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https://www.readbyqxmd.com/read/29774745/interplay-between-copper-neprilysin-and-n-truncation-of-%C3%AE-amyloid
#1
Mariusz Mital, Wojciech Bal, Tomasz Frączyk, Simon C Drew
Sporadic Alzheimer's disease (AD) is associated with an inefficient clearance of the β-amyloid (Aβ) peptide from the central nervous system. The protein levels and activity of the Zn2+ -dependent endopeptidase neprilysin (NEP) inversely correlate with brain Aβ levels during aging and in AD. The present study considered the ability of Cu2+ ions to inhibit human recombinant NEP and the role for NEP in generating N-truncated Aβ fragments with high-affinity Cu2+ binding motifs that can prevent this inhibition...
May 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29771464/degradation-of-amyloid-%C3%AE-peptide-by-neprilysin-expressed-from-borna-disease-virus-vector
#2
Madoka Sakai, Sakiho Ueda, Takuji Daito, Megumi Asada-Utsugi, Yumiko Komatsu, Ayae Kinoshita, Takakuni Maki, Akira Kuzuya, Ryosuke Takahashi, Akiko Makino, Keizo Tomonaga
Accumulation of amyloid β (Aβ40 and Aβ42) in the brain is a characteristic of Alzheimer's disease (AD). Because neprilysin (NEP) is a major Aβ-degrading enzyme, NEP delivery in the brain is a promising gene therapy for AD. Borna disease virus (BoDV) vector enables long-term transduction of foreign genes in the central nerve system. Here, we evaluated the proteolytic ability of NEP transduced by the BoDV vector and found that the amounts of Aβ40 and Aβ42 significantly decreased, which suggests that NEP expressed from the BoDV vector is functional to degrade Aβ...
May 17, 2018: Microbiology and Immunology
https://www.readbyqxmd.com/read/29768653/n-ethyl-pentylone-related-deaths-in-alabama
#3
Daniel Atherton, Daniel Dye, C Andrew Robinson, Rachel Beck
n-Ethyl pentylone (NEP) is a chemical substance derived from cathinone. Synthetic cathinones are an evolving group of drugs with stimulating, mind-altering effects sometimes referred to as novel or new psychoactive substances (NPS). There is scarce information in the medical literature regarding forensic cases in which NEP is detected in toxicological testing. We present four fatalities involving NEP from Alabama in 2017. Deaths were attributed to NEP toxicity in two cases (peripheral blood concentrations of 0...
May 16, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29767850/forest-aging-disturbance-and-the-carbon-cycle
#4
REVIEW
Peter S Curtis, Christopher M Gough
Contents Summary I. Introduction II. Forest aging and carbon storage III. Successional trends of NEP in northern deciduous forests IV. Mechanisms sustaining NEP in aging deciduous forests Acknowledgements References SUMMARY: Large areas of forestland in temperate North America, as well as in other parts of the world, are growing older and will soon transition into middle and then late successional stages exceeding 100 yr in age. These ecosystems have been important regional carbon sinks as they recovered from prior anthropogenic and natural disturbance, but their future sink strength, or annual rate of carbon storage, is in question...
May 16, 2018: New Phytologist
https://www.readbyqxmd.com/read/29766796/biological-and-in-silico-studies-on-synthetic-analogues-of-tyrosine-betaine-as-inhibitors-of-neprilysin-a-drug-target-for-the-treatment-of-heart-failure
#5
Daniel Fabio Kawano, Marcelo Rodrigues de Carvalho, Mauricio Ferreira Marcondes Machado, Adriana Karaoglanovic Carmona, Gilberto Ubida Leite Braga, Ivone Carvalho
BACKGROUND: Fungal secondary metabolites are important sources for the discovery of new pharmaceuticals, as exemplified by penicillin, lovastatin and cyclosporine. Searching for secondary metabolites of the fungi Metarhizium ssp., we previously identified tyrosine betaine as a major constituent. METHODS: Because of the structural similarity with other inhibitors of neprilysin (NEP), an enzyme explored for the treatment of heart failure, we devised the synthesis of tyrosine betaine and three analogues to be subjected to in vitro NEP inhibition assays and to molecular modeling studies...
May 14, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29765677/drivers-of-temporal-beta-diversity-of-a-benthic-community-in-a-seasonally-hypoxic-fjord
#6
Jackson W F Chu, Curtis Curkan, Verena Tunnicliffe
Global expansion of oxygen-deficient (hypoxic) waters will have detrimental effects on marine life in the Northeast Pacific Ocean (NEP) where some of the largest proportional losses in aerobic habitat are predicted to occur. However, few in situ studies have accounted for the high environmental variability in this region while including natural community-assembly dynamics. Here, we present results from a 14-month deployment of a benthic camera platform tethered to the VENUS cabled observatory in the seasonally hypoxic Saanich Inlet...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29759823/self-rated-health-and-wellbeing-among-school-aged-children-with-and-without-special-educational-needs-differences-between-mainstream-and-special-schools
#7
Katharina Rathmann, Theres Vockert, Ludwig Bilz, Markus Gebhardt, Klaus Hurrelmann
BACKGROUND: Studies among students with special educational needs (SEN) in separate special schools (SSS) and mainstream schools (MS) are particularly applicable to educational attainment and social participation. However, indicators of health and wellbeing have rarely been considered. AIMS: This study investigates two related topics: first, health and wellbeing differences between students with SEN in special schools (SSS) and students without SEN in regular schools, and second, the rarely considered question whether health and wellbeing among students with SEN differ between school settings (i...
May 11, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29752565/alanine-scan-of-sialorphin-and-its-hybrids-with-opiorphin-synthesis-molecular-modelling-and-effect-on-enkephalins-degradation
#8
Małgorzata Sobocińska, Artur Giełdoń, Jakub Fichna, Elżbieta Kamysz
Enkephalins are involved in a number of physiological processes. However, these peptides are quickly degraded by peptidases, e.g. the neutral endopeptidase (NEP). Inhibition of the enzymatic degradation of enkephalins is one of the possible approaches to prolong their activity. Selective inhibitor of NEP, sialorphin, is the attractive lead compound for enkephalins degradation studies. In this work, an alanine scan of sialorphin and a series of its hybrids with opiorphin, synthesised by the solid phase method, were performed...
May 12, 2018: Amino Acids
https://www.readbyqxmd.com/read/29744650/a-novel-in-vivo-porcine-model-of-intervertebral-disc-degeneration-induced-by-cryoinjury
#9
Charles-Henri Flouzat-Lachaniette, Nicolas Jullien, Charlie Bouthors, Eric Beohou, Béatrice Laurent, Philippe Bierling, Arnaud Dubory, Hélène Rouard
PURPOSE: Degenerative disc disease involves sequential events that lead to the loss of cells, a decrease in disc matrix production, disc dehydration, and alteration of its biomechanical properties. The aim of this study was to determine whether cryoinjury of the nucleus pulposus performed through endplate perforation contributes to disc degeneration and to compare this technique with standard methods. METHOD: Under general anesthesia, the lumbar discs of six pigs were exposed and randomly submitted to needle puncture of the annulus fibrosus (NeP), isolated endplate injury (EP), or cryoinjury using a 2...
May 10, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29736982/climatic-role-of-terrestrial-ecosystem-under-elevated-co-2-a-bottom-up-greenhouse-gases-budget
#10
REVIEW
Shuwei Liu, Cheng Ji, Cong Wang, Jie Chen, Yaguo Jin, Ziheng Zou, Shuqing Li, Shuli Niu, Jianwen Zou
The net balance of greenhouse gas (GHG) exchanges between terrestrial ecosystems and the atmosphere under elevated atmospheric carbon dioxide (CO2 ) remains poorly understood. Here, we synthesise 1655 measurements from 169 published studies to assess GHGs budget of terrestrial ecosystems under elevated CO2 . We show that elevated CO2 significantly stimulates plant C pool (NPP) by 20%, soil CO2 fluxes by 24%, and methane (CH4 ) fluxes by 34% from rice paddies and by 12% from natural wetlands, while it slightly decreases CH4 uptake of upland soils by 3...
May 7, 2018: Ecology Letters
https://www.readbyqxmd.com/read/29713968/association-of-neuropathic-like-pain-characteristics-with-clinical-and-radiographic-features-in-patients-with-ankylosing-spondylitis
#11
Jung-Hye Choi, Sang-Heon Lee, Hae-Rim Kim, Kyung-Ann Lee
Ankylosing spondylitis (AS) is a chronic, progressive, and inflammatory disorder and causes chronic back pain. It is not unusual for patients with AS to have symptoms similar to neuropathic pain. We aimed to investigate the neuropathic pain (NeP) component in patients with AS using the painDETECT questionnaire (PD-Q) and to assess the relation between NeP and the disease characteristics of AS. A single-center prospective study was performed, including 105 patients. Patients with AS completed three questionnaires: PD-Q, Beck Depression Inventory (BDI), and Euro Quality of Life (EQ-5D) questionnaires...
April 30, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29710567/net-ecosystem-productivity-and-carbon-dynamics-of-the-traditionally-managed-imperata-grasslands-of-north-east-india
#12
Karabi Pathak, Yadvinder Malhi, G W Sileshi, Ashesh Kumar Das, Arun Jyoti Nath
There have been few comprehensive descriptions of how fire management and harvesting affect the carbon dynamics of grasslands. Grasslands dominated by the invasive weed Imperata cylindrica are considered as environmental threats causing low land productivity throughout the moist tropical regions in Asia. Imperata grasslands in North East India are unique in that they are traditionally managed and culturally important in the rural landscapes. Given the importance of fire in the management of Imperata grassland, we aimed to assess (i) the seasonal pattern of biomass production, (ii) the eventual pathways for the produced biomass, partitioned between in situ decomposition, harvesting and combustion, and (iii) the effect of customary fire management on the ecosystem carbon cycle...
April 21, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29708517/neuropathic-pain-component-in-axial-spondyloarthritis-and-the-influence-on-disease-burden
#13
Kevser Gok, Gizem Cengiz, Kemal Erol, Salih Ozgocmen
OBJECTIVES: Patients with nonradiographic axial spondyloarthritis (nr-axSpA) and radiographic axSpA/ankylosing spondylitis (AS) have similar burden of disease; however, the potential influence of pain characteristics including the neuropathic pain (NeP) component has not been assessed yet. The aim of this study was first to assess frequency of NeP component in patients with axSpA and second to assess the potential influence of NeP on burden of disease. METHODS: Adult patients who met the Assessment of SpondyloArthritis International Society classification criteria for axSpA were consecutively recruited...
February 22, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29702204/chronic-intermittent-hypoxia-induces-changes-on-the-expression-and-activity-of-neprilysin-ec-3-4-24-16-in-the-brain-of-rats
#14
Renato W de Oliveira, Guilherme S Julian, Juliana C Perry, Sergio Tufik, Jair R Chagas
Obstructive sleep apnea (OSA) is a frequent sleeping breathing disorder associated with cognitive impairments. Neprilysin (NEP) is responsible for degrading several substrates related to cognition; however, the effect of chronic intermittent hypoxia (CIH) on NEP is still unknown. This study aimed to evaluate the expression and activity of NEP under CIH in cognitive-related brain structures. Western blot, qRT-PCR and enzyme activity assay, demonstrated that a six-week intermittent hypoxia increased NEP expression and activity, selectively in temporal cortex, but not in the hippocampus and frontal cortex...
April 24, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29690949/energy-utilisation-of-broiler-chickens-in-response-to-guanidinoacetic-acid-supplementation-in-diets-with-various-energy-contents
#15
Sayed Sadra Ale Saheb Fosoul, Arash Azarfar, Abbasali Gheisari, Heshmatollah Khosravinia
This experiment was conducted to investigate the effects of guanidinoacetic acid (GAA) on productive performance, intestinal morphometric features, blood parameters and energy utilisation in broiler chickens. A total of 390 male broiler chicks (Ross 308) were assigned to six dietary treatments based on a factorial arrangement (2×3) across 1-15 and 15-35-d periods. Experimental treatments consisted of two basal diets with standard (STD; starter: 12·56 MJ/kg and grower: 12·97 MJ/kg) and reduction (LME; starter: 11·93 MJ/kg and grower: 12·33 MJ/kg) of apparent metabolisable energy (AME) requirement of broiler chickens each supplemented with 0, 0·6 and 1·2 g/kg GAA...
April 25, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29674956/mir-103-promotes-neurite-outgrowth-and-suppresses-cells-apoptosis-by-targeting-prostaglandin-endoperoxide-synthase-2-in-cellular-models-of-alzheimer-s-disease
#16
Hui Yang, Hongcai Wang, Yongwei Shu, Xuling Li
miR-103 has been reported to be decreased in brain of transgenic mouse model of Alzheimer's disease (AD) and in cerebrospinal fluid (CSF) of AD patients, while the detailed mechanism of its effect on AD is obscure, thus this study aimed to investigate the effect of miR-103 expression on neurite outgrowth and cells apoptosis as well as its targets in cellular models of AD. Blank mimic (NC1-mimic), miR-103 mimic, blank inhibitor (NC2-mimic) and miR-103 inhibitor plasmids were transferred into PC12 cellular AD model and Cellular AD model of cerebral cortex neurons which were established by Aβ1-42 insult...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29664606/radiometal-dependent-biological-profile-of-the-radiolabeled-grpr-antagonist-sb3-in-cancer-theranostics-metabolic-and-biodistribution-patterns-defined-by-neprilysin
#17
Emmanouil Lymperis, Aikaterini Kaloudi, Werner Sallegger, Ingrid L Bakker, Eric P Krenning, Marion DeJong, Theodosia Maina, Berthold Artur Nock
Recent advances in oncology involve the use of diagnostic/therapeutic radionuclide-carrier pairs that target cancer cells, offering exciting opportunities for personalized patient treatment. Theranostic gastrin-releasing peptide receptor (GRPR)-directed radiopeptides have been proposed for the management of GRPR-expressing prostate and breast cancers. We have recently introduced the PET tracer 68Ga-SB3 (SB3, DOTA-p-aminomethylaniline-diglycolic acid-DPhe-Gln-Trp-Ala-Val-Gly-His-Leu-NHEt), a receptor-radioantagonist that enables the visualization of GRPR-positive lesions in human...
April 17, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29561897/the-spine-paindetect-questionnaire-development-and-validation-of-a-screening-tool-for-neuropathic-pain-caused-by-spinal-disorders
#18
Takuya Nikaido, Masahiko Sumitani, Miho Sekiguchi, Shinichi Konno
OBJECTIVES: To develop screening tools for neuropathic pain caused by spinal disorders, the Spine painDETECT questionnaire (SPDQ) and its short-form version (SF-SPDQ), by modifying the Japanese version of the painDETECT questionnaire (PDQ-J), and to validate these tools. METHODS: Using data from patients with neuropathic pain caused by spinal disorders (NeP-SD) and patients with nociceptive pain caused by joint disorders (NocP) as controls, we devised a scoring system for the SPDQ by calculating weighting coefficients for nine PDQ-J items...
2018: PloS One
https://www.readbyqxmd.com/read/29561187/increased-urinary-angiotensin-converting-enzyme-2-ace2-and-neprilysin-nep-in-type-2-diabetic-patients
#19
Sridevi Gutta, Nadja Grobe, Meenasri Kumbaji, Hassan Osman, Mohammad Saklayen, Gengxin Li, Khalid M Elased
ACE2 and NEP are metalloproteases which are highly expressed in the renal proximal tubules. ACE2 and NEP generate renoprotective angiotensin (1-7) from angiotensin II (Ang II) and Ang I, respectively, and therefore could have a major role in chronic kidney disease (CKD). Recent data demonstrated increased urinary ACE2 in diabetic patients with CKD and kidney transplants. We tested the hypothesis that urinary ACE2, NEP and ADAM17 are increased and could be risk predictors of CKD in diabetic patients. Urinary and plasma ACE2, NEP, and ADAM17 were investigated in twenty healthy nondiabetics (ND), and forty diabetic patients with normoalbuminuria (Dnormo), microalbuminuria (Dmicro) and macroalbuminuria (Dmacro) using ELISA, Western blot, fluorogenic and novel mass spectrometric-based enzyme assays...
March 21, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29556947/in-vivo-stabilized-sb3-an-attractive-grpr-antagonist-for-pre-and-intra-operative-imaging-for-prostate-cancer
#20
Ingrid L Bakker, Sandra T van Tiel, Joost Haeck, Gabriela N Doeswijk, Erik de Blois, Marcel Segbers, Theodosia Maina, Berthold A Nock, Marion de Jong, Simone U Dalm
PURPOSE: The gastrin-releasing peptide receptor (GRPR), overexpressed on various tumor types, is an attractive target for receptor-mediated imaging and therapy. Another interesting approach would be the use of GRPR radioligands for pre-operative imaging and subsequent radio-guided surgery, with the goal to improve surgical outcome. GRPR radioligands were successfully implemented in clinical studies, especially Sarabesin 3 (SB3) is an appealing GRPR antagonist with high receptor affinity...
March 19, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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