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Uterine adhesions

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https://www.readbyqxmd.com/read/29233171/deep-infiltrating-ureteral-endometriosis-with-catamenial-hydroureteronephrosis-a-case-report
#1
Hyun Jung Lee, Yoon Soon Lee
BACKGROUND: This aim of this case report is to raise awareness of ureteral endometriosis in women of reproductive age with hydronephrosis in the absence of urolithiasis to enable early diagnosis and prevent loss of renal function. CASE PRESENTATION: A 44-year-old Asian woman presented with a 4-year history of cyclic right flank pain and right hydronephrosis during menstruation. Despite several evaluations by physicians, including gynecologists, the cause of her symptoms was not diagnosed...
December 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29221993/accuracy-of-tubal-patency-assessment-in-diagnostic-hysteroscopy-compared-to-laparoscopy-in-infertile-women-a-retrospective-cohort-study
#2
Regina Promberger, Inga-Malin Simek, Kazem Nouri, Karin Obermaier, Christine Kurz, Johannes Ott
STUDY OBJECTIVE: To evaluate whether the presence of a visualizable "flow" effect in the Fallopian tube ostia in hysteroscopic routine evaluation is predictive of tube patency. DESIGN: Retrospective cohort study (Canadian Task Force Classification II-2) SETTING: Data from all patients who underwent surgery due to infertility at the study center between 2008 and 2016 was analyzed retrospectively. The main outcome parameter was Fallopian tube patency as assessed by laparoscopic chromopertubation...
December 5, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29216626/evidence-for-hmgn2-involvement-in-mouse-embryo-implantation-and-decidualization
#3
Dang-Dang Li, Liang Yue, Zhan-Qing Yang, Lian-Wen Zheng, Bin Guo
BACKGROUND/AIMS: Hmgn2 is involved in regulating embryonic development, but its physiological function during embryo implantation and decidualization remains unknown. METHODS: In situ hybridization, real-time PCR, RNA interference, gene overexpression and MTS assay were used to examine the expression of Hmgn2 in mouse uterus during the pre-implantation period and explore its function and regulatory mechanisms in epithelial adhesion junction and stromal cell proliferation and differentiation...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29210631/uterine-function-from-normal-to-polycystic-ovarian-syndrome-alterations
#4
Silvana Rocio Ferreira, Alicia Beatriz Motta
BACKGROUND: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. METHODS: We conducted a search at the http://www.ncbi.nlm.nhi.gov/pubmed/electronic database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29208873/correlation-between-seropositivity-of-chlamydia-trachomatis-and-tubal-and-or-pelvic-pathology-detected-by-diagnostic-laparoscopy-in-subfertile-women
#5
N Begum, S A Anwary, M Alfazzaman, Z Mahzabin, F Deeba, M A Mostafa, M Akhter, M M Rahman
This prospective observational study was carried out in the Infertility Unit, Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from February 2011 to December 2013. Sixty-nine (69) subfertile women who were seropositive for Chlamydia Trachomatis were included in this study. Inclusion criteria was patients with sub-fertility having age between 22 and 40 years, seeking infertility treatment, normal ovarian function, all normozoospermic male partner, duration of infertility ranged from 1...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29202724/epcam-expression-in-squamous-cell-carcinoma-of-the-uterine-cervix-detected-by-monoclonal-antibody-to-the-membrane-proximal-part-of-epcam
#6
Warangkana Chantima, Charin Thepthai, Pornsuk Cheunsuchon, Tararaj Dharakul
BACKGROUND: Epithelial cell adhesion molecule (EpCAM) is a promising biomarker for squamous cell carcinoma (SCC) of the uterine cervix, because it is over-expressed in various cancers of epithelial origin. However, EpCAM expression reported in previous immunohistochemistry (IHC) studies was inconsistent. We hypothesize that the membrane-distal part of EpCAM may be lost during tissue preparation, leaving only the membrane-proximal part of EpCAM available for antibody binding and IHC staining...
December 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29196267/intrauterine-exosomes-are-required-for-bovine-conceptus-implantation
#7
Kazuya Kusama, Keigo Nakamura, Rulan Bai, Kentaro Nagaoka, Toshihiro Sakurai, Kazuhiko Imakawa
Exosomes, extracellular vesicles, are present in uterine flushing fluids (UFs), which are involved in conceptus-endometrial interactions during peri-implantation periods. Despite several studies on intrauterine exosomes conducted, the roles conceptus and endometrial exosomes play during peri-implantation periods have not been well characterized. To investigate the effect of bovine intrauterine exosomes on conceptus implantation, exosomes isolated from bovine UFs during peri-implantation periods were subjected to global protein analysis...
November 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29184870/a-retroperitoneal-dedifferentiated-liposarcoma-mimicking-an-ovarian-tumor
#8
Hyojin Kim, Taewon Jeong, Yeongho Lee, Gyeonga Kim, Sanggi Hong, Sukyung Beck, Jeongbeom Mun, Kyongjin Kim, Myeongjin Ju
A 74-year-old postmenopausal woman visited our gynecology clinic complaining of a palpable abdominal mass. Physical and radiological evaluation indicated that the mass exhibited features of a left ovarian neoplasm showing heterogeneous enhancement. Surgical resection was performed to confirm this suspicion. During surgery, a mass was observed only in the left ovary with no invasive growth, but adhesions to the surrounding peritoneum were seen. Given the patient's age, large mass size, and accompanying uterine myoma and right ovarian cyst, total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29181164/recent-findings-on-epigenetic-gene-abnormalities-involved-in-uterine-cancer
#9
Megumi Yanokura, Kouji Banno, Yusuke Kobayashi, Hiroyuki Nomura, Shigenori Hayashi, Eiichiro Tominaga, Daisuke Aoki
Selective aberrant genetic effects that do not depend on abnormal DNA sequences are referred to as epigenetic abnormalities and are involved in carcinogenesis. In uterine cancer, various genes involved in apoptosis, cell cycle, DNA repair, cell proliferation and cell adhesion are abnormally methylated, resulting in gene silencing. Reversal of such epigenetic abnormalities in cancer cells is a potential strategy for cancer therapy, and studies on epigenetic abnormalities and treatment methods in uterine cancer are in progress...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29157289/vitamin-c-plus-hydrogel-facilitates-bone-marrow-stromal-cell-mediated-endometrium-regeneration-in-rats
#10
Huan Yang, Su Wu, Ran Feng, Junjiu Huang, Lixiang Liu, Feng Liu, Yuqing Chen
BACKGROUND: Intrauterine adhesion (IUA) is a common uterine cavity disease which can be caused by mechanical damage that may eventually lead to infertility and pregnancy abnormalities. Since the effect of therapeutic drugs appears disappointing, cell therapy has emerged as an alternative choice for endometrium regeneration. The aim of this study is to investigate whether the combination of hydrogel Pluronic F-127 (PF-127), Vitamin C (Vc), and a bone marrow stromal cell (BMSC) mixture could be a feasible strategy to improve the endometrial regeneration in a mechanical damage model of IUA in rats...
November 21, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29146391/small-diameter-hysteroscopic-metroplasty-for-a-septate-uterus-after-open-assisted-laparoscopic-radical-trachelectomy
#11
Akimasa Takahashi, Hiroyuki Kanao, Nobuhiro Takeshima
STUDY OBJECTIVE: To describe a two-step fertility preservation technique for early-stage cervical cancer of a patient with a complete septate uterus. DESIGN: A step-by-step demonstration and explanation of the technique in a surgical video (Canadian Task Force Classification III). SETTING: Center for cancer, a tertiary referral center. The patient provided informed consent to use images and videos of the procedure. Institutional Review Board approval was not required for this kind of procedure...
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29136193/early-first-trimester-uteroplacental-flow-and-the-progressive-disintegration-of-spiral-artery-plugs-new-insights-from-contrast-enhanced-ultrasound-and-tissue-histopathology
#12
V H J Roberts, T K Morgan, P Bednarek, M Morita, G J Burton, J O Lo, A E Frias
STUDY QUESTION: Does the use of a vascular contrast agent facilitate earlier detection of maternal flow to the placental intervillous space (IVS) in the first trimester of pregnancy? SUMMARY ANSWER: Microvascular filling of the IVS was demonstrated by contrast-enhanced ultrasound from 6 weeks of gestation onwards, earlier than previously believed. WHAT IS KNOWN ALREADY: During placental establishment and remodeling of maternal spiral arteries, endovascular trophoblast cells invade and accumulate in the lumen of these vessels to form 'trophoblast plugs'...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29133151/laparoscopic-management-of-a-rudimentary-uterine-horn
#13
Emilie Faller, Jean Jacques Baldauf, François Becmeur, Anne Lehn, Cherif Youssef Akladios, Lise Lecointre
STUDY OBJECTIVE: To demonstrate a technique of laparoscopic management of a rudimentary horn in a 12-year-old girl. DESIGN: A step-by-step explanation of the surgery using video (instructive video), approved the local institutional Review Board. SETTING: A university hospital, University Hospital of Strasbourg, France. PATIENT: A 12-year-old girl with a uterine rudimentary horn. INTERVENTION: We describe the case of a 12 years old girl who had no medical history...
November 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29129378/transvaginal-natural-orifice-transluminal-endoscopic-surgery-a%C3%A2-new-approach-to-myomectomy
#14
Jan Baekelandt
OBJECTIVE: To demonstrate a new approach for performing a myomectomy via transvaginal natural-orifice transluminal endoscopic surgery (vNOTES) as an alternative to laparoscopic myomectomy. DESIGN: Stepwise explanation of the technique with the use of original video footage. SETTING: Hospital. PATIENT(S): Eight patients were treated transvaginally for intramural, subserosal, and pedunculated myomas. INTERVENTION(S): In case of a posterior myoma, a 2...
November 9, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29113580/prominin-2-prevents-the-formation-of-caveolae-in-normal-and-ovarian-hyperstimulated-pregnancy
#15
Samson N Dowland, Romanthi J Madawala, Connie E Poon, Laura A Lindsay, Christopher R Murphy
During early pregnancy, uterine epithelial cells (UECs) become less adherent to the underlying basal lamina and are subsequently removed so the blastocyst can invade the underlying stroma. This process involves the removal of focal adhesions from the basal plasma membrane of UECs. These focal adhesions are thought to be internalized by caveolae, which significantly increase in abundance at the time of blastocyst implantation. A recent in vitro study indicated that prominin-2 prevents the formation of caveolae by sequestering membrane cholesterol...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29104078/eucalyptus-robusta-leaves-methanolic-extract-suppresses-inflammatory-mediators-by-specifically-targeting-tlr4-tlr9-mpo-cox2-inos-and-inflammatory-cytokines-in-experimentally-induced-endometritis-in-rats
#16
Aastha Tiwari, Preeti Singh, Pooja Jaitley, Sushant Sharma, Atul Prakash, Rajesh Mandil, Soumen Choudhury, Neeraj Kumar Gangwar, Satish K Garg
ETHNOPHARMACOLOGICAL RELEVANCE: Bacterial endometritis is one of the major causes of reproductive disorders including infertility in farm animals. Antibiotics are generally used for treatment of such disorders but now a days residues of antibiotics are of great public health concern, therefore, phytoremediation is being considered as an alternative to use of antibiotics. AIM OF THE STUDY: Present study was undertaken to investigate the efficacy of Eucalyptus robusta leaves methanolic extract against endometritis along with the possible mechanism of action especially targeting inflammatory biomarkers...
November 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29096548/thermosensitive-hydrogels-a-versatile-concept-adapted-to-vaginal-drug-delivery
#17
Sebastien Taurin, Aliyah A Almomen, Tatianna Pollak, Sun Jin Kim, John Maxwell, C Matthew Peterson, Shawn C Owen, Margit M Janát-Amsbury
Vaginal drug delivery represents an attractive strategy for local and systemic delivery of drugs otherwise poorly absorbed after oral administration. The rather dense vascular network, mucus permeability and the physiological phenomenon of the uterine first-pass effect can all be exploited for therapeutic benefit. However, several physiological factors such as an acidic pH, constant secretion, and turnover of mucus as well as varying thickness of the vaginal epithelium can impact sustained drug delivery. In recent years, polymers have been designed to tackle challenges mentioned above...
November 3, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29040564/n-cadherin-identifies-human-endometrial-epithelial-progenitor-cells-by-in-vitro-stem-cell-assays
#18
Hong P T Nguyen, L Xiao, James A Deane, Ker-Sin Tan, Fiona L Cousins, Hirotaka Masuda, Carl N Sprung, Anna Rosamilia, Caroline E Gargett
STUDY QUESTION: Is there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity using in vitro assays? SUMMARY ANSWER: N-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structures in vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29038040/hysteroscopic-intrauterine-adhesiolysis-using-a-blunt-spreading-dissection-technique-with-a-double-action-forceps
#19
Huan Huang, Chunxia Cheng, Grace Johnson, Ruoyi Wang, Min Xue, Aiqian Zhang, Dabao Xu, Xiaoming Guan
STUDY OBJECTIVE: To demonstrate step by step the technique of hysteroscopic adhesiolysis (HA) by means of a blunt spreading technique using double action forceps to dissect and restore the layer between the anterior and posterior uterine walls in a patient with severe intrauterine adhesions (IUA), particularly in cases in which the endometrial lining is obscured on ultrasound imaging and the endometrial cavity is completely occluded on hysteroscopy. DESIGN: Step-by-step explanation of the technique using videos and pictures (educative video) (Canadian Task Force Classification III)...
October 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29036173/pre-treatment-with-gnrha-or-ulipristal-acetate-prior-to-laparoscopic-and-laparotomic-myomectomy-a-systematic-review-and-meta-analysis
#20
REVIEW
Inge de Milliano, Moniek Twisk, Johannes C Ket, Judith A Huirne, Wouter J Hehenkamp
BACKGROUND: Myomectomy has potential risks of complications. To reduce these risks, medical pre-treatment can be applied to reduce fibroid size and thereby potentially decrease intra-operative blood loss, the need for blood transfusion and emergency hysterectomy. The aim of this systematic review and meta-analysis is to study the effectiveness of medical pre-treatment with Gonadotropin-releasing hormone agonists (GnRHa) or ulipristal acetate prior to laparoscopic or laparotomic myomectomy on intra-operative and post-operative outcomes...
2017: PloS One
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