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https://www.readbyqxmd.com/read/29332319/treatment-of-latent-tuberculosis-infection-and-its-clinical-efficacy
#1
REVIEW
Hyung Woo Kim, Ju Sang Kim
The role of the treatment for latent tuberculosis infection (LTBI) has been underscored in the intermediate tuberculosis (TB) burden countries like South Korea. LTBI treatment is recommended only for patients at risk for progression to active TB-those with frequent exposure to active TB cases, and those with clinical risk factors (e.g., immunocompromised patients). Recently revised National Institute for Health and Care Excellence (NICE) guideline recommended that close contacts of individuals with active pulmonary or laryngeal TB, aged between 18 and 65 years, should undergo LTBI treatment...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29330673/vacuum-assisted-closure-therapy-of-paradoxical-reaction-in-tuberculous-lymphadenopathy-caused-by-mycobacterium-africanum
#2
H F Geerdes-Fenge, P Pongratz, J Liese, E C Reisinger
A 26-year-old HIV-negative male from Ghana was treated for cervical, intrathoracic and abdominal lymph node tuberculosis (TB) and tuberculous hepatitis. Penetration of the thoracic trachea by a mediastinal lymph node had caused bronchomucosal TB. Sputum culture grew M. africanum, sensitive to all first-line antituberculous drugs. Four weeks after the beginning of directly observed treatment with isoniazid, rifampin, pyrazinamide and ethambutol, the right cervical lymph node increased in size, liquefied and caused a spontaneous fistula...
January 12, 2018: Infection
https://www.readbyqxmd.com/read/29326013/a-cluster-of-multidrug-resistant-mycobacterium-tuberculosis-among-patients-arriving-in-europe-from-the-horn-of-africa-a-molecular-epidemiological-study
#3
Timothy M Walker, Matthias Merker, Astrid M Knoblauch, Peter Helbling, Otto D Schoch, Marieke J van der Werf, Katharina Kranzer, Lena Fiebig, Stefan Kröger, Walter Haas, Harald Hoffmann, Alexander Indra, Adrian Egli, Daniela M Cirillo, Jérôme Robert, Thomas R Rogers, Ramona Groenheit, Anne T Mengshoel, Vanessa Mathys, Marjo Haanperä, Dick van Soolingen, Stefan Niemann, Erik C Böttger, Peter M Keller
BACKGROUND: The risk of tuberculosis outbreaks among people fleeing hardship for refuge in Europe is heightened. We describe the cross-border European response to an outbreak of multidrug-resistant tuberculosis among patients from the Horn of Africa and Sudan. METHODS: On April 29 and May 30, 2016, the Swiss and German National Mycobacterial Reference Laboratories independently triggered an outbreak investigation after four patients were diagnosed with multidrug-resistant tuberculosis...
January 8, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29324337/amino-acid-conjugated-antimicrobial-drugs-synthesis-lipophilicity-activity-relationship-antibacterial-and-urease-inhibition-activity
#4
Atta Ullah, Fatima Iftikhar, Muhammad Arfan, Syeda Tayyaba Batool Kazmi, Muhammad Naveed Anjum, Ihsan-Ul Haq, Muhammad Ayaz, Sadia Farooq, Umer Rashid
Present work describes the in vitro antibacterial evaluation of some new amino acid conjugated antimicrobial drugs. Structural modification was attempted on the three existing antimicrobial pharmaceuticals namely trimethoprim, metronidazole, isoniazid. Twenty one compounds from seven series of conjugates of these drugs were synthesized by coupling with some selected Boc-protected amino acids. The effect of structural features and lipophilicity on the antibacterial activity was investigated. The synthesized compounds were evaluated against five standard American type culture collection (ATCC) i...
December 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29322014/protective-effects-of-salep-against-isoniazid-liver-toxicity-in-wistar-rats
#5
Hossein Kargar Jahromi, Morteza Pourahmad, Hassan Ali Abedi, Mohadeseh Karimi, Zahra Kargar Jahromi
Introduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this side effect of isoniazid. Materials and methods: This study is an experimental study in which the preventive effect of salep on isoniazid hepatotoxicity is evaluated. In this study 56 rats were randomly placed in 7 eight members groups including: control group, sham, isoniazid and four isoniazid/salep groups...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321414/the-platelet-count-can-predict-in-hospital-death-in-hiv-negative-smear-positive-pulmonary-tuberculosis-inpatients
#6
Hideto Goto, Nobuyuki Horita, Ken Tashiro, Kenjiro Nagai, Masaki Yamamoto, Takashi Sato, Yu Hara, Hideyuki Nagakura, Yuji Shibata, Hiroki Watanabe, Kentaro Nakashima, Ryota Ushio, Akimichi Nagashima, Misako Ikeda, Atsuya Narita, Katsuhito Sasaki, Nobuaki Kobayashi, Makoto Kudo, Takeshi Kaneko
Introduction This retrospective cohort study investigated whether the three components of the blood cell count have prognostic implications in HIV-negative Japanese adult inpatients with smear-positive pulmonary tuberculosis. Methods We reviewed patients who were treated by the isoniazid, rifampicin, pyrazinamide, and ethambutol regimen or by the isoniazid, rifampicin, and ethambutol regimen. The association between the patient data on admission and the survival outcome was evaluated. Results We reviewed 367 consecutive patients (male, 60...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29313577/a-randomized-controlled-phase-iii-clinical-trial-to-evaluate-the-efficacy-and-tolerability-of-risorine-with-conventional-rifampicin-in-the-treatment-of-newly-diagnosed-pulmonary-tuberculosis-patients
#7
Naresh Patel, K Jagannath, Agam Vora, Mukesh Patel, Anand Patel
Background: The overall goals for treatment of Tuberculosis (TB) are to cure individual patient and to minimize the transmission of Mycobacterium tuberculosis. At the time of study conduction, the standard treatment for newly diagnosed tuberculosis patients consisted of an intensive phase for two months with four drugs (HRZE), followed by continuation phase for four months with two drugs (HR). Rifampicin, which is very effective against Mycobacterium tuberculosis, in both the phases of treatment, has certain concerns, which includes, decreased bioavailability with chronic use and hepatotoxicity...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29310751/multi-clonal-evolution-of-multi-drug-resistant-extensively-drug-resistant-mycobacterium-tuberculosis-in-a-high-prevalence-setting-of-papua-new-guinea-for-over-three-decades
#8
Arnold Bainomugisa, Evelyn Lavu, Stenard Hiashiri, Suman Majumdar, Alice Honjepari, Rendi Moke, Paison Dakulala, Grant A Hill-Cawthorne, Sushil Pandey, Ben J Marais, Chris Coulter, Lachlan Coin
An outbreak of multi-drug resistant (MDR) tuberculosis (TB) has been reported on Daru Island, Papua New Guinea. Mycobacterium tuberculosis strains driving this outbreak and the temporal accrual of drug resistance mutations have not been described. Whole genome sequencing of 100 of 165 clinical isolates referred from Daru General Hospital to the Supranational reference laboratory, Brisbane, during 2012-2015 revealed that 95 belonged to a single modern Beijing sub-lineage strain. Molecular dating suggested acquisition of streptomycin and isoniazid resistance in the 1960s, with potentially enhanced virulence mediated by an mycP1 mutation...
January 4, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/29301898/complete-genome-sequences-of-two-multidrug-resistant-mycobacterium-tuberculosis-strains-isolated-in-guiyang-china
#9
Zhenghong Chen, Weizheng Ou, Xiangyu Fan, Guzhen Cui, Qiong Wang, Qiang Li, Rong Sun, Xiaojuan Wu, Wan Qin, Yan Wang
We identified the genome sequences of two Mycobacterium tuberculosis isolates. They were resistant to rifampin and isoniazid, as determined by the agar proportion method, but were susceptible to isoniazid, as determined by the DNA array method. The genome sequences showed that a katG deletion led to the false diagnosis of isoniazid resistance by DNA array.
January 4, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29299116/clinical-efficacy-of-short-course-chemotherapy-combined-with-topical-injection-therapy-in-treatment-of-superficial-lymph-node-tuberculosis
#10
Huiru An, Zhongyuan Wang, Hongbing Chen, Tao Wang, Xinjing Wang, Lin Liu, Xiao Liu, Jing Xu, Luxing He, Kai Zhang, Hongyan Zhang, Xinying Liu
To evaluate the clinical efficacy and safety of short-course chemotherapy combined with regional injection therapy in the treatment of superficial lymph node tuberculosis. 201 patients diagnosed with superficial lymph node tuberculosis were retrospectively analyzed. All patients were randomly divided into the study (n = 100) and control groups (n = 101). In the study group, the patients received 6-month chemotherapy with isoniazid (H), rifampin (R) and ethambutol (E) (6HRE) in combination with regional injection of streptomycin, and their counterparts in the control group underwent systemic regime of 3HRZE/6HRE...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298757/vitamin-c-potentiates-the-killing-of-mycobacterium-tuberculosis-by-the-first-line-tuberculosis-drugs-isoniazid-and-rifampicin-in-mice
#11
Catherine Vilchèze, John Kim, William R Jacobs
The treatment of drug-susceptible tuberculosis (TB) is long and cumbersome. Mismanagement of TB treatment can lead to the emergence of drug resistance in patients, so shortening the treatment duration could significantly improve TB chemotherapy and prevent the development of drug resistance. We had previously discovered that high concentrations of vitamin C sterilize cultures of drug-susceptible and drug-resistant Mycobacterium tuberculosis Here, we tested sub-inhibitory concentration of vitamin C in combination with TB drugs against M...
January 3, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29297443/screening-for-active-tuberculosis-before-isoniazid-preventive-therapy-among-hiv-infected-west-african-adults
#12
R Moh, A Badjé, J-B N'takpé, G M Kouamé, D Gabillard, T Ouassa, E Ouattara, J Le Carrou, F Bohoussou, E Messou, S Eholié, X Anglaret, C Danel
SETTING: TEMPRANO was a multicentre, open-label trial in which human immunodeficiency virus (HIV) infected adults with high CD4 counts were randomised into early or deferred antiretroviral therapy (ART) arms with or without 6-month isoniazid preventive therapy (IPT) in a setting where the World Health Organization (WHO) recommends IPT in HIV-infected patients. Despite the WHO recommendation, IPT coverage remains low due to fear of the presence of undiagnosed active TB before prescribing IPT, and the related risk of drug resistance...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297423/meropenem-clavulanate-for-drug-resistant-tuberculosis-a-follow-up-of-relapse-free-cases
#13
M C Payen, I Muylle, O Vandenberg, V Mathys, M Delforge, S Van den Wijngaert, N Clumeck, S De Wit
BACKGROUND: Extensively drug-resistant tuberculosis (XDR-TB), defined as TB caused by a Mycobacterium strain resistant to at least rifampicin, isoniazid, any fluoroquinolone and one of the injectable anti-tuberculosis drugs, remains a worldwide public health threat. Among repurposed drugs empirically used for XDR-TB cases, carbapenems have been studied in vitro and in animal models, with encouraging results. However, only short-term follow-up data from clinical studies are currently available...
January 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29290186/evaluation-of-nitrate-reductase-assay-for-early-detection-of-multi-and-extensively-drug-resistance-tuberculosis-in-our-setup
#14
Aamer Ikram Ikram, Muhammad Luqman Satti, Farida Khurram Lalani, Gohar Zaman, Adeel Hussain Gardezi, Parvez Ahmed
OBJECTIVE: To evaluate the performance of nitrate reductase assay on smear positive pulmonary specimens for detection of multi and extensively drug resistant tuberculosis simultaneously. STUDY DESIGN: Cross-sectional analytical study. PLACE AND DURATION OF STUDY: Microbiology Department, Armed Forces Institute of Pathology, Rawalpindi from June to December 2016. METHODOLOGY: Smear positive pulmonary samples were processed both by nitrate reductase method on Lowenstein Jenson medium and also inoculated on gold standard Bactec MGIT 960 TB system...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29288283/associations-between-mycobacterium-tuberculosis-beijing-genotype-and-drug-resistance-to-four-first-line-drugs-a-survey-in-china
#15
Haican Liu, Yuanyuan Zhang, Zhiguang Liu, Jinghua Liu, Yolande Hauck, Jiao Liu, Haiyan Dong, Jie Liu, Xiuqin Zhao, Bing Lu, Yi Jiang, Gilles Vergnaud, Christine Pourcel, Kanglin Wan
Investigations on the genetic diversity of Mycobacterium tuberculosis in China have shown that Beijing genotype strains play a dominant role. To study the association between the M. tuberculosis Beijing genotype and the drug-resistance phenotype, 1286 M. tuberculosis clinical isolates together with epidemiological and clinical information of patients were collected from the center for tuberculosis (TB) prevention and control or TB hospitals in Beijing municipality and nine provinces or autonomous regions in China...
December 29, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29284895/the-effects-of-aloe-vera-on-tnf-a-levels-the-percentage-of-nk-cells-and-th-17-cells-in-rat-that-received-izoniazid-and-rifampycin
#16
Herin Mawarti, Mukhamad Rajin, Zulfikar Asumta
Background: The present study was undertaken to investigate the hepatoprotective effect of Aloe vera against side effect of antituberculosis drug. Material and methods: Twenty-five rats will be divided into five groups, namely the control group (without any treatment), the group of rats treated with anti-tuberculosis drugs, and a group of rats were treated antituberculosis drugs and got Aloe vera extract at a dose of 40; 80; and 120 mg/kg body weight. Antituberculosis drugs are isoniazid and rifampicin a dose of 50 mg/kg body weight...
October 2017: Medical Archives
https://www.readbyqxmd.com/read/29284687/a-standardised-method-for-interpreting-the-association-between-mutations-and-phenotypic-drug-resistance-in-mycobacterium-tuberculosis
#17
Paolo Miotto, Belay Tessema, Elisa Tagliani, Leonid Chindelevitch, Angela M Starks, Claudia Emerson, Debra Hanna, Peter S Kim, Richard Liwski, Matteo Zignol, Christopher Gilpin, Stefan Niemann, Claudia M Denkinger, Joy Fleming, Robin M Warren, Derrick Crook, James Posey, Sebastien Gagneux, Sven Hoffner, Camilla Rodrigues, Iñaki Comas, David M Engelthaler, Megan Murray, David Alland, Leen Rigouts, Christoph Lange, Keertan Dheda, Rumina Hasan, Uma Devi K Ranganathan, Ruth McNerney, Matthew Ezewudo, Daniela M Cirillo, Marco Schito, Claudio U Köser, Timothy C Rodwell
A clear understanding of the genetic basis of antibiotic resistance in Mycobacterium tuberculosis is required to accelerate the development of rapid drug susceptibility testing methods based on genetic sequence.Raw genotype-phenotype correlation data were extracted as part of a comprehensive systematic review to develop a standardised analytical approach for interpreting resistance associated mutations for rifampicin, isoniazid, ofloxacin/levofloxacin, moxifloxacin, amikacin, kanamycin, capreomycin, streptomycin, ethionamide/prothionamide and pyrazinamide...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29282012/comparison-of-line-probe-assay-to-bactec-mgit-960-system-for-susceptibility-testing-of-first-and-second-line-anti-tuberculosis-drugs-in-a-referral-laboratory-in-south-africa
#18
Nontuthuko E Maningi, Lesibana A Malinga, John F Antiabong, Ruth M Lekalakala, Nontombi M Mbelle
BACKGROUND: The incidence of multidrug-resistant tuberculosis (MDR-TB) is increasing and the emergence of extensively drug-resistant tuberculosis (XDR-TB) is a major challenge. Controlling resistance, reducing transmission and improving treatment outcomes in MDR/XDR-TB patients is reliant on susceptibility testing. Susceptibility testing using phenotypic methods is labour intensive and time-consuming. Alternative methods, such as molecular assays are easier to perform and have a rapid turn-around time...
December 28, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29281707/inhibitory-activity-of-pentacyano-isoniazid-ferrate-ii-iqg-607-against-promastigotes-and-amastigotes-forms-of-leishmania-braziliensis
#19
Camila F Amorim, Luiza Galina, Natália B Carvalho, Nathalia D M Sperotto, Kenia Pissinate, Pablo Machado, Maria M Campos, Luiz A Basso, Valnês S Rodrigues-Junior, Edgar M Carvalho, Diógenes Santiago Santos
M. tuberculosis and parasites of the genus Leishmania present the type II fatty acid biosynthesis system (FASII). The pentacyano(isoniazid)ferrate(II) compound, named IQG-607, inhibits the enzyme 2-trans-enoyl-ACP(CoA) reductase from M. tuberculosis, a key component in the FASII system. Here, we aimed to evaluate the inhibitory activity of IQG-607 against promastigote and amastigote forms of Leishmania (Viannia) braziliensis isolated from patients with different clinical forms of L. braziliensis infection, including cutaneous, mucosal and disseminated leishmaniasis...
2017: PloS One
https://www.readbyqxmd.com/read/29281637/cell-envelope-stress-in-mycobacteria-is-regulated-by-the-novel-signal-transduction-atpase-inir-in-response-to-trehalose
#20
Maikel Boot, Vincent J C van Winden, Marion Sparrius, Robert van de Weerd, Alexander Speer, Roy Ummels, Tige Rustad, David R Sherman, Wilbert Bitter
The cell envelope of mycobacteria is a highly unique and complex structure that is functionally equivalent to that of Gram-negative bacteria to protect the bacterial cell. Defects in the integrity or assembly of this cell envelop must be sensed to allow the induction of stress response systems. The promoter that is specifically and most strongly induced upon exposure to ethambutol and isoniazid, first line drugs that affect cell envelope biogenesis, is the iniBAC promoter. In this study, we set out to identify the regulator of the iniBAC operon in Mycobacterium marinum using an unbiased transposon mutagenesis screen in a constitutively iniBAC-expressing mutant background...
December 27, 2017: PLoS Genetics
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