L. have been used to treat gynecological disorders including primary and secondary dysmenorrhea and ovarian cysts. MATERIALS AND METHODS: Air-dried and powdered fruits of V. opulus were extracted sequentially with n-hexane, ethyl acetate (EtOAc), and methanol (MeOH), respectively for four days...
September 16, 2016: Journal of Ethnopharmacology
Mana Iida, Hiroshi Ishikawa, Makio Shozu
We report a case of spontaneous parasitic leiomyoma in a 30-year-old post-partum woman. A subserosal leiomyoma had been noted at the first trimester screening, and she had experienced persistent abdominal pain during her previous pregnancy. She was referred to hospital with severe abdominal pain at 7 months after delivery. We detected a homogenous solid tumor that resembled the subserosal leiomyoma but was completely detached from the uterus. On laparoscopy the vascularization of the tumor was supplied from the omentum, which was tightly adherent to the tumor...
September 19, 2016: Journal of Obstetrics and Gynaecology Research
Jan Tesarik, Raquel Mendoza-Tesarik, Nicolas Mendoza
No abstract text is available yet for this article.
September 15, 2016: American Journal of Obstetrics and Gynecology
Margarita V Revzin, Mahan Mathur, Haatal B Dave, Matthew L Macer, Michael Spektor
Pelvic inflammatory disease (PID) is a common medical problem, with almost 1 million cases diagnosed annually. Historically, PID has been a clinical diagnosis supplemented with the findings from ultrasonography (US) or magnetic resonance (MR) imaging. However, the diagnosis of PID can be challenging because the clinical manifestations may mimic those of other pelvic and abdominal processes. Given the nonspecific clinical manifestations, computed tomography (CT) is commonly the first imaging examination performed...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Nicole Ziegler, Matthias Korell, Anja Herrmann, Maya Sophie de Wilde, Luz Angela Torres-de la Roche, Angelika Larbig, Rudy Leon De Wilde
BACKGROUND: Uterine perforation is the most common complication of curettage and may result in bleeding. Therefore, urgent control of bleeding from the uterine wall perforation is necessary to avoid an emergency hysterectomy or blood transfusion, to prevent peritoneal adhesion formation, possible chronic pelvic pain, and infertility. In the present case, an active bleeding secondary to a perforation of the uterus during curettage, for diagnosis of endometrial carcinoma, was instantaneously and successfully treated with only the application of a novel modified polysaccharide powder...
2016: Journal of Medical Case Reports
Emma Marchionatti, Sylvain Nichols, Marie Babkine, Hélène Lardé, Réjean Lefebvre, André Desrochers
OBJECTIVE: To describe the clinical findings, surgical treatment, and long-term outcome of dairy cattle undergoing partial hysterectomy with or without unilateral ovariectomy. STUDY DESIGN: Retrospective case series. ANIMALS: Dairy cattle (n = 7). METHODS: Medical records (June 2007-June 2014) of dairy cattle that had partial hysterectomy with or without ipsilateral ovariectomy were reviewed. Follow-up data were obtained by telephone interviews with owners and referring veterinarians between 6 months and 7 years following discharge...
October 2016: Veterinary Surgery: VS
Mehmet Ozgur Akkurt, And Yavuz, Serenat Eris Yalcin, Iltac Akkurt, Ozerk Turel Turan, Yakup Yalcin, Mekin Sezik
AIM: To investigate short- and long-term outcomes in women undergoing cesarean myomectomy (CM) Methods: This was a retrospective study that explored short-term outcomes of women, who underwent cesarean operations with or without myomectomies (CM controls) in a single tertiary centre throughout a 6-year-period. For long-term outcomes, the mean duration of follow-up was 6.3 ± 1.0 years. RESULTS: There were no differences among the CM (n= 91) and control groups (n = 60) considering mean change in hemoglobin and hematocrit levels, hemorrhage, as well as requirement for blood transfusions with a slightly increased operative time...
August 23, 2016: Journal of Maternal-fetal & Neonatal Medicine
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