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Uterine adhesions

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https://www.readbyqxmd.com/read/28105226/expression-of-epidermal-growth-factor-like-domain-7-may-be-a-predictive-marker-of-the-effect-of-neoadjuvant-chemotherapy-for-locally-advanced-uterine-cervical-cancer
#1
Makoto Yamauchi, Takeshi Fukuda, Takuma Wada, Masaru Kawanishi, Kenji Imai, Reiko Tasaka, Tomoyo Yasui, Toshiyuki Sumi
Neoadjuvant chemotherapy (NAC) followed by hysterectomy may be effective for the treatment of locally advanced uterine cervical cancer and improve patient prognosis. It is important to identify markers that are able to predict whether NAC may be successful. Epidermal growth factor-like domain 7 (EGFL7) regulates vascular sprouting in blood vessel formation. In numerous types of human cancer, EGFL7 is upregulated and inhibits endothelial cell adhesion molecules, decreasing vascular tightness and, thus, increasing vascular permeability...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28058144/failed-mask-ventilation-due-to-air-leakage-around-the-orbit-in-a-patient-with-a-history-of-radical-maxillofacial-surgery-with-orbital-exenteration
#2
Reiko Horishita, Kenji Kayashima
A 72-year-old male (height: 160 cm, weight: 53 kg) was scheduled to undergo left renal and male with ans uterine tract resection. The patient had previously undergone right radical maxillofacial surgery with orbital exenteration 14 years before the present operation to treat squamous cell carcinoma of the right maxillary sinus, with tumour invasion to the orbital floor. An anaesthesiologist encountered difficulty in performing mask ventilation during the induction of anaesthesia in the patient, despite a good mask fit on the face, because the adhesive tape around the orbit had moved...
December 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28050333/placenta-percreta-and-incomplete-uterine-rupture-after-endometrial-ablation-and-tubal-occlusion
#3
Jaden R Kohn, Edwina Popek, Concepcion R Diaz-Arrastia, Xiaoming Guan, Alireza A Shamshirsaz, Michael A Belfort, Karin A Fox
Endometrial ablation offers symptomatic relief for menorrhagia. Pregnancy after ablation is rare but is often complicated due to pregnancy loss, growth restriction, preterm premature rupture of membranes, preterm delivery, and morbidly adherent placentation, a dangerous complication that can result in hemorrhage, intensive care unit admission, and cesarean hysterectomy. We report a case of pregnancy conceived contemporaneously with endometrial ablation and tubal occlusion. Diagnosis of pregnancy was delayed due to low suspicion...
October 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28043966/embryo-epithelium-interactions-during-implantation-at-a-glance
#4
REVIEW
John D Aplin, Peter T Ruane
At implantation, with the acquisition of a receptive phenotype in the uterine epithelium, an initial tenuous attachment of embryonic trophectoderm initiates reorganisation of epithelial polarity to enable stable embryo attachment and the differentiation of invasive trophoblasts. In this Cell Science at a Glance article, we describe cellular and molecular events during the epithelial phase of implantation in rodent, drawing on morphological studies both in vivo and in vitro, and genetic models. Evidence is emerging for a repertoire of transcription factors downstream of the master steroidal regulators estrogen and progesterone that coordinate alterations in epithelial polarity, delivery of signals to the stroma and epithelial cell death or displacement...
January 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28034338/bioengineering-strategies-to-treat-female-infertility
#5
Che-Ying Kuo, Hannah B Baker, Melissa H Fries, James J Yoo, Peter Cw Kim, John P Fisher
Bioengineering strategies have demonstrated enormous potential to treat female infertility as a result of chemotherapy, uterine injuries, fallopian tube occlusion, massive intrauterine adhesions, congenital uterine malformations and hysterectomy. These strategies can be classified into two broad categories: 1) Transplantation of fresh or cryopreserved organs into the host; and 2) tissue engineering approaches that utilize a combination of cells, growth factors and biomaterials that leverages the body's inherent ability to regenerate/repair reproductive organs...
December 30, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27998942/integrins-functioning-in-uterine-endometrial-stromal-and-epithelial-cells-in-estrus
#6
Hye Jin Park, Ji Eun Park, Hyun Lee, Seong Jae Kim, Jung Im Yun, Minseok Kim, Kyu Hyun Park, Seung Tae Lee
Here, as a basic study in the construction of a non-cellular niche that supports artificial organization of three-dimensional endometrial tissue, we defined the types of integrin heterodimers that are expressed transcriptionally, translationally and functionally in endometrial stromal (ES) and endometrial epithelial (EE) cells isolated from the mouse uterus in estrus. Gene and protein expression of integrin subunits were analyzed at the transcriptional and translational level by real-time PCR and fluorescent immunoassay, respectively...
March 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27997081/uterine-focal-adhesion-dynamics-during-pregnancy-in-a-marsupial-sminthopsis-crassicaudata-dasyuridae
#7
Melanie K Laird, Michaela Turancova, Bronwyn M McAllan, Christopher R Murphy, Michael B Thompson
Alterations to the basal attachment points between the epithelium of the uterus and the underlying tissue in early pregnancy affect how easily the epithelium can be invaded by the implanting embryo. Attachment points- focal adhesions- disassemble to facilitate highly invasive implantation in rats, but species with less invasive implantation, including marsupials, may require different basal alterations for successful pregnancy. Here we used immunofluorescence microscopy and Western blotting to conduct the first study of basal plasma membrane dynamics in the uterus during marsupial pregnancy...
December 20, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27987347/integrated-analysis-reveals-candidate-mrna-and-their-potential-roles-in-uterine-leiomyomas
#8
Liping Xia, Yan Liu, Yan Fu, Shengyi Dongye, Dewei Wang
AIM: Uterine leiomyomas (UL) are the most common pelvic tumors, and the etiology and pathophysiology are not well understood. We aimed to elucidate the genes responsible for UL development. METHODS: Integrated analyses of four datasets of mRNA profiling for UL were performed. Functional annotation of differentially expressed genes (DEG) was used to systematically characterize the global expression profiles. The UL-specific protein-protein interaction network was constructed...
January 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27984777/concurrent-administration-of-diethylhexyl-phthalate-reduces-the-threshold-dose-at-which-bisphenol-a-disrupts-blastocyst-implantation-and-cadherins-in-mice
#9
Evan D Borman, Warren G Foster, Denys deCatanzaro
Many people are repeatedly exposed to both bisphenol A (BPA) and diethylhexyl phthalate (DEHP), but there has been little research concerning their effects in combination. Both can disrupt blastocyst implantation in inseminated females, albeit at high doses. We exposed mice on gestation days (GD) 1-4 to combinations of BPA and DEHP in doses below the threshold necessary to disrupt implantation on their own. On GD 6, there were fewer normally-developed implantation sites and more underdeveloped implantation sites in females given the combined subthreshold doses...
December 9, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27979666/cesarean-scar-pregnancy-comparing-the-efficacy-and-tolerability-of-treatment-with-high-intensity-focused-ultrasound-and-uterine-artery-embolization
#10
Juhua Xiao, Zhen Shi, Jinshui Zhou, Jun Ye, Jianfang Zhu, Xin Zhou, Fang Wang, Shouhua Zhang
The aim of this study was to investigate the clinical efficacy of high-intensity focused ultrasound (HIFU) for the treatment of a cesarean scar pregnancy compared with uterine artery embolization (UAE) and intra-arterial methotrexate infusion combined with uterine curettage. In this retrospective cohort study, 31 patients were treated with HIFU (HIFU group), and 45 patients were treated with UAE (UAE group). We compared the treatment and recovery of the patients, including follow-up. After UAE treatment, serum levels of the β subunit of human chorionic gonadotropin declined significantly on the first day, and the residual lesions disappeared in 3-17 wk...
December 12, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27943594/effects-of-quercetin-and-surgicel-for-preventing-adhesions-after-gynecological-surgery-a-rat-uterine-horn-model
#11
Gürhan Güney, Cihan Kaya, Gökhan Oto, Serkan Yıldırım, Hülya Özdemir, Aytekin Tokmak
AIM: Postoperative pelvic adhesions are significant health care problems causing chronic pelvic pain, infertility and intestinal obstruction after abdominal or pelvic surgery. We investigated the effects of quercetin and Surgicel for the prevention of adhesions after gynecological surgery. METHODS: A double blind, randomized, controlled experimental study was designed. Forty female Wistar Hannover rats were divided into five groups: control, sham operated, quercetin, Surgicel, and quercetin + Surgicel...
January 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27932523/treatment-of-recurrent-ovarian-cysts-and-primary-infertility-by-iranian-traditional-medicine-a-case-report
#12
Mehdi Salehi, Mohammad Setayesh, Roshanak Mokaberinejad
Infertility is a medical and psychosocial problem with a high prevalence. There are different treatments for this problem in Iranian traditional medicine. A 28-year-old woman presented with the complaints of 4 emergency operations of the left ovarian cyst during 4 years and infertility. Diagnostic laparoscopy showed an ovarian cyst, adhesion, and endometriosis. Hysteroscopy was unremarkable. After 2 months of letrozole administration, the ovarian cyst ruptured again. Considering the failure of conventional treatments, Iranian traditional medicine products were administered to the patient...
December 8, 2016: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/27925307/a-new-device-to-inseminate-cows-at-the-base-of-the-uterine-horns
#13
O García-Peña, R Rangel-Santos, R Rodríguez-De Lara, C A Apodaca-Sarabia, E Maldonado-Simán
A new device (Chapingo device) to deposit semen at the base of the uterine horns of cattle was developed at Universidad Autonoma Chapingo, Mexico. Nine Holstein heifers were inseminated by transvaginal laparoscopy, using a laparoscope for cattle and the Chapingo device. A dose of sexed semen (2.1 × 10(6) spermatozoa) was deposited at the base of the uterine horn ipsilateral to the ovary where the preovulatory follicle was identified. Insemination was achieved in all the heifers, taking on average 13.7 ± 3...
December 7, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27920582/surgeons-early-experience-with-the-acessa%C3%A2-procedure-gaining-proficiency-with-new-technology
#14
Kelli M Braun, Mark Sheridan, Erin Z Latif, Lexy Regush, Anet Maksymowicz, Laura Weins, Mohamed A Bedaiwy, Nerissa Tyson, Marilyn J Davidson, Barry H Sanders
PURPOSE: Successful adoption of a new surgical procedure varies among practicing surgeons, and skill acquisition depends on the surgeon's innate ability, the complexity of the technique, and training. We report intraoperative and near-term postoperative outcomes from the Acessa procedure conducted by minimally invasive gynecologic surgeons new to Acessa, and report the surgeons' experiences during the training period. PATIENTS AND METHODS: The study was designed as a postmarket, prospective, single-arm, multicenter analysis of operative and early postoperative outcomes after proctored surgical training with the Acessa device and procedure (laparoscopic ultrasound-guided radiofrequency volumetric thermal ablation of symptomatic fibroids) in premenopausal, menstruating women as conducted in community and university hospitals in the USA and Canada...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27908529/a-new-marker-insulinoma-associated-protein-1-insm1-for-high-grade-neuroendocrine-carcinoma-of-the-uterine-cervix-analysis-of-37-cases
#15
Shiho Kuji, Reiko Watanabe, Yuichi Sato, Takashi Iwata, Yasuyuki Hirashima, Munetaka Takekuma, Ichiro Ito, Masato Abe, Ryo Nagashio, Katsuhiro Omae, Daisuke Aoki, Toru Kameya
OBJECTIVE: High-grade neuroendocrine carcinoma of uterine cervix (HGNCUC) has been recognized as a highly malignant tumor. Therapeutic strategy specific to neuroendocrine (NE) tumors needs to be considered, but some cases wouldn't allow simple final diagnoses. Insulinoma-associated protein 1 (INSM1), which is a zinc-finger transcription factor related to NE differentiation, is frequently expressed in NE tumors. We investigated the association between INSM1 and HGNCUC, and the possibility of INSM1 as a useful NE marker...
November 28, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27905495/uterine-glands-impact-uterine-receptivity-luminal-fluid-homeostasis-and-blastocyst-implantation
#16
Andrew M Kelleher, Gregory W Burns, Susanta Behura, Guoyao Wu, Thomas E Spencer
Uterine glands are essential for pregnancy in mice and likely humans, because they secrete or transport bioactive substances that regulate uterine receptivity for blastocyst implantation. In mice, the uterus becomes receptive to blastocyst implantation on day 4, but is refractory by day 5. Here, blastocysts could be recovered from progesterone-induced uterine gland (PUGKO) but not wildtype (WT) mice on day 5 post-mating. Anti-adhesive Muc1 protein and microvilli were present on the luminal epithelium of PUGKO but not WT uteri...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896263/complete-vaginal-outlet-stenosis-in-a-patient-with-sheehan-s-syndrome
#17
Minji Choo, Hana Park, Kyong Wook Yi
We present a case of complete vaginal stenosis in a woman diagnosed with Sheehan's syndrome. The patient delivered at full-term 5 months prior, and experienced massive postpartum bleeding at that time. During evaluation of persistent amenorrhea, we found that her vaginal orifice was completely adhesive and obstructed. Prior to corrective surgery, we managed the patient with an oral contraceptive to induce uterine bleeding into the vaginal outflow tract. After three cycles of an oral contraceptive, we could confirm that there was no stenotic lesion in the vaginal cavity as a hematocolpos was created...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27871464/downregulation-of-mir-29a-b-c-in-placenta-accreta-inhibits-apoptosis-of-implantation-site-intermediate-trophoblast-cells-by-targeting-mcl1
#18
Yongzhong Gu, Yuehong Bian, Xiaofei Xu, Xietong Wang, Changting Zuo, Jinlai Meng, Hongyan Li, Shigang Zhao, Yunnan Ning, Yongzhi Cao, Tao Huang, Junhao Yan, Zi-Jiang Chen
OBJECTIVE: Placenta accreta is defined as abnormal adhesion of placental villi to the uterine myometrium. Although this condition has become more common as a result of the increasing rate of cesarean sections, the underlying causative mechanism(s) remain elusive. Because microRNA-29a/b/c (miR-29a/b/c) have been shown to play important roles in placental development, this study evaluated the roles of these microRNAs in placenta accreta. METHODS: Expression of miR-29a/b/c and myeloid cell leukemia-1 (MCL1) were quantified in patient tissues and HTR8/SVneo trophoblast cells using the real-time quantitative polymerase chain reaction...
December 2016: Placenta
https://www.readbyqxmd.com/read/27871060/involvement-of-serum-glucocorticoid-regulated-kinase-1-in-reproductive-success
#19
REVIEW
Yiyun Lou, Minhao Hu, Luna Mao, Yingming Zheng, Fan Jin
Reproductive processes, in particular events that concern pregnancy, are fine-tuned to produce offspring. Reproductive success is of prime importance for the survival of every species. The highly conserved and ubiquitously expressed serum glucocorticoid-regulated kinase 1 (SGK1) was first implicated in infertility as a regulator of a Na(+) channel. In this review, we emphasize the prominent role of SGK1 during early pregnancy: 1) balancing uterine luminal fluid secretion and reabsorption to aid blastocyst adhesion and to import nutrients and energy; 2) transducing signals from the blastocyst to the receptive endometrium; 3) inducing multiple genes that are involved in uterine receptivity and trophoblast invasion; 4) regulating cell differentiation and antioxidant defenses at the fetomaternal interface; and 5) contributing to the proliferation and survival of decidual stromal cells...
November 9, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27856386/reproductive-outcome-in-patients-with-intrauterine-adhesions-following-hysteroscopic-adhesiolysis-experience-from-the-largest-women-s-hospital-in-china
#20
Limei Chen, Hongwei Zhang, Qing Wang, Feng Xie, Shujun Gao, Yu Song, Jing Dong, Hua Feng, Kangyun Xie, Long Sui
STUDY OBJECTIVE: To analyze the reproductive outcome of hysteroscopic adhesiolysis and assess the diagnostic accuracy of transvaginal ultrasonography (TVS) in infertile women resulting from intrauterine adhesions (IUAs) DESIGN: Retrospective , cross-sectional study (Canadian Task Force classification II-2). SETTING: University tertiary referral center PATIENTS: Three hundred and fifty seven patients with mild, moderate, and severe IUAs underwent hysteroscopic adhesiolysis between January 2012 and December 2015 INTERVENTIONS: Hysteroscopic adhesiolysis in the outpatient analgesic setting for infertility and IUAs...
November 14, 2016: Journal of Minimally Invasive Gynecology
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