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https://www.readbyqxmd.com/read/28239909/ledipasvir-sofosbuvir-is-effective-and-well-tolerated-in-post-kidney-transplant-patients-with-chronic-hepatitis-c-virus
#1
Amilcar L Morales, Luz Liriano-Ward, Amber Tierney, Michelle Sang, Alexander Lalos, Mohamed Hassan, Vinay Nair, Thomas Schiano, Rohit Satoskar, Coleman Smith
Patients with end stage renal diseases on hemodialysis have a high prevalence of hepatitis C infection (HCV). In most patients treatment for HCV is delayed until post renal transplant. We assessed the effectiveness and tolerance of ledipasvir/sofosbuvir (LDV/SOF) in 32 post-kidney transplant patients infected with HCV. The group was composed predominantly of treatment naïve (75%) African American (68.75%) males (75%) infected with genotype 1a (62.5%). Most patients received a deceased donor kidney graft (78...
February 26, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28239678/bidirectional-intragraft-alloreactivity-drives-the-repopulation-of-human-intestinal-allografts-and-correlates-with-clinical-outcome
#2
Julien Zuber, Brittany Shonts, Sai-Ping Lau, Aleksandar Obradovic, Jianing Fu, Suxiao Yang, Marion Lambert, Shana Coley, Joshua Weiner, Joseph Thome, Susan DeWolf, Donna L Farber, Yufeng Shen, Sophie Caillat-Zucman, Govind Bhagat, Adam Griesemer, Mercedes Martinez, Tomoaki Kato, Megan Sykes
A paradigm in transplantation states that graft-infiltrating T cells are largely non-alloreactive "bystander" cells. However, the origin and specificity of allograft T cells over time has not been investigated in detail in animals or humans. Here, we use polychromatic flow cytometry and high throughput TCR sequencing of serial biopsies to show that gut-resident T cell turnover kinetics in human intestinal allografts are correlated with the balance between intra-graft host-vs-graft (HvG) and graft-vs-host (GvH) reactivities and with clinical outcomes...
October 2016: Science Immunology
https://www.readbyqxmd.com/read/28239596/genetic-diversity-of-atlantic-bluefin-tuna-in-the-mediterranean-sea-insights-from-genome-wide-snps-and-microsatellites
#3
Aglaia Antoniou, Panagiotis Kasapidis, Georgios Kotoulas, Constantinos C Mylonas, Antonios Magoulas
BACKGROUND: Elucidating the patterns of the Atlantic Bluefin tuna [ABFT, Thunnus thynnus (Linnaeus, 1758)] population structure constitutes a challenging task of great importance. Most of the unique challenges stem from its biology, as well as the attributes of the marine realm in which it disperses. Accurate information is urgently needed for stock assessment, and the identification of critical features to the persistence and adaptation of populations in order to formulate and adopt effective strategies for ABFT conservation and management...
December 2017: Journal of Biological Research
https://www.readbyqxmd.com/read/28239392/zoeppritz-based-avo-inversion-using-an-improved-markov-chain-monte-carlo-method
#4
Xin-Peng Pan, Guang-Zhi Zhang, Jia-Jia Zhang, Xing-Yao Yin
The conventional Markov chain Monte Carlo (MCMC) method is limited to the selected shape and size of proposal distribution and is not easy to start when the initial proposal distribution is far away from the target distribution. To overcome these drawbacks of the conventional MCMC method, two useful improvements in MCMC method, adaptive Metropolis (AM) algorithm and delayed rejection (DR) algorithm, are attempted to be combined. The AM algorithm aims at adapting the proposal distribution by using the generated estimators, and the DR algorithm aims at enhancing the efficiency of the improved MCMC method...
2017: Pet Sci
https://www.readbyqxmd.com/read/28239386/local-climate-heterogeneity-shapes-population-genetic-structure-of-two-undifferentiated-insular-scutellaria-species
#5
Huan-Yi Hsiung, Bing-Hong Huang, Jui-Tse Chang, Yao-Moan Huang, Chih-Wei Huang, Pei-Chun Liao
Spatial climate heterogeneity may not only affect adaptive gene frequencies but could also indirectly shape the genetic structure of neutral loci by impacting demographic dynamics. In this study, the effect of local climate on population genetic variation was tested in two phylogenetically close Scutellaria species in Taiwan. Scutellaria taipeiensis, which was originally assumed to be an endemic species of Taiwan Island, is shown to be part of the widespread species S. barbata based on the overlapping ranges of genetic variation and climatic niches as well as their morphological similarity...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28239383/effects-of-cigarette-smoking-on-transplant-survival-extending-or-shortening-it
#6
Feifei Qiu, Ping Fan, Golay D Nie, Huazhen Liu, Chun-Ling Liang, Wanlin Yu, Zhenhua Dai
Cigarette smoking (CS) regulates both innate and adaptive immunity and causes numerous diseases, including cardiovascular, respiratory, and autoimmune diseases, allergies, cancers, and transplant rejection. Therefore, smoking poses a serious challenge to the healthcare system worldwide. Epidemiological studies have always shown that CS is one of the major risk factors for transplant rejection, even though smoking plays redundant roles in regulating immune responses. The complex roles for smoking in immunoregulation are likely due to molecular and functional diversities of cigarette smoke components, including carbon monoxide (CO) and nicotine...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28238971/writing-signed-languages-what-for-what-form
#7
Donald A Grushkin
Signed languages around the world have tended to maintain an "oral," unwritten status. Despite the advantages of possessing a written form of their language, signed language communities typically resist and reject attempts to create such written forms. The present article addresses many of the arguments against written forms of signed languages, and presents the potential advantages of writing signed languages. Following a history of the development of writing in spoken as well as signed language populations, the effects of orthographic types upon literacy and biliteracy are explored...
2017: American Annals of the Deaf
https://www.readbyqxmd.com/read/28238695/how-expert-clinicians-intuitively-recognize-a-medical-diagnosis
#8
REVIEW
John E Brush, Jonathan Sherbino, Geoffrey R Norman
Research has shown that expert clinicians make a medical diagnosis through a process of hypothesis generation and verification. Experts begin the diagnostic process by generating a list of diagnostic hypotheses using intuitive, non-analytical reasoning. Analytical reasoning then allows the clinician to test and verify or reject each hypothesis, leading to a diagnostic conclusion. In this paper, we focus on the initial step of hypothesis generation and review how expert clinicians use experiential knowledge to intuitively recognize a medical diagnosis...
February 24, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28238223/glucose-lowering-agents-for-treating-pre-existing-and-new-onset-diabetes-in-kidney-transplant-recipients
#9
REVIEW
Clement Lo, Min Jun, Sunil V Badve, Helen Pilmore, Sarah L White, Carmel Hawley, Alan Cass, Vlado Perkovic, Sophia Zoungas
BACKGROUND: Kidney transplantation is the preferred form of kidney replacement therapy for patients with end-stage kidney disease (ESKD) and is often complicated by worsening or new-onset diabetes. Management of hyperglycaemia is important to reduce post-transplant and diabetes-related complications. The safety and efficacy of glucose-lowering agents after kidney transplantation is largely unknown. OBJECTIVES: To evaluate the efficacy and safety of pharmacological interventions for lowering glucose levels in patients who have undergone kidney transplantation and have diabetes...
February 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28237928/robust-multi-exposure-image-fusion-a-structural-patch-decomposition-approach
#10
Kede Ma, Hui Li, Hongwei Yong, Zhou Wang, Deyu Meng, Lei Zhang
We propose a simple yet effective structural patch decomposition (SPD) approach for multi-exposure image fusion (MEF) that is robust to ghosting effect. We decompose an image patch into three conceptually independent components: signal strength, signal structure, and mean intensity. Upon fusing these three components separately, we reconstruct a desired patch and place it back into the fused image. This novel patch decomposition approach benefits MEF in many aspects. First, as opposed to most pixel-wise MEF methods, the proposed algorithm does not require post-processing steps to improve visual quality or to reduce spatial artifacts...
February 20, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28237923/maven-an-algorithm-for-multi-parametric-automated-segmentation-of-brain-veins-from-gradient-echo-acquisitions
#11
Serena Monti, Sirio Cocozza, Pasquale Borrelli, Sina Straub, Mark E Ladd, Marco Salvatore, Enrico Tedeschi, Giuseppe Palma
Cerebral vein analysis provides a chance to study, from an unusual viewpoint, an entire class of brain diseases, including neurodegenerative disorders and traumatic brain injuries. Manual segmentation approaches can be used to assess vascular anatomy, but they are observer-dependent and time consuming; therefore, automated approaches are desirable, as they also improve reproducibility. In the present work, a new, fully automated algorithm, based on structural, morphological and relaxometric information, is proposed to segment the entire cerebral venous system from MR images...
February 20, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28237390/clinical-xenotransplantation-a-closer-reality-literature-review
#12
Ana María Aristizabal, Luis Armando Caicedo, Juan Manuel Martínez, Manuel Moreno, Gabriel J Echeverri
Xenotransplantation could provide an unlimited supply of organs and solve the current shortage of organs for transplantation. To become a reality in clinical practice, the immunological and physiological barriers and the risk of xenozoonosis that they possess should be resolved. From the immunological point of view, in the last 30 years a significant progress in the production of transgenic pigs has prevented the hyperacute rejection. About xenozoonosis, attention has been focused on the risk of transmission of porcine endogenous retroviruses; however, today, it is considered that the risk is very low and the inevitable transmission should not prevent the clinical xenotransplantation...
February 22, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28236795/therapeutic-monitoring-of-pediatric-transplant-patients-with-conversion-to-generic-tacrolimus
#13
Natalia Riva, Paulo Cáceres Guido, Nieves Licciardone, Oscar Imventarza, Marta Monteverde, Raquel Staciuk, Alberto Charroqui, Paula Schaiquevich
OBJECTIVE: Therapeutic monitoring during interchange of tacrolimus commercial formulations is essential to ensure similar exposure in transplant patients. However, there are limited data in the pediatric transplant population. This study aims to evaluate exposure, safety and efficacy in maintenance pediatric transplant patients under generic tacrolimus substitution. METHOD: Pediatric patients who underwent interchange of tacrolimus formulations were detected by the Service of Pharmacy and included in this study...
March 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28236636/re-evaluation-of-glomerulitis-using-occlusion-criteria-based-on-the-banff-2013-revision
#14
Yasemin Ozluk, Yasar Caliskan, Mustafa Sevinc, Aysel Bayram, Evsen Apaydin Arikan, Aydin Turkmen, Sebahat Akgul, Fatma Oguz Savran, Mehmet Sukru Sever, Isin Kilicaslan
The presence of occlusion/near-occlusion of glomerular capillaries was recently added to the existing definition of glomerulitis (g). We retrospectively re-evaluated 135 renal allograft biopsies regarding g to ensure no antibody-damaged grafts were missed. Previous and revised g scores (pg and rg, respectively) were compared for clinicopathologic correlations. The g score did not change in 100 (74.1%) biopsies. Thirty-five (25.9%) biopsies were changed to a lower score. Sensitivity and specificity of pg and rg for the presence of donor specific antibodies (DSA) were 76% vs...
February 25, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28236626/selecting-multi-rule-quality-control-procedures-based-on-patient-risk
#15
Hassan Bayat
BACKGROUND: Traditionally, statistical quality control (SQC) planning is aimed at preventing the error rate from exceeding a pre-defined acceptable rate (Westgard JO. Basic QC Practices, 4th ed. Westgard QC, 2016). A pivotal characteristic for planning a QC procedure with the traditional approach is the probability of rejecting an analytical run that contains critical size errors (Pedc). Multi-rule QC procedures, with fully documented power curves, are important tools for SQC. In addition, it has been recommended (Parvin CA, Gronowski AM...
February 25, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28236496/-inequity-of-compensation-trajectories-for-victims-of-medical-injuries-a-survey-in-the-french-out-of-court-settlement-mechanism
#16
I Parizot, I Cailbault, M Winance, J Barbot
BACKGROUND: In France little is known about either the characteristics of people who take legal action because they believe themselves to be victims of harm caused by medical activity, or about their complaint trajectory. The law of 4th March 2002 created an out-of-court settlement mechanism which aims to reduce inequitable access to compensation experienced by victims faced with legal procedures that are both lengthy and costly. This mechanism now occupies a central position among the avenues of recourse available to patients and their families...
February 21, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28236143/c3-glomerulopathy-and-eculizumab-a-report-on-four-paediatric-cases
#17
Célia Lebreton, Justine Bacchetta, Frédérique Dijoud, Lucie Bessenay, Véronique Fremeaux-Bacchi, Anne Laure Sellier-Leclerc
BACKGROUND: Eculizumab may be used to treat C3-glomerulopathy (C3G), a rare but severe glomerular disease. DIAGNOSIS AND TREATMENT: Patients 1, 2 and 3 were diagnosed with nephritic syndrome with alternative complement pathway activation (low C3, C3Nef-positive) and C3G at the age of 9, 13 and 12 years, respectively. Treatment with eculizumab normalized proteinuria within 1, 2 and 7 months, respectively. Proteinuria relapsed when eculizumab was withdrawn, but the re-introduction of eculizumab normalized proteinuria...
February 24, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28235982/-transcutaneous-osseointegration-after-limb-amputation-a-review-over-27-years
#18
Horst-Heinrich Aschoff
Intramedullary, bone-anchored (osseointegrated), transcutaneous docking of artificial limbs has been in clinical use for more than 25 years. This system of prosthetic limb attachment is a valuable treatment option in the rehabilitation of patients after limb amputation. Only a few centers are systematically investigating this topic worldwide so that current knowledge on this special treatment option is still limited; however, mainstream medical opinion still regards percutaneous skeletal prosthetic docking with some skepticism...
February 24, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28235667/automated-detection-of-high-frequency-oscillations-in-electrophysiological-signals-methodological-advances
#19
Miguel Navarrete, Jan Pyrzowski, Juliana Corlier, Mario Valderrama, Michel Le Van Quyen
In recent years, new recording technologies have advanced such that oscillations of neuronal networks can be identified from simultaneous, multisite recordings at high temporal and spatial resolutions. However, because of the deluge of multichannel data generated by these experiments, achieving the full potential of parallel neuronal recordings also depends on the development of new mathematical methods capable of extracting meaningful information related to time, frequency and space. In this review, we aim to bridge this gap by focusing on the new analysis tools developed for the automated detection of high-frequency oscillations (HFOs, > 40 Hz) in local field potentials...
February 21, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28230712/updating-evidence-for-using-hypothermia-in-pediatric-severe-traumatic-brain-injury-conventional-and-bayesian-meta-analytic-perspectives
#20
Robert C Tasker, Frederick W Vonberg, Elizabeth D Ulano, Alireza Akhondi-Asl
OBJECTIVE: To evaluate clinical trials of hypothermia management on outcome in pediatric patients with severe traumatic brain injury using conventional and Bayesian meta-analyses. DATA SOURCES: Screening of PubMed and other databases to identify randomized controlled trials of hypothermia for pediatric severe traumatic brain injury published before September 2016. STUDY SELECTION: Four investigators assessed and reviewed randomized controlled trial data...
February 20, 2017: Pediatric Critical Care Medicine
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