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https://www.readbyqxmd.com/read/29344085/synthesis-secretion-function-metabolism-and-application-of-natriuretic-peptides-in-heart-failure
#1
REVIEW
Shihui Fu, Ping Ping, Fengqi Wang, Leiming Luo
As a family of hormones with pleiotropic effects, natriuretic peptide (NP) system includes atrial NP (ANP), B-type NP (BNP), C-type NP (CNP), dendroaspis NP and urodilatin, with NP receptor-A (guanylate cyclase-A), NP receptor-B (guanylate cyclase-B) and NP receptor-C (clearance receptor). These peptides are genetically distinct, but structurally and functionally related for regulating circulatory homeostasis in vertebrates. In humans, ANP and BNP are encoded by NP precursor A (NPPA) and NPPB genes on chromosome 1, whereas CNP is encoded by NPPC on chromosome 2...
2018: Journal of Biological Engineering
https://www.readbyqxmd.com/read/29342111/cytotoxicity-evaluation-of-turmeric-extract-incorporated-oil-in-water-nanoemulsion
#2
Hee Jeong Yoon, Xiaowei Zhang, Min Gyeong Kang, Gyeong Jin Kim, Sun Young Shin, Sang Hong Baek, Bom Nae Lee, Su Jung Hong, Jun Tae Kim, Kwonho Hong, Hojae Bae
To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving the delivery of active ingredients. However, safety evaluation is crucial during the development stage before the commercialization. Therefore, the aim of this study was to evaluate the cytotoxicity of two types of newly developed nanoemulsions. Turmeric extract-loaded nanoemulsion powder-10.6 (TE-NEP-10.6, high content of artificial surfactant Tween 80), which forms the optimal nanoemulsion, and the TE-NEP-8...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29339171/dna-methylation-level-of-the-neprilysin-promoter-in-alzheimer-s-disease-brains
#3
Kenichi Nagata, Tatsuo Mano, Shigeo Murayama, Takaomi C Saido, Atsushi Iwata
Neprilysin (NEP), a membrane-bound metalloprotease, has been shown to play an essential role in the clearance of amyloid beta (Aβ) peptides. Previous studies have reported that NEP expression is downregulated in the normal aging brain as well as in the Alzheimer's disease (AD) brain, providing evidence that the downregulation of NEP expression contributes to the age-dependent deposition of Aβ-containing plaques, a pathological hallmark of AD. However, the mechanisms underlying the downregulation remain unclear...
January 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29330702/ptac10-an-s1-domain-containing-component-of-the-transcriptionally-active-chromosome-complex-is-essential-for-plastid-gene-expression-in-arabidopsis-thaliana-and-is-phosphorylated-by-chloroplast-targeted-casein-kinase-ii
#4
Qing-Bo Yu, Tuan-Tuan Zhao, Lin-Shan Ye, Ling Cheng, Ying-Qian Wu, Chao Huang, Zhong-Nan Yang
In higher plant chloroplasts, the plastid-encoded RNA polymerase (PEP) consists of four catalytic subunits and numerous nuclear-encoded accessory proteins, including pTAC10, an S1-domain-containing protein. In this study, pTAC10 knockout lines were characterized. Two ptac10 mutants had an albino phenotype and severely impaired chloroplast development. The pTAC10 genomic sequence fused to a four-tandem MYC tag driven by its own promoter functionally complemented the ptac10-1 mutant phenotype. pTAC10 was present in both the chloroplast stroma and thylakoids...
January 12, 2018: Photosynthesis Research
https://www.readbyqxmd.com/read/29330223/the-anti-oxidant-xanthorrhizol-prevents-amyloid-%C3%AE-induced-oxidative-modification-and-inactivation-of-neprilysin
#5
Chol Seung Lim, Jung-Soo Han
Activity of neprilysin (NEP), the major protease which cleaves β-amyloid (Aβ), is reportedly reduced in the brains of patients with Alzheimer's disease (AD). Accumulation of Aβ generates reactive oxygen species (ROS) such as 4-hydroxy nonenal (HNE), and then reduces activities of Aβ-degrading enzymes including NEP. Xanthorrhizol (Xan), a natural sesquiterpenoid, has been reported to possess anti-oxidant and anti-inflammatory properties. The present study examined the effects of Xan on HNE- or oligomeric Aβ42-induced oxidative modification of NEP protein...
January 12, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29328932/effective-algal-harvesting-by-using-mesh-membrane-for-enhanced-energy-recovery-in-an-innovative-integrated-photobioelectrochemical-system
#6
Shuai Luo, Pranav Sai Shankar Sampara, Zhen He
In this work, an innovative design of integrated photobioelectrochemcial system (IPB) and an algal harvesting method based on polyester-mesh membrane (MM) were investigated. The algal growth/harvesting period of 6 days led to the highest surface biomass productivity (SBP) of 0.88 g m-2 day-1 and the highest energy generation of 0.157 ± 0.001 kJ day-1. The harvesting frequency of 3 times in an operational cycle (with three pieces of MM) enhanced the SBP to 1.14 g m-2 day-1. The catholyte recirculation for catholyte mixing resulted in a positive net energy production (NEP) of 0...
January 3, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29323711/hiv-1-increases-extracellular-amyloid-beta-levels-through-neprilysin-regulation-in-primary-cultures-of-human-astrocytes
#7
Marta Martínez-Bonet, M Ángeles Muñoz-Fernández, Susana Álvarez
Since the success of combined antiretroviral therapy, HIV-1-infected individuals are now living much longer. This increased life expectancy is accompanied by a higher prevalence of HIV-1 associated neurocognitive disorders. Rising too is the incidence in these patients of pathological hallmarks of Alzheimer's disease such as increased deposition of amyloid beta protein (Aβ). Although neurons are major sources of Aβ in the brain, astrocytes are the most numerous glial cells, therefore, even a small level of astrocytic Aβ metabolism could make a significant contribution to brain pathology...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29319227/fructokinase-like-protein-1-interacts-with-trxz-to-regulate-chloroplast-development-in-rice
#8
Lei He, Sen Zhang, Zhennan Qiu, Juan Zhao, Wendan Nie, Haiyan Lin, Zhengge Zhu, Dali Zeng, Qian Qian, Li Zhu
Chloroplast genes are transcribed by the PEP or NEP. FRUCTOKINASE-LIKE PROTEINS (FLNs) are phosphofructokinase-B (PfkB)-type carbohydrate kinases that act as part of the PEP complex; however, the molecular mechanisms underlying FLNs activity in rice remain elusive. Previously, we identified and characterized a heat-stress sensitive albino (hsa1) mutant in rice. Map-based cloning revealed that HSA1 encodes a putative OsFLN2. Here, we further demonstrated that knockdown or knockout of the OsFLN1, a close homolog of HSA1/OsFLN2, considerably inhibits chloroplast biogenesis and the fln1 knockout mutants created by CRISPR/Cas9 exhibit severe albino phenotype and seedling lethality...
January 10, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29302313/the-national-evaluation-platform-for-maternal-newborn-and-child-health-and-nutrition-from-idea-to-implementation
#9
REVIEW
Rebecca Heidkamp
No abstract text is available yet for this article.
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29279555/pharmacotherapy-for-neuropathic-pain-in-japan
#10
Ritsuko Masuda, Junko Ajimi, Tomohiko Murata
Neuropathic pain (NeP) results from injury to, or disease of, the peripheral or central components of the neural systems involved in pain. In contrast to inflammatory pain, NeP can persist after healing from the initial injury has resolved. Antipyretic agents, such as non-steroidal anti-inflammatory drugs, steroids, and acetaminophen are ineffective, while specific agents such as gabapentinoids, antidepressants, antiepileptics, and opioids are effective in treating NeP. In this review, we address the definition of NeP, pharmacotherapy for NeP in Japan, pain classification, setting goals for successful NeP medication, and the Japanese algorithm for the pharmacotherapy of NeP with specific prescription guidance...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29232715/profound-loss-of-neprilysin-accompanied-by-decreased-levels-of-neuropeptides-and-increased-crp-in-ulcerative-colitis
#11
Zeynep Gök Sargın, Nuray Erin, Gokhan Tazegul, Gülsüm Özlem Elpek, Bülent Yıldırım
Neprilysin (NEP, CD10) acts to limit excessive inflammation partly by hydrolyzing neuropeptides. Although deletion of NEP exacerbates intestinal inflammation in animal models, its role in ulcerative colitis (UC) is not well explored. Herein, we aimed to demonstrate changes in NEP and associated neuropeptides at the same time in colonic tissue. 72 patients with UC and 27 control patients were included. Patients' demographic data and laboratory findings, five biopsy samples from active colitis sites and five samples from uninvolved mucosa were collected...
2017: PloS One
https://www.readbyqxmd.com/read/29225253/an-analysis-of-the-neuropathic-pain-components-in-rheumatoid-arthritis-patients
#12
Satoshi Ito, Daisuke Kobayashi, Akira Murasawa, Ichiei Narita, Kiyoshi Nakazono
Objective To analyze the neuropathic pain (NeP) components in patients with rheumatoid arthritis (RA). Patients and Methods The pain DETECT questionnaire (PD-Q) was completed by 300 RA patients (79 men, 221 women). Results Nine patients (3.0%) were categorized as likely NeP, 33 (11.0%) were categorized as possible NeP, and 258 (86.0%) were categorized as unlikely NeP. When we excluded patients with diabetes mellitus, spinal diseases, neurological diseases, and herpes zoster infection (conditions associated with NeP), 5 of the patients (1...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29218539/carbon-storage-potential-increases-with-increasing-ratio-of-c4-to-c3-grass-cover-and-soil-productivity-in-restored-tallgrass-prairies
#13
Brian J Spiesman, Herika Kummel, Randall D Jackson
Long-term soil carbon (C) storage is essential for reducing CO2 in the atmosphere. Converting unproductive and environmentally sensitive agricultural lands to grasslands for bioenergy production may enhance C storage. However, a better understanding of the interacting effects of grass functional composition (i.e., relative abundance of C4 and C3 grass cover) and soil productivity on C storage will help guide sustainable grassland management. Our objective was to examine the relationship between grass functional composition and potential C storage and how it varies with potential soil productivity...
December 7, 2017: Oecologia
https://www.readbyqxmd.com/read/29198549/development-and-validation-of-a-taiwan-version-of-the-id-pain-questionnaire-id-pain-t
#14
Chih-Chao Yang, Long-Sun Ro, Yu-Chuan Tsai, Kon-Ping Lin, Wei-Zen Sun, Wei-Tse Fang, Shuu-Jiun Wang
BACKGROUND: Neuropathic pain (NeP) is distinct from nociceptive pain and has different underlying mechanisms requiring specific treatment strategies. To aid diagnosis, self-administered screening questionnaires (such as ID Pain) have been developed to help physicians identify patients with NeP. The aim of this study was to develop and validate a translated ID Pain questionnaire for Taiwanese subjects (ID Pain-T). METHODS: ID Pain, a 6-item self-administered questionnaire, score ranged from -1 to 5, was translated from English into Mandarin Chinese using local terms and back-translated by an expert panel...
November 30, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29191928/sustained-activation-of-rho-gtpases-promotes-a-synthetic-pulmonary-artery-smooth-muscle-cell-phenotype-in-neprilysin-null-mice
#15
Vijaya Karoor, Mehdi A Fini, Zoe Loomis, Timothy Sullivan, Louis B Hersh, Evgenia Gerasimovskaya, David Irwin, Edward C Dempsey
OBJECTIVE: Pulmonary artery smooth muscle cells (PASMCs) from neprilysin (NEP) null mice exhibit a synthetic phenotype and increased activation of Rho GTPases compared with their wild-type counterparts. Although Rho GTPases are known to promote a contractile SMC phenotype, we hypothesize that their sustained activity decreases SM-protein expression in these cells. APPROACH AND RESULTS: PASMCs isolated from wild-type and NEP-/- mice were used to assess levels of SM-proteins (SM-actin, SM-myosin, SM22, and calponin) by Western blotting, and were lower in NEP-/- PASMCs compared with wild-type...
November 30, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29190943/neuroprotective-effects-of-bajijiasu-against-cognitive-impairment-induced-by-amyloid-%C3%AE-in-app-ps1-mice
#16
Haobin Cai, Yijie Wang, Jiayang He, Tiantian Cai, Jun Wu, Jiansong Fang, Rong Zhang, Zhouke Guo, Li Guan, Qinkai Zhan, Li Lin, Yao Xiao, Huafeng Pan, Qi Wang
Alzheimer's disease (AD) is a progressive neurological degenerative disease. The main clinical manifestations of AD include progressive cognitive impairment and alteration of personality. Senile plaques, neuroinflammation, and destruction of synapse structure stability are the main pathological features of AD. Bajijiasu(BJJS) is extracted from Morinda Officinalis, a Chinese herb. In this study, we explored the effect of BJJS on AD from many aspects in APPswe/PSEN1ΔE9 (APP/PS1) double transgenic mice. The Morris water maze and novel object recognition tests results showed that BJJS could significantly improve the learning and memory abilities in APP/PS1 mice...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29187381/crrl269-a-novel-designer-and-renal-enhancing-pgc-a-peptide-activator
#17
Yang Chen, Gail J Harty, Brenda K Huntley, Seethalakshmi R Iyer, Denise M Heublein, Gerald E Harders, Laura M G Meems, Shuchong Pan, S Jeson Sangaralingham, Tomoko Ichiki, John C Burnett
AIMS: The natriuretic peptides (NPs) b-type NP (BNP) and urodilatin (URO) exert renal protective properties via the particulate guanylyl cyclase A receptor (pGC-A). As a potential renal enhancing strategy, we engineered a novel designer peptide that we call CRRL269. CRRL269 was investigated in human cell lines and in normal canines to define potential cardiorenal enhancing actions. The mechanism of its cardiorenal selective properties was also investigated. METHODS AND RESULTS: In vitro NP receptor activity was quantified with 3', 5' cyclic guanosine monophosphate (cGMP) generation...
November 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29162817/surface-plasmon-induced-direct-detection-of-long-wavelength-photons
#18
Jinchao Tong, Wei Zhou, Yue Qu, Zhengji Xu, Zhiming Huang, Dao Hua Zhang
Millimeter and terahertz wave photodetectors have long been of great interest due to a wide range of applications, but they still face challenges in detection performance. Here, we propose a new strategy for the direct detection of millimeter and terahertz wave photons based on localized surface-plasmon-polariton (SPP)-induced non-equilibrium electrons in antenna-assisted subwavelength ohmic metal-semiconductor-metal (OMSM) structures. The subwavelength OMSM structure is used to convert the absorbed photons into localized SPPs, which then induce non-equilibrium electrons in the structure, while the antenna increases the number of photons coupled into the OMSM structure...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29154891/acute-pain-perception-during-different-sampling-methods-for-respiratory-culture-in-cystic-fibrosis-patients
#19
Hanneke Eyns, Elke De Wachter, Anne Malfroot, Peter Vaes
BACKGROUND: Reliable identification of lower respiratory tract pathogens is crucial in the management of cystic fibrosis (CF). As part of another study (NCT02363764) investigating the bacterial yield of three sampling methods: nasal swabs (NS), cough swabs (CS) and (induced) sputum samples ((I)SS) in both expectorating (EPs) and non-expectorating (NEPs) patients with CF, the present study aimed to explore the prevalence of respiratory culture sampling-related pain as assessed by self-report within a cohort of children and adults...
November 14, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29143682/using-the-lives-saved-tool-to-aid-country-planning-in-meeting-mortality-targets-a-case-study-from-mali
#20
Youssouf Keita, Hamadoun Sangho, Timothy Roberton, Emilia Vignola, Mariam Traoré, Melinda Munos
BACKGROUND: Mali is one of four countries implementing a National Evaluation Platform (NEP) to build local capacity to answer evaluation questions for maternal, newborn, child health and nutrition (MNCH&N). In 2014-15, NEP-Mali addressed questions about the potential impact of Mali's MNCH&N plans and strategies, and identified priority interventions to achieve targeted mortality reductions. METHODS: The NEP-Mali team modeled the potential impact of three intervention packages in the Lives Saved Tool (LiST) from 2014 to 2023...
November 7, 2017: BMC Public Health
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