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https://www.readbyqxmd.com/read/29035048/structural-sequencing-of-oligopeptides-aided-by-1-h-iterative-full-spin-analysis
#1
Wei Gao, James B McAlpine, Mary P Choules, José G Napolitano, David C Lankin, Charlotte Simmler, Ngoc Anh Ho, Hanki Lee, Joo-Won Suh, Ian W Burton, Sanghyun Cho, Scott G Franzblau, Shao-Nong Chen, Guido F Pauli
This report describes an approach using (1)H NMR iterative full-spin analysis (HiFSA) to extract definitive structural information on unknown peptides from 1D (1)H NMR data. By comparing the experimental data and HiFSA fingerprint of a known analogue, it is possible to isolate the characteristic (1)H subspectrum of the different amino acids and, thus, elucidate the structure of the peptide. To illustrate this methodology, a comprehensive analysis of five new anti-Mycobacterium tuberculosis peptides (2-6), all analogues of ecumicin (1), was carried out...
October 16, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29030857/funding-blood-safety-in-the-21st-century
#2
Luke Ifland, Evan M Bloch, John P Pitman
BACKGROUND: Since 2000, there has been an historic increase in international development assistance, including blood safety projects. The result has been increased blood donations and infectious disease screening in many beneficiary countries. A comprehensive examination of international development assistance for blood safety has yet to be completed. STUDY DESIGN AND METHODS: This report examines publicly available information, including donor agency websites and databases and data from the 2008 and 2012 World Health Organization Global Database on Blood Safety...
October 13, 2017: Transfusion
https://www.readbyqxmd.com/read/29028662/stool-xpert-mtb-rif-and-urine-lipoarabinomannan-lam-for-diagnosing-tuberculosis-in-hospitalized-hiv-infected-children
#3
Sylvia M LaCourse, Patricia B Pavlinac, Lisa M Cranmer, Irene N Njuguna, Cyrus Mugo, John Gatimu, Joshua Stern, Judd L Walson, Elizabeth Maleche-Obimbo, Julius Oyugi, Dalton Wamalwa, Grace John-Stewart
BACKGROUND: Tuberculosis (TB) causes substantial morbidity and mortality in HIV-infected children. Sample collection and paucibacillary nature of TB in children makes diagnosis challenging. Rapid diagnostic tools using easily obtained specimens are urgently needed. METHODS: Hospitalized, HIV-infected children ≤12 years enrolled in a randomized controlled trial (NCT02063880) comparing urgent to poststabilization ART initiation in Kenya underwent TB evaluation. At enrollment, sputum or gastric aspirates (GA) were collected for TB culture and Xpert, stool for Xpert, and urine for lateral flow lipoarabinomannan (LAM )...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29025631/effect-of-isoniazid-preventive-therapy-on-risk-of-death-in-west-african-hiv-infected-adults-with-high-cd4-cell-counts-long-term-follow-up-of-the-temprano-anrs-12136-trial
#4
Anani Badje, Raoul Moh, Delphine Gabillard, Calixte Guéhi, Mathieu Kabran, Jean-Baptiste Ntakpé, Jérôme Le Carrou, Gérard M Kouame, Eric Ouattara, Eugène Messou, Amani Anzian, Albert Minga, Joachim Gnokoro, Patrice Gouesse, Arlette Emieme, Thomas-d'Aquin Toni, Cyprien Rabe, Baba Sidibé, Gustave Nzunetu, Lambert Dohoun, Abo Yao, Synali Kamagate, Solange Amon, Amadou-Barenson Kouame, Aboli Koua, Emmanuel Kouamé, Marcelle Daligou, Denise Hawerlander, Simplice Ackoundzé, Serge Koule, Jonas Séri, Alex Ani, Fassery Dembélé, Fatoumata Koné, Mykayila Oyebi, Nathalie Mbakop, Oyewole Makaila, Carolle Babatunde, Nathaniel Babatunde, Gisèle Bleoué, Mireille Tchoutedjem, Alain-Claude Kouadio, Ghislaine Sena, Sahinou-Yediga Yededji, Sophie Karcher, Christine Rouzioux, Abo Kouame, Rodrigue Assi, Alima Bakayoko, Serge K Domoua, Nina Deschamps, Kakou Aka, Thérèse N'Dri-Yoman, Roger Salamon, Valérie Journot, Hughes Ahibo, Timothée Ouassa, Hervé Menan, André Inwoley, Christine Danel, Serge P Eholié, Xavier Anglaret
BACKGROUND: Temprano ANRS 12136 was a factorial 2 × 2 trial that assessed the benefits of early antiretroviral therapy (ART; ie, in patients who had not reached the CD4 cell count threshold used to recommend starting ART, as per the WHO guidelines that were the standard during the study period) and 6-month isoniazid preventive therapy (IPT) in HIV-infected adults in Côte d'Ivoire. Early ART and IPT were shown to independently reduce the risk of severe morbidity at 30 months. Here, we present the efficacy of IPT in reducing mortality from the long-term follow-up of Temprano...
November 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29022526/cytomegalovirus-retinitis-and-hiv-case-reviews-from-kwazulu-natal-province-south-africa
#5
R Hassan-Moosa, T Chinappa, L Jeena, L Visser, K Naidoo
BACKGROUND: Retinal cytomegalovirus (CMV) infection is a common opportunistic infection and remains a significant contributor to visual loss in patients with AIDS. We highlight the poor outcomes of CMV retinitis in three HIV-infected patients who were initiated on antiretroviral therapy (ART). We conducted a retrospective chart review of advanced stage HIV-infected patients with known CMV retinitis.Case 1. A 37-year-old man, with a CD4+ cell count of 35 cells/µL, presented for ART initiation with a 5-month history of visual loss in his left eye...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29020277/hiv-care-access-among-people-with-incarceration-experience-in-st-petersburg-russia
#6
Monica S Ruiz, Robert Heimer, Olga S Levina, N V Badosova, Vadim V Rassokhin, Andrey N Belyakov, Nikolai A Belyakov
Background: Little is known about the clinical care experiences of HIV-infected persons in St. Petersburg who have experience with incarceration. To address this question, we conducted a capture-recapture study to identify individuals who had been diagnosed with HIV infection while incarcerated and who subsequently presented for medical care in St. Petersburg, Russia following release from prison. Methods: We matched 292 HIV-positive prisoners tested by the prison system in 2010 to the medical records at the St...
August 31, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29018323/cerebrospinal-fluid-amino-acid-profiling-of-pediatric-cases-with-tuberculous-meningitis
#7
Shayne Mason, Carolus J Reinecke, Regan Solomons
Background: In Africa, tuberculosis is generally regarded as persisting as one of the most devastating infectious diseases. The pediatric population is particularly vulnerable, with infection of the brain in the form of tuberculous meningitis (TBM) being the most severe manifestation. TBM is often difficult to diagnose in its early stages because of its non-specific clinical presentation. Of particular concern is that late diagnosis, and subsequent delayed treatment, leads to high risk of long-term neurological sequelae, and even death...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28993169/anti-tuberculosis-drug-combination-for-controlled-oral-delivery-using-3d-printed-compartmental-dosage-forms-from-drug-product-design-to-in-vivo-testing
#8
Natalja Genina, Johan Peter Boetker, Stefano Colombo, Necati Harmankaya, Jukka Rantanen, Adam Bohr
The design and production of an oral dual-compartmental dosage unit (dcDU) was examined in vitro and in vivo with the purpose of physically isolating and modulating the release profile of an anti-tuberculosis drug combination. Rifampicin (RIF) and isoniazid (ISO) are first line combination drugs for treatment of tuberculosis (TB) that negatively interact with each other upon simultaneous release in acidic environment. The dcDUs were designed in silico by computer aided design (CAD) and fabricated in two steps; first three-dimensional (3D) printing of the outer structure, followed by hot-melt extrusion (HME) of the drug-containing filaments...
October 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28990409/hiv-primary-care-by-the-infectious-disease-physician-in-the-united-states-extending-the-continuum-of-care
#9
Seetha Lakshmi, Susan E Beekmann, Philip M Polgreen, Allan Rodriguez, Maria L Alcaide
Models of care for people living with HIV (PLWH) have varied over time due to long term survival, development of HIV-associated non-AIDS conditions, and HIV specific primary care guidelines that differ from those of the general population. The objectives of this study are to assess how often infectious disease (ID) physicians provide primary care for PLWH, assess their practice patterns and barriers in the provision of primary care. We used a 6-item survey electronically distributed to ID physician members of Emerging Infections Network (EIN)...
October 9, 2017: AIDS Care
https://www.readbyqxmd.com/read/28980964/tuberculosis-and-hiv-aids-the-alien-and-the-predator
#10
Vadim Pokrovsky
No abstract text is available yet for this article.
September 30, 2017: Lancet
https://www.readbyqxmd.com/read/28969114/oxidative-stress-markers-in-tuberculosis-and-hiv-tb-co-infection
#11
Shreewardhan Haribhau Rajopadhye, Sandeepan R Mukherjee, Abhay S Chowdhary, Sucheta P Dandekar
INTRODUCTION: Dysfunction of redox homeostasis has been implicated in many pathological conditions. An imbalance of pro- and anti-oxidants have been observed in Tuberculosis (TB) and its co-morbidities especially HIV/AIDS. The pro inflammatory milieu in either condition aggravates the physiological balance of the redox mechanisms. The present study therefore focuses on assessing the redox status of patients suffering from TB and HIV-TB co-infection. AIM: To assess the oxidative stress markers in the HIV-TB and TB study cohort...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28966063/adaptive-gene-profiling-of-mycobacterium-tuberculosis-during-sub-lethal-kanamycin-exposure
#12
Zeshan Habib, Weize Xu, Muhammad Jamal, Khaista Rehman, Jinxia Dai, Zhen Fang Fu, Xi Chen, Gang Cao
Resistance to anti-tuberculosis drugs is a formidable obstacle to effective tuberculosis (TB) treatment and prevention globally. New forms of multidrug, extensive drug and total drug resistance Mycobacterium tuberculosis (Mtb) causing a serious threat to human as well as animal's population. Mtb shows diverse adaptability under stress conditions especially antibiotic treatment, however underlying physiological mechanism remained elusive. In present study, we investigated Mtb's response and adaptation with reference to gene expression during sub-lethal kanamycin exposure...
September 28, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28954600/disseminated-histoplasmosis-case-report-and-review-of-the-literature
#13
Séverine Evrard, Philippe Caprasse, Pierre Gavage, Myriam Vasbien, Jean Radermacher, Marie-Pierre Hayette, Rosalie Sacheli, Marjan Van Esbroeck, Lieselotte Cnops, Eric Firre, Laurent Médart, Filip Moerman, Jean-Marc Minon
Case report We report the case of a young Cameroonian woman who presented with cough, hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology was discovered and a chest radiography revealed a 'miliary pattern'. Bone marrow aspiration pointed out yeast inclusions within macrophages. Given the morphological aspect, the clinical presentation and immunosuppression, histoplasmosis was retained as a working hypothesis. Antiretroviral and amphotericin B treatments were promptly initiated...
September 28, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28954163/use-of-the-coding-causes-of-death-in-hiv-in-the-classification-of-deaths-in-northeastern-brazil
#14
Diana Neves Alves, Cristiane Campello Bresani-Salvi, Joanna d'Arc Lyra Batista, Ricardo Arraes de Alencar Ximenes, Demócrito de Barros Miranda-Filho, Heloísa Ramos Lacerda de Melo, Maria de Fátima Pessoa Militão de Albuquerque
OBJECTIVE: Describe the coding process of death causes for people living with HIV/AIDS, and classify deaths as related or unrelated to immunodeficiency by applying the Coding Causes of Death in HIV (CoDe) system. METHODS: A cross-sectional study that codifies and classifies the causes of deaths occurring in a cohort of 2,372 people living with HIV/AIDS, monitored between 2007 and 2012, in two specialized HIV care services in Pernambuco. The causes of death already codified according to the International Classification of Diseases were recoded and classified as deaths related and unrelated to immunodeficiency by the CoDe system...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28954053/hiv-aids-tuberculosis-and-tobacco-in-brazil-a-syndemic-that-calls-for-integrated-interventions
#15
Thomas Novotny, Erik Hendrickson, Elizabeth C C Soares, Andrea B Sereno, Susan M Kiene
No abstract text is available yet for this article.
September 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28949465/how-should-global-fund-use-value-for-money-information-to-sustain-its-investments-in-graduating-countries
#16
Kitti Kanpirom, Alia Cynthia G Luz, Kalipso Chalkidou, Yot Teerawattananon
It has been debated whether the Global Fund (GF), which is supporting the implementation of programs on the prevention and control of HIV/AIDS, tuberculosis (TB) and malaria, should consider the value-for-money (VFM) for programs/interventions that they are supporting. In this paper, we critically analyze the uses of economic information for GF programs, not only to ensure accountability to their donors but also to support country governments in continuing investment in cost-effective interventions initiated by the GF despite the discontinuation of financial support after graduation...
February 27, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28944450/review-dynamic-spatial-models-of-parasite-transmission-in-wildlife-their-structure-applications-and-remaining-challenges
#17
REVIEW
L A White, J D Forester, M E Craft
1.Individual differences in contact rate can arise from host, group, and landscape heterogeneity and can result in different patterns of spatial spread for diseases in wildlife populations with concomitant implications for disease control in wildlife of conservation concern, livestock, and humans. While dynamic disease models can provide a better understanding of the drivers of spatial spread, the effects of landscape heterogeneity have only been modelled in a few well-studied wildlife systems such as rabies and bovine tuberculosis...
September 25, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28941857/a-cross-sectional-study-to-assess-the-stigma-associated-with-tuberculosis-among-tuberculosis-patients-in-udupi-district-karnataka
#18
R Shivapujimath, A P Rao, A R Nilima, D M Shilpa
BACKGROUND: For decades, tuberculosis and other communicable diseases like human immunodeficiency virus/acquired immune deficiency syndrome, leprosy, etc., have been associated with stigma and discrimination by the society; this can interfere with the lifestyle and disease management among these patients. OBJECTIVE: To assess the stigma experienced by tuberculosis patients and to find the factors associated with stigma. METHODS: A cross-sectional study was conducted among 209 sputum-positive and sputum-negative tuberculosis patients...
October 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28928997/neurosyphilis-with-concomitant-cryptococcal-and-tuberculous-meningitis-in-a-patient-with-aids-report-of-a-unique-case
#19
Jose Armando Gonzales Zamora, Luis Alberto Espinoza, Rita N Nwanyanwu
Meningitis in individuals living with acquired immunodeficiency syndrome (AIDS) is most frequently infectious in origin and usually due to opportunistic infections. The most common pathogens are Cryptococcus neoformans and Mycobacterium tuberculosis. Treponema pallidum causes neurosyphilis and can complicate HIV infections at any time after the initial infection. Simultaneous infections of the central nervous system caused by these pathogens are very uncommon even in the setting of severe immunosuppression...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28919116/global-regional-and-national-age-sex-specific-mortality-for-264-causes-of-death-1980-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#20
(no author information available yet)
BACKGROUND: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. METHODS: We estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year...
September 16, 2017: Lancet
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