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Uterine adhesions

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https://www.readbyqxmd.com/read/29611773/effect-of-surgical-adhesive-on-the-uterus-of-rabbits-following-occlusion
#1
Anran Xu, Tianyu Hao, Xiaoqing Wei, Chuanfen Li, Lihua Niu, Xiaohui Deng
Purpose/Aim of the Study: The present study investigated the effect of surgical adhesives on the uterus of rabbits and the histomorphology alterations following occlusion, to improve the clinical treatment of abnormal fallopian tube with surgical adhesives for in vitro fertilization and embryo transfer (IVF-ET). MATERIALS AND METHODS: The experimental rabbits received laparotomy and occlusion of the uterus by surgical adhesive adjacent to the two fallopian tubes, while the control rabbits only received laparotomy...
April 3, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29575202/sonographic-evaluation-of-intra-abdominal-adhesions-during-the-third-trimester-of-pregnancy-a-novel-technique-in-women-undergoing-repeated-cesarean-section
#2
Joel Baron, Dan Tirosh, Salvatore Andrea Mastrolia, Yigal Ben-Haroush, Shoshana Schwartz, Yoav Kerner, Reli Hershkovitz
OBJECTIVES: Intra-abdominal adhesions may result in an increased risk of major complications in case of a repeated cesarean section, such as bladder and bowel injury, hemorrhage, infection, and hysterectomy. In an attempt to predict intra-abdominal adhesions before a repeated cesarean delivery, we suggest the use of a novel technique employing a simple and feasible ultrasound imaging technique. METHODS: The study included pregnant women who underwent one or more cesarean deliveries in their obstetric history and were evaluated during the third trimester of the ongoing pregnancy...
March 25, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29571018/stem-cell-therapy-in-asherman-syndrome-and-thin-endometrium-stem-cell-based-therapy
#3
REVIEW
Ramyar Azizi, Leili Aghebati-Maleki, Mohammad Nouri, Faroogh Marofi, Sohrab Negargar, Mehdi Yousefi
The endometrium is one of the essential components of the uterus. The endometrium of human is a complex and dynamic tissue, which undergoes periods of growth and turn over during any menstrual cycle. Stem cells are initially undifferentiated cells that display a wide range of differentiation potential with no distinct morphological features. Stem cell therapy method recently has become a novel procedure for treatment of tissue injury and fibrosis in response to damage. Currently, there is massive interest in stem cells as a novel treatment method for regenerative medicine and more specifically for the regeneration of human endometrium disorder like Asherman syndrome (AS) and thin endometrium...
March 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29568968/screening-of-potential-biomarkers-in-uterine-leiomyomas-disease-via-gene-expression-profiling-analysis
#4
Xuhui Liu, Yanfei Liu, Jingrong Zhao, Yan Liu
The present study aimed to screen potential biomarkers for uterine leiomyomas disease, particularly target genes associated with the mediator of RNA polymerase II transcription subunit 12 (MED12) mutation. The microarray data of GSE30673, including 10 MED12 wild-type myometrium, 8 MED12 mutation leiomyoma and 2 MED12 wild-type leiomyoma samples, were downloaded from the Gene Expression Omnibus database. Compared with myometrium samples, differently-expressed genes (DEGs) in the MED12 mutation and wild-type leiomyoma samples were identified using the Limma package...
March 15, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29554266/integration-of-molecules-to-construct-the-processes-of-conceptus-implantation-to-the-maternal-endometrium
#5
K Imakawa, R Bai, K Kusama
During the peri-implantation period, ruminant conceptuses go through rapid elongation, followed by their attachment to the uterine endometrial epithelial cells, during which interferon-tau (IFNT), a trophectodermal cytokine required for the process of maternal recognition of pregnancy, is expressed in a temporal and spatial manner. On d 22 (d 0 = day of estrus), 2 to 3 d after the initiation of bovine conceptus attachment to the uterine epithelium, when IFNT production begins to subside, the expression of molecules related to epithelial-mesenchymal transition, zinc finger E-box binding homeobox 1, snail family transcriptional repressor 2, N-cadherin and vimentin was found in the trophectoderm...
March 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29520860/antiadipogenic-effects-of-a-standardized-quassinoids-enriched-fraction-and-eurycomanone-from-eurycoma-longifolia
#6
D Balan, Kit-Lam Chan, D Murugan, Sazaly AbuBakar, Pooi-Fong Wong
Bioactive compounds of Eurycoma longifolia (EL) jack were previously shown to reduce omentum fat mass and oestradiol-induced fatty uterine adhesion in rats. However, the exact role of EL on adipogenesis remains unknown. This study sought to investigate the effects of an EL standardized quassinoids-enriched fraction (SQEL) and the pure compound, eurycomanone, on adipogenesis in 3T3-L1 preadipocyte cells. 3T3-L1 cells were induced to differentiate and treated for 8 days. The treatment reduced intracellular accumulation of lipid droplets and triglycerides in the differentiating adipocytes and induced lipolysis in matured adipocytes...
March 9, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29512784/transdermal-estrogen-gel-and-oral-aspirin-combination-therapy-improves-fertility-prognosis-via-the-promotion-of-endometrial-receptivity-in-moderate-to-severe-intrauterine-adhesion
#7
Yugang Chi, Ping He, Li Lei, Yi Lan, Jianguo Hu, Ying Meng, Lina Hu
Intrauterine adhesion (IUA) is one of the most common gynecological diseases in women of reproductive age. IUA, particularlyin moderate to severe forms, accounts for a large percentage of infertility cases. Clinically, the first‑line treatment strategy for IUA is transcervical resection of adhesion (TCRA), followed by adjuvant postoperative treatment. Estrogen is one of the classic chemotherapies used following TCRA and contributes to preventing re‑adhesion following surgery. However, estrogen has limited effects in promoting pregnancy, which is the ultimate goal for IUA management...
March 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29510965/-minimal-and-mild-endometriosis-impact-of-the-laparoscopic-surgery-on-pelvic-pain-and-fertility-cngof-has-endometriosis-guidelines
#8
S Ploteau, B Merlot, H Roman, M Canis, P Collinet, X Fritel
Minimal and mild endometriosis (stage 1 and 2 AFSR) can lead to chronic pelvic pain and infertility but can also exist in asymptomatic patients. The prevalence of asymptomatic patients with minimal and mild endometriosis is not clear but typical endometriosis lesions are found in about 5 to 10% of asymptomatic women and more than 50% of painful and/or infertile women. Laparoscopic treatment of minimal and mild endometriotic lesions is justified in case of pelvic pain because their destruction decrease significatively the pain compared with diagnostic laparoscopy alone...
March 3, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29510641/-intravenous-leiomyomatosis-as-a-rare-tumor-of-myometrium
#9
V Regász, V Boháč, J Rychnovský
AIM: To present a case of a woman diagnosed with intravenous leiomyomatosis of the uterus. TYPE OF STUDY: Case report. SETTING: Department of Obstetrics & Gynaecology, Středomoravská nemocniční a.s., Přerov Hospital. CASE REPORT: A 39-year old woman was referred to our unit with uterine fibroids, dysfunctional uterine bleeding and anaemia. Abdominal hysterectomy was performed. The histopathological analysis diagnosed the presence of intravenous leiomyomatosis...
2018: Ceská Gynekologie
https://www.readbyqxmd.com/read/29500127/pelvic-chlamydial-infection-predisposes-to-ectopic-pregnancy-by-upregulating-integrin-%C3%AE-1-to-promote-embryo-tubal-attachment
#10
Syed F Ahmad, Jeremy K Brown, Lisa L Campbell, Magda Koscielniak, Catriona Oliver, Nick Wheelhouse, Gary Entrican, Stuart McFee, Gillian S Wills, Myra O McClure, Patrick J Horner, Sevasti Gaikoumelou, Kai F Lee, Hilary O D Critchley, W Colin Duncan, Andrew W Horne
Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is unclear. Successful intra-uterine embryo implantation is associated with increased expression of endometrial "receptivity" integrins (cell adhesion molecules). We examined integrin expression in Fallopian tubes of women with previous C. trachomatis infection, in mice experimentally infected with C...
February 23, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29483785/the-effect-of-endometrial-thickness-on-pregnancy-outcome-in-patients-with-asherman-s-syndrome-post-hysteroscopic-adhesiolysis
#11
Saeed Baradwan, Dina Shafi, Amira Baradwan, Muhammad Salman Bashir, Dania Al-Jaroudi
Background: Hysteroscopic adhesiolysis anatomically restores the uterine cavity in cases of Asherman's syndrome (AS); however, the extent of endometrial fibrosis could determine the pregnancy outcome. Objectives: To determine whether endometrial thickness could influence pregnancy outcome of hysteroscopic adhesiolysis in women with a history of AS. Subjects and methods: This was a retrospective cohort study that included 41 women who attended Women's Specialized Hospital, King Fahad Medical City from December 2008 to December 2015, presented with a history of infertility or recurrent pregnancy loss, and were diagnosed with intrauterine adhesions and treated by hysteroscopic adhesiolysis...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29471449/obesity-associated-advanced-glycation-end-products-within-the-human-uterine-cavity-adversely-impact-endometrial-function-and-embryo-implantation-competence
#12
Gabriella S Antoniotti, Melinda Coughlan, Lois A Salamonsen, Jemma Evans
STUDY QUESTION: Do obese levels of advanced glycation end products (AGEs) within the uterine cavity detrimentally alter tissue function in embryo implantation and placental development? SUMMARY ANSWER: Obese levels of AGEs activate inflammatory signaling (p65 NFκB) within endometrial epithelial cells and alter their function, cause endoplasmic reticulum (ER) stress in endometrial stromal cells and impair decidualization, compromise implantation of blastocyst mimics and inhibit trophoblast invasion...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29462279/mechanisms-for-the-establishment-and-maintenance-of-pregnancy-synergies-from-scientific-collaborations
#13
Fuller W Bazer, Robert C Burghardt, Gregory A Johnson, Thomas E Spencer, Guoyao Wu
Research on the functions of interferon tau (IFNT) at Texas A&M University led to the theory of pregnancy recognition signaling in ruminant species. But, IFNT does much more as it induces expression of interferon regulatory factor 2 (IRF2) in uterine luminal (LE), superficial glandular (sGE), but not glandular (GE) epithelia. First, IRF2 silences transcription of the estrogen receptor alpha gene and, indirectly, transcription of the oxytocin receptor gene to abrogate development of the luteolytic mechanism to prevent regression of the corpus luteum and its production of progesterone for establishing and maintaining pregnancy...
February 16, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29454580/are-synechiae-a-complication-of-laparotomic-myomectomy
#14
Perrine Capmas, Anne-Gaelle Pourcelot, Hervé Fernandez
Laparotomic myomectomy is often the only realistic solution for symptomatic women with multiple or large myomas who wish to retain their fertility. The aim of this study was to document the rate of uterine synechiae and their associated risk factors after laparotomic myomectomy. This prospective observational study took place in a teaching hospital from May 2009 to June 2014. It included all women aged 18-45 years who had laparotomic myomectomies (without diagnostic hysteroscopy at the time of surgery) for myomas and a postoperative diagnostic office hysteroscopy 6-8 weeks later...
February 2, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29447856/laparoscopic-sacrohysteropexy-in-a-woman-at-12-weeks-gestation
#15
Berna Haliloglu Peker, Erdin Ilter, Hakan Peker, Aygen Celik, Ali Gursoy, Onur Gunaldi
STUDY OBJECTIVE: To demonstrate laparoscopic sacrohysteropexy for a case of uterine prolapse in a 12 weeks, 3 days pregnant woman. To our knowledge this is the first case of laparoscopic sacrohysteropexy performed at 12 weeks of gestation to be reported in literature. DESIGN: A step-by-step explanation of the surgical procedure (Canadian Task Force classification III). SETTING: Maltepe University Hospital. PATIENT: A 37-year-old pregnant woman...
February 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29439094/uterine-and-placental-distribution-of-selected-extracellular-matrix-ecm-components-in-the-dog
#16
Felix R Graubner, Alois Boos, Selim Aslan, Ibrahim Kücükaslan, Mariusz P Kowalewski
For many years, modifications of the uterine extracellular matrix (ECM) during gestation have not been considered as critical for successful canine (Canis lupus familiaris) pregnancy. However previous reports indicated an effect of free-floating blastocysts on the composition of the uterine ECM. Here, the expression of selected genes involved in structural functions, cell-to-cell communication and inhibition of matrix metalloproteinases were targeted utilizing qPCR and immunohistochemistry. We found that canine free-floating embryos affect gene expression of FN1, ECM1 and TIMP4...
February 9, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29433563/therapeutic-effect-of-human-umbilical-cord-derived-mesenchymal-stem-cells-on-injured-rat-endometrium-during-its-chronic-phase
#17
Lu Zhang, Ying Li, Chun-Yi Guan, Shi Tian, Xiao-Dan Lv, Jian-Hui Li, Xu Ma, Hong-Fei Xia
BACKGROUND: Repair deficiency after endometrial injury is an important reason for intra-uterine adhesions, amenorrhea, and infertility in females. Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is effective in repairing the damaged endometrium. However, the possibility of using umbilical cord-derived MSCs (UC-MSCs) to treat endometrial injury is rarely reported. METHODS: Ethanol (95%) was injected into rat uterus to establish a model of endometrial injury...
February 13, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29432175/uterine-influences-on-conceptus-development-in-fertility-classified-animals
#18
Joao G N Moraes, Susanta K Behura, Thomas W Geary, Peter J Hansen, Holly L Neibergs, Thomas E Spencer
A major unresolved issue is how the uterus influences infertility and subfertility in cattle. Serial embryo transfer was previously used to classify heifers as high-fertile (HF), subfertile (SF), or infertile (IF). To assess pregnancy loss, two in vivo-produced embryos were transferred into HF, SF, and IF heifers on day 7, and pregnancy outcome was assessed on day 17. Pregnancy rate was substantially higher in HF (71%) and SF (90%) than IF (20%) heifers. Elongating conceptuses were about twofold longer in HF than SF heifers...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29420398/sliding-sign-for-intra-abdominal-adhesion-prediction-before-repeat-cesarean-delivery
#19
Lior Drukker, Hen Y Sela, Orna Reichman, Ron Rabinowitz, Arnon Samueloff, Ori Shen
BACKGROUND: The sliding sign (the relative motion between the abdominal and uterine wall as assessed by ultrasonography) may help identify severe intra-abdominal adhesions before repeat cesarean delivery. METHODS: We conducted a prospective observational study of scheduled repeat cesarean deliveries. Using transabdominal ultrasonography, while the parturient breathed deeply, the ultrasonographer recorded a video clip in a sagittal plane lateral to the umbilicus...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29416572/etiology-of-cesarean-uterine-scar-defect-niche-detailed-critical-analysis-of-hypotheses-and-prevention-strategies-and-peritoneal-closure-debate
#20
REVIEW
Shashikant L Sholapurkar
There is an increasing incidence of cesarean scar (CS) defect/niche and its sequelae, probably not entirely explained by better diagnosis or rising cesarean rate. Discussion of possible etiological factors has received scant attention but would be important to formulate preventive strategies. Meaningful informative studies on long-term sequelae of cesarean section are very difficult and none are available for causation of CS defect. Hence, it is crucial to identify key areas in etiology of CS defect for focused research...
March 2018: Journal of Clinical Medicine Research
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